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b/data/s2orc_abstract/2-5/731_732.jsonl @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:98c7f91871654cb537e997ce9da8684fb71c7e8b0fd2caeb364d70c40beb5e62 +size 15918404 diff --git a/data/s2orc_abstract/2-5/732_732.jsonl b/data/s2orc_abstract/2-5/732_732.jsonl new file mode 100644 index 0000000000000000000000000000000000000000..0fb7311ce081c4f2a33a2c9ce6b4f78dcc88888a --- /dev/null +++ b/data/s2orc_abstract/2-5/732_732.jsonl @@ -0,0 +1,4158 @@ +{"text":"With the advancement of technology, demand for Computer Numerical Control (CNC) plotter machines in Educational Institutions and Laboratories is rapidly rising. Low cost manufacture of Printed Circuit Board (PCB) has become a basic need in electronics laboratories, for electronics engineering students and for electronics hobbyists. This paper will present an affordable model of a CNC plotter machine which is able to draw a circuit layout on PCB or any other solid surface using simple algorithm and available components. At first the user needs to convert any image file or text file into G code using Inkspace software and then feed it to the machine using Processing software. Arduino uno with an ATmega328P microcontroller is used as the control device for this project. The microcontroller converts G-code into a set of machine language instruction to be sent to the motor driver of the CNC plotter.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27118899,"openaccessinfo":{"externalids":{"MAG":"2602681698","ACL":null,"DOI":"10.14445\/22315381\/IJETT-V43P256","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Global Earth Overshoot Day, the date when all annually available natural resources are consumed, is set for July this year. For densely populated European countries like Germany or Switzerland, that specific day is due even earlier (May). To overcome such an unsustainable lifestyle, immediate actions are required, which includes substantial educational efforts. As the model of \"Sustainable Development\" is complex, appropriate pedagogical actions need to support cognitive learning, critical thinking and behavioural actions. Knowledge about individual conceptions in relation to the Environment, Nature and Ecological Footprints contributes to pre-conditions to succeed. To what extent present teaching methods influenced individual conceptions during the first UN-decade regarding those terms is illustrated by 464 Swiss-German university freshmen who participated in our paper-pencil test, which is based on four open questions. The term of Environment was perceived as the sum of biocentric, ecocentric and anthropocentric views. The participants often equated the term to Nature and associated it with positive feelings or emotions. Therefore, calm, joy and aesthetic appreciation were predominantly named. Regardless of the concept, humans were perceived as the Greatest Environmental Threat. In contrast, recommendations to reduce Environmental Footprints regarding mobility & transport, waste avoidance and consumption differ. Following a binary logistic regression analysis, the involvement of the Inclusion of Self Scale (INS) was used as an explanatory variable to detect patterns of those conceptions. Relating sustainable concepts, natural resources were frequently named exceeding saving water and energy or other association dealt with second-hand issues or regional\/ seasonal usages. Such ideas are shaped by experiences and scientific expertise.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219701662,"openaccessinfo":{"externalids":{"MAG":"3034427229","ACL":null,"DOI":"10.1371\/journal.pone.0234560","PubMedCentral":"7295217","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0234560&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The Five Hundred Year Initiative stresses the value of cross-disciplinary perspectives in investigating the antecedents of contemporary southern African societies, with archaeological sources playing a prominent role in its associated projects. To produce effective histories, these projects require analytical attention to both the processes that gave rise to contemporary societies and those that shape history making in the present. In this article, I build on Paul Gilroy's notion of 'route work' (by comparison to 'root work') to explore the value and methodological challenges of constructing historical understandings that simultaneously attend to the dynamics of past cultural practice and the processes through which our understandings of those practices are produced. Drawing on examples from Ghana, I argue that a methodological engagement with the negotiated quality of historical understanding \u2013 an approach that brings into view our processes of 'coming to know' \u2013 lays the groundwork for an ethic...","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145291349,"openaccessinfo":{"externalids":{"MAG":"2089988178","ACL":null,"DOI":"10.1080\/02582473.2010.493001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The interaction between light and matter during laser machining is particularly challenging to model via analytical approaches. Here, we show the application of a statistical approach that constructs a model of the machining process directly from experimental images of the laser machined sample, and hence negating the need for understanding the underlying physical processes. Specifically, we use a neural network to transform a laser spatial intensity profile into an equivalent scanning electron microscope image of the laser-machined target. This approach enables the simulated visualization of the result of laser machining with any laser spatial intensity profile, and hence demonstrates predictive capabilities for laser machining. The trained neural network was found to have encoded functionality that was consistent with the laws of diffraction, hence showing the potential of this approach for discovering physical laws directly from experimental data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52032460,"openaccessinfo":{"externalids":{"MAG":"2809096091","ACL":null,"DOI":"10.1364\/OE.26.017245","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Three new lithium salts, lithium difluoro-2-methyl-2-fluoromalonatoborate (LiDFMFMB), lithium difluoro-2-ethyl-2-fluoromalonatoborate (LiDFEFMB), and lithium difluoro-2-propyl-2-fluoromalonatoborate (LiDFPFMB), have been synthesized and evaluated for application in lithium ion batteries. These new salts are soluble in a mixture of ethylene carbonate (EC) and ethyl methyl carbonate (EMC) (1\u2006:\u20062 by wt) and 1.0 M salt solutions can be easily prepared. The ionic conductivities of these new salts are close to those of LiBF4 and LiPF6. Cyclic voltammograms reveal that these new salt based electrolytes can passivate both natural graphite and high voltage spinel LiNi0.5Mn1.5O4 (LNMO) to form effective solid electrolyte interphases (SEIs). In addition, these new salt-based electrolytes exhibit good cycling stability with high coulombic efficiencies in both LiNi0.5Mn1.5O4 and graphite based half-cells and full cells.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100124575,"openaccessinfo":{"externalids":{"MAG":"2558291488","ACL":null,"DOI":"10.1039\/C6TA07757A","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Baseball is unique in its multiple facets: pitching, hitting, base rounding, and fielding are distinct activities that require different athletic skills to perform at a high level. Likewise, these different aspects of the game can contribute to a multitude of varying injuries. While high-velocity overhead throwing, along with batting, can produce a plethora of upper extremity injuries that often garner attention, injuries to the lower extremity can severely impact a player's performance and ability to compete. The rigors of the short, explosive sprinting required for base running, as well as the dynamic movement required for fielding, create ample opportunity for lower limb injury, and even subtle pathology can affect a pitcher's ability to perform or increase their long-term risk of injury. Chronic injury from conditions such as femoroacetabular impingement and hip labral tears can also occur. The purpose of the present review is to summarize the relevant epidemiology, pathophysiology, and treatment of lower extremity injuries in baseball athletes, with reference to current research into the prevention and management of such injuries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":246669564,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/20503121221076369","PubMedCentral":"8832566","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1177\/20503121221076369","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Deep face recognition (FR) has achieved significantly high accuracy on several challenging datasets and fosters successful real-world applications, even showing high robustness to the illumination variation that is usually regarded as a main threat to the FR system. However, in the real world, illumination variation caused by diverse lighting conditions cannot be fully covered by the limited face dataset. In this paper, we study the threat of lighting against FR from a new angle, i.e., adversarial attack, and identify a new task, i.e., adversarial relighting. Given a face image, adversarial relighting aims to produce a naturally relighted counterpart while fooling the state-of-the-art deep FR methods. To this end, we first propose the physical modelbased adversarial relighting attack (ARA) denoted as albedoquotient-based adversarial relighting attack (AQ-ARA). It generates natural adversarial light under the physical lighting model and guidance of FR systems and synthesizes adversarially relighted face images. Moreover, we propose the auto-predictive adversarial relighting attack (AP-ARA) by training an adversarial relighting network (ARNet) to automatically predict the adversarial light in a one-step manner according to different input faces, allowing efficiency-sensitive applications. More importantly, we propose to transfer the above digital attacks to physical ARA (PhyARA) through a precise relighting device, making the estimated adversarial lighting condition reproducible in the real world. We validate our methods on three state-of-the-art deep FR methods, i.e., FaceNet, ArcFace, and CosFace, on two public datasets. The extensive and insightful results demonstrate our work can generate realistic adversarial relighted face images fooling face recognition tasks easily, revealing the threat of specific light directions and strengths.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":237194719,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2108.07920"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There is a need for systems to provide additional processing to extract useful information from the growing amounts of data. High Performance Computing (HPC) techniques use large clusters comprised of commodity hardware and software to provide the necessary computation when a single machine does not suffice. In addition to the increase in data, there have been other architectural changes like the advent of multicore and the presence of multiple networks on a single compute node, yet the commodity transport protocols in use have not adapted. It is therefore an opportune time to revisit the question of which transport features are necessary in order to best support today's applications. Popular in HPC, we use the Message Passing Interface (MPI) to provide support for large scale parallel applications. We propose features to the transport protocol to overcome the problems with reliability, performance, and design simplicity existing in Ethernet-based commodity clusters. We use the Stream Control Transmission Protocol (SCTP) as a vehicle to implement tools having the proposed transport features for MPI. We develop several SCTP-based MPI implementations, a full-featured userspace SCTP stack, as well as enable the execution of unmodified MPI programs over a simulated network and SCTP implementation. The tools themselves provide the HPC and networking communities means to utilize improved transport features for MPI by way of SCTP. The tools developed in this thesis are used to show that the proposed transport features enable further capabilities regarding the performance, reliability, and design simplicity of MPI applications running on Ethernet-based cluster systems constructed out of commodity components.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":56840835,"openaccessinfo":{"externalids":{"MAG":"2304149071","ACL":null,"DOI":"10.14288\/1.0052018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The process of local economic development is extremely complex. Different authors diversely aggregate its concept, objectives and actors. According to the literature local economic development is an intervention to the functioning of the economy. Its purpose is to ensure sustainable local development and to increase the standard of living. The intervention requires the involvement of many actors, who approach the process from various sides. But the instruments, which are used by them, are very similar. In this paper I will make a short overview of the instruments of local economic development, then I will analyse the practice of Vienna.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55169889,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Granule cells in the dentate gyrus (DGgc), a brain region important for spatial learning, are part of the engrams formed when an animal explores a new context. Previous work showed that modulation of DGgc activity by perisomatic inhibition bidirectionally regulates memory encoding. Whether this result is due to a differential recruitment of experience-relevant neuronal assemblies or the functional connectivity between them, is not yet known. We combined pharmacogenetic tools (DREADDs) to increase or decrease the activity of parvalbumin (PV)-interneurons in DG while mice encoded spatial information in the Novel Object Location task (NOL). Sixty min after memory encoding in the NOL task animals were sacrificed and their brains processed and quantified for c-Fos staining. Exploration in the NOL task induced a robust increase in the number of c-Fos+ cells across hippocampal subfields. However, the number of c-Fos+ cells, both in the hippocampus and extra-hippocampal structures like the medial prefrontal cortex (mPFC) and the nucleus accumbens, was constant regardless of the inhibitory tone in the DG. Only a moderate increase in c-Fos intensity per cell in DGgc was found in the PV-cell inhibition group. In contrast, we found a significant increase in the correlation between the number of c-Fos+ cells in all quantified neuronal assemblies during PV-inhibition, and a decrease during activation. Together, these data reveal a critical regulatory role of perisomatic inhibition in the dentate gyrus in binding experience-relevant neuronal assemblies in memory.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":225776315,"openaccessinfo":{"externalids":{"MAG":"3043667695","ACL":null,"DOI":"10.14293\/s2199-1006.1.sor-.ppnyd9f.v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.scienceopen.com\/document_file\/57357389-f6fb-4029-8ea1-efa4803bcd6d\/ScienceOpen\/Raquel_FENS_2020_updated.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"High-frequency and -field electron paramagnetic resonance (HFEPR), in its current configuration (frequencies up to 1THz; fields up to 35T), has been applied to transition metal complexes for over twenty years, whilst early examples of this technique go back nearly fifty years. In this Report are described HFEPR (limited to frequencies above those generated by most commercial instruments) studies on paramagnetic transition metal ion molecular complexes. These coordination complexes are chiefly of the d block ions, and specifically 3d (first row transition metals), but selected examples of studies on 4d, 5d and 4f ions will also be discussed. The period from 2006 will primarily be covered with an emphasis on results reported within the last several years. The subject emphasis will be on mono- or dinuclear complexes; however, polynuclear systems will also be reviewed. Computational\/theoretical studies that are closely related to experimental work will be described as well. Speculation as to new targets for application of HFEPR within this general area will be entertained throughout the Report.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":2,"2024-26":1}},"corpusid":94040810,"openaccessinfo":{"externalids":{"MAG":"1819858826","ACL":null,"DOI":"10.1039\/9781849734837-00209","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper deals with the homogeneous Cayley-Laplace differential operator on the space of rectangular real matrices. Using Riesz potentials, we obtain fundamental solutions for this operator and some of its powers. We establish that the Cayley-Laplace operator satisfies the strong Huygens principle. Using intertwining operators with spectral parameters, we consider deformations of the Cayley-Laplace operator and find sufficient conditions under which these deformations satisfy the strong Huygens principle.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123032125,"openaccessinfo":{"externalids":{"MAG":"2067055540","ACL":null,"DOI":"10.1070\/IM2005V069N01ABEH000528","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bonek refers to Persebaya (Surabaya local football club) supporters who are notorious for their anarchist behavior (bullying, fighting among certain football fans, breaking stadium facility). Whenever Persebaya plays, these Bonek are always present to support their favourite team, except in some occassions when they are not allowed to come to the stadiums by the national football comittee for their reckless behavior. We can identify Bonek easily as they usually wear a certain apparel green shirts with various pictures and words showing their support to their beloved team. This research aims to reveal certain ideology of words and pictures printed on Bonek shirts worn by them in the match. We are curious to know whether the shirt took part in shaping what they are and what they can do. In addition to the Barthesian semiotics used to analyze the data, we interviewed some Bonek to support our analysis. The study finds that the symbols printed on Bonek shirt represent the ideology of heroism derived from 'Bung Tomo' spirit during the colonial war againts the Dutch. Another ideologiocal reading reveals that the myth of heroism serves as an alibi of mass movement which often 'justifies' the way Bonek supporters conduct 'unpleasant' or reckless behaviors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110476596,"openaccessinfo":{"externalids":{"MAG":"2176122171","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Models of the universe with additional (non-gravitational) interaction between the components of the cosmic fluid\u2014the phantom energy and the background\u2014are investigated. A general form of the interaction that is inspired by scalar\u2013tensor theories of gravity is considered. No specific model for the phantom fluid is assumed. We concentrate our investigation on solutions which are free of the coincidence problem. Solutions with constant and dynamical equation-of-state parameters are studied separately. In the last case the model allows for smooth transition from dust in the past into phantom in the future. We found a wide region in the parameter space where the solutions are also free of big rip singularity. Physical arguments, together with arguments based on the analysis of the observational evidence, suggest that phantom models without the big rip singularity might be preferred by nature.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":9641827,"openaccessinfo":{"externalids":{"MAG":"2169817570","ACL":null,"DOI":"10.1088\/0264-9381\/23\/5\/010","PubMedCentral":null,"ArXiv":"astro-ph\/0502141"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/astro-ph\/0502141","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We give a generalized definition of stretch that simplifies the efficient construction of lowstretch embeddings suitable for graph algorithms. The generalization, based on discounting highly stretched edges by taking their pth power for some 0 < p < 1, is directly related to performances of existing algorithms. This discounting of high-stretch edges allows us to treat many classes of edges with coarser granularity. It leads to a two-pass approach that combines bottom-up clustering and top-down decompositions to construct these embeddings in O(m log log n) time. Our algorithm parallelizes readily and can also produce generalizations of low-stretch subgraphs.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":18641481,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Effects of 3 MeV electron (10 mA) irradiation at room temperature on the phase, microstructure, electrical and life time properties of 4H-SiC wafer were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), four point probe current-voltage measurements and positron annihilation spectroscopy. It was found that irradiation damage in SiC wafer is significantly increased with the increase of radiation dose as observed in SEM. Irradiation also resulted in modification of crystallite size as identified by XRD. The resistance of a sample before irradiation was found to be 0.8 M\u03a9, whereas for a sample irradiated at 200 kGy, the resistance as measured by four point probe was 5.2 M\u03a9. It seems that the increase of resistance hence,\u00a0 reduction in conductivities could be due to defects induced by the radiation dose received then created leakage currents at both reverse and low-forward biases and creation of traps in the SiC. Meanwhile positron annihilation spectroscopy (PAS) was used to analyse the life time of irradiated samples which nonetheless shows that all irradiated sample have similar life time of 151 ps. It was observed that that no degradation process of materials experienced by SiC wafer irradiated at 500 kGy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":139307633,"openaccessinfo":{"externalids":{"MAG":"2889714486","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background The neglected tropical disease Buruli ulcer (BU) caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic ulcerative skin lesions. Histopathological features are progressive tissue necrosis, extracellular clusters of acid fast bacilli (AFB) and poor inflammatory responses at the site of infection. After the recommended eight weeks standard treatment with rifampicin and streptomycin, a reversal of the local immunosuppression caused by the macrolide toxin mycolactone of M. ulcerans is observed. Methodology\/Principal Findings We have conducted a detailed histopathological and immunohistochemical analysis of tissue specimens from two patients developing multiple new skin lesions 12 to 409 days after completion of antibiotic treatment. Lesions exhibited characteristic histopathological hallmarks of Buruli ulcer and AFB with degenerated appearance were found in several of them. However, other than in active disease, lesions contained massive leukocyte infiltrates including large B-cell clusters, as typically found in cured lesions. Conclusion\/Significance Our histopathological findings demonstrate that the skin lesions emerging several months after completion of antibiotic treatment were associated with M. ulcerans infection. During antibiotic therapy of Buruli ulcer development of new skin lesions may be caused by immune response-mediated paradoxical reactions. These seem to be triggered by mycobacterial antigens and immunostimulators released from clinically unrecognized bacterial foci. However, in particular the lesions that appeared more than one year after completion of antibiotic treatment may have been associated with new infection foci resolved by immune responses primed by the successful treatment of the initial lesion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8439035,"openaccessinfo":{"externalids":{"MAG":"2063586473","ACL":null,"DOI":"10.1371\/journal.pntd.0001252","PubMedCentral":"3149035","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosntds\/article\/file?id=10.1371\/journal.pntd.0001252&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper is devoted to the improvement of semi-physical fire spread models. In order to improve them, a theoretical approach based on the multiphase concept was carried out. The multiphase approach which considers the finest physical phenomena involved in fire behaviour was reduced by making several assumptions. This work led us to a simplified set of equations. Among these, a single equation for the thermal balance was obtained by using the thermal equilibrium hypothesis. This approach has been applied to the improvement of our semi-physical model in order to take into account increasing wind influence. The predictions of the improved model were then compared to experimental data obtained for fire spread conducted across pine needle fuel beds. To this end, different slope values and varying wind velocities were considered. The experimental tendency for the variation of the rate of spread was predicted. Indeed, it increases with increasing wind velocity for a given slope as well as for a given wind with increasing slope.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55575907,"openaccessinfo":{"externalids":{"MAG":"2156703132","ACL":null,"DOI":"10.1080\/00102200108952137","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.pure.ed.ac.uk\/ws\/files\/12098287\/CST_Simeoni.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"A systematic study of the microstructure and mechanical properties of zirconium-hydrogen alloys formed from the a-phase region under a variety of cooling conditions has been made. The tensile properties of these alloys, at room temperature and at a variety of strain rates, has been related to their microstructure in terms of volume fractions and nature of the hydride phases present. Nomarski Differential Interference Microscopy has been used to make detailed optical examinations of hydride morphology in unetched specimens and the hydride phases Q and Y have been identified unambiguously, even when present in low concentrations, by means of a Nonius Guinier quadruple focussing X-ray camera technique. The microstructure and constitution of the alloys has been found to vary with increases in cooling rate from the solid solution phase field and it has been shown that while slow cooling favours precipitation mainly at grain boundary sites, increases in cooling rate favour the formation of Widmanstatten structures. It has also been shown that slow cooling favours the precipitation reaction alpha \u2192 alpha+delta while increases in cooling rate progressively favour the reaction alpha \u2192 alpha + gamma. The magnitude of the effect of hydride on the mechanical properties of zirconium-hydrogen alloys has been shown to depend more on the volume fraction of the second phase than on its nature. It has been shown that low strain failures may be associated with the presence of continuous networks of hydride throughout the specimens and in these cases it has been demonstrated that there is no significant difference between the embrittling effects of the hydride phases Q and Y. It has been found that the presence of a triaxial stress system markedly reduces the strains to failure in these alloys and that specimens which normally fail at plastic strains of about 10% may be made to do so after about 1% strain in the presence of a notch.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140059750,"openaccessinfo":{"externalids":{"MAG":"2887366356","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Despite serving as the foundation models for a wide range of NLP benchmarks, pre-trained language models have shown limited capabilities of acquiring implicit commonsense knowledge from self-supervision alone, compared to learning linguistic and factual knowledge that appear more explicitly in the surface patterns in text. In this work, we introduce commonsense knowledge transfer, a framework to transfer the commonsense knowledge stored in a neural commonsense knowledge model to a general-purpose pre-trained language model. It first exploits general texts to form queries for extracting commonsense knowledge from the neural commonsense knowledge model and then refines the language model with two self-supervised objectives: commonsense mask infilling and commonsense relation prediction, which align human language with the underlying commonsense knowledge. Empirical results show that our approach consistently improves the model's performance on downstream tasks that require commonsense reasoning. Moreover, we find that the improvement is more significant in the few-shot setting. This suggests that our approach helps language models better transfer to downstream tasks without extensive supervision by injecting commonsense knowledge into their parameters.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":247601337,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2306.02388","PubMedCentral":null,"ArXiv":"2306.02388"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Montevideo Bay is an extremely polluted coastal system because of multiple sources of contamination from industrial manufacturing, urban activities, energy production, harbor operations and population increase. Because rehabilitation measures will be implemented, this research project was undertaken to assess the contamination of the system. A sediment core that spanned to 3000 yr BP was taken to reconstruct the Holocene natural changes in salinity and trophic state, and also the effect of human activities on the environmental quality of the system. Before the human impact, the system was controlled by a sea level decrease, during which an increase in trophic state was observed. After the human impact, an intensification of the eutrophication process was observed, mainly due to the industrial activities linked to lack of sanitation. In addition, sharp increases in heavy metal concentration were recorded after 1917, when the leather tanning activities together with the construction and operation of the oil refinery and the thermoelectric generation plant were first documented. Thus, the data presented in this paper provide important chronological evidence of human impacts and environmental degradation, which at the minimum can be used to advise the managers and government agencies about the consequences of bad environmental practices on coastal aquatic systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54996664,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A comprehensive review of the scientific literature on the possible benefits of CBD, describing findings from both preclinical and human clinical studies. CBD (cannabidiol), a nonintoxicating compound derived from the cannabis plant, can be found in products ranging from lotion and smoothies to chewable gummies and pet treats. It's been promoted\u2014but not always scientifically validated\u2014as a treatment for medical conditions including psychosis, anxiety, pain, and even cancer. In this book, three leading cannabis researchers look at the science of CBD, offering a comprehensive review of the scientific literature on the possible benefits of CBD and describing their findings from both preclinical and human clinical studies.\n As it turns out, the current CBD fad has some basis in preclinical animal research that indicates potential beneficial effects. Clinical studies, hampered by regulations governing research with cannabis, have lagged behind the basic animal research. The authors examine what research shows about chemical and pharmacological aspects of CBD and CBD's interaction with THC, the main psychotropic compound found in cannabis. They go on to review the current state of knowledge about CBD's effectiveness in treating epilepsy, cancer, nausea, pain, anxiety, PTSD, depression, sleep disorders, psychosis, and addiction.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":251333350,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.7551\/mitpress\/13686.001.0001","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.7551\/mitpress\/13686.001.0001","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The effect of CO2 partial pressure on ethanol dry reforming was evaluated over 5%Ce-10%Co\/Al2O3 catalyst at = PCO2 = 20-50 kPa, PC2H5OH = 20 kPa, reaction temperature of 973 K under atmospheric pressure. The catalyst was prepared by using impregnation method and tested in a fixed-bed reactor. X-ray diffraction measurements studied the formation of Co3O4, spinel CoAl2O4 and CeO2, phases on surface of 5%Ce-10%Co\/Al2O3 catalyst. CeO2, CoO and Co3O4 oxides were obtained during temperature\u2013programmed calcination. Ce-promoted 10%Co\/Al2O3 catalyst possessed high BET surface area of 137.35 m2 g-1. C2H5OH and CO2 conversions was improved with increasing CO2 partial pressure from 20-50 kPa whilst the optimal selectivity of H2 and CO was achieved at 50 kPa.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":240211997,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.53894\/ijirss.v1i1.3","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"http:\/\/www.ijirss.com\/index.php\/ijirss\/article\/download\/3\/105","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract. A new type of oscilliton (soliton with superimposed spatial oscillations) is described which arises in plasmas if the electron cyclotron frequency \u03a9 e is larger than the electron plasma frequency \u03c9 e , which is a typical situation for auroral regions in planetary magnetospheres. Both high-frequency modes of concern, the Langmuir and the whistler wave, are completely decoupled if they propagate parallel to the magnetic field. However, for oblique propagation two mixed modes are created with longitudinal and transverse electric field components. The lower mode (in the literature commonly called the whistler mode, e.g. Gurnett et al., 1983) has whistler wave characteristics at small wave numbers and asymptotically transforms into the Langmuir mode. As a consequence of the coupling between these two modes, with different phase velocity dependence, a maximum in phase velocity appears at finite wave number. The occurrence of such a particular point where phase and group velocity coincide creates the condition for the existence of a new type of oscillating nonlinear stationary structure, which we call the whistler-Langmuir (WL) oscilliton. After determining, by means of stationary dispersion theory, the parameter regime in which WL oscillitons exist, their spatial profiles are calculated within the framework of cold (non-relativistic) fluid theory. Particle-in-cell (PIC) simulations are used to demonstrate the formation of WL oscillitons which seem to play an important role in understanding electron beam-excited plasma radiation that is observed as auroral hiss in planetary magnetospheres far away from the source region.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":29761893,"openaccessinfo":{"externalids":{"MAG":"2070922715","ACL":null,"DOI":"10.5194\/ANGEO-29-1739-2011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The transfer of humorous elements in audio-visual texts is a challenging task as verbal expressions heavily rely on witty wordplay and are visually bound. To overcome such a challenge, the translator has to have two particular skills: creativity and a thorough understanding of the context and\/or intended meanings. This paper aims at investigating the realisation of humour in dubbing animation vis-\u00e0-vis register variation and creativity by comparing the Egyptian dub with the Modern Standard Arabic (MSA) re-dub of Disney's Monster's Inc . Drawing on House's (2015) translation quality assessment model, the data analysis reveals that resorting to colloquialism as a covert translation strategy provided a functionally adequate, nuanced leeway for the translator to capture the essence situational humour of the source text by relying on the on-screen visuals. Therefore, the translator quasi-assumes the role of an author to communicate interpersonal meanings as effectively and humorously as possible. Meanwhile, resorting to the standard variation as an overt translation strategy significantly deflated and sacrificed verbal humour due to the translator's literal style and Al-Jazeera's ideological orientation that shuns functional equivalence for the sake of linguistic homogenisation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252879540,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Harapan region is governed by a web of regulations. The corresponding allocation of land is informed by the demands of the international market and Indonesia's policy to supply it with the products needed. Thus, human interactions with the rainforest transformation systems are largely determined by external economic drivers. Taking the anthropology of globalization as a starting point, our paper outlines the relationships between international demands, state regulations, the allocation of land, and the way local people, whose rights have been disregarded for decades, and migrants make use of it locally, often in conflict with the state and concession holders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":202235010,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rationale In the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 strategy document, assessment of symptoms is advised to be performed by the Clinical COPD Questionnaire (CCQ), COPD Assessment Test (CAT), or modified Medical Research Council (mMRC). Cut points of resp. CCQ\u22651, CAT\u226510 and mMRC\u22652 indicate highly symptomatic patients (groups B and D). Recently a cut point of \u226525 of the St. George Respiratory Questionnaire (SGRQ) has been suggested as gold standard.1 The current study investigates the criterion validity of CCQ, CAT and mMRC using the advised cut point of SGRQ based on sensitivity and specificity analysis. Methods Two datasets were used: A) 238 patients participated in a 3-week Pulmonary Rehabilitation (PR) program (63% male, 51%FEV1pred., 40 mean packyears, 57 mean age, 40\/39\/21% GOLD stage II\/III\/IV) and B) 90 patients from primary care2, 90% male, 56%FEV pred., 1 16\/47\/30\/6% GOLD I\/II\/III\/IV. Primary outcome is the correspondence between recommended cut point of the SGRQ, CCQ, CAT and mMRC expressed in sensitivity and specificity using receiver operating characteristic (ROC) curves. Taking into account the possibility of unsatisfactory sensitivity and specificity, scatterplots with regression lines were used to visually explore alternative cut points, which were consecutively evaluated using ROC curves. Results Mean total CCQ, CAT, SGRQ scores and median mMRC: dataset A: resp. 2.9, 20.2, 50.1, and 2, and dataset B: 1.6, 14.1, 36.3, and 2. The table shows ROC analysis results using the suggested SGRQ cut point of 25. Visual inspection of the scatterplots revealed that SGRQ=20 might serve as more corresponding cut point, with ROC results in the table. This was confirmed by regression analysis. Conclusions In these two samples the suggested cut point for the SGRQ (\u226525) does not seem to correspond well to the established cut points of both the CCQ and CAT, resulting in low specificity levels, the correspondence with mMRC seems satisfactory for the rehabilitation sample. A SGRQ threshold of \u226520 shows good sensitivity and specificity for CCQ and CAT, as well as improved specificity for the mMRC. This value corresponds better to established cut points for CCQ, CAT and mMRC in both patient groups. (Table Presented).","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":78865038,"openaccessinfo":{"externalids":{"MAG":"2478834915","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study is to investigate effects of the adoption of ICT facilities on service delivery in federal university libraries in Nigeria. With the advent of Information and Communication Technologies, provision of library services to users has considerably changed. As a result of these changes, library users are expected to witness changes in search of their day to day information needs in the library for maximum satisfaction. In order to be enterprising, library professionals have fully incorporated the use of ICT facilities in their operation and services. The study was purposively determined level of adoption of ICT facilities and services were survey research designed was adopted using the population of Two hundred and Seventy three (273) librarians as the sample size for the study. Data collection was carried out using questionnaire as an instrument where data analysis was done using frequency counts for answering research questions while hypothesis was tested using chi-square. The study found adequate level of adopted ICT facilities and library services in first-generation federal university libraries and concluded that since the findings of the study indicates a relationship between the level of facilities and services (including educational services) provided, the need for substantial investment in ICT and continuous upgrading of existing facilities and training become imperative for optimal benefits of modern education. The study finally recommended that; librarians should be given adequate and continuous training to effectively operate the ICT facilities.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":262102491,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.47524\/jlst.v5i2.73","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.47524\/jlst.v5i2.73","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Arguably one of the most important components of cognitive-behavioural counselling occurs after the client has finished a counselling session when they attempt to convert their goals identified in the clinic into positive behaviour change. However, clients often struggle to implement and complete treatment plans because of difficulties with self-management. Motivated by the increasing demand for evidence of the effectiveness for therapeutic interventions, this study aimed to evaluate a collaboratively designed self-management program using a single-case experimental design with baseline, intervention and 6-month post-intervention follow-up to help a mature-aged individual begin and maintain a higher intensity fitness regime. The dependent variables were distance and time with the goal being able to run 5km non-stop within 30 minutes. After the intervention phase the participant was able to increase his running distance from a baseline mean of 1.36km to the 5km goal in 30 minutes, remaining injury free. Setting targets and making them public appeared to play a role in motivating the participant to complete goals. The explanatory force for adherence to the self-directed program may provide insights in other areas of behaviour, such as compliance with pharmaceutical and dietary regimes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":149426868,"openaccessinfo":{"externalids":{"MAG":"2773522552","ACL":null,"DOI":"10.1080\/21507686.2017.1411375","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In situ organic matters, such as Mucuna sp., Flemingia sp., and plant residues differ in quality (in terms of lignin, cellulose and nutrients contents). Such difference determines soil organic matter content especially labile fraction that could effect on soil properties. The aims of this research were to study: 1) the effects of various sources and quality of organic matters on soil organic fraction, and 2) the relationships between the changes of particulate organic matter and C-microbes (POM and Cmic) and soil quality indicators. The experiments were conducted in greenhouse of the Center for Soil and Agroclimate Research and Development, Bogor, from January to May 2003. The factorial completely randomized design was used with three replications. The first factor was the method of organic matters application: 1) mulch on soil surface and 2) incorporated with soils. The second factor was the sources of organic matters (dosage in equvalent with 2% organic C), i.e: 1) Mucuna sp., 2) Flemingia sp., 3)maize residue, 4) mixture of Mucuna sp., and Flemingia sp., 5) mixture of Flemingia sp. and maize residue, 6) mixture of Mucuna sp. and maize residue, and 7) mixture of Mucuna sp., Flemingia sp., and maize residue. The results showed that on organic matter application with incorporated method, C\/N ratio and lignin content of organic matter have positive correlation with organic C, Cmic and Cmic\/Corg, but have negative correlation with POMp. The changes of soil qualities caused by short term organic matter application could be seen from the changes of labile fraction of organic matter. When organic matter was incorporated, POMtand POMt\/Corg have positive correlation with bulk density, but have negative correlation with RPT, PDC, available K, and total- N. When organic matter was spreaded on the soil surface, Cmic has positive correlation with available P. The changes on labile fraction (Cmic and POMt) was easy to be detected in short period, thus the changes of physical characteristics and the availability of macro nutrients is easy to be predicted.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":103496457,"openaccessinfo":{"externalids":{"MAG":"2737817274","ACL":null,"DOI":"10.2017\/jti.v0i26.246","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Diabetic retinopathy is a disease caused by complications of chronic diabetes and can lead to blindness. Therefore, automatic detection of microaneurysms on retinal fundus images as an early warning system is very necessary and challenging since the size of the microaneurysm is very small compared to the anatomical structures of the retina such as blood vessels and other elements, and hemorrhages as other red lesions. In this study, we propose a novel deep learning network that modifies UNet using residual units with modified identity mapping (MResUNet) to perform microaneurysm segmentation. The purpose of identity mapping modification using convolutional layers and batch normalization is to enrich features and add Residuals in UNet to overcome feature degradation as the network becomes deeper. The mean weighted loss function is used in training to solve the problem of pixel imbalance between the microaneurysms and the background. The proposed architecture is evaluated using the IDRID and DiaretDB1 datasets. The experimental results show that the proposed architecture (MResUNet) achieves higher sensitivity values of 61.96% and 85.87% on the IDRID and DiaretDB1 datasets, respectively, compared to AutoEncoder, FCN16, FCN8,","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":235514011,"openaccessinfo":{"externalids":{"MAG":"3158309449","ACL":null,"DOI":"10.22266\/IJIES2021.0630.30","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper demonstrates a CMOS Ring Voltage Controlled Oscillator (RVCO) whose oscillation frequency is insensitive to supply noise. Our RVCO achieves this with on-chip adaptive bias-current and voltage-swing control. A prototype RVCO is fabricated with 0.13um CMOS technology and it achieves static supply voltage sensitivity of 0.013%-fvco<\/inf>\/1%-Vdd<\/inf> and dynamic sensitivity of 0.08%-fvco<\/inf>\/1%-Vdd<\/inf>.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":336570,"openaccessinfo":{"externalids":{"MAG":"2106643491","ACL":null,"DOI":"10.1109\/ISCAS.2011.5937543","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper considers the implications of habit formation and financial frictions for the propagation of macroeconomic shocks. In a model that is capable of matching asset pricing moments, a short-lived shock that destroys a small fraction of the economy's stock of pledgeable collateral generates a persistent recession, a stock market crash, and a flight-to-safety effect. This novel mechanism creates a tight link between the asset pricing implications of macroeconomic models and their ability to propagate and amplify the effects of macroeconomic shocks.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":44062676,"openaccessinfo":{"externalids":{"MAG":"2620413028","ACL":null,"DOI":"10.1093\/JEEA\/JVX015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Absorption and photoluminescence (PL) spectra, PL quantum efficiency, and PL lifetime have been investigated on bis(8-hydroxyquinoline) zinc (Znq2) and magnesium (Mgq2) in solutions and powder. Znq2 and Mgq2 have the lowest-energy absorption band at 376 and 396 nm in acetonitrile solution, respectively, and emission band with peak at 555 and 480 nm. The PL quantum efficiency is 0.03 and 0.45 for Znq2 and Mgq2 in the solution, respectively, while 0.45 and 0.36 in powder. Unlike the case of powders, two PL lifetimes are obtained in solutions. The longer lifetime is attributed to molecule having interaction with its neighboring molecule, while the shorter one to the isolated single molecule.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":101433175,"openaccessinfo":{"externalids":{"MAG":"2322797482","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In Gleyzes-Langlois-Piazza-Vernizzi (GLPV) scalar-tensor theories, which are outside the domain of second-order Horndeski theories, it is known that there exists a conical singularity in the case where the parameter $\\alpha_{\\rm H}$ characterizing the deviation from Horndeski theories approaches a non-vanishing constant at the center of a spherically symmetric body. Meanwhile, it was recently shown that second-order generalized Proca theories with a massive vector field $A^{\\mu}$ can be consistently extended to beyond-generalized Proca theories, which recover the shift-symmetric GLPV theories in the scalar limit $A^{\\mu} \\to \\nabla^{\\mu} \\chi$. In beyond-generalized Proca theories up to quartic-order Lagrangians, we show that the conical singularity is generally absent due to the existence of the temporal vector component. We also derive the vector-field profiles around a compact object and show that the success of the Vainshtein mechanism operated by vector Galileons is not prevented by the new interaction in beyond generalized Proca theories.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":125422295,"openaccessinfo":{"externalids":{"MAG":"2509453141","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper proposed a control simulation method for design and verification of the transport system in an automobile assembly line based on digital manufacturing system. The design of the transport system involves two major activities: mechanical design (device specification) and electrical design (device behavior and system control). Conventionally, the simulation and emulation system of the transport system focuses on the abstract level, which mainly deals with design verification, alternative comparison, and system diagnosis. Although it can provide overall system visibility in monitoring how well it works in the process and view, its simulation models are not sufficiently realistic to be used for a detailed design or for implementation purposes. In this paper, a digital simulation model for a transport system in an automotive assembly line is constructed by adapting a digital manufacturing methodology. We use the concept of the \"Virtual Probe\", which transport a carrier instead of the belt of the conveyor. In conclusion, the proposed method is valuable in the process of test run in the shop floor. This method would reduce the time and effort for validating the manufacturing system and improve the productivity and integrity of the control program.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110926866,"openaccessinfo":{"externalids":{"MAG":"2212504917","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to explore barriers to access in health services among small islands in Makassar City. \nThis research is qualitative research through content analysis by observing phenomena that occur based on \nthe accessibility framework of Levesque, et.al. Data collection was carried out through in-depth interviews \nwith 8 key informants and 9 other informants (n = 17). \nThis study found that geographical factors (distance, travel time, and transportation costs) were the main \nconsiderations in utilizing primary health services in the small island communities around Makassar City \nwhich were predominantly fishermen. The two closest islands (Barrang Caddi and Bone Tambung), have \nenjoyed easy access and free service for Universal Health Coverage (UHC) achievements. \nIt is different from the outer islands, especially Langkai and Lanjukang, although most of the residents \nalready have National Health Insurance (NHI) they have difficulty using their cards due to geographical \nconstraints. Moreover, fishermen often go fishing for days, becoming another obstacle in accessing quality \nhealth facilities available in Makassar City. \nVarious efforts have been made by the Makassar City Health Office to address the disparity in health \nservices in the islands in Barrang Caddi, such as the use of sea ambulances, and regular visits. The marine \nambulance is only one ship on standby between two public health centers in another village office if there is \nan emergency patient who must be referred to a hospital in Makassar City. \nThis disparity in access to health services triggers injustice among residents of the islands in the Makassar \nCity area. Very contractual with the slogan: \"Makassar City of the World\". \nThis study revealed a special transportation need in the form of a very simple capacity sea ambulance and \nmanaged by island community communities that are not reached by sea ambulances from the public health \ncenter.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":225458217,"openaccessinfo":{"externalids":{"MAG":"3091953812","ACL":null,"DOI":"10.37506\/MLU.V20I3.1513","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Three experiments investigated the effects of immediate and delayed postsession feeding on progressive-ratio and variable-interval schedule performance in rats. During Experiments 1 and 2, immediate postsession feeding decreased the breakpoint, or largest completed ratio, under progressive-ratio schedules. Experiment 3 was conducted to extend the results of the first two experiments to responding maintained by variable-interval schedules with different session lengths (15 and 60 min). Response rates decreased in all 4 subjects when postsession feeding immediately followed a 15-min session and in 3 of 4 subjects when postsession feeding immediately followed a 60-min session. The implications of this research are twofold: (1) The functional context in which within-session reinforcers are embedded extends outside the experimental chamber, and (2) supplemental postsession feedings should be sufficiently delayed from the end of a session to avoid weakening operant behavior in the experimental sessions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7633956,"openaccessinfo":{"externalids":{"MAG":"2151860893","ACL":null,"DOI":"10.1901\/jeab.2012.97-203","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3292231\/pdf\/jeab-97-02-203.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We studied survival, growth and morphological characters in the offspring of native hatchery and wild-born anadromous brown trout (Salmo trutta) and their hybrids (wild-born female x hatchery male and wild-born male x hatchery female) in a 1-year field experiment. We also conducted laboratory studies where we examined social interactions between the offspring of the same hatchery and wild-born trout. All offspring were raised in a hatchery and nose tagged before being released into the stream. In total, 1125 individuals were released into the stream (1999) and a total of 614 individuals were recovered (2000). We found no differences in growth and survival between the offspring of hatchery, wild-born and hybrid trout. Morphology was also similar among groups, where only 38% females and 36% males were classified into the right category, which were only 12% better than random classification. In the laboratory experiment, we compared only the offspring of hatchery and wild-born trout with respect to growth, dominance, aggressiveness, feeding and activity. We found small differences between the offspring of hatchery and wild-born fish with respect to growth but this effect was not found in the field experiment. Our result suggests that the offspring of hatchery trout and hybrids between hatchery and wild-born trout performed equally well to the offspring of wild-born trout.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":84287741,"openaccessinfo":{"externalids":{"MAG":"2041654565","ACL":null,"DOI":"10.1111\/J.1600-0633.2006.00150.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Graphene was synthesized by the chemical vapor deposition (CVD). Initially ratios of Ar, H2 and CH4 gases were optimized to get a single layer graphene by CVD. Raman characterizations showed that the optimized synthesis conditions provided I2D\/IG ratio as 3 that this ratio indicated the formation of the single layer graphene. The synthesized single layer graphene was mixed with melamine at the certain ratios to obtain the graphene\/graphitic-C3N4 (g-C3N4) semiconductor composites. All the synthesized composites were prepared as the photo-electrode to be used in the photo-assisted charging of the lithium-ion oxygen battery. The photo-current levels produced by the photo-electrodes were determined by the linear sweep voltammetry technique.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247494285,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.55549\/epstem.1068583","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"http:\/\/www.epstem.net\/tr\/download\/article-file\/2234102","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Pharmacokinetic studies of 5-FU in normal and Sarcoma 180-bearing mice were performed, and the following results obtained: When the administered dose of 5-FU was increased, it was found that there was an increase in the half-life and AUC (area under the concentration curve) and a lower rate of plasma clearance. When the drug was administered at equal doses of 40 mg\/kg, the rate of clearance was high in the order of p.o. greater than continuous infusion greater than i.v. bolus. When Sarcoma 180-bearing mice were injected with CCl4 to induce liver dysfunction and subsequently administered 5-FU, the AUCs of 5-FU in the plasma and tumor tissue were increased by 2 and 1.3 times, respectively, as compared with non-treated mice. The Vmax (nmol\/mg protein\/min) of DHU (dihydrouracil dehydrogenase) in the liver homogenate from normal mice was 1.18 and found to be 0.70 in CCl4-treated mice. In conclusion, the pharmacokinetics of 5-FU were found to be dependent on the dose, infusion time, administration route and liver function, which seem to be correlated with the capacity of the catabolic enzyme, DHU.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26281222,"openaccessinfo":{"externalids":{"MAG":"2412272173","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: The purpose of this study to compare the efficiency of corticosteroid and platelet rich plasma (PRP) for the treatment of chronic plantar fasciitis. Materials and Methods: The present study was conducted in Department of Orthopaedics at Dr. D. Y. Patil Medical College and Hospital, Pimpri, Pune from June 2013 to September 2015. In this series, forty patients having chronic plantar fasciitis were treated with PRP and corticosteroid injection. The results were evaluated prospectively to compare the efficacy of both the procedures. One group of twenty patients received an injection of corticosteroid and the second group of twenty patients received an injection of PRP. Patients were selected if they fit into the inclusion criteria of the study after random selection. Results: Both groups initially performed well. The patients were followed up at 3, 6, and 12 months interval and were analyzed with the scoring systems (American Orthopedic Foot and Ankle Society [AOFAS], visual analog scale and Roles and Maudsley system). The average pretreatment AOFAS score at 3 months after treatment in the steroid group was 45 and improved to 82 and in the PRP group was 44 and improved to 90. However, the steroid group scores degraded with a sharp drop in the AOFAS rating to 74 at 6 months and 62 at 12 months after treatment. In stark contrast, the PRP group scores remained high with AOFAS scores of 87 at 6 month and 85 at 12 months after treatment. Conclusion: This study confirms the long-term superiority of PRP over corticosteroid injection for chronic planter fasciitis.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":80562321,"openaccessinfo":{"externalids":{"MAG":"2614441446","ACL":null,"DOI":"10.4103\/MJDRDYPU.MJDRDYPU_109_16","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"All children walk into our schools using ways they have learned to communicate and problem solve within their homes and communities. These \"ways of knowing\" are important, familiar, and valued because children have learned them at the knee and by the sides of those they care about the most. As educators, we need to value the \"ways of knowing\" or \"funds of knowledge\" (Gonzalez, Moll, & Amanti, 2005) that accompany all students to school. However, for English language learners (ELLs) or children who first language is not English, if we don't know about their communities and homes, we are teaching blind, so to speak. In this paper, we focus on one foundational area for early literacy development -- oral language as a window into ELL's cultural and linguistic backgrounds, and outline ways teachers can become familiar with their ELLs' \"ways of knowing.\" First, we discuss language as a phenomenon that evolves naturally and serves as the basis upon which literacy develops. Then we offer a number of suggestions for ways teachers can enhance language to benefit young children's literacy development in the preschool through 2nd grade period.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":252635962,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.56887\/galiteracy.50","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/galiteracyjournal.org\/index.php\/gjl\/article\/download\/50\/48","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This study evaluated the laboratory properties of asphalt binder and mixture modified with SPC(Sulfur Polymer Cement), which consists of sulfur as a main ingredient that is an industrial by-product made from refining process of crude oil and carbon-black as an additive. Four levels of SPC modifier ratios(0, 10, 30, 50%) were evaluated in the laboratory. Superpave(Superior Performing Asphalt Pavements) system was used to determine the PG(Performance Grade) and evaluate the property of SPC modified binder at the different temperatures. IDT(Indirect Tensile Test) was performed to evaluate the resistance of fatigue and low-temperature cracking at 10\u2103 and -10\u2103. Wheel-tracking test was also performed to evaluate the rutting-resistance of SPC modified asphalt mixtures. Test results showed that the more SPC modifier ratios, the better rutting-resistance and the more potential of low-temperature cracking resistance. However, SPC modifier did not show the effect on the fatigue cracking resistance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":138022640,"openaccessinfo":{"externalids":{"MAG":"2252771909","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The differentiation of F9 teratocarcinoma cells mimics the formation of a mouse embryonic tissue, the primitive endoderm. In vitro, small aggregates of F9 cells, termed embryoid bodies, differentiate in response to retinoic acid and develop a surface epithelium that is characterized by the production of alpha-fetoprotein. In the present study, cellular autofluorescence profiles obtained by fluorescence-activated embryoid bodies were composed of a single type of cell. In contrast, retinoic acid-induced embryoid bodies were composed of two cell types: a major population displaying autofluorescence levels similar to those of cells from undifferentiated embryoid bodies and a second population displaying higher autofluorescence. RNA analyses demonstrated that the transcription of alpha-fetoprotein was associated only with the more highly autofluorescent population, indicating that flow cytometry provides a novel mechanism for the separation of undifferentiated cells from differentiated endoderm cells in F9 embryoid bodies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32624473,"openaccessinfo":{"externalids":{"MAG":"2128080065","ACL":null,"DOI":"10.1002\/CYTO.990210206","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":". In recent years, the emergence of the new paradigm of compressive sensing (CS) has led to the development of innovative image\/signal processing and analysis tools that can be exploited to efficiently deal with serious challenges in pattern recognitions. This paper is concerned with the use of CS tools and dictionaries for face recognition, and in particular when dealing with uncontrolled conditions, e.g. faces captured at a distance in surveillance scenarios or in post-rioting forensic, whereby the images are severely degraded\/blurred and of low-resolution. We present the results of our recent investigations 1 into the construction of over-complete dictionaries that recover super-resolved face images from any input low-resolution degraded face image. These results demonstrate that non-adaptive image-independent implicitly designed dictionaries that guarantee the recovery of sparse signals achieve face recognition accuracy lev-els and yield significant recognition rates that are as good as if not better than those achieved by a recently proposed image-based learnt dictionaries. We shall also show that a variety of random dictionaries known to satisfy the Restricted Isometry Property (RIP), achieve similar accuracy rates, and thereby removing the need for training images. The high quality of the super-resolved images provides great potential for forensics and crime\/terrorism fighting.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":249315348,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Optical losses in c-plane (0001) GaN ridge waveguides, containing Mg-doped layers, were measured at 1064\u2009nm, using the Fabry-Perot method. The losses increase linearly with the modal content of the p-layer, indicating that the absorption in these waveguides is dominated by p-layer absorption. The p-layer absorption is strongly anisotropic with E\u22a5c losses 4 times higher than E\u2225c. The absorption is temperature independent between 10\u2009\u00b0C and 60\u2009\u00b0C, supporting the possibility that it is related to Mg-bound holes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":125630584,"openaccessinfo":{"externalids":{"MAG":"2735565766","ACL":null,"DOI":"10.1063\/1.4992103","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Transportation and land use planners generally agree that high traffic volumes are incompatible with a good residential street. Danger to pedestrians and bicyclists and emissions from traffic, such as high noise levels and poor air quality, are the obvious reasons. In addition, traffic is also a barrier to social interaction. In 1969, Donald Appleyard demonstrated that residents living on streets with high traffic volumes are likely to have fewer friends and acquaintances among their neighbors, socialize less in their neighborhood, and identify less with their street as home territory than residents of streets with lower traffic volumes. He found that residents on high volume streets withdraw from the physical environment of the street and do not care for it.1 After studying 21 residential streets with a wide range of traffic volumes, he concluded that the quality of residential street life starts to diminish when daily average traffic volumes exceed 8,000 cars.2 Evidence of the detrimental effects of traffic on neighborhood livability has been compelling, and transportation planners have made it their goal to divert high volume through-traffic from residential streets whenever possible. Many cities have implemented traffic management plans designed to tame traffic on residential streets. Such plans created protected neighborhoods by routing non-local traffic along arterial streets.3 According to these plans, through-traffic was directed to commercial areas or other non-residential land uses, but with limited success \u2014 most medium to high volume streets in existing cities are also residential streets. In the inner city neighborhoods of San Francisco where Appleyard carried out the initial study, more than 75 percent of all streets with 8,000 cars or more per day also serve predominantly residential land use. In communities with lower densities, the percentage of medium to high volume residential streets is even greater.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":129052459,"openaccessinfo":{"externalids":{"MAG":"2100168866","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Requirements engineering (RE) is an inherently piecemeal and dynamic process. Arrangement, correlation and integration of models presenting different views of the system are an important component of the requirements engineer's work. If manually performed, these operations are error-prone and time consuming and, thus, an integrated computer-aided environment for them would be very useful. In the paper, we present an extendable framework that provides a formalization and a generic integration pattern for scenario management. The framework is based on mathematical category theory machinery of algebraic operations with higher-order graphs. We demonstrate how the framework works by a (not entirely trivial) example of scenario integration. A distinctive feature of our integration pattern is an essential use of derived elements: for setting correspondences between views we augment view scenarios with derived executions. We show that this augmentation is essential for a proper integration: information explicitly specified in one view can be implicit in another view, where it is derived from the information considered basic in that view.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15871668,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Epilepsy is a major health problem, it being among the most common chronic neurologic pathologies. Its basic therapy is via anti-seizure drugs (ASDs), of which nearly two dozen are currently available for symptomatic treatment of epileptic seizures. But, notwithstanding the increasing ASD options, about one-third of epileptic patients remain drug-refractory, and this fraction did not diminish over decades. This paper reviews the subject of drug resistance in epilepsy (DRE), in view of exploring the prospect to overcome its persistence. The survey of various hypotheses about DRE origin and mechanisms notices that any of them alone does not fully account the DRE, their multitude deriving from the lack of solution to this bad medical need. The non-pharmacological (neurosurgical, brain stimulation, focal treatments and dietary) approaches of drug-intractable epilepsy are also surveyed, with the sober conclusion that, in a predictable future, the mainstay of epilepsy therapy will likely remain the drugs. The vast multiplicity of molecular changes associated with DRE suggests that its pharmacological resolution might arise only from integrative, systemic approaches, beyond the reductionist single-target paradigm that dominated the ASD discovery, in the last several decades. A conceivable lessening of DRE might be brought about by precision (personalized) medicine, assisted by complex systems biology description of individual epileptic pathology. In a longer run, the emergent network pharmacology might led to genuine innovative multi-potent antiepileptic drugs, able to treat distinct subpopulations of current refractory patients.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1,"unknown":2}},"corpusid":239717969,"openaccessinfo":{"externalids":{"MAG":"3193586206","ACL":null,"DOI":"10.18103\/mra.v9i8.2514","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/esmed.org\/MRA\/mra\/article\/download\/2514\/193545892","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION: Recurrent neonatal lower respiratory infections caused by endotracheal tubes (ETTs) may be related to the bacterial biofilm on them. OBJECTIVE: We aimed to investigate the microbial biofilm on the surface of ETTs removed from neonates with intubated ventilation to explore the relationship between ETT biofilm and the lower respiratory infections. METHODS: Twenty ETTs used in intubated neonates were examined for the presence of biofilm on their surface by scanning electron microscopy, and bacteria harvested from the surface of ETTs and the secretions of lower respiratory tracts were isolated, identified, and assessed for antimicrobial susceptibility. RESULTS: Scanning electron microscopy showed that the incidence of microbial colonization was 60% (12 of 20) when the use of tubes exceeded 2 days, biofilm formation was observed \u223c3 days after intubation, and its architecture became more mature and complex when the duration exceeded 3 days. There were 14 positive cultures from ETTs (70%, including 4 normal flora), in which 7 kinds of pathogens were isolated; in 13 cultures from the secretions of lower respiratory tract (65%, including 1 normal flora), 10 kinds of pathogens were isolated. Seven samples had the same pathogen both on the surface of ETTs and in the secretions of the lower respiratory tract, which accounted for 50 of the positive cultures from ETTs. The Gram-negative bacteria isolated from the surface of ETTs and the secretions of lower respiratory tract presented multiresistance to antibiotics. CONCLUSIONS: The ETT biofilm develops into a mature and complex form on the basis of the duration of tube use. There is a possible positive correlation between them. There is correlation between microbial biofilm formation on the surface of ETTs and lower respiratory tract infection in intubated neonates who are ventilated for a prolonged period of time. ETT biofilm could be a likely source of recurrent infection.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56825547,"openaccessinfo":{"externalids":{"MAG":"2054380483","ACL":null,"DOI":"10.1542\/PEDS.2007-2022OOOOO","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo test the hypothesis that discharge disposition for adolescents admitted to medical hospitals after attempting suicide varies as a function of hospital type and geographic region.\n\n\nDESIGN\nRetrospective cohort analysis.\n\n\nSETTING\nThe nationally representative Kids' Inpatient Database for 2000.\n\n\nPARTICIPANTS\nPatients aged 10 to 19 years with a diagnosis of suicide attempt or self-inflicted injury.Main Outcome Measure Likelihood of transfer to another facility vs discharge to home.\n\n\nRESULTS\nCare for 32 655 adolescents who attempted suicide was provided in adult hospitals (83% of hospitalizations), children's units in general hospitals (10%), and children's hospitals (4%). More than half (66%) of medical hospitalizations ended with discharge to home, 21% with transfer to a psychiatric, rehabilitation, or chronic care (P\/R\/C) facility, 10% with transfer to a skilled nursing facility, intermediate care facility, or short-term acute care hospital facility, and 2% with death or departure against medical advice. After adjustment for individual patient characteristics, children's units were 44% more likely than adult hospitals to transfer adolescent patients to a P\/R\/C facility (odds ratio [OR], 1.44; 95% confidence interval [CI], 1.07-1.94). Patients cared for outside the Northeast were significantly less likely to be transferred to a P\/R\/C facility (South: OR, 0.79; 95% CI, 0.65-0.97; Midwest: OR, 0.63; 95% CI, 0.49-0.80; West: OR, 0.29; 95% CI, 0.22-0.38).\n\n\nCONCLUSIONS\nMost adolescents admitted to a medical hospital after a suicide attempt are discharged to home, and the likelihood of transfer to another facility appears to be influenced by the geographic location of the admitting hospital and whether it caters to children.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":8623823,"openaccessinfo":{"externalids":{"MAG":"2073195348","ACL":null,"DOI":"10.1001\/ARCHPEDI.159.9.860","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The standard metabolic rate (SMR) of a number of species of Western Australian frogs is similar to that predicted for other anuran amphibians. The metabolic rate during activity is elevated 10-20 times above SMR, in close agreement with other studies of the energetics of amphibian activity. Species of two genera, Neobatrachus and Cyclorana, readily enter aestivation, which involves cessation of activity, formation of an epidermal cocoon, and depression of metabolic rate below SMR. The magnitude of metabolic depression varies between species from 70 to 80% (i.e. aestivation metabolic rate is 20-30% of SMR). The variation in magnitude of metabolic depression most likely reflects, in part, the difficulty of distinguishing the early stages of aestivation from the normal resting state. Both standard and aestivating metabolic rate are strongly mass-dependent, but the magnitude of metabolic depression is remarkably consistent in a number of different genera of frogs, salamanders and fish. The metabolic rate of aestivating amphibians is similar to that predicted for a unicellular organism of equivalent body mass, but is substantially lower than the metabolic rate of aestivating mammals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":84497882,"openaccessinfo":{"externalids":{"MAG":"2015282756","ACL":null,"DOI":"10.1071\/ZO9930467","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chiral amino acid analysis, especially the determination of trace levels of D-enantiomers, is currently gathering attention in a variety of research areas including the food\/clinical sciences. These D-amino acids had long been believed to be absent in the higher animals. However, by the advances of analytical technologies, some of the D-enantiomers are found in mammals including humans and increasingly recognized as novel physiologically-active substances and\/or biomarkers. For the determination of these D-amino acids and related compounds in real world samples, utilization of sensitive and selective methods is essential and multi-dimensional HPLC is one of the straightforward approaches. In the present review, two\/three-dimensional HPLC methods and biological\/medical applications focusing on our current studies are summarized.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":214197513,"openaccessinfo":{"externalids":{"MAG":"3008577616","ACL":null,"DOI":"10.15583\/jpchrom.2020.004","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/jpchrom\/41\/1\/41_2020.004\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Our aim is to show that it is impossible to find a bound for the power of the first fixed point of the aleph function.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42374860,"openaccessinfo":{"externalids":{"MAG":"1982768380","ACL":null,"DOI":"10.1142\/S0219061305000444","PubMedCentral":null,"ArXiv":"math\/0007021"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors compare the reliability of an enzyme method for diagnostics of chlamydial endocervicitis versus Clearview chlamydia test. The results suggest that the enzyme test may be applied with sufficient diagnostic reliability.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2321914,"openaccessinfo":{"externalids":{"MAG":"2755766525","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background : Posterior Urethral Valves (PUVs) is the commonest cause of bladder outlet obstruction in male infants and children. Vesicostomy is a temporary procedure to relieve the obstruction and save the kidneys from a progressive failure. Objectives : The primary objective of this study was to evaluate the benefits of vesicostomy in the initial management of children with posterior urethral valves (PUVs) in urology units with no infant endoscopes. The secondary objectives were to determine the effect of vesicostomy on improving or resolving hydronephrosis and stabilizing or improving renal function. Study Design : A retrospective hospital-based study. Setting : The study was conducted in the department of urology of Kilimanjaro Christian Medical Centre (KCMC), a tertiary hospital located in Moshi, Tanzania. Methods : Children who underwent vesicostomy between September 1998 and January 2012 were identified from theatre operation books. Patients' details including age, clinical presentation, serum creatinine, and imaging study (abdominal ultrasound and \/ or Micturating CystourethroGram) findings at presentation were extracted from the files of patients. The same variables were again documented in line with the objectives of the study with a three month postvesicostomy reference for comparison. Results : Forty-three patients had vesicostomy done in the period of study. The age ranged from 4 days to 15 months with a median of 6 months and mean \u00b1 standard deviation of 9.6 \u00b113.2months. The number of patients with severe hydronephrosis dropped from 26 (60.5%) to 17 (58.6%) three months after vesicostomy. This statistically insignificant change remained largely unchanged for the rest of the follow up. There was a significant decrease in serum creatinine three months after vesicostomy with a mean difference of 113.32umol\/l (P < 0.001). Conclusion : The study results showed that vesicostomy is reno-protective. Centres in the developing world without infant endoscopic equipments for primary ablation of valves should be encouraged to perform temporary vesicostomy. Key words : Posterior urethral valves, vesicostomy, electro- fulguration, renal failure.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":73188317,"openaccessinfo":{"externalids":{"MAG":"2104680043","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives REM sleep behavior disorder (RBD) is associated with cognitive dysfunctions and is a risk factor for development of mild cognitive impairment and dementia. However, it is unknown whether RBD is associated with faster cognitive decline in already established dementia. The main goal of this study was to determine if patients with mild dementia with and without RBD differ in progression rate and in specific neuropsychological measures over 4-year follow-up. Methods This longitudinal, prospective study based on data from the DemVest study compares neuropsychological measures in a mild dementia cohort. A diagnosis of probable RBD (pRBD) was made based on the Mayo Sleep Questionnaire. Neuropsychological domains were assessed by Mini Mental State Examination, total score and figure copying, California Verbal Learning Test-II, Visual Object and Space Perception Cube and Silhouettes, Boston Naming Test, Stroop test, Verbal Category Fluency, Trail Making Test A and B. Results Among the 246 subjects, 47 (19.1%) had pRBD at the baseline, and pRBD group was younger and with male predominance. During 4-year follow-up, we did not observe any significant differences in the rate of decline in neuropsychological measures. Patients with pRBD performed generally poorer in visuoconstructional, visuoperceptual, and executive\/attention tests in comparison to RBD negative. Conclusion We did not find any significant differences in progression rate of neurocognitive outcomes between dementia patients with and without RBD.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":21544755,"openaccessinfo":{"externalids":{"MAG":"2743881405","ACL":null,"DOI":"10.3389\/fneur.2017.00375","PubMedCentral":"5545761","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2017.00375\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In an era when knowledge is considered the most important factor in creating competitive advantages in organizations, it is especially important to pay attention to knowledge management (KM). Therefore, in order for the organization to be successful and have a better performance in this area, key success factors of knowledge management should be emphasized. It is a highly difficult task to bring about change in an organization and enable an organization to utilize all of the forms and capabilities of knowledge management using the available resources in order to obtain its goals regarding its circumstances and binding commitments. Assessment and evaluation depend upon the concepts of knowledge. One of the keys to success is to achieve high quality products. There are two common approaches in all organizations for achieving key success factors, one of them is the business process and the other is human resources process. Both of these processes are crucial for building major organizations and companies, but human resources should be emphasized here. Here, I start with providing definitions for management, knowledge, different types of knowledge, and knowledge management systems and then I will discuss about what knowledge management is and whether or not the knowledge of management preferred to knowledge management.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":167361259,"openaccessinfo":{"externalids":{"MAG":"2188883905","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The complete genome of hepatitis E virus (HEV) from laboratory ferrets imported from the United States was identified. This virus shared only 82.4%\u201382.5% nt sequence identities with strains from the Netherlands, which indicated that the ferret HEV genome is genetically diverse. Some laboratory ferrets were contaminated with HEV.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28225808,"openaccessinfo":{"externalids":{"MAG":"2089476606","ACL":null,"DOI":"10.3201\/eid2004.131815","PubMedCentral":"3966362","ArXiv":null},"license":"CCBY","url":"https:\/\/wwwnc.cdc.gov\/eid\/article\/20\/4\/pdfs\/13-1815.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The term of collaborative filtering [Goldberg, 2000] denotes techniques using the known tastes of a group of users to predict the unknown preference of a new user. The distinctive feature of current collaborative filtering processes is to be centralized. The scientific problems have consisted in finding a way to distribute calculus, in order to provide scale for several ten thousands of people, or then to preserve anonymity of users (personal data remain on client side). The impact of a model combining several existing methods to share out tasks between the server and users terminals is examined in this article. A partnership with the company ASTRA allows to turn to their database and to carry out life-sized tests in order to verify efficiency of proposed solutions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":114193854,"openaccessinfo":{"externalids":{"MAG":"2620571403","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study links theories concerning methods that firms use to acquire technology with theories concerning types of technological change. We place particular emphasis on interorganizational relationships. We predict that firms will often acquire know-how needed for encompassing technological change through equity-based arrangements with other organizations, complementary technological changes through nonequity interorganizational arrangements, and incremental changes through internal R&D. Our theory draws on perspectives that emphasize the need to develop new competencies within a business organization and to protect the value of existing competencies. Our empirical analysis examines methods of technology acquisition that firms have used in the commercialization of medical lithotripters, which are devices that fragment stones in the kidney and gall bladder. The analysis contributes to a better understanding of how technology acquisition methods vary with the manner in which technological change relates to a firm's existing capabilities. The study also helps develop our understanding of the evolutionary processes by which capabilities diffuse through an industry.\u00a9 1998 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":7675585,"openaccessinfo":{"externalids":{"MAG":"2018706965","ACL":null,"DOI":"10.1002\/(SICI)1097-0266(1998110)19:11<1063::AID-SMJ993>3.0.CO;2-W","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A real-time algorithm for estimating the subsample delay between two noisy sinusoidal signals is presented. The new technique is based on the recently proposed discrete-time quadrature delay estimator (QDE). The algorithm uses all of the in-phase and quadrature-phase components of the received signals to produce a bias-free estimate of the delay between the input signals. The technique directly updates the delay error estimate, which is in turn used to adapt the coefficients of a simple fractional delay filter (FDF). The algorithm is insensitive to variations in the amplitudes of the input signals, and does not require an accurate estimate of the frequency of the input sinusoids. The technique is simple to implement and has a significantly reduced complexity compared to other adaptive techniques. Simulations show that in the presence of system noise, the new estimator outperforms conventional fractional delay filter based estimators.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1104521,"openaccessinfo":{"externalids":{"MAG":"1632431142","ACL":null,"DOI":"10.1109\/ISCAS.2004.1328747","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND PURPOSE: The time course of changes in posterior fossa morphology, quality of life, and neurologic function of patients with Chiari I malformation after craniocervical decompression requires further elaboration. To better understand the pace of these changes, we longitudinally studied patients with Chiari I malformation, with or without syringomyelia, before and after the operation for up to 5years. MATERIALS AND METHODS: Thirty-eight symptomatic adult patients (35 women, 3 men) diagnosed with Chiari I malformation only ( n \u00bc 15) or Chiari I malformation and syringomyelia ( n \u00bc 23) and without previous Chiari I malformation surgery were enrolled in a clinical study. Patients underwent outpatient study visits and MR imaging at 7 time points (ie, initial [before the operation], 3 months, 1 year, 2 years, 3 years, 4 years, and 5 years) during 5 years. The surgical procedure for all patients was suboccipital craniectomy, C1 laminectomy, and autologous duraplasty. RESULTS: Morphometric measurements demonstrated an enlargement of the CSF areas posterior to the cerebellar tonsils after the operation, which remained largely stable through the following years. There was a decrease in pain and improved quality of life after the operation, which remained steady during the following years. Reduction in pain and improved quality of life correlated with CSF area morphometrics. CONCLUSIONS: Most changes in MR imaging morphometrics and quality of life measures occurred within the fi rst year after the operation. A 1-year follow-up period after Chiari I malformation surgery is usually suf fi cient for evaluating surgical ef fi cacy and postoperative MR imaging changes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264545604,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study investigates the implementation and follow-up of the environmental and social impact assessment (ESIA) in Meta Abo Brewery in Ethiopia. Specifically, it aims to assess the implementation mechanism and status of ESIA monitoring and evaluation, the adequacy of the legal and administrative framework for ESIA implementation and follow-up, and the perception of residents towards the ESIA implementation and follow-up by the proponent. A mixed research approach was employed to collect and analyze both qualitative and quantitative data. Thematic and descriptive data analysis was used to analyze data collected through key informant interviews (KII), focus group discussion (FGD), closed-ended questions, and document review. Data were obtained from 11 purposely selected interviewees and 6 FGD participants, as well as 175 randomly selected respondents. This study found the practical implementation mechanism of ESIA monitoring and evaluation as well as weak ESIA monitoring and evaluation status through the case study. The main causes of this weak ESIA system are weak implementation of ESIA monitoring and evaluation by the regulatory body and proponent, weak cooperation among regulatory body and proponent, weak institutional capacity, and weak managerial commitments. The study also indicated a lack of adequate legal and administrative frameworks and the absence of regular revision of relevant legislation. Additionally, the study identified that the proponent has some weaknesses in the ESIA implementation and follow-up. The findings regarding the legal and administrative framework can be developed to guide the formulation and amendment of the ESIA legal and administrative framework not only for Ethiopia, but other developing countries as well. Moreover, the findings of this study can be a groundwork for future studies to fill the gap by understanding the social-cultural barrier and finding appropriate strategies to enhance the ESIA system in developing countries.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":245484499,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/su14010133","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2071-1050\/14\/1\/133\/pdf?version=1640267561","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Robots are still limited to controlled conditions, that the robot designer knows with enough details to endow the robot with the appropriate models or behaviors. Learning algorithms add some flexibility with the ability to discover the appropriate behavior given either some demonstrations or a reward to guide its exploration with a reinforcement learning algorithm. Reinforcement learning algorithms rely on the definition of state and action spaces that define reachable behaviors. Their adaptation capability critically depends on the representations of these spaces: small and discrete spaces result in fast learning while large and continuous spaces are challenging and either require a long training period or prevent the robot from converging to an appropriate behavior. Beside the operational cycle of policy execution and the learning cycle, which works at a slower time scale to acquire new policies, we introduce the redescription cycle, a third cycle working at an even slower time scale to generate or adapt the required representations to the robot, its environment and the task. We introduce the challenges raised by this cycle and we present DREAM (Deferred Restructuring of Experience in Autonomous Machines), a developmental cognitive architecture to bootstrap this redescription process stage by stage, build new state representations with appropriate motivations, and transfer the acquired knowledge across domains or tasks or even across robots. We describe results obtained so far with this approach and end up with a discussion of the questions it raises in Neuroscience.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":218613677,"openaccessinfo":{"externalids":{"MAG":"3024138969","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2005.06223"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"size and computing power for decades, making great strides in the process. One set of tools driving the next generation of smaller, more powerful electronics are high-density, high-layer count circuits. Liquid Crystal Polymer is emerging as a promising material for high-density circuits, particularly for high-frequency applications. This paper describes the process for manufacturing high-density, high-layer count circuits In LCP and discusses some applications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":221317365,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary Introduction: Sarcoidosis is a systemic, chronic, granulomatous disease of unknown cause. Pancreatic affection is rare and even more rare is the association among sarcoidosis, acute pancreatitis and diabetes mellitus. This is the first case reported in Mexico. Case report: Male 29 years. Sarcoidosis is diagnosed from the patient age of 20 years, with intermittent episodes affecting articulate, ophthalmic, cutaneous, lung and central nervous system. At 22 years of age the patient was diagnostic with diabetes mellitus. He was admitted with severe acute pancreatitis, that causes him to die. Discussion: Diabetes mellitus is due to sarcoidotic infiltration of pancreas. Acute pancreatitis has been related with inflammatory or secondary process to frequent presence of hypercalcemia in the sarcoidosis. Diagnosis is not easy. This type of pancreatitis responds to treatment with steroids.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":70442283,"openaccessinfo":{"externalids":{"MAG":"1577922577","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although tree nutrition has not been the primary focus of large climate change experiments on trees, we are beginning to understand its links to elevated atmospheric CO\u2082 and temperature changes. This review focuses on the major nutrients, namely N and P, and deals with the effects of climate change on the processes that alter their cycling and availability. Current knowledge regarding biotic and abiotic agents of weathering, mobilization and immobilization of these elements will be discussed. To date, controlled environment studies have identified possible effects of climate change on tree nutrition. Only some of these findings, however, were verified in ecosystem scale experiments. Moreover, to be able to predict future effects of climate change on tree nutrition at this scale, we need to progress from studying effects of single factors to analysing interactions between factors such as elevated CO\u2082, temperature or water availability.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17093814,"openaccessinfo":{"externalids":{"MAG":"2113955716","ACL":null,"DOI":"10.1093\/treephys\/tpq040","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/treephys\/article-pdf\/30\/9\/1209\/4626128\/tpq040.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Protecting solar system bodies from biological contamination is of critical importance to the future success of NASA's science and exploration missions, as is protecting the Earth from the importation of life from elsewhere, if it exists. As the planned array of missions grows, the details of the data that drive future planetary protection concerns will be increasingly important. Not all locations on a solar system body will warrant the same contamination control requirements. For example, the picture of Mars that has emerged from the Mars global surveyor and Odyssey missions stands in marked contrast from that portrayed shortly after the Viking missions of the mid-1970s. The water-ice abundance at both the polar caps, and as it is inferred from hydrogen abundance in lower latitudes, is particularly intriguing, adding to a heightened consideration that Mars might support indigenous life - or could be contaminated by life brought from Earth. Elsewhere in the solar system the potential for a liquid-water ocean within Europa, and for liquid water under the surface of other icy bodies - including Saturn's moon Titan - can highlight the problems involved with possible biological contamination that may be carried by future missions. A particular challenge are missions carrying perennial heat sources of high capacity and longevity (e.g., radioactive power sources) which could, by nonnominal landings or other mission operations, be introduced to close contact with water ice -potentially forming Earthlike environments that could accommodate the growth of contaminant organisms. Sample return missions from bodies that may harbor indigenous life will also require carefully contained Earth-return phases, biohazard testing, and initial science studies to be performed in a safe receiving facility. Translating planetary protection requirements into affordable and achievable engineering solutions at both the mission and subsystem level will require that a wide array of tools be accessible to mission designers, as well as an intimate understanding of potential sources of contamination and the accessibility of likely habitats on other worlds. Current priorities for technology development in view of the requirements for the next decade missions are discussed and developed in this paper.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":25878213,"openaccessinfo":{"externalids":{"MAG":"2133161790","ACL":null,"DOI":"10.1109\/AERO.2005.1559318","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the analysis of two surveys, one academic and one industrial. The goal was to provide research perspectives in the field of change management for industrial systems. This communication is the result of multi-disciplinary study (ADESI project) launched by the National Centre of Scientific Research, CNRS. The \"raison d'etre\" of this work, is to answer the strong need to coordinate both academic and industrial communities as well as the necessity of multi-disciplinary approaches for decision-aids applied to change management.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":111044364,"openaccessinfo":{"externalids":{"MAG":"2044907584","ACL":null,"DOI":"10.3182\/20060522-3-FR-2904.00033","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work presents an unsupervised approach for improving WordNet that builds upon recent advances in document and sense representation via distributional semantics. We apply our methods to construct Wordnets in French and Russian, languages which both lack good manual constructions.1 These are evaluated on two new 600-word test sets for word-to-synset matching and found to improve greatly upon synset recall, outperforming the best automated Wordnets in F-score. Our methods require very few linguistic resources, thus being applicable for Wordnet construction in low-resources languages, and may further be applied to sense clustering and other Wordnet improvements.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":12124859,"openaccessinfo":{"externalids":{"MAG":"2611056830","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1705.00217"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To understand the ecological role of cyanophage and its effect on nutrients cycling in the coastal marine environment, it is critical to understand cyanophage infectivity and the interactions that occur between the phage and its host, marine cyanobacterial picoplankton (Synechococcus sp.). We previously isolated a new virulent cyanophage (strain S-KM1), and here have investigated its seasonal infectivity of cyanophage, phycoerythrin-rich Synechococcus sp. (strain KFM001) in Kagoshima Bay. We found that the phage titers ranged from undetectable to 7.5\u00d7103\/ml in autumn, and began to increase about one week after the onset of the Synechococcus autumn bloom. During the autumn months, the phage numbers oscillated in a fashion that mirrored levels of host abundance, showing a lag of about one week. We calculated that from 0.0055% to 2.1% of the host population per day was lysed by the phage during a Synechococcus bloom in autumn. This suggests that lytic phages have a noticeable effect on regulating the densities of marine Synechococcus populations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":84292102,"openaccessinfo":{"externalids":{"MAG":"2043815325","ACL":null,"DOI":"10.1264\/JSME2.18.10","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Wireless mesh networks (WMNs) are wireless multihop networks comprised of mesh routers, which relay traffic on behalf of clients and other nodes. Using the standard IEEE 802.11 distributed coordination function (DCF) as MAC layer, a node needs to contend for the medium each time it wants to transmit a packet. This creates high overhead in particular for small packets and leads to poor performance for real-time applications such as Voice over IP (VoIP) or online gaming. Burst packet transmission can increase the efficiency. For example, with the Transmission Opportunity limit (TXOPlimit) in IEEE 802.11e, a station may transfer several packets without contending for the channel in between. Similarly, IP packet aggregation combines several IP packets together and sends them as one MAC Service Data Unit. Originally, both schemes have been developed for singlehop networks only. Thus the impact on WMNs is unclear if the packets need to contend over multiple hops. In this paper, we use measurements from a 9-node WMN testbed to compare TXOPs and IP packet aggregation for VoIP in terms of fairness, network capacity and quality of user experience. We show that for low networks loads, both TXOPs and IP packet aggregation increase the VoIP quality compared to IEEE 802.11 DCF. However, in highly loaded networks IP packet aggregation outperforms the other schemes.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":996599,"openaccessinfo":{"externalids":{"MAG":"2109048960","ACL":null,"DOI":"10.1109\/GLOCOM.2010.5684219","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have described a mobile miniature-gamma-camera system for use in electrical trauma units and have presented images and imaging characteristics of a prototype system. The system has as its principal component a miniature gamma camera based on a PSPMT. The camera is 92 mm x 92 mm x 190 mm in size, weighs 5 kg, has a 48 mm x 48 mm field of view, and has an intrinsic resolution of approximately 3 mm FWHM and 6 mm FWTM. It is expected that devices of this type will be useful as imaging tools in electrical trauma units and laboratories where imaging studies regarding uptake mechanisms of radiopharmaceuticals for assessing tissue viability are carried out.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21014835,"openaccessinfo":{"externalids":{"MAG":"2156847531","ACL":null,"DOI":"10.1111\/j.1749-6632.1994.tb30447.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The theoretical formulation of second-order random waves in deep and finite water is reviewed. In particular, the increased nonlinear interactions with decreasing depth are addressed, including both the sum-frequency as well as the slowly varying difference-frequency components. Depth-defined limitations in the valid range for random waves are suggested based on the Ursell number. Numerical time series realizations at various depths and for two sea states are obtained by an efficient bifrequency summation procedure. Resulting time series show moderate average second-order energy contents, except for the steep sea state Hs = 15m, Tp = 14s in depths of 30m and 20m which are outside the suggested valid second-order range. The two largest wave events from the simulations are studied in particular for the different depths. Nonlinear interactions increase significantly with decreasing depth. Still, within the valid range, extreme second-order crests and peak particle velocities are only moderately increased with decreasing depth, while the negative peaks increase significantly. This is because the difference-frequency component almost compensates for the sum-frequency part at crests, while it is opposite at troughs. Maximum slopes, however, are clearly increased in shallow water, eventually leading to increased breaking (which is beyond second order of course). Velocity profiles under the crests are also shown, confirming the findings from the elevation.Copyright \u00a9 2011 by ASME","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":129746687,"openaccessinfo":{"externalids":{"MAG":"1963772692","ACL":null,"DOI":"10.1115\/OMAE2011-50219","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Do workers benefit from proximity to other workers with similar skill sets? This question dates back at least to Alfred Marshall. We use occupation groups to proxy skill sets and show that the answer likely depends on geographical levels, as well on regional hierarchy. Using longitudinal Swedish data, we document robust evidence consistent with highly localized spillovers at the level of sub-city districts between individuals in similar occupations. We further demonstrate less distance-sensitive benefits of working in districts and regions, characterized by high overall density (of employees in other occupations). We find no evidence of benefits from overall density outside Sweden's three main metropolitan areas.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":226413298,"openaccessinfo":{"externalids":{"MAG":"3192405037","ACL":null,"DOI":"10.1080\/00343404.2021.1954611","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00343404.2021.1954611?needAccess=true","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The trend toward greater provision of payments services by nonbank providers raises a question for regulators: What if these nonbank institutions suffer unfavorable balances or experience a run? The authors of this article look to the Panic of 1907 as an example of how private market participants, in the absence of government institutions, react to a crisis in their industry. They suggest that New York's and Chicago's contrasting experiences during the panic may provide useful lessons for both regulators and market participants. ; The article compares responses to the panic by bank intermediaries in the two cities through clearinghouses. The apparent isolation of trusts from the New York Clearinghouse left the clearinghouse with inadequate knowledge of their condition and hindered prompt action. In Chicago, the clearinghouse had timely information on most intermediaries in the city, including the trusts, and therefore was positioned to react quickly. ; The distinct nature of the Panic of 1907 and the differences between private market regulation through clearinghouses and the current framework of public regulation limit recommendations for today's financial world. Nonetheless, the historical experience provides a precedent for the development and growth of payments services offered by nonbank providers, which should not be ignored as key players in the payments system. The key lesson from history is that such ignorance can be expensive.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55495891,"openaccessinfo":{"externalids":{"MAG":"1507101110","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For the purpose of writing this paper, we have been to choose this subject as it is a core part of the pharmaceutical companies' business strategy for promoting medicines. Regarding the importance of the research theme and the business environment, it is crucial that anyone connected to this business should realize the importance of organization, details, good deployment and impact of each event. In this respect, marketing can be seen as a true system of economic activities related to the programming of products and services that have the role of satisfying the requirements of current and potential consumers considerably, but is also linked to prices, promotion and distribution products or services. Taking into consideration the importance that marketing has within the pharmaceutical field and the huge budgets that medical and pharmaceutical companies spend for the events organized in this domain, I consider that a company which is able to have a new approach and a new vision for the organization of events and sharing medical education to doctors and medical information to patients will have a big success.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210125558,"openaccessinfo":{"externalids":{"MAG":"2994735391","ACL":null,"DOI":"10.26458\/1944","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"http:\/\/anale.spiruharet.ro\/index.php\/economics\/article\/download\/1944\/pdf_1","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective: Motor experience plays a central role in cognitive development. Assistive technologies can thus provide augmentative manipulation for children with motor disabilities. This paper explores the use of robots to this end. Method: A revision of studies conducted with typically\u2010developing children and children with disabilities regarding the use of robots is presented. This revision provides a description of the cognitive skills required and revealed by the child when using a robot. Opportunities for participation and exploration were identified and further research is discussed. Results: Robots provide insight into the cognitive skills of children with motor disabilities. Robots also provide means for independent exploration and participation in learning and play activities. Integration of augmentative manipulation and communication increases interest and participation of children with disabilities. Conclusion: Children with disabilities can use augmentative manipulation systems to independently explore and interact with their environment. Children can use robots as tools providing them with opportunities to reveal and further develop their cognitive skills. Alternative access methods can increase access for children with severe motor disabilities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":40924481,"openaccessinfo":{"externalids":{"MAG":"2053899143","ACL":null,"DOI":"10.3109\/17518423.2011.635609","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Purpose Breast cancer (BC) is one of the most common malignancies globally, and millions of women worldwide are diagnosed with BC every year. Up to 70% of BC patients are estrogen receptor (ER)-positive. Numerous studies have shown that tamoxifen has a significant therapeutic effect on both primary and metastatic ER-positive BC patients. Although tamoxifen is currently one of the most successful therapeutic agents for BC, a significant proportion of patients will eventually become resistant to tamoxifen, leading to tumor recurrence and metastasis. Knowledge about the development of tamoxifen resistance in BC patients is still limited. Methods We applied a loss-and-gain method to study the biological functional role of cell division cycle associated 8 (CDCA8) in tamoxifen resistance in BC cells. Results We found that CDCA8 was significantly elevated in tamoxifen-resistant BC cells. Knockdown of CDCA8 expression significantly inhibited the proliferation of tamoxifen-resistant BC cells and reduced their resistance to tamoxifen. In contrast, overexpression of CDCA8 promoted the growth of tamoxifen-sensitive BC cells and induced their resistance to tamoxifen. Conclusion In this study, we reported that CDCA8 is a key regulator of tamoxifen resistance in BC, suggesting that CDCA8 may serve as a potential therapeutic target for BC treatment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":195803982,"openaccessinfo":{"externalids":{"MAG":"2952660336","ACL":null,"DOI":"10.4048\/jbc.2019.22.e29","PubMedCentral":"6597414","ArXiv":null},"license":"CCBYNC","url":"http:\/\/ejbc.kr\/Synapse\/Data\/PDFData\/0096JBC\/jbc-22-237.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The Eosinophil Leucocytes. By R. K. Archer, MA, PhD, MRCVS. Price, $7.95. Pp 205, with 70 illustrations. F. A. Davis Company, 1914-1916 Cherry St, Philadelphia 19103, 1963. The first of these two books is a compilation of papers presented by a study group under the sponsorship of the Ciba Foundation in March, 1961. The papers deal with the functional activities of the white cell, studied both in vivo, and in vitro. Though reference is made to nonhuman material, most of the reports cover experiments in man and with the white cells of man. Each of the papers is by an expert in the field and presents both a review of the subject and the author's own contribution. The papers are documented with references and further enriched by a transcription of the group's discussion. The second book is quite different in format and origin. It summarizes the author's experiments with the","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":71969057,"openaccessinfo":{"externalids":{"MAG":"2019724090","ACL":null,"DOI":"10.1001\/ARCHINTE.1964.03860100159046","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: To study whether metacognition is a prerequisite for coping at the tactical level of driving. Research design: A consecutive series of 30 drivers with acquired brain injury were assessed concerning cognitive functions and driving performance. In addition the drivers assessed their driving performance through self-rating. Results: On average the drivers had cognitive impairments compared to a healthy reference group. The group that passed the driving test and the group that failed the driving test did not differ in terms of cognitive functions. Neither did they differ in their self-ratings of driving performance. However, the group that failed the driving test significantly over-estimated their performances as compared to the assessments made by the professional driving inspector, while the group that passed the test made more accurate self-ratings. Conclusions: One interpretation of these results is that the group that made a more realistic evaluation of their driving performance were more aware of their cognitive capacity compared to those who failed the driving test. They seemed to have a better ability to adjust their driving behaviour at a tactical level. Thus, the subject's metacognition, awareness of his\/her own cognitive capacity, is important for coping with cognitive impairments at tactical driving.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":46020384,"openaccessinfo":{"externalids":{"MAG":"2146747988","ACL":null,"DOI":"10.1080\/02699050701651660","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The total downward shear deflection of the amidship frame and the total rotation of the end frames in the ship are the sum of the respective deflections of all the frame sections on one side of amidships.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33197460,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Currently, HPC storage systems still use hard disk drive (HDD) as their dominant storage device. Solid state drive (SSD) is widely deployed as the buffer to HDDs. Burst buffer has also been proposed to manage the SSD buffering of bursty write requests. Although burst buffer can improve I\/O performance in many cases, we find that it has some limitations such as requiring large SSD capacity and harmonious overlapping between computation phase and data flushing phase. In this article, we propose a scheme, called SSDUP+.1 SSDUP+ aims to improve the burst buffer by addressing the above limitations. First, to reduce the demand for the SSD capacity, we develop a novel method to detect and quantify the data randomness in the write traffic. Further, an adaptive algorithm is proposed to classify the random writes dynamically. By doing so, much less SSD capacity is required to achieve the similar performance as other burst buffer schemes. Next, to overcome the difficulty of perfectly overlapping the computation phase and the flushing phase, we propose a pipeline mechanism for the SSD buffer, in which data buffering and flushing are performed in pipeline. In addition, to improve the I\/O throughput, we adopt a traffic-aware flushing strategy to reduce the I\/O interference in HDD. Finally, to further improve the performance of buffering random writes in SSD, SSDUP+ transforms the random writes to sequential writes in SSD by storing the data with a log structure. Further, SSDUP+ uses the AVL tree structure to store the sequence information of the data. We have implemented a prototype of SSDUP+ based on OrangeFS and conducted extensive experiments. The experimental results show that our proposed SSDUP+ can save an average of 50% SSD space while delivering almost the same performance as other common burst buffer schemes. In addition, SSDUP+ can save about 20% SSD space compared with the previous version of this work, SSDUP, while achieving 20\u201330% higher I\/O throughput than SSDUP.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":62910948,"openaccessinfo":{"externalids":{"MAG":"3010437116","ACL":null,"DOI":"10.1145\/3377705","PubMedCentral":null,"ArXiv":"1902.05746"},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3377705","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":": Heart disease is the one of the major disease and many human beings suffered without any symptoms. In healthcare, especially in finding of heart disease in particular time plays a crucial role in cardiology area. In this paper, we proposed an effective and perfect system to predict heart disease system based on machine learning systems. This system is organized by using various classification algorithms such as LR,KNN,SVM,DT,NB and RF. The proposed algorithmic technique also solve the problem of feature selection and increase the accuracy of classification. In addition with that, the proposed algorithmic technique could use non-invasive clinical data for the heart Disease diagnosis and assessing its severity. The implementation of novel hybrid method helps to improve the accuracy of the EDA diagnosis. The proposed novel hybrid method result shows high accuracy of data is compared to previously proposed techniques. In addition to that, the proposed system is easily be adapted with the existing technology.in this proposed system technology more the 300 instance are collected and the results are compared with existing technology. The results prove that it has more accuracy and it can be easily implemented to identify CAD disease in healthcare field.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":248095882,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Graphene oxide (GO) monolayer sheets, transferred onto Si by the Langmuir\u2013Blodgett technique, were subjected to ammonia plasma treatment at room temperature with the objective of simultaneous reduction and doping. Scanning electron microscopy and atomic force microscopy studies show that plasma treatment at a relatively low power (\u223c10 W) for up to 15 min does not affect the morphological stability and monolayer character of GO sheets. X-ray photoelectron spectroscopy has been used to study de-oxygenation of GO monolayers and the incorporation of nitrogen in graphitic-N, pyrrolic-N and pyridinic-N forms due to the plasma treatment. The corresponding changes in the valence band electronic structure, density of states at the Fermi level and work function have been investigated by ultraviolet photoelectron spectroscopy. These studies, supported by Raman spectroscopy and electrical conductivity measurements, have shown that a short duration plasma treatment of up to 5 min results in an increase of sp2-C content along with a substantial incorporation of the graphitic-N form, leading to the formation of n-type reduced GO. Prolonged plasma treatment for longer durations results in a decrease of electrical conductivity, which is accompanied by a substantial decrease of sp2-C and an increase in defects and disorder, primarily attributed to the increase in pyridinic-N content.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24622209,"openaccessinfo":{"externalids":{"MAG":"1979293267","ACL":null,"DOI":"10.1088\/0957-4484\/24\/35\/355704","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Marriage in Islam is categorized as part of the Prophet's tradition; however, it is also rooted in human creation. Human marriage is a sample of general coupling in nature; nevertheless, unlike other creatures whose mating is instinctive, human marriage is performed based on his will. Different functions of marriage can be explained by considering coupling. One of the main functions of coupling is providing a suitable response to sexual desire. And this will improve sexual health. Religion aims at responding to the sexual desire within marriage in order to form a family with the purpose of reproduction, not just taking pleasure. In religious teachings, controlling sexual desire is mentioned in the form and context of patience when caught in sinful situations. Patience is the recommended mechanism for controlling lust and sexual desire. Patience is a cognitive and internal skill used for controlling lust free from external interference. Indeed, this can be called self-control. According to religious teachings, patience is not an inactive concept, but rather a dynamic response the intensity of which is tightly related to one's level of knowledge, cognition and awareness. This article aims at explaining the cognitive features of patience, as the most significant recommendation to control the sexual desire. In fact, in this way, sexual desire is not suppressed and its arousal does not cause corruption within man's social relations. And consequently, his health in various dimensions is guaranteed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":151654744,"openaccessinfo":{"externalids":{"MAG":"2503558161","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Faradey established the law of induction, carrying out experiments on the solenoids, including turning off in them current, or moving with respect to the solenoids the turns of the wire, to which was connected the galvanometer. Its point of view, which is considered accurate and today, was reduced to the fact that with the connection to the solenoid of the dc power supply U , then current in all its turns increases according to the linear law of Ut I L = , (1)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55287233,"openaccessinfo":{"externalids":{"MAG":"255865069","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Accurate ground-based remotely sensed microphysical and optical properties of liquid water clouds are essential references to validate satellite-observed cloud properties and to improve cloud parameterizations in weather and climate models. This requires the evaluation of algorithms for retrieval of cloud microphysical and optical properties using ground-based remote sensing observations, because there are large differences between the cloud property retrievals of various algorithms due to the differences in the applied retrieval theories, assumptions, retrieval inputs and constraints. This thesis focuses on three commonly used vertical cloud models for the parameterization of the in-cloud vertical structure in cloud property retrieval schemes. The objective is to explore the impact of the vertical cloud models on the computations of microphysical and optical properties of liquid water clouds and to evaluate their uncertainties. This information can help to improve current liquid water cloud property retrieval schemes and to increase the accuracy of the obtained cloud physical properties. A comparison of three algorithms with different vertical cloud models for the retrieval of liquid water cloud microphysical and optical properties is performed. In the first algorithm, the vertical structure of the cloud is parameterized as being vertically homogeneous (Vertically Uniform, VU). In the second algorithm, the used vertical cloud model originates from an adiabatic model (Scaled Adiabatic Stratified, SAS) and the third algorithm relies on a vertical model, which considers the impact of cloud top entrainment mixing processes on the cloud microphysical properties (Homogenous-Mixing, HM). All three algorithms use observations of the cloud radar reflectivity, the microwave radiometer obtained liquid water path (LWP) and the cloud geometrical thickness from lidar and cloud radar. They require a priori assumptions on the cloud droplet size distribution (DSD). Hence, the gamma function is used to parametrize the DSDs and possible values for the gamma DSD shape parameter are evaluated from reanalyzed in-situ observations. All three algorithms investigated here retrieve vertical profiles of the liquid water content (LWC), the droplet concentration, the effective radius, the visible optical extinction and the visible optical depth. The differences between the cloud property retrievals of each algorithm are explained on the basis of remote sensing observations that appear to be typical for low-level water clouds. The results of the VU cloud model per se lack detailed information on the vertical distribution of the cloud property retrievals. Under adiabatic conditions, the retrievals of the SAS and the HM models are equivalent, while the vertical distributions of the LWC, the effective radius and the optical extinction differ substantially under non-adiabatic conditions, especially at the cloud boundaries. The droplet concentrations of the SAS and HM models are very close to each other for both conditions. The model of uniform cloud properties yields values of the droplet concentration that are 25% lower than those from the models of non-uniform cloud properties. Interestingly, the differences between the cloud microphysical properties lead to very similar values of the retrieved visible optical depths. Sensitivity and error analyses suggest that the droplet concentration retrieval is generally most strongly affected by errors in the radar reflectivity and the LWP, while the retrievals of the effective radius are most robust in all three models. The retrievals of the optical depth and the effective radius are less affected by the variations in the DSD shape parameter as compared to the impact of the errors in observations. In contrast, the droplet concentration is more sensitive to changes in the gamma DSD shape parameter. Consequently the DSD shape parameter should be known a priori with reasonable precision. In order to evaluate the validity of the cloud property retrievals, the three algorithms are applied to synthetic surface remote sensing observations of a modeled liquid water cloud layer. The retrievals are compared with the physical properties of the modeled cloud layer as a function of the cloud height. Applying the algorithms to the best estimate \"observations\" and the assumed value for the DSD shape parameter leads to consistent HM model cloud property retrievals. In turn, significant overestimations of the SAS model LWC (50%) and the effective radius (10%) occur at cloud top where the SAS model retrieves the maximum values in the profiles. In all layers below the cloud top, the SAS cloud model retrievals of the LWC and the effective radius are very close to the modeled ones, because the true properties are increasing nearly adiabatically. As expected, the differences in the LWC and the effective radius profiles are largest upon the application of the VU model, which significantly overestimates both properties in the lower levels and underestimates them in the upper height levels. The very simple assumption that all cloud properties are uniformly distributed leads to a significant underestimation of the droplet concentration by about 20%. The SAS model droplet concentration is only slightly overestimated by 7%. Nevertheless, all cloud model retrievals of the optical depth agree well with those of the modeled cloud layer. To evaluate the performance of the cloud property retrievals obtained from real remote sensing observations, a broadband shortwave (SW) radiation closure analysis is performed for a selected water cloud case study. The SW fluxes at the surface calculated on the basis of the cloud properties of VU, SAS and HM models agree well with the surface radiation observations. The mean difference between the simulated and the measured SW fluxes is 2 W\/m2 to 5 W\/m2 with a standard deviation of 13W\/m2. The uncertainty in the simulated fluxes can be explained by the uncertainty in the LWC and the effective radius due to errors in the LWP, the reflectivity and the assumption on the gamma DSD shape parameter. The three presented retrieval methods provide reliable cloud optical depth values for the selected water cloud case study. The different vertical distributions of the LWC and the effective radius, as well as differences in the droplet concentration, have a minor effect on simulating SW fluxes, because they lead to similar values of the optical depth. The present work shows that the liquid water cloud property retrievals obtained from the remote sensing observations depend on the model that is used to describe the vertical cloud structure. It shows that systematic deviations between the microphysical cloud properties of the VU, SAS and HM cloud models exist, especially regarding the droplet concentration, the LWC, the effective radius and the optical extinction at the cloud boundaries. The cloud microphysical properties estimated using the HM model parametrization show the best performance. The SAS cloud model can represent the vertically resolved microphysical properties well if they are very close to being adiabatic. Clearly, there are significant deviations in the cloud microphysics from the clouds that are parameterized as being vertically homogeneous (VU model). The different combinations of the microphysical properties in the three models lead to almost equivalent VU, SAS and HM optical depth retrievals, which agree well with the values of the modeled liquid water cloud. They are all able to reproduce the surface shortwave broadband radiative flux. However, by modeling clouds as being vertically homogeneous, sufficient accuracy in both the microphysical and the optical property retrievals cannot be achieved.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":127975985,"openaccessinfo":{"externalids":{"MAG":"116471869","ACL":null,"DOI":"10.4233\/UUID:2A844DC9-0E89-43C7-A150-A89DB0C8327B","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper examines Japan's participation in global value chains (GVCs). To this end, we use plant-level data for Japan to split output in each industry in Japan's manufacturing sector into output for export or domestic sale and create an extended multi-country input\u2013output table (MIOT). We then compute trade in value added (TiVA) indicators to examine the participation of Japanese manufacturing plants in GVCs. Our estimates suggest that Japan's forward participation in GVCs is lower than suggested by estimates computed from a traditional MIOT. We infer that this result is due to high cross-border production fragmentation as well as the large presence of Japanese multinational companies in global manufacturing and the high volume of intra-firm trade in Japan's manufacturing sector. We conclude that considering firm heterogeneity in production for export and domestic sale in MIOTs provides a more accurate understanding of global production fragmentation.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":203149041,"openaccessinfo":{"externalids":{"MAG":"2970458010","ACL":null,"DOI":"10.1080\/09535314.2019.1657802","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examines understanding of living wills by patients, family members, and physicians. Questionnaires were used to examine whether each cohort understood patients' living wills regarding endotracheal intubation and cardiopulmonary rescuscitation (CPR). Of 4,800 patients admitted during the study period, 206 reported having living wills, all of which precluded intubation and CPR for \"terminal conditions.\" Of 140 admitted to the general hospital wards, 17 (12%) wanted their living wills to preclude intubation\/mechanical ventilation and 12 (8.6%) did not want resuscitation under any circumstances. Seven of 120 (6%) physicians and 4 of 108 family members would not intubate or perform CPR even if there was a chance of recovery. Of 88 patients with complete data (including physicians and family members), 29 (33%) wanted their living wills to block intubation\/mechanical ventilation only if they were deemed terminal and 46 (52%) wanted the living will to block intubation even if there was a 10% chance of recovery. Thirteen (15%) wanted to block intubation even if the chance of recovery was > or = 50. Results were similar for wishes regarding CPR. These data suggest substantial differences of patient, physician, and family member understanding of living wills. Living wills did not reflect fully patients' expectations of receiving (or not receiving) life-sustaining modalities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":597471,"openaccessinfo":{"externalids":{"MAG":"2032952317","ACL":null,"DOI":"10.1164\/RCCM.200206-503OC","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Church of England has received little attention either as an issue or as a force in mid-eighteenth-century politics. The contrast with the immediate post-revolutionary decades, when the Church and churchmen were at the centre of political debate, is striking. This development has been explained in terms of the achievement of political stability, one manifestation of which was the transition from the whig\u2013tory dichotomy of the reign of Anne into a court\u2013country one by 1725, with the issues dividing the two parties losing both ideological and political significance. Among the debates which were 'overtaken by events' was religion which 'ceased to be a central issue of political debate'. Indeed, Geoffrey Holmes has argued that the decline of religious controversy began with the Sacheverell trial, claiming that most of the eighteenth century was characterized by 'spiritual inertia' and 'religious tranquillity, within the framework of an Erastian polity'. Such views accord well with the secularist interpretation of the enlightenment, epitomized by Peter Gay's portrayal of it as 'a volatile mixture of classicism, impiety, and science', and they have been little challenged by ecclesiastical historians. Norman Sykes may have vindicated the pastoral and administrative standards of the Georgian Church, but the overwhelming impression remains one of Stability and intellectual torpor.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":159548140,"openaccessinfo":{"externalids":{"MAG":"2024794562","ACL":null,"DOI":"10.1017\/S0018246X00002211","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Association mining is one of the most researched areas of data mining and has received much attention from the database community. Association rules are interesting correlations among attributes in a database. These rules have many applications in areas ranging from e-commerce to sports to census analysis to medical diagnosis. The most time consuming operation in discovery of association rules is computation of frequency of interesting subset of items (called candidates) in the database of transactions. Hence, it has become vital to develop a method that may avoid or reduce candidate generation and test, utilize some novel data structures to reduce the cost in frequent pattern mining. An Effectual Generalized Mesh Transposition Algorithm (EGMTA) is proposed which is an integrated approach of Parallel Computing and ARM for mining Association Rules in Generalized data set. EGMTA is fundamentally different from all the previous algorithms. As EGMTA uses database in transposed form which has been done using Parallel transposition (Mesh Transpose), hence to generate all significant association rules number of passes required is reduced.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":2}},"corpusid":64615078,"openaccessinfo":{"externalids":{"MAG":"2788622875","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Computational approaches to transcription factor binding site identification have been actively researched for the past decade. \nNegative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well. \nHowever, understanding of the roles of negative examples in binding site search is still very limited. \nWe propose the 2-centroid and optimal discriminating vector methods, taking into account negative examples. Cross-validation results on E. coli transcription factors show that the proposed methods benefit from negative examples, outperforming the centroid and position-specific scoring matrix methods. We further show that our proposed methods perform better than a state-of-the-art method. We characterize the proposed methods in the context of the other compared methods and show that, coupled with motif subtype identification, the proposed methods can be effectively applied to a wide range of transcription factors. Finally, we argue that the proposed methods are well-suited for eukaryotic transcription factors as well. \nSoftware tools are available at: this http URL","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":2,"unknown":2}},"corpusid":14960711,"openaccessinfo":{"externalids":{"MAG":"1622873581","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1104.1234"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Acoustic feedback is a well-known problem in hearing aids, which is caused by the undesired acoustic coupling between the loudspeaker and the microphone. Acoustic feedback limits the maximum amplification that can be used in the hearing aid without making it unstable. The goal of adaptive feedback cancellation (AFC) is to adaptively model the feedback path and estimate the feedback signal, which is then subtracted from the microphone signal. The main problem in identifying the feedback path model is the correlation between the near-end signal and the loudspeaker signal, which is caused by the closed signal loop. A possible solution to this problem is to use the prediction error method (PEM)-based AFC with a linear prediction (LP) model for the near-end signal. In this paper, a modification to the PEM-based AFC is presented where the LP model is replaced by a sinusoidal near-end signal model. More specifically, it is shown that using frequency estimation techniques to estimate the sinusoidal near-end signal model improves the performance of the PEM-based AFC compared to using a LP model. Simulation results for a hearing aid scenario indicate a significant improvement in terms of misadjustment and maximum stable gain increase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":203562996,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose The purpose of this meta-analysis was to evaluate the overall safety and effectiveness of perioperative intravenous dexamethasone to facilitate postoperative rehabilitation in patients after total knee arthroplasty (TKA). Methods A comprehensive literature search was performed using the Embase, PubMed, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases for relevant randomized controlled trials (RCTs) from inception to 2020. Methodological quality of the trials was assessed using the Cochrane Risk of Bias Tool, and the relevant data were extracted using a predefined data extraction form. Results Ten RCTs with 1100 knees were included. Our study showed a significant reduction in pain using a postoperative pain visual analog scale (VAS) at 24 hours and 48 hours, total opioid consumption at 24 hours and 48 hours, postoperative nausea and vomiting (PONV), active range of motion (ROM) limitation, and passive ROM limitation at 72 hours in dexamethasone-treated groups compared with controls. Conclusion Intravenous low-dose dexamethasone is potentially useful in the perioperative setting for reducing postsurgical immediate ROM limitations, pain, opioid consumption, and PONV. There are no data that directly attribute an increase in postoperative complications to intravenous dexamethasone. More high-quality studies are necessary to draw these conclusions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232161347,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/0300060521998220","PubMedCentral":"7952853","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7952853","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper describes the development of a two degree of freedom (DOF) design for automated pedestrian crowd control barrier based on a closed-loop feedback control system. Since most of the barriers existing immobile, static and not adaptable to changing crowd condition, so this work provides an adaptive system that can assume strictly the role of the security man by sensing the crowd and move away to provide a safe area between crowd people and events area without collision. Kinematic and dynamic analysis to build the system is proposed, while planning trajectory is provided by suggesting some cases to control a specific current crowd situation using Computed Torque Controller (CTC), which identifies the difference between the input desired trajectory with the newly collected data of the equation of motion and dynamic equation analysis of the actual system to achieve a good and accuracy results by reducing the error and minimize the disturbances. Simulation studies for a straightforward range of motion exercise were carried out, and experimental validation for the automated barrier with two DOF is performed to move the system forward and backward and avoid any obstacle on its path. The results obtained shows that the controller can track the desired position and trajectories for the barriers system motion, and adequately adapt the control parameters to the crowd conditions and the sensor and motor control performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14396217,"openaccessinfo":{"externalids":{"MAG":"2338575780","ACL":null,"DOI":"10.1109\/IRIS.2015.7451605","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Portfolio optimization is to find the stock portfolio minimizing the risk for a required return or maximizing the return for a given risk level. The seminal work in this field is the mean-variance model formulated as a quadratic programming problem. Since it is not computationally practical to solve the original model directly, a number of alternative models have been proposed. \n \nIn this paper, among the alternative models, we focus on the Mean Absolute Deviation (MAD) model. More specifically, we derive bounds on optimal objective function value. Using the bounds, we also develop an algorithm for the model. We prove mathematically that the algorithm can solve the problem to optimality. The algorithm is tested using the real data from the Korean Stock Market. The results come up to our expectations that the method can solve a variety of problems in a reasonable computational time.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10548376,"openaccessinfo":{"externalids":{"MAG":"1540696237","ACL":null,"DOI":"10.15388\/INFORMATICA.2005.086","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a new method for jointly modelling the students' results in the university's admission exams and their performance in subsequent courses at the university. The case considered involved all the students enrolled at the University of Campinas in 2014 to evening studies programs in educational branches related to exact sciences. We collected the number of attempts used for passing the university course of geometry and the results of the admission exams of those students in seven disciplines. The method introduced involved a combination of multivariate generalised linear mixed models (GLMM) and graphical models for representing the covariance structure of the random components. The models we used allowed us to discuss the association of quantities of very different nature. We used Gaussian GLMM for modelling the performance in the admission exams and a frailty discrete-time Cox proportional model, represented by a GLMM, to describe the number of attempts for passing Geometry. \nThe analyses were stratified into two populations: the students who received a bonus giving advantages in the university's admission process to compensate social and racial inequalities and those who did not receive the compensation. The two populations presented different patterns. Using general properties of graphical models, we argue that, on the one hand, the predicted performance in the admission exam of Mathematics could solely be used as a predictor of the performance in geometry for the students who received the bonus. On the other hand, the Portuguese admission exam's predicted performance could be used as a single predictor of the performance in geometry for the students who did not receive the bonus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":231986460,"openaccessinfo":{"externalids":{"MAG":"3132510062","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2102.10565"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The book series Linguistische Arbeiten (LA) publishes high-quality work in linguistics that addresses current issues in synchrony and diachrony, theoretically or empirically oriented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":141674987,"openaccessinfo":{"externalids":{"MAG":"586071929","ACL":null,"DOI":"10.1515\/9783111345987","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Some highland landscapes in Northern Dalarna have been preserved by the ice-sheet's thermal regime that prevailed during the last glacial event and possibly, even during older ones. Those sites have a complex evolutionary history, where glacial and non-glacial landforms are juxtaposed, superimposed or combined. The aim of this study is to describe some of these landscapes as situated in Langfjallet, focusing on dierent groups of depressions, to review theories concerning the formation of analogous landforms and to propose an interpretation of their formation. Combinations of dierent remote sensing methods have been used to describe, map and document the depressions in the Langfjallet area. A group of depressions on Jakobshojden has been described, with special attention to the largest one. This conspicuous hollow has an atypical shape, steep walls and a well preserved rampart. The author rejects the idea of a glacial origin and formulates the hypothesis that the form might be a Pleistocene pingo-scar. Another group of at-bottomed depressions occurring on a ridge complex close to Havlingskappen is regarded as a moraine plateau system. The possibility that this moraine has the same origin as the Veiki moraines present in several localities in Northern Scandinavia is also discussed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":126945347,"openaccessinfo":{"externalids":{"MAG":"628440171","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Follow-up studies of very low birthweight (VLBW) infants have demonstrated that psychosocial as well as medical factors place infants at high risk for poor developmental outcome. Psychological resources of 40 new mothers were studied in a population of low-income Mexican-American women who delivered at Medical Center Hospital in San Antonio. Twenty subjects were mothers of VLBW infants (\u22641250 grams) and 20 were mothers of normal birthweight (NBW) infants. Groups were matched on year of infant's birth, birth order, sex ratio, ethnicity, years of education, and marital status. Prior to the infant's hospital discharge mothers completed the Rosenberg Self-Esteem and Pearlin Mastery Scales. Alpha reliability coefficients for the Self-Esteem Scale were .86 for the VLBW group and .65 for the NBW group (z=n.s.). For the Mastery Scale they were .78 and .34 (z=.04). Seventy percent of all mothers were found to have high levels of self-esteem and self-esteem was not related to birthweight group. Only 45% of VLBW mothers were found to have high levels of mastery and mastery scores were significantly related to self-esteem scores (r=.67) in the VLBW group. Contrary to expectations regarding the psychological resources of a low-income, minority population, mothers were found to regard themselves very positively, regardless of the infant's birthweight.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":22861226,"openaccessinfo":{"externalids":{"MAG":"1992237221","ACL":null,"DOI":"10.1203\/00006450-198404001-00119","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.nature.com\/articles\/pr1984198.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Simply presenting informa#ion that displays clearly any discrepancy between a teacher's ideal and actual classroom performance does not, in itself, promise constructive change. This is true in part because teachers confronted with such discrepancies often experience anxiety. Teachers who wish to change often find it difficult to behave differently in the classroom for a variety of reasons. This paper discusses some pSychological reactions that can be expected by teachers when they are confronted with information about their own classroom behavior. It also scojgests some actions that a cacilitator might take to help a teacher focus energies on self-improvement. (Author) U S DEPARTMENT OF HEALTH EDUCATION S. WELFARE NATIONAL INSTITUTE OF EDUCATION no, , r N PPC. I\"E PE 14,C.N Otft,,N Pl).N '1. 01 F 0111C N, DO NO, NE ,111 CifIC :A N1 0, ( N.Irf7NA, r :If E ION ,,IL071,17f OW y","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197636941,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To-date, conspicuous consumptions in both developed and developing countries remain on the rise. As a developing country, there is no exception for Malaysia. The luxury goods sector in Malaysia has been growing along with the rest of the world over the past thirteen years. Current research aimed to investigate conspicuous consumption through examining it from social media usage perspectives and the moderating role of self-esteem of consumers in the relationship between social media usage and conspicuous consumption. The framework of this study suggests that social media platform can cause social comparison among consumers, which the comparison domains are, wealth, status and attractiveness. These comparisons can lead to increasing motivation of acquisition of luxurious products and conspicuous consumption. The study also suggests that difference of high and low self-esteem is moderating the proposed relationship of social media usage and the propensity to consume conspicuously. A survey technique was conducted among 387 consumers using mall-intercept method at selected shopping malls to collect required data for analyses and the sample obtained consisted of Malaysian social media users aged above 18. Multiple regression and PROCESS analyses were conducted to test the correlation between social media usage and conspicuous consumption and moderation of self-esteem as proposed in the research framework. The result obtained indicates that social media usage has significantly influenced conspicuous consumption; and self-esteem was found significantly moderating the relationship between social media usage and conspicuous consumption. Overall, this study provides valuable insights on the understanding of conspicuous consumption and related variables that are influencing it such as social media usage and self-esteem. Consumers and authorities can benefit from these results to create awareness regarding the impact of these variables to ensure better purchase decision to be made by consumers..","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":198760521,"openaccessinfo":{"externalids":{"MAG":"2953789931","ACL":null,"DOI":"10.6007\/IJARBSS\/V9-I2\/5549","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was undertaken to determine whether hepatic lipogenesis plays a role in the exacerbation of copper (Cu) deficiency. Forty-eight male rats were fed from weaning a Cu-deficient or adequate diet containing 62% carbohydrate as either starch or fructose with or without clofibrate for 5 weeks. Clofibrate was fed since it had been shown to possess hypolipidemic properties. Administration of clofibrate reduced the activity of the lipogenic enzyme glucose-6-phosphate dehydrogenase. Total hepatic lipid, however, was not reduced. Clofibrate did not affect hepatic lipid concentration and the pathology associated with Cu deficiency when fructose was fed was not prevented by the consumption of clofibrate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24621777,"openaccessinfo":{"externalids":{"MAG":"2279209409","ACL":null,"DOI":"10.1080\/07315724.1992.10718243","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper describes how the use of bicycle helmets in Sweden has changed for different categories of cyclists from 1988 to 2002, and it also estimates future trends in voluntary wearing of bicycle helmets up to the year 2010. Observational studies of the use of bicycle helmets were conducted once a year from 1988 to 2002 at 157 sites in 21 cities. The subjects observed were children cycling to school (average n = 5471\/year) and in their free time (average n = 2191\/year), and adults cycling to workplaces and on public bike paths (average n = 29 368\/year). The general trend in helmet use from 1988 to 2002 was determined by linear regression analysis, and the results were also employed to estimate future helmet wearing for the period 2003-2010. Differences in helmet use according to gender and size of city were analysed by chi-square tests. From 1988 to 2002, all categories of cyclists showed an upward trend in helmet use (p < 0.01, p < 0.001). Helmet wearing increased from about 20 to 35% among children (< or =10 years) cycling during free time, from approximately 5 to 33% among school children, and from around 2 to 14% in adults. Total average helmet use rose from about 4 to 17%. However, during the last 5 years of the study period (1998-2002), none of the categories of cyclists studied showed an upward trend in helmet wearing. It is estimated that approximately 30% of cyclists will wear helmets voluntarily by the year 2010, if helmet promotion activities are continued at the same level as previously. The results suggest that Sweden will probably not reach its official goal of 80% helmet use unless a national bicycle helmet law is passed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1925139,"openaccessinfo":{"externalids":{"MAG":"2139429056","ACL":null,"DOI":"10.1093\/HEAPRO\/DAH505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the increasing advancement of Internet of Things (IoT) enabled systems, smart medical devices open numerous opportunities for the healthcare sector. The success of using such devices in the healthcare industry depends strongly on secured and reliable medical data transmission. Physicians diagnose that data and prescribe medicines and\/or give guidelines\/instructions\/treatment plans for the patients. Therefore, a physician is always concerned about the medical data trustworthiness, because if it is not guaranteed, a savior can become an involuntary foe! This paper analyses two different scenarios to understand the real-life consequences in IoT-based healthcare (IoT-Health) application. Appropriate sequence diagrams for both scenarios show data movement as a basis for determining necessary security requirements in each layer of IoT-Health. We analyse the individual entities of the overall system and develop a system-wide view of trust in IoT-Health. The security analysis pinpoints the research gap in end-to-end trust and indicates the necessity to treat the whole IoT-Health system as an integrated entity. This study highlights the importance of integrated cross-layer security solutions that can deal with the heterogeneous security architectures of IoT healthcare system and finally identifies a possible solution for the open question raised in the security analysis with appropriate future research directions.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":58003868,"openaccessinfo":{"externalids":{"MAG":"2910222590","ACL":null,"DOI":"10.1145\/3290688.3290731","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Aerva known as 'bui' is an under shrub with a long root, found in the wild, desert area belongs to the family Amaranthaceae. Different species are: persica, lanata, artemisioides, coriacea, humbertii, javanica, madagassica, microphylla, transvaalensis, revolute, sanguinolenta. It contains alkaloid, flavonoids, phenol, tannin, proteins, amino acids, steroids, saponins and carbohydrates. It have anthelmintic, demulcent, antiinflammatory, diuretic, hepatoprotective, hypoglycemic, anti-diabetic, anti-parasitic, anti-microbial, anti-asthmatic, anti-fertility, hypolipidemic and nephroprotective property. The herb is cultivated throughout India, Ceylon, Arabia, Tropical Africa, Java, Philippines.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":2,"unknown":2}},"corpusid":89203669,"openaccessinfo":{"externalids":{"MAG":"2521019633","ACL":null,"DOI":"10.4172\/2167-0412.1000187","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.4172\/2167-0412.1000187","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The metabolism of pyrimidine nucleotides in various tissues and tumor cells of rodents was investigated. Ribonucleoside diphosphate reductase, thymidine monophosphate kinase and DNA polymerase (alpha, beta) were specifically localized in tumor cells, i.e., the activities of these enzymes in tumor cells were at least three times higher than those in normal tissues, including rapidly growing tissues, such as bone marrow, thymus, and spleen. The activities of deoxycytidine monophosphate deaminase and all the nucleoside kinase were high not only in tumor cells, but also in rapidly growing normal tissues, so that these enzymes are unsuitable as targets for cancer chemotherapy. The tissue distribution of other enzymes, including orotate phosphoribosyltransferases, cytidine triphosphate synthetase, thymidine monophosphate synthase, nucleoside phosphorylases and cytidine deaminase had no relation with the cell growth rate. AH130 tumor cells and the thymus showed specific increases in the activities of enzymes involved in de novo DNA synthesis. In contrast, Yoshida sarcoma and bone marrow showed high activities of enzymes in the salvage pathway of DNA synthesis, which suggested that the two tumors have different patterns of nucleotide metabolism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21215919,"openaccessinfo":{"externalids":{"MAG":"2409124251","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Executive summary The focus of this paper is on the influence of the fast growth of organizations on the design process of management control systems. What are the management accounting and control problems that a fast growth organization encounters that can be ascribed to this growth. What are the circumstances arising from the fast growth of the organization that directly influence (re)design of the management control systems for the organization, and how can control help organizations with absorbing the negative effects of fast growth. The following paper outlines an explorative study into the subject.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54645042,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The interaction of matter with a quantized electromagnetic mode is considered. Representing a strong exciting field, the mode is assumed to contain a large number of photons. As a result, the material response is highly nonlinear: the completely quantized description results in generation of high harmonics. In order to understand the essence of the physical processes that are involved, we consider a finite dimensional model for the material system. Using an appropriate description in phase space, this approach leads to a transparent picture showing that the interaction splits the initial, exciting coherent state into parts, and the rapid change of the populations of these parts (that are coherent states themselves) results in the generation of high-order harmonics as secondary radiation. The method we use is an application of the discrete lattice of coherent states that was introduced by J. von Neumann.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204823987,"openaccessinfo":{"externalids":{"MAG":"3100140893","ACL":null,"DOI":"10.1103\/PhysRevA.101.013418","PubMedCentral":null,"ArXiv":"1910.09894"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Software Engineering Institute's (SEI) Capability Maturity Model for software (CMM) provides a well defined paradigm for software process improvement. Cleanroom software engineering provides well defined theoretical foundations and practices for software specification, development, testing and certification. The principal focus of the CMM is on management and organization. The principal focus of Cleanroom is on the technology and engineering discipline. The SEI has completed a study that maps Cleanroom into the CMM. The mapping shows that Cleanroom and the CMM are fully compatible, and that the technical practices of Cleanroom can be effectively integrated into the management practices of the CMM. The engineering discipline embodied in Cleanroom provides a firm foundation for project management, as illustrated in a software testing example.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":3}},"corpusid":262911,"openaccessinfo":{"externalids":{"MAG":"2165299488","ACL":null,"DOI":"10.1109\/HICSS.1997.661592","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper looks at the relationship between two British female writers, Virginia Woolf and Zadie Smith, in relation to the theories of the mirror stage and desire of the mother constructed by the prominent psychoanalyst, Jacques Lacan. Both Woolf and Smith discuss identity through their characters' reflection and social structures, and Lacan's insight into the human psyche allows me to read these two psychological authors. These two fields, literature and psychology, parallel each other, but Lacan is clinical and Woolf and Smith are subjective. I argue in my paper that Woolf and Smith, from two different generations (one is a modernist; the other, a postmodernist), differ as writers because Smith is more interested in social structures such as race and religion when reflecting on her characters' identities, whereas Woolf is more interested in the relationship between characters and introspection. This paper concludes that looking at British texts through a Lacanian lens is significant because it shows that there has been a shift in what is considered psychologically and sociologically relevant from Woolf's time to ours.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":209352750,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"THE CLINICAL course and the pathologic anatomy of the medulloblastoma have been repeatedly reported and clearly defined since the tumor was described to the American Neurological Association by Bailey and Cushing in 1924. 1 However, an interesting case of this tumor has directed my attention to the extensive study and conflicting nature of the theories dealing with its origin. The undifferentiated nature of the cells composing the neoplasm led the original authors to the belief that these cells, if of ectodermal origin, must be akin to the indifferenten Zellen of Schaper. Such cells had been previously identified (Pfleger) in heterotopic cellular groups in the region of the fourth ventricle, and Bailey and Cushing expressed the belief that \"if such an isolated and retarded group of undifferentiated cells should undergo a neoplastic transformation, just such a tumor as we have described might be expected to result.\" 1 Although this theory is","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":37070540,"openaccessinfo":{"externalids":{"MAG":"2084988246","ACL":null,"DOI":"10.1001\/ARCHNEURPSYC.1949.02310170128011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Weather forecasting plays a vital role in human daily routine, business and their decisions. The technology for weather forecasting is evolving rapidly due to the critical needs in obtaining the accurate prediction results. From the literature exploration, the researchers have found that weather data is important to be analysed in form of structure data. Most of data in weather is represented in unstructured data with different attributes such as temperature, humidity, visibility, and pressure. These data were captured by different types of sensors. The weather data consists of high volumes, high velocity and variety of data which is reflects to the characteristics of Big Data. In addition, these characteristics also contribute to the complexity on the data processing and prediction. Big Data analytics is a new concept to process the Big Data. For weather data, this new concept will help to organise the data into structure data. The well-known method for Big Data analytics is MapReduce Model. Nevertheless, the usage of MapReduce Model in processing weather dataset is not widely explored. Therefore, this research is focus on analysing the weather dataset using MapReduce Algorithm. The historical dataset in 10 years' period (1997 to 2007) has been used and this dataset is obtained from NOAA. This original dataset is stored in Hadoop Distributed File System. Next, MapReduce Algorithm is developed using Java programming. The algorithm is tested using small and big dataset. The temperature, humidity and visibility attributes from the dataset has been extracted by the MapReduce Algorithm into structure data. Graphical analysis has been used to represent the result from the MapReduce Algorithm. Results from the proposed algorithm have been compared with the existing model known as AWK (Alfred Aho, Peter Weinberger, and Brian Kernighan) model. The purpose of the comparison is to investigate the capability of the proposed model in parallel processing. The comparison results shown that MapReduce Algorithm has produced 37%, 25% and 11% less compared to AWK in term of processing time for 10GB, 5GB and 1GB data, respectively. This result has revealed the significant impact to the used of MapReduce Algorithm in weather prediction. In addition, the MapReduce results have discovered the significant pattern of temperature, humidity and visibility information which is valuable for the weather prediction.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":196058384,"openaccessinfo":{"externalids":{"MAG":"2803446591","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Arbitrary-precision integer multiplication is the core kernel of many applications in simulation, cryptography, etc. Existing acceleration of arbitrary-precision integer multiplication includes CPUs, GPUs, FPGAs, and ASICs. Among these accelerators, FPGAs are promised to provide both good energy efficiency and flexibility. Surprisingly, in our implementations, FPGA has the lowest energy efficiency, i.e., 0.29x of the CPU and 0.17x of the GPU with the same generation fabrication. Therefore, key questions arise: Where do the energy efficiency gains of CPUs and GPUs come from? Can reconfigurable computing do better? If can, how to achieve that? We identify that the biggest energy efficiency gains of the CPUs and GPUs come from the dedicated vector units. FPGA uses DSPs and lookup tables to compose the needed computation, which incurs overhead when compared to using vector units directly. New reconfigurable computing, e.g., 'FPGA+vector units' is a novel and feasible solution to improve energy efficiency. In this paper, we propose to map arbitrary-precision integer multiplication onto such a heterogeneous platform, i.e., AMD\/Xilinx Versal ACAP architecture. Designing on Versal ACAP incurs several challenges and we propose AIM: Arbitrary-precision Integer Multiplication on Versal ACAP to automate and optimize the design. AIM framework includes design space exploration and AIM automatic code generation to facilitate the system design and verification. We deploy the AIM framework on three different applications, including large integer multiplication (LIM), RSA, and Mandelbrot, on the AMD\/Xilinx Versal ACAP VCK190 evaluation board. Our experimental results show that AIM achieves up to 12.6x, and 2.1x energy efficiency gains over the Intel Xeon Ice Lake 6346 CPU, and NVidia A5000 GPU respectively, which brings reconfigurable computing the most energy-efficient platform among CPUs and GPUs.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-26":1,"unknown":2}},"corpusid":262083730,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2309.12275","PubMedCentral":null,"ArXiv":"2309.12275"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective:To evaluate the influence of postimplant dosimetric timing on prostate brachytherapy quality in community practice. Materials and Methods:The Pro-Qura database was stratified by multiple time intervals between the implant and postimplant dosimetric analysis. Postimplant dosimetry was performed in a standardized fashion. Criteria for implant adequacy included V100 >80%, D90 >90%, and V150 <60% for I-125 and <75% for Pd-103. Implants with V100 <80% and D90 <90% were deemed \"too cool.\" Implants were considered \"too hot\" if D90 >140% of prescription dose and\/or V150 >150% for I-125 and >75% for Pd-103. Results:For I-125, the average V100 and D90 increased from 88.6% to 89.8%, and 102.8% to 103.1% for day 0 and day 30 dosimetry. For Pd-103 implants the change was more pronounced, with V100 and D90 increasing from 81.6% to 87.8% (P < 0.001) and 88.7% to 100.0% (P < 0.001) for day 0, and day 30, respectively. The percentage of implants considered too cool based on a V100 and D90 criteria decreased from 18.8% and 26.9% on day 0 to 11.0% and 19.7% on day 30, respectively. Implants determined to be too hot based on a V150 >60% (I-125)\/>75% (Pd-103) or D90 >140% were 16.4% and 2.2% on day 0 and 16.0% and 0.7% on day 30, respectively. Conclusion:In community-based brachytherapy programs, postimplant dosimetry performed at day 30 resulted in a statistically and clinically significant improvement in postimplant dosimetry compared with day 0. The influence of timing is substantially greater for Pd-103 than I-125.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2114723,"openaccessinfo":{"externalids":{"MAG":"1997017885","ACL":null,"DOI":"10.1097\/COC.0b013e31816fc95a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this work is to analyze the pattern of environmental degradation in the cities and mesoregions of the State of Parana, creating a Degradation Index. In this sense, we studied 27 variables from 399 cities in the year of 2006. The average value of the environmental degradation of the cities is 67.76 %. This value is a significant number and demonstrates that more than half of the State of Parana area faces problems related to environmental degradation. Regarding the cities, it can be seen that many of them have 100 % of relation with the Degradation Index. These cities and their mesoregions have a direct connection with the agricultural activity, which confirms the involvement of this activity in the aggravation of the phenomenon. Furthermore, issues such as rural poverty and natural limitations can aggravate the situation of environmental degradation. However, family agriculture practices as well as improvement in environmental education may reduce these rates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":127734990,"openaccessinfo":{"externalids":{"MAG":"325843871","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Drug abuse is a major public health problem among the youth worldwide especially in developing countries. The accessibility, affordability, and consumption of abused drugs by the youths have attracted great concern among public health personnel. The impact of drug abuse in human health and well-being is substantial and its contribution ranges from medical, social, family, legal and economic problems which are created by its uncontrolled use. Thus, drug abuse-related problems among the youth cannot be ignored. Evidence from around the world reveals that there is an upward trend in the misuse of psychoactive drugs among the youth. There is limited documented information on the extent of drug abuse among secondary school students Kisumu Town East, Kenya. The main objective of this study was to assess family environment related factors that influence drug and substance abuse among secondary school students in Kisumu Town East, Kenya. The findings of the study would be used to guide policy in the control and prevention of drug abuse in secondary schools. Descriptive cross-sectional study design was used in the study. Stratified sampling was used to determine the number of boys' schools, girls' schools and mixed schools to be selected. A total of eight schools were sampled proportionately in the ratio of 1:1:6 (boys, girls and mixed) respectively. The study population in this study was students in public secondary schools in Kisumu town, Kenya.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":218276149,"openaccessinfo":{"externalids":{"MAG":"2242327709","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives To report a rare histopathological diagnosis of adnexal mass. Methods We describe a case of a patient referred to our Gynecology Oncology service to investigate an adnexal mass found in routine exams. Results A 58-year-old woman was referred to our service due to an adnexal mass associated with hypogastric pain. Physical examination revealed a hardened mass bulging the anterior-right vaginal wall, discreetly painful by the touch. A magnetic resonance imaging (MRI) of the pelvis revealed a right adnexal heterogeneous mass measuring 9,5 x 4,5 x 6,5 cm adjacent to the iliac vessels. There were no altered tumoral markers. She underwent to exploratory laparotomy, and a mass in the right broad ligament was found. Bilateral salpingoophorectomy and total hysterectomy was performed, as well as the excision of the tumor (wich was adhered to the right iliac vein, pelvic wall and obturator fossa) and homolateral pelvic lymphadenectomy. The intraoperatory pathologic evaluation of the lesion suggested a Carcinoma. The anatomopathologycal study of the retroperitoneal tumor was consistent with poorly differentiated malignant neoplasm. The immunohistochemical analysis showed a strong and diffuse expression of CD23 and negative expression of other markers, ruling out the previous diagnosis and bringing to light the actual histology of the tumor, follicular dendritic cell sarcoma (FDCS). Conclusions It is known that FDCS is an uncommon lymphoid neoplasm, especially in pelvic location, with low incidence and indolent growth, difficult to diagnose, but with high rates of local recurrence and eventually distant metastases. There is no standard treatment established and adjuvant therapy is still controversial.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":203820069,"openaccessinfo":{"externalids":{"MAG":"2973339132","ACL":null,"DOI":"10.1136\/ijgc-2019-IGCS.362","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present study examines peptide YY responses to regional intestinal perfusion of fatty acids of different chain length--dodecanoate and oleate. Six dogs with chronic gastric, duodenal, and jejunal fistulas were studied. Proximal perfusates were administered into the duodenum and diverted through an intestinal fistula placed 45 cm beyond the duodenal cannula. Distal perfusates were administered into the caudal stoma of this intestinal stoma. Peptide YY responses to proximal, distal, and whole-gut perfusion were compared. Proximal perfusion with oleate or dodecanoate failed to release peptide YY. In contrast, distal and whole-gut perfusion with either fatty acid produced significant increases that were of similar magnitude. Immunocytochemical studies demonstrated that peptide YY cells predominated in the canine ileocolonic mucosa and decreased progressively in an orad direction. We conclude that peptide YY release is not dependent on fatty acid chain length and that the duodenum does not play a dominant role in peptide YY release. As such, peptide YY release differs from that of its cousin pancreatic polypeptide and may result at least in part from direct stimulation of the peptide YY cell in the ileocolonic mucosa.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":33101586,"openaccessinfo":{"externalids":{"MAG":"2416708209","ACL":null,"DOI":"10.1152\/AJPGI.1985.249.6.G745","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We suggest that Anderson localization can be reached for classical waves for a very small concentration of scatterers, if they present internal resonances. Applications, e.g., to acoustics in a bubbly liquid are shown to reach the strong localization regime, with scatterers volume fraction as small as 10\u22124 \u00f7 10\u22125. Localization of photons is also discussed. Our systems could allow a clear study of the mobility edge.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121551253,"openaccessinfo":{"externalids":{"MAG":"2061905231","ACL":null,"DOI":"10.1209\/0295-5075\/7\/3\/014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Fast ion velocity distribution is investigated using ICRF minority heating in Heliotron J with special emphasis on the effect of the toroidal ripple of magnetic field strength. The effect of the magnetic configuration on the fast ion confinement is one of the most important issues in helical devices. Here, the pitch angle dependences of energy spectra for three bumpy cases are measured for the first time, then, the fast ions up to 34 keV are observed in the high bumpy case during ICRF heating in Heliotron J. The configurations used in this study are as follows; the bumpiness (B04\/B00, where B04 is the bumpy component and B00 is the averaged magnetic field strength) are 0.15 (high), 0.06 (medium) and 0.01 (low) at the normalized radius of 0.67. The configuration of B04\/B00 = 0.06 corresponds to the standard configuration in Heliotron J. In high bumpy cases, the higher energy flux is measured near 120 deg in pitch angle although the ions are considered to be accelerated in the perpendicular direction by ICRF heating. To understand experimental results, Monte Carlo calculation is performed. The numerical model consists of orbit tracing, Coulomb collisions and acceleration by the ICRF heating. Minority protons are regarded as test particles and the heating is simulated by the velocity kick in the perpendicular direction in velocity space when ions cross the cyclotron layer. The calculation results using Monte Carlo method represents that the accelerated ion distribution has its peak in the range between 20 deg and 30 deg from the perpendicular direction. This result is considered to be caused mainly due to the existence of the loss region around the perpendicular direction.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":15585742,"openaccessinfo":{"externalids":{"MAG":"2787832912","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo study the pathogenesis role of immune system activation in AIDS related Kaposi's sarcoma(AIDS-KS).\n\n\nMETHODS\nThe serum levels of sFas, beta 2-microglobin, IL-10, IL-16, IL-18, IL-6 and sIL-4R were detected by ELISA in 8 AIDS-KS patients, 28 patients with HIV infection but without Kaposi's sarcoma(HIV-NKS) and 16 normal controls. The lymphocyte and their subsets, CD38(+) CD8, HLA-DR(+)CD8 in the peripheral blood mononuclear cell (PBMCs) in 12 AIDS-KS and 32 HIV-NKS were detected by flow cytometer.\n\n\nRESULTS\nBeta 2-MG and sIL-4R in HIV-NKS were significantly higher than those in normal controls(P<0.05), IL-16 in HIV-NKS was significantly lower than that in controls(P<0.05). IL-18 was higher in both AIDS-KS and HIV-NKS compared with normal controls. In AIDS-KS, CD3, CD4, CD8, NK and HLA-DR(+)CD8 were lower than those in HIV-NKS whereas CD19 and CD38(+)CD8 were higher than those in HIV-NKS. But the difference was not statistically(P<0.05).\n\n\nCONCLUSION\nAlthough both AIDS-KS and HIV-NKS demonstrate some activation of immune system, there appears to be no significant difference between immune responses in KS and NKS patients. These data suggest that the activation of the immune system is unlikely to contribute significantly to the pathogenesis of AIDS-KS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40927761,"openaccessinfo":{"externalids":{"MAG":"2465844308","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intestinal ischemia\/reperfusion (I\/R) injury initiates a systemic inflammatory response syndrome with a high associated mortality rate. Early diagnosis is essential for reducing surgical mortality, yet current clinical biomarkers are insufficient. Metabonomics is a novel strategy for studying intestinal I\/R, which may be used as part of a systems approach for quantitatively analyzing the intestinal microbiome during gut injury. By deconvolving the mammalian-microbial symbiotic relationship systems biology thus has the potential for personalized risk stratification in patients exposed to intestinal I\/R. This review describes the mechanism of intestinal I\/R and explores the essential role of the intestinal microbiota in the initiation of systemic inflammatory response syndrome. Furthermore, it analyzes current and future approaches for elucidating the mechanism of this condition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19438737,"openaccessinfo":{"externalids":{"MAG":"1986964828","ACL":null,"DOI":"10.2217\/bmm.09.11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The current study aimed to develop novel pH independent microparticles loaded with ropinirole (ROP) for sustained drug release. Eudragit RS 100 was used as release retardant and microparticles were fabricated by oil-in-oil emulsion solvent evaporation method. A three-factor three-level Box-Behnken design using Design-Expert software was employed to optimize formulation variables. Ropinirole loaded microparticles were evaluated with respect to morphology, particle size, encapsulation efficiency, and in vitro release profile. Optical microscopy and SEM micrographs indicated spherical shape with smooth surface and well-defined boundary. The particle size was in the range of 98.86 to 236.29 \u03bcm, being significantly increased with increasing polymer concentration. Higher polymer load also increased the thickness of internal polymer network, which led to reduced drug loss and higher entrapment efficiency (89%). The cumulative in vitro release was found to be in the range of 54.96 to 99.36% during the release studies (12 h) following zero order release kinetics and non-Fickian diffusion pattern. The developed microparticles have the potential to sustain the release of ropinirole, which may lead to a reduction in its adverse effects and improved management of Parkinson's disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4581892,"openaccessinfo":{"externalids":{"MAG":"2555512183","ACL":null,"DOI":"10.1208\/s12249-016-0653-5","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND OBJECTIVE\nHepatic ischemia-reperfusion injury (HIRI) results in serious complications after liver resection and transplantation. Edaravone (ED) has a protective effect on IRI. This study was designed to evaluate whether ED could protect the liver of rats from HIRI injury and explored its exosomal miRNA-related mechanism.\n\n\nMETHODS\nThe sham group, hepatic ischemia\/reperfusion (IR group), and hepatic ischemia\/reperfusion + edaravone (ED group) models were established. We determined the protective effect of ED by measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD); enzyme-linked immunosorbent assay for tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-1\u03b2 (IL-1\u03b2); hematoxylin-eosin staining and immunohistochemistry for histopathological changes. Exosomal miRNAs were subjected to second-generation sequencing to identify their differential expression. The results were analyzed using bioinformatics methods and validated using real-time quantitative polymerase chain reaction (RT-qPCR).\n\n\nRESULTS\nHIRI rats showed higher levels of ALT, AST, oxidative stress, and inflammatory markers; ED attenuated these effects. The sequencing results showed 6 upregulated and 13 downregulated miRNAs in the IR vs. sham groups, 10 upregulated and 10 downregulated miRNAs in the ED vs. IR groups. PC-3p-190-42101 was screened as an overlapping differentially expressed miRNA, and RT-qPCR validation showed that its expression in HIRI rats was significantly decreased; ED prevented this downregulation. Moreover, the expression of PC-3P-190-42101 was significantly correlated with the level of inflammatory factors.\n\n\nCONCLUSION\nThese findings indicate that ED can regulate the level of inflammatory factors by affecting the expression of miRNA PC-3p-190-42101 in plasma exosomes to protect the liver from IRI.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244774020,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2174\/1874467214666211130162152","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Short rib polydactyly syndromes (SRPS) and Jeune's asphyxiating thoracic dystrophy (JATD) belong to a heterogeneous group of autosomal recessive skeletal disorders characterized primarily by short, horizontal ribs, short limbs, and variable polydactyly. Mutations in fourteen genes affecting primary cilia function cause SRPS and JATD, but they do not account for all cases. To define the contribution of known genes and identify additional genes that are essential for skeletal development, we performed whole-exome sequencing on a cohort of 143 cases.We identified mutations in known genes present in the homozygous or compound heterozygous state in 102 cases (71%). In addition, 9 cases (6%) were compound heterozygous or homozygous for mutations in 7 candidate genes, including DYNC2LI1, ICK, and ADRBK1.We found mutations in DYNC2LI1 segregating with disease in three families. Using primary fibroblasts, we showed that DYNC2LI1 is essential for dynein-2 complex stability and that mutations in DYNC2LI1 result in variable-length, including hyperelongated, cilia, Hedgehog pathway impairment, and ciliary IFT accumulations.We found a homozygously-inherited missense mutation in the serine\/threonine kinase, ICK, in one individual with SRPS II. We show that the mutation abolishes kinase activity, causes aberrant ICK subcellular and ciliary localization, increases cilia length, and results in Hedgehog signaling defects. Further, loss of ICK kinase function inappropriately activates MAPK kinase signaling (ERK).Finally, we detail how a homozygously-inherited nonsense mutation in ADRBK1 causes JATD without affecting ciliogenesis. Using patient fibroblasts and frozen femur growth plate, we show that loss of ADRBK1 results in profound disruption of growth plate signaling and organization.The discovery of these novel disease-producing genes highlights the remarkable genetic heterogeneity of the skeletal ciliopathies and illustrates the complex nature of signaling through the primary cilium.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":88942549,"openaccessinfo":{"externalids":{"MAG":"2462566573","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. The molecular and functional characterization of transport proteins is emerging rapidly and significant numbers of drugs have been shown to be substrates or inhibitors. The purpose of this review is to highlight the in vivo preclinical and clinical evidence that supports a role for transport proteins in attenuating the absorption, distribution and excretion (ADE) of drugs. 2. For absorption, a clear role has emerged for P-glycoprotein in limiting permeability across the gastrointestinal tract. As a result, a wide variety of drugs suffer from incomplete, variable and non-linear absorption. Similarly, at the blood-brain barrier a range of drugs has limited brain penetration due to P-glycoprotein-mediated efflux, which can limit therapeutic effectiveness of CNS agents. In the liver, transport proteins are present on the sinusoidal membrane that can be the rate-limiting step in hepatic clearance for some drugs. Mechanistic studies clearly suggest a key role and broad substrate specificity for the OATP family of sinusoidal transporters. Mainly ATP-dependent transport proteins such as P-glycoprotein and MRP2 govern active biliary excretion. 3. Drug-drug interactions have been demonstrated involving inhibition or induction of transport proteins. Clinically significant interactions in the gastrointestinal tract and kidney have been observed with inhibitors such as ketoconazole, erythromycin, verapamil, quinidine, probenecid and cimetidine. Clinically significant inhibition at the blood-brain barrier is more difficult to demonstrate, relying on pharmacodynamic and toxicodynamic changes, but an example is quinidine increasing loperamide-induced central effects in humans. 4. This review highlights the emerging role of transport proteins in ADE of drugs and suggests these need to be considered, in drug discovery and development, with respect to variability in drug disposition and response.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46165903,"openaccessinfo":{"externalids":{"MAG":"2092118786","ACL":null,"DOI":"10.1080\/00498250110060969","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we explore the influence of band selection and dimensionality reduction of hyperspectral data on three point target detection algorithms. We wish to reduce the computational burden and to maximize the algorithms' performance by taking into consideration high spectral correlation. In order to measure the discrimination capability of target detection algorithms, we implemented a metric to quantitatively evaluate our algorithm for a particular combination of target signature, spectral cube, and bands chosen. Band selection was done in several ways; we evaluate our results both with exhaustive search and a \"sub-optimal\" selection algorithm.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":18163222,"openaccessinfo":{"externalids":{"MAG":"2158034462","ACL":null,"DOI":"10.1109\/IGARSS.2010.5653628","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of the Research Centre ZEB is to eliminate greenhouse gas emissions from buildings. Reducing the energy consumption in buildings is a means to that end. The use of membrane based plate heat exchangers can allow for recycling of energy in exhaust air, thereby reducing the overall energy spent on heating and regulating humidity of supply air. Such heat exchangers have been studied in warm, humid climates to a much greater extent than in cold climates. The objectives of this study was to build a rig for testing of heat exchangers in cold climates, build a membrane based quasi-counter flow heat exchanger and investigate if frost formation would occur in this heat exchanger. The rig was built in accordance with relevant standards for testing of heat exchangers. The heat exchanger was built with durability, mechanical stability and low cross contamination in mind. One membrane material was utilized through three different tests. In all tests freezing did occur. The frost was found only in the exhaust air channels, whereas the supply air channels were dry and frost free. Although the whole membrane surface had frost formation, the densest frost was found in the areas with the lowest temperatures and air flow rates. The tested material was therefore found unsuitable for use in cold climates.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":106738697,"openaccessinfo":{"externalids":{"MAG":"635794497","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Surgical resection is the mainstay treatment for gastrointestinal stromal tumors (GISTs). Laparoscopic surgery can be considered for treating these tumors since their biologic behavior lends them to curative resection without requiring large margins or extensive lymphadenectomy. Despite complete resection, GISTs frequently recur specifically in the liver and peritoneum. Although they occur in other upper gastrointestinal malignancies, recurrences of GISTs at the port sites after laparoscopic surgery have rarely been reported. We describe here a patient with abdominal wound metastasis after laparoscopic surgery for GIST.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44389106,"openaccessinfo":{"externalids":{"MAG":"2044707866","ACL":null,"DOI":"10.5009\/gnl.2010.4.2.283","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.5009\/gnl.2010.4.2.283","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Industrial wastewater containing organic compounds and\/or substances is an increasing problem due to its increasing toxic threat to humans and the environment. The removal of organic compounds has become an imperative issue due to stringent measures that are introduced by the Department of Environmental Affairs in South Africa to enforce regulations concerning wastes that emanate from petrochemical industries. Thus, wastewater containing these compounds must be well understood so as to device adequate treatment processes. In this study, the adsorptive capacity of PAD 910 polystyrenic resin originating from China and granular activated carbon (GAC) was evaluated for the removal of benzene, toluene, ethylbenzene and isomers of xylene (BTEX) from an aqueous solution. Batch studies were performed to evaluate the effects of various experimental parameters such as mixing strength, contact time, internal diffusion, adsorbates and initial concentration on the removal of the BTEX compounds. The experiments were conducted at the mixing strength of 180 rpm, in order to comfortably assume negligible external diffusion. The equilibrium isotherms for the adsorption of the adsorbates on the PAD 910 polystyrenic resin were analyzed by the Langmuir, Freundlich and linearized Dubinin-Radushkevich models at a pH of 5.86. The Langmuir model fitted the data adequately; this result was supported by the work done by Site (2001) which concluded that the Langmuir is the most practical model in representing the adsorption of aromatic compounds. The Langmuir model indicated that resin has the highest adsorption capacity of 79.44 mg\/g and GAC has 66.2 mg\/g. Resin was found to adsorb 98% of benzene, 88% of toluene, 59% of ethylbenzene, 84% m-;p-xylene and 90% o-xylene at an initial concentration of 14.47 mg\/l. BTEX adsorption was a two-stage process: a short, fast initial period then followed by a longer, slow period corresponding to the intra-particle diffusion of BTEX molecules in macropores and micropores. The adsorption capacity was determined by total surface area accessible to BTEX and the availability of active surface chemical groups. The dependence of adsorption capacity on the surface of the two adsorbents and temperature was observed, suggesting the chemical nature of the BTEX adsorption. The interaction between BTEX\/activated carbon was however weak and energetically similar to that of hydrogen bonds. Generally, BTEX adsorption was an exothermic process that combined physisorption and chemisorption. The PAD 910 polystyrenic resin had a greater specific surface area (SSA) of 1040 m2\/g which yielded in higher capacity compared to GAC which had a low SSA of 930 m2\/g. The normalized adsorption capacity was found to be higher for PAD 910 polystyrenic resin than GAC (0.66 and 0.27 mg\/m2 respectively) which suggests that the resin has a good potential of the adsorbent for removing BTEX compound compared to GAC. Fixed bed columns were used to evaluate the dynamic adsorption behaviour of BTEX\/PAD 910 polystyrenic resin through a dynamic column approach. The performance of small-scale fixed bed columns, each containing PAD 910 polystyrenic resin and the other containing GAC were evaluated using 14.47 mg\/L of BTEX concentration. The columns with 32 mm diameter, studied bed depths of 40, 80 and 120 mm and flow rate of 6 ml\/min were used in order to obtain experimental breakthrough curves. The bed depth service time (BDST) model was used to analyze the experimental data and design parameters like adsorption capacity, adsorption rate and service time at 20% and 60% breakthrough. BDST was also used to predict the service times of columns operated under different influent concentrations and flow rates to produce theoretical values that were compared to the experimental values. Adsorption model by Dubinin and colleagues (Dubinin, 1960), based on the theory of volume filling micropores was used to fit the measured adsorption isotherms. Agreement between the modelled and experimental results for GAC and PAD 910 polystyrenic resin using Dubinin-Radushkevich equation generally improved with increasing the surface area and produced reasonable fits of the adsorption isotherms for both GAC and PAD 910 polystyrenic resin. Granular activated carbon had a lesser performance compared to the PAD 910 polystyrenic resin, in terms of kinetic studies, and this finding was attributed to the pore structure which made accessibility of BTEX molecules more difficult in this study. The results indicate that PAD 910 polystyrenic resin show potential as an adsorbent for removing low concentrations of BTEX from wastewater. It is suggested that necessary treatment of GAC might improve the performance of this adsorbent by creating more mesopore volume and fraction which is essential to enhance adsorption rate. A substantial different SSA could be achieved through high porosity development in GAC by using templating method with a higher potassium hydroxide mixture ratio.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":263505428,"openaccessinfo":{"externalids":{"MAG":"2380816151","ACL":null,"DOI":"10.51415\/10321\/1496","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.51415\/10321\/1496","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The intrinsic instability of organic electrolytes seriously impedes practical applications of high-capacity metal (Li, Na) anodes. Ion-solvent complexes can even promote the decomposition of electrolytes on metal anodes. Herein, first-principles calculations were performed to investigate the origin of the reduced reductive stability of ion-solvent complexes. Both ester and ether electrolyte solvents are selected to interact with Li+ , Na+ , K+ , Mg2+ , and Ca2+ . The LUMO energy levels of ion-ester complexes exhibit a linear relationship with the binding energy, regulated by the ratio of carbon atomic orbital in the LUMO, while LUMOs of ion-ether complexes are composed by the metal atomic orbitals. This work shows why ion-solvent complexes can reduce the reductive stability of electrolytes, reveals different mechanisms for ester and ether electrolytes, and provides a theoretical understanding of the electrolyte-anode interfacial reactions and guidance to electrolyte and metal anode design.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52983772,"openaccessinfo":{"externalids":{"MAG":"2897239983","ACL":null,"DOI":"10.1002\/anie.201809203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Concentration of the Theatrical Distribution Market in Spain Globalization has been re-opened the debate on the concentration of media companies. Whe- reas some authors consider that the dominant position of U.S. companies comes from the higher identification of American films with the tastes of the European audience, others, on the contrary, argue that is the control of the distribution system what explains the Hollywood success. This paper analyses the Spanish film market, focused on the theatrical distribution sec- tor. For this, it addresses a triple aim: first of all, to identify the degree of concentration in the Spanish film distribution market; secondly to analyse the links between U.S. movies' box office success and the dominant position of the Hollywood majors; and, lastly, to evaluate the effects of this situation on the performance of Spanish and European films in the domestic market.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":140519378,"openaccessinfo":{"externalids":{"MAG":"2770552169","ACL":null,"DOI":"10.7238\/A.V0I47.1894","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present world scenario health is of a major concern. The heart rate forms a vital measure of a person's health. It helps to monitor the body's present condition and hence provide ways to improve it, if there are any ailments. Presently the heart rate of a person is measured using equipment like stethoscope and electrodes which require the person to be present physically. In current scenario, people or public is realizing too late to receive serious medical care when things are non-invertible. On the other hand access too many medical equipment is difficult and expensive. In order to overcome these drawbacks a system that remotely monitors the heart rate is required and to play music depending on the heart rate to accolade work out regimes. The main objective of this paper is to design and develop a system that remotely monitors the heart rate and to play music depending on the tune of heartbeat to compliment exercise regimes. A pulse sensor circuit is designed to obtain the heart beats per minute (bpm). The output of the sensor is sent to the Arduino Ethernet shield's web server. People can monitor physical status of the patent remotely from the web. The heart rate is obtained from the heart rate sensor. Based on the heartbeat obtained the Arduino is programmed to play a music accordingly. In order to play a music Arduino is connected to the Audio shield, which plays music depending on the human heart rate, the heart rate of the patient can be viewed by entering the IP (internet protocol) address of the client's Arduino Ethernet shield on the web browser. It is observed that the obtained heart rate will have a maximum error value of 2 bpm and music are played using Arduino audio player depending on the heart rate.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":22123202,"openaccessinfo":{"externalids":{"MAG":"2181860697","ACL":null,"DOI":"10.1109\/GCCT.2015.7342748","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The experiments on 25 dogs have shown a considerable decrease in the consumption of clotting factors and reduced hyperfibrinolysis with the onset of disseminated intravascular coagulation syndrome in animals poisoned with acetic essence (2 ml\/kg).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11155005,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider a generalisation of the classical Fibonacci sequence, and by the use of function theoretic methods, generate binomial type series which may be expressed in closed form. Some new identities are also given.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62818829,"openaccessinfo":{"externalids":{"MAG":"2130658619","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives. The purpose of this study was to compare the oral health behavior of mothers and children from multicultural families and those of mothers and children from ordinary Korean families. Methods. The subjects in this study were 175 mothers of ordinary Korean families and 131 mothers of multicultural families who were selected by convenience sampling from the city of Nonsan. The investigation method was a personal self-administration survey conducted on the mothers of ordinary Korean families, and an interview survey conducted on the mothers of multicultural families by personal visit. The collected data were analysed using a t-test and chi-square test using SPSS software. Results. The multicultural families were far more disadvantaged than the ordinary Korean families when their socioeconomic characteristics were compared. The frequency of cariogenic beverages intake of children from multicultural families was higher than in children from ordinary Korean families. However, the types of families made no differences on how much the mothers curbed their children's sugar intake to prevent dental caries. Both of the mothers and children from multicultural families brushed their teeth less frequently than the mothers and children from ordinary Korean families, and the multicultural families brushed their teeth less after lunch and before bedtime. Conclusions. The mothers and children from multicultural families had non-desirable oral health behavior when compared to the mothers and children from ordinary Korean families. A supportive environment has to be established to improve the oral health of multicultural families in Korea.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59351843,"openaccessinfo":{"externalids":{"MAG":"2902603115","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reviews key trends in migration patterns within and from Ethiopia over the last century, with a particular focus on 1960 onwards when more national-level data is available. It shows that both gradual and dramatic shifts characterize Ethiopia's migration history. Regarding gradual shifts in the movement of populations within the country, Ethiopia shows a two-fold process of sedentarization of nomadic and semi-nomadic lifestyles alongside a slow but steady urbanization of internal migration trajectories. Alongside this, rising levels of international migration have diversified in terms of the composition and destinations of Ethiopian emigrants. Ethiopia's history also shows more punctuated and dramatic shifts in population movements over relatively short periods \u2013 a consequence of political conflict, famine, conscription, resettlement schemes, and\/or development-induced displacement. At the same time that Ethiopians left their country in times of distress, Ethiopia was also an important destination for hundreds of thousands of refugees from neighboring countries in the Horn of Africa. This paper provides evidence for these trends, and considers how they relate to other processes of social change. In particular, it applies a social transformation framework to show how different dimensions of social change \u2013 the political, economic, cultural, technological and demographic \u2013 impacted population movements over time. We distinguish between 'deep' drivers of migration transitions (e.g. the expansion of formal education, infrastructure development and industrialization) and the (often) stateled policy interventions (and failures) that can suddenly affect the movements of large segments of the population (e.g. resettlement programs, development-induced displacement, political conflict, or famine). We ultimately argue that while migration driven by the latter can be addressed and mediated through policy-interventions, overarching migration transitions driven by the former are part and parcel of development strategies in the modern period, and are thus unlikely to be significantly affected by policies aimed at stemming migration's 'root causes.'","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":202305448,"openaccessinfo":{"externalids":{"MAG":"2969581623","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Streaming video using P2P network has gained its popularity as it utilizes the upload bandwidth of the participating peers and alleviates the bandwidth consumption of the streaming server. However, delivering video to a variety of decoding devices over heterogeneous network is a new challenge. In this paper, we propose a system that adopts SVC (Scalable Video Coding) to deal with the heterogeneous environment (including network, display and computational capabilities, etc.), and using Network Coding (NC) to eliminate the hierarchical relationship of SVC packets. At the source server, video is coded by NC according to the priority of layers; at the intermediate nodes, NC is used by mixing the transmitted packets. then, a packetization scheme tailored to NC delivery is discussed in detail. The proposed scheme can make full use of available bandwidth and reduce the delay, and it enables efficiently video delivery to heterogeneous receivers. Simulation results show that the proposed scheme yields a superior video quality and great bandwidth saving compared to the ordinary NC.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":16679355,"openaccessinfo":{"externalids":{"MAG":"2145074461","ACL":null,"DOI":"10.1109\/CISP.2009.5302005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. A detailed spatial geodatabase of aufeis (or naled in Russian)\nwithin the Indigirka River watershed (305\u2009000\u2009km2), Russia, was compiled\nfrom historical Russian publications (year 1958), topographic maps (years\n1970\u20131980s) and Landsat images (year 2013\u20132017). Identification of aufeis\nby late spring Landsat images was performed with a semi-automated approach\naccording to Normalized Difference Snow Index (NDSI) and additional data.\nAfter this, a cross-reference index was set for each aufeis field to link and\ncompare historical and satellite-based aufeis datasets. The aufeis coverage varies from 0.26\u2009% to 1.15\u2009% in different sub-basins\nwithin the Indigirka River watershed. The digitized historical archive\n(Cadastre, 1958) contains the coordinates and characteristics of 896 aufeis\nfields with a total area of 2064\u2009km2. The Landsat-based dataset included 1213\naufeis fields with a total area of 1287\u2009km2. Accordingly, the\nsatellite-derived total aufeis area is 1.6 times less than the Cadastre\u00a0(1958)\ndataset. However, more than 600 aufeis fields identified from Landsat images\nare missing in the Cadastre\u00a0(1958) archive. It is therefore possible that\nthe conditions for aufeis formation may have changed from the mid-20th\ncentury to the present. Most present and historical aufeis fields are located in the elevation band\nof 1000\u20131200\u2009m. About 60\u2009% of the total aufeis area is represented by\njust 10\u2009% of the largest aufeis fields. Interannual variability of aufeis area for the period of\n2001\u20132016 was assessed for the Bolshaya Momskaya aufeis and for a group of\nlarge aufeis fields (11 aufeis fields with areas from 5 to 70\u2009km2) in\nthe basin of the Syuryuktyakh River. The results of this analysis indicate a\ntendency towards an area decrease in the Bolshaya Momskaya aufeis in recent\nyears, while no reduction in Syuryuktyakh River aufeis area was observed. The combined digital database of the aufeis is available at\nhttps:\/\/doi.org\/10.1594\/PANGAEA.891036.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":133789879,"openaccessinfo":{"externalids":{"MAG":"2922836931","ACL":null,"DOI":"10.5194\/ESSD-11-409-2019","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Several car manufacturers have proposed an alternative mode of auto transport called the low-speed private travel mode (LSPTM). It is a small single-seat electric vehicle that can run at speeds of around 5\u201320 km\/h. Further, it is regarded as a tool to improve the mobility of pedestrians and encourage the use of public transport. The aim of this study was to estimate how the mobility of pedestrians will be improved and how the environment will be impacted by the introduction of this vehicle. At the outset, a stated preference survey of the modal choices is conducted to ascertain the users' preference for the LSPTM to walking based on the actual trips of the respondents measured using the probe person survey system. To evaluate how traveler's activities will be expanded by the LSPTM, a joint logit model was proposed to predict the destination and mode choices of travelers travelling from a train station in the central area of Kobe to their destinations with parameters estimated by the stated preference survey of the modal choices. Based on the model, it was concluded that the size of the area where half the number of people visit increased by 2.6 times after introducing the LSPTM at a fare of 50 yen. This can encourage people to use trains and the LSPTM instead of cars, which can cause the total reduction of the emissions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153723623,"openaccessinfo":{"externalids":{"MAG":"2008093185","ACL":null,"DOI":"10.1080\/15568318.2013.710124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Experiments showed that minnows, Phoxinus phoxinus, sympatric with pike, Esox lucius, responded more vigorously to alarm substance than minnows from a population with no experience of pike predation in the wild. Minnows from the pike-sympatric (Dorset) population were more likely to hide and less likely to risk feeding than their pike-allopatric (Gwynedd) counterparts. The reaction to alarm substance in the pike-sympatric population was further increased when it was presented along with the visual stimulus of a 'stalking' model pike. When the Dorset minnows experienced both alarm substance and the pike model together they reduced their inspection behaviour to a level below that of the Gwynedd minnows. Minnows from the Gwynedd (pike-allopatric) population displayed increased levels of shoaling in the treatments in which alarm substance was used.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":85047804,"openaccessinfo":{"externalids":{"MAG":"2055075189","ACL":null,"DOI":"10.1111\/J.1095-8649.1988.TB05410.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper proposes a variable frequency zero-voltage-switching (ZVS) digital controlled boost-flyback converter (BFC) to achieve high efficiency and high step-up conversion. With no auxiliary switch introduced, ZVS of the MOSFETs can be achieved and reverse-recovery of diode eliminated naturally by operating the converter in boundary-conduction-mode. With the proposed control, both soft-switching and high efficiency are achieved in a wide load range. To achieve higher step-up ratio, lower voltage and current ripple in both input and output and lower current stress of the switches, a two-channel interleaved parallel-input\/series-output BFC is presented. The operation principle and control strategy is analyzed in detail and verified with a 230W 30V to 380V prototype.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":24923588,"openaccessinfo":{"externalids":{"MAG":"2116437689","ACL":null,"DOI":"10.1109\/ECCE.2011.6064309","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An idealised model is used to examine the tropospheric response to sudden stratospheric warmings (SSWs), by imposing transient stratospheric momentum torques tailored to mimic the wave-forcing impulse associated with spontaneously-occurring SSWs. Such an approach enables us to examine both the \u223c2-3-week forcing stage of an SSW during which there is anomalous stratospheric wave-activity convergence, as well as the recovery stage during which the wave forcing abates and the stratosphere radiatively recovers over 2-3 months. It is argued that applying a torque is better suited than a heating perturbation for examining the response to SSWs, due to the meridional circulation that is induced to maintain thermal-wind balance (i.e., the 'Eliassen adjustment'); an easterly torque yields downwelling at high latitudes and equatorward flow below, similar to the wave-induced circulation that occurs during spontaneously-occurring SSWs, whereas a heating perturbation yields qualitatively opposite behavior and thus cannot capture the initial SSW evolution. During the forcing stage, the meridional circulation in response to an impulse comparable to the model's internal variability is able to penetrate down to the surface and drive easterly-wind anomalies via Coriolis torques acting on the anomalous equatorward flow. During the recovery stage, after which the tropospheric flow has already responded, the meridional circulation associated with the stratosphere's radiative recovery provides the persistent stratospheric forcing that drives the high-latitude easterly anomalies, which is then augmented by synoptic-wave feedbacks that drive and amplify the annular-mode response. In comparison, planetary waves are found to play a relatively small role.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":244646890,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1175\/jas-d-21-0237.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The structure and catalytic activity of the oxygen electrode determine the overall electrochemical performance of lithium-oxygen (Li-O2) batteries. Here, a three-dimensional (3D) porous interconnected network structure combined with ultrathin MoS2 nanosheets with homogeneously dispersed CNTs (MoS2\/CNTs) was synthesized via a one-step hydrothermal reaction. The 3D interconnected architecture can efficiently promote the diffusion of O2 and Li ions as well as impregnation of electrolyte and provide more abundant storage space for the accommodation of discharge products, while the incorporation of uniformly dispersed CNTs improves the electronic conductivity and maintains the integrity of the cathode structure. Therefore, the Li-O2 battery based on MoS2\/CNTs achieves improved performance with the low overpotentials (discharge\/charge overpotentials of approximately 0.29 and 1.05 V), a high discharge specific capacity of 6904 mA h g-1 at a rate of 200 mA g-1, and excellent cycling stability (132 cycles). Experimental studies reveal that the improved electrochemical performance can be ascribed to the synergistic advantages of electronic conductive CNTs and excellent catalytic activity of the MoS2 nanosheets. Moreover, the unique 3D interconnected network structure can effectively facilitate fast charge transfer kinetics and a facile mass transport pathway. These encouraging performances demonstrate the metal sulfide catalyst as a promising catalytic material of oxygen electrodes for Li-O2 batteries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206486338,"openaccessinfo":{"externalids":{"MAG":"2892087413","ACL":null,"DOI":"10.1021\/acsami.8b06912","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this letter, a low-return-loss printed log-periodic dipole antenna (PLPDA) fed by a coaxial cable is presented. The widths of dipole elements are optimized to increase the bandwidth. A study of coaxial cable position is included in order to improve the antenna behavior. The measured return loss is lower than -15 dB from 2.1 to 4.3 GHz. The measured gain varies between 6 and 7 dBi. The measurements, including input impedance, gain and radiation patterns, and simulations are in agreement.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":20396752,"openaccessinfo":{"externalids":{"MAG":"2016506159","ACL":null,"DOI":"10.1109\/LAWP.2014.2310057","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Spinal orthosis is a common conservative treatment for adolescent idiopathic scoliosis (AIS), and a large body of compelling evidence from systemic review studies strongly supports the use of spinal orthosis treatment in patients with this condition. To further improve our understanding of the available data, the aim of this study is to develop and propose a protocol for a scoping review of systematic reviews of studies that investigated the effectiveness of orthotic treatment in patients with AIS. Systematic synthesis and understanding of the data will improve the efficacy of spinal orthosis treatment in this patient population. Method and analysis Using the scoping review methodological framework proposed by Arksey and O'Malley in 2005, we developed and herewith propose a scoping review protocol to evaluate systematic reviews of studies that investigated the effectiveness of orthotic treatment in AIS. Our proposed scoping review proposal is briefly described, as follows. A search of seven online databases will be conducted to identify systematic reviews published in English language from 1 January 2000 to 31 December 2023, and grey literature and reference lists of included articles will also be searched. A two-stage screening process consisting of a title and abstract screening and a full-text review will be used to determine articles' eligibility. All eligible articles will be extracted, charted and evaluated using Assessing the MeaSurement Tool to Assess systematic Reviews Version 2 (AMSTAR-2) critical appraisal tool. The charted data will be quantitatively analysed and summarised, and qualitatively analysed using narrative synthesis. Ethics and dissemination No primary data will be collected; therefore, ethics approval is not required. Findings will be disseminated through national and international conferences and publication in a peer-reviewed journal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":265066642,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjopen-2023-078064","PubMedCentral":"10632824","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/13\/11\/e078064.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The objective general of this descriptive exploratory study, from quantitative boarding, was to evaluate the knowledge of the Recife population about the H ealth Surveillance . The intentional not probabilistic sample was composed by 220 persons with complete average education, from 18 to 65 years age, had answered a questionnaire July 2006. The data had been analyzed and organized in tables and figures, proceeding the discussion in accordance with literature. The results has demonstrated that the majority of the sample had from 18 to 25 years old, single, female gender, had complete average education, with one to three minimum wages, composed for students and residents at Casa Amarela district. As for H ealth Surveillance definition, 54% had known define it and 91% didn't have received any information about it. Amongst the described actions about H ealth Surveillance had been considered most important: fiscalization (74%), educative (37%) and the preventive (33%). So that the H ealth Surveillance actions are accomplished become necessary the health professional contribution next to community in give some information through educative actions. Descriptors : Sanitary monitoring; Prevention; Education; Health","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":224558609,"openaccessinfo":{"externalids":{"MAG":"1579468615","ACL":null,"DOI":"10.5205\/REUOL.376-8800-1-LE.0102200706","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"No effective treatment is currently available for neurodegenerative diseases, and existing pharmacotherapy is inconsistent with severe side effects. Cell replacement therapy is promising for neurodegenerative disease treatment, and the induction of neurons is an unmet need for such therapy. The present study investigated the potential of a combined medium composed of conditioned medium and eight small molecular compounds in reprogramming human foreskin fibroblasts (HFFs) into neurons. HFFs were cultured from foreskin and then induced by small molecules to generate neurons. The results demonstrated that the conditioned medium containing forskolin, RepSox, SP600125, CHIR99021, Go6983, Y-27632, IXS9 and I-BET151 effectively induced human fibroblasts to change into neurons in vitro. Following a 30-day induction, the cells exhibited neuronal properties as determined by morphological and phenotypical alterations. The induced cells exhibited expression of neuronal markers, including class III \u03b2-tubulin, microtubule-associated protein 2, vesicular glutamate transporter 1 and \u03b3-aminobutyric acid, accompanied by increased expression of neuronal transcription factors, including neuronal differentiation 1 and achaete-scute family bHLH transcription factor 1, and decreased expression levels of fibroblast-specific genes. Furthermore, these cells also exhibited electrophysiological properties of neurons. Notably, the course of cell morphological alterations demonstrated the differentiation of fibroblasts into neurons. The present study provided a novel combination of existing small molecular compounds that efficiently reprogramed human fibroblasts into neurons.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":222952261,"openaccessinfo":{"externalids":{"MAG":"3090664178","ACL":null,"DOI":"10.3892\/mmr.2020.11559","PubMedCentral":"7646904","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2020.11559\/download","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The effect of anesthetic induction and surgical incision on activated clotting time (ACT) was determined in patients undergoing vascular surgery. Patients undergoing carotid endarterectomy (CAE) (n = 50) and abdominal aortic aneurysm repair (AAA) (n = 45) were studied. Patients in the CAE group had cervical plexus block anesthesia, whereas patients in the AAA group had a combination of epidural and general anesthesia. The ACT was measured 1) before induction of anesthesia, 2) 5 min after induction, 3) 5 min after incision, 4) 5 min after heparinization, and 5) at the onset of skin closure. Heparin was reversed with protamine only if the ACT after revascularization was > 200 s. Reversal was considered adequate if the ACT was < 200 s and the surgeon felt that hemostasis was adequate. The ACT decreased by 12.26 +\/- 1.23 (mean +\/- SE) (P = 0.006) in the CAE group and by 12.47 +\/- 1.01 (P = 0.002) in the AAA group with induction of anesthesia. There was a further decrease of 5.06 +\/- 0.62 (P = 0.26) in the CAE group and 5.17 +\/- 0.83 (P = 0.22) in the AAA group with incision. There was a significant difference in ACT in both groups from postinduction and postincision to skin closure (higher at skin closure). No patient in either group required additional protamine or clotting factors post-operatively, or return to the operating room for excessive bleeding. This study demonstrates that anesthetic induction with cervical block or epidural\/general anesthesia decreases ACT.(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34975751,"openaccessinfo":{"externalids":{"MAG":"1983049457","ACL":null,"DOI":"10.1213\/00000539-199304000-00004","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.lww.com\/anesthesia-analgesia\/Abstract\/1993\/04000\/The_Effect_of_Epidural_General_and_Cervical_Plexus.4.aspx","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"ESCAPE is a free python package and framework for creating applications for simulating and fitting of X-ray and neutron scattering data with current support for specular reflectivity, polarized neutron reflectometry, high resolution X-ray diffraction, small angle scattering with future support for off-specular scattering from structured samples with complicated morphology. Utilizing current features of Jupyter project, it allows to create highly customized applications in the format of notebooks. These notebooks, being shared with other users, can be used directly or started as web applications with graphical user interface. This paper is a brief overview of the core and scattering packages providing description of the major features with code examples. The following features make ESCAPE different from other projects: independent from scattering applications core, which provides access to models building blocks like parameters, variables, functors, data objects, models and optimizers; support of arithmetic operations and algebraic expressions on parameters and functors, offering models with complex dependencies of parameters; math module with standard mathematical functors and special functors which perform numerical integration over variable or parameter, supplying customization of intensity model; simultaneous fit of several models, also for models with different dimensions. Check our web site https:\/\/escape-app.net\/ for further information.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":226237127,"openaccessinfo":{"externalids":{"MAG":"3095256377","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2011.01340"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Women's organizing as a subject of study privileges women's agency and encourages students to redefine themselves as political actors. It offers a unique opportunity to demonstrate the relevance of often inaccessible debates in feminist theory, for example, about fluid identities, feminism as process, and contextual analysis. This article explores four ways of examining women's organizing that provide entry points into theory: the disaggregation of women's organizing and feminist organizing; the emphasis on context and strategic relativism; the move from identity politics to strategic alliances; and the differentiation of international, global and transnational","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":216119246,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to examine the influence of video games, as a form of digital media, on the formation of a new kind of sport. eSports take place in virtual space and do not rely only on the physical being of the participant, as is the case with the traditional understanding of sport, but on the interaction between man and a computer. This paper deals with the discourse of a contemporary game, which takes place in virtual space, and which is, according to theorists, classified as an eSports. Given that sport involves participants who occupy the \"physical world\", while eSport participants are in the \"virtual world\", as well as the fact that eSports athletes always have to use the Human-Computer interface that connects their bodies to an electronic system, a key issue that the authors of this paper seek to answer relates to whether there can be an electronic sport, and whether computer mediated sports have similarities with the traditional understanding of sport?","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":158781281,"openaccessinfo":{"externalids":{"MAG":"2889648781","ACL":null,"DOI":"10.22190\/FUPES170614012B","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, sliding mode control (SMC) technique is used to control the speed of DC motor. The performance of the SMC is judged via MATLAB simulations using linear model of the DC motor and known disturbance. SMC is then compared with PI controller. The simulation result shows that the sliding mode controller (SMCr) is superior controller than PI for the speed control of DC motor. Since the SMC is robust in presence of disturbances, the desired speed is perfectly tracked. The problem of chattering, resulting from discontinuous controller, is handled by pseudo sliding with smooth control action.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13561337,"openaccessinfo":{"externalids":{"MAG":"2534492672","ACL":null,"DOI":"10.1109\/IPECON.2010.5696985","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Enteroviral RNA (EV-RNA) was detected in endomyocardial tissue by means of retrotranscription and polymerase chain reaction (RT-PCR) followed by slot-blot hybridization. The myocardial biopsy specimens studied were taken at the time of heart transplantation from 15 patients with dilated cardiomyopathy (DCM) and from 10 patients with ischemic cardiomyopathy (ICM). Specimens from 18 (72%) of the 25 patients were positive for EV-RNA, whereas no control specimens (myocardial specimens from 29 healthy organ donors and atrial specimens from 15 patients with acute myocardial infarction treated by anatomic bypass) yielded evidence of EV-RNA. The rates of EV-RNA detection for the two groups requiring heart transplantation did not differ significantly (66.7% vs. 80.0%; chi 2 test). Our findings support a link between enteroviral infection in both DCM and ICM and suggest a pathogenic role for the enteroviruses.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22885514,"openaccessinfo":{"externalids":{"MAG":"2046082647","ACL":null,"DOI":"10.1093\/CLINIDS\/21.5.1315","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The article considers the use of cloud technologies during distance learning. The implementation of the mechanism of distance learning in general secondary education in two areas is described: distance form as a separate form of education and the use of distance learning technologies in the organization of education in various forms (day, evening, correspondence, etc.). The software for the organization of distance learning of pupils and students is listed. Examples of development of own electronic educational materials for teaching mathematics and computer science are given.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233803308,"openaccessinfo":{"externalids":{"MAG":"3138813191","ACL":null,"DOI":"10.1088\/1742-6596\/1840\/1\/012054","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/1840\/1\/012054","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The authors, having had a case of deep pelvic phlebitis occurring in a young primiparous woman who was treated prophylactically against the occurrence of a pulmonary embolus by placing a clip on the inferior vena cava discuss: the etiology of the condition: the difficulties of the diagnosis. They point out the value of phlebo-cavography which is an essential investigation in which no more than 4 films are taken, because it is on this that the indication for surgery rests. They point out the value of anticoagulant treatment, especially that using Calciparine which permits the patient to lead a more or less normal life at home. As far as the surgical procedure is concerned, a median approach seems to them the best way to carry out the operation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33587986,"openaccessinfo":{"externalids":{"MAG":"2417192488","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Population observations of the brown planthopper and its predators were conducted at Kalitirto Agriculture Experimentation Station, Yogyakarta during 10 seasons from 1986\/1987 Planting Season up to 1991\/1992. Five rice varieties were planted under randomized completely block design consisted of one susceptible varieties (IR 36 and IR 64). No pesticides applied during the experimentation. The data showed that BPH populations were constantly low and under subeconomic condition. The BPH populations tend to decrease from first season to the following seasons. The populations of BPH were fully controlled by the population of predators complex. The total of predator populations always surpasses BPH population in every season. The ratio of predators and BPH's population were increasing as planting seasons went along. The level of BPH resistance of rice varieties do not affect the fluctuation of BPH population and the total predators and BPH populations ratio.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":130008851,"openaccessinfo":{"externalids":{"MAG":"2273979691","ACL":null,"DOI":"10.22146\/jpti.9303","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/jurnal.ugm.ac.id\/jpti\/article\/download\/9303\/6939","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Summary The experiments described demonstrated that in the young, growing rat orotic acid-6-C 14 was converted to DNA pyrimidines for 24 hours following the initial injection, and the radioactivity was retained in the DNA during the next 7 weeks, a period during which the liver weight increased about threefold. Partial hepatectomy 40 or 46 days after administration of orotic acid-6-C 14 to the young rats resulted in essentially no change in the radioactivity content of the DNA during a 5- or 21-day period of liver regeneration in 3 out of 4 animals. These data support the proposed concept of the relatively high biochemical stability of DNA and show that this is true in tissues with widely varying rates of mitotic activity. When partial hepatectomy was performed on growing or adult rats at sufficiently short intervals after administration of orotic acid-6-C 14 , a radioactive intermediate was mobilized which served as a precursor pool from which labeled DNA pyrimidine nucleotides were synthesized. After the initial lag period which followed the operation, an increase in the C 14 content of the DNA was observed. The radioactivity level in the acid-soluble fraction and in the nuclear RNA fraction decreased extensively during the first 13-hour interval, but during the period of DNA synthesis the C 14 content of these fractions remained constant. The total radioactivity in the cytoplasmic RNA fraction was more than adequate to account for the maintenance of the radioactivity in the acid-soluble fraction, which presumably provides the immediate precursors for the synthesis of DNA and RNA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40872493,"openaccessinfo":{"externalids":{"MAG":"2616279887","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We isolated a binding protein for inositol 1,3,4,5-tetrakisphosphate (InsP4) from detergent-solubilized mouse cerebellar membrane fractions by sequential column chromatographies. Partial amino acid sequencing of the purified sample revealed that the protein is essentially identical to rat synaptotagmin II, an integral membrane protein of synaptic vesicles. Immunoprecipitation experiment of [3H]InsP4 binding activity of the purified protein using polyclonal antibody against the C2A domain of rat synaptotagmin II also revealed that mouse synaptotagmin II is the InsP4 binding protein (IP4BP). Scatchard analysis of InsP4 binding to the IP4BP\/synaptotagmin indicates a single binding site with a Kd of 30 nM. The present finding that InsP4 binds strongly to synaptotagmin II suggests an important role for inositol polyphosphates in the regulation of neurotransmitter release.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44714974,"openaccessinfo":{"externalids":{"MAG":"2055014964","ACL":null,"DOI":"10.1006\/BBRC.1994.2770","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objective: This paper reports on how the clinical consultation in primary care is performed under the new premises of patients' daily self-reporting and self-generation of data. The aim was to explore and describe the structure, topic initiation and patients' contributions in follow-up consultations after eight weeks of self-reporting through a mobile phone-based hypertension self-management support system. Design: A qualitative, explorative study design was used, examining 20 audio- (n\u2009=\u200910) and video-recorded (n\u2009=\u200910) follow-up consultations in primary care hypertension management, through interaction analysis. Clinical trials registry: ClinicalTrials.gov NCT01510301. Setting: Four primary health care centers in Sweden. Subjects: Patients with hypertension (n\u2009=\u200920) and their health care professional (n\u2009=\u20097). Results: The consultations comprised three phases: opening, examination and closing. The most common topic was blood pressure (BP) put in relation to self-reported variables, for example, physical activity and stress. Topic initiation was distributed symmetrically between parties and BP talk was lifestyle-centered. The patients' contributed to the interpretation of BP values by connecting them to specific occasions, providing insights to the link between BP measurements and everyday life activities. Conclusion: Patients' contribution through interpretations of BP values to specific situations in their own lives brought on consultations where the patient as a person in context became salient. Further, the patients' and health care professionals' equal contribution during the consultations showed actively involved patients. The mobile phone-based self-management support system can thus be used to support patient involvement in consultations with a person-centered approach in primary care hypertension management Key points \u2003 The clinical consultation is important to provide opportunities for patients to gain understanding of factors affecting high blood pressure, and for health care professionals to motivate and promote changes in life-style. This study shows that self-reporting as base for follow-up consultations in primary care hypertension management can support patients and professionals to equal participation in clinical consultations. Self-reporting combined with increased patient\u2013health care professional interaction during follow-up consultations can support patients in understanding the blood pressure value in relation to their daily life. These findings implicate that the interactive mobile phone self-management support system has potential to support current transformations of patients as recipients of primary care, to being actively involved in their own health.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":3645403,"openaccessinfo":{"externalids":{"MAG":"2793604154","ACL":null,"DOI":"10.1080\/02813432.2018.1426144","PubMedCentral":"5901443","ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/02813432.2018.1426144?needAccess=true","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Pseudomonas species are opportunistically pathogenic to humans, yet closely related species are used in biotechnology applications. In order to screen for the pathogenic potential of strains considered for biotechnology applications, several Pseudomonas strains (P.aeruginosa (Pa), P.fluorescens (Pf), P.putida (Pp), P.stutzeri (Ps)) were compared using functional virulence and toxicity assays. Most Pa strains and Ps grew at temperatures between 28\u00b0C and 42\u00b0C. However, Pf and Pp strains were the most antibiotic resistant, with ciprofloxacin and colistin being the most effective of those tested. No strain was haemolytic on sheep blood agar. Almost all Pa, but not other test strains, produced a pyocyanin-like chromophore, and caused cytotoxicity towards cultured human HT29 cells. Murine endotracheal exposures indicated that the laboratory reference strain, PAO1, was most persistent in the lungs. Only Pa strains induced pro-inflammatory and inflammatory responses, as measured by elevated cytokines and pulmonary Gr-1 -positive cells. Serum amyloid A was elevated at \u2265 48 h post-exposure by only some Pa strains. No relationship was observed between strains and levels of peripheral leukocytes. The species designation or isolation source may not accurately reflect pathogenic potential, since the clinical strain Pa10752 was relatively nonvirulent, but the industrial strain Pa31480 showed comparable virulence to PAO1. Functional assays involving microbial growth, cytotoxicity and murine immunological responses may be most useful for identifying problematic Pseudomonas strains being considered for biotechnology applications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4924159,"openaccessinfo":{"externalids":{"MAG":"2181443383","ACL":null,"DOI":"10.1371\/journal.pone.0143604","PubMedCentral":"4664251","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0143604&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A theoretical discussion of the precipitin patterns obtained with cross-reacting systems, as studied by the Ouchterlony gel diffusion technique, is presented. The conditions that result in single or double spurs are described, and experimental examples are given.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":893208,"openaccessinfo":{"externalids":{"MAG":"1520855424","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Non-stationary loading of a mechanical system consisting of a hinged beam and additional support installed in the beam span was studied using a model of the beam deformation based on the Timoshenko hypothesis with considering rotatory inertia and shear. The system of partial differential equations describing the beam deformation was solved by expanding the unknown functions in the Fourier series with subsequent application of the integral Laplace transform. The additional support was assumed to be realistic rather than rigid. Thus it has linearly elastic, viscous, and inertial components. This means that the effect of a part of the support vibrating with the beam was considered such that their displacements coincide. The beam and additional support reaction were replaced by an unknown concentrated external force applied to the beam. This unknown reaction was assumed to be time-dependent. The time law was determined by solving the first kind of Volterra integral equation. The methodology of deriving the integral equation for the unknown reaction was explained. Analytic formulae and results of computations for specific numerical parameters were given. The impact of the mass value on the additional viscoelastic support reaction and the beam deflection at arbitrary points were determined. The research results of this paper can be helpful for engineers in designing multi-span bridges.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259810955,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21272\/jes.2023.10(1).d2","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"http:\/\/jes.sumdu.edu.ua\/wp-content\/uploads\/2023\/05\/jes_10_1_2023_D8-D14.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Dementia of the country due to the aging population of 59 thousand people has reached serious territory. To increase the number of future dementia doubled every 20 years until 2050, in 2020 about 84 thousand people, about 127 thousand people in 2030, 2050 are estimated at 271 thousand people. If you have a gas stove when using dementia patients at home, Voice Support breaker is required in a fire can automatically block the gas valve because of a risk. In this paper, we develop a gas-timer demented patients using S3F8S19 8bit processor to use the gas safely.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220455673,"openaccessinfo":{"externalids":{"MAG":"3022617460","ACL":null,"DOI":"10.17661\/JKIIECT.2015.8.6.551","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Development of biocompatible dental implants has attained significant impact in dental industry. In the present work, we report for the development of biocompatible nano-Yttria-stabilized Zirconia (YSZ) coatings on 316L stainless steel (316L SS) obtained by EPD process followed by sintering at air atmosphere. The surface morphology and electrochemical performance of nano-YSZ-coated 316L SS were investigated to evaluate its corrosion behavior in artificial saliva medium. The surface morphology and composition of the coatings were characterized by XRD, Raman, and FESEM with EDAX, respectively. The electrochemical performance of the uncoated metal and nano-YSZ-coated 316L SS samples were evaluated in artificial saliva medium using electrochemical techniques such as Open Circuit Potential \u2013 time measurement (OCP), Electrochemical Impedance Spectroscopy (EIS), and Cyclic Potentiodynamic Polarization (CPP). The nano-YSZ-coated 316L SS thin film possess significant electrochemical and biocompatibility properties compared to uncoated metal. Nano-YSZ-coated 316L SS (70 V, 5 min, 800 \u00b0C) acts as an active and also as a good barrier against corrosive ions and resists ions penetration from artificial saliva to the metal surface.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234169688,"openaccessinfo":{"externalids":{"MAG":"3119955942","ACL":null,"DOI":"10.1557\/s43578-020-00017-0","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Implantation of polymeric heart valves can solve the problems of existing valve substitutes \u2013 mechanical and biological. Objective : to comprehensively assess the hemocompatibility of styrene-isobutylene-styrene (SIBS) triblock copolymer, synthesized by controlled cationic polymerization in comparison with expanded polytetrafluoroethylene (ePTFE) used in clinical practice. Materials and methods . SIBS-based films were made by polymer solution casting method; in vitro biocompatibility assessment was performed using cell cultures, determining cell viability, cell adhesion and proliferation; tendency of materials to calcify was determined through in vitro accelerated calcification; i n vivo biocompatibility assessment was performed by subcutaneous implantation of rat samples; hemocompatibility was determined ex vivo by assessing the degree of hemolysis, aggregation, and platelet adhesion. Results . The molecular weight of synthesized polymer was 33,000 g\/mol with a polydispersity index of 1.3. When studying cell adhesion, no significant differences (p = 0.20) between the properties of the SIBS polymer (588 cells\/mm 2 ) and the properties of culture plastics (732 cells\/mm 2 ) were discovered. Cell adhesion for the ePTFE material was 212 cells\/mm 2 . Percentage of dead cells on SIBS and ePTFE samples was 4.40 and 4.72% (p = 0.93), respectively, for culture plastic \u2013 1.16% (p < 0.05). Cell proliferation on the ePTFE surface (0.10%) was significantly lower (p < 0.05) than for the same parameters for SIBS and culture plastic (62.04 and 44.00%). Implantation results (60 days) showed the formation of fibrous capsules with average thicknesses of 42 \u03bcm (ePTFE) and 58 \u03bcm (SIBS). Calcium content in the explanted samples was 0.39 mg\/g (SIBS), 1.25 mg\/g (ePTFE) and 93.79 mg\/g (GA-xenopericardium) (p < 0.05). Hemolysis level of red blood cells after contact with SIBS was 0.35%, ePTFE \u2013 0.40%, which is below positive control (p < 0.05). Maximum platelet aggregation of intact platelet-rich blood plasma was 8.60%, in contact with SIBS polymer \u2013 18.11%, with ePTFE \u2013 22.74%. Conclusion . In terms of hemocompatibility properties, the investigated SIBS polymer is not inferior to ePTFE and can be used as a basis for development of polymeric prosthetic heart valves.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":216202572,"openaccessinfo":{"externalids":{"MAG":"3003203732","ACL":null,"DOI":"10.15825\/1995-1191-2019-4-67-80","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.15825\/1995-1191-2019-4-67-80","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Although exercise is a central therapeutic modality in insulin-dependent diabetic patients, its prescription and expected effects have remained far less precise than the concurrent modalities of insulin and diet. To quantify the potential benefit of exercise on meal glycemic excursions, eight insulin-dependent diabetic subjects were studied on two separate days during breakfast and lunch, with and without 45 min of moderate exercise, starting 30 min after breakfast. All other variables were kept constant, including their usual insulin doses, which were given subcutaneously in the abdomen. Fasting glycemias were brought to comparable levels by overnight insulin infusion (rest day: 110 \u00b1 9 mg\/dl; exercise day: 105 \u00b1 9 mg\/dl). Postprandial exercise reduced peak glycemia for breakfast (270 \u00b1 22 versus 203 \u00b1 22 mg\/dl) and lunch (270 \u00b1 16 versus 170 \u00b1 20 mg\/dl, P < 0.05) for the group as a whole on rest day and exercise day, respectively. Three types of individual responses were seen. Five subjects showed an improved glycemic excursion with exercise during both breakfast and lunch. In two subjects only the lunch response was significantly improved. One subject showed no effect of exercise. The failure to demonstrate a lowering of glycemia with breakfast appears to be related to the persistent use of fatderived fuels in these subjects. This is suggested by a lower respiratory quotient (RQ), and elevated free fatty acid and 3-hydroxybutyrate concentrations. Plasma \"free\" insulin and glucagon concentrations could not account for these observations. Thus, the majority of subjects showed improved glucoregulation related to exercise performed postprandially. If adequately insulinized, conventionally treated diabetic individuals can benefit from strategically timed exercise.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":28703096,"openaccessinfo":{"externalids":{"MAG":"2122148351","ACL":null,"DOI":"10.2337\/diacare.5.4.364","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1RF in vegetations, organs, and blood, despite being inoculated in greater numbers. These results indicate that gls24 is important in the pathogenesis of enterococcal endocarditis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20876142,"openaccessinfo":{"externalids":{"MAG":"2132178937","ACL":null,"DOI":"10.1128\/IAI.73.11.7772-7774.2005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traditional medicines have been playing significant role in livestock health care management since long especially in remote area. This paper is based on a field survey conducted to collect information for curing different ailments utilized by local people and tribals in the Hamirpur district, Himachal Pradesh. Total 541 households were interviewed involved as informants with fully prepared questionnaires; proper interaction along with group discussion. Information were collected from the selected sites regarding way to cure different ailments of animals which was further analyzed for the authenticity of data through different statistical quantitative indices. We found total 121 plant species belonging to 61 families that have been documented to be of common use for curing 78 different types of livestock. Total ailments were categorized into fifteen major categories based on the body organ systems of livestock. The highest number of ethno-medicinal plants were recorded from family Fabaceae followed by Asteraceae and other families. Leaves were the most commonly used part of the plant for the preparation of ethno-medicinal medicines followed by other plant parts. Achyranthes aspera, Acorus calamus, Pogostemon benghalensis are the most important plants used to cure different ailments on the basis of use value index. On the basis of Informant Consensus factor (FIC), diseases related to digestive system, reproductive system, respiratory and fever were considered as major ailments in the livestock. In conclusion, we found in this study that most of the plants are widely used to cure different ailments as reported previously by different workers. However, on the first hand, many new findings to cure different ailments of livestock have been found during this survey indicating need for conducting more studies to get valuable information from the local community which are not documented yet. It was also found that indigenous people have excellent information with respect to ethnoecological aspect. There is an urgent need to study and document the traditional uses before they are disappeared from the society or community and further study must be integrated with qualitative and quantatitative data to assess importance of plants for ethno-veterinery purposes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263688245,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The influence of quantity of wagon groups in a set of multi-group train and breaks in accumulation of train sets on fluctuations of the value of parameter of train set accumulation is considered.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":113441844,"openaccessinfo":{"externalids":{"MAG":"2519455813","ACL":null,"DOI":"10.15802\/STP2008\/15449","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Yaoling tungsten deposit is a typical wolframite quartz vein\u2010type tungsten deposit in the South China metallogenic province. The wolframite\u2010bearing quartz veins mainly occur in Cambrian to Ordovician host rocks or in Mesozoic granitic rocks and are controlled by the west\u2010north\u2010west trending extensional faults. The ore mineralization mainly comprises wolframite and variable amounts of molybdenite, chalcopyrite, pyrite, fluorite, and tourmaline. Hydrothermal alteration is well developed at the Yaoling tungsten deposit, including greisenization, silicification, fluoritization, and tourmalinization. Three types of primary\/pseudosecondary fluid inclusions have been identified in vein quartz, which is intimately intergrown with wolframite. These include two\u2010phase liquid\u2010rich aqueous inclusions (type I), two\u2010 or three\u2010phase CO2\u2010rich inclusions (type II), and type III daughter mineral\u2010bearing multiphase high\u2010salinity aqueous inclusions. Microthermometric measurements reveal consistent moderate homogenization temperatures (peak values from 200 to 280\u00b0C), and low to high salinities (1.3\u201339 wt % NaCl equiv.) for the type I, type II, and type III inclusions, where the CO2\u2010rich type II inclusions display trace amounts of CH4 and N2. The ore\u2010forming fluids are far more saline than those of other tungsten deposits reported in South China. The estimated maximum trapping pressure of the ore\u2010forming fluids is about 1230\u20131760 bar, corresponding to a lithostatic depth of 4.0\u20135.8 km. The \u03b4DH2O isotopic compositions of the inclusion fluid ranges from \u221266.7 to \u221247.8\u2030, with \u03b418OH2O values between 1.63 and 4.17\u2030, \u03b413C values of \u22126.5\u20130.8\u2030, and \u03b434S values between \u22121.98 and 1.92\u2030, with an average of \u22120.07\u2030. The stable isotope data imply that the ore\u2010forming fluids of the Yaoling tungsten deposit were mainly derived from crustal magmatic fluids with some involvement of meteoric water. Fluid immiscibility and fluid\u2013rock interaction are thought to have been the main mechanisms for tungsten precipitation at Yaoling.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":135151393,"openaccessinfo":{"externalids":{"MAG":"2889934979","ACL":null,"DOI":"10.1111\/rge.12188","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/rge.12188","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The Copyright Act of 1976 provides that works\u2014including scholarship\u2014written \nwithin the scope of employment belong to employers. But copyright law and actual \npractices widely diverge. The academic community generally allows librarians to \nclaim ownership of their writing, even when that ignores copyright law. Mr. Hellyer \nsupports copyright ownership by librarians, and calls for the law and common practices \nto be harmonized.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":3}},"corpusid":147911399,"openaccessinfo":{"externalids":{"MAG":"2381297489","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose Older adults should be routinely screened for sarcopenia, which threatens healthy, independent aging. The most popular screening tool is the SARC-F questionnaire. As its sensitivity is unsatisfactory, two modified versions of the questionnaire have been published: SARC-CalF (including calf circumference as an additional item) and SARC-F+EBM (assessing additionally age and Body Mass Index). The diagnostic performance of the three versions of the questionnaire has not been compared. The analysis aimed to assess the diagnostic value of SARC-F, SARC-CalF, and SARC-F+EBM questionnaires, and to compare their psychometric properties against two reference standards of sarcopenia diagnosis, ie, EWGSOP1 and modified EWGSOP2 criteria. Materials and Methods We performed the sensitivity\/specificity analysis and compared the overall diagnostic accuracy of SARC-F, SARC-CalF (31cm) (cut-off point 31 cm for both genders), SARC-CalF (33\/34cm) (cut-off points: 33 cm for women and 34 cm for men), and SARC-F+EBM in 115 community-dwelling volunteers aged \u2265 65 yrs from Poland. Results Depending on the version of the SARC-F questionnaire used, from 10.4% [SARC-CalF (31cm)] to 33.0% (SARC-F+EBM) were identified as having an increased risk of sarcopenia. Sarcopenia was identified in 17.4% by the EWGSOP1 criteria and in 13.9% by the modified EWGSOP2 criteria. With respect to the two reference standards used, the sensitivity of SARC-F, SARC-CalF (31cm), SARC-CalF (33\/34cm), and SARC-F+EBM ranged 30.0\u201337.5%, 35.0\u201337.5%, 60.0\u201362.5%, 55.0% (the same value for both reference standards), respectively. The specificity ranged 85.3\u201385.9%, 93.9\u201394.7%, 88.4\u201386.9%, 70.7\u201371.6%, respectively. The AUC of SARC-F, SARC-CalF (31cm), SARC-CalF (33\/34cm) and SARC-F+EBM ranged 0.644\u20130.693, 0.737\u20130.783, 0.767\u20130.804, 0.714\u20130.715, respectively. Conclusion The modified versions of SARC-F have better diagnostic performance as compared to the original questionnaire. Since an ideal screening tool should have reasonably high sensitivity and specificity, and an AUC value above 0.7, the SARC-CalF (33\/34cm) seems to be the best screening tool for sarcopenia in community-dwelling older adults.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":218675081,"openaccessinfo":{"externalids":{"MAG":"3019930135","ACL":null,"DOI":"10.2147\/CIA.S250508","PubMedCentral":"7196242","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Middle Pennsylvanian Minturn Formation and the Pennsylvanian and Permian Sangre de Cristo Formation of the northern Sangre de Cristo Range form a 4,000-m (13,000-ft) thick, progradational sequence of fan-delta and alluvial-fan deposits. This sequence was deposited along the western margin of the central Colorado trough during faulting and uplift of the late Paleozoic Uncompahgre highland of the Ancestral Rocky Mountains. The Minturn Formation is composed mostly of sandstone and shale deposited by fan deltas that prograded into the central Colorado trough. The Minturn of the northern Sangre de Cristo Range is divisible into (1) a turbidite-bearing facies, (2) a limestone-bearing facies, and (3) a red-bed facies. The turbidite-bearing facies is interpreted as deposits of fan deltas that prograded onto the sea bottom below wave base. The limestone-bearing facies is interpreted as deposits of fan deltas that prograded onto a shallow sea bottom above wave base. Turbidites and shallow-marine limestones, although they make up only a minor part of the Minturn Formation, are mutually exclusive deposits that serve to distinguish the two facies. In the limestone-bearing facies, sandstones containing deltaic fore ets overlie thin shallow-marine limestones and are considered diagnostic of that facies. Both facies contain thick intervals of sandstone and shale interpreted as deltaic and alluvial deposits. Where it onlaps the Uncompahgre highland, the lower part of the Minturn Formation contains quartzose and arkosic red beds of probable alluvial origin. The continental Sangre de Cristo Formation conformably overlies the Minturn Formation basinward, but it unconformably overlies Minturn Formation and Precambrian basement near the Uncompahgre highland. The Sangre de Cristo Formation contains (1) a sandstone facies deposited on the distal surfaces of alluvial fans, and (2) a conglomerate facies (Crestone Conglomerate Member) deposited on the proximal surfaces of alluvial fans. The sandstone facies consists of fining-upward cycles of red conglomeratic sandstone and siltstone interpreted as braided-stream deposits. The conglomerate facies consists of poorly sorted conglomerates interpreted as debris-flow and mudflow deposits, and sorted conglomerate and sandstone interpreted as streamflow and sheetflow deposits. End_of_Article - Last_Page 854------------","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128596959,"openaccessinfo":{"externalids":{"MAG":"2112381605","ACL":null,"DOI":"10.1306\/03B5B916-16D1-11D7-8645000102C1865D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper choose self-adaptive filtering method to smooth noise for the crop leaf image. This method adjusts the output of filter according to the local variance of the image, and store the edge, high-frequency detail of crop leaf image. The experiment indicates that it's very convenient to calculate the filter parameters, and filter the image, that is no better than linear filters with needing more computing time.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10210015,"openaccessinfo":{"externalids":{"MAG":"2070634280","ACL":null,"DOI":"10.1109\/ICACC.2010.5487124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Effect of mixing with a controlled pore glass (CPG) on the stability of aspirin was studied under conditions of various relative humidities (RH), pore diameters of CPG and concentrations of aspirin. The crystallinity changes of aspirin in the mixtures with CPG170 or CPG3000 were also studied using the powder X-ray diffraction method and microscopy. The amorphous aspirin in the CPG mixtures showed an extremely fast decomposition rate, and a high rate was obtained when the pore diameter of the CPGs were less than 300 A. In the mixtures of small pore diameter CPG, the decomposition rate constants were greater at a lower RH. These results can be explained in terms of the catalytic effect of free silanol groups on the surface of the CPG.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100924452,"openaccessinfo":{"externalids":{"MAG":"2320647604","ACL":null,"DOI":"10.1248\/CPB.39.1027","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is shown that Witten's positive-energy proof remains valid under considerably weakened boundary conditions for the Cauchy data at spatial infinity, as recently formulated by Chrusciel (1985).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120019496,"openaccessinfo":{"externalids":{"MAG":"1965855912","ACL":null,"DOI":"10.1088\/0264-9381\/3\/6\/003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Two isomeric achiral bent-core liquid crystals involving a 4-cyanoresorcinol core and containing a carbosilane unit as nanosegregating segment were synthesized and were shown to form ferroelectric liquid-crystalline phases. Inversion of the direction of one of the COO groups in these molecules leads to a distinct distribution of the electrostatic potential along the surface of the molecule and to a strong change of the molecular dipole moments. Thus, a distinct degree of segregation of the carbosilane units and consequent modification of the phase structure and coherence length of polar order result. For the compound with larger dipole moment (CN1) segregation of the carbosilane units is suppressed, and this compound forms paraelectric SmA and SmC phases; polar order is only achieved after transition to a new LC phase, namely, the ferroelectric leaning phase (SmCLs PS ) with the unique feature that tilt direction and polar direction coincide. The isomeric compound CN2 with a smaller dipole moment forms separate layers of the carbosilane groups and shows a randomized polar SmA phase (SmAPAR ) and ferroelectric polydomain SmCs PS phases with orthogonal combination of tilt and polar direction and much higher polarizations. Thus, surprisingly, the compound with the smaller molecular dipole moment shows increased polar order in the LC phases. Besides ferroelectricity, mirror-symmetry breaking with formation of a conglomerate of macroscopic chiral domains was observed in one of the SmC phases of CN1. These investigations contribute to the general understanding of the development of polar order and chirality in soft matter.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22989341,"openaccessinfo":{"externalids":{"MAG":"2345513308","ACL":null,"DOI":"10.1002\/chem.201503901","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study was performed to examine the increasing biological activities of both nerve growth factor induction and anti-aging activity of gastrodia (Gastrodia elata) with fermentation process. Antioxidant activities, taken in the fermenting, were investigated to verify utility value of gastrodia for functional food and cosmetics. Fermented gastrodia extracts showed higher antioxidant activities than dried gastrodia extracts. During the routine check of all the practical use potential as functional food, inhibition effect of angiotensin converting enzyme (ACE) and xanthine oxidase (XOase) was tested among water extracted dried gastrodia (WEDG), water extracted fermented gastrodia (WEFG), 70% ethanol extracted dried gastrodia (EEDG) and 70% ethanol extracted fermented gastrodia (EEFG). DPPH was shown as WEDG = 64.14 \u00b1 0.89%, WEFG = 66.21 \u00b1 1.03%, EEDG = 82.25 \u00b1 0.52%, and EEFG = 82.36 \u00b1 2.37%. ABTS was shown as WEDG = 54.15 \u00b1 1.37%, WEFG = 60.24 \u00b1 2.25%, EEDG = 59.18 \u00b1 1.86%, and EEFG = 77.17 \u00b1 4.23%. Therefore, ACE activity was dramatically inhibited by EERG while there was no difference of XOase inhibition between EEFG and EERG. Nerve growth factor (NGF) activity was measured and indicated about 40% increased neurite growth effect. To conclude, biologically active compounds of gastrodia were increased by fermentation process. It seems to be that ferment gastrodia enhance the use ranges from functional food to fuctional cosmetics, and to all processing industry.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":84035349,"openaccessinfo":{"externalids":{"MAG":"1877980425","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We continue the program of structural differential geometry that begins with the notion of a tangent category, an axiomatization of structural aspects of the tangent functor on the category of smooth manifolds. In classical geometry, having an affine structure on a manifold is equivalent to having a flat torsion-free connection on its tangent bundle. This equivalence allows us to define a category of affine objects associated to a tangent category and we show that the resulting category is also a tangent category, as are several related categories. As a consequence of some of these ideas we also give two new characterizations of flat torsion-free connections. We also consider 2-categorical structure associated to the category of tangent categories and demonstrate that assignment of the tangent category of affine objects to a tangent category induces a 2-comonad. Finally, following work of Jubin, we consider monads and comonads on the category of affine objects associated to a tangent category. We show that there is a rich theory of monads and comonads in this setting as well as various distributive laws and mixed distributive laws relating these monads and comonads. Even in the category of smooth manifolds, several of these results are new or fill in gaps in the existing literature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":159035977,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": Streptomycin sensitivity of 112 Leptospira strains isolated from domestic and wild animals was studied. Independent of the isolation period and nature the strains proved to be highly sensitive to the antiobiotic (MIC 0.1 to 0.5 gamma\/ml). On the example of a clone strain of Leptospira it was shown with a fluctuation test that streptomycin resistance occurred spontaneously. Frequency of the streptomycin resistant mutations was determined for 5 clone strains of L. interrogans. It was 10-9 to 10-7 per a Leptospira.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88537997,"openaccessinfo":{"externalids":{"MAG":"2438413858","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Radiation and cetuximab are therapeutics used in the management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these modalities, development of both intrinsic and acquired resistance is an emerging problem in the management of this disease. Thus, identifying and targeting the molecules that drive resistance to radiation or cetuximab is essential for improving efficacy of treatment approaches. Previously, we identified AXL as a logical molecular target in HNSCC and indicated that it may play a pivotal role in resistance to radiation and cetuximab. In our current study, we advanced these early findings into pre-clinical models using patient-derived xenografts (PDXs). We found bemcentinib which is a small molecule inhibitor AXL, can enhance therapy in radiation- or cetuximab- resistant PDXs. Next, we investigated the molecular mechanisms of how AXL signaling which leads to resistance. Three tyrosine residues of AXL (Y779, Y821, Y866) were mutated and examined for their sensitivity to cetuximab and\/or radiation. Overexpression of AXL wild type rendered radiation- or cetuximab- sensitive HNSCC line resistant, but cell lines overexpressing AXL-Y821F retained their sensitivity. Advancing this line of investigation in vivo indicated that tumors overexpressing AXL were resistant to cetuximab whereas tumors harboring the Y821 mutation were sensitive. These results demonstrated that signals emanating from Y821 may be critical for cetuximab- and radiation- resistant pathways. Further, reverse phase protein array (RPPA) was employed to analyze the proteomic architecture of signaling pathways in these cell lines. The c-Abl expression level was higher in HN30-AXL compared to HN30-vector or HN30-AXL-Y821F mutant. Further, immunoprecipitation indicated that c-Abl and AXL were highly associated in HN30-AXL cells, while this association was absent in vector or AXL-Y821F mutant cells. Finally, targeting c-Abl, using imatinib, in cetuximab resistant PDXs led to complete tumor regression and further, up to 3 months after cessation of treatment, these tumors exhibited no recurrence. Collectively, the studies presented herein suggest that tyrosine 821 of AXL mediates resistance to cetuximab by activation of c-Abl in HNSCC and targeting both EGFR and c-Abl leads to a robust anti-tumor response. These results provide rationale for the clinical targeting of c-Abl to enhance the therapeutic modalities used in treating HNSCC. Citation Format: Nellie K McDaniel, Mari Iida, Kwangok P Nickel, Tamara S Rodems, Adam D Swick, Prashanth J Prabakaran, Jaimee C Eckers-Kubatzke, Noah B Welke, Carlene Kranjac, Alison E Schulz, Randy J Kimple, Ravi Salgia, Deric L Wheeler. AXL mediates cetuximab resistance through tyrosine 821 and activation of c-Abl kinase in head and neck cancer [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr A128. doi:10.1158\/1535-7163.TARG-19-A128","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":213744015,"openaccessinfo":{"externalids":{"MAG":"2993510022","ACL":null,"DOI":"10.1158\/1535-7163.TARG-19-A128","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An effective way of providing error resilience with a relatively small reduction in compression ratio is multiple description coding (MDC). All multiple description codes to date assume the existence of multiple independent \"on-off\" channels between the transmitter and receiver. Each link is either broken in which case the symbols or packets are completely lost, or it functions properly, in which case symbols are received free of errors. This channel model is appropriate for wireline networks, such as the Internet, but it may not be applicable to other commonly used channels such as wireless channels. We replace the parallel independent on-off channel model with wireless channel models such as a Rayleigh fading model. We also communicate using multiple transmit and receive antennas over the channel. Furthermore, we use digital bandpass modulation to transmit the source symbols.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":18256419,"openaccessinfo":{"externalids":{"MAG":"1855277410","ACL":null,"DOI":"10.1109\/GLOCOM.2001.966291","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mathematical modeling and real-time system simulation for liquefied natural gas (LNG) ship steam turbine propulsion system are significant not only to development of LNG engine room simulator, system optimized control, fault diagnosis but also to increasing the economics, safety, reliability. Through the analysis of mechanism, using the method of modular modeling and lumped parameters modeling, a real-time modularized mathematical model for LNG ship steam turbine propulsion system has been developed based on the principle of fluid dynamics, heat transfer and thermo-dynamics. The steam turbine propulsion system of LNG ship built by Shanghai HuDong-Zhonghua shipyard has been taken as an example to system simulation purpose. Simulation studies were conducted and the results show that the built model has satisfied static precision and dynamic characteristics and the accuracy meets the simulation requirements. The model has been utilized in LNG Ship engine room simulation system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":17703603,"openaccessinfo":{"externalids":{"MAG":"2087268298","ACL":null,"DOI":"10.1109\/SoCPaR.2011.6089159","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Information models found a wide application in advanced control systems, decision making systems, play a fundamental role in any activity concerned with the signal processing process. In the paper, information identification models in variable structure control systems are considered; a methodology of the synthesis of a variable structure control system is presented, as well issues of the stability of a model built by use of the associative search are considered, in the aspect of the spectrum analysis of the multi-scale wavelet expansion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44688116,"openaccessinfo":{"externalids":{"MAG":"2437861440","ACL":null,"DOI":"10.1109\/SIBCON.2016.7491757","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider the energy savings that can be obtained by employing network coding instead of plain routing in wireless multiple unicast problems. We establish lower bounds on the benefit of network coding, defined as the maximum of the ratio of the minimum energy required by routing and network coding solutions, where the maximum is over all configurations. It is shown that if coding and routing solutions are using the same transmission range, the benefit in d-dimensional networks is at least 2d\/ \u221ad . Moreover, it is shown that if the transmission range can be optimized for routing and coding individually, the benefit in 2-dimensional networks is at least 3. Our results imply that codes following a decode-and-recombine strategy are not always optimal regarding energy efficiency.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39694028,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The regional localisation of the alpha globin (HBA) complex on the short arm of chromosome 16 was investigated by in situ hybridisation, Southern blot analysis, and linkage analysis using the fragile site at 16p12.3 (FRA16A) and translocation breakpoints within band 16p13.1. HBA was found to be distal to the two translocation breakpoints within band 16p13.1 and not closely linked to FRA16A. In situ hybridisation to the distal portion of the fragment on metaphase chromosomes expressing the fragile site and the observation of considerable recombination between FRA16A and HBA supports a localisation for HBA closer to the telomere than to FRA16A, at 16p13.2----pter.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19481842,"openaccessinfo":{"externalids":{"MAG":"1976382064","ACL":null,"DOI":"10.1136\/jmg.24.12.761","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jmg.bmj.com\/content\/jmedgenet\/24\/12\/761.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We study several new invariants associated to a holomorphic projective structure on a Riemann surface of finite analytic type: the Lyapunov exponent of its holonomy which is of probabilistic\/dynamical nature and was introduced in our previous work; the degree which measures the asymptotic covering rate of the developing map; and a family of harmonic measures on the Riemann sphere, previously introduced by Hussenot. We show that the degree and the Lyapunov exponent are related by a simple formula and give estimates for the Hausdorff dimension of the harmonic measures in terms of the Lyapunov exponent. In accordance with the famous \"Sullivan dictionary\", this leads to a description of the space of such projective structures that is reminiscent of that of the space of polynomials in holomorphic dynamics.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":117128095,"openaccessinfo":{"externalids":{"MAG":"1485552853","ACL":null,"DOI":"10.1215\/00127094-2017-0012","PubMedCentral":null,"ArXiv":"1308.0541"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1308.0541","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Large power systems are nowadays mostly operated as interconnected subsystems, each not always based on identical legislative, historical and geographical regulations. Within this\n interconnection, each power system is controlled by its respective control authority, forming a decentralized structure. In this paper methods are presented, decomposing a central optimal\n power flow (OPF) problem into distributed subproblems. These subproblems are then solved in an iterative way, independently but coordinated. Based on an available decomposition method, an\n improved decomposition procedure is proposed. With the new method, the convergence rate is considerably enhanced and no parameter tuning is required. Simulation results are presented,\n applying the procedures to an illustrative 9-bus as well as to the IEEE 39-bus system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":113472935,"openaccessinfo":{"externalids":{"MAG":"2600973235","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thirteen analgesic drugs, four of them at two dose levels, four analgesics in combination with antagonist or neuroleptic agents, and saline have been evaluated simultaneously in the relief of postoperative pain. The method of assessment was designed to favour drugs which provided freedom from pain with minimum depression of consciousness. Only levorphanol 2 mg proved significantly superior to pethidine 100 mg, which was used as the standard reference drug. Oxycodone 10 mg, pentazocine 20 mg, and the morphine 10 mg and cyclizine 50 mg combination were the most successful of the remaining drugs. None of the drug combinations was significantly better than the analgesic drug given alone.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23463792,"openaccessinfo":{"externalids":{"MAG":"2059364399","ACL":null,"DOI":"10.1136\/bmj.3.5769.287","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.bmj.com\/content\/bmj\/3\/5769\/287.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We know that some physical phenomena can be derived from a more basic substratum. Heat is a manifestation of the kinetic energy of atoms. Atoms are more fundamental than the laws of thermodynamics, but atomic physics in turn is derived from the interactions of more primitive components. Is fundamentality then a relative concept with no absolute bottom, or is there a fundament of physical law which is not derived from anything deeper? Does physics perhaps circle back on itself in recursive fashion? \"Fundamental\" is an adjective to describe a level of reality that is not derived from anything else. Fundamental laws are not in any way accidental or arbitrary. They must be as they are, because they could not be any other way. If such a level of reality exists, then how can it be explained? Do we just have to accept it as axiomatic? Does it emerge out of nothing? These questions seem unanswerable but we must not accept defeat so quickly. The universe exists, so there must be answers. Why would those answers be incomprehensible to us? I sketch some answers choosing information, events, symmetry, quantisation and stories as fundamental concepts.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":85536947,"openaccessinfo":{"externalids":{"MAG":"2901356815","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Temperature fluctuation occurs while mixing of hot and cold fluids in a T-junction due to incomplete thermal mixing. This temperature fluctuation can produce thermal fatigue at the weld area of the T-junction. The present study aims to numerically investigate the thermal mixing characteristics of hot and cold fluids in a T-junction. The realizable k-\u03b5 turbulence model is used with natural gas as the working fluid. Temperature distribution, mixing quality, and intensity of temperature fluctuation are evaluated and compared along with the mixing outlet. The inlet temperature difference and branch to main pipe flowrate ratio have a direct influence on thermal mixing. The higher temperature difference can reduce the thermal mixing performance. Thermal mixing increases with the increase of branch to main pipe flowrate. The intensity of temperature fluctuation is found within a short distance from the intersecting point of the two inlets. With the increase of distance along with the mixing outlet, the frequency of temperature fluctuation decreases, and thermal mixing increases.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":241298180,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.37934\/cfdl.13.9.2841","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.37934\/cfdl.13.9.2841","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Epstein-Barr virus (EBV) is an important human pathogenic gammaherpesvirus with carcinogenic potential. The EBV transcriptome has previously been analyzed using both Illumina-based short read- and Pacific Biosciences RS II-based long-read sequencing technologies. In this work, we use the Oxford Nanopore Technologies MinION platform for the characterization of the EBV transcriptomic architecture. Both amplified and non-amplified cDNA sequencings were applied for the generation of transcription reads, including both oligo-d(T) and random oligonucleotide-primed reverse transcription. EBV transcripts are identified and annotated using the LoRTIA software suite developed in our laboratory. This study detected novel short genes (embedded into longer host genes) containing 5'-truncated in-frame open reading frames (ORFs), which might encode N-terminally truncated proteins. We also detected a number of novel non-coding RNAs and transcript length isoforms encoded by the same genes but differing in their start and\/or end sites. This study also reports the discovery of novel splice isoforms, many of which may represent altered coding potential, and of novel Ori-associated RNA molecules. Additionally, novel mono- and polycistronic, as well as complex transcripts have been uncovered. An intricate meshwork of transcriptional overlaps has also been revealed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":243251811,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-109629\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-109629\/v1.pdf?c=1605905427000","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"What did Napoleon Bonaparte mean to the British people? This engaging book reconstructs the role that the French leader played in the British political, cultural, and religious imagination in the early nineteenth century. Denounced by many as a tyrant or monster, Napoleon nevertheless had sympathizers in Britain. Stuart Semmel explores the ways in which the British used Napoleon to think about their own history, identity, and destiny. Many attacked Napoleon but worried that the British national character might not be adequate to the task of defeating him. Others, radicals and reformers, used Napoleon's example to criticize the British constitution. Semmel mines a wide array of sources--ranging from political pamphlets and astrological almanacs to sonnets by canonical Romantic poets--to reveal surprising corners of late Hanoverian politics and culture.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152496394,"openaccessinfo":{"externalids":{"MAG":"578091867","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT A study of anaerobic sediments below cyanobacterial mats of a low-salinity meltwater pond called Orange Pond on the McMurdo Ice Shelf at temperatures simulating those in the summer season (<5\u00b0C) revealed that both sulfate reduction and methane production were important terminal anaerobic processes. Addition of [2-14C]acetate to sediment samples resulted in the passage of label mainly to CO2. Acetate addition (0 to 27 mM) had little effect on methanogenesis (a 1.1-fold increase), and while the rate of acetate dissimilation was greater than the rate of methane production (6.4 nmol cm\u22123 h\u22121compared to 2.5 to 6 nmol cm\u22123 h\u22121), the portion of methane production attributed to acetate cleavage was <2%. Substantial increases in the methane production rate were observed with H2 (2.4-fold), and H2 uptake was totally accounted for by methane production under physiological conditions. Formate also stimulated methane production (twofold), presumably through H2 release mediated through hydrogen lyase. Addition of sulfate up to 50-fold the natural levels in the sediment (interstitial concentration, \u223c0.3 mM) did not substantially inhibit methanogenesis, but the process was inhibited by 50-fold chloride (36 mM). No net rate of methane oxidation was observed when sediments were incubated anaerobically, and denitrification rates were substantially lower than rates for sulfate reduction and methanogenesis. The results indicate that carbon flow from acetate is coupled mainly to sulfate reduction and that methane is largely generated from H2 and CO2 where chloride, but not sulfate, has a modulating role. Rates of methanogenesis at in situ temperatures were four- to fivefold less than maximal rates found at 20\u00b0C.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":948308,"openaccessinfo":{"externalids":{"MAG":"1776797291","ACL":null,"DOI":"10.1128\/AEM.65.12.5493-5499.1999","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, the conventional ZVS PWM boost converter is improved to minimize the switching loss of the auxiliary switch using the minimum number of components. To reduce the switching loss and EMI noise, the saturable core and the parallel capacitor across the clamp diode (D2) are used in the auxiliary switching network. Using this technique, soft-switching for the auxiliary switch is guaranteed at wide line and load ranges. Since the active switches are turned on and off softly, the switching losses are reduced significantly and higher efficiency of the system is achieved. This paper proposes an improved ZVS PWM Boost PFP. A prototype of a 200 kHz 1 kW system was implemented to show the improved performance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110995798,"openaccessinfo":{"externalids":{"MAG":"2171840879","ACL":null,"DOI":"10.1109\/APEC.2001.911669","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The opportunity recently came to me to visit Brazil under peculiarly favorable conditions from the standpoint of dermatologic study. Dr. de Mello of Syracuse, who originally came from Brazil, recently returned to his native country for a visit, preceding me by a few weeks. This enabled him to make plans for me to give some lectures before medical societies and to meet the leading dermatologists of Brazil. One of my objects was to observe and photograph cases of the Brazilian type of cutaneous leishmaniasis, which I hope to report on later. It may be of interest to recall the fact that Brazil is larger than the United States and greater in population and area than all the rest of South America. It is composed of twenty states and the federal district of Rio de Janeiro, the latter being also the name of a state. Of the four cities which I","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":57130487,"openaccessinfo":{"externalids":{"MAG":"2001990665","ACL":null,"DOI":"10.1001\/ARCHDERM.1929.01440050031002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was carried out with the aim of using three processes of soil washing, electrofenton and biological leaching method in order to rehabilitate the soil contaminated with lead and phenanthrene around the south Tehran oil refinery. The variables examined in this study are the amount of soil (500, 1000, 1500, 2000 mg), the ratio of surfactant to soil (7.50, 15, 22.50, 30, 37.50 L\/Kg), time (6, 12, 18, 24, 30 hours), lead concentration (25, 50, 37.50, 62.50 mg\/kg) and phenanthrene concentration (50, 100, 15, 200 mg\/kg). In the washing process, the highest percentage of lead removal is 78.23% at the contact surface of 2000 mg, the surfactant-to-soil ratio is 30 ml\/kg, the time is 24 hours, the concentration of lead and phenanthrene is 50 and 100 mg\/kg and the highest removal percentage of phenanthrene (73.4%) in the soil amount of 1000 mg, the ratio of soil to surfactant equal to 30 liters\/kg, in 12 hours, the amount of lead and phenanthrene were obtained equal to 25 and 100 mg\/kg. Next, the soil was placed in a discontinuous reactor with graphene electrode as cathode and iron electrode as anode to conduct electrofenton. The investigated variables are solution pH (2, 4, 6, 8, 10), reaction time (12.5, 25, 37.5, 50, 62.5 minutes), hydrogen peroxide concentration (0.5, 1, 1.5, 2, 2.5 w\/w) and direct electric current (0.75, 1.5, 2.25, 3, 3.75 A). The results indicated that in the electrofenton pH process, hydrogen peroxide concentration and then voltage had the greatest effect and time had the least effect on the removal of lead and phenanthrene. In this way, the highest percentage of lead removal was 85.4% at pH equal to 8, hydrogen peroxide concentration equal to 2 W\/W, current equal to 1.5 A and 50 minutes and the highest percentage of phenanthrene removal (85.9%) at pH equal to 6, hydrogen peroxide concentration equal to 1.5W\/W, current equal to 2.25 A and 37.5 minutes were obtained. In the biological leaching method, the purified strain (Pseudomonas aeruginosa) was isolated from the soils around the refinery. Environmental pH (3, 5, 7, 9, 11), pollutant to biomass ratio (7.50, 15, 22.50, 30, 37.5 mg\/g) and retention time (1, 2, 3, 4, 5 hour) were considered as main variables. pH was the most important parameter influencing the removal of lead and phenanthrene from soil in biological method. The highest percentage of lead removal with 85.4% was obtained at pH equal to 8, hydrogen peroxide concentration equal to 2W\/W, current 1.5 A and 50 minutes time. In the case of phenanthrene, the highest removal percentage of phenanthrene (85.9%) was measured at pH equal to 6, hydrogen peroxide concentration of 1.5 W\/W, current of 2.25 A and in 37.5 minutes. Comparing the results of the third stage of soil cleaning with the control sample without preparation steps with the removal percentage of 0.67 and 0.42 for lead and phenanthrene, shows the effect of the soil preparation process in order to improve the ability of bacteria to function and shows that by combining three methods of washing, electrofenton and biologic, it is possible to rehabilitate contaminated soils resistant to biological decomposition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":263815608,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.30955\/gnj.005316","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journal.gnest.org\/sites\/default\/files\/Submissions\/gnest_05316\/gnest_05316_draft.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"With the development of power system the complexity is increased by many folds at present time. The 21st century power users and consumers expectation on power quality is very high. At the same time consumers of nonlinear loads such as power converters etc also increasing. Therefore the online behavior of the power supply characteristics is changing with the unexpected users. The equipments which are present with the system were coming continuously under stress to overcome such unexpected fluctuations of power characteristics. Therefore a continuous monitoring and controlling process for improvement of these situations became a necessity. Thus the power researchers are continuously under pressure to develop new model of power conditioning equipments for on-line power monitoring. The power quality monitoring system incorporates some aspects of power qualities such as voltage sag, voltage swell, phase shift, flickers, harmonics, frequency etc. The power quality monitoring systems are so far designed and implemented in online may have improved individually the above compensations, but none has proved to be ideally covered in a single power equipment compensation system. This paper presents the design and development of UPQC system to monitor above compensations such as power quality surges, voltage sag, voltage swell, harmonics, frequency and reactive power of a power system. A simulation of the system in MATLAB and results on it are presented.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":22465415,"openaccessinfo":{"externalids":{"MAG":"2054069052","ACL":null,"DOI":"10.1109\/INDCON.2012.6420743","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This process occurs via the ingression of an actomyosin ring that assembles in anaphase and pulls in the overlying plasma membrane as it constricts. Mechanistic studies have uncovered different pathways that regulate the assembly and position of the ring in mammalian cells, but the majority of these studies were done using HeLa cells with overexpressed transgenes, and the relative requirement for these mechanisms among the majority of cell types is not known. Here, we used CRISPR\/Cas9 gene editing to endogenously tag cytokinesis proteins, anillin, Ect2 and RhoA, as well as other cellular components, with fluorescent proteins. These tools enabled the visualization of cytokinesis by live imaging to quantitatively study these proteins at endogenous levels. As a proof-of-concept, tagging anillin in multiple mammalian cell lines revealed cytokinetic diversity, which will be useful for studies of how mechanisms controlling cytokinesis vary among cell types. We also successfully tagged multiple cellular components in the same cell line, demonstrating the versatility of these tagging tools.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247476567,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2022.03.14.484313","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1101\/2022.03.14.484313","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various pathological and inflammatory conditions, representing potential therapeutic targets. Prostaglandins (PTGs) and leukotrienes (LTs) are eicosanoids derived from arachidonic acid and related polyunsaturated fatty acids that participate in both normal homeostasis and inflammatory conditions. These bioactive lipid mediators are synthesized through two major multistep enzymatic pathways: PTGs by cyclooxygenase and LTs by 5-lipoxygenase. The main physiological effects of PTGs include vasodilation and vascular leakage (PTGE2); mast cell maturation, eosinophil recruitment, and allergic responses (PTGD2); vascular and respiratory smooth muscle contraction (PTGF2), and inhibition of platelet aggregation (PTGI2). LTB4 is mainly involved in neutrophil recruitment, vascular leakage, and epithelial barrier function, whereas cysteinyl LTs (CysLTs) (LTC4, LTD4, and LTE4) induce bronchoconstriction and neutrophil extravasation, and also participate in vascular leakage. PTGs and LTs exert their biological functions by binding to cognate receptors, which belong to the seven transmembrane, G protein-coupled receptor superfamily. SNPs in genes encoding these receptors may influence their functionality and have a role in disease susceptibility and drug treatment response. In this review we summarize SNPs in PTGs and LTs receptors and their relevance in human diseases. We also provide information on gene expression. Finally, we speculate on future directions for this topic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5455517,"openaccessinfo":{"externalids":{"MAG":"2521999389","ACL":null,"DOI":"10.3389\/fphar.2016.00316","PubMedCentral":"5030812","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2016.00316\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The hepatorenal syndrome [HRS]is a reversible functional acute renal failure secondary to intense renal cortical vasoconstriction in a patient with liver disease. It affects around 40% of patients with cirrhosis and ascites1. The exact cause of the syndrome is not well understood. The state of liver dysfunction [Child-Pugh score] does not predict the occurrence of the disease. Genetic factors play no important role except as risk for liver disease and there is no sex difference. Patients with HRS characteristically have increased cardiac output, low arterial pressure, and reduced systemic vascular resistance. Diagnosis of HRS is one of exclusion. The definitive treatment is liver transplant. Nevertheless, a lot of work was done on medical therapy with promising results. Sudan Journal of Medical Sciences Vol. 1(1) 2006: 59-61","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":72637999,"openaccessinfo":{"externalids":{"MAG":"2056200178","ACL":null,"DOI":"10.4314\/SJMS.V1I1.38443","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study identifies individual's motivations for volunteering to work at a Foundation in Paraiba, Brazil. It does not draw any conclusions regarding those motivations; for instance, the reasons for volunteer turnover, or the effective benefits that prompt individuals to volunteer in the Brazilian context. This is a longitudinal study, with data collection at two separate times, over two years. The goals of the study are to reduce differences of the motivations of volunteers in Brazil, and to support the managers in general who interact with volunteers through the recruitment of new applications. The data collection was based on a model that is validated in the national context, and was based on the main factors: altruistic values, social justice, affiliation, learning opportunity, and selfish values. The data were analyzed using descriptive statistical methods, ANOVA, the Student's t Test for independent samples, and correlations (bivariate). Altruistic motivations, the search for social justice, and learning opportunity are indicated were the aspects most frequently mentioned in the surveys. Significantly, an inverse relation occurs with the variables \"age\" and \"selfish profile\".","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249269315,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the usefulness of weed species in semi-arid areas of Mpwapwa District, Central Tanzania. As crop production systems in these areas are often impacted by unreliable rainfall, frequent drought, and low soil fertility, smallholder farmers have developed different strategies to ensure that their livelihood is sustained. One of these strategies is the use of weed species for different purposes. A field inventory conducted in 36 smallholder farmers' fields in the case study area during the 2006\/2007 cropping season identified a total of 63 weed species from 26 plant families. Usefulness of identified weed species in these areas was determined through focus group discussions with community representatives. Out of 63 weed species presented during these meetings, nine species were indicated as the most useful weed species in those communities. Pairwise ranking indicated Cleome hirta (mhirile) to be the most important species. Others in order of importance were: Amaranthus graecizans (mfwene), Bidens lineoriloba (mphangalale), Bidens pilosa (mpwimbwiza), Dactyloctenium aegyptium (ihungo), Launaea cornuta (sunga), Heteropogon contortus (sigi), Tragus berteronianus (namata), and Trichodesma zeylanicum (nyawaje). These species were mentioned to be mainly used as vegetable, medicine, food, fodder, and thatching materials. Weed species used as food have been mentioned to help people during period of droughts. Medicinal weed species were also mentioned to be useful in the area. Ailments mentioned that can be treated by selected species include malaria, painful menstruation, extended menstruation cycle, and stomach ache in men (ngiri). These species are also said to reduce blood flow during circumcision. The majority of women in the area were the ones involved in harvesting, preparation, and selling the useful weed species in the visited markets. The main conclusion drawn from this study is that, although weed species are regarded as unwanted plant species in crop production, they still play a vital role in food security and for the health of different people in marginal areas.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":126568898,"openaccessinfo":{"externalids":{"MAG":"181513717","ACL":null,"DOI":"10.17660\/ACTAHORTIC.2009.806.46","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ROMK (Kir1.1; Kcnj1) gene is believed to encode the apical small conductance K+channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD). Loss-of-function mutations in the human ROMK gene cause Bartter's syndrome with renal Na+ wasting, consistent with the role of this channel in apical K+ recycling in the TAL that is crucial for NaCl reabsorption. However, the mechanism of renal K+ wasting and hypokalemia that develop in individuals with ROMK Bartter's syndrome is not apparent given the proposed loss of the collecting duct SK channel. Thus, we generated a colony of ROMK null mice with \u223c25% survival to adulthood that provides a good model for ROMK Bartter's syndrome. The remaining 75% of null mice die in less than 14 days after birth. The surviving ROMK null mice have normal gross renal morphology with no evidence of significant hydronephrosis, whereas non-surviving null mice exhibit marked hydronephrosis. ROMK protein expression was absent in TAL and CCD from null mice but exhibited normal abundance and localization in wild-type littermates. ROMK null mice were polyuric and natriuretic with an elevated hematocrit consistent with mild extracellular volume depletion. SK channel activity in TAL and CCD was assessed by patch clamp analysis in ROMK wild-type ROMK(+\/+), heterozygous ROMK(+\/\u2212), and null ROMK(\u2212\/\u2212) mice. In 313 patches with successful seals from the three ROMK genotypes, SK channel activity in ROMK (+\/+ and +\/\u2212) exhibited normal single channel kinetics. The expression frequencies are as follows: 67 (TAL) and 58% (CCD) in ROMK(+\/+); about half that of the wild-type in ROMK(+\/\u2212), being 38 (TAL) and 25% (CCD); absent in both TAL or CCD in ROMK(\u2212\/\u2212) between 2 and 5 weeks in 15 mice (61 and 66 patches, respectively). The absence of SK channel activity in ROMK null mice demonstrates that ROMK is essential for functional expression of SK channels in both TAL and CCD. Despite loss of ROMK expression, the normokalemic null mice exhibited significantly increased kaliuresis, indicating alternative mechanisms for K+absorption\/secretion in the nephron.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25085334,"openaccessinfo":{"externalids":{"MAG":"2015344956","ACL":null,"DOI":"10.1074\/jbc.M206644200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background. The aim of this study was to investigate myofibroblast (MF) density in a broad spectrum of odontogenic cysts and tumors and the relation between the density of MFs and the clinical behavior of these lesions. Methods. A total of 105 cases of odontogenic lesions, including unicystic ameloblastoma (UAM), solid ameloblastoma (SA), odontogenic keratocyst (OKC), dentigerous cyst (DC), radicular cyst (RC) (15 for each category), and odontogenic myxoma (OM), adenomatoid odontogenic tumor (AOT), calcifying odontogenic cyst (COC) (10 for each category), were immunohistochemically stained with anti-\u03b1-smooth muscle actin antibody. The mean percentage of positive cells in 10 high-power fields was considered as MF density for each case. Results. A statistically significant difference was observed in the mean scores between the study groups (P < 0.001). The intensity of MFs was significantly higher in odontogenic tumors compared to odontogenic cysts (P < 0.001). There was no statistically significant difference between odontogenic tumors, except between UAM and OM (P = 0.041). The difference between OKC and odontogenic tumors was not statistically significant (P > 0.05). The number of MFs was significantly higher in OKC and lower in COC compared to other odontogenic cysts (P = 0.007 and P = 0.045, respectively). Conclusion. The results of the present study suggest a role for MFs in the aggressive behavior of odontogenic lesions. MFs may represent an important target of therapy, especially for aggressive odontogenic lesions. Our findings support the classification of OKC in the category of odontogenic tumors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15902899,"openaccessinfo":{"externalids":{"MAG":"2300118860","ACL":null,"DOI":"10.15171\/joddd.2016.006","PubMedCentral":"4831610","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.15171\/joddd.2016.006","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We report the performance of HF calorimeter and some details about the PMT window hit events. The new 4-anode PMTs will be installed during the 2013 shutdown period. We have developed HF GFlash, a very fast simulation of electromagnetic showers using parameterizations of the profiles in Hadronic Forward Calorimeter. HF GFlash has good agreement to 7 TeV Collision Data and previous Test Beam results. In addition to good agreement with Data and previous Test Beam results, HF GFlash can simulate about 10000 times faster than Geant4.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110577310,"openaccessinfo":{"externalids":{"MAG":"2164654789","ACL":null,"DOI":"10.1051\/EPJCONF\/20134918005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cell Biology\nCilia contain a well-ordered array of microtubule doublets along their length. A longstanding question in cilium structure and function is why the microtubule arrangement in cilia is so complex. Stepanek and Pigino developed a time-resolved correlative fluorescence and three-dimensional electron microscopy method to show that the doublets provide directionality to intraflagellar transport. One microtubule in the pair moves cargoes up to the ciliary tip. Meanwhile, the other microtubule moves cargoes back to the cell body. These results explain why the axoneme is built out of microtubule doublets and suggest a mechanistic picture of how the logistics of bidirectional intraflagellar transport are regulated.\n\nScience , this issue p. [721][1]\n\n [1]: \/lookup\/doi\/10.1126\/science.aaf4594","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":87809420,"openaccessinfo":{"externalids":{"MAG":"2347161366","ACL":null,"DOI":"10.1126\/SCIENCE.352.6286.668-I","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction The Buschke Lowenstein tumour is an extremely rare, slow-growing, locally destructive, cauliflower-like mass, also known as giant condyloma acuminata. Case Report: We report a case of a 42 year old male who presented to the department of surgery with perineal tumour since two years. The mass was painless initially but later became painful. On local examination, the ano perineal region of the patient was completely occupied by a cauliflower like tumour with multiple fistulae. After histopathological confirmation, the tumour was removed surgically, as it was resistant to medical treatment. Radical surgery was attempted. The tumour was found to be very vascular and deeply infiltrating. Wide local resection of the perianal tissue was performed Discussion Histopathology of BLT shows blunt-shaped masses of tumour project deeply into the dermis and contiguous structures. The tumour cells have little evidence of atypia and are not found inside blood vessels or lymphatics. Individual keratinocytes may show keratinization, but no horn pearls are seen. Lymphohistiocytic inflammation is usually present. Conclusion Troublesome recurrences of BLT occur frequently and a propensity for infection and fistula formation is common. Regardless of the size and origin of BLTs, gaining early control of the disease using wide, radical surgical excision provides the best overall rate of survival.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":70528681,"openaccessinfo":{"externalids":{"MAG":"1971476913","ACL":null,"DOI":"10.1136\/SEXTRANS-2013-051184.0270","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nHuman papillomavirus (HPV) vaccination has shown high efficacy against anal HPV infection and lesions in clinical trials, and the HPV prevalence and type distribution in anal precancers and cancer predict a high preventable potential for HPV vaccination. However, the real-world effectiveness of HPV vaccination against anal high-grade lesions and cancer is yet to be shown.\n\n\nMETHODS\nWe investigated HPV vaccine effectiveness against anal high-grade squamous intraepithelial lesion or worse (HSIL+) in a nationwide cohort including all Danish women aged (17-32 years) during October 2006-December 2021 (N\u2009=\u2009968,881). HPV vaccinations and first occurrence of anal HSIL+ were retrieved from nationwide registries. Women were considered vaccinated after first dose and classified by age at vaccination. Using Cox regression, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for anal HSIL+ according to vaccination status.\n\n\nRESULTS\nDuring follow-up, the number of incident histological anal HSIL+ cases was 37 in unvaccinated women, and <5 and 26 in women vaccinated at\u2009<\u200917 years and 17-32 years of age, respectively. The overall number of cancers was <5. Compared with unvaccinated women, the risk of histological anal HSIL+ was reduced for women vaccinated at age <17 years (HR\u2009=\u20090.30, 95% CI: 0.10-0.87). For women vaccinated at 17-32 years, the hazard rate of anal HSIL+ was 1.21 (95% CI: 0.73-2.03).\n\n\nCONCLUSION\nThis is the first study to demonstrate that HPV vaccination at a younger age is associated with substantially reduced risk of anal HSIL+ in the general population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262042463,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/jnci\/djad189","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Film is a medium that is able to represent reality in a wide-screen frame. Garuda di Dadaku film is a film that tries to present the reality of a sense of nationalism citizens through sports facilities and then try to bring it back through a movie. This study aims to find representation sports nationalism in the film Garuda di Dadaku. The theory used in this study is the representation theory of Stuart Hall. About how the production of meaning of concepts that exist in our minds through language. This study used a qualitative approach with a semiotic analysis of Roland Barthes who tried to uncover the meaning behind a sign, to investigate and examine the signs of the Garuda di Dadaku film. The results of this study indicate that the Garuda di Dadaku film shows a representation of nationalism is marked by several things including: unity (unity), freedom (liberty), equality (equality), personality (individuality), achievement (performance), which can be viewed through the signs such as dialogue, costumes, performances, or images that exist in the film. Nationalism tries to be represented through sport, in this case is football. Nationalism is also trying to be displayed in the form of children, especially urban children, and nationalism can also give birth racism. This is because nationalism is expressed in the wrong way, through love of exaggeration. Suggested to the producers for more movies to make movies with the theme of nationalism is felt still less than the themes of the other films.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54965709,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Leptospirosis is a zoonotic disease which becomes a health problem in several regions in Indonesia. In 2020, there were 1,170 cases of Leptospirosis with a CFR of 9.1% spread across 8 Provinces. This study aims to determine the environmental factors that influence the incidence of leptospirosis in Indonesia. The method applied here was literature review through the Google Scholar, Pubmed and GARUDA databases which examined the environmental factors of leptospirosis in Indonesia. This was a case control study with cross sectional design with a range of published journal publications from 2016\u20132022. The number of samples in this study were 11 articles. The results of the study indicated that there were several environmental risk factors for the incidence of leptospirosis in Indonesia, namely the presence of standing water around the house, the poor maintained condition of ditches, the existence of trash bins that did not meet the requirements, the distance between the house and the open drain and the presence of rats inside and outside the house, and 7 articles found the presence of rats as the most dominant influential factor. Communities in leptospirosis endemic areas are expected to be more concerned with the condition of the surrounding environment and always maintain the cleanliness of their houses to prevent rats breeding as a medium for the spread of leptospirosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261945350,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper proposes a noninvasive method for estimating the dynamic characteristics of arterial walls using pulse waves measured in various parts of the body by a foil-type pressure sensor. The sensor not only has high sensitivity and flexibility but also features the ability to continuously measure the alternating-current component of pulse waves. These capabilities make it suitable for estimating the dynamic characteristics of arterial walls. In this paper, a foil-type pressure sensor was employed to measure pulse waves based on the tonometry approach, and a method of estimating changes in arterial viscoelastic indices was proposed based on the measured pulse waves and photoplethysmograms. In order to accurately measure blood pressure, first, we examined suitable mechanical forces to the sensor, and found that values of 5-25[N] yielded the best performance. We then estimated the arterial viscoelastic indices of a radial artery and a dorsal pedis artery when mechanical pain stimuli were applied to the subjects. The results suggested that the estimated indices can be used to quantitatively assess vascular response caused by sympathicotonia. We thus concluded that the proposed method enabled noninvasive measurement of pulse waves in the dorsal pedis artery and estimation of arterial viscoelastic indices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":62125790,"openaccessinfo":{"externalids":{"MAG":"2094541831","ACL":null,"DOI":"10.1541\/IEEJEISS.131.1518","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We develop Grothendieck duality for projective Deligne-Mumford stacks, in particular we prove the existence of a dualizing complex for a morphism from a projective stack to a scheme and for a proper representable morphism of algebraic stacks. In the first case we explicitly compute the dualizing complex and prove that Serre duality holds for smooth projective stacks in its usual form. We prove also that a projective stack has dualizing sheaf if and only if it is Cohen-Macaulay, it has a dualizing sheaf that is an invertible sheaf if and only if it is Gorenstein and for local complete intersections we explicitly compute the invertible sheaf. As an application of this general machinery we compute the dualizing sheaf of a nodal projective curve.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":17612427,"openaccessinfo":{"externalids":{"MAG":"1489770165","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Independent directors are valuable because they do not suffer from the agency costs \nthat afflict executive directors. Independent directors also operate at an informational \ndisadvantage compared with executive directors, which makes it hard for them to carry \nout their duties of advising and monitoring, and thus affects their value. I test the \nimpact of the cost of information acquisition on board structure by exploiting a change in \nan accounting standard that forced US public firms to be more transparent about their \noperations. Analysts' forecasts subsequently became more precise and less dispersed \nfor the firms more affected, suggesting that the cost of information acquisition has \ndecreased. Consistent with independent directors' greater value, I document an increase \nin appointed independent directors. Cross-sectional tests suggest that independent \ndirectors are more valuable because of their improved monitoring capacity, as opposed to \ntheir advising capacity. Robustness tests using alternative data sources do not confirm \nthe findings. Implications are discussed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219349732,"openaccessinfo":{"externalids":{"MAG":"3082380878","ACL":null,"DOI":"10.2139\/ssrn.3559505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The adoption of Information Technology (IT) and Information Systems (IS) represents significant financial investments, with alternative perspectives to the evaluation domain coming from both the public and private sectors.As a result of increasing IT\/IS budgets and their growing significance within the development of an organizational infrastructure, the evaluation and performance measurement of new technology remains a perennial issue for management. This book offers a refreshing and updated insight into the social fabric and technical dimensions of IT\/IS evaluation together with insights into approaches used to measure the impact of information systems on its stakeholders. In doing so, it describes the portfolio of appraisal techniques that support the justification of IT\/IS investments. Evaluating Information Systems explores the concept of evaluation as an evolutionary and dynamic process that takes into account the ability of enterprise technologies to integrate information systems within and between organisations. In particular, when set against a backdrop of organisational learning. It examines the changing portfolio of benefits, costs and risks associated with the adoption and diffusion of technology in today's global marketplace. Finally approaches to impact assessment through performance management and benchmarking is discussed. * A unique reference work and examination of the IS evaluation 'life-cycle' * An holistic treatment of the subject beyond the normal prescriptive 'investment appraisal' approaches that reflects recent developments in the field* Essential text for students on business information systems courses and an insightful resource for professionals engaged in justifying IT\/IS expenditure","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":107265287,"openaccessinfo":{"externalids":{"MAG":"102182605","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To explore and react to their environment, living micro-swimmers have developed sophisticated strategies for locomotion - in particular, motility with multiple gaits. To understand the physical principles associated with such a behavioural variability,synthetic model systems capable of mimicking it are needed. Here, we demonstrate bimodal gait switching in autophoretic droplet swimmers. This minimal experimental system is isotropic at rest, a symmetry that can be spontaneously broken due to the nonlinear coupling between hydrodynamic and chemical fields, inducing a variety of flow patterns that lead to different propulsive modes. We report a dynamical transition from quasi-ballistic to bimodal chaotic motion, controlled by the viscosity of the swimming medium. By simultaneous visualisation of the chemical and hydrodynamic fields, supported quantitatively by an advection-diffusion model, we show that higher hydrodynamic modes become excitable with increasing viscosity, while the recurrent mode-switching is driven by the droplet's interaction with self-generated chemical gradients. We further demonstrate that this gradient interaction results in anomalous diffusive swimming akin to self-avoiding spatial exploration strategies observed in nature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":222008374,"openaccessinfo":{"externalids":{"MAG":"3134048029","ACL":null,"DOI":"10.1103\/PHYSREVX.11.011043","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since the early 1970s, pharmaceutical biochemists have sought to exploit the scientific findings that were uncovered when they studied the basis for the function and mode of action of fibric acid derivatives. In the early 1970s, little was known of peroxisome proliferator-activated receptors (PPARs), even in concept. Since then, however, the development of bioactive small molecules in medicinal science has resulted in tools developed to be inserted into the PPAR-binding domain, which has resulted in the recognition of literally thousands of possible biological effects of binding configurations. In diabetes care, the first of the marketed agents from these discoveries and developments was introduced in 1996. It was potent and did its job well. However, the use of this early form of thiazolidinedione sometimes, although rarely, led to fulminant liver failure, and ultimately the drug was removed from the market. Subsequent thiazolidinediones have been developed, and 2 have been relatively successful. However, they are not without their problems. This article describes the history of the development of these drugs, identifies the valuable attributes that they possess, and gives a clear rationale as to why a quest for a \"safer\" PPAR agonist is still being sought.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23403319,"openaccessinfo":{"externalids":{"MAG":"2021502433","ACL":null,"DOI":"10.3945\/ajcn.2009.28449D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The anti-hepatitis B virus activity and hepatoprotective activity of a liquid fermentation broth of Ganoderma lucidum were investigated. The cultured broth was supplemented with aqueous extract of Radix Sophorae flavescentis, a kind of Chinese herbal medicine. Our results indicated that the cultured broth had effects of anti-hepatitis B virus activity in vitro and protected mice from liver damage in vivo. Our results also indicated that the co-fermentation broth of Ganoderma lucidum in the presence of aqueous extract of Radix Sophorae flavescentis has better medicinal effects than simply mixing these two ingredients together, suggesting a potential novel way to prepare Chinese herbal mixtures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40389521,"openaccessinfo":{"externalids":{"MAG":"2171138375","ACL":null,"DOI":"10.1142\/S0192415X06003874","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since chemotherapeutic agents used to control microbial fish diseases have led to resistance in bacteria, alternative methods have emerged in recent years. In this regard, identification of lactic acid bacteria with good probiotic properties and determination of their probiotic properties are extremely important. In this study, 25 lactic acid bacteria were isolated from freshwater fish and identified at species level using phenotypic, biochemical and molecular tests. The pH tolerance, antagonistic activity and antibiotic sensitivity of these 25 strains were examined, and they were considered as bacteria displaying the best activity in the potential probiotic treatment of fish diseases. Lactococcus lactis species numbered F2, F4, F9 and F10 were determined to have a potential probiotic capacity.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":171084266,"openaccessinfo":{"externalids":{"MAG":"2948278365","ACL":null,"DOI":"10.22092\/IJFS.2018.118938","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The application of \u03c9-transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effective approach using low equivalents of the new diamine donor, cadaverine, which enables high conversions of challenging substrates to the corresponding chiral amines in excellent ee. This approach paves the way for the design of self-sufficient fermentation processes combining transaminase biotransformations with existing strategies for cadaverine production by decarboxylation of endogenous lysine.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263458897,"openaccessinfo":{"externalids":{"MAG":"2471047961","ACL":null,"DOI":"10.1002\/chem.201603188","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/nottingham-repository.worktribe.com\/file\/800997\/1\/EOR_Accepted%20Article.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"School bullying is a social phenomenon stemming from a complex interrelationship between the individuals and their environments. Underpinned by the social-ecological models, this study investigated the mediation of self-serving cognitive distortions (CDs) in the relationship between community violence exposure, as a victim and as a witness, and bullying perpetration. Bidirectional associations between violence exposure and bullying perpetration, and between CDs and bullying perpetration over time were also hypothesized. The study used a three-waves cross-lagged panel modeling in a sample of 829 Italian high school adolescents (46% males; Mage [Time 1; T1] = 12.71; Standard deviation [SD] = 1.68). The results showed that being exposed to community violence as a witness at T1 increased the development of CDs at Time 2 (T2), which in turn promoted the bullying perpetration at Time 3 (T3). Being exposed to community violence as a victim was not a significant predictor of CDs and bullying perpetration over time. Bidirectional associations were found between witnessing violence and bullying perpetration, and between CDs and bullying perpetration. The association between community violence exposure and individual moral cognitions over time plays a crucial role in predicting bullying perpetration. These findings highlight the need to consider both contextual and individual factors in understanding and preventing bullying perpetration.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209518456,"openaccessinfo":{"externalids":{"MAG":"2997605816","ACL":null,"DOI":"10.3390\/ijerph17010188","PubMedCentral":"6981769","ArXiv":null},"license":null,"url":"https:\/\/www.mdpi.com\/1660-4601\/17\/1\/188\/pdf?version=1578039435","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract Although the COVID-19 pandemic shows no signs of abating, public health strategies have transitioned from containment to harm reduction. In light of this paradigm shift, it is critical that individuals take steps to prevent the spread of SARS-CoV-2, the virus that causes COVID-19. In the United States, the CDC recommends that individuals wear face coverings in public places, such as grocery stores. As lockdowns are being phased out around the world, authorities are requiring the use of such masks in public places while maintaining social distance. Individuals (including healthcare professionals outside of their clinical settings) and manufacturers are following the CDC's recommendation. But, many currently available masks are not form-fitting, are not customizable, and are uncomfortable with even short-term use, thereby undercutting their effectiveness. Moreover, because cotton absorbs and retains the moisture found in an exhaled breath masks made of cotton have the potential to increase the wearer's risk of infection. Thus, as we shift to harm reduction and social distancing measures relax, it is imperative that these shortcomings in fabric masks are addressed and that is the motivation for this research. The overall objective of the research is to design, develop, and test a fabric mask that is effective while being comfortable during continuous use over long periods of time. As the first step in the design process, we reviewed the modes of transmission of SARS-CoV-2 virus. We analyzed a medical mask and a fabric mask in the market and identified their shortcomings. We carried out an in-depth analysis of user needs and developed the performance requirements of the proposed mask. We defined the architecture of the mask comprising the following principal components: Barrier, Form-Fitting, Positioning, and Fastening. We tested and evaluated candidate materials for the components and developed the design specifications and construction details for the mask. We produced the mask and carried out subjective testing on a user in a typical workplace setting; we demonstrated that the mask was form-fitting, customizable, washable, and could be worn continuously and routinely over extended periods of time by individuals and therefore could serve as an effective means to reduce the harm from SARS-CoV-2.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225399087,"openaccessinfo":{"externalids":{"MAG":"3048861169","ACL":null,"DOI":"10.1080\/00405000.2020.1805971","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"For transthoracic puncture of tuberculous caverns a trochar equipped with a photo-indicator is recommended. A relatively simple design of the instrument enables the surgeon to determine the instant of the trochar's tip penetrating the hollow of the cavern. The trochar-indicator may find wide application at the establishments of the antituberculous service in treating cavitary tuberculosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40564774,"openaccessinfo":{"externalids":{"MAG":"2398983028","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A106 Dietary vitamin E exists as either tocopherols or tocotrienols. Evidence indicates that vitamin Es other than \u03b1-tocopherol, may be potent cancer preventive agents. Growth arrest of the PC-3 prostate cancer cell lines was compared in the presence of dietary \u03b1-, \u03b3-, and \u03b4-vitamin E by the MTT assay. Physiological concentrations of \u03b3-tocotrienol were tested for apoptotic potential using fluorescent microscopy. QPCR, Western blot, PPAR \u03b3 dominant negative and scintillation proximity assays were used to determine the effects of vitamin E on PPAR \u03b3. The effect of vitamin E on 15-S-HETE was determined using ELISA. Tocotrienols induced more growth arrest than tocopherols. The gamma isoforms demonstrated selectivity for growth inhibition toward the cancer cells versus normal prostate epithelia. In PC-3 cells, cell death occurs with 1 \u00b5M at 24 hours and apoptosis occurs with 5 \u00b5M at 72 hours. PPAR \u03b3 was up regulated by dietary \u03b3-vitamin Es. Dietary \u03b3-vitamin E mediated growth arrest was demonstrated to be PPAR \u03b3-dependent using a PPAR \u03b3 dominant negative vector. Neither \u03b3-vitamin Es are direct PPAR \u03b3 ligands. Concentrations of 15-S-HETE in PC-3 cells were found to be up regulated by treatment with R-\u03b3 tocotrienol. These data support that tocotrienols could be more effective as prostate chemopreventive agents than tocopherols. As the \u03b3-vitamin Es are not direct PPAR \u03b3 ligands, and 15-S-HETE is up regulated, our data suggest that R-\u03b3-tocotrienol modulates arachidonic acid metabolism by up regulation of 15-S-HETE which induces the PPAR \u03b3 pathway, potentiating apoptosis.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":99278127,"openaccessinfo":{"externalids":{"MAG":"2571190214","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have studied the locally released early-season melon varieties (cv. Anush), cucumber (cv. Maneh), and marrow squash (cv. Anna) under the conditions of Ararat valley to assess the influence of meteorological conditions on the development rates and productivity of the summer and spring-planted vegetable plants. Research has been conducted on the experimental field of the Scientific Center of Vegetable, Melon and Industrial Crops (2011-2013). Depending on the seeding time (spring or summer), the tested varieties varied in the durations of germination, blooming and fruit formation periods as well as in\u00a0 the plant resistance to low and high temperatures in spring and summer, respectively. It was found that, the summer-planted cucurbits crops have significantly shorter plant development phenological phases and prolonged fruit-bearing periods as compared to the spring-planted plants. It was proved for cucumber and marrow squash crops. The yields of the spring-planted melon, cucumber and marrow squash crops were 30,5; 24,8 and 42,5 t\/ha, respectively, while the yields of the summer-planted crops were lower (39,9; 7,8 and 8,6%).","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":130783259,"openaccessinfo":{"externalids":{"MAG":"2245647797","ACL":null,"DOI":"10.18619\/2072-9146-2015-1-57-59","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.vegetables.su\/jour\/article\/download\/70\/73","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Osteogenesis imperfecta type V (OI-V) has a wide clinical variability, with distinct clinical\/radiological features, such as calcification of the interosseous membrane (CIM) between the radius-ulna and\/or tibia-fibula, hyperplastic callus (HPC) formation, dislocation of the radial head (DRH), and absence of dentinogenesis imperfecta (DI). Recently, a single heterozygous mutation (c.-14C>T) in the 5\u2032UTR of the IFITM5 gene was identified to be causative for OI-V. Here, we describe 7 individuals from 5 unrelated families that carry the c.-14C>T IFITM5 mutation. The clinical findings in these cases are: absence of DI in all patients, presence of blue sclera in 2 cases, and 4 patients with DRH. Radiographic findings revealed HPC in 3 cases. All patients presented CIM between the radius and ulna, while 4 patients presented additional CIM between the tibia and fibula. Spinal fractures by vertebral compression were observed in all individuals. The proportion of cases identified with this mutation represents 4% of OI cases at our institution. The clinical identification of OI-V is crucial, as this mutation has an autosomal dominant inheritance with variable expressivity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5503311,"openaccessinfo":{"externalids":{"MAG":"2246434993","ACL":null,"DOI":"10.1159\/000439506","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.karger.com\/Article\/Pdf\/439506","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The objective of this study was to determine the effects of an Aspergillus oryzae fermentation extract (Amaferm) as well as other factors on lactate utilization by the ruminal bacterium Megasphaera elsdenii B159. Addition of Amaferm or a filter-sterilized Amaferm filtrate stimulated L-lactate uptake by both M. elsdenii and the ruminal selenomonad strain H18. Growth of M. elsdenii in medium that contained DL-lactate (2 g\/L), Trypticase, and yeast extract was only slightly stimulated by the addition of 5% (vol\/vol) Amaferm filtrate after 24 h. However, growth of M. elsdenii in a similar medium lacking Trypticase and yeast extract was increased over twofold by the addition of either 2 or 5% (vol\/vol) Amaferm filtrate. These results suggest that Amaferm provides growth factors (i.e., amino acids, B vitamins) to support growth of M. elsdenii on lactate. There was no inhibition of L-lactate uptake when lactate-grown cells of M. elsdenii were incubated with excess (10 mM) glucose, sucrose, or maltose. In addition, when cells were grown on glucose, sucrose, or maltose rather than lactate there was little difference in L-lactate uptake, suggesting that L-lactate transport in M. elsdenii is not subject to catabolite repression by these soluble sugars. Both K+ and Na+ had little effect on L-lactate uptake. Uptake was unaffected at extracellular pH values between 6.0 and 8.0, whereas pH values of 5.0 and 4.0 increased uptake. In addition, L-lactate uptake was inhibited between 34 and 61% by protonophores. These results suggest that protons may be involved in the uptake of L-lactate by M. elsdenii B159.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7586987,"openaccessinfo":{"externalids":{"MAG":"2413313630","ACL":null,"DOI":"10.2527\/1993.71102770X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the context of online role-playing games, we evaluate offloading AI computation from game servers to game clients. In this way, the aggregate resources of thousands of participating client machines can enhance game realism in a way that would be prohibitively expensive on a central server. Because offloading can add significant latency to a computation normally executing within a game server's main loop, we introduce the mechanism of AI partitioning: splitting an AI into a high-frequency but computationally simple component on the server, and a lowfrequency but computationally intensive component offloaded to a client. By designing the client-side component to be stateless and deterministic, this approach also facilitates rapid handoff, preemptive migration, and replication, which can address the problems of client failure and exploitation. To explore this approach, we develop an improved AI for tactical navigation, a challenging task to offload because it is highly sensitive to latency. Our improvement is based on calculating influence fields, partitioned into server-side and client-side components by means of a Taylor series approximation. Experiments on a Quake-based prototype demonstrate that this approach can substantially improve the AI's abilities, even with server-clientserver latencies up to one second.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":18036082,"openaccessinfo":{"externalids":{"MAG":"2097639567","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study evaluated space- time variation of water quality data sets for the Wadi Andlou Kasserine, Tunisia, using multivariate analytical techniques including cluster analysis, principal component analysis (PCA) and correlation analysis (CA). The present study showed that values of temperature (T), electrical conductivity (EC), biochemical oxygen demand (BOD), chemical oxygen demand (COD), chloride, phosphate, sulfate, fecal coliform, Streptococcus, Salmonella spp., and Enterococci were significantly higher in the dry season compared to samples taken in the wet season. Concurrently, pH, dissolved oxygen (DO), turbidity, suspended matter (SM), NH4+ presented values significantly lower in dry season than surveys in rainy season. The following parameters BOD5, COD, SO42\u2013, Cl\u2013, SM, Salmonella spp. did not meet the Tunisian standard NT 106 for surface water quality. Analysis of pollutant concentrations via PCA showed that the two first components accounted for 87.34 and 93.17% of the total variance for dry and rainy season sampling, respectively. The first component included T, pH, EC, SM, SO42\u2013, Cl\u2013, NH4+, turbidity, COD, BOD, PO43\u2013, Enterococci, fecal coliform and streptococcus, Salmonella spp. and total bacteria. The second included DO and NO3\u2013. Cluster analysis identified the five sampling sites into three groups in the rainy and dry season based on seasonal differences and various pollution levels caused by physicochemical and bacteriological properties. The results suggest that future monitoring can include fewer sampling sites, and stratified random sampling plans can save time and resources.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":104104390,"openaccessinfo":{"externalids":{"MAG":"2739927830","ACL":null,"DOI":"10.1002\/CLEN.201500471","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents two bus coding schemes for power optimization of application-specific systems: partial pus-invert coding and its extension to multiway partial bus-invert coding. In the first scheme, only a selected subgroup of bus lines is encoded to avoid unnecessary inversion of relatively inactive and\/or uncorrelated bus lines which are not included in the subgroup. In the extended scheme, we partition a bus into multiple subbuses by clustering highly correlated bus lines and then encode each subbus independently. We describe a heuristic algorithm of partitioning a bus into subbuses for each encoding scheme. Experimental results for various examples indicate that both encoding schemes are highly efficient for application-specific systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":10849285,"openaccessinfo":{"externalids":{"MAG":"2163949832","ACL":null,"DOI":"10.1109\/92.924059","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Declining episodic memory is common among otherwise healthy older adults, in part due to negative effects of aging on hippocampal circuits. However, there is significant variability between individuals in severity of aging effects on the hippocampus and subsequent memory decline. Importantly, variability may be influenced by modifiable protective physiological factors such as cardiorespiratory fitness (CRF). More research is needed to better understand which aspects of cognition that decline with aging benefit most from CRF. The current study evaluated the relation of CRF with learning rate on the episodic associative learning (EAL) task, a task designed specifically to target hippocampal\u2010dependent relational binding and to evaluate learning with repeated occurrences. Results show higher CRF was associated with faster learning rate. Larger hippocampal volume was also associated with faster learning rate, though hippocampal volume did not mediate the relationship between CRF and learning rate. Furthermore, to support the distinction between learning item relations and learning higher\u2010order sequences, which declines with aging but is largely reliant on extra\u2010hippocampal learning systems, we found learning rate on the EAL task was not related to motor sequence learning on the alternating serial reaction time task. Motor sequence learning was also not correlated with hippocampal volume. Thus, for the first time, we show that both higher CRF and larger hippocampal volume in healthy older adults are related to enhanced rate of relational memory acquisition.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":201658260,"openaccessinfo":{"externalids":{"MAG":"2971200557","ACL":null,"DOI":"10.1002\/hipo.23151","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7850579","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Insulin signaling is a conserved pathway in all metazoans. This pathway contributed toward primordial metazoans responding to a greater diversity of environmental signals by modulating nutritional storage, reproduction, and longevity. Most of our knowledge of insulin signaling in insects comes from the vinegar fly, Drosophila melanogaster, where it has been extensively studied and shown to control several physiological processes. Mosquitoes are the most important vectors of human disease in the world and their control constitutes a significant area of research. Recent studies have shown the importance of insulin signaling in multiple physiological processes such as reproduction, innate immunity, lifespan, and vectorial capacity in mosquitoes. Although insulin-like peptides have been identified and functionally characterized from many mosquito species, a comprehensive review of this pathway in mosquitoes is needed. To fill this gap, our review provides up-to-date knowledge of this subfield.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":84846526,"openaccessinfo":{"externalids":{"MAG":"2923214423","ACL":null,"DOI":"10.3389\/fendo.2019.00166","PubMedCentral":"6448002","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2019.00166\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We explore the determinants of debt and financial asset accumulation at the household level using survey data for Great Britain, Germany and the United States (US). Given that debt and assets are both components of a household's financial portfolio, we explore the degree of inter-dependence between households' assets and liabilities by jointly modelling these two aspects of the portfolio. Indeed, our empirical findings for both countries support a high degree of inter-dependence between debt and asset holding. Furthermore, the nature of this inter-dependence varies across income ranges and age groups with the weakest correlation between financial assets and debt being found for the lowest income groups in Great Britain, suggesting that such groups may be particularly vulnerable to adverse financial shocks. Evidence supporting inter-dependence between assets and debt no longer remains, however, once we focus on debtors which suggests that households in debt may potentially face difficulties following adverse changes in their financial situation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":166826575,"openaccessinfo":{"externalids":{"MAG":"1502299786","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to analyze the similarities, differences, and transferability of students' writing strategies in L1 (Indonesian) and L2 (English). Data were obtained from four participants majoring in English Education, two males and two females, which were categorized into skilled and less-skilled writers. The data were collected for four months using various methods, namely think-aloud protocols (TAPs), retrospective and semi-structured interviews, observations, and written drafts. The result showed that students employed similar personal strategies while writing in Indonesian (L1) and English (L2). This means that they transferred L1 strategies to L2 with some variances and similarities. The skilled writers viewed writing as a cyclical process of planning, writing, reading\/rereading, rehearsing, and revising their texts. Meanwhile, less-skilled writers tended to employ linear and less recursive strategies. Furthermore, subsequent studies need to be conducted using these research findings and suggestions.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":229368490,"openaccessinfo":{"externalids":{"MAG":"3109929025","ACL":null,"DOI":"10.23887\/jpi-undiksha.v9i3.28496","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.23887\/jpi-undiksha.v9i3.28496","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Expansion of urbanized areas heavily changed cultural landscapes' features in many European countries. Mountain territories have been hit by such processes too; due to their peculiar social and topographical characteristics these effects have been greater than in other territories. Moreover, urbanization expansion process in the Alps is strongly related with temporary dynamics depending from touristic fluxes, implementation of new spaces of mobility, economic development and living. In a context of extreme land scarcity like in the Alps, urban sprawl and dwellers' search for nature proximity to homes and residential areas put territorial governance instruments under pressure and opens up complex questions. Beside other experiences between urban and peripheral spaces, the essay aims at speculating that typical rural communitarian governance models are able to strengthen collective interests over individual ones and can be translated into urban governance models by public authorities. Direct observations in the city of Trento demonstrated how citizens even where specific collective governance models are not commonly applied \u2013 involved in specific projects are able to generate systemic solution and self-develop associative and cooperative models to regenerate open spaces around the city. Such examples can be considered as pilots to be extended to other (alpine) urban territories following an approach that the city of Trento is implementing through different participatory policy instruments or through European projects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":211114543,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose \n \n \n \n \nThe purpose of this paper is to examine the barriers preventing women in prostitution from accessing co-ordinated health services in the Republic of Ireland. By examining the experiences of migrant women engaged in prostitution, the research contributes to knowledge pertaining to the psychosocial experiences of female sex workers' access to healthcare. \n \n \n \n \nDesign\/methodology\/approach \n \n \n \n \nThe study interviewed migrant women across Ireland, using a biographical narrative approach and an adapted voice-centred relational model of analysis to determine the necessity for a health promotion strategy for this demographic. \n \n \n \n \nFindings \n \n \n \n \nThe findings indicate migrant women work primarily indoors, hold precarious legal status and are in Ireland due to processes of globalisation, migration and economic necessity. The women discussed their entry into prostitution and their experiences within prostitution in the context of their psychosocial experiences. \n \n \n \n \nResearch limitations\/implications \n \n \n \n \nWhile the findings are from a small qualitative sample confined to the Republic of Ireland, it is the first study to prioritise migrant sex workers' psychosocial experiences in Ireland. \n \n \n \n \nPractical implications \n \n \n \n \nThe research concludes education and service development that respects the various social determinants impacting women in prostitution is missing but remains necessary in Ireland. It finds a gendered reform of policies using an ecological framework for health that can address issues of poverty, migration and the global trends of the sex industry. \n \n \n \n \nSocial implications \n \n \n \n \nThis means a national review of current services in health, social work and community development fields is timely. \n \n \n \n \nOriginality\/value \n \n \n \n \nThis paper gives insight into the lives of migrant women involved in the sex industry and can make an important contribution to future research directions and practice in Irish and European prostitution contexts.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":80559839,"openaccessinfo":{"externalids":{"MAG":"2766007669","ACL":null,"DOI":"10.1108\/IJMHSC-04-2016-0017","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Studies on training\/expertise\u2010related effects on human brain in context of neuroplasticity have revealed that plastic changes modulate not only task activations but also patterns and strength of internetworks and intranetworks functional connectivity in the resting state. Much has known about plastic changes in resting state on global level; however, how training\/expertise\u2010related effect affects patterns of local spontaneous activity in resting brain remains elusive. We investigated the homogeneity of local blood oxygen level\u2010dependent fluctuations in the resting state using a regional homogeneity (ReHo) analysis among 16 acupuncturists and 16 matched nonacupuncturists (NA). To prove acupuncturists' expertise, we used a series of psychophysical tests. Our results demonstrated that, acupuncturists significantly outperformed NA in tactile\u2010motor and emotional regulation domain and the acupuncturist group showed increased coherence in local BOLD signal fluctuations in the left primary motor cortex (MI), the left primary somatosensory cortex (SI) and the left ventral medial prefrontal cortex\/orbitofrontal cortex (VMPFC\/OFC). Regression analysis displayed that, in the acupuncturists group, ReHo of VMPFC\/OFC could predict behavioral outcomes, evidenced by negative correlation between unpleasantness ratings and ReHo of VMPFC\/OFC and ReHo of SI and MI positively correlated with the duration of acupuncture practice. We suggest that expertise could modulate patterns of local resting state activity by increasing regional clustering strength, which is likely to contribute to advanced local information processing efficiency. Our study completes the understanding of neuroplasticity changes by adding the evidence of local resting state activity alterations, which is helpful for elucidating in what manner training effect extends beyond resting state. Hum Brain Mapp 35:1074\u20131084, 2014. \u00a9 2013 Wiley Periodicals, Inc.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":31115493,"openaccessinfo":{"externalids":{"MAG":"1557994799","ACL":null,"DOI":"10.1002\/hbm.22235","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc6869809?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0Total Electron Content (TEC) constitutes one of the key elements for observing the variable structure of the ionosphere. GPS provides a cost-effective alternative in TEC estimation through earth-based receivers. In this paper, one of the TEC estimation methods, namely Reg-Est, is investigated in detail in terms of its parameters and developed further to include improvements. Reg-Est estimates robust TEC using GPS measurements of 30 s time resolution. The method combines the vertical TEC computed from all the satellites in view over 10\u00b0 horizon limit in the least squares sense through the minimization of a cost function which also includes a high pass penalty filter. Optional weighting functions and sliding window median filters are added to enrich the processing and smoothing of the data. In this study, the input to the Reg-Est is enlarged to include phase-corrected TEC. The best way of including the instrumental biases is investigated and the algorithm is updated to include the biases in the slant TEC computation. The effect of the thin shell height of the ionosphere in Reg-Est estimates is studied. It is concluded that the Reg-Est algorithm is very robust to the choice of thin shell height. The best weighting function to reduce the multipath effects and to minimize the non-ionospheric noise is selected. The improved Reg-Est algorithm can be used for all latitudes and for both quite and disturbed days of the ionosphere. The Reg-Est TEC are in excellent accordance with the estimates from IGS analysis centers.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":129764864,"openaccessinfo":{"externalids":{"MAG":"2020645823","ACL":null,"DOI":"10.1029\/2007JA012459","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary. \n Generic limits and relationships in tribe Cereeae are reviewed and reassessed using cladistic methodology. Based on field and herbarium studies, and on reliable published observations, 20 characters are discussed in detail, polarized into plesiomorphic (primitive) and apomorphic (derived) states and then employed in the generation of a series of phylogenetic hypotheses using the PAUP computer program. Melocactus, Coleocephalocereus (incl. subg. Buiningia but excl. subg. Lagenopsis), Micranthocereus and Austrocephalocereus (excl. Espostoopsis dybowskii) represent a monophyletic group, here provisionally designated subtribe Melocactinae F. Buxbaum, and defined by the following synapomorphies: (1) loss of well-developed stem wood, (2) sunken-lateral or terminal cephalium, (3) nonblackening floral remains, and (4) derived fruit apex morphology (superficial floral remains). Uebelmannia, whose placement in tribe Cereeae is at best provisional, may also belong to this group, unless its similarities are due to convergence. Coleocephalocereus and Austrocephalocereus lack obvious autapomorphies distinguishing them from Melocactus and Micranthocereus, respectively. The superficial pseudocephalium present in most species of Micranthocereus may have been derived from the sunken-lateral type characteristic of this group. The remaining genera of the tribe, i.e. the Cereinae Britton & Rose, are more loosely related with relatively few synapomorphies. Pilosocereus sens. str. (incl. Pseudopilocereus) is clearly defined by the apomorphies of loss of well-developed stem wood (in parallel with the Melocactinae) and more or less depressed, dehiscent fruits (fruit dehiscence evolved in parallel in Cereus sens. lat.). 'Lagenopsis' (Cereus luetzelburgii) may have common ancestry with Stephanocereus, which is allied to Arrojadoa by the synapomorphic ring cephalium. Assessment of the precise relationship and appropriate classification (rank) of these three taxa, and a potentially related but inadequately known undescribed species, must await more comprehensive data, since at present it is not possible to be certain whether they have had a close common ancestry or are in part the product of convergence. Espostoopsis dybowskii is inadequately known, but does not appear to belong in Austrocephalocereus or Melocactinae; it may even be out of place in Cereeae (cf. Trichocereeae, especially Espostoa). Brasilicereus has no synapomorphies with, and various autapomorphies distinguishing it from, Cereus, and should be recognized as a genus. Cipocereus is defined by indehiscent fruits with colourless, watery pulp and should not be sunk into Pilosocereus. It is amplified to include Floribunda pusilliflora, Cereus crassisepalus and Pilosocereus bradei, besides C. minensis (C. pleurocarpus) and an undescribed species. Cereus sens. lat. (incl. subg. Ebneria, Mirabella minensis, Praecereus and Subpilocereus) is a primitive complex that cannot be resolved in terms of synapomorphies at present. Either of Cereus, Cipocereus or Brasilicereus\u2014the genera with fewest synapomorphies\u2014may be closest to the ancestor of the tribe. A key to the principal taxa of tribe Cereeae is provided.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90972560,"openaccessinfo":{"externalids":{"MAG":"2781834728","ACL":null,"DOI":"10.25223\/brad.n7.1989.a2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Three strains of Fusobacterium necrophorum biovar C were injected into mice intraperitoneally and intraportally. All the mice survived. In one mouse out of 15 mice injected intraperitoneally, a few focal abscesses were formed in the liver. The microorganisms were recovered from the liver abscess and the tissue of liver with abscess. No changes were observed in the organs of other 14 mice and no bacteria were recovered from them. In the 15 mice injected intraportally, no liver abscesses and no macroscopic changes in the organs were formed. However, the inoculated bacteria were recovered from the liver of four mice. The pathogenicity of F. necrophorum biovar C was weaker than that of other two biovars.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26303217,"openaccessinfo":{"externalids":{"MAG":"2043517555","ACL":null,"DOI":"10.1292\/JVMS1939.51.1111","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The schlieren interferometry is a powerful tool when used in materials laser radiation processing, allowing a better understanding of related thermal phenomena on the sample. However, it is observed that, when refractive index gradients became too high, the method reaches to its applicability limit, no longer behaving as a schlieren interferometer. It is expected that the use of deflection diagnostic techniques and Mie scattering visualization can complement this method, overcoming their limitations.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2014-10":1,"2015-11":1,"unknown":2}},"corpusid":120870523,"openaccessinfo":{"externalids":{"MAG":"1679334433","ACL":null,"DOI":"10.1109\/CLEOE.2003.1313556","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An increasing organ demand is facing a constant number of donors. Nevertheless, not all organs are utilized due to a limited time window for heart transplantation (HTX). Therefore, we aimed to evaluate, if iron chelator supplemented Bretschneider solution can protect the graft in a clinically relevant canine model of HTX with prolonged ischemic storage.HTX was performed in foxhounds. The ischemic time was standardized to 4h, 8h, 12h or 16h depending on the experimental group. Left ventricular (LV) and vascular function were measured. Additionally, myocardial high energy phosphate and iron content and in-vitro myocyte force were evaluated.Iron chelator supplementation proved superior at a routine preservation time of 4h as well as for prolonged times of 8h and longer. The supplementation groups recovered quickly compared to their controls. The LV function was preserved and coronary blood flow increased. This was also confirmed by in vitro myocyte force and vasorelaxation experiments. Additionally, the biochemical results showed significantly higher adenosine-triphosphate content in supplementation groups. The iron chelator LK614 played an important role in this mechanism by reducing the chelatable iron content.This study shows that iron chelator supplemented Bretschneider solution effectively prevents myocardial\/endothelial damage during short as well as long term conservation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238711901,"openaccessinfo":{"externalids":{"MAG":"3193679351","ACL":null,"DOI":"10.21203\/rs.3.rs-677187\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-677187\/latest.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The fabrication and characterization of tungsten nanoelectrodes insulated with cathodic electrophoretic paint is described together with their application within the field of neurophysiology. The tip of a 127 \u00b5m diameter tungsten wire was etched down to less than 100 nm and then insulated with cathodic electrophoretic paint. Focused ion beam (FIB) polishing was employed to remove the insulation at the electrode's apex, leaving a nanoscale sized conductive tip of 100\u20131000 nm. The nanoelectrodes were examined by scanning electron microscopy (SEM) and their electrochemical properties characterized by steady state linear sweep voltammetry. Electrode impedance at 1 kHz was measured too. The ability of a 700 nm tipped electrode to record well-isolated action potentials extracellularly from single visual neurons in vivo was demonstrated. Such electrodes have the potential to open new populations of neurons to study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10993238,"openaccessinfo":{"externalids":{"MAG":"2089247365","ACL":null,"DOI":"10.1088\/0957-4484\/16\/9\/032","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1356817?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to cross-culturally investigate the instructional efficacy of the Common Knowledge Construction Model (CKCM) with college students learning about 'factors affecting solubility' focusing on students' conceptual understanding, attitudes and scientific habits of mind. Even though the CKCM is a decade old, there has been little study of its effectiveness in different cultural contexts, which is unfortunate because having effective studies from different cultural contexts can increase the strength of generalization. In order to add to the cultural context variation in which the CKCM has been studied, the study reported in this paper investigated the effectiveness of a CKCM undergraduate chemistry unit taught in Turkey and the USA for pre-service teachers. The study was quasi-experimental with the CKCM and country as the independent variables; and conceptual understanding, scientific habits of mind and attitudes towards chemistry as the dependent variables. Data were collected using a pre\/post-test administration of the Factors Affecting Solubility Test (FAST), the Scientific Habits of Mind (SHOM) survey, and the Chemistry Attitudes and Experiences Scale (CAES). The data were analyzed using an independent samples t-test, paired samples t-test, and ANCOVA. Statistically significant differences were found between contexts, generally favoring the Turkish pre-service teachers. This is an interesting result in that the findings of the study suggest that the CKCM may be more effective in its adapted setting than in its original (American) setting.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":148810162,"openaccessinfo":{"externalids":{"MAG":"2622615468","ACL":null,"DOI":"10.1039\/C7RP00016B","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary Kerogen typing and maturation studies have been conducted in order to rationalise the variations in hydrocarbon types observed in the Moray Firth and South Viking Graben in the U.K. North Sea. The distribution of terrestrially-derived kerogen follows accepted models for water-borne transport. The occurrence of amorphous debris of algal origin in significant amounts is related to variations in the environment of deposition. Although the relationship between the major kerogen groups and their range of hydrocarbon product is established, the type and quantity of generated hydrocarbons could only be predicted from organic facies if the maturity of the source rocks were known. Maturity maps were therefore constructed from thermal gradients, burial histories and measured maturity (spore colour). The resulting predictive model of the distribution of oils, condensate and gas correlates favourably with observed hydrocarbon occurrences and is now an integral part of Britoil's ongoing exploration programme.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":131065241,"openaccessinfo":{"externalids":{"MAG":"2172080764","ACL":null,"DOI":"10.1144\/GSL.SP.1983.012.01.17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The connections between vicarious trauma and the viewing of violent User-Generated Content are becoming an increasingly important topic in journalism. As more journalist work begins to rely, or at least incorporate UGC, the risks to journalists have been shown to increase. This can lead to short, unpleasant careers, and in some cases, serious, long lasting mental health risks. Yet while this discussion is beginning to unfold in the newsroom, universities are lagging behind in their understanding of the topic. This paper, through content analysis of undergraduate course materials, and through interviews with lecturers and journalists, found that almost no course in the UK is teaching the risks of vicarious trauma or UGC. It was found that while some educators wish to make more of the topic, a number of institutional factors, such as lack of training and time, worries over duty of care, and available resources make this a difficult, if not impossible task. The paper recommends a new emphasis is placed on vicarious trauma, coupled with training and interdepartmental support.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":149058721,"openaccessinfo":{"externalids":{"MAG":"2756820333","ACL":null,"DOI":"10.1386\/AJMS.7.2.407_1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traffic data fusion has much to do with combining available or considered data sources in the best possible way. In this, it is very similar to optimizing a portfolio of financial assets in regard of return and risk. This article draws the analogy between these two mostly different scientific worlds, i.e. finance and engineering. Similarities and differences in context of weighted-mean data fusion based on numerical traffic flow measurements such as travel times or speeds are discussed. This, in particular, includes guessing the potential benefit of negative weights. Optimal weights are derived following a strict mathematical theory based on assumptions (parameters) about systematic bias and correlations of the considered data sources. Moreover, a specific way of reducing the systematic bias of the fusion results is proposed and compared to common methods. The whole approach is demonstrated based on position data from two independent vehicle fleets in Athens, Greece. In this context, the problem of parameter calibration is solved by applying an advanced tool for such floating car data systems, called \"self-evaluation\". The experiments show that the proposed methods reliably reduce the systematic bias and variance of the fusion results with regard to the original data as well as in comparison to the naive fusion approach that uses equal weights for all data sources.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122865977,"openaccessinfo":{"externalids":{"MAG":"2132566908","ACL":null,"DOI":"10.1002\/ATR.1351","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper focuses on Koos Prinsloo's Weifeling , the last collection of fiction to appear in the writer's brief career In this article it is argued that Prinsloo's work is characterized in the first instance by an oppositional practice driven by a will to reveal which involves, inter alia , a collapse of the distinction between the private and the public. This revelatory urge is, however, compromised by residual attachment and a self-reflective practice which deconstructs the identity of the self even as it is revealed Linda Hutcheon's description of postmodernism's ethical stance as one of \"complicitous critique\" and a strategically modified version of her description of postmodernist fiction as \"historiographic metafiction\" are used to theorize this aspect of Prinsloo's writing, although the texts under discussion remain undeniably more critical than complicit in their practice. Finally, the confrontations with death in the closing texts of Weifeling are linked to Brian McHale's arguments about postmodernism's characteristic foregrounding of ontological differences.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144317694,"openaccessinfo":{"externalids":{"MAG":"2053372519","ACL":null,"DOI":"10.4102\/LIT.V16I1.577","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Earthquake early warning system (EEWS) plays an important role in detecting ground shaking during an earthquake and alerting the public and authorities to take appropriate safety measures, reducing possible damages to lives and property. However, the cost of high-end ground motion sensors makes most earthquake-prone countries unable to afford an EEWS. Low-cost Microelectromechanical systems (MEMS)-based ground motion sensors are becoming a promising solution for constructing an affordable yet reliable and robust EEWS. This paper contributes to advancing Earthquake early warning (EEW) research by conducting a literature review investigating different methods and approaches to building a low-cost EEWS using MEMS-based sensors in different territories. The review of 59 articles found that low-cost MEMS-based EEWSs can become a feasible solution for generating reliable and accurate EEW, especially for developing countries and can serve as a support system for high-end EEWS in terms of increasing the density of the sensors. Also, this paper proposes a classification for EEWSs based on the warning type and the EEW algorithm adopted. Further, with the support of the proposed EEWS classification, it summarises the different approaches researchers attempted in developing an EEWS. Following that, this paper discusses the challenges and complexities in implementing and maintaining a low-cost MEMS-based EEWS and proposes future research areas to improve the performance of EEWSs mainly in 1) exploring node-level processing, 2) introducing multi-sensor support capability, and 3) adopting ground motion-based EEW algorithms for generating EEW.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":253260685,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fsens.2022.1020202","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsens.2022.1020202\/pdf?isPublishedV2=False","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The MODIS Protoflight Model, launched on-board the NASA EOS Terra spacecraft on 18 December 1999, has been in operation for more than two years, providing the science community with calibrated data sets for global studies of the Earth's land, oceans and atmosphere. MODIS has 36 spectral bands, covering the spectral range from 412 nm to 14 200 nm, and provides spatial resolutions of 0.25 km (two bands), 0.5 km (five bands) and 1 km (29 bands) at nadir. The key on-board calibrators (OBCs) include a solar diffuser (SD) and a solar diffuser stability monitor (SDSM) system for calibration of the reflective solar bands, and a V-grooved flat-panel blackbody (BB) for calibration of the thermal emissive bands. In this paper, we describe the use of OBCs for the sensor's radiometric calibration and characterization and discuss on-orbit performance. In addition, we provide an assessment of the on-orbit degradation of the SD and MODIS optics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250742535,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0026-1394\/40\/1\/320","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effect of pentobarbital anesthesia on plasma renin activity (PRA) and mean arterial pressure (MAP) was studied in chronically catheterized dogs maintained on normal or low-sodium intake. Within 1 min of administration, pentobarbital caused a rapid fall in MAP which was followed by a restoration of MAP toward control within 5 min. Thirty minutes after induction of anesthesia, PRA was unchanged in sodium-replete dogs and elevated two-fold in sodium-depleted dogs. MAP was significantly lowered (20 mmHg) in normal salt dogs and only slightly decreased in low-salt dogs 30 min after pentobarbital. MAP returned to preanesthetic control value in dogs given converting enzyme inhibitor before anesthesia. Surgical stress or cutaneous electrical stimulation causey hexamethonium. These results indicate that change in PRA and MAP of pentobarbital-anesthetized dogs is significantly influenced by the sodium intake of the animal and by the degree of surgical stress.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":43250223,"openaccessinfo":{"externalids":{"MAG":"2404124921","ACL":null,"DOI":"10.1152\/AJPLEGACY.1976.231.4.1185","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Most upper Homerian and Ludfordian retiolitines have a tubarium with hexagonal meshes and a\u00a0zigzag pattern in the middle part of their lateral walls, a shallow ancora umbrella, and a free nema. Hoffmanigraptus varsoviensis n. gen., n. sp. is described from isolated, three-dimensional material, from the upper part of the Colonograptus praedeubeli Biozone (upper Homerian, Silurian) of Poland, Baltica, and represents one of the earliest forms with this construction. This type of tubarium is represented by the upper Homerian Doliograptus Lenz\u00a0& Koz\u0142owska-Dawidziuk, 2002 and Spinograptus Bou\u010dek\u00a0& M\u00fcnch, 1952, differing from Hoffmanigraptus n. gen. mainly in larger proximal lateral orifices, pattern of clathrial lists on lateral walls, as well as size and shape of tubaria. Hoffmanigraptus n. gen. has a tubarium widening medially, tapering towards the distal end and forming a finite tubarium, with a possible three-vaned nematularium. Flattened specimens Plectograptus? ovatus Koz\u0142owska, Lenz & \u0160torch, 2001 and Plectograptus? karlsteinensis Koz\u0142owska, Lenz & \u0160torch, 2001, preserved on a rock surface from the Barrandian area are assigned to the new genus. They are of the same upper Homerian age, and show the main features of the new form. Hoffmanigraptus n. gen. is regarded as an early member of the Plectograptus clade.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":245199343,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5852\/cr-palevol2021v20a45","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/sciencepress.mnhn.fr\/sites\/default\/files\/articles\/pdf\/comptes-rendus-palevol2021v20a45.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Quality of healthcare services, patient safety and staff satisfaction the essence of accreditation,are indispensable to favourable patient outcomes. This study aimed at identifying opportunities forimprovement based on extent of conformance to existing applicable accreditation standards.Method: A cross-sectional observational study was conducted in an apex public sector ophthalmichospital in India during March and April 2016. Opportunities for improvement identified based on extentof compliance to accreditation standards as per criteria laid in NABH self-assessment toolkit. Reviewsof hospital departments, services and functions were done through document review; visit to differentpatient care areas; staff and patient interviews were conducted. A sample of ten observations was takenfor each objective element from same or different areas based on applicability and scored as full, partial ornon-compliant (0, 5, 10 respectively).Gaps were identified based on score less than 50% of aggregate orindividual standard with more than two zeros.Results: Hospital was compliant to accreditation standards of NABH with an overall score of 74%. Allregulatory requirements met. Opportunities for improvement identified were related to quality assuranceof labs, cardio-pulmonary resuscitation, pain assessment, awareness and reporting of medication errors,redressal mechanism, effective implementation of patient safety and quality improvement programmes.Continuous quality improvement chapter had lowest compliance (39%).Conclusion: The hospital met accreditation requirements except those related to documentation andcontinuous quality improvement (an advanced stage of accreditation) amongst few others which arepredominantly specifically oriented to accreditation related activities. The study delineates how the identifiedopportunities can be met based on interpretation of the standards. The study is limited by the fact thatdocumentation in the form of circulars and a Residents' Manual which are not as per the requirements ofNABH have been considered.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225877810,"openaccessinfo":{"externalids":{"MAG":"3033205486","ACL":null,"DOI":"10.37506\/MLU.V20I2.1136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Foreword: Human Health and Global Crisis by Tim Lobstein Preface: Tragic Blindness 1. Wave of Panic Across the Planet 2. Badnosh and Other Paradoxes of the Abundant Society 3. Revolution on our plates 4. Agriculture in the Age of More is More 5. Welcome to Wal-Mart 6. Culprits or Scapegoats? 7. Go Active! 8. Slimming with Pills 9. Prevention is Better than Cure 10. Some Leads and their Limits 11. Obesity and Climate Change: An Odd Couple Epilogue: At the Crossroads Bibliography Index","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128300575,"openaccessinfo":{"externalids":{"MAG":"656703445","ACL":null,"DOI":"10.5860\/choice.47-1455","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Temephos and spinosad are pesticides used for control of vector-borne diseases such as dengue, chikungunya and zika. However, the inadequate use of these substances has affected the health of non-target organisms. The aim of this study was to evaluate and compare, the effects of temephos and spinosad on leukocyte viability and death, using guppy fish (Poecilia reticulate) as a model organism. Guppies were exposed to temephos (10 mg\/L) and spinosad (0.5 mg\/L) for 7, 14, and 21 days. Afterwards, they were placed in pesticide-free fish tanks (7, 35, and 70 days) for recovery. The results showed that exposure to temephos caused leukocyte death, even at 35 days of recovery. Contrarily, the exposure to spinosad did not cause leukocyte death. This research show, for the first time, that a single dose of temephos causes apoptosis up to 56 days post-exposition, indicating that this pesticide induces chronic effects on immune response cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220518189,"openaccessinfo":{"externalids":{"MAG":"3043192792","ACL":null,"DOI":"10.1080\/09603123.2020.1791803","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Small and medium-sized enterprises (SMEs) play an important and crucial role in both developed and developing countries. They contribute significantly to economic growth through employment opportunities, productivity, entrepreneurial improvements, and innovative solutions. Indeed, the role of SMEs is well recognized as an engine of socio-economic development. However, these special entities are increasingly facing problems and constraints in accessing financial resources that hinder their growth and development. The problem of financing of these SMEs is mainly due to their characteristics, which include opacity, information asymmetry and financial fragility. Indeed, the characteristics of small and medium enterprises have been widely recognized in literature as weaknesses and obstacles that reduce and limit their ability to access to external resources. \nIn the current context, small and medium enterprises are increasingly trying to design and develop new strategies and skills in order to gain access to the financial resources. In this respect, a large and growing body of literature focused on social capital development strategies as one of the alternative solutions. Indeed, the relational skills and social capital of managers are fast becoming a key factor that increases SMEs' access to the resources inherent in the social networks to which they belong.\u00a0 \nThe present article is a theoretical review that aims to provide an overview on key concepts and shine new light on the potential impact of managers' social capital on the financial accompaniment of small and medium-sized enterprises. Also, we proposed a conceptual model based on a theoretical framework that draws its origins from the foundations and contributions of the social capital theory and recent empirical works. \n\u00a0 \nJEL Classification: M10 \nPaper type: Theoretical Research","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":244224385,"openaccessinfo":{"externalids":{"MAG":"3203760123","ACL":null,"DOI":"10.5281\/ZENODO.5528979","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Motion and form encoding are closely coupled in the visual system. A number of physiological studies have shown that neurons in the striate and extrastriate cortex (e.g., V1 and MT) are selective for motion direction parallel to their preferred orientation, but some neurons also respond to motion orthogonal to their preferred spatial orientation. Recent psychophysical research (Mather, Pavan, Bellacosa, & Casco, 2012) has demonstrated that the strength of adaptation to two fields of transparently moving dots is modulated by simultaneously presented orientation signals, suggesting that the interaction occurs at the level of motion integrating receptive fields in the extrastriate cortex. In the present psychophysical study, we investigated whether motion-form interactions take place at a higher level of neural processing where optic flow components are extracted. In Experiment 1, we measured the duration of the motion aftereffect (MAE) generated by contracting or expanding dot fields in the presence of either radial (parallel) or concentric (orthogonal) counterphase pedestal gratings. To tap the stage at which optic flow is extracted, we measured the duration of the phantom MAE (Weisstein, Maguire, & Berbaum, 1977) in which we adapted and tested different parts of the visual field, with orientation signals presented either in the adapting (Experiment 2) or nonadapting (Experiments 3 and 4) sectors. Overall, the results showed that motion adaptation is suppressed most by orientation signals orthogonal to optic flow direction, suggesting that motion-form interactions also take place at the global motion level where optic flow is extracted.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":18909857,"openaccessinfo":{"externalids":{"MAG":"2139929378","ACL":null,"DOI":"10.1167\/13.6.16","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1167\/13.6.16","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Information on the content and bioavailability of provitamin A carotenoids, such as beta-carotene, in plant foods is of great interest due to the widespread vitamin A deficiency in developing countries. While the amount of beta-carotene can readily be quantified with analytical techniques, there is limited information on beta-carotene morphology in native plant materials. Here, we introduce nonlinear microscopy for three-dimensional, label-free imaging of carotenoids in fresh and thermally treated plant tissues, providing quantitative information at single-aggregate level and detailed insight into their distribution. Carotenoids in orange-fleshed sweet potato (OFSP), carrot, and mango were visualized by coherent anti-Stokes Raman scattering (CARS) microscopy and, in the case of OFSP, related to the plant-matrix morphology by simultaneous second-harmonic generation (SHG) microscopy of starch granules. Sizes, shapes, densities, and location of different types of carotenoid bodies were quantified. While OFSP and carrot showed heterogeneous rod-shaped bodies with high carotenoid densities indicated by higher CARS signals, the carotenoid-filled lipid droplets in mango appeared as homogeneous low-density aggregates of rounded shape. In addition, beta-carotene densities and morphologies in OFSP were studied after thermal processing, showing that the bodies remain intact despite significant changes of the surrounding starch granules.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":86192408,"openaccessinfo":{"externalids":{"MAG":"2161690481","ACL":null,"DOI":"10.1002\/JRS.2778","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Scientific articles reflect a lot about different forms of university and industry collaborations. Mostly they talk about knowledge transfer and innovation. However, it is also important to pay attention to the inhibiting factors of accepting interns and on the other side examine difficulties that students have in finding internship placement as well as understand internship supervisors? views on the issue. For students internship is a good opportunity to learn job related skills and not necessarily get involved with the company in the future. This article reviews internship program barriers from three perspectives: interns and university supervisors from five Estonian universities and site supervisors from various companies. This study investigates an intern as someone who is in training, who may be paid, but who is a temporary employee (Tovey, 2001); internship as a supplement or complement to academic instruction in environmental science. The data from site supervisors and interns were collected through a web-based questionnaire and universities supervisors were interviewed. Survey was carried out during 2012-2014. The sample consists of 418 interns, 194 institutions providing internship and 24 internship supervisors from universities. The study gives an overview of the situation of internship in Estonia. The data have been discussed in the context of the related literature. Increasing the quality of internship in enterprises in Estonia involves various stakeholders. The author of the present study finds that change can be achieved by coordinated cooperation between stakeholders. In course of cooperation, the best cooperation models and communication meeting mutually agreed aims can be developed.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":56327955,"openaccessinfo":{"externalids":{"MAG":"1594557655","ACL":null,"DOI":"10.20472\/TE.2015.3.1.002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The beginnings of the Portuguese Escudo Monetary Zone (EMZ) in 1961, to promote the economic integration of Portugal and its empire, coincide in time with Mundell's seminal paper about optimum currency areas. If non-optimality was the cause of the EMZ's demise, this would suggest that monetary unions are fragile achievements, with little prospect for survival. The EMZ turned out to be a short-lived experiment, with Angola and Mozambique building up large cumulative deficit positions offset by the sizeable cumulative surpluses of the mainland. A cobweb model using monthly observations for macroeconomic variables of these two territories describes a time divergent process caused by structural imbalances, as well as by the loan granting system. The EMZ was not an optimum currency area and was not sustainable in the long run. This is an historical experiment that is not without interest for the study of other monetary areas.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":234863336,"openaccessinfo":{"externalids":{"MAG":"3154099195","ACL":null,"DOI":"10.1080\/20780389.2021.1890579","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background There is a paucity of data assessing ethnic variations in upper gastrointestinal (GI) disease: we sought to study the incidence of upper GI diseases using adequate measure of ethnicity in Scotland. Methods Using the Scottish health and ethnicity linkage study (SHELS), linking NHS hospital admissions and mortality to the Scottish census 2001, we explored ethnic differences in incidence (2001-2010) of specific upper GI diseases (peptic ulcer disease, oesophagitis, gastritis, gallstones and pancreatitis) in Scotland. Risk ratios (RR) were calculated using Poisson regression with robust variance and multiplied by 100, by gender, adjusted for age and subsequently country of birth. The White Scottish population was the standard reference population (100). 95% confidence intervals (CI) were calculated to enable comparison and exclude 100 in the results below. Results The total numbers of first events within the 9 years period of interest (over almost 29 million of Person-Year (PY) at risk) was 44,612 for peptic ulcer, 102,706 for oesophagitis, 141,235 for gastritis, 87,556 for gallstones and 17,177 for pancreatitis. Looking at risk ratios for all specific upper GI diseases and compared to respectively White Scottish men and women, other White British and other White had a lower risk of upper GI diseases even after adjustment for country of birth. White Irish had an increased risk of upper GI diseases but not significant after adjustment for country of birth. There were consistent ethnic variations in non\u2013White minority ethnic group even after adjustment for country of birth. Chinese men and other South Asian (SA) men and women had a 1.5 to 1.7 fold increased risk of peptic ulcer disease. Pakistani and Bangladeshi had a 1.3 to 2 fold increased risk of oesophagitis whereas Chinese had a lower risk (RR 63.5 [95% CI 50.2, 80.2] for men, 67.4 [51.6, 88.1] for women). South Asian had a 1.2 to 1.5 fold increased risk of gastritis whereas it was lower for men of African origin (65.6 [49.3, 87.3]). Gallstones was more incident in Chinese men (140.2 [117.5, 167.2]) and Pakistani women (131.3 [115,4, 149.4]). The later also had an increased risk of pancreatitis (151.7 [123.3, 186.6]). Conclusion This unique data allowing the comparison of specific upper GI diseases incidences between ethnic groups has shown major differences. Further exploration on risk factors and understanding of differences is needed to promote health equality.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70989906,"openaccessinfo":{"externalids":{"MAG":"1967609739","ACL":null,"DOI":"10.1136\/jech-2013-203126.150","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Labiobaetis sonajuventus n.sp. is described from nymphs collected in a tributary of the Okanogan River in north-central Washington, USA. The new species is distinguished from North American congeners by the well-developed keel between the bases of the antennae, the concave lateral margin of labial palp segment 2, the apically expanded submarginal setae on the labrum, and its western Nearctic distribution.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12545879,"openaccessinfo":{"externalids":{"MAG":"2068980648","ACL":null,"DOI":"10.11646\/zootaxa.3750.1.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.biotaxa.org\/Zootaxa\/article\/download\/zootaxa.3750.1.8\/51547","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Results of treatment of postcolostomy patients are analyzed. In 74.7% cases colostoma was created due to tumor of the rectum or colon, in 6.5% -- due to diverticulosis, in 3.5% -- due to nonspecific ulcerative colitis, Krohn's and other diseases. Complications were diagnosed in 15.2% patients. Surgical treatment was carried out in 714 (43.6%) patients, 568 (79.5%) of them underwent reconstructive surgeries, 146 (20.4%) were operated for stoma complications. New methods of rectal stump preparation for surgery were used: method of differentiation of rectal stump and urether during surgeries, methods of delayed anastomosis. Laparoscopic mobilization of the colon during reconstructive surgeries led to a decrease of surgical trauma and number of complications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11540418,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Arguments for the Q hypothesis have changed little since B. H. Streeter. The purpose of this article is not to advocate an alternative hypothesis but to argue that, if the Q hypothesis is to be sustained, the unlikelihood of Luke's dependence on Matthew must be demonstrated by a systematic and comprehensive reconstruction of the redactional procedures entailed in the two hypotheses. The Q hypothesis will have been verified if (and only if) it generates a more plausible account of the Matthean and Lukan redaction of Mark and Q than the corresponding account of Luke's use of Mark and Matthew.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":55951263,"openaccessinfo":{"externalids":{"MAG":"2156850953","ACL":null,"DOI":"10.1017\/S0028688509990026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In previous investigations we have shown a striking relationship between the activity of glycogenolytic glucose producing acid hydrolases in pancreatic islet tissue and certain insulin-releasing processes. In the present investigation we have studied the relation between islet lysosomal enzyme activities and glucose-induced insulin secretion in vitro in the presence of various insulin secretory inhibitors. It was observed that the nonmetabolizable glucose analogue, mannoheptulose (5 mmol\/l) did induce a 2-fold increase in insulin release at low (1 mmol\/l) glucose, and a total suppression of insulin release at high (16.7 mmol\/l) glucose. These changes in the insulin-secretory pattern were accompanied by similar changes in the activity of islet acid alpha-glucosidase. The activities of neutral alpha-glucosidase (endoplasmic reticulum) or acid phosphatase and N-acetyl-beta-D-glucosaminidase (lysosomes) were not affected by mannoheptulose. 2-Deoxyglucose (5 mmol\/l), another glucose analogue, did not increase insulin secretion or acid alpha-glucosidase activity at low glucose. At high glucose, however, a partial inhibition of both insulin release (approximately 50%) and acid alpha-glucosidase activity was seen. 2-Deoxyglucose slightly suppressed acid phosphatase activity but did not influence the activities of neutral alpha-glucosidase or N-acetyl-beta-D- glucosaminidase. Direct addition of glucose to islet homogenates showed a suppressive effect on alpha-glucosidase activity at pH 4.0 and 5.0. The glucose analogues displayed only marginal (-10%) inhibition of alpha-glucosidase activity at pH 5.0. No effect of the analogues was seen at pH 4.0.(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46861826,"openaccessinfo":{"externalids":{"MAG":"2032926847","ACL":null,"DOI":"10.1159\/000139041","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This article was inspired by the Shangaan sculptor and prophet Jackson Hlungwani who has gained considerable renown all over southern Africa and further afield for his art. Jackson's sculpture is mythical. His communication is mythical. And contact with him makes one realise that faith without a mythical basis becomes - to use Cantwell Smith's distinction - mere religion .... What follows is a clarification of this statement.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":170670522,"openaccessinfo":{"externalids":{"MAG":"1965525942","ACL":null,"DOI":"10.1163\/157430194X00042","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1 Electrophysiological recordings and pharmacological manipulations were used to investigate the mechanisms underlying the generation of action potential burst firing and its postsynaptic consequences in visually identified rat layer 5 pyramidal neurons in vitro. 2 Based upon repetitive firing properties and subthreshold membrane characteristics, layer 5 pyramidal neurons were separated into three classes: regular firing and weak and strong intrinsically burst firing. 3 High frequency (330 \u00b1 10 Hz) action potential burst firing was abolished or greatly weakened by the removal of Ca2+ (n= 5) from, or by the addition of the Ca2+ channel antagonist Ni2+ (250\u2010500 \u03bcm; n= 8) to, the perfusion medium. 4 The blockade of apical dendritic sodium channels by the local dendritic application of TTX (100 nm; n= 5) abolished or greatly weakened action potential burst firing, as did the local apical dendritic application of Ni2+ (1 mm; n= 5). 5 Apical dendritic depolarisation resulted in low frequency (157 \u00b1 26 Hz; n= 6) action potential burst firing in regular firing neurons, as classified by somatic current injection. The intensity of action potential burst discharges in intrinsically burst firing neurons was facilitated by dendritic depolarisation (n= 11). 6 Action potential amplitude decreased throughout a burst when recorded somatically, suggesting that later action potentials may fail to propagate axonally. Axonal recordings demonstrated that each action potential in a burst is axonally initiated and that no decrement in action potential amplitude is apparent in the axon > 30 \u03bcm from the soma. 7 Paired recordings (n= 16) from synaptically coupled neurons indicated that each action potential in a burst could cause transmitter release. EPSPs or EPSCs evoked by a presynaptic burst of action potentials showed use\u2010dependent synaptic depression. 8 A postsynaptic, TTX\u2010sensitive voltage\u2010dependent amplification process ensured that later EPSPs in a burst were amplified when generated from membrane potentials positive to \u201060 mV, providing a postsynaptic mechanism that counteracts use\u2010dependent depression at synapses between layer 5 pyramidal neurons.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31168345,"openaccessinfo":{"externalids":{"MAG":"1967086564","ACL":null,"DOI":"10.1111\/j.1469-7793.1999.00467.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2269673","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Divergence is often ephemeral, and populations that diverge in response to regional topographic and climatic factors may not remain reproductively isolated when they come into secondary contact. We investigated the geographical structure and evolutionary history of population divergence within Sceloporus occidentalis (western fence lizard), a habitat generalist with a broad distribution that spans the major biogeographical regions of Western North America. We used double digest RAD sequencing to infer population structure, phylogeny and demography. Population genetic structure is hierarchical and geographically structured with evidence for gene flow between biogeographical regions. Consistent with the isolation\u2013expansion model of divergence during Quaternary glacial\u2013interglacial cycles, gene flow and secondary contact are supported as important processes explaining the demographic histories of populations. Although populations may have diverged as they spread northward in a ring\u2010like manner around the Sierra Nevada and southern Cascade Ranges, there is strong evidence for gene flow among populations at the northern terminus of the ring. We propose the concept of an \"ephemeral ring species\" and contrast S. occidentalis with the classic North American ring species, Ensatina eschscholtzii. Contrary to expectations of lower genetic diversity at northern latitudes following post\u2010Quaternary\u2010glaciation expansion, the ephemeral nature of divergence in S. occidentalis has produced centres of high genetic diversity for different reasons in the south (long\u2010term stability) vs. the north (secondary contact).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231864063,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/mec.15836","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Marketing is a completely developing paradigm. In spite of nearly metaphysical, esoteric, anti-scientifically approached trends and fashions are increasingly contributing to identify more elements bringing it closer to the science like a technology3. That is, an applied social science by establishing concepts and relations between Strategic and Tactic (operational) issues; its Identification, Creation, Communication and Value-Exchange and Usage- Delivery Processes, and its Functions; this elements, parts or components, and its instruments (tools). Marketing thought and strategic planning become highly outstanding in a world where the so-called servicessimply, intangibles- are progressively weighing in the economical context, inside or outside the capitalist production mode. No matter tangibles or intangibles are merchandized: the dialectic relation between Strategy and Tactics does not change, though particularities in the operational usage of the different variables in the Marketing Mix do. This is another important aspect to keep in mind. It is evident that this work does not correspond to an empiric investigation, but to a theoretical-conceptual position of rupture; that is, a true theory; the exercises of empiric validation that can be undertaken starting from the well norm in the classic or traditional marketing literature, and it is not objective to the present written.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":42309685,"openaccessinfo":{"externalids":{"MAG":"1547048883","ACL":null,"DOI":"10.12691\/JBMS-2-3-1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : This second Volume of the Final Technical Reports summarizes, task- by-task, the technical efforts of the Geometric Modeling Applications Interface Program (GMAP), conducted under U.S. Air Force Contract F33615-85-C-5122. The GMAP Program focused on the computerized generation, control, and exchange of traditional engineering design and manufacturing data. GMAP extended the Product Definition Data Interface Program (PDDI) information model to include computerized support applications for the entire life cycle of a product. GMAP specifically applied product life-cycle support, including engineering, manufacture, inspection, and logistics support, to cooled jet engine turbine blades and disks.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110808782,"openaccessinfo":{"externalids":{"MAG":"2103672442","ACL":null,"DOI":"10.21236\/ada237281","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A shift in emphasis from teaching to learning in the UK higher education sector has resulted in universities considering more efficient learning and teaching strategies. This has included embracing and adopting new technologies, such as the Internet, as an aid to more effective learning and teaching for the student and the teacher. This strategy has not yet been pedagogically proven, however, it is one that many higher education institutions are currently pursuing, or are seriously considering. This article considers the effectiveness of Web-based learning and teaching on a second year unit of a BA (Hons) Accounting degree, and appraises whether it could provide the appropriate medium to create an efficient and robust learning environment for accounting students. The study was implemented as a result of a successful collaborative bid to the university's Learning and Teaching Development Fund, which consisted of staff from Academic Services and the School. Changes in the learning styles (Honey and Mumford, 1992) of students were evaluated and it is suggested that an integrated virtual learning environment, as discussed in this article, could engender a move to more autonomous learning by students.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":144263300,"openaccessinfo":{"externalids":{"MAG":"2064649176","ACL":null,"DOI":"10.1177\/1469787404043810","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Increasing salt intake has substantial negative impacts on health and well-being. This review article focusses on the effect of salinity intrusion (SI) on the water quality and community health of coastal Bangladesh and to find out the effectiveness of interventions for reducing the negative effects of salinity. Saline water is a noteworthy reason for hypertension or high blood pressure in the coastal areas. Health status of women especially the pregnant women are vulnerable because of drinking water sodium (DWS) prompting to pre-eclampsia, high blood pressure and hypertension as well as infant mortality. Several interventions such as rainwater harvesting and Pond sand filter (PSF) system as well as managed aquifer recharge (MAR) usage and the integration of mixed sources were reviewed on the content of drinking water sodium (DWS). Although rainwater has the positive impact of low or no sodium intake on human health, it still possesses negative impacts from not having vital minerals. Despite what might be expected, in MAR a steady increment in sodium concentration through the span of the dry season was observed. It is, subsequently, important to increase awareness about drinking water sodium (DWS) intake by providing and adopting correct technological interventions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":133937013,"openaccessinfo":{"externalids":{"MAG":"2910772101","ACL":null,"DOI":"10.20944\/preprints201901.0066.v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2227-9032\/7\/1\/50\/pdf?version=1553245811","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Patients with schizophrenic spectrum disorders and affective disorders were compared on a reaction time procedure. The nonhospitalized schizotypal subjects performed similarly to the schizophrenic patients on the crossover measure. Mean reaction time discriminated between hospitalized and nonhospitalized patients rather than between types of pathology.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29173483,"openaccessinfo":{"externalids":{"MAG":"2290573112","ACL":null,"DOI":"10.1176\/AJP.144.7.948","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Specialized secretory cells known as goblet cells in the intestine and respiratory epithelium are responsible for the secretion of mucins. Mucins are large heavily glycosylated proteins and typically have a molecular mass higher than 106 Da. These large proteins are densely substituted with short glycan chains, which have many important functional roles including determining the hydration and viscoelastic properties of the mucus gel that lines and protects the intestinal epithelium. In this protocol, we comprehensively describe the method for extraction of murine mucus and its analysis by agarose gel electrophoresis. Additionally we describe the use of High Iron Diamine-Alcian Blue, Periodic Acid Schiff's-Alcian Blue and immune-staining methods to identify and differentiate between the different states of glycosylation on these mucin glycoproteins, in particular with a focus on sulphation and sialylation.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":90649677,"openaccessinfo":{"externalids":{"MAG":"2745173178","ACL":null,"DOI":"10.21769\/BIOPROTOC.2394","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Glioblastoma is a common brain malignancy that tends to occur in older adults and is almost always lethal. The effectiveness of chemotherapy, being the standard treatment for most cancer types, can be improved if a particular genetic sequence in the tumor known as MGMT promoter is methylated. However, to identify the state of the MGMT promoter, the conventional approach is to perform a biopsy for genetic analysis, which is time and effort consuming. A couple of recent publications proposed a connection between the MGMT promoter state and the MRI scans of the tumor and hence suggested the use of deep learning models for this purpose. Therefore, in this work, we use one of the most extensive datasets, BraTS 2021, to study the potency of employing deep learning solutions, including 2D and 3D CNN models and vision transformers. After conducting a thorough analysis of the models' performance, we concluded that there seems to be no connection between the MRI scans and the state of the MGMT promoter.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":246016126,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2201.06086"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present new induction principles for the syntax of dependent type theories. These induction principles are expressed in the internal language of presheaf categories. This ensures for free that any construction is stable under substitution. In order to combine the internal languages of multiple presheaf categories, we use Dependent Right Adjoints and Multimodal Type Theory. Categorical gluing is used to prove these induction principles, but it not visible in their statements, which involve a notion of model without context extensions. We illustrate the derivation of these induction principles by the example of type theory with a hierarchy of universes closed under function space and natural numbers, but we expect that our method can be applied to any syntax with bindings. As example applications of these induction principles, we give short and boilerplate-free proofs of canonicity and normalization for our example type theory. 2012 ACM Subject Classification Theory of computation \u2192 Type theory","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":232013683,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rhythm is the first musical concept deaf people learn in music classes. However, hearing loss limits the amount of information that allows a deaf person to evaluate his or her performance and stay in sync with other musicians. In this paper, we investigated how a visual and vibrotactile music-sensory-substitution device, MuSS-Bits++, affects rhythm discrimination, reproduction, and expressivity of deaf people. We conducted a controlled study with 11 deaf children and found that most participants felt more confident wearing the device in vibration mode even when it did not objectively improve their accuracy. Furthermore, we studied how MuSS-Bits++ can be used in music classes at deaf schools and what challenges and opportunities arise in such a setting. Based on these studies, we discuss insights and future directions that support the design and development of music-sensory-substitution systems for music making.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":5078263,"openaccessinfo":{"externalids":{"MAG":"2795481454","ACL":null,"DOI":"10.1145\/3173574.3174060","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction and hypothesis: Little conclusive data exists regarding Urodynamic (UD) variables predictive of voiding dysfunction after synthetic Midurethral Sling (MUS) placement. This study aims to evaluate outcomes of MUS in female patients with Impaired Detrusor Contractility (IDC), Valsalva Voiding (VV), or both. We propose that there would be no direct relationship between these variables and urinary retention requiring Clean Intermittent Catheterization (CIC) or reoperation at 6 wk follow up. Methods: Retrospective chart review was performed for all MUS procedures at a single institution, 1\/2010- present. Subjects with complete pre-operative UD records and 6 wk follow up were included. The primary outcome measure was urinary retention requiring CIC or re-operation at 6 wk follow up. Results: 187 women who underwent MUS from January 2010 to present had complete UD and \u2265 6 wk follow up data. Average age was 56.7 years. Pre-operative UD identified 64 (34.2%) IDC subjects. At 6-wk follow up, no new subjects in this group required CIC for obstruction or reoperation. No subjects without IDC required CIC or reoperation for urinary retention; however there were 2 reoperations in this group: persistent stress incontinence and vaginal extrusion. Pre-operative UD identified 50 (26.7%) VV subjects. One patient in this group required reoperation; however sling removal was for vaginal extrusion. In the group with both IDC and VV (n=23) no subjects required reoperation. Conclusions: Neither IDC nor VV appear to be risk factors for post-operative urinary retention or reoperation after MUS and have little predictive value for outcomes after MUS.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":75309719,"openaccessinfo":{"externalids":{"MAG":"2317334475","ACL":null,"DOI":"10.4172\/2161-0932.1000236","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Adverse weather conditions, particularly those with low visibility, are critical to the driving tasks. However, the direct relationship between visibility distances and traffic flow\/roadway safety is uncertain due to the limitation of visibility data availability. The recent growth of deployment of Road Weather Information Systems (RWIS) makes segment-specific visibility information available which can be integrated with other Intelligent Transportation System, such as automated warning system and variable speed limit, to improve mobility and safety. Before applying the RWIS visibility measurements in traffic study and operations, it is critical to validate the data. Therefore, an attempt was made in the paper to examine the validity and viability of RWIS visibility data by comparing visibility measurements among RWIS, airport weather stations, and weather information recorded by police in crash reports, based on Ohio data. The results indicated that RWIS visibility measurements were significantly different from airport visibility data in Ohio, but no conclusion regarding the reliability of RWIS visibility could be drawn in the consideration of no verified ground truth in the comparisons. It was suggested that more objective methods are needed to validate the RWIS visibility measurements, such as continuous in-field measurements associated with various weather events using calibrated visibility sensors. Keywords\u2014Low visibility, RWIS, traffic safety, visibility.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":12939582,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Patients with mild intermittent asthma sometimes show signs of inflammation, and guidelines suggesting bronchodilator therapy alone as needed may be questioned. The current study compared as-needed use of a rapid-acting \u03b22-agonist with as-needed use of a \u03b22-agonist and corticosteroid combination as the only medication in asthma patients with intermittent symptoms. A total of 92 nonsmoking asthma patients (of 187 screened) using only an inhaled \u03b22-agonist as needed (28 males, 64 females; mean age 37\u2005yrs; mean forced expiratory volume in one second (FEV1) 101% predicted, mean reversibility 6.5% pred and fractional exhaled nitric oxide (FeNO) \u226520\u2005parts per billion (ppb)) were randomised to treatment with formoterol (Oxis\u00ae Turbuhaler\u00ae) 4.5\u2005\u03bcg as needed (n\u200a=\u200a47) or budesonide\/formoterol (Symbicort\u00ae Turbuhaler\u00ae) 160\/4.5\u2005\u03bcg as needed (n\u200a=\u200a45) in a double-blind, parallel-group 24-week study. The primary variable of efficacy was change in FeNO. Baseline FeNO was 60\u2005ppb and 59\u2005ppb in the budesonide\/formoterol and formoterol groups, respectively. Mean reductions in FeNO in the budesonide\/formoterol and formoterol groups were 18.2\u2005ppb and 2.8\u2005ppb, respectively (95% confidence interval (CI) 7.5\u201323.5\u2005ppb). The reduction in the budesonide\/formoterol group occurred during the first 4\u2005weeks of treatment and remained at this low level. Mean FEV1 increased by 1.8% pred normal value in the budesonide\/formoterol group and decreased by 0.9% pred normal value in the formoterol group (95% CI -4.7\u2013\u2009-0.7). In the budesonide\/formoterol group, use of \u22654 inhalations\u00b7day-1 of study medication was seen on 21 treatment days compared with 74 in the formoterol group. In conclusion, as-needed use of an inhaled corticosteroid together with a rapid-acting bronchodilator may be more beneficial than a \u03b22-agonist alone in patients with intermittent asthma and signs of airway inflammation. The long-term benefits are unknown.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":18077669,"openaccessinfo":{"externalids":{"MAG":"1986739600","ACL":null,"DOI":"10.1183\/09031936.06.00128005","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/erj.ersjournals.com\/content\/erj\/28\/4\/748.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The recognition that physical space (or space-time) is curved is a product of the general theory of relativity, such as dramatically shown by the 1919 solar eclipse measurements. However, the mathematical possibility of non-Euclidean geometries was recognized by Gauss more than a century earlier, and during the nineteenth century mathematicians developed the pioneering ideas of Gauss, Lobachevsky, Bolyai and Riemann into an elaborate branch of generalized geometry. Did the unimaginative physicists and astronomers ignore the new geometries? Were they considered to be of mathematical interest only until Einstein entered the scene? This paper examines in detail the attempts in the period from about 1830 to 1910 to establish links between non-Euclidean geometry and the physical and astronomical sciences, including attempts to find observational evidence for curved space. Although there were but few contributors to \"non-Euclidean astronomy,\" there were more than usually supposed. The paper looks in particular on a work of 1872 in which the Leipzig physicist K. F. Zoellner argued that the universe is closed in accordance with Riemann's geometry.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":118520410,"openaccessinfo":{"externalids":{"MAG":"1536204393","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1205.4909"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A closed \u03bb -term M is easy if, for any\n other closed term N , the lambda theory generated by\n M \u00a0=\u00a0 N is consistent. Recently, it has been introduced\n a general technique to prove the easiness of \u03bb -terms through the\n semantical notion of simple easiness. Simple easiness implies easiness and allows to prove\n consistency results via construction of suitable filter models of\n \u03bb -calculus living in the category of complete partial orderings: given\n a simple easy term M and an arbitrary closed term N , it\n is possible to build (in a canonical way) a non-trivial filter model which equates the\n interpretation of M and N . The question whether easiness\n implies simple easiness constitutes Problem 19 in the TLCA list of open problems. In this\n paper we negatively answer the question providing a non-empty co-r.e. (complement of a\n recursively enumerable) set of easy, but not simple easy, \u03bb -terms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8891059,"openaccessinfo":{"externalids":{"MAG":"1980508492","ACL":null,"DOI":"10.1051\/ita\/2012005","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.numdam.org\/item\/10.1051\/ita\/2012005.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This study carried out migration investigations with different spiked and non-spiked paper and board packaging materials in contact with foodstuffs and food simulants in the temperature range between \u221218\u00b0C and 40\u00b0C. The aim was to deepen the understanding of the migration behaviour of target substances in paper and board fibres. Components and contaminants of paper and board with different molecular weight and chemical structure were selected as target migrants. From the kinetic migration studies, diffusion and partition coefficients were derived by using software for modelling migration in multilayer materials. On the basis of these results, for the first time a model for the migration from paper and board into foods and simulants was developed by adapting the validated diffusion model for plastics. In contrast to the migration in plastic materials, where the migrants are solved and homogeneously distributed in the polymer matrix, mass transfer in paper and board is a more complex phenomenon, because the migrants can be adsorbed on the cellulose surface with different strength. The most important finding of the study was that for a correct modelling of the experimental results in many cases paper and board must be regarded as a two-layer system: the main mass of paper and board (B1) defines the core layer with high diffusion rates, and a thin second layer (B2) represents the surface region of the paper and board with decreased diffusion rates due to the slow desorption.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205948486,"openaccessinfo":{"externalids":{"MAG":"1981232702","ACL":null,"DOI":"10.1080\/19440049.2010.483693","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.archives-ouvertes.fr\/hal-00604875\/file\/PEER_stage2_10.1080%252F19440049.2010.483693.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Nutrition during gestation and early postnatal life can program developmental changes within the reproductive neuroendocrine system that persist until adult life. Here we tested the hypotheses that maternal nutrition during the second and third trimester of gestation and dietary energy intake during the juvenile period interact to affect concentrations of neuropeptide Y (NPY) in the third ventricle cerebrospinal fluid (CSF) after fasting (basal) and in response to peripheral leptin administration in heifer offspring. Bos indicus-influenced beef heifers were developed using a 3 \u00d7 2 factorial arrangement of pre- and postnatal dietary treatments. Beginning at the onset of the second trimester of gestation, pregnant Braford and Brangus cows were fed to reach body condition scores of 7.5\u20138 (H, obese), 5\u20135.5 (M, moderate), or 3\u20133.5 (L; very thin) during the third trimester. Heifer offspring were weaned at ~3.5 mo of age and fed to gain at either a relatively high (H; 1 kg\/d) or low (L, 0.5 kg\/d) rate between 4\u20138 mo of age, then fed a common diet subsequently. A subgroup of pubertal heifers (n = 6\/group) representing 3 of the maternal \u00d7 postnatal groups (HH, MH, and LL) were ovariectomized and received estradiol replacement after puberty. Cannulas were placed surgically in the third ventricle. After at least a 2-wk recovery period, heifers were fasted for 54 h and CSF was collected every 30 min for 5.5 h, including a 30-min basal and 5-h treatment period involving 3 hourly IV injections of recombinant oleptin (0.2 \u00b5g\/kg BW). Basal and post-leptin NPY concentrations in the CSF did not differ (P > 0.10) among LL, MH, and HH heifers. Treatment with leptin had no effect (P > 0.10) on NPY concentration in any group. Therefore, neither the interaction of pre- and postnatal nutrition nor exogenous leptin affected third ventricle NPY tone in this experimental model.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":229436080,"openaccessinfo":{"externalids":{"MAG":"3106885242","ACL":null,"DOI":"10.1093\/jas\/skaa278.667","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7702900","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Multiphase extraction (MPE) was applied as a developed, convenient and efficient method in separation of ephedrine from Pinellia ternata. Firstly, in order to increase the adsorption efficiency, bionic liquid-modified polymer was created. Comparing the effects of all sorbents under variables conditions, the highest amount of 5.8 mg\/g can be adsorbed on dual imidazole ionic liquid modified polymer (Im-Im-Poly) in methanol\/water (70:30, v\/v) solution at 25\u00b0C within 30.0 min. Then the Im-Im-Poly was applied in MPE, after 7 times repetition of extraction, around 1.0 mg\/g of ephedrine from Pinellia ternata was detected. After washing by water, ethanol and methanol, and elution by methanol\/acetic acid (99.0:1.0, v\/v), ephedrine was successfully separated.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":209707298,"openaccessinfo":{"externalids":{"MAG":"2983171994","ACL":null,"DOI":"10.2478\/pjct-2019-0033","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/content.sciendo.com\/downloadpdf\/journals\/pjct\/21\/4\/article-p13.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Depletion of high quality aggregate sources in concert with inflated transportation costs has created a need for utilization of locally available aggregate sources as base materials. Many state specifications, developed only for asphalt concrete surface courses, preclude the use of low quality aggregates that may be suitable for bases in properly designed pavement systems. Paving mixtures containing poorly graded sands from Texas and asphalt cement or emulsified asphalt are evaluated using results from two laboratory tests: (1) resistance to lateral flow (R-value) before and after moisture treatment, and (2) diametral resilient modulus. Ranges of resilient moduli that have provided successful pavements in Texas are presented. Moduli determined in the laboratory have been correlated to moduli collected in the field by in situ deflection testing.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-48":1,"2014-10":1,"unknown":2}},"corpusid":137622241,"openaccessinfo":{"externalids":{"MAG":"1796216298","ACL":null,"DOI":"10.1520\/STP32461S","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The current study sought to generate a theory from the data on crisis management in Islam, and also aimed to identify the strategies used by leaders in the crisis management process. The grounded theory approach was applied, which is one of the qualitative designs. The content of the verses of the Noble Qur'an and the hadiths of the Prophet Muhammad that dealt with the issue of crises were analyzed. The results of the qualitative analysis of the verses of the Qur'an and the hadiths of the Prophet's noble Sunnah have resulted in four concepts that constitute a broad conceptual theory of crisis management according to the Islamic approach. These concepts are: Crisis management strategies in Islam, the stages of crisis management, the characteristics of a leader who manages crises, and the roles of a leader during the crisis management process. A number of assumptions have been made of this generated theory about Islamic crisis management model. In light of the results of this study, recommendations were formulated that indicate the necessity of training leaders in the Islamic approach to crisis management, its strategies and its scientific steps in crisis management. These results have wide applications in the field of training leaders, and also recommend future studies to verify the assumptions of the theory that emerged from the data in this study on crisis management in Islam (COVID\u201019 pandemic crisis as a model).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220251351,"openaccessinfo":{"externalids":{"MAG":"3036212697","ACL":null,"DOI":"10.1002\/pa.2217","PubMedCentral":"7323116","ArXiv":null},"license":"CCBY","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/pa.2217","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Lack of timely reperfusion therapy in patients with ST\u2010elevation myocardial infarction (STEMI) has been associated with worse outcomes. The aim of this study is to identify the frequency and predictors of delayed presentation and missed reperfusion in patients with STEMI in the Gulf Register of Acute Coronary Events (Gulf RACE) registry.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":205639561,"openaccessinfo":{"externalids":{"MAG":"1980310338","ACL":null,"DOI":"10.1002\/clc.20802","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/clc.20802","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Cardiac rupture is a catastrophic complication of acute myocardial infarction with highly mortality rate. Three types of rupture are ventricular free wall rupture( VFR), ventricular septal rupture( VSR), and papillary muscle rupture( PMR). A combination of any 2 types of rupture is called ventricular double rupture (VDR), and very rare. We report a case of VDR (VSR and VFR) after acute myocardial infarction. A 76-year-old female with heart failure was admitted to our hospital. Echocardiography showed an apical VSR and pericardial effusion. She was diagnosed with VDR and emergent operation was performed. During operation, the site of VFR was right ventricle, which was the same infarction area of VSR. VSR was closed by infarction exclusion technique, concurrently excluding the site of VFR. VFR was successfully repaired by mattress sutures. Post-operative course was good without heart failure, though residual shunt was remained. The patient survived and was discharged from our hospital.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2163153,"openaccessinfo":{"externalids":{"MAG":"102705055","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report on the development of fast photon counting x-ray imaging arrays for dual-energy clinical applications. In order to provide the arrays with adequate performance for clinical dual-energy applications, we have designed and fabricated a novel four threshold application specific integrated circuit (ASIC) for single photon counting readout from pixellated direct-conversion CdTe sensors. The ASIC readout and CdTe photon counting detectors are integrated into modules so that the modules can be tiled in one dimension for the fabrication of large area arrays. Recently we have developed novel CdTe arrays which significantly reduce the noise floor allowing for low energy clinical imaging applications. We report on a characterization study of a prototype large area detector which can be used for the generation of two or three dimensional dual energy x-ray absorptiometry (DEXA) images. The prototype CdTe array has 256 pixels with about a 1 mm pitch. We have measured several important detector parameters including the maximum output count rate, energy resolution, and noise performance. A maximum output rate of 0.6 million counts per second per pixel has been obtained with a low noise floor below 7 keV and an energy resolution of 6% at 60 keV. All detector noise counts are less that 7 keV which is sufficiently low for clinical DEXA. Our results demonstrate noise and spectral characteristics that make these x-ray imaging arrays ideally suited for clinical DEXA.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":33431826,"openaccessinfo":{"externalids":{"MAG":"2548646816","ACL":null,"DOI":"10.1109\/NSSMIC.2009.5401581","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The quantification of lacustrine groundwater discharge (LGD) in water is one of the most important indicators of water cycle in lakes by carrying large nutrient loads. The Yasu River is one of the important water sources of Biwa Lake. This paper using Geographic Information System technology, and based on the analysis and prediction of the land use change in Yasu River basin. The water balance was simulated using the Soil and Water Assessment Tool (SWAT2012). Model calibration and uncertainty analysis were performed with sequential uncertainty fitting (SUFI-2). The correlation coefficient and the Nash\u2013Sutcliffe coefficient is higher than 0.50. The results shown that total groundwater accounted for 41.77% of the rainfall and 62.82% of them are shallow groundwater. At the same time, nitrogen and phosphorus are also released to the river with groundwater, continuous impact on the water and water quality of the Biwa Lake.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":133798855,"openaccessinfo":{"externalids":{"MAG":"2803993966","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"be the binary cubic whose coefficients a1, are complex numbers represented on the Argand Plane. Then if its roots are z1, z2, z3, the three corresponding points form the vertices of a triangle A1 A2 A3. Let this triad of points be said to represent the cubic. Then its Hessian is represented by a certain pair of other points; likewise every first polar associates a definite pair of points (z) with any given point (y).","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":122103318,"openaccessinfo":{"externalids":{"MAG":"2161130994","ACL":null,"DOI":"10.1017\/S0013091500036117","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo evaluate the mfVEP test in detection of the optic nerve neuropathy in pituitary tumors.\n\n\nMATERIAL AND METHODS\nWe examined 30 eyes of 15 patients with confirmed by MRI pituitary tumors (7 patients with macroadenomas and 8 patients with microadenomas). In all patients the routine ophthalmologic examination, multifocal visual evoked potentials (mfVEP) and standard static perimetry (central 24-2 threshold), were performed. The control group consisted of 30 eyes of 15 healthy persons.\n\n\nRESULTS\nIn 53% (16\/30) of eyes manifested changes in static perimetry and\/or in mfVEP test. In 13% (4\/30) of eyes abnormal static perimetry and mfVEP were simultaneously observed. The only mfVEP abnormalities were the most frequent feature and were observed in 30% (9\/30) of eyes. Only abnormal static perimetry results were observed in 10% (3\/10) of eyes. In those eyes in related areas of mfVEP recordings the mean peak-to-peak amplitude was significantly reduced compare to the control group. In mfVEP test statistically significant peak-to-peak amplitude reduction was observed in superotemporal quadrants in comparison to the control group (p < 0.009).\n\n\nCONCLUSIONS\nMfVEP can be useful test in the optic nerve dysfunction\/ neuropathy diagnosis in patients with pituitary tumors.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":44809432,"openaccessinfo":{"externalids":{"MAG":"2418638732","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nWe assessed the urinary level of L-FABP in patients with APN and compared between patients with scar versus normal kidneys.\n\n\nMETHODS\nWe enrolled children aged 2 months to 12 years old with APN. The urine concentration of L-FABP and L-FABP\/Cr were measured. Patients divided into three groups; patients with scarring APN as group 1, patients with non-scarring APN as group 2, and controls.\n\n\nRESULTS\n79 children (aged 57.4 \u00b1 40.5 months, (87.5%) female) enrolled in the study. Group 1 was composed of 19 (16 female) cases, group two 35 (32 female) cases, and group three 26 (2 female) healthy controls. There was no significant difference in absolute urinary level of L-FABP between APN groups and controls. Group 1 patients had a significantly higher concentration than group 2 (P < .05). The UL-FABP \/Cr was significantly higher in group 1, than groups 2 and 3 [(0.28 \u00b1 0.39 pg\/mg, 0.08 \u00b1 0.08 pg\/mg, and 0.10 \u00b1 0.09 pg\/mg; respectively), (P < .05, P < .05)]. The difference between group 2 and 3 was not significant (P > .05). The sensitivity and specificity of UL-FABP32 \/Cr ratio in prediction of scar was 50% to 72% and 44% to 56%, respectively.\n\n\nCONCLUSION\nThe urinary ratio of L-FABP to creatinine is not a useful tool for diagnosis of APN or VUR but could be helpful in prediction of long-term potency to renal parenchymal scar formation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":2,"2024-10":1,"2024-18":1}},"corpusid":218491886,"openaccessinfo":{"externalids":{"MAG":"3022254740","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Structural assessment of in-place wood floors is currently limited to inspection of individual members. This is costly and laborious. Consequently, the continued use or adaptive reuse of old\/historic buildings is often in jeopardy because of the lack of an efficient and economical assessment method. A systems approach of assessment is the subject of this research. Floors in four old buildings and several laboratory-built floors were tested. The floor's bending stiffness was determined by static bending tests and its fundamental natural frequency was determined by transverse forced vibration. A model for one way beam action with simple support is the best predictor of floor responses. A technique for using this research to predict stiffness of existing floors is suggested.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":108939886,"openaccessinfo":{"externalids":{"MAG":"1993529208","ACL":null,"DOI":"10.1061\/(ASCE)1076-0431(2007)13:1(30)","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The signal peptide region of preproinsulin (PPI) contains epitopes targeted by HLA-A-restricted (HLA-A0201, A2402) cytotoxic T cells as part of the pathogenesis of \u03b2-cell destruction in type 1 diabetes. We extended the discovery of the PPI epitope to disease-associated HLA-B*1801 and HLA-B*3906 (risk) and HLA-A*1101 and HLA-B*3801 (protective) alleles, revealing that four of six alleles present epitopes derived from the signal peptide region. During cotranslational translocation of PPI, its signal peptide is cleaved and retained within the endoplasmic reticulum (ER) membrane, implying it is processed for immune recognition outside of the canonical proteasome-directed pathway. Using in vitro translocation assays with specific inhibitors and gene knockout in PPI-expressing target cells, we show that PPI signal peptide antigen processing requires signal peptide peptidase (SPP). The intramembrane protease SPP generates cytoplasm-proximal epitopes, which are transporter associated with antigen processing (TAP), ER-luminal epitopes, which are TAP independent, each presented by different HLA class I molecules and N-terminal trimmed by ER aminopeptidase 1 for optimal presentation. In vivo, TAP expression is significantly upregulated and correlated with HLA class I hyperexpression in insulin-containing islets of patients with type 1 diabetes. Thus, PPI signal peptide epitopes are processed by SPP and loaded for HLA-guided immune recognition via pathways that are enhanced during disease pathogenesis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4002964,"openaccessinfo":{"externalids":{"MAG":"2783229888","ACL":null,"DOI":"10.2337\/db17-0021","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/diabetes.diabetesjournals.org\/content\/diabetes\/67\/4\/687.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Finding the right amount of deliberation, between insufficient and excessive, is a hard decision making problem that depends on the value we place on our time. Average-reward, putatively encoded by tonic dopamine, serves in existing reinforcement learning theory as the opportunity cost of time, including deliberation time. Importantly, this cost can itself vary with the environmental context and is not trivial to estimate. Here, we propose how the opportunity cost of deliberation can be estimated adaptively on multiple timescales to account for non-stationary contextual factors. We use it in a simple decision-making heuristic based on average-reward reinforcement learning (AR-RL) that we call Performance-Gated Deliberation (PGD). We propose PGD as a strategy used by animals wherein deliberation cost is implemented directly as urgency, a previously characterized neural signal effectively controlling the speed of the decision-making process. We show PGD outperforms AR-RL solutions in explaining behaviour and urgency of non-human primates in a context-varying random walk prediction task and is consistent with relative performance and urgency in a context-varying random dot motion task. We make readily testable predictions for both neural activity and behaviour.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249096553,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pcbi.1010080","PubMedCentral":"9176815","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/ploscompbiol\/article\/file?id=10.1371\/journal.pcbi.1010080&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We discuss a dynamic procedure that makes fractional derivatives emerge in the time asymptotic limit of non-Poisson processes. We find that two-state fluctuations, with an inverse power-law distribution of waiting times, finite first moment, and divergent second moment, namely, with the power index mu in the interval 2> t(a) yields o=mu-2 . The intermediate time regime is probably incompatible with a picture based on fractional derivatives, or, at least, with a mono-order fractional derivative.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2240063,"openaccessinfo":{"externalids":{"MAG":"1969025947","ACL":null,"DOI":"10.1103\/PhysRevE.70.036105","PubMedCentral":null,"ArXiv":"cond-mat\/0403492"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Radiation intensity and carbon dioxide (CO2) concentration can be precisely controlled to manipulate plant yield and quality. Due to increased plant densities during seedling production, fewer inputs per plant are required, creating the potential to increase production efficiency. Therefore, the objectives of this research were to: 1) quantify the extent radiation intensity and CO2 concentration under sole-source lighting influence morphology and yield of sweet basil (Ocimum basilicum) seedlings, and 2) determine if differences in morphology, yield, and volatile organic compound (VOC) concentration persist after transplant in a common environment. Sweet basil 'Nufar' seedlings were grown in growth chambers with target CO2 concentrations of 500 or 1,000 \u03bcmol\u00b7mol\u20121 under light-emitting diodes (LEDs) providing target photosynthetic photon flux densities (PPFD) of 100, 200, 400, or 600 \u03bcmol\u00b7m\u20122\u00b7s\u20121 for 16 h per day. After two weeks, seedlings were transplanted into a common greenhouse environment and grown until harvest. At transplant and three weeks after transplant (harvest), growth and developmental differences were quantified along with key terpenoid and phenylpropanoid concentrations at harvest. Radiation intensity and CO2 interacted influencing many aspects of plant morphology, though CO2 concentration effects were less pronounced than those of radiation intensity. As radiation intensity during seedling production increased from 100 to 600 \u03bcmol\u00b7m\u20122\u00b7s\u20121, basil seedlings were 38% taller, had a 713% larger leaf area, and had 65% thicker stems; at harvest, plants were 24% taller, had 56% more branches, 28% more nodes, 22% thicker stems, and weighed 80% more when fresh and dry. Additionally, after growing in a common environment for three weeks, eugenol concentration was greater in plants grown under a PPFD of 600 \u03bcmol\u00b7m\u20122\u00b7s\u20121 as seedlings compared to lower intensities. Therefore, increasing radiation intensity during seedling production under sole-source lighting can carry over to increase subsequent yield and eugenol concentration during finished production.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251809466,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pone.0273562","PubMedCentral":"9409542","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0273562&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"One recently reported approach to flat panel autostereoscopic 3D displays under investigation at Sharp Laboratories of Europe Ltd. (SLE) uses a high precision patterned optical half wave retarder combined with a re-configurable output polarizer to 'develop' a parallax barrier structure attached to an LCD display panel. Such a barrier is invisible without the polarizer and thus a 2D\/3D configurable display can be formed. A discussion of cross talk and white level variation in the 3D mode will be made with reference to Fresnel diffraction in the display. A model will be presented and justified in the light of the panel geometry. This model will be compared with measured cross talk, window structure and white level variation in such a 2D\/3D configurable system. The implications that the shape of the transmitting profile has on 3D-display cross talk will be discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122846572,"openaccessinfo":{"externalids":{"MAG":"2067500894","ACL":null,"DOI":"10.1117\/12.430813","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The combustion of municipal solid waste in a boiler for power generation produces a very corrosive environment for the boiler tube materials. The environment contains HCl, SO2 , various metal chlorides and sulfates along with typical combustion products. Due to their low melting points and high vapor pressures, metal chlorides are believed to be primarily responsible for the boiler tube corrosion problems encountered in waste-to-energy (WTE) boilers. Without some sort of corrosion protection method, the standard materials of the construction for the boiler, such as carbon and Cr-Mo steels, are subject to severe high temperature corrosion attack. The present paper discusses the possible modes of high temperature corrosion for waterwalls and boiler tubes in the convection section, and the prevailing protection method for these components as well as the performance of various alloys in these hostile combustion environments.Copyright \u00a9 2004 by ASME","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137664691,"openaccessinfo":{"externalids":{"MAG":"2037207171","ACL":null,"DOI":"10.1115\/NAWTEC12-2214","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract At the beginning of the 1980s there were no modern 1: 50 000 or inch-to-the-mile maps available from the British Geological Survey (at that time named the Institute of Geological Sciences) for the central Lake District, and a good many other areas of Britain too. For the main body of the Lakes, the only official maps were those of Clifton Ward and his colleagues, which were regarded as outmoded not long after they were issued, and were not widely distributed, for each map was individually hand-coloured. These old maps did not even use Lapworth's Ordovician. For the dates of issue, see p. 40. Understandably, the paucity of maps was regarded in some quarters as deplorable. For example, Glasgow Professor Bernard Leake, in a submission to the Study Group on UK Geological Surveying dated 5 December 1985, a copy of which he has kindly made available to me, described the state of affairs at that time as 'dismal and a national disgrace', with 'progress derisory in relation to the backlog'.1 About ninety of the sheet map areas in the UK had last been fully surveyed before 1870, and in some areas of south-central Wales the only 'official' maps went back to 1845! By contrast, France expected to complete its remapping by 1990, having initiated a remapping programme in 1960. The lack of maps was particularly felt by the general public for the Lakes, where so many amateurs wanted to wander the fells and 'see where they were' geologically speaking.2 Needless to","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219218135,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1144\/GSL.MEM.2002.025.01.15","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Hydrogenated amorphous silicon (a-Si:H) offers some technical advantages over crystalline silicon for optical position sensing devices since it can be grown on a large variety of substrates at approximately 250 degrees C, over large areas and at lower cost than crystalline Si. Its transparency to red light makes it suitable for applications which require superimposed detectors. The authors have examined a variety of layered a-Si:H structures using gold or Nichrome resistive contact layers and found that a multiple sequence of n-type\/undoped\/n-type thin films offers the best positional linearity and the minimum change by the Staebler-Wronski effect.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121473751,"openaccessinfo":{"externalids":{"MAG":"2056531595","ACL":null,"DOI":"10.1088\/0022-3727\/21\/2\/018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract. Load calculations play a key role in determining the design loads of different wind turbine components. State of the art in the industry is to use the Blade Element Momentum (BEM) theory to calculate the aerodynamic loads. Due to their simplifying assumptions of the rotor aerodynamics, BEM methods have to rely on several engineering correction models to capture the aerodynamic phenomena present in Design Load Cases (DLCs) with turbulent wind. Because of this, BEM methods can overestimate aerodynamic loads under challenging conditions when compared to higher-order aerodynamic methods - such as the Lifting Line Free Vortex Wake (LLFVW) method \u2013 leading to unnecessarily high design loads and component costs. In this paper, we give a quantitative answer to the question of BEM load overestimation by comparing the results of aeroelastic load calculations done with the BEM-based OpenFAST code and the QBlade code which uses a LLFVW method. We compare extreme and fatigue load predictions from both codes using 66 ten-minute load simulations of the DTU 10 MW Reference Wind Turbine according to the IEC 61400-1 power production DLC group. Results from both codes show differences in fatigue and extreme load estimations for practically all considered sensors of the turbine. LLFVW simulations predict 4\u2009% and 14\u2009% lower lifetime Damage Equivalent Loads (DELs) for the out-of-plane blade root and the tower base fore-aft bending moments, when compared to BEM simulations. The results also show that lifetime DELs for the yaw bearing tilt- and yaw moments are 2\u2009% and 4\u2009% higher when calculated with the LLFVW code. An ultimate state analysis shows that extreme loads of the blade root out-of-plane and the tower base fore-aft bending moments predicted by the LLFVW simulations are 3\u2009% and 8\u2009% lower than the moments predicted by BEM simulations, respectively. Further analysis reveals that there are two main contributors to these load differences. The first is the different treatment in both codes of the effect that sheared inflow has on the local blade aerodynamics and second is the wake memory effect model which was not included in the BEM simulations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":204914543,"openaccessinfo":{"externalids":{"MAG":"2979299406","ACL":null,"DOI":"10.5194\/wes-2019-70","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/wes.copernicus.org\/articles\/5\/721\/2020\/wes-5-721-2020.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The pulse mode of operation for the Nuclear Science Center Reactor (NSCR) was reinitiated in February 1983 using Core VIII. Results of Phase I of the pulse test program were submitted to the USNRC and to the Texas A and M University Reactor Safety Board for review. It was concluded by the NSC management that the roll-off effect observed in fuel temperature and pulse energy for pulses greater than $1.50 was probably due to the prompt neutron lifetime of approximately 16 microseconds associated with FLIP fuel. At that time it was felt that the very short full width at half maximum (FWHM) values associated with the power transients prevented the transient rod from being removed fast enough to keep up with the pulse, and thus, the selected pulse reactivity was not inserted to its full value. It was decided to pursue this idea, and a procedure was developed to monitor both transient rod position and reactor power as a function of time. For each pulse the time for full rod withdrawal was determined and compared to the time at which peak reactor power occurred. The time difference between these two points was observed to decrease as the inserted pulse reactivitymore\u00a0\u00bb increased. Based on this most recent study it appears that pulses on the order of $2.00 would indeed cause reactor power to peak prior to full withdrawal of the transient rod. This is in disagreement with the NSC original report implying that the roll-off above $1.50 was due to rod ejection time. Although the cause of the roll-off at that level has not yet been determined, it is felt that the cause is something other than rod withdrawal times and will be investigated further in the near future.\u00ab\u00a0less","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107503096,"openaccessinfo":{"externalids":{"MAG":"57789708","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Deaf or hard-of-hearing people need support services such as real-time captioning. It is fairly common for captionists to be unable to perform captioning services. In order to address this problem, we proposed a Mobile-type Remote-captioning System. The main characteristic of our system is to use two functions of one mobile phone (e.g. the iPhone 3G\/3GS, Apple Computer, Inc.) at the same time. The two functions are to display the captions input by the captionists (data communications) and to call the captionists to transmit the speaker's speech to the captionists (telephone call). The purpose of our research was to make clear the differences with the existing system, and to discover the advantages and faults of our system. In this study, we investigated these issues using a questionnaire for captionists who had used our system. As a result, we found that our system is suitable for a situation in which the speaker and the deaf or hard-of-hearing person are communicating while walking together (e.g. excursions, plant tours), whether indoors or outdoors. In addition, it reduces the stress that can be caused to deaf or hard-of-hearing children by having adults (captionists) other than teachers in the classroom.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":113056803,"openaccessinfo":{"externalids":{"MAG":"2330668605","ACL":null,"DOI":"10.5136\/LIFESUPPORT.22.146","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Open source drug discovery is increasingly being sought as a solution for managing product development complexities. Three drivers encouraging the use of the open source strategy include: upstream knowledge-based complexities associated with complementary assets, technological complexities given the scale of research and interdependencies between disciplines and downstream commercialization complexities. While literature currently discusses the need for open source strategies and their outcomes, we have reached a critical stage for a framework to cohesively understand how the drivers affect the open source models chosen as well as the governance strategies to ensure a successful outcome both in terms of knowledge access and product development. In this paper, an initial framework is designed with a focus on the type of participant as impacting the motivation to participate in an open source initiative, the objective of any open source strategy as impacting the structural model adopted and the structure of knowledge produced as impacting its management. It is anticipated that this framework should then provide an opportunity to develop governance rules for open source drug discovery initiatives.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24835513,"openaccessinfo":{"externalids":{"MAG":"2122984705","ACL":null,"DOI":"10.1517\/17460441.2010.498815","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The performance of a silicon drift detector (SDD) with an integrated FET, delivered by the company PNSensor, Munich, Germany, was studied in gamma spectrometry at room temperature (23-25degC) with a LaBr3:Ce crystal of 6 mm diameter and 6 mm height. The SDD characteristics were compared with those measured with a Photonis XP5212 photomultiplier, a Large Area Avalanche Photodiode (LAAPD) of Advanced Photonix, Inc., and a Hamamatsu S3590-18 Photodiode (PD). Energy resolution versus gamma ray energies and its components related to the photoelectron\/electron-hole pair statistics and dark noise were measured and compared. At low energies, below 100 keV, the light readout by the photomultiplier gives the best results, while for high energies, above 300 keV, the light readout by the SDD delivers superior energy resolution. In particular, the best energy resolution of 2.7% was determined for 662 keV gamma rays from a 137Cs source.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":35601831,"openaccessinfo":{"externalids":{"MAG":"2158537700","ACL":null,"DOI":"10.1109\/TNS.2008.2005110","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Blood-brain barrier (BBB) dysfunction is prevalent in Alzheimer's disease and other neurological disorders. Restoring normal BBB function through RNA therapy is a potential avenue for addressing cerebrovascular changes in these disorders that may lead to cognitive decline. Although lipid nanoparticles have been traditionally used as drug carriers for RNA, bicelles have been emerging as a better alternative because of their higher cellular uptake and superior transfection capabilities. Cationic bicelles composed of DPPC\/DC7PC\/DOTAP at molar ratios of 63.8\/25.0\/11.2 were evaluated for the delivery of RNA in polarized hCMEC\/D3 monolayers, a widely used BBB cell culture model. RNA-bicelle complexes were formed at five N\/P ratios (1:1 to 5:1) by a thin-film hydration method. The RNA-bicelle complexes at N\/P ratios of 3:1 and 4:1 exhibited optimal particle characteristics for cellular delivery. The cellular uptake of cationic bicelles laced with 1 mol% DiI-C18 was confirmed by flow cytometry and confocal microscopy. The ability of cationic bicelles (N\/P ratio 4:1) to transfect polarized hCMEC\/D3 with FITC-labeled control siRNA was tested vis-a-vis commercially available Lipofectamine RNAiMAX. These studies demonstrated the higher transfection efficiency and greater potential of cationic bicelles for RNA delivery to the BBB endothelium.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260654463,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/pharmaceutics15082086","PubMedCentral":"10459289","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1999-4923\/15\/8\/2086\/pdf?version=1691132419","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Received: November 18, 2016 Revision received: December 26, 2016 Accepted: January 10, 2017 Online First: September 15, 2017 Copyright \u00a9 2017 \uf073 The International Refugee Rights Association \uf073 http:\/\/mejrs.com\/en ISSN 2149-4398 \uf073 eISSN 2458-8962 DOI 10.12738\/mejrs.2017.2.1.0104 \uf073 Winter 2017 \uf073 2(1) \uf073 35-49 Abstract Twice in modern history, Syria and its peoples have experienced massive displacement. First, in the midto late 19th century, Syria received several million forced migrants from the frontiers of the Ottoman Empire; then in the early 21st century, Syria disintegrated into extreme violence, triggering a displacement crisis of massive proportions. The speed with which the country emptied of nearly 10% of its population shocked the world and left the humanitarian aid regime in turmoil as agencies struggled to respond to the growing displacement crisis on Syria's borders. The neighboring states of Turkey, Lebanon, and Jordan were also left in a quandary regarding how to effectively protect these people who were seeking refuge. No country granted the displaced refugee status; each established temporary measures to deal with this crisis. In many cases, neither the displaced nor the host communities were consulted, and thus, tensions quickly emerged among host communities, displaced Syrians, and humanitarian policy makers and practitioners. This study has two aims: first, it sets out to explore how effectively a qualitative, interpretive methodology can be applied to elicit the different perceptions and aspirations of Syria's refugees, humanitarian assistance practitioners, and host communities during the most recent crisis, and second, it seeks to probe what sociohistorical factors related to the host communities might, when circumstances permit, positively contribute to the reintegration of Syrian society post\u2013conflict.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":80168162,"openaccessinfo":{"externalids":{"MAG":"2759291931","ACL":null,"DOI":"10.12738\/MEJRS.2017.2.1.0104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Cryptococcosis is a life-threatening disease often associated with HIV infection. Three Cryptococcus species CYP51 enzymes were purified and catalyzed the 14\u03b1-demethylation of lanosterol, eburicol, and obtusifoliol. The investigational agent VT-1129 bound tightly to all three CYP51 proteins (dissociation constant [Kd] range, 14 to 25 nM) with affinities similar to those of fluconazole, voriconazole, itraconazole, clotrimazole, and ketoconazole (Kd range, 4 to 52 nM), whereas VT-1129 bound weakly to human CYP51 (Kd, 4.53 \u03bcM). VT-1129 was as effective as conventional triazole antifungal drugs at inhibiting cryptococcal CYP51 activity (50% inhibitory concentration [IC50] range, 0.14 to 0.20 \u03bcM), while it only weakly inhibited human CYP51 activity (IC50, \u223c600 \u03bcM). Furthermore, VT-1129 weakly inhibited human CYP2C9, CYP2C19, and CYP3A4, suggesting a low drug-drug interaction potential. Finally, the cellular mode of action for VT-1129 was confirmed to be CYP51 inhibition, resulting in the depletion of ergosterol and ergosta-7-enol and the accumulation of eburicol, obtusifolione, and lanosterol\/obtusifoliol in the cell membranes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":35353512,"openaccessinfo":{"externalids":{"MAG":"2345362039","ACL":null,"DOI":"10.1128\/AAC.00349-16","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. We present simulative and experimental investigations of different coherent receiver designs for high-speed optical intersatellite links. We focus on frequency offset (FO) compensation in homodyne and intradyne detection systems. The considered laser communication terminal uses an optical phase-locked loop (OPLL), which ensures stable homodyne detection. However, the hardware complexity increases with the modulation order. Therefore, we show that software-based intradyne detection is an attractive alternative for OPLL-based homodyne systems. Our approach is based on digital FO and phase noise compensation, in order to achieve a more flexible coherent detection scheme. Analytic results will further show the theoretical impact of the different detection schemes on the receiver sensitivity. Finally, we compare the schemes in terms of bit error ratio measurements and optimal receiver design.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":58558599,"openaccessinfo":{"externalids":{"MAG":"2531461191","ACL":null,"DOI":"10.1117\/1.OE.55.11.111614","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Historians have long recognized post-war Palestine as a society in a state of destabilization. Increasing tension between the population and the Palestine Mandatory government was reflected in political opposition and violence. This was accompanied by the growing role of the United States in the intensive debate on the future of relations between Arabs and Jews, as reflected in the decision in late 1945 to convene the Anglo-American Committee. The transition from a war economy to a period of reconstruction produced immense economic and social problems that added to increasing British debts, which was partly reflected in difficulties in absorbing former servicemen in to Palestine's economy and increasing unemployment of both Arabs and Jews. Destabilization was also made evident by increasing industrial unrest, focusing significantly on the state sector of the economy\u2014the government bureaucracy, the railways, and the military camps. This post-war militancy was part of the economic and social impact of the war, the associated cycle of wartime labor strikes, and the increasing cooperation between Arab and Jewish workers in labor protest against the government.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":159528848,"openaccessinfo":{"externalids":{"MAG":"2202126103","ACL":null,"DOI":"10.1017\/S0020743804364056","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is crucial to develop sensitive and accurate sensing strategies to detect H2O2 and glucose in biological systems. Herein, biocompatible iron-coordinated L-lysine\u2013based hydrogen peroxide (H2O2)-mimetic enzymes (Lys-Fe-NPs) were prepared by precipitation polymerization in aqueous solution. The coordinated Fe2+ ion acted as centers of peroxidase-like enzymes of Lys-Fe-NPs, and the catalytic activity was evaluated via the oxidation of 3,3\u2032,5,5\u2032-tetramethylbenzidine (TMB) by H2O2. Therefore, a sensitive colorimetric detection sensor for H2O2 was constructed with a linear range of 1 to 200 \u03bcM and a detection limit of 0.51 \u03bcM. The same method could also be applied to highly sensitive and selective detection of glucose, with a linear range of 0.5 to 150 \u03bcM and a detection limit of 0.32 \u03bcM. In addition, an agarose-based hydrogel biosensor colorimetric was successfully implemented for visual assessment and quantitative detection of glucose. The design provided a novel platform for constructing stable and nonprotein enzyme mimics with lysine and showed great potential applications in biorelevant assays.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259885252,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/polym15143002","PubMedCentral":"10383789","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-4360\/15\/14\/3002\/pdf?version=1688991536","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We consider multiple imputation (MI) for unbalanced ranked set samples (URSS) by considering them as data sets with missing values. We replace each missing value with a set of plausible values drawn from a predictive distribution that represents the uncertainty about the appropriate value to impute. Using the structure of the MI dataset, we develop algorithms that imitate the structure of URSS to carry out the desired statistical inference. We provide results for the convergence of the empirical distribution functions of imputed samples to the population distribution function, under both URSS and simple random sampling (SRS). We obtain the variances of the imputed URSS, and the expected values of the variance estimators. We also study the problem of quantile estimation using an imputed URSS and propose a hybrid method based on the bootstrap and imputation of URSS data. We apply our results to estimate the mean and quantiles of the mercury in contaminated fish under perfect and imperfect URSS.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":211137976,"openaccessinfo":{"externalids":{"MAG":"3088156612","ACL":null,"DOI":"10.1214\/19-BJPS462","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Shared decision making is a collaborative process intended to develop a treatment plan that considers both the patient's preferences and the health provider's medical recommendations. It is one approach to reducing healthcare disparities by improving patient-provider communication and subsequent health outcomes. This study examines shared decision making about HIV pre-exposure prophylaxis (PrEP) with Black transgender women in Chicago, Illinois, USA, given high prevalence of HIV and disparities in PrEP use. Black transgender women were recruited online and in-person to participate in semi-structured interviews (n\u2009=\u200924) and focus groups (2; n\u2009=\u200914 total), conducted between 2016 and 2017. Iterative thematic content analysis took place. Analysis revealed that internalised transphobia and racism, combined with stigma from service providers, prevented disclosure of gender and sexual identity to providers. Stigma about PrEP as it relates to Black transgender women results in stereotype threat, which undermines patient-provider trust and deters shared decision making for PrEP. Shared decision making promotes cultural competence and humility and builds trust within the patient-provider relationship, leading to better communication and less stigma. The involvement of peers may be one way to mitigate stigma for Black transgender women around PrEP, promote cultural competence within organisations, and empower engagement in shared decision making for HIV prevention.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":234496673,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/13691058.2021.1909142","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13691058.2021.1909142?needAccess=true","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A family of proteins containing a disintegrin and metalloproteinase domain (ADAMs) has been identified recently. Here, we report the identification of a novel member of the ADAM protein family from mouse. This protein is designated ADAM 31. The complementary DNA sequence of ADAM 31 predicts a transmembrane protein with metalloproteinase, disintegrin, cysteine-rich, and cytoplasmic domains. Messenger RNA encoding ADAM 31 was most abundant in testes, but was also detected in many other tissues. More significantly, the antibodies raised against ADAM 31 reveal that the protein has a unique and restricted expression pattern. ADAM 31 is expressed in Leydig cells of the testes, but unlike many other ADAMs, it is not found on developing sperm. Furthermore, ADAM 31 is highly expressed on four types of specialized epithelia: the cauda epididymidis, the vas deferens, the convoluted tubules of the kidney, and the parietal cells of the stomach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263351771,"openaccessinfo":{"externalids":{"MAG":"1992743950","ACL":null,"DOI":"10.1210\/ENDO.141.6.7497","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cassava leave is one type of leaf that has high chlorophyll so it can be used as a natural green dye, but using of it was still limited and needs to develop. This study aimed to determine the effect of the concentration of tween 80 on the characteristic of the pigment powder of cassava leave on foam mat drying method and to proper concentration of tween 80 to get the pigment powder of cassava leave with the best characteristic on foam mat drying method. The research design used was a Completely Randomized Design (CRD) with tween 80 concentration treatment consisting of 5 levels (0%; 0.5%; 1%; 1.5%; 2%). The experiment was repeated three times to obtain 15 experimental units. The data obtained were analyzed by the analysis of variance and if the treatment had a significant effect to variable observed, it was continued with Duncan's Multiple Range Test. The parameters observed in this study included: yield, moisture content, total chlorophyll, solubility and L*, a*, b* values. The results showed that the concentration of tween 80 had a significant effect (P<0,05) on yield, moisture content, total chlorohyll, solubility and L*, a*, b* values. The best treatment was obtained at a concentration level of tween 80 at 1.5% with characteristic: yield of 11.51%, moisture content of 2.08%, total chlorophyll of 6.87 mg\/g, solubility of 85.47%, the L* value of 11.53, the a* value of -38.30, and the b* value of 15.83.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":252537416,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.24843\/itepa.2022.v11.i01.p12","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/doi.org\/10.24843\/itepa.2022.v11.i01.p12","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We have applied the concept of superradiance introduced by Dicke in 1954 to astrophysics by extending the corresponding analysis to the magnetic dipole interaction characterizing the atomic hydrogen 21 cm line. Although it is unlikely that superradiance could take place in thermally relaxed regions and that the lack of observational evidence of masers for this transition reduces the probability of detecting superradiance, in situations where the conditions necessary for superradiance are met (close atomic spacing, high velocity coherence, population inversion, and long dephasing timescales compared to those related to coherent behavior), our results suggest that relatively low levels of population inversion over short astronomical length-scales (e.g., as compared to those required for maser amplification) can lead to the cooperative behavior required for superradiance in the interstellar medium. Given the results of our analysis, we expect the observational properties of 21 cm superradiance to be characterized by the emission of high-intensity, spatially compact, burst-like features potentially taking place over short periods ranging from minutes to days.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":28730845,"openaccessinfo":{"externalids":{"MAG":"2225235405","ACL":null,"DOI":"10.3847\/0004-637X\/826\/2\/216","PubMedCentral":null,"ArXiv":"1601.01717"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One of the key concepts of Construction 4.0 is cyber-physical systems. The construction industry is increasingly creating valuable digital assets, but it is also gradually using digital technology to plan, design, build, monitor, and control the physical ones. This makes construction sites and operations vulnerable to cyber-attacks. While the damage to digital assets can have financial implications, attacks on digitally-controlled physical assets may impact people's well-being and, in worst-case scenarios, result in casualties. The problem is amplified by the emerging cyber-physical nature of the systems, where the human checks may be left out. The construction industry could draw inspiration from the work done in critical infrastructures (CI). Construction is the prelude of any socio-technical asset tagged as a CI. While most assets may not be critical in the CI sense, they are essential to a business' operations and the people directly or indirectly associated with them. This study presents a literature review on the previous CI protection (CIP) efforts and construction cybersecurity studies to show their synergy. Recommendations based on well-established CIP processes to make construction more cyber-secure are provided. It is expected that this study will create awareness about cybersecurity practices within the construction industry. Ongoing work includes understanding where construction stands and developing a framework to address cybersecurity throughout the different project phases.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":249815107,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.36680\/j.itcon.2022.028","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/www.itcon.org\/papers\/2022_28-ITcon-Garcia_de_Soto.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract. The present study was undertaken to provide information about the presence of bacterial flora in the periurethral region of healthy children and its variation with age and sex. It was intended as a basis for subsequent studies in individuals prone to urinary tract infection. Quantitative methods were used for bacteria sampling and culture. The study included 394 girls and 305 boys from birth to 16 years. During the first few weeks of life a massive aerobic bacterial flora (E. coli, enterococci, staphylococci) was established in the periurethral region of both sexes. The colonization with E. coli and enterococci began to diminish already during the first year of life and became very scanty after the age of 5 years. In newborns E. coli colonization was dense in boys and scanty in girls. Later E. coli was the dominating gram\u2010negative species in girls of all age groups. In boys E. coli dominated during the first half year of life, later Proteus was as common as E. coli; staphylococci did not change very much. Urine samples from healthy school\u2010children contained very few gram\u2010negative bacteria, even when collected without preceding cleansing. The results suggest that there might be a local defence mechanism maturing during the first year of life, eventually protecting the exposed area from colonization with gram\u2010negatives and enterococci.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24775732,"openaccessinfo":{"externalids":{"MAG":"2079951978","ACL":null,"DOI":"10.1111\/j.1651-2227.1976.tb04410.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A novel technique for estimating the distribution of the conduction velocity of peripheral nerve fibers is described in this paper. In order to overcome the sensitivity of present methods to noisy data, a regularized-least-squares (RLS) method with a smoothing constraint and a self-adaption of regularization parameter was adopted. The simulation results demonstrated that the improved technique maybe applied in clinical diagnosis because it yielded reliable and almost undistorted results even when the simulated data are severely contaminated by noise.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37139937,"openaccessinfo":{"externalids":{"MAG":"2620009992","ACL":null,"DOI":"10.1109\/10.641337","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Metal halide perovskites are emerging materials for integrated photonics. Here we report a quasi-CW pumped ultra-low ASE\/lasing threshold formamidinium lead bromide (FAPbBr3) laser. The laser achieved stable lasing at 555 nm with a full width at half maximum (FWHM) of 0.6 nm, showing a low lasing threshold of 22.6 \u03bcJ cm\u22122 under 3.5 nanosecond quasi-CW excitation at room temperature. The material also showed an ultra-low ASE threshold of 46 \u03bcJ cm\u22122 under the same pumping condition. Through polymer doping, we showed that the material's performance can be improved by increasing bimolecular recombination rate with reduced grain size.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256273264,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1361-6528\/acb5fb","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Connections between floor slab and shear walls constitute an essential link in the lateral load-resisting mechanism of slab-wall of reinforced concrete building. The ductility performance of wall-slab joint influences the pattern and distribution of lateral forces among the vertical elements of a structure. This study presents the results of an experimental investigation on the ductility performance of wall-slab connection which is designed in accordance to BS 8110. The experiment work includes full-scale test of wall-slab connection under reversible lateral cyclic loading. This study focuses on ductility performance of wall-slab connection under reversible cyclic loading. The hysteresis loops was developed based on experiment data to determine the ductility of wall-slab joint under reversible cyclic loading. The theoretical background was formulated to validate the result of experiment. There was a good agreement between them. Therefore, the ductility of the joint was determined and designed accordingly. The results indicate that the wall-slab connection was governed by brittle failure modes in reinforced concrete. This is due to low ductility which resulted in the inability of the connection to absorb energy efficiently and therefore further undergoes inelastic deformation. In fact, the brittle failure modes did not allow the energy dissipation and lead to sudden failure without warning to the structures as experienced by the Reinforced Concrete (RC) buildings during earthquakes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137712895,"openaccessinfo":{"externalids":{"MAG":"2187987993","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using pooled mean group (PMG) estimation, the article tries to examine the impact of crude oil price, income, primary energy sources, electricity and financial crisis on the demand for crude oil in the six middle-income countries of South Asia over the period of 1988\u20132016, that is, 29 years. The use of PMG estimation enables us to get the short-run and long-run coefficients of comprised variables. Thereafter, dynamic ordinary least squares (DOLS) and fully modified ordinary least squares (FMOLS) panel co-integration techniques are performed to corroborate the outcomes of PMG estimation. Unlike PMG, DOLS and FMOLS panel co-integration methods examine the long-run determinants of oil demand in the presence of heterogeneity. Except for electricity, the coefficients of all other determinants are found in line with the results of PMG. However, the direction of the electricity coefficient is the same in the PMG and DOLS techniques. Therefore, the present study proposes the results of PMG estimation. The results suggest that the demand for crude oil is price inelastic and income elastic in the region. Further, the negative coefficient of electricity confirms that in the long run, electricity acts as a substitute for crude oil. Thus, the extensive use of electricity may help in reducing the demand for crude oil in the South-Asian countries. On the other hand, the primary energy is found complementary to crude oil in the selected countries over the study period. Finally, the coefficient of financial crisis, which is represented by a dummy variable, advocates that the financial crisis has a negative and significant impact on the demand for crude oil in the middle-income countries of South Asia.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":158707805,"openaccessinfo":{"externalids":{"MAG":"2894013723","ACL":null,"DOI":"10.1177\/0972150918795367","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The kinetics of jet-fuel (JP-4) dispersion on water is investigated in laboratory wind tunnels. Evaporation and dissolution rates of various hydrocarbons are determined under varying parameters including air and water temperature, wind speed, humidity, water composition, fuel composition, and fuel-layer depth. Adequate correlations can be made for the kinetics of evaporation of JP-4. While dissolution rates of aromatic components of JP-4 into water could be measured, correlations of the results are difficult because of the complex nature of hydrodynamic effects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":127304479,"openaccessinfo":{"externalids":{"MAG":"98619355","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1,3-Cyclohexanediol was prepared through multiphase-catalytic hydrogenation of resorcinol. The influences of solvent, catalyst, reaction-temperature and reaction-time on the yield of 1,3-cyclohexanediol and the conversion of resorcinol are studied. The result show that the function of catalytic hydrogenation of stable nickel is remarkably better than that of reductive-iron powder and palladium; the catalytic hydrogenation reaction goes on well in the polarity solvent, while it almost dose not take place in the non-polarity solvent; and the reaction-temperature should not be too high and the time should not be too long because 1,3-cyclohexanediol can be further converted into some byproducts such as cyclohexanol, the reaction-temperature should not be too high and the time should not be too long.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209679866,"openaccessinfo":{"externalids":{"MAG":"2467964050","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study explores the use of several non-parametric statistical tests for evaluating the performances of computer vision algorithms, specifically corner detectors, as a more reliable alternative to the graphical approaches that have been commonly employed to date. Using synthetic images carrying corners of different internal angles and orientations and a carefully designed testing framework, a ranking of the performances of corner detectors was established. It was found that Harris & Stephens and SUSAN out-performed more modern detectors. These are one of the few examples where evaluation of vision operators independent of the application has predicted performance in a real-world problem. A similar exercise on real images of the same patterns produced similar results and the findings of a real-world application that uses corners to identify signage were also consistent. Together, all of the tests considered essentially perform pairwise comparisons of performance, so when many algorithms are involved it is important to take account of the potential for type I statistical errors. Several approaches were evaluated and none were found to affect the conclusions.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":52298458,"openaccessinfo":{"externalids":{"MAG":"2800533312","ACL":null,"DOI":"10.1049\/iet-cvi.2017.0256","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this study we analyzed a commercial dietary fiber blend known as Fiber-Plus and a dietary fiber mixture (DFM) prepared in our lab (10% apple pectin, 10% orange pectin, 36% locust bean gum and 44% corncob composed of 56% fiber). DFM provided greater inhibition of starch digestion and glucose absorption (p < 0.05) than did Fiber-Plus. DFM was also found to be significantly more efficient (p < 0.05) than Fiber-Plus at reducing the glycemic response following starch loading. Rats fed DFM or corncob demonstrated a much lower glycemic response following a test meal as compared to those fed a fiber-free diet. Both fiber sources decreased fasting cholesterol and triglyceride concentrations; transit time was shortened and fecal values were higher than those of controls. beta-glucuronidase activity in intestinal segment contents and feces was lower in rats fed fiber. We conclude that DFM is effective in controlling plasma glucose and lipid levels. Corncob, a novel fiber source, could be beneficial in the treatment of gastrointestinal tract disorders and in the elimination of carcinogenic elements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19414589,"openaccessinfo":{"externalids":{"MAG":"2335543067","ACL":null,"DOI":"10.1080\/07315724.1993.10718357","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"To evaluate use of a digital photostimulable phosphor imaging system in the neonatal nursery, 150 newborns were divided into three groups of 50. In the first two groups, screen-film and computed radiographs of the chest were obtained at the same radiation exposure; in the third group, computed radiographs were obtained with a 50% dose reduction (half-exposure computed radiographs). All images were blindly evaluated by three readers who scored the quality of visualization of the mediastinum, lung, bone, soft tissues, and endotracheal and nasogastric tubes, and also image density. No statistical differences in visualization of tubes existed among the three groups. Visualization of the mediastinum, lung, bones, and soft tissues was statistically significantly better on computed radiographs than on half-exposure computed radiographs; visualization of the lungs, bones, and soft tissues was statistically significantly better on screen-film radiographs than half-exposure computed radiographs. Image density was statistically better on computed and half-exposure computed radiographs than on screen-film radiographs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26378611,"openaccessinfo":{"externalids":{"MAG":"1995633006","ACL":null,"DOI":"10.1148\/RADIOLOGY.181.3.1947105","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Biological warfare has been a threat to society for many decades. This article summarises some of the most likely organisms suitable for a bio-terrorist attack, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, the agents of viral haemorrhagic fevers, Variola virus and botulism toxin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85279632,"openaccessinfo":{"externalids":{"MAG":"2047959465","ACL":null,"DOI":"10.1080\/20786204.2004.10873130","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1080\/20786204.2004.10873130","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo isolate the collagen phagocytic subpopulation of fibroblast (CPSF) and non-collagen phagocytic subpopulation of fibroblast (nCPSF) and to identify their differentially expressed genes.\n\n\n\nMETHODS\nThe CPSF and nCPSF was isolated by using collagen-fluorescein-isothiocynate-latex bead (COL-FITC-LB) phagocytosis technique and FCM sorting method. Microarray analysis was used to screen the differentially expressed genes, which were verified by real-time PCR. \n\n\n\nRESULTS\nCPSF and nCPSF was successfully isolated. Seventeen differentially expressed genes were identified. Compared with nCPSF, the expression of 12 or 5 genes was up-regulated or down-regulated in CPSF. Three of the 12 up-regulated genes were urokinase plasminogen activator receptor-associated protein (uPARAP), cytochrome b-245, beta polypeptide (CYBB) and Hook homolog 1 (HOOK1), which were confirmed by real-time PCR. uPARAP mRNA expression level in CPSF was 2788 times of that in nCPSF. CYBB mRNA expression in CPSF was only 0.85 times of that in nCPSF. HOOK1 mRNA expression in CPSF was 1.96 times of that in nCPSF (P<0.05). \n\n\n\nCONCLUSION\nA novel method is successfully established to isolate CPSF and nCPSF. uPARAP is the main differentially expressed gene in CPSF and nCPSF, which is obviously involved in the fibroblast collagen phagocytosis. It might be a potential biomarker for treatment of collagen diseases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21992135,"openaccessinfo":{"externalids":{"MAG":"2389332561","ACL":null,"DOI":"10.11817\/j.issn.1672-7347.2015.06.006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Repeating earthquakes (repeaters) are events that recurrently rupture the same fault patch with nearly identical magnitudes. Although repeaters have been widely studied and utilized in many fields over the last four decades, there are no standard criteria for reliably identifying such events. The current criteria adopted in the geophysical research community are inconsistent and difficult to justify. Different criteria may inescapably incur inadequate hypotheses and lead to controversial interpretations, highlighting the urgent need for seeking a uniform approach to reliably identify repeaters. In this study, we address this long-standing issue by deriving the most logical criteria on the basis of theoretical calculation with simple yet reasonable assumptions. Quantitatively, we define a repeating pair if their interevent distance is \u226480% of the rupture area of the larger event and their magnitude difference is \u22640.3. We demonstrate the superiority of our proposed approach with challenging cases in California, and our results shed new insight into the hierarchical fault structures in the source areas. Although this study focuses on defining repeating earthquakes, the application to repeating seismic events in other planetary bodies such as moonquakes and marsquakes is straightforward, potentially help avoid misinterpretations of the physical processes in both Earth and planetary interiors.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":261417741,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1785\/0220230124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract The cubic translation model is a well know tool in wind engineering, which provides a mathematical description of a non-Gaussian pressure as a cubic transformation of a Gaussian process. This simple model is widely used in practice since it offers a direct evaluation of the peak factors as a function of the statistics of the wind pressure data. This transformation is rather versatile but limited to processes which are said to be in the monotonic region. For processes falling outside this domain, this paper describes an alternative which is based on the physics of the wind flow. First, it is shown, with a classical example of a flow involving corner vortices on a flat roof, that the pressure data which does not meet the monotonic criterion is in fact associated with a bimodal distribution. Then, the proposed approach is to decompose this data into the two governing modes (slow background turbulence and fast corner vortices) and apply the usual translation model to each of them.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":199273574,"openaccessinfo":{"externalids":{"MAG":"2958724769","ACL":null,"DOI":"10.2478\/mmce-2019-0006","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/orbi.uliege.be\/bitstream\/2268\/238033\/1\/2NCWE_Full%20paper_Rigo_et_al..pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A procedure to design axially symmetric Cassegrain or Gregorian dual-reflector antennas from various combinations of prescribed geometric parameters is presented. From these input parameters, the overall geometry of the antenna is derived in closed form. This procedure can be used as the starting point of a synthesis procedure, where both main reflector and subreflector are shaped to create the desired aperture field distribution.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110388142,"openaccessinfo":{"externalids":{"MAG":"2084593128","ACL":null,"DOI":"10.1109\/74.683545","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper studies the spaces of representations of knot groups into a linear group , their categorical factor-spaces (i.e., the spaces of all characters of the representations), and their cohomology-jump subspaces. Connections are established between the latter and the spaces of representations of dimension one greater. A complete description is given of these spaces for 2-bridge knots.Bibliography: 12 titles.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123465462,"openaccessinfo":{"externalids":{"MAG":"2092436923","ACL":null,"DOI":"10.1070\/SM1994V078N01ABEH003464","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The level of slope influenced by the condition of the rocks beneath the surface. On high level of slopes, amount of surface runoff and water transport energy is also enlarged. This caused by greater gravity, in line with the surface tilt from the horizontal plane. In other words, topsoil eroded more and more. When the slope becomes twice as steep, then the amount of erosion per unit area be 2.0 - 2.5 times more. Kuok and surrounding area is the road access between the West Sumatra and Riau which plays an important role economies of both provinces. The purpose of this study is to map the locations that have fairly steep slopes and potential mode of landslides. Based on SRTM data obtained,\u00a0 the roads in Kuok area has a minimum elevation of + 33 m and a maximum\u00a0 + 217.329 m. Rugged road conditions with slope ranging from 24.08 \u00b0 to 44.68 \u00b0 causing this area having frequent landslides. The result of slope stability analysis in a slope near the Water Power Plant Koto Panjang, indicated that mode of active failure is toppling failure or rock fall and the potential zone of failure is in the center part of the slope.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":132046329,"openaccessinfo":{"externalids":{"MAG":"2590457277","ACL":null,"DOI":"10.24273\/jgeet.2016.11.5","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/journal.uir.ac.id\/index.php\/JGEET\/article\/download\/5\/6","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"One of the most challenging aspects of game AI implementation in computer games is in the production of artificial opponents that can demonstrate human-intuitive strategic skills. In this paper, the need and requirements for a quick and efficient method to capture these skills are identified. Based on these requirements, a framework for a game AI shell is proposed. A case study is presented to demonstrate the workability of the framework by employing a prototype shell to generate a game AI middleware for a tabletop strategy-base game.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":23601703,"openaccessinfo":{"externalids":{"MAG":"2013831947","ACL":null,"DOI":"10.1145\/1306813.1306836","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Gene expression programming (GEP) is a genotype- phenotype system with non-coding regions in genome where possible neutral mutations would be accumulated. In this paper, a novel concept named naive gene expression programming (NGEP) is introduced. The main contributions include: (a) proposing a novel algorithm named NGEP, which decoding method based on the complete tree, (b) discussing the role of genetic neutrality in GEP and NGEP, and (c) performing experiments to show that NGEP is faster than traditional GEP, and the success rate of NGEP is higher than that in traditional GEP.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15215931,"openaccessinfo":{"externalids":{"MAG":"2009113927","ACL":null,"DOI":"10.1109\/WICOM.2008.2602","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Self-heating is a crucial effect in integrated nanophotonic devices regarding their power consumption. In this work, we employ coupled 3D thermo-electrical simulations to gain insight into the thermal behavior related to traps in a monolithic InP-InGaAs-InP pin-diode fabricated at IBM-Research Zurich. From transport study, two types of defects are found to be very likely present in the studied device: (i) positive oxide charges close to the interface between III-V materials and top oxide layer and (ii) electron-type traps at the p-InP\/i-InGaAs interface. Thermal simulations show that the presence of electron-type traps at the p\/i interface enhances the self-heating in the device","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":249106752,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1117\/12.2620298","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The diversity of cytodifferentiation in a transplantable rat pancreatic acinar carcinoma provides a biological model system for the study of regulatory molecular events that differ from those in normal acinar cells. Secretory (zymogen) granule proteins and granule membranes of neoplastic and normal pancreatic acinar cells were compared to determine the differences in gene expression between apparently well-differentiated secretory granule-containing neoplastic cells and normal cells. Nineteen proteins observed in two-dimensional polyacrylamide gels of normal secretory granule extracts were seen also in tumor granule extract profiles, with reduced but detectable amounts of lipase and four basic proteins. In addition, tumor granule extracts contained a new protein of Mr 24,000, designated p24, which was not detectable in normal extracts. Neoplastic granule membranes, while having phospholipid composition similar to that of normal membranes, lacked or contained a greatly reduced amount of a major glycoprotein of Mr 80,000 and three other proteins of Mrs 50,000, 37,000, and 36,000. The nature of p24 protein in secretory granule extracts and the significance of the reduction or absence of Mr 80,000 membrane glycoprotein in this tumor remain to be elucidated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2325743,"openaccessinfo":{"externalids":{"MAG":"2075780776","ACL":null,"DOI":"10.1073\/PNAS.80.14.4379","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: End-stage renal disease is a major health problem worldwide nowadays. Although conventional hemodialysis is the most widely used modality, short daily hemodialysis has been proposed as a more physiologic treatment. The objective of this article is to compare the quality of life of patients on each hemodialysis modality. Methods: A multicentric cross-sectional study was performed in 9 Spanish hospitals. Patients treated for at least 3 months with conventional or short daily hemodialysis were included and quality of life measured using the Euroqol-5D quality of life questionnaire. Bayesian models were used for analyzing quality of life results. Results: Ninety-three patients were included, 27 were on daily hemodialysis and 66 on conventional hemodialysis. All models demonstrated a better quality of life for daily hemodialysis versus conventional hemodialysis. Only 14% of the patients on conventional hemodialysis were willing to change to a daily schedule. Conclusions: Short daily hemodialysis shows a better quality of life than conventional hemodialysis with all Bayesian approaches considered.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":45522004,"openaccessinfo":{"externalids":{"MAG":"1994693750","ACL":null,"DOI":"10.1159\/000227784","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Twenty five patients with grade one and grade two bleeding internal hemorrhoids were treated with infrared photocoagulation. This study did not compare the different methods of treatment, however the results do support the contention that infrared photocoagulation is an effective, safe method of treatment for low grade bleeding internal hemorrhoids.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29673581,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SUMMARY: A phage-induced enzyme has been used to hydrolyse the exopolysaccharides prepared from nine Klebsiella serotype 2 strains. In each case, the major product was a tetrasaccharide with chemical composition corresponding to the carbohydrate repeating unit of the polysaccharide. The tetrasaccharides also contained formate, sometimes with acetate or pyruvate. As the terminal reducing sugar in each tetrasaccharide was mannose, the enzyme is a mannosidase hydrolysing the d-mannosyl 1 \u2192 4 d-glucose linkage.\nThe enzyme is highly specific, being inactive against carboxyl-reduced type 2 polysaccharide and against polysaccharides from a number of other Klebsiella strains of different serotype. In contrast, similar phage-induced enzymes from Klebsiella aerogenes serotype 54 strains hydrolyse both type 2 and type 54 polysaccharides, yielding the same products from type 2 material as does the homologous enzyme. No further polysaccharides among those currently tested acted as substrates for the phage-induced enzymes.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":20766469,"openaccessinfo":{"externalids":{"MAG":"2044016655","ACL":null,"DOI":"10.1099\/00221287-70-2-331","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1099\/00221287-70-2-331","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Deregulation of apoptosis seems to be a hallmark of the Fanconi anemia (FA) syndrome. In order to further define the role of the FA protein from complementation group C (FAC) in apoptosis, we characterized parameters modified during the mitomycin-C (MMC)-induced apoptotic program. It is shown that despite a higher level of cell death for FA compared to normal lymphoblasts after MMC treatment, FA cells do not display a marked DNA fragmentation. Furthermore, while playing a central role in MMC apoptosis of normal lymphoblasts, the activity of caspase-3-like proteases is altered in FA cells. Interestingly, the disruption of the mitochondrial transmembrane potential (Deltapsi), an early event that can lead to apoptotic or to necrotic death, is accomplished similarly in FA and in normal cells. Finally, it is shown that the overexpressed FAC protein inhibited the apoptotic steps, with the exception of the decrease of the Deltapsi. Altogether, our results indicate that the FAC protein acts at a step preceding the activation of the caspases and after the modification of the Deltapsi, a decision point at which cells can be pushed toward either apoptosis or necrosis and which, consequently, regulates the balance between the two modes of cell death.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28875820,"openaccessinfo":{"externalids":{"MAG":"2073271130","ACL":null,"DOI":"10.1006\/EXCR.1998.4316","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The distribution of non-ant arthropods was examined in 40 urban habitat fragments in coastal San Diego County, California, USA, to look for effects of fragmen- tation, proximity to developed edge, and the non-native Argentine ant (Linepithema humile). Arthropods were sampled with pitfall traps and by vacuum sampling from California buck- wheat shrubs (Eriogonumfasciculatum). Individual arthropods were identified to order and Recognizable Taxonomic Unit (RTU), or morphospecies. At the fragment scale we looked for correlations in the point diversity and abundance of arthropods as a function of the age and area of the fragment being sampled. At the scale of the individual sample points we looked for correlations of abundance and diversity with variables that describe the species composition of the shrub vegetation and disturbance. As indicators of disturbance we used the cover of native woody and exotic non-woody vegetation, the distance to the nearest developed edge, and the abundance of Argentine ants. The following patterns were found: (1) In general, arthropods showed a fragmentation effect with point diversity and abundance positively correlated with fragment area and negatively correlated with fragment age. (2) The pitfall samples were dominated by three primarily non-native orders, Isopoda (pillbugs), Dermaptera (earwigs), and Blattaria (roaches). Over 35% of all pitfall-captured arthropods belonged to four species in these orders. Dermaptera and Blattaria increased in abundance in smaller and older fragments, respectively. Isopod abundance, in contrast, was unrelated to fragment attributes. None of these groups appeared to be associated with edges, but were distributed throughout the fragments. (3) Point diversity and abundance in ground-active spiders appears to be enhanced by fragmentation. (4) Total pitfall RTU richness and abun- dance, and abundance or richness in the Coleoptera (vacuum), Diptera, non-ant Hymenop- tera, Hemiptera, Microcoryphia, and Acarina had significant partial negative correlations with Argentine ant abundance. The Diptera and Coleoptera had this negative partial rela- tionship with the Argentine ants despite the fact that both they and the ants were positively associated with edges. (5) In general, diversity in most orders was higher in sampling locations dominated by coastal sage scrub habitat than in those with appreciable cover of chaparral shrub species. (6) There was a strong seasonal variation in abundance and diversity in most orders. Diversity and abundance were highest in spring, intermediate in winter, and lowest in the fall. (7) Although higher trophic levels are often considered to be more sensitive to fragmentation, two groups of arthropod predators, spiders and carabid beetles, increased in abundance in older fragments. Abundance of these predators was positively correlated with the abundance of Argentine ants and the non-native Isopods, Dermaptera, and Blattaria.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":14652420,"openaccessinfo":{"externalids":{"MAG":"2018795507","ACL":null,"DOI":"10.1890\/1051-0761(2000)010[1230:AIUHFI]2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of thermal modulation techniques provides powerful tools to enhance and influence the selectivity and sensitivity of metal oxide based functional layers in gas sensing applications. However, when using micromachined, low-power consuming, so-called hotplate devices, the determination of the absolute temperature of the sensitive layer still presents a challenge. In this contribution, a novel method based on a phase transition in thermally sensitive materials is applied to determine the absolute temperature with high accuracy. The technique relies on depositing small, well-defined amounts of various materials with high spatial resolution using an inkjet printer and then establishing the relation between the heater's resistivity and the absolute temperature when the phase transition occurs. With this approach, the spatial distribution of the absolute temperature of microelectromechanical systems can be achieved. Due to the flexibility of inkjet printing, the presented method may be applied to a wide range of scenarios. [2018\u20130021]","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":44137780,"openaccessinfo":{"externalids":{"MAG":"2797644929","ACL":null,"DOI":"10.1109\/JMEMS.2018.2822874","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The 2006 June 12 occultation of the star P384.2 (2UCAC 26039859) by Pluto was observed from five sites in southeastern Australia with high-speed imaging photometers that produced time-series CCD images. Light curves were constructed from the image time series and fit by least-squares methods with model light curves. A new modeling procedure is presented that allows a simultaneous fit of the atmospheric parameters for Pluto and the astrometric parameters for the occultation to all of the light curves. Under the assumption of a clear atmosphere and using this modeling procedure to establish the upper atmosphere boundary condition, immersion and emersion temperature profiles were derived by inversion of the Siding Spring light curve, which had our best signal-to-noise ratio. Above \u223c1230 km radius, atmospheric temperatures are \u223c100 K and decrease slightly with altitude\u2014the same as observed in 1988 and 2002. Below 1210 km, the temperature abruptly decreases with altitude (gradients \u223c2.2 K km-1), which would reach the expected N2 surface-ice temperature of \u223c40 K in the 1158-1184 km radius range. This structure is similar to that observed in 2002, but a much stronger thermal gradient (or stronger extinction) is implied by the 1988 light curve (which shows a \"kink\" or \"knee\" at 1210 km). The temperature profiles derived from inversion of the present data show good agreement with a physical model for Pluto's atmosphere selected from those presented by Strobel et al. (1996). Constraints derived from the temperature profiles (and considering the possibility of a deep troposphere) yield a value of 1152 \u00b1 32 km for Pluto's surface radius. This value is compared with surface-radius values derived from the series of mutual occultations and eclipses that occurred in 1985-1989, and the limitations of both types of measurements for determining Pluto's surface radius are discussed. The radius of Pluto's atmospheric shadow at the half-intensity point is 1207.9 \u00b1 8.5 km, the same as obtained in 2002 within measurement error. Values of the shadow radius cast by Pluto's atmosphere in 1988, 2002, and 2006 favor frost migration models in which Pluto's surface has low thermal inertia. Those models imply a substantial atmosphere when New Horizons flies by Pluto in 2015. Comparison of the shape of the stellar occultation light curves in 1988, 2002, and 2006 suggests that atmospheric extinction, which was strong in 1988 (15 months before perihelion), has been dissipating.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":37224008,"openaccessinfo":{"externalids":{"MAG":"2031013916","ACL":null,"DOI":"10.1086\/517998","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1086\/517998\/pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In this paper I will discuss and criticize the concept \"second naivite\" from the perspective of the late modern Swedish society. My point of departure is the \"existential epidemiology\" that characterizes the Swedish context (DeMarinis, 2003; see also Bauman, 1993 and Giddens 1990). Late modern societies like Sweden face serious psychological health problems in relation to the existential dimension. The rapid intellectual development of the last centuries has led into a blind alley, when it comes to existential issues.In relation to this, the concept second naivite, first introduced by James Fowler, has become popular among contemporary psychologists of religion (Fowler, 1995). The concept suggests a possibility for an individual religiosity beyond reason, and thus beyond the late modern dilemma. Scholars like Streib and Wulff develop and apply the concept almost like a vision of mature and healthy religiosity (Streib, 2001; Wulff, 1997), whereas Dezutter, Soenens and Hutsebaut test it in relation to the empirical setting of Belgium (Dezutter; Soenens & Hutsebaut, 2005).The concept represents a creative and challenging view of religiosity important for the scholarly discussion of late modern religiosity. However, in relation to the Swedish late modern context, the concept has important shortcomings. The concept builds on the idea of a common religious socialization. In Sweden, this is no longer the case. This makes the question of religious development in terms of a second naivite a much more complicated issue than hitherto recognized. Revealing the weaknesses in relation to the Swedish late modern context I will suggest an alternative understanding of the concept. This will be based on Winnicott's object relations theoretical concept of play, and its role for human health and creativity (Winnicott, 1971). The discussion will be illustrated by examples from an experimental ritual project within contemporary Sweden.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":141612682,"openaccessinfo":{"externalids":{"MAG":"318696631","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cellular connectivity for drones comes with a wide set of challenges as well as opportunities. Communication of cellular-connected drones is influenced by 3-dimensional mobility and line-of-sight channel characteristics which results in higher number of handovers with increasing altitude. Our cell planning simulations in coexistence of aerial and terrestrial users indicate that the severe interference from drones to base stations is a major challenge for uplink communications of terrestrial users. Here, we first present the major challenges in co-existence of terrestrial and drone communications by considering real geographical network data for Stockholm. Then, we derive analytical models for the key performance indicators (KPIs), including communications delay and interference over cellular networks, and formulate the handover and radio resource management (H-RRM) optimization problem. Afterwards, we transform this problem into a machine learning problem, and propose a deep reinforcement learning solution to solve HRRM problem. Finally, using simulation results, we present how the speed and altitude of drones, and the tolerable level of interference, shape the optimal H-RRM policy in the network. Especially, the heat-maps of handover decisions for different altitudes\/speeds of drones have been presented, which promote a revision of the legacy handover schemes and boundaries of cells in the sky.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":210859337,"openaccessinfo":{"externalids":{"MAG":"3040137968","ACL":null,"DOI":"10.1109\/VTC2020-Spring48590.2020.9129453","PubMedCentral":null,"ArXiv":"2001.07937"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Concentrations of chlorinated pesticides and polychlorinated biphenyls (PCBs) were determined in mussels (Mytilus galloprovincialis) and goby fish (Gibius sp.) collected in four areas located in eastern coastal waters of the middle and north Adriatic Sea. Most samples were collected in early spring and late summer of 1974 and 1975. The compounds p,p'-DDT, p,p'-DDE, p,p'-TDE, and PCBs were detected most frequently. In about 60 percent of the samples dieldrin was also detected. Average wet-weight concentrations of sigmaDDT and PCBs in mussels from the four areas sampled were: Istrian coast, 65 and 76 ppb; Rijeka Bay, 58 and 75 ppb; Zadar, 36 and 128 ppb; Losinj Island, 167 and 133 ppb. Average concentrations in fish samples were: Istrian coast, 124 and 144 ppb; Rijeka Bay, 37 and 82 ppb; Losinj Island, 166 and 157 ppb. Dieldrin concentrations were in the low ppb range. Although major Italian rivers discharge chlorinated hydrocarbons into the north Adriatic, sampling of biota from Istrian coastal waters indicates no significant effect on the pollution level. However, waste waters from small coastal settlements evidently do contribute significantly to chlorinated hydrocarbon contamination of that ocean. Marine samples from Losinj Island had high chlorinated hydrocarbon concentrations, indicating uptake of pollutants from the north Adriatic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5883507,"openaccessinfo":{"externalids":{"MAG":"2467889367","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: This study was designed to explore the stage distribution of subjects according to stages of change for exercise and to identify factors that could discriminate subjects in various stages. Methods: The sample consisted of 182 subjects who had metabolic syndrome. The instruments used in this study were the stage placement instrument for exercise, the metabolic syndrome knowledge and metabolic syndrome health belief scale, and the metabolic syndrome exercise self efficacy scale. Data were analyzed using chi-square, ANOVA, and discriminant analysis by using the SPSS 19.0 program. Results: For exercise stages, exercise efficacy, occupation, and exercise benefit showed high standardized canonical discriminant function coefficients. Subjects in precontemplation\/contemplation stage for exercise were more likely to have occupations, had less exercise efficacy and exercise benefit than those in other stage. Conclusion: This study implies that the level of exercise efficacy and exercise benefit of subjects in precontemplation\/contemplation stage need to be enhanced in developing exercise program incorporating the stage of change for metabolic syndrome patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":146241987,"openaccessinfo":{"externalids":{"MAG":"2223319804","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A stochastic model for saturated-unsaturated flow is developed based on the combination of the Karhunen-Loeve expansion of the input random soil properties with a perturbation method. The saturated hydraulic conductivity k_ s (x) is assumed to be log-normal random functions, expressed by f(x). f(x) is decomposed as infinite series in a set of orthogonal normal random variables by the Karhunen-Loeve (KL) expansion and the pressure head is expand as polynomial chaos with the same set of orthogonal random variables. With these expansions, the stochastic saturated-unsaturated flow equation and the corresponding initial and boundary conditions are represented by a series of deterministic partial differential equations which can be solved subsequently by a suitable numerical method. Some examples are given to show the reliability and efficiency of the proposed method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123937700,"openaccessinfo":{"externalids":{"MAG":"2383672848","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proc Amer Assoc Cancer Res, Volume 47, 2006\n\n1264 \n\nInduction of detoxification proteins is an underlying mechanism of drug resistance in cancer chemotherapy. SXR (Steroid and Xenobiotic Receptor) is one of the main xenobiotic sensors whose activation induces transporter and drug-metabolizing enzyme gene transcription. Unlike the vast majority of nuclear receptors, SXR responds to a wide variety of chemically distinct xenobiotics and endobiotics, regulating the expression of genes involved in both inactivation and clearance of these compounds. Preliminary studies have shown that induction of this receptor by Taxol or rifampicin induces overexpression of some genes involved in Irinotecan metabolism and excretion. Irinotecan (CPT-11) is a drug usually employed in metastatic colon cancer which is among the four most common cancers in the world. CPT-11 is frequently submitted to de novo or acquired clinical resistance. Then a better understanding of molecular mechanisms of resistance could lead to an improvement of its therapeutic capacities. We studied here the hypothetical implication of SXR in Irinotecan resistance in LS180, a colorectal cell line. We wondered whether SXR could be an Irinotecan target and whether SXR activated by Irinotecan, could be able to induce its metabolism and excretion genes. First, by immunofluorescence and cellular fractionment, we observed that SXR was translocated in nucleus after 4h-exposure to 500 ng\/ml of CPT-11 or 7.5 ng\/ml of SN-38, its active metabolite. Then, chromatin immunoprecipitation showed in the same conditions that CPT-11 and SN-38 induced SXR recruitment on cytochrome p450 3A4 and p21waf1 promoters. SXR binding to both promoters was followed by mRNA (x10 and x15 with SN-38, respectively) and protein overexpression, detected by quantitative RT-PCR and western blot after 24h stimulation. Thus the nuclear receptor SXR, when activated by CPT-11 or SN-38, induced CYP3A4, partially responsible for CPT-11 inactivation, and p21waf1, a cell cycle regulatory gene. Cell cycle arrest, coupled to detoxification, would allow the cells to repair DNA damages induced by chemotherapy, confirming SXR role in Irinotecan resistance. We currently try to inhibit SXR by siRNA during CPT-11\/SN-38 treatment to observe the impact upon drug cytotoxicity, visualised by the number of cells blocked in S phase (by FACS). Given that SXR can be activated by other cytotoxic drugs, such as Taxol or cisplatin, and that SXR can regulate a broad range of detoxification genes, the nuclear receptor is an ideal molecular target for the manipulation of this detoxification network.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":87046177,"openaccessinfo":{"externalids":{"MAG":"2340213891","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose Common causes of hospitalizations in the United States are acute bacterial skin and skin-structure infections (ABSSSIs). The objectives of this retrospective study were to characterize hospitalized ABSSSI patients including comorbidities and identify the microorganisms associated with the infection. Methods Adults (>18 years) hospitalized with 1 or more primary ABSSSI diagnosis were selected from the Cerner Health Facts electronic medical records database between 2009 and 2013. Causative microorganisms for ABSSSI and Gram-stain type were identified from microbiology culture, including patients with methicillin-resistant Staphylococcus aureus (MRSA). Results Of the 11,705 patients identified, 51.8% were male, with a mean age of 55 years at admission; 49.7% were obese; and 30.9% had diabetes. More than half (56.6%) of patients had no microbiology culture results. Of the patients with an identified ABSSSI-causing pathogen, 63.9% were gram-positive, including 18.4% infected with MRSA; 11.9% were gram-negative; and 24.2% had mixed infections (gram-positive and gram-negative), including 3.6% with MRSA. After adjusting for confounding variables, a significant association was noted between obesity and 30-day ABSSSI-related readmission among males, patients younger than 65 years, and patients without MRSA. Implications Hospitalized ABSSI patients had comorbidities, including obesity, diabetes, hypertension, and depression, which can complicate antibiotic selection. Patient characteristics and pathogen coverage must be considered in antibiotic selection in ABSSSI.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":81184756,"openaccessinfo":{"externalids":{"MAG":"2897057385","ACL":null,"DOI":"10.1097\/IPC.0000000000000688","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: \nIntroduction: Thyroid gland is one of the most important endocrine organs in human body performing multiple functions to maintain homeostasis. Thyroid nodular disease is a frequently encountering problem in surgical OPD that could be malignant or benign. It is more common in females than in males and is expecting that after a decade or so, it will be the 2nd most common malignancy in women. Ultrasound guided fine-needle aspiration (FNA) and core needle biopsy (CNB) are two modalities use to diagnose thyroid swelling preoperatively. Multiple techniques are used to manage thyroid swellings, depending on type and size of thyroid enlargement. Total thyroidectomy, radical and subtotal thyroidectomies are few examples. As thyroid has rich blood supply, ensuring early hemostasis is of vital importance as it directly affects duration of operation as well as visibility of surgical site and intra operative bleeding. Newer techniques include use of harmonic scalpel device that can seal and dissect blood vessels simultaneously by coagulating proteins present in blood vessels, decreasing duration of operation and better hemostasis. \nObjective: This study was done to evaluate the operative duration, post-operative complications and drain output after thyroidectomy with and without use of harmonic scalpel device.\u00a0 \nMaterial and Methods: Randomized controlled trial was conducted at Surgical Unit 3 of Lahore General Hospital between July 2018 and June 2019. Written informed consent was acquired from all of the patients. All participants underwent near total or total thyroidectomy and were euthyroid at the time of surgery.\u00a0 All participants were randomly allocated to one of the two study groups using lottery method. All the data was collected using preformed questionnaire and was evaluated through SPSS v 25. \nInclusion criteria:\u00a0 Age group of 20\u201370 years and American Society of Anesthesiologists (ASA) physical status I\u2013II. \nExclusion criteria: Morbidities (e.g., coagulopathy, diabetes, hypertension, ischemic heart disease). \nResults: Out of 50 patients 35 patients were female with mean age group of 47\u00b14.8 years. 25 participants were enrolled in group in which Harmonic Scalpel device was used while 25 patients underwent conventional method. Mean duration of thyroidectomy from skin incision to skin closure in group with use of harmonic scalpel was 104.19\u00b113.67 minutes while in conventional group it was 128.62 \u00b1 11.76 minutes. Mean output of fluid\/blood in drain post operatively in group treated with harmonic scalpel was 48.82\u00b116.56 while in conventional group, post-operative drain output was 89.45\u00b123.21ml. \nConclusion: Harmonic device is both useful and widely used hemostatic tool in thyroid gland surgery. This device is safe and more compelling than the conventional monopolar diathermy.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":233253122,"openaccessinfo":{"externalids":{"MAG":"3132651617","ACL":null,"DOI":"10.51642\/PPMJ.V30I03.185","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traditional viral marketing problems aim at selecting a subset of seed users for one single product to maximize its awareness in social networks. However, in real scenarios, multiple products can be promoted in social networks at the same time. At the product level, the relationships among these products can be quite intertwined, e.g., competing, complementary and independent. In this paper, we will study the \"interTwined Influence Maximization\" (i.e., TIM) problem for one product that we target on in online social networks, where multiple other competing\/complementary\/independent products are being promoted simultaneously. The TIM problem is very challenging to solve due to (1) few existing models can handle the intertwined diffusion procedure of multiple products concurrently, and (2) optimal seed user selection for the target product may depend on other products' marketing strategies a lot. To address the TIM problem, a unified greedy framework TIER (interTwined Influence EstimatoR) is proposed in this paper. Extensive experiments conducted on four different types of real-world social networks demonstrate that TIER can outperform all the comparison methods with significant advantages in solving the TIM problem.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":18706819,"openaccessinfo":{"externalids":{"MAG":"2462765080","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1607.00542"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One ovarian mucinous cystic tumor that contained a mural solid nodule of anaplastic carcinoma is described in a 35-year-old woman. The epithelial elements consisted of invasive well differentiated mucinous carcinoma. The anaplastic nodule showed some similarities with the cells described in sarcoma and sarcoma-like mural nodules. In favor of a diagnosis of anaplastic carcinoma there are poor circumscription of the nodules, vascular invasion and absence of a prominent inflammatory reaction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45114257,"openaccessinfo":{"externalids":{"MAG":"2339763201","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Heavy metals can seriously endanger human health and the ecological environment due to their toxicity, persistence, and bioaccumulative nature. In this study, an alkali-modified biochar-bentonite composite (CaO-Bent-CB) was prepared by alkali modification of corncob residues and bentonite mixture by calcium chloride and calcination at high temperature under anaerobic conditions. The CaO-Bent-CB composite has a specific surface area of 441.1 m\/g, which is significantly higher than CB (132.7 m\/g) and CaO-CB (177.2 m\/g). Meanwhile, the adsorption perfermance of CaO-Bent-CB to lead ions in water was evaluated. The results showed that the removal efficiency reached 98% after 6 h-adsorption and the adsorption capacity was 109.6 mg\/g when the concentration of lead ion was 120 mg\/L, the weight ratio of bentonite to corncob residues was 1:5, and the dosage was 1 g\/L. The adsorption capacity of CaO-Bent-CB was higher than that of CB (13.4 mg\/g), bentonite (72.9 mg\/g) and CaO-CB (86.9 mg\/g). Moreover, the lead ion contaminated soil was stabilized by CaO-Bent-CB. When the concentration of lead ion in soil is 2200 mg\/kg, and the loading of CaO-Bent-CB is 8% of soil, the concentration of lead ions in acid leachate (H2SO4-HNO3, pH=3.2, \u7b2c*\u671f CaO-Bentonite-CB \u5bf9 Pb\u5438\u9644\u6027\u80fd\u7684\u7814\u7a76 2 12 h-soaking) was 4.5 mg\/L, which is lower than the standard value of hazardous waste identification (5 mg\/L). The results show that CaO-Bent-CB has a great potential in the treatment of water and soil with heavy metals.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":234168833,"openaccessinfo":{"externalids":{"MAG":"3137536264","ACL":null,"DOI":"10.15541\/JIM20200745","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It has been suggested that green tea-derived epigallocatechin gallate (EGCG), which has antimicrobial properties, might help prevent dental caries. However, the detailed properties of EGCG remain unclear. In this study, the antimicrobial properties of EGCG were evaluated by examining its bactericidal activity, its inhibitory effects against bacterial growth, acid production, acidic end-product formation, and sugar uptake (phosphoenolpyruvate-dependent phosphotransferase system, PEP-PTS activity), and its effects on bacterial aggregation, using monocultured planktonic cells of Streptococcus mutans and non-mutans streptococci. Coincubating S. mutans with EGCG (1 mg\/mL) for 4 h had no bactericidal effects, while it decreased the growth and acid production of S. mutans by inhibiting the activity of the PEP-PTS. EGCG (2 mg\/mL) caused rapid bacterial cell aggregation and had reduced the optical density of S. mutans cell suspension by 86.7% at pH 7.0 and 90.7% at pH 5.5 after 2 h. EGCG also reduced the acid production of non-mutans streptococci, including S. sanguinis, S. gordonii, and S. salivarius, and promoted the aggregation of these non-mutans streptococci. Furthermore, these antimicrobial effects of short-term EGCG treatment persisted in the presence of saliva. These results suggest that EGCG might have short-term antibacterial effects on caries-associated streptococci in the oral cavity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234792671,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1159\/000515814","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.karger.com\/Article\/Pdf\/515814","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Chitin is the second most common polysaccharide found in nature. It is present in crustacean shells, insect exoskeletons, parasitic nematode eggs and gut linings, and in the cell wall of fungi. The deacetylated derivative of chitin, chitosan, is less common but is particularly evident in certain species of fungi, such as Cryptococcus, and the cyst wall of Entamoeba. How mammals sense and respond to these polymers is not well understood, and conflicting reports on their immunological activity have led to some controversy. Despite this, promising translational applications that exploit the unique properties of chitin and chitosan are being developed.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":3}},"corpusid":9121405,"openaccessinfo":{"externalids":{"MAG":"2004659460","ACL":null,"DOI":"10.1371\/journal.ppat.1003080","PubMedCentral":"3542151","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plospathogens\/article\/file?id=10.1371\/journal.ppat.1003080&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The number of high and very high resolution (VHR) optical satellite sensors, as well as the number of medium resolution satellites is continuously growing. However, not all high-resolution optical satellite imaging cameras have a sufficient and stable calibration in time. Due to their high agility in rotation, a quick change in viewing direction can lead to satellite attitude oscillation, causing image distortions and thus affecting image geometry and geo-positioning accuracy. This paper presents an approach based on re-projection of regularly distributed 3D ground points from object in image space, to detect and estimate the periodic distortions of Pl\u00e9iades tri-stereo imagery caused by satellite attitude oscillations. For this, a hilly region was selected as a test site. Consequently, we describe a complete processing pipeline for computing the systematic height errors (deformations, waves) of the satellite-based digital elevation model by using a Lidar high resolution terrain model. Ground points with fixed positions, but with two elevations (actual and corrected) are then re-projected to the satellite images with the aid of the Rational Polynomial Coefficients (RPCs) provided with the imagery. Therefore, image corrections (displacements) are determined by computing the differences between the distinct positions of corresponding points in image space. Our experimental results in Allentsteig (Lower Austria) show that the systematic height errors of satellite-based elevation models cannot be compensated with an usual or even high number of Ground Control Points (GCPs) for RPC bias correction, due to insufficiently known image orientations. In comparison to a reference Lidar Digital Terrain Model (DTM), the computed elevation models show undulation effects with a maximum height difference of 0.88 m in along-track direction. With the proposed method, image distortions in-track direction with amplitudes of less than 0.15 pixels were detected. After applying the periodic distortion compensation to all three images, the systematic elevation discrepancies from the derived elevation models were successfully removed and the overall accuracy in open areas improved by 33% in the RMSE. Additionally, we show that a coarser resolution reference elevation model (AW3D30) is not feasible for improving the geometry of the Pl\u00e9iades tri-stereo satellite imagery.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":248728728,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/rs14102303","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-4292\/14\/10\/2303\/pdf?version=1653292204","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Cellulose acetate artefacts in museum collections cover a period from the early 1900's to the present day. Conservators have observed that certain of these objects are showing signs of warping, crazing, cracking, discolouration and shrinkage accompanied by a strong smell of acetic acid. Previous studies on cellulose nitrate artefacts show a correlation existed between the residual sulfate from manufacture and subsequent susceptibility to degradation. A parallel study of the accelerated ageing of modern samples of cellulose acetate and also selected artefacts dating from the 1940's has been carried out. The tests involved exposure of the objects to temperatures of 35 \u00b0C, 50 \u00b0C and 70 \u00b0C and relative humidities of 12 %, 55 % and 75 % for extended periods of time. The samples were monitored for changes both in their visual appearance, mass and chemical composition. Chemical analysis was carried out using micro FT-IR spectrometry and ion chromatography. The changes in the molar mass distribution were studied using gel permeation chromatography. Naturally aged samples have also been studied to help validate the accelerated ageing studies.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":99584042,"openaccessinfo":{"externalids":{"MAG":"2492575572","ACL":null,"DOI":"10.1021\/BK-2001-0779.CH012","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Autonomous navigation of a mobile robot involves self-steering of a robot from one place to another based on computational resources on-board the robot. There are many different ways to approach mobile robot navigation, with path planning and obstacle avoidance playing a key role. This paper discusses three methods used in obstacle avoidance and path planning i.e., the Bug algorithms, the Potential Field methods and the Vector Field Histogram method which are all active sensor-based methods. A more robust system for use to achieve autonomous navigation in any environment can be developed by fusing technologies or schemes by taking advantage of the merits of the different systems while limiting their drawbacks.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":55968059,"openaccessinfo":{"externalids":{"MAG":"1931898074","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We investigated dry matter (DM) and fruit production of tomato plants, the effects of CO2 levels on DM production, and light-use efficiency (LUE) in a tomato production system based on short-term, low-truss crop management during six consecutive periods over one year in a commercial greenhouse. The CO2 concentration, total dry matter production (TDM), and LUE differed significantly among the periods. Since LUE was significantly correlated with the mean daytime CO2 concentration, we modeled LUE empirically from that. We developed a model to predict LUE and DM production of tomato plants and validated the model using data from the six periods. We accurately predicted LUE and TDM within a range of ca. 400 to 650 \u03bcmol\u00b7mol\u22121 daytime CO2 concentration. However, when daytime CO2 concentration was beyond this range, or when a management failure such as inadequate irrigation occurred, predicted values differed significantly from observed values.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219505546,"openaccessinfo":{"externalids":{"MAG":"3027075373","ACL":null,"DOI":"10.2503\/hortj.utd-143","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/hortj\/89\/4\/89_UTD-143\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Field experiments were conducted in Seville (SW Spain) on a sandy loam soil (Typic Xerofluvent) to investigate the usefulness of CWSI in screening cotton genotypes for drought resistance and yield characteristics. Non-water-stressed baseline equations were determined in 1993 and 1994 by conducting a diurnal study of a well watered crop. Seventeen upland cotton genotypes were evaluated in 1994 in randomized complete blocks with four replications. Eight furrow irrigations were applied from June 8 to August 23 with a total of 800-900 mm of H2O applied. Crop Water Stress Index (CWSI) was quantified in seven dates. Variance analysis showed that dates and genotypes were highly significant for seasonal CWSI ranging from 0.38 for Acala Germain 510 to 0.59 for La Ni\u00f1a. Seed cotton yield was negative correlated to mean seasonal CWSI (r = -0.28). Seed cotton yields ranged from 4658 kg ha-1 for Stoneville 324 to 5723 for La Chata (a Spanish cultivar). CWSI revealed a good water status for some cultivars with low values in this characteristic but it was not a determining factor in the performance of cultivars under well-watered conditions. CWSI corroborates the drought tolerance of some Spanish genotypes such as Maria del Mar and could be a good tool in evaluating genotypic drought tolerance if a low seasonal CWSI is combined with high yields under well watered conditions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":232250774,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Machine learning (ML) is believed to be an effective and efficient tool to build reliable prediction model or extract useful structure from an avalanche of data. However, ML is also criticized by its difficulty in interpretation and complicated parameter tuning. In contrast, visualization is able to well organize and visually encode the entangled information in data and guild audiences to simpler perceptual inferences and analytic thinking. But large scale and high dimensional data will usually lead to the failure of many visualization methods. In this paper, we close a loop between ML and visualization via interaction between ML algorithm and users, so machine intelligence and human intelligence can cooperate and improve each other in a mutually rewarding way. In particular, we propose \"transparent boosting tree (TBT)\", which visualizes both the model structure and prediction statistics of each step in the learning process of gradient boosting tree to user, and involves user's feedback operations to trees into the learning process. In TBT, ML is in charge of updating weights in learning model and filtering information shown to user from the big data, while visualization is in charge of providing a visual understanding of ML model to facilitate user exploration. It combines the advantages of both ML in big data statistics and human in decision making based on domain knowledge. We develop a user friendly interface for this novel learning method, and apply it to two datasets collected from real applications. Our study shows that making ML transparent by using interactive visualization can significantly improve the exploration of ML algorithms, give rise to novel insights of ML models, and integrates both machine and human intelligence.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":16715559,"openaccessinfo":{"externalids":{"MAG":"2532108707","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1610.05463"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Enhanced prostaglandin production is postulated to contribute to altered vascular reactivity and glomerular hyperfiltration in early insulin-deficient diabetes mellitus. Rats with streptozocin-induced diabetes (STZ-D) show glomerular hyperfiltration and develop renal disease. BB rats with genetic diabetes (BB-D) also hyperfilter but have only minor renal lesions. We therefore compared glomerular and mesangial prostaglandin E2 (PGE2) production and glomerular contractility in response to pressors as a reflection of in vitro vascular reactivity in these models. Glomeruli isolated from rats with 3 wk of STZ-D produced significantly more PGE2 under basal and ionophore A23187-stimulated conditions than those from control rats. Glomeruli from BB-D rats under basal and stimulated conditions, however, generated amounts of PGE2 that were comparable to either those of nondiabetic litter mates or of normal Wistar rats. Mesangial cells cultured from glomeruli of STZ-D, BB-D, and control rats all had identical prostaglandin profiles judged by conversion of [14C]arachidonic acid. They also produced comparable amounts of PGE2 under basal conditions and after stimulation with angiotensin II or A23187, as determined by radioimmunoassay. Planar surface area of glomeruli isolated from control rats showed a dose-dependent decrease in response to angiotensin II (10\u221211-10\u22129 M). This response to angiotensin II was at least as great in glomeruli from STZ-D rats. Contraction of glomeruli from control and STZ-D rats was also comparable after vasopressin or norepinephrine. Similarly, glomeruli from BB-D and BB control rats contracted in a comparable fashion to angiotensin II and norepinephrine. We conclude that in vitro PGE2 production is enhanced in glomeruli from STZ-D rats but not in those from BB-D rats, as compared with their respective controls. Because the contractile response of isolated glomeruli to pressors was comparable in all groups, our in vitro results argue against a major role of prostaglandins in the hyperfiltration of diabetes mellitus.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":22685718,"openaccessinfo":{"externalids":{"MAG":"1973835428","ACL":null,"DOI":"10.2337\/diab.36.12.1468","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo develop and validate rates of potentially preventable emergency department (ED) visits as indicators of community health.\n\n\nDATA SOURCES\nAgency for Healthcare Research and Quality, Healthcare Cost and Utilization Project 2008-2010 State Inpatient Databases and State Emergency Department Databases.\n\n\nSTUDY DESIGN\nEmpirical analyses and structured panel reviews.\n\n\nMETHODS\nPanels of 14-17 clinicians and end users evaluated a set of ED Prevention Quality Indicators (PQIs) using a Modified Delphi process. Empirical analyses included assessing variation in ED PQI rates across counties and sensitivity of those rates to county-level poverty, uninsurance, and density of primary care physicians (PCPs).\n\n\nPRINCIPAL FINDINGS\nED PQI rates varied widely across U.S. communities. Indicator rates were significantly associated with county-level poverty, median income, Medicaid insurance, and levels of uninsurance. A few indicators were significantly associated with PCP density, with higher rates in areas with greater density. A clinical and an end-user panel separately rated the indicators as having strong face validity for most uses evaluated.\n\n\nCONCLUSIONS\nThe ED PQIs have undergone initial validation as indicators of community health with potential for use in public reporting, population health improvement, and research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3668615,"openaccessinfo":{"externalids":{"MAG":"2600405460","ACL":null,"DOI":"10.1111\/1475-6773.12687","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc5583364?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The review acknowledges that research on the family and its contribution to achievement in ethnic minority children is important. Past research and theorizing suggest the need for new directions, however. For example, research in educational achievement predicts educational failure for African-American students and educational success for Asian-American students. Little differentiation is made either among African-Americans or among Asian-Americans of different cultural, language, immigration, and economic backgrounds. The theory and design of research on family and educational achievement have been influenced by prevailing societal stereotypes. Research and policy implications of this review include the need to move toward cultural\/ecological theories of achievement socialization and development.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31960545,"openaccessinfo":{"externalids":{"MAG":"1970549132","ACL":null,"DOI":"10.1111\/J.1467-8624.1990.TB02783.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We propose a novel excimer-laser crystallization method that uses a phase-shift mask for large-grain growth of Si thin films on the glassy substrate. Due to interference effects of the laser light, the phase difference of light at the mask results in spatial modulation of light intensity at the sample surface, which triggers the lateral grain growth. Grains as large as 7 \u00b5m could be grown by a single-shot irradiation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250811845,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1143\/JJAP.37.L492","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Infrared ellipsometry is a valuable tool to investigate the average stress and the stress distribution in thin silicon carbide layers grown on silicon as well as to monitor the changes in the stress state during device processing. It was obtained that low temperature carbonization in combination with low temperature epitaxial growth led to a compressive stress component in the SiC\u2013Si interface region, whereas the average stress state is tensile. Ge incorporation in the interface lowered the tensile residual stress component. Metallization of SiC increases the tensile stress in the SiC on Si. (\u00a9 2008 WILEY\u2010VCH Verlag GmbH & Co. KGaA, Weinheim)","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":119899979,"openaccessinfo":{"externalids":{"MAG":"2006065875","ACL":null,"DOI":"10.1002\/pssa.200777785","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An analog of the Trotter formula for the Arratia flow is presented. Perturbations of the Brownian web by mappings associated with an ordinary differential equation with a smooth right part are considered and proved to be convergent exclusively in the weak sense. The flow obtained as a limit is the Arratia flow with drift.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55151304,"openaccessinfo":{"externalids":{"MAG":"3098039251","ACL":null,"DOI":"10.31390\/COSA.12.1.07","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This essay discusses an approach to teaching religious studies in a general education or core curricu- lum that I have experimented with for the last decade, which I call the \"Learning Covenant.\" The Learning Covenant brings together various pedagogical theories, including transformational, experiential, contract, and cooperative learning, in an attempt to address diverse learning styles, multiple intelligences, and student learn- ing assessment. It has advantages over more traditional teacher-directed approaches to teaching, including meeting student resistance to \"required\" courses head-on by inviting them to identify learning needs regardless of chosen vocation and meeting them in the context of a religious studies course, recognizing the multiple ways in which students learn and providing a variety of opportunities for students to express their learning, and allowing students opportunity to take increased responsibility for their own learning. The essay will focus on the Learning Covenant's develop- ment, components, strengths, and drawbacks.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":2053226,"openaccessinfo":{"externalids":{"MAG":"2158649891","ACL":null,"DOI":"10.1111\/J.1467-9647.2007.00394.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This is supported by evidence that cyclooxygenase 2 inhibitor is given safely to patients with AIU. The present study was designed to investigate the role of genetic polymorphism of LT related genes in the pathogenesis of AIU via a case-control study. We screened single nucleotide polymorphisms (SNPs) in genes encoding enzymes involved in leukotriene synthesis in the Korean population with AIU (n=101), ASA-intolerant asthma (AIA, n=95) and normal healthy controls (n=123). Genotype was determined by primer extension reactions using the SNapShot ddNTP primer extension kit. Among 8 SNPs of four LT related genes, the polymorphism of ALOX5 at positions of -1708 G>A showed significant difference in genotype frequency between AIU and AIA (p=0.01). Furthermore, there were significant differences observed in the frequencies of two ALOX5 haplotypes between the AIU group and AIA group (p<0.05). However, there were no differences in allele, genotype, or haplotype frequencies of ALOX5 between the AIU group and the normal control group. These results suggested that ALOX5 has a differing contribution in two major clinical pathogenesis related to ASA-sensitivity.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":2871053,"openaccessinfo":{"externalids":{"MAG":"2153903025","ACL":null,"DOI":"10.3346\/jkms.2005.20.6.926","PubMedCentral":"2779320","ArXiv":null},"license":"CCBYNC","url":"https:\/\/europepmc.org\/articles\/pmc2779320?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The impact of problem formulation modifications on predictive controller tuning is investigated. First, the proposed tuning method is shown to adapt to disturbance characteristic changes and thus, takes full economic advantage of the scenario. The second topic concerns point-wise-in-time constraints and the impact of constraint infeasibility. Specifically, we shift the tuning question from selection of nonintuitive weighting matrix parameters to that of a few key parameters and results in a rather intuitive trade-off between expected profit and expected constraint violations. Finally, we show that simple modifications will allow for the consideration of various feedback structures, including computational delay and partial state information. The overall conclusions of the work are that the results of the automated algorithm will help build an intuitive understating of the dynamics of the process and ultimately result in a higher level trade-off between profit and constraint observance. \u00a9 2014 American Institute of Chemical Engineers AIChE J, 60: 3473\u20133489, 2014","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":121226279,"openaccessinfo":{"externalids":{"MAG":"2062465035","ACL":null,"DOI":"10.1002\/AIC.14529","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Eckart frame is a unique embedding in the theory of molecular vibrations and rotations. It is defined by the condition that the Coriolis coupling of the reference structure of the molecule is zero for every choice of the shape coordinates. It is far from trivial to set up Eckart kinetic energy operators (KEOs), when the shape of the molecule is described by curvilinear coordinates. In order to obtain the KEO, one needs to set up the corresponding contravariant metric tensor. Here, I derive explicitly the Eckart frame rotational measuring vectors. Their inner products with themselves give the rotational elements, and their inner products with the vibrational measuring vectors (which, in the absence of constraints, are the mass-weighted gradients of the shape coordinates) give the Coriolis elements of the contravariant metric tensor. The vibrational elements are given as the inner products of the vibrational measuring vectors with themselves, and these elements do not depend on the choice of the body-frame. The present approach has the advantage that it does not depend on any particular choice of the shape coordinates, but it can be used in conjunction with all shape coordinates. Furthermore, it does not involve evaluation of covariant metric tensors, chain rules of derivation, or numerical differentiation, and it can be easily modified if there are constraints on the shape of the molecule. Both the planar and non-planar reference structures are accounted for. The present method is particular suitable for numerical work. Its computational implementation is outlined in an example, where I discuss how to evaluate vibration-rotation energies and eigenfunctions of a general N-atomic molecule, the shape of which is described by a set of local polyspherical coordinates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24749162,"openaccessinfo":{"externalids":{"MAG":"2062663545","ACL":null,"DOI":"10.1063\/1.4865750","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/pubs.aip.org\/aip\/jcp\/article-pdf\/doi\/10.1063\/1.4865750\/13057489\/074101_1_online.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract : Two different approaches to high performance systems for Artificial Intelligence (AI) applications have been set forth at Berkeley: one by the SPUR (Symbolic Processing Upon RISC) group, the other by the Aquarius group. In particular, the SPUR group proposed multiple, homogeneous, RISCs (Reduced Instruction Set Computers) with a functional programming (LISP) paradigm while the Aquarius group proposes multiple, heterogeneous, specialized processors with a logic-programming (Prolog) paradigm. The two groups agreed to meet for the purpose of studying the relative merits of their two approaches and to report on their findings. Meetings were held in October and November of 1984. The meetings consisted of descriptions of the two projects and discussions of the various alternatives available. This report delineates the results of those meetings; in particular, the dissimilar objectives of the two projects are stated and a point by point discussion of the major issues are provided. The two projects are now more similar in certain aspects in which they differed a year ago. The authors describe the two projects as the are now.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":58776864,"openaccessinfo":{"externalids":{"MAG":"1884114744","ACL":null,"DOI":"10.21236\/ada169224","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This work explores the synthesis and properties alteration of new composite membrane system based on polyvinyl chloride (PVC) grafting with polyacrylic acid (PAA) using argon (Ar) plasma. The membranes of PVC were synthesized by solution-casting method, where PAA was deposited onto PVC using dielectric barrier discharge (DBD) at atmospheric pressure with different carrier gases such as (O2, Ar, N2, air) to get the optimum condition for grafting process of acrylic acid. Physicochemical properties were investigated as function of varied carrier gas for grafting process of PAA. ATR-FTIR has provided information on details of chemical structure of membrane, while morphological changes are characterized by scanning electron microscope (SEM). Moreover, mechanical properties of the membranes were studied using tensile strength (TS). Surprising, the wettability behavior of modified PVC membrane with AA vapor (plasma polymerization) is closed to such membranes those treated with O2 plasma-AA liquid. An ultra-thin, pin hole free films of PAA were deposited onto PVC membranes leading to the increase of the wettability feature of the membranes. Meanwhile, ion exchange capacity (IEC) of such membranes was investigated by volumetric method and it is directly dependent on the electrochemical properties of membranes. The IEC values in case of grafting with PAA in vapor phase are promising and maybe related to the special structure of plasma deposited polymers. The grows in the electronegativity of the grafted and sulfonated membranes is an indication to the proton permeability. Therefore, such membranes may be used as polyelectrolyte membranes (PEM) in direct methanol fuel cell (DMFC).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":210952401,"openaccessinfo":{"externalids":{"MAG":"2999243689","ACL":null,"DOI":"10.21608\/absb.2019.67895","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/absb.journals.ekb.eg\/article_67895_243fed1f01946c796ca9cc28a2539565.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0Earth's and Planetary Interiors: Observation and Numerical Models of Paleomagnetic and Planetary Magnetism; Beijing, China, 7\u201311 July 2010; The second international Beijing Earth and Planetary Interior Symposium (BEPIS;http:\/\/www.paleomag.net\/meeting) was held at the Institute of Geology and Geophysics, Chinese Academy of Sciences (CAS), just down the road from the Bird's Nest and other iconic structures of the 2008 Beijing Olympics. The symposium was organized by Rixiang Zhu (CAS, Beijing, China) and Keke Zhang (Exeter University, Exeter, UK) and brought together more than 100 scientists, including 30 graduate students from 10 countries. Thirty-nine invited talks were organized along three major themes: planetary dynamos, paleomagnetism, and mineral magnetism. The talks were held in alternating and sometimes closely interleaved sessions and were supported by 40 poster presentations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":119781438,"openaccessinfo":{"externalids":{"MAG":"1974723789","ACL":null,"DOI":"10.1029\/2011EO190005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Compressed Baryonic Matter (CBM) Experiment is planned to be installed at a future accelerator facility, SIS 100\/300 of FAIR (Facility for Antiproton and Ion Research), GSI (Gesellschaft f\u00fcr SchwerIonenforschung) to study nuclear matter under extreme conditions with a high baryon density. A Ring Imaging Cherenkov (RICH) detector is now being developed for electron identification at pe < 8 GeV\/c, well separated from pions. In order to optimize the physics performance of the CBM-RICH detector and to investigate different gas radiators, we developed a mini-RICH detector with a gas system as a first prototype and tested it with the pe \u2243 60 MeV\/c electron beam at the Pohang Accelerator Laboratory (PAL).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256327878,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3938\/jkps.61.1223","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT \n Varroa mites, Varroa destructor Anderson & Trueman, are economically important pests of honey bees. Varroa mites are principally controlled within honey bee colonies using miticides. However, despite their importance in managing mite populations for apiculture, potential effects of miticides on honey bees are poorly understood. Using gas chromatography-flame ionization detection, we investigated concentrations, over variable time frames and within different body regions, of two commonly used miticides, tau-fluvalinate and amitraz, after dermal exposure to honey bees. We also quantified mortality of honey bees exposed to each miticide at both a low and high dose. Significant differences were observed in distributions of miticides among body regions. Within honey bee body parts, tau-fluvalinate was more readily absorbed and decreased in concentration more rapidly than amitraz. Mortality increased with higher dosages of miticides, and at higher dosages mortality was greater from fluvalinate than from amitraz. For individual honeybees, our results for rate of breakdown suggest that fluvalinate may be the preferred miticide for apiculturists, whereas our mortality results suggest that amitraz may be preferable. Either choice must be weighed against geographic variation in varroa resistance to each pesticide and attendant costs of parasitism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31137548,"openaccessinfo":{"externalids":{"MAG":"2156605892","ACL":null,"DOI":"10.1603\/EC12300","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Memory consolidation requires the encoding of neocortical memory traces, which is thought to occur during hippocampal oscillations called sharp-wave ripples (SWR). Evidence suggests that the hippocampus communicates memory-related neural patterns across distributed cortical circuits via its major output pathways. Here, we sought to understand how this information is processed in the retrosplenial cortex (RSC), a primary target circuit. Using patch-clamp recordings from mice during quiet wakefulness, we found that SWR-aligned synaptic modulation is widespread but weak, and that spiking responses are sparse. However, using cell type and projection-specific two-photon calcium imaging and optogenetics, we show that, starting 1-2 seconds before SWR, superficial inhibition in RSC is reduced, along with thalamocortical input. We propose that pyramidal dendrites experience a period of decreased local inhibition and subcortical interference in a seconds-long time window preceding hippocampal SWR. This may aid communication of weak and sparse SWR-aligned excitation between the hippocampus and neocortex, and promote the selective strengthening of memory-related connections.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":234350348,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2021.05.05.442741","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1101\/2021.05.05.442741","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Comparisons between animal and human communication are invaluable for \nunderstanding the evolution of language and, as our closest living relatives, \nchimpanzees can provide particularly important insights into this. Here I examined \nunimodal (UM) and multimodal (MM) communication in wild chimpanzees, in an \nintegrated manner. I found that although MM signals were produced infrequently, and \nat lower rates compared to captivity, the vast majority of adult and sub-adult \nindividuals did freely combine vocal, gestural and facial signals to produce MM signals. \nA total of 48 free MM signal combinations were observed, incorporating a wide range \nof different signal types from different modalities. Focusing on one specific vocalgestural \nMM signal, I found that MM combinations and UM gestural signals were more \nsuccessful in eliciting responses compared to UM vocal signals. \nTo investigate signal function more systematically I focused on one common grooming \ngesture, the big loud scratch (BLS), and tested several competing functional \nhypotheses. I found little evidence to support the hypotheses that this signal operates \nas an attention-getter, or as a referential signal. In contrast, my data suggested that in \nthis community of chimpanzees, the BLS facilitates the negotiation of roles within a \ngrooming bout. Groomers used BLSs to request grooming during grooming bouts and \nthe BLS seemed to show willingness to groom, both to initiate a grooming bout, and \npotentially during a bout when groomees intend to start grooming their partner. \nFinally, to explore the theoretical link between the evolution of communication and \ncooperation I tested whether, on an individual level, there was a positive relationship \nbetween communicativeness and cooperativeness in chimpanzees. In contrast to \ntheoretical predictions, I found a significantly negative relationship between these two \ndomains, indicating that more communicative chimpanzees were less cooperative. I \nexplore several potential explanations for this highly unexpected finding.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":148601033,"openaccessinfo":{"externalids":{"MAG":"2618967376","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article seeks to revisit the French social space 30 years after Pierre Bourdieu first mapped it in Distinction. Using data from the International Social Survey Programme, it deploys geometric data analysis to construct a model of the space of class positions that is remarkably similar in its structure to that presented by Bourdieu despite three decades of economic transformation. The relationship with occupational groups and geographical space is also familiar, though gender and, to a greater extent, age are perhaps more prominent than when Bourdieu was writing. The article then goes on to demonstrate the multidimensional nature of symbolic violence, in the form of perception of one's place, and the manner in which social reproduction is misrecognised. On the latter point, it transpires that while there is recognition of unfair advantage, not only is faith in meritocracy the prevailing view but the dominated are the most likely to deny that having educated parents makes a difference to whether one 'gets ahead' or not.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":236356419,"openaccessinfo":{"externalids":{"MAG":"3165136243","ACL":null,"DOI":"10.1177\/00380261211020182","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1177\/00380261211020182","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Background: Intraoral scanners (IOSs) in implantology represent a viable approach for single teeth or partial arches. However, when used for complete edentulous arches or long-span edentulous areas, it has been demonstrated that there is a need for improvement of IOS-related techniques. Therefore, the aim of this in vitro study was to assess the trueness and precision of a complete arch digital impression on four and six implants taken with or without a customized, prosthetic-based impression template. Materials and Methods: Two experimental models were prepared, representative of a complete edentulous mandible restored with four and six implants with built-in scan abutments. Models were scanned with (test group, TG) or without (control group, CG) the prosthetic-based impression template. Eight scans were taken for each model. The time needed to take impressions, error, trueness, and precision were evaluated. A statistical analysis was performed. Results: In the case of four implants, the time needed for the impression was 128.7 \u00b1 55.3 s in the TG and 81.0 \u00b1 23.5 s in the CG (p = 0.0416). With six scan abutments, the time was 197.5 \u00b1 26.8 and 110.6 \u00b1 25.2 s in the TG and CG, respectively (p = 0.0000). In the TG, no errors were experienced, while in the CG, 13 impressions were retaken due to incorrect stitching processes. In the four-implant impression, the mean angle deviation was 0.252 \u00b1 0.068\u00b0 (95% CI 0.021\u20130.115\u00b0) in the CG and 0.134 \u00b1 0.053\u00b0 (95% CI 0.016\u20130.090\u00b0) in the TG. The difference was statistically significant (p = 0.002). In the six-implant impression, the mean angle deviation was 0.373 \u00b1 0.117\u00b0 (95% CI 0.036\u20130.198\u00b0) in the CG and 0.100 \u00b1 0.029\u00b0 (95% CI 0.009\u20130.049\u00b0) in the TG (p = 0.000). In the TG, there were no statistically significant differences in the mean angle deviation within the group (p > 0.05), but there were in the CG. A colorimetric analysis showed higher deviations from the original model for the six-implant impression without a prosthetic template. Conclusions: Although all of the impressions exhibited deviation from the original model in the range of clinical acceptability, the prosthetic-based impression template significantly improved the trueness and precision of complete edentulous arches rehabilitated with four or six implants, making the complete arch digital impression more predictable.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":221763119,"openaccessinfo":{"externalids":{"MAG":"3048830862","ACL":null,"DOI":"10.3390\/ma13163543","PubMedCentral":"7475836","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1944\/13\/16\/3543\/pdf?version=1603442172","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Fuzzy and anti fuzzy normal subgroups are the current instrument for dealing with ambiguity in various decision-making challenges. This article discusses \n \n \u03b3\n \n -anti fuzzy normal subgroups and \n \n \u03b3\n \n -fuzzy normal subgroups. Set-theoretic properties of union and intersection are examined and it is observed that union and intersection of \n \n \u03b3\n \n -anti fuzzy normal subgroups are \n \n \u03b3\n \n -anti fuzzy normal subgroups. Employee selection impacts the input quality of employees and hence plays an important part in human resource management. The cost of a group is established in proportion to the fuzzy multisets of a fuzzy multigroup. It was a good idea to introduce anti-intuitionistic fuzzy sets and anti-intuitionistic fuzzy subgroups, as well as to demonstrate some of their algebraic features. Product of \n \n \u03b3\n \n -anti fuzzy normal subgroups and \n \n \u03b3\n \n -fuzzy normal subgroups is defined, the product's algebraic nature is analyzed, and the findings are supported by presenting \n \n \u03b3\n \n -anti typical sections with blurring and \n \n \u03b3\n \n -ordinary parts with the weirdness of well-defined and well-established groups of genetic codes.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":250633281,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2022\/1252885","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/ddns\/2022\/1252885.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A meta-analysis was performed on the response times (RTs) of Alzheimer patients and normal subjects for 61 experimental conditions. Regression of the RTs of Alzheimer patients against those of young normals yielded a linear function: Alzheimer (time) = A+B Young (time), where B was a constant proportion of 2.3. As dementia severity increased, so too did the magnitude of this RT slowing, B rising from 2.0 to 2.9. The linearity of this function suggests that Alzheimer's disease produces a generalized slowing of cognitive processing. Since Alzheimer patients are proportionally slower than normals, the size of the absolute difference in RT between Alzheimer patients and normals increases as task complexity rises, irrespective of the exact cognitive operations being tested. It will be necessary to take this generalized slowing into account when interpreting differences in the effect that various experimental conditions have on the RTs of normals and Alzheimer patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39802443,"openaccessinfo":{"externalids":{"MAG":"2045427558","ACL":null,"DOI":"10.1080\/01688639208402831","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In today's society there is tougher climate both financially and time wise. Accountants working under tight deadlines leading to the compromise between quality and quantity in the audit process and them therefor are being guilty of so-called reduced audit quality, RAQ. Reduced audit quality involves intentional actions designed to somehow reduce the evidence contained in the audit. We examine in this study the impact of time budget pressure (TBP), underreporting of time (URT), ethical organizational culture and charismatic leadership has on the frequency of RAQ.Previous research has already shown that there are clear links between TBP and RAQ, between URT and RAQ and between ethical culture in organizations and audit quality available. Five hypotheses were designed to the study. Four of these deal with the factors mentioned above, the fifth addresses the charismatic leadership's impact on RAQ.Of the hypotheses established in the study two were certainly accepted, it was the link between RAQ and TBP and the link between URT and TBP. We found even partial acceptance of the ethical organizational culture related to RAQ however, the hypothesis could not be fully accepted.A survey was conducted among certified public accountants in Sweden. The survey resulted in 185 respondents. The analysis of this study showed that there are clear links between time budget pressure and reduced audit quality. The ethical culture of the organization showed some links with RAQ, but not as whole but on a more specific plan for different parts of the ethical culture. We did not find any evidence that charismatic leadership would affect audit quality in any direction.Keywords: RAQ, time budget pressure, charismati","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":153170694,"openaccessinfo":{"externalids":{"MAG":"592279643","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The mechanism of increased nocturnal urine production in adult patients complaining of nocturia has seldom been reported. The objective of this clinical study is to investigate the circadian rhythm of both urine production and plasma arginine-vasopressin (AVP) level, and the efficacy of intranasal instillation of 1-deamino-8-D-arginine-vasopressin (DDAVP) in adult patients complaining of nocturia. Eight patients (seven men, one woman) who ranged in age from 44 to 77 years (mean 64.1 years) were examined. Three of them suffered from Shy-Drager syndrome, and no patient had shown any improvement of symptoms in spite of administration of anti-cholinergic agents and restriction of water intake. Nocturnal urine volume was more than bladder capacity in all patients, and no patient showed normal elevation of nocturnal plasma AVP level. Intranasal administration of DDAVP of 5 or 10 micrograms revealed marked decrease in nocturia, and nocturnal urine volume (p < 0.01). There were mild side effects (headache, nasal obstruction, and hyponatremia) not requiring any treatment. In conclusion, DDAVP is a safe and effective treatment for adult patients complaining of nocturia due to hyperproduction of nocturnal urine and inappropriate nocturnal secretion of AVP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13300541,"openaccessinfo":{"externalids":{"MAG":"25919116","ACL":null,"DOI":"10.5980\/JPNJUROL1989.84.2131","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"AGBIR.2023; 39(2): 467-469. Introduction: Small-scale irrigation has direct and indirect impacts in enhancing the livelihood of farm households through diversification of crops grown, increased agricultural production, increased household income, and increased employment opportunities. Objective: This study was conducted to identify determinant factors of household's participation in irrigation in the Emba Alaje district. Methodology: In this study, multi-stage sampling technique was used to select 137 target respondents. The primary data were collected using an interview schedule and conducting focus group discussions and key informant interview. Various documents were reviewed to collect the secondary data. Result: The probit model result indicates that participation in small-scale irrigation is positively and significantly influenced by livestock holding, total cultivated land size, and frequency of extension contact. Whereas, participation in small-scale irrigation is negatively influenced by age of the household head, distance to irrigation water and distance to farmer training center, participation in small-scale irrigation. Conclusion: In the study area the participation in small-scale irrigation was significantly affected by different socio-economic, demographic and institutional factors. Recommendation: To solve the problems and improve small-scale irrigation participation, the government, especially irrigation development office of the district should create awareness to farmers about utilization of irrigation scheme.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":260309374,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The purpose of this study was to evaluate the effect of traffic volume on ambient black carbon (BC) concentration in an inner-city neighborhood \"hot spot\" while accounting for modifying effects of weather and time. Continuous monitoring was conducted for 12 months at the Baltimore Traffic Study site surrounded by major urban streets that together carry over 150,000 vehicles per day. Outdoor BC concentration was measured with an Aethalometer; vehicles were counted pneumatically on two nearby streets. Meteorological data were also obtained. Missing data were imputed and all data were normalized to a 5-min observational interval (n = 105,120). Time-series modeling accounted for autoregressively (AR) correlated errors. This study found that outdoor BC was positively correlated at a statistically significant level with neighborhood-level vehicle counts, which contributed at a rate of 66 \u00b1 10 (SE) ng\/m3 per 100 vehicles every 5 min. Winds from the SW-S-SE quarter were associated with the greatest increases in BC (376-612 ng\/m3). These winds would have entrained BC from Baltimore's densely trafficked central business district, as well as a nearby interstate highway. The strong influence of wind direction implicates atmospheric transport processes in determining BC exposure. Dew point, mixing height, wind speed, season, and workday were also statistically significant predictors. Background exposure to BC was estimated to be 905 ng\/m3. The optimal, statistically significant representation of BC's autocorrelation was AR([1:6]) \u00d7 288 \u00d7 2016, where the short-term AR factor (lags 1-6) indicated that BC concentrations are correlated for up to 30 min, and the AR factors for lags 288 and 2016 indicate longer-term autocorrelations at diurnal and weekly cycles, respectively. It was concluded that local exposure to BC from mobile sources is substantially modified by meteorological and temporal conditions, including atmospheric transport processes. BC concentration also demonstrates statistically significant autocorrelation at several time scales.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20323123,"openaccessinfo":{"externalids":{"MAG":"1997114330","ACL":null,"DOI":"10.3155\/1047-3289.58.7.928","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3155\/1047-3289.58.7.928?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In Divine Holiness and Divine Action Mark Murphy seeks to establish four key claims: first, that divine holiness consists in a supreme desirability of creaturely union with God and a commensurately supreme creaturely unfittingness for that union; second, that this holiness-concept is grounded in a value-gap between God and creatures which by default motivates God to withdraw from creatures rather than love us or seek our welfare; third, that the love and concern for creaturely welfare exhibited in God's creating and redeeming is a contingent and freely chosen override of the default stance of holiness; and fourth, that God should be thanked and emulated in virtue of exhibiting a kind of humility in overriding the demands of holiness for our sakes, though not worshipped or praised for this humility, since these latter attitudes should be reserved for necessary rather than contingent features of God. I argue that each of these four claims is mistaken, and further that it is a good thing they are mistaken, because if Murphy's account were right the appropriate response to God would be neither worship nor thanks but rather abject despair.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":264534953,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.12978\/jat.2023-11.180017240021","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jat-ojs-baylor.tdl.org\/jat\/article\/download\/579\/646","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT \n \nThis paper discusses the critical technologies that are used in the development of optical wireless communication network, in the protection of the safety, and in the provision of convenience to the vision-impaired population. The technologies of the realizations of the hardware, firmware, decision algorithms, communication protocols and application programs developed for Sensor Nodes in optical wireless communication network are applied for the Smart Blind-Guidance Network System. In addition, this technology is aided by the assistant equipment (cane) for the blind and the communication interface protocol for the computer, which is specifically designed for the blind. The smart blind-guidance system is a combination of optics, microprocessor, voice acoustics, and wireless electronics. This system also possesses the functions of distance measuring and environment parameters, collecting to finish a complete Pre-warning, Guide, Alarm, Recovery and Detection (GUARD) guide system for the blind and also completing a locating and addressing system.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":227149193,"openaccessinfo":{"externalids":{"MAG":"3092275345","ACL":null,"DOI":"10.6180\/JASE.2008.11.1.03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Caffeine was examined for the effect upon the running performance on a treadmill in two trained dogs. A preliminary experiment was performed to find out running speeds at which the steady adaptation to exercise was broken up. Runs of 15-minute duration at speeds of 220 and 235 m\/min in dog 1 and at a speed of 160 m\/min in dog 2 (at a grade of 0% in both dogs) were determined to be employed in an experiment with caffeine. Caffeine was administered intravenously at single doses of 2.5, 5.0, and 7.5 mg\/kg in the form of a mixture of caffeine and sodium benzoate. Runs were started 10 minutes after administration. Caffeine improved the running performance markedly at a strenuous work rate in dog 1, even at such a small dose as 2.5 mg\/kg. On the contrary, it had an obscure performance-increasing effect on dog 2, even at such a large dose as 7.5 mg\/kg, although the dog was placed on exercise at a much lower work rate than dog 1. The effect of caffeine would be evaluated only qualitatively, because of individual differences in this effect from dog to dog.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9271066,"openaccessinfo":{"externalids":{"MAG":"3026391612","ACL":null,"DOI":"10.1292\/JVMS1939.36.81","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrostatic surface waves propagating on the plane interface between a vacuum and a cold magnetized homogeneous plasma are investigated. The surface waves resulting from two different directions of the static magnetic field, normal to the interface and parallel to the direction of wave propagation, have the same frequency provided the strength of the magnetic held is the same. Furthermore, these two surface waves are complementary to each other in the sense that when one wave has strong surface-wave characteristics the other acts like a bulk wave, and vice versa. When the magnetic field is directed perpendicular both to the direction of wave propagation and the interface normal, a non-propagating zero-frequency mode is possible, as well as the two hybrid frequencies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250745317,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0741-3335\/37\/7\/005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo screen a three-generation familial partial epilepsy with variable foci (FPEVF) family with epilepsy to identify the cHRNA4 gene (a candidate gene).\n\n\nPATIENTS AND METHODS\nA total of 18 members of the three-generation FPEVF family with partial epilepsy were selected, and 18 blood samples were collected for investigation. Among them, five members were affected by epilepsy, and another 13 members were not affected. A pedigree chart was mapped to comprehensively analyze the clinical characteristics of each member, including ictal semiology, electroencephalogram (EEG), past medical history, MRI features, neuropsychological MMSE (mini-mental state examination) scores, etc. PCR and Sanger sequencing method were used to screen the mutant gene cHRNA4.\n\n\nRESULTS\ncHRNA4 genes of all affected members were positively mutated, and that of the unaffected members were negative. The positive mutation was base A instead of base G.\n\n\nCONCLUSIONS\ncHRNA4 is the causative gene of FPEVF, and genes of the affected members are all heterozygotes mutations.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":4706838,"openaccessinfo":{"externalids":{"MAG":"2999216986","ACL":null,"DOI":"10.26355\/eurrev_201803_14594","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This is an authoritative sourcebook on a major strand of Group Relations Theory - \"learning from experience\". This approach was developed jointly from psychoanalytic and open systems theories, including those of Bion, Kegan, Klein and Freud. It will be invaluable for all those involved in working with groups and organisations.The papers in this collection look at the underlying theory and the practical application of learning from experience. They address the broad issues of authority, leadership and organisational culture, whilst concentrating on other issues in-depth, such as inter-group conflict, and gender and race relations in the workplace.Contributors:Thomas N. Gilmore; Laurence J. Gould; Larry Hirschhorn; Ross A. Lazar; Susan Long; Eric J. Miller; Debra A. Noumair; Lionel F. Stapley; and Mark Stein.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2015-11":1,"2015-18":1}},"corpusid":142970874,"openaccessinfo":{"externalids":{"MAG":"1555609586","ACL":null,"DOI":"10.4324\/9780429474415","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The method of lines, a semianalytical procedure, has become one of the standard tools for solving practical, complex electromagnetic field problems. The method of lines is used in solving axisymmetrical problems involving Laplace's equation. One numerical example is used to verify the procedure. The results obtained compare well with an analytical solution.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":60465223,"openaccessinfo":{"externalids":{"MAG":"1900841425","ACL":null,"DOI":"10.1109\/SECON.2000.845626","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bacteriophage T7 DNA primase (gene-4 protein, 66,000 daltons) enables T7 DNA polymerase to initiate the synthesis of DNA chains on single-stranded templates. An initial step in the process of chain initiation is the formation of an oligoribonucleotide primer by T7 primase. The enzyme, in the presence of natural SS DNA, Mg++ (or Mn++), ATP and CTP (or a mixture of all 4 rNTPs), catalyzes the synthesis of di-, tri-, and tetraribonucleotides all starting at the 5' terminus with pppA. In a subsequent step requiring both T7 DNA polymerase and primase, the short oligoribonucleotides (predominantly pppA-C-C-AOH) are extended by covalent addition of deoxyribonucleotides. With the aid of primase, T7 DNA polymerase can also utilize efficiently a variety of synthetic tri-, tetra-, or pentanucleotides as chain initiators. T7 primase apparently plays an active role in primer extension by stabilizing the short primer segments in a duplex state on the template DNA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2313042,"openaccessinfo":{"externalids":{"MAG":"2052004592","ACL":null,"DOI":"10.1093\/NAR\/4.12.4151","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Without any doubt communication can move people to do things which they did not want without communication. The article interrogates, why communication is able to do that, what the sources of the power of communication are \u2013 namely on the other side from violence and authority. In discussion with the sociological, communication-scientific and speech-act literature the thesis is developed that the communication power appears when the communication partners have developed a relationship of respect. In such a relationship communication possesses the power to strengthen identity or to damage. The power of communication therefore results on relationship of respect and the identity-making ability of communication.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":143893848,"openaccessinfo":{"externalids":{"MAG":"1991323497","ACL":null,"DOI":"10.1515\/comm.2011.008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background When making international comparisons of non-fatal injury, they are often based on hospital data, and are contaminated by health service effects. One way to reduce this contamination is to make comparisons using a case definition based on diagnoses that have high probabilities of admission. Aim To identify International Classification of Diseases (ICD) diagnoses associated with a high probability of admission. Method We identified international collaborators who had access to Emergency Department data whose diagnoses were coded to the ICD. A protocol for data provision was agreed with our collaborators. The submitted data was checked by the New Zealand team and then via liaison with the collaborators. Country-specific results were presented at the ICD 4- character level. Results were also contrasted between countries. Results The results show that the only injuries with strong evidence for high probabilities of admission, consistently across all collaborating countries, were fractured neck of femur and other femoral fractures (S720, S721, S722 and S723). Other injuries that were potentially consistent with high probabilities, but for which the estimates had wide CIs due to small numbers in some of the collaborators data, included: focal brain injury (S063), traumatic haemopneumothorax (S272), injury of the spleen (S360), liver or gall bladder (S361). Outcome The information generated by this project will inform all high income countries of those diagnoses that almost always get admitted to hospital. It will also suggest a case definition suitable for making international comparisons.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":73389068,"openaccessinfo":{"externalids":{"MAG":"2130350509","ACL":null,"DOI":"10.1136\/ip.2010.029215.506","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/injuryprevention.bmj.com\/content\/injuryprev\/16\/Suppl_1\/A141.3.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Modeling and simulation of photovoltaic (PV) systems are open research areas since\u00a0I-V and P-V curves are commonly required to analyze the performance of PV\u00a0installations. To obtain such curves commercial software packages can be used, however\u00a0the connection type and size of the PV array may cause large simulation times. To\u00a0overcome such an issue several techniques based on analyzing the inflection points have\u00a0been proposed to model the PV array with the aim of reconstruct accurately the required\u00a0electrical curves. However, such analysis has been applied only for series-parallel (SP)\u00a0configuration, which is just one alternative to connect PV arrays among several other\u00a0regular or irregular options. Therefore, a more general approach is needed. This paper\u00a0presents an approach to obtain the characteristics curves for any PV array, regular or\u00a0irregular, by extending the inflection points analysis. Then, the calculation of the PV\u00a0array electrical curves is simplified by using equivalent circuits within the intervals\u00a0defined by the inflection points. Such a procedure is based on defining which modules\u00a0become active due to the behavior of the bypass diodes. Finally, the proposed approach\u00a0enables to analyze any PV array without requiring long electrical simulations. The\u00a0solution was validated by means of simulation results obtained in Matlab\u00ae.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":111639263,"openaccessinfo":{"externalids":{"MAG":"2748555149","ACL":null,"DOI":"10.22430\/22565337.187","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/revistas.itm.edu.co\/index.php\/tecnologicas\/article\/download\/187\/193","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The issue of zakat distribution to the poor and needy is still prevalent today although these rightful recipients deserve the assistance as provisioned by Islam. Zakat distribution methods that fulfil the objective of the syariat (maqasid al syariah) have often been debated since such methods are indispensable in the syariat zakat. Despite of its importance, few studies have dealt with this pertinent issue. In view of this, this study set out to identify the best mechanism of zakat distribution for the poor and needy that meets the main objective of the established syariat zakat which is to attain the minimum quality of life. This study, also, aimed to identify factors that affect the success and failure of the zakat recipients in improving their livelihood. This study focused on three objectives, namely: (i) to identify the mechanism of zakat distribution management that could aid the poor and needy asnaf to attain a minimum quality of life in line with the objective of the zakat distribution, (ii) to establish a minimum standard for the poor and needy's quality of life based on the objective of the zakat distribution and (iii) to identify factors that affect the success and failure of the poor and needy in utilizing the zakat sources in their endeavour to improve their livelihood. The research framework for this study was formed based on the maslahah concept pioneered by al-Ghazali and al-Syatibi who advocate that every syariat in Islam secures a benefit and prevents harm to human lives. Othman al-Habsyi applied the maslahah concept through his theory of just equitable distribution of wealth in Islam. In tandem with the aim and objectives of this research, the researcher employed qualitative data collection. Data were collected through archival documentation, interviews and indirect observation. The study sample included 14 people, mainly employees of the Kedah zakat management, participants of the Jayadiri \nZakat aid programme and specialists in fields related to the study. The research found that the entrepreneurial aid scheme in the form of tools provided succeeded in helping the participants moved out of poverty and attained the minimum quality of life.The minimum quality of life concept was also established based on several measurement methods which included (i) attaining comfortable life (2) rising above the poor and needy phase and (3) having income more than the nisab level. Forms of distribution, attitude and monitoring were identified as factors that affected the success and failure of the zakat recipients in transforming their standard of living. The research further concluded that in order to obtain the zakat distribution objective, specifically for the poor and needy, the three objectives obtained could become a determinant component to zakat distribution management.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":107802167,"openaccessinfo":{"externalids":{"MAG":"196867551","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We succeeded in synthesizing of a whole family of isostructural solvates of the copper(II) hexafluoroacetylacetonate complex with pyrazolyl-substituted nitronyl nitroxide (L): Cu(hfac)2L x 0.Solv. The main feature inherent in nature of Cu(hfac)2L x 0.5 Solv single crystals is their incredible mechanical stability and ability to undergo reversible structural rearrangements with temperature variation, accompanied by anomalies on the mu(eff(T)) dependence. Structural investigation of the complexes over a wide temperature range before and after the structural transition and the ensuing magnetic phase transition showed that the spatial peculiarities of the solvent molecules incorporated into the solid govern the character of the mu(eff(T)) dependence and the temperature region of the magnetic anomaly. Thus, doping of crystals with definite solvent molecules could be used as an efficient method of control over the magnetic anomaly temperature (T(a)). The investigation of this special series of crystals has revealed the relationship between the chemical step and the magnetic properties. It was shown that \"mild\" modification of T(a) for Cu(hfac)2L x 0.5 Solv required a much smaller structural step than the typical change of one -CH2- fragment in a homologous series in organic chemistry. Quantum-chemical calculations with the use of X-ray diffraction data allowed us to trace the character of changes in the exchange interaction parameters in the range of the phase transition. In the temperature range of the phase transition, the exchange parameter changes substantially. The gradual decrease in the magnetic moment, observed in most experiments during sample cooling to T(a), is the result of the gradual increase in the fraction of the low-temperature phase in the high-temperature phase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40411834,"openaccessinfo":{"externalids":{"MAG":"1978183130","ACL":null,"DOI":"10.1021\/ic8011074","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract In this research, four different silver powders with specific sizes and shapes were used in order to produce photosensitive silver paste. The produced silver paste was checked in order to see whether its rheological properties and its micro-conductive pattern specific to the touch panel were well embodied. Moreover, the conductance of the paste, with reference to its drying system, was evaluated. As a result, the lowest resistance was achieved when the particle mean diameter was D50=0.8\u223c1.0\u03bcm, which also produced the highest pattern sharpness. The drying system where IR\/IR method was used for both pre-drying and post-drying processes resulted in the lowest resistance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":138791927,"openaccessinfo":{"externalids":{"MAG":"2554901361","ACL":null,"DOI":"10.14226\/KSIST.2014.21.2.03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ENGLISH) This study is to determine whether using project management with process reengineering technique in the process of preparing Akaun Awam in Administrative Central Operation and Agency Division, Accountant General Department can speed the process of preparing and submission of Akaun Awam to the Auditor General. Case study approach was conducted in the research using rational model of decision making to determine technique that can produce Akaun Awam that have the highest quality in term of information timeliness, accuracy, quantity and relevance. Data was collected using documents checking, distribution of questionnaires, interview and observation. Findings of the study shows that the use of project management with process reengineering technique speed up the process of preparing Akaun Awam by 22 hours if compare with using the current technique which take up 701 hours. This process reengineering also takes into account quality in term of information accuracy, quantity and relevance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56089500,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Syringomas are benign tumors of adnexal origin, and eruptive syringoma is an extremely rare subtype. In this paper, we present a case of a unusual occurrence of eruptive syringoma in 66-year old woman that includes clinical and pathohistological findings and the review of the clinical picture, diagnosis, and treatment options.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17482638,"openaccessinfo":{"externalids":{"MAG":"2208435786","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper concerns with the production of synthetic phasor measurement unit (PMU) data for research and education purposes. Due to the confidentiality of real PMU data and no public access to the real power systems infrastructure information, the lack of credible realistic data becomes a growing concern. Instead of constructing synthetic power grids and then producing synthetic PMU measurement data by time simulations, we propose a model-free approach to directly generate synthetic PMU data. we train the generative adversarial network (GAN) with real PMU data, which can be used to generate synthetic PMU data capturing the system dynamic behaviors. To validate the sequential generation by GAN to mimic PMU data, we theoretically analyze GAN's capacity of learning system dynamics. Further by evaluating the synthetic PMU data by a proposed quantitative method, we verify GAN's potential to synthesize realistic samples and meanwhile realize that GAN model in this paper still has room to improve. Moreover it is the first time that such generative model is applied to synthesize PMU data.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-30":1,"unknown":2}},"corpusid":54462280,"openaccessinfo":{"externalids":{"MAG":"2969736569","ACL":null,"DOI":"10.1109\/SGSMA.2019.8784681","PubMedCentral":null,"ArXiv":"1812.03203"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Growth retardation nearly invariably accompanies hypophosphatemic rickets. Studies were conducted in an adolescent male with this disorder as follows. Protocol I: age, 6 to 16 years; treatment per day, 5,000 to 80,000 units vitamin D2, 1,760 to 2,200 mg phosphorus, orally as buffered phosphate; growth velocity, 5 to 6 cm\/year. Protocol II: age 16 to 17 years; treatment per day, 1 alpha,25-dihydroxyvitamin D3, 1 microgram; 2,200 mg of phosphorus, orally as buffered phosphate; growth velocity, 14 cm\/year. The height improved from less than third percentile for the decade during study protocol I to the 25th percentile during protocol II. Mineral balance studies showed a reduction of urinary and stool phosphorus during treatment protocol II, while the patient was receiving metabolic diet. The serum phosphorus improved from 2.2 to 4.3 mg\/dl and radiologic healing of rickets was documented. No hypercalcemic episode was encountered. The data support the contention that 1 alpha,25-dihydroxyvitamin D3 is the treatment of choice for hypophosphatemic rickets.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":71064944,"openaccessinfo":{"externalids":{"MAG":"1832040138","ACL":null,"DOI":"10.1542\/peds.64.4.488","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective Korean Neuropsychiatric Association changed the Korean name of schizophrenia from 'Split-mind Disorder' to 'Attunement Disorder' in 2012. This study assessed attitudes towards the renaming of schizophrenia among mental health practitioners (n=440), patients with schizophrenia and their guardians (n=396), and the university students (n=140) using self-administered questionnaires. Methods The questionnaire included items related to participants' perception of the renaming of the disease, the nature of informing about the disease to confirm the effect of the name change. Results It was confirmed the notification rate of disease name by mental health practitioners was increased significantly after the renaming. Among patients and their guardians, 24.9% and 15.0%, respectively, perceived their own or the family member's illness as 'attunement disorder'. Conclusion Patients and their guardians continue to display a low awareness about the name of the disease as 'attunement disorder.' However, mental health practitioners were found to be able to easily use the name 'attunement disorder' as a result of the increased notification rate of the new disease name.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":51710042,"openaccessinfo":{"externalids":{"MAG":"2884890484","ACL":null,"DOI":"10.30773\/pi.2018.02.18.2","PubMedCentral":"6056692","ArXiv":null},"license":null,"url":"http:\/\/psychiatryinvestigation.org\/upload\/pdf\/pi-2018-02-18-2.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract The wind velocities measured by an aircraft flying parallel and perpendicular to jet streams (Project Jet Stream, 1956\u20131957) have been analyzed; a smoothing technique has been used to separate the meso-scale turbulence from the mean flow. Eulerian auto-correlation coefficients and energy spectra are computed for the longitudinal and transversal components of the horizontal wind velocities. The distributions of the auto-correlation coefficients and the energy spectra appear to be similar for both the longitudinal and transversal components of the velocities, whereas the corrected meso-scale energy spectrum increases with decreasing wave number and is approximately proportional to k\u22122 in the range between 10\u22121 cycles km\u22121. An analysis is also made of the distribution of the Richardson number in a cross section perpendicular to the jet stream. A good relationship is found between the areas of turbulence and the regions of small Richardson number.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":121612977,"openaccessinfo":{"externalids":{"MAG":"2032044077","ACL":null,"DOI":"10.1175\/1520-0469(1964)021<0513:ESOMST>2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose : To investigate whether siRNA targeting viral protein 5 (VP5) can become a new treatment for herpes simplex virus type 1 (HSV-1). Methods : Flow cytometry was performed to determine the ratio of siRNA and lipo2000 to reach the highest transfection efficiency. Western blot and q-PCR were performed to determine the knockdown efficiency of siRNA targeting UL19, as well as changes in cytoskeleton proteins. Plaque reduction assays and confocal microscopy were conducted to test the influence of VP5 knockdown on the HSV-1 life cycle and viral replication. F-actin organization was observed through confocal microscopy during HSV-1 infection when transfected with siRNA. Results: Relative expression level of the UL19 gene dropped to 6 % while plaque formation inhibition rate rose to 85 % compared with virus control. Knocking down VP5 expression abrogated the changes to F-actin that were induced by HSV-1 infection. Conclusion: Interfering with UL19 gene expression inhibits HSV-1 replication efficiently in vitro. The results indicate that the major capsid protein VP5 encoding gene UL19 may be a promising target for RNA interference-based therapeutic strategy against HSV-1. Keywords: siRNA, Viral protein 5, Herpes simplex virus type 1, Gene expression, Propagation, Cytoskeleton rearrangement, F-actin, Transfection","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":37024336,"openaccessinfo":{"externalids":{"MAG":"2141673989","ACL":null,"DOI":"10.4314\/TJPR.V14I3.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In order to quantitatively study the influence of tailings fine content on the properties of cemented paste backfill (CPB) and further understand themechanism of tailings fine content acting, the concept of packing density was introduced in this study.+e packing density of each tailings sample was measured by the wet packing method after the samples with various fine contents were prepared. Moreover, CPBs with different tailings fine contents were tested by the mini slump test, rheological test, uniaxial compressive strength (UCS) test, and mercury intrusion porosimetry test. +e results demonstrated that the flow spread and UCS both increase first and then decrease with the increase of tailings fine content, while the yield stress shows an opposite trend. +e fine content of tailings affects the flowability of fresh CPB mainly through the packing density. When the fine content is high, the influence of the specific surface area of tailings cannot be ignored.+e packing density is an important factor affecting the strength of CPB, and there is an obvious linear relationship between the packing density and UCS.+e pore structure of CPB samples with different tailing fine contents is significantly different, and the macroscopic packing density changes the strength of CPB by affecting the microscopic pores.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235719316,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Baida, F.C., D.C. Santiago, L. H. I. Vidal, L. C. Baida, C. T. Stroze. 2011. Medicinal Plants' Hosting Ability for Nematode Suitability Meloidogyne incognita and M. javanica. Nematropica 41:150-153. Medicinal plants can be attacked by pests, diseases and nematodes, which can compromise the quality and quantity of their healing properties and their yield. The aim of this study was to analyse the reaction of 15 medicinal plant species to the nematode Meloidogyne spp. The seedlings were produced by seed germination or cuttings under greenhouse conditions. A completely random experimental pattern of 15 treatments and 10 replications was chosen for the study. The seedlings were inoculated with approximately 5000 eggs + J 2 \/plant 20 days after planting. Plant height and fresh and dry leaf weight, were measured 60 days after planting. The roots were collected, thoroughly washed and stained with Philoxine B and then processed to extract the eggs to determine the reproduction factor. For M. incognita the results showed that Chamomile was susceptible with RF = 1,64 making it a good host, and the other plants were resistant (RF < 1), and for M. javanica that all the plants showed resistance (RF < 1), Myrrh, Rue and Balsam demonstrating immunity (RF = 0).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264282503,"openaccessinfo":{"externalids":{"MAG":"2406414649","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background and aims: Esophageal cancer (EC) is a deadly disease with poor survival rates of only \u223c10%. The EC incidence remains highest in the Shanxi and Henan regions near the Tang Hang Mountain area in Northern China. In endemic esophageal squamous cell carcinoma (ESCC) regions, common familial clustering and historical migration patterns suggest an inherited ESCC genetic susceptibility. We hypothesize that cancer predisposition gene(s) (CPGs) carrying rare deleterious variants play a crucial role in ESCC genetic susceptibility and aim to identify the underlying CPGs of familial ESCC from Henan by applying the targeted sequencing approach. Methods: Our discovery set utilized NGS technology to capture a comprehensive gene panel critical for ESCC by targeted re-sequencing of 1271 selected genes (11 Mb) and sequenced for the germline variants in the blood DNA from 222 familial ESCC individuals and 124 Henan non-cancer controls. Familial ESCC was defined as at least two family members developed ESCC. The custom designed panel contains a cancer panel of 578 gene list (4Mb) and a custom list of 693 (7Mb) ESCC-specific genes derived from various approaches including microarray profiling in FH+ ESCC primary tissues, homozygosity-by-descent (HBD), SNP array-based analysis by both GWAS and candidate gene approaches of our own set of MassArray SNP association data. The data from 346 individuals were processed using the analysis pipeline following the GATK guideline. Briefly, raw fastq reads were mapped using the Burrows-Wheeler Aligner (BWA). PCR duplicates are marked using Picard. The raw variants are called by GATK HaplotypeCaller using a joint genotyping of all samples. Results: Preliminary data analysis for the 346 samples resulted in the final call set comprised of 52328 rare variants. There are 26486 rare variants present in the 222 FH+ ESCC cases, but absent in the 124 controls. The average sequencing coverage was 88X. Principal component analysis (PCA) and multidimensional scaling (MDS) indicated a homogenous population structure between the case and the control populations. Targeted re-sequencing results of the 1271 selected genes in 222 familial ESCC individuals identified a recurrent missense variant in AIM1L (Absent in Melanoma 1-like) in 14\/222 (6.3%) of FH+ ESCC patients but absence in the 124 non-cancer control. Data obtained by a melting curve-based genotyping platform by LC480 and LightSNiP assay for high throughput validation of this recurrent SNP in larger sample cohort are underway and will be presented. Conclusions: A SNP in AIM1L may be associated with higher risk for ESCC in Henan and validation in larger cohort is required. The data may provide valuable insight for understanding genetic susceptibility to this deadly cancer. Acknowledgements: We acknowledge the Asian Fund for Cancer Research for grant support. Citation Format: Josephine Mun Yee Ko, Lu wen Ni, Sheyne, Sta Ana Choi, Lisa Chan Lei, Li Dong Wang, Maria Li Lung. Rare deleterious germline mutations of candidate genes associated with risk of familial esophageal squamous cell carcinoma (ESCC) by targeted sequencing. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5234.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":89418264,"openaccessinfo":{"externalids":{"MAG":"2500772984","ACL":null,"DOI":"10.1158\/1538-7445.AM2016-5234","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The temperature\/doping dependent phase diagram of ferroelectric perovskite oxides is shown to be characterized by six different temperature scales: (1) At high temperatures a crossover from paraelectric to paraelectric\/ferroelastic behavior sets in followed by (2) the onset of fluctuating ferroelastic clusters with doping- and temperature-dependent size. (3) The cluster size anti-correlates with their total system volume which defines another temperature scale. (4) The onset of ferroelectricity is not sharp since para- and ferroelectric solutions coexist in a small temperature regime. (5) The ferroelectric phase shows novel effects since beyond a certain transition temperature this state is incomplete, i.e., ferroelastic clusters fluctuate in a polar matrix. Finally (6) for low enough temperatures, ferroelectricity is completely suppressed by quantum fluctuations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122838330,"openaccessinfo":{"externalids":{"MAG":"2080008036","ACL":null,"DOI":"10.1080\/00150190902844882","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Data assimilation has been applied in several studies [Montabone et al., 2005; Lewis et al., 2005; Montabone et al., 2006a; Montabone et al., 2006b; Lewis et al., 2007; Wilson et al., 2008; Rogberg et al. 2010] as an effective tool with which to analyze spacecraft observations and phenomena (e.g., atmospheric tides, transient wave behavior, effects of clouds in the tropics, weather predictability, etc.) in the Martian atmosphere. A data assimilation scheme combined with a Martian Global Circulation Model (GCM) is able to provide a complete, balanced, four-dimensional solution consistent with observations. \n \nThe GCM we use [Forget et al., 1999] combines a spectral dynamical solver and a tracer transport scheme developed in UK and Laboratoire de Meteorologie Dynamique (LMD; Paris, France) physics package developed in collaboration with Oxford, The Open University and Instituto de Astrofisica de Andalucia (Granada, Spain). \n \nHere, we describe and discuss dust-related interannual and intraseasonal variability of the Martian climate. The results shown in this study come from a reanalysis using the Martian GCM with data assimilation scheme which assimilates Mars Global Surveyor\/ Thermal Emission Spectrometer (MGS\/TES) retrievals of temperature and column dust opacity. The detailed model setup was described by Montabone et al. [2006a], and the data assimilation scheme employed in this study was introduced in the work of Lewis et al. [2007].","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":7871914,"openaccessinfo":{"externalids":{"MAG":"1659085859","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate the effects of heterogeneous mobility on rate adaptation and user scheduling in cellular networks with hybrid automatic repeat request (HARQ). To this end, we first show the performance tradeoff between two extreme scheduling criteria: retransmission-oriented scheduling (ROS) and mixed scheduling (MS) criteria over time-correlated Rayleigh fading channels. Then, we propose an ROS-based joint rate adaptation and user scheduling (JRAUS) policy for cellular networks and compare it with the conventional and reference JRAUS policies. We also evaluate the system-level performance of the proposed ROS-based JRAUS policy in various user distribution and mobility scenarios. In particular, in an asymmetric user distribution and heterogeneous mobility scenario, which is the most general one in practice, the proposed JRUAS policy yields a throughput gain of 49% and a fairness gain of 155% over the conventional JRAUS policies. In this paper, we find that the rate adaptation is significant not only in a single point-to-point link but in multiuser systems with heterogeneous mobility as well.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":9172981,"openaccessinfo":{"externalids":{"MAG":"2025174111","ACL":null,"DOI":"10.1109\/TVT.2013.2250533","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\u2014 Fetal and neonatal atrioventricular (AV) reentrant tachycardias can be life-threatening but resolve in most cases during the first year of life. The transient presence of accessory AV myocardial connections during annulus fibrosus development may explain this phenomenon. Methods and Results\u2014 A total of 45 human embryonic, fetal, and neonatal sectioned hearts (4 to 36 weeks of development) were studied immunohistochemically. Accessory myocardial AV connections were quantified and categorized according to their specific location, and 3D reconstructions were made. Between 4 and 6 weeks of development, the atrial and ventricular myocardium was continuous at the primitive AV canal. At 6 to 10 weeks, numerous accessory myocardial AV connections were identified in the left (45%), right (35%), and septal (20%) regions of the AV junction. Most right-sided accessory connections comprised distinct myocardial strands, whereas left-sided connections consisted of larger myocardial continuities. At 10 to 20 weeks, all accessory AV connections comprised discrete myocardial strands and gradually decreased in number. The majority of accessory connections were located in the right AV junction (67%), predominantly in the lateral aspect (45%). Seventeen percent of the accessory connections were observed in the left AV junction, and 16% were observed in the septal region. 3D reconstructions of the developing AV nodal area at these stages demonstrated multiple AV node\u2013related accessory connections. From 20 weeks until birth, and in neonatal hearts, no further accessory myocardial AV connections were observed. Conclusions\u2014 Isolation of the AV junction is a gradual and ongoing process, and right lateral accessory myocardial AV connections in particular are commonly found at later stages of normal human cardiac development. These transitory accessory connections may act as substrate for AV reentrant tachycardias in fetuses or neonates.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":16800754,"openaccessinfo":{"externalids":{"MAG":"2081918088","ACL":null,"DOI":"10.1161\/CIRCULATIONAHA.107.756288","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Apple (Malus x domestica) is one of the important fruit crops of the world. It is mainly cultivated in temperate regions. Apple fruit contains many health beneficial compounds which may play an important role in reducing cancer cell proliferation and lowering the level of cholesterol. Apple production can suffer from several pests and diseases and among them scab is very important. Apple scab is a fungal disease caused by Venturia inaequalis. The pathogen is a facultative saprophyte that grows during the growing season subcuticularly on the host. Most of the present day high quality apple cultivars are susceptible to apple scab. The crop loss due to apple scab has been amount to more than 70%. Fruit growers usually spray fungicides 15 times or more in a season to control the scab disease. To reduce the use of chemicals, it is absolute necessary to develop apple varieties with durable scab resistance. Conventional breeding in apple has some drawbacks such as long generation period, genetic drag and the self-incompatible sexual reproduction system. Therefore, stacking of more than one resistance gene by classical introgression breeding is inefficient. Genetic modification is an alternative option to improve the existing scab-susceptible varieties into scab-resistant ones. However, consumer acceptance of transgenic food in Europe is a problem. Therefore, we developed a genetic modification system with cisgenes and intragenes instead of transgenes. Cisgenes are genes from the plant itself or from crossable species with their natural introns and own regulatory elements in normal sense orientation. Intragenes are like cisgenes containing only functional parts of genes from the plant itself or from crossable species, however, these functional parts originate from different genes. All these genes or gene parts are belonging to the normal breeder's gene pool. Transgenes are synthetic genes or (partly) origination from non-crossable species, like viruses and microorganisms. Transgenes are representing a new gene pool for plant breeding. GMO-regulations have been developed for transgenes. Societal research showed that consumer preference for cisgenic food is higher than for transgenic food. Cisgenic or intragenic plants can be developed by transferring the desired scab resistant genes into the scab-susceptible cultivar through Agrobacterium tumefaciens-mediated transformation. Transformation aimed at cisgenesis or intragenesis should be done either without the use of selectable marker genes or by using selection markers first and eliminating them subsequently after selection of transformants. In this thesis almost all steps have been made to come to cisgenic apple plants with resistance to scab disease (chapter 2). Although many scab resistance genes have been identified and mapped, only Vf has been positionally cloned. Vf is a locus with four paralogs namely HcrVf1 (Homologues of Cladosporium fulvum resistance genes of Vf region), HcrVf2, HcrVf3, and HcrVf4. Only HcrVf1 and HcrVf2 are considered as being functional. In conventional breeding Vf inherits as a single locus so it is not possible to study the individual role of HcrVf1 and HcrVf2 in conferring resistance against scab using conventionally bred material. The present study was set up to study in depth the roles of HcrVf1 and HcrVf2 separately in conferring resistance to apple scab, using A. tumefaciens mediated transformation. Both isolated genes were regulated as cisgenes by their own promoter and terminator sequences. The two cisgenes were used in two different lengths of the 5'-upstream sequences, so with a short promoter (SP) and a long promoter (LP) i.e. 312 bp and 1990 bp for HcrVf1 and 288 bp and 2000 bp for HcrVf2. HcrVf1 and HcrVf2 were also combined with the apple rubisco promoter and terminator into intragenes because these regulatory elements were found to give high expression in plants. The HcrVf1 and HcrVf2 cisgenes and intragenes were inserted into the susceptible cv. 'Gala', using the marker free system pMF1. Several apple transformants were selected for further characterization. Micrografting was carried out in order to take the 'in vitro' transformants to the greenhouse. This method proved to promote growth better than rooting of 'in vitro' transformants. Apple transformant 'in vitro' shoots were used as scions and grafted onto the apple seedling rootstocks. Micrografts were ready for further testing 4 to 5 weeks after grafting. At this stage the young leaves were collected for isolation of DNA and RNA. Southern hybridization was performed to check the inserted T-DNA copy number. For this, the selection marker gene nptII was used as a probe. Most of the transformants (17) were found to have a single T-DNA insert and seven transformants showed two T-DNA inserts. Subsequently, HcrVf gene expression in transformed lines was studied through quantitative RT-PCR (qRT-PCR) in relation to the natural HcrVf expression in the resistant cv. 'Santana'. In case of HcrVf1 transformants, expression by LP was significantly higher than by SP, while in HcrVf2 transformants no significant difference between SP and LP could be demonstrated. Both HcrVf1 and HcrVf2 genes showed highest expression when regulated by the apple rubisco promoter and terminator. Two HcrVf2 transformants, LPHcrVf2-4 and PMdRbcHcrVf2-12, showed the highest gene expression for the cisgene and intragene situation, respectively. Among HcrVf transformants, no significant correlation was observed between inserted gene copy number and gene expression level (Chapter 3). Micrografted cvs. 'Santana' (resistant control containing Vf through classical breeding), 'Gala' (susceptible control) and different micrografted apple transformants were tested for scab resistance against V. inaequalis isolate EU-B05. The top four leaves were Summary 125 used for inoculation with V. inaequalis. Seventeen days after inoculation, the plants were scored for sporulation using a quantitative scale. All the HcrVf1 transformants showed complete sporulation similar to the level in cv. 'Gala', indicating that HcrVf1 is not giving resistance. On the other hand, 10 out of the 13 HcrVf2 transformants showed resistance at levels that were statistically similar to cv. 'Santana'. Two HcrVf2 transformants, LPHcrVf2-4 and PMdRbcHcrVf2-12, showed the best resistance. A negative correlation between HcrVf2 gene expression and sporulation was observed i.e. as gene expression increased there was a decrease in the fungal sporulation (Chapter 4). The results obtained by the scab experiment were used to select HcrVf1 and HcrVf2 transformants to check the resistance spectrum against different isolates of V. inaequalis. The plants were inoculated with four avirulent isolates of the pathogen and two isolates virulent to the resistant cv. 'Santana'. The top two leaves were inoculated with fungal spores and the inoculated plants were scored for sporulation 21 days after inoculation. All the HcrVf1 transformants showed heavy sporulation of all the isolates used and they were behaving like untransformed cv. 'Gala'. The HcrVf2 transformants were behaving like cv. 'Santana' indicating that the resistance coming from the Vf gene cluster is from HcrVf2 alone (Chapter 5). In order to increase the durability of resistance against scab, it is desired to stack several resistance genes into apple cultivars either by classical breeding or by genetic modification. To use it in a cisgenic or intragenic approach, new scab resistance genes have to be identified in apple and cloned. In chapter 6 it is described how a novel scab resistance gene, Vd3, has been identified and genetically mapped in the resistant selection \"1980-015-025\". In the study we used the F1 progeny 2000-012 that is derived from the crossing between the resistant parent 1980-015-025 and the susceptible parent 1973-001-041. Mainly DArT markers were used in this genetic mapping study. Other known markers, such as SSRs, P-136 (RAPD marker), and Vf2ARD (RGA marker), were used for annotation of the linkage groups. The Vd3 gene has been mapped 1 cM to the south of the Vf gene cluster in repulsion phase on linkage group 1. Paternity tests have indicated that clone 1980-015-025 has inherited the Vd3 gene from founder accession D3. This gene can provide resistance against the virulent isolate EU-NL24, which can overcome the resistance of Vf and Vg. However, this gene cannot provide resistance against other isolates (Chapter 6). The results described in this thesis are of practical importance. Cisgenesis or intragenesis can be employed to provide multiple gene resistance against scab in apple without linkage drag problems as observed during classical introgression breeding. Our first potential cisgenic scab resistant 'Gala' plants with the HcrVf2 gene are being developed which can be used in regions free of virulent isolates. The cisgenic approach is essential in rapid improving a crop such as apple where it takes many decades through conventional breeding.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":89277530,"openaccessinfo":{"externalids":{"MAG":"2551168898","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study intended to examine the effect of monetary policy on economic growth of selected SAARC countries. Inorder to fulfill these objectives analysis is based on panel data over 25 years of period from 1996 to 2020 of selected five SAARC nations. Economic growth is measured by GDP per capita growth where exchange rate, inflation, broad money to GDP, external reserve are used as monetary policy variables. The Descriptive and casual relationship research design has been used using secondary data. Hausman test is run to select between the fixed and random effect model and correlation matrix is used in this study to summarize the relationship between variables. Among the variables, external reserve, broad money was found to have positive significant effect on GDP while exchange rate has negative significant effect. Also, inflation was found to have negative insignificant effect on economic growth at 5% level of significance. This study concludes that the inability of monetary policies to effectively maximize their policy objectives most of the time is due to flaws in the policy instruments used, which limits their contribution to growth even though monetary policies have made impressive contributions over the years.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":258229439,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3126\/ljbe.v10i1-2.54210","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.nepjol.info\/index.php\/ljbe\/article\/download\/54210\/40559","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Asymmetric oxidation catalysis with an aluminum-based complex was achieved by a combination of newly synthesized chiral aluminum(salalen) complexes (salalen = half-reduced salen = salan\/salen-hybridized [ONNO]-type tetradentate ligand; salan = reduced salen, salen = N,N'-ethylenebis(salicylideneiminato)) derived from binol (1,1'-bi-2,2'-naphthol) with aqueous hydrogen peroxide as the oxidant. The combination was found to be efficient for asymmetric sulfur oxidation. Various sulfides were smoothly converted into the corresponding sulfoxides with high to excellent enantioselectivity. Thioacetals are also good substrates for the oxidation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40933303,"openaccessinfo":{"externalids":{"MAG":"2156189213","ACL":null,"DOI":"10.1002\/asia.200700328","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This report describes work performed by ECD to advance its roll-to-roll, triple-junction photovoltaic manufacturing technologies; to reduce the module production costs; to increase the stabilized module performance; and to expand the commercial capacity utilizing ECD technology. The 3-year goal is to develop advanced large-scale manufacturing technology incorporating ECD's earlier research advances with the capability of producing modules with stable 11% efficiency at a cost of approximately $1\/W[sub p]. Major efforts during Phase I are (1) the optimization of the high-performance back-reflector system, (2) the optimization of a-Si-Ge narrow band-gap solar cell, and (3) the optimization of the stable efficiency of the module. The goal is to achieve a stable 8% efficient 0.3-m [times] 1.2-m (1-ft [times] 4-ft) module. Also, the efforts include work on a proprietary, high-deposition-rate, microwave plasma, CVD manufacturing technology; and on the investigation of material cost reduction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":136656797,"openaccessinfo":{"externalids":{"MAG":"1641093212","ACL":null,"DOI":"10.2172\/6805606","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/servlets\/purl\/6805606","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a novel approach to equivalence verification of RT-level descriptions. The proposed approach sacrifices exactness in favor of applicability: it is not always able to produce an answer, but it is able to check sequential equivalence of large systems. Furthermore, being based on commercial VHDL tools, it does not have arbitrary limitations in the syntax of the descriptions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56556924,"openaccessinfo":{"externalids":{"MAG":"1565459883","ACL":null,"DOI":"10.1109\/ICECS.1999.812295","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effect of guanidine hydrochloride on creatine metabolism of uremic rat was studied. Significant changes were observed in the creatine profiles of liver, kidney and muscle as a function of guanidine hydrochloride.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32683710,"openaccessinfo":{"externalids":{"MAG":"2405101146","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In present study, Silver nanoparticles (AgNPs) were synthesized using peel Raphanus sativus L extract that acts as a reducing and stabilizing agent. The AgNPs formation was observed as a color change of the mixture from red to dark-brownish we have developed a green synthetic method for silver nanoparticles using peel of R. sativus extract. Silver Nanoparticle prepared were characterized by using UV\u2013visible spectroscopy, Scanning electron microscopy(SEM), X-ray diffraction (XRD) and Dynamic light scattering (DLS). The best Condition of experiments includes temperature 50\u00b0C, pH 9, time 0.5 h, sliver nitrate concentration 1 mM and mixing ratio of the reactant on sliver nanoparticles synthesis 5:95. The AgNPs showed surface plasmon resonance at 430 nm, size ranges from 34 nm to 50 nm determined by using a laser particle size analyzer (DLS).","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":55194041,"openaccessinfo":{"externalids":{"MAG":"2613880812","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Osteoarthritis is the main cause of disability and pain. Due to limited understanding of the disease mechanism, it is generally difficult to diagnose early and eliminate sequelae. The aim of this study was to identify novel biomarkers for osteoarthritis (OA) using a bioinformatics approach.\n \nMethod: The gene expression dataset GSE82107 were obtained from the Gene Expression Omnibus (GEO) database. Matrix quality assessment was performed using corrplot packages and principal component analysis. The differentially expressed genes (DEGs) picked out using GEO2R tool. Enrichment analyses were performed using The Database for Annotation, Visualization and Integrated Discovery and Gene Set Enrichment Analysis (GSEA). Weighted correlation network analysis (WGCNA) was used to find gene modules highly associated with OA. Cytoscape with Molecular Complex Detection (MCODE) plug-in was utilized to analyze protein-protein interaction of these DEGs. Receiver operator characteristic curve analysis was used to evaluate the diagnostic effectiveness of genes.\n \nResults: Samples with different conditions (HC and OA) are obviously distinguished, and the distance between biological replicates is relatively close. In total, 1676 DEGs were identified. Enrichment analysis showed that there were some gene sets related to OA pathology, such as chondrocyte development. The results of WGCNA analysis showed that 298 genes were most positive associated with OA. 10 common genes obtained were selected as candidate core genes. ROC results showed that 5 of these genes had the greatest diagnostic value.\n \nConclusion: This is the first study to identify biomarkers related to OA by combining multiple algorithms such as GSEA, WGCNA, MCODE and ROC. We suggest that GLG1, PAPSS2, CTSK, TIMP1 and SDC1 could serve as valuable biomarkers. Further studies are needed to examine the precise role and mechanism of these genes in OA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":234901475,"openaccessinfo":{"externalids":{"MAG":"3115510411","ACL":null,"DOI":"10.21203\/rs.2.21759\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.2.21759\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Iron chelators have been shown to control the growth of cancer cells in culture by sequestering exogenous iron in the media. Thus, the ligands prevent cellular access to the metal. However, because transferrin provides iron to tumor cells in animals, chelators have not been effective antitumor agents. Polyamine chelator conjugates in which the polyamine vectored ligands into cells were far more active than the free chelators themselves. However, the free ligands were not released from the vector once in the cell. The current study focuses on the synthesis and preliminary evaluation of a polyamine chelator conjugate capable of releasing the free ligand intracellularly via a nonspecific esterase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29818762,"openaccessinfo":{"externalids":{"MAG":"1972947446","ACL":null,"DOI":"10.1055\/S-0030-1258245","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fluorescent proteins are widely used to visualize structures and dynamics in various biological samples. Multiphoton microscopy is especially suitable for imaging structures expressing fluorescent proteins with subcellular resolution. 3-photon microscopy (3PM) excited at the 1700-nm window has proven to be promising for deep-tissue (such as brain) imaging expressing red fluorescent proteins. However, the 3-photon excitation and emission spectra of fluorescent proteins suitable at this window remain largely unknown, hampering protein selection and detection optimization. Here we demonstrate detailed measurement of 3-photon excitation and emission spectra for selected fluorescent proteins, suitable for 3-photon excitation at the 1700-nm window. The measured 3-photon excitation spectra will provide guidelines for protein and excitation wavelength selection. The measured 3-photon emission spectra and comparison with the 1-photon emission spectra, on one hand proves that the fundamental Kasha's rule is still valid for 3-photon fluorescence in these fluorescent proteins, on the other hand will be helpful for efficient fluorescence signal detection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145023389,"openaccessinfo":{"externalids":{"MAG":"2938314559","ACL":null,"DOI":"10.1364\/OE.27.012723","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present study was conducted to determine the effects of different dietary protein levels and recombinant porcine somatotropin (rpST) administration on deposition rates of protein, fat, water, ash, and collagen in pigs. Ten groups of six barrows (30 kg BW) were restrictively fed (80% of ad libitum) one of five diets containing 11, 15, 19, 23, or 27% CP. Diets were isoenergetic and all contained equivalent amounts of lysine. Thirty barrows were treated daily with rpST (100 micrograms\/kg) by i.m. injection; remaining pigs were treated with diluent for 42 d. At all levels of dietary protein intake, carcass and empty body accretion rates of protein, water, and ash were greater in rpST-treated pigs than in respective controls. The magnitude of change elicited by rpST was lowest in pigs consuming 11% CP. Administration of rpST resulted in a 34% decrease in the accretion rate of fat; increasing protein intake resulted in a linear decrease in fat accretion in control and rpST-treated pigs. Accretion rates of protein, water, ash, and fat were increased in viscera of rpST-treated pigs compared with respective controls; rates of visceral protein and water accretion were increased as dietary protein was increased, whereas deposition of fat was decreased in control and rpST-treated pigs. Administration of rpST resulted in an overall 66% increase in the utilization efficiency of dietary protein for empty body protein deposition. Protein intake had minimal effect on the concentration of collagen in the carcass; however, rpST treatment increased concentrations of total and soluble collagen by 30 and 33%, respectively. Recombinant pST had little influence on collagen crosslinking or maturation. Deposition rate of carcass collagen was increased 63% in rpST-treated pigs compared with respective controls.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33811001,"openaccessinfo":{"externalids":{"MAG":"2418477926","ACL":null,"DOI":"10.2527\/1991.69104019X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The development of efficient electrocatalysts for the oxygen evolution reaction (OER) is critical for the generation of renewable energy carrier hydrogen from water splitting. Recently, metal oxides derived from metal nitrides, sulfides, chalcogenides, and phosphides have been demonstrated to exhibit superior catalytic activity as electrocatalysts for the OER but otherwise are difficult to gain access to by conventional metal oxidation methods. In this work, we demonstrate a novel in situ chemical etching process of Ni(OH)2 nanosheets followed by a thermal ammonolysis process to fabricate iron\u2013nickel nitride Ni3FeN supported by pure Ni metal. Ni3FeN is not stable and would be converted partially into NiFeOOH under oxygen-evolution conditions, forming a NiFeOOH\/Ni3FeN\/Ni heterojunction showing extraordinarily high activity for the OER in alkaline medium with a low overpotential of 200 mV at 10 mA cm\u22122 and a Tafel slope of 36 mV dec\u22121. We demonstrated that NiFeOOH is the major active material while Ni3FeN\/Ni could help increase the charge transfer dramatically. More importantly, the presented NiFeOOH\/Ni3FeN\/Ni catalyst has extremely good durability. This work provides a new strategy for the synthesis of metal and metal oxide heterojunctions for efficient electrocatalysts for the oxygen evolution reaction.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":225533151,"openaccessinfo":{"externalids":{"MAG":"3034537299","ACL":null,"DOI":"10.1039\/d0cy00689k","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traditional power grids are mainly based on centralized power generation and subsequent distribution. The increasing penetration of distributed renewable energy sources and the growing number of electrical loads is creating difficulties in balancing supply and demand and threatens the secure and efficient operation of power grids. At the same time, households hold an increasing amount of flexibility, which can be exploited by demand-side management to decrease customer cost and support grid operation. Compared to the collection of individual flexibilities, aggregation reduces optimization complexity, protects households' privacy, and lowers the communication effort. In mathematical terms, each flexibility is modeled by a set of power profiles, and the aggregated flexibility is modeled by the Minkowski sum of individual flexibilities. As the exact Minkowski sum calculation is generally computationally prohibitive, various approximations can be found in the literature. The main contribution of this paper is a comparative evaluation of several approximation algorithms in terms of novel quality criteria, computational complexity, and communication effort using realistic data. Furthermore, we investigate the dependence of selected comparison criteria on the time horizon length and on the number of households. Our results indicate that none of the algorithms perform satisfactorily in all categories. Hence, we provide guidelines on the application-dependent algorithm choice. Moreover, we demonstrate a major drawback of some inner approximations, namely that they may lead to situations in which not using the flexibility is impossible, which may be suboptimal in certain situations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247899573,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/en15072501","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/15\/7\/2501\/pdf?version=1648542204","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Non\u2010equilibrium molecular dynamics simulations of a solvated 21\u2010residue polyalanine (A21) peptide, featuring a high propensity for helix formation, have been performed at 300 K and 1 bar in the presence of external electromagnetic (e\/m) fields in the microwave region (2.45 GHz) and an r.m.s. electric field intensity range of 0.01\u20130.05 V\/\u00c5. To investigate how the field presence affects transitions between the conformational states of a protein, we report 16 independent 40 ns\u2010trajectories of A21 starting from both extended and fully folded states. We observe folding\u2010behavior of the peptide consistent with prior simulation and experimental studies. The peptide displays a natural tendency to form stable elements of secondary structure which are stabilized by tertiary interactions with proximate regions of the peptide. Consistent with our earlier work, the presence of external e\/m fields disrupts this behavior, involving a mechanism of localized dipolar alignment which serves to enhance intra\u2010protein perturbations in hydrogen bonds (English, et al., J. Chem. Phys. 2010, 133, 091105), leading to more frequent transitions between shorter\u2010lifetime states. \u00a9 2012 Wiley Periodicals, Inc.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35943983,"openaccessinfo":{"externalids":{"MAG":"2045705216","ACL":null,"DOI":"10.1002\/jcc.22912","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Significant reductions in the size and cost of a fusion power plant core can be realized if simultaneous improvements in the energy replacement time, , and the plasma pressure or beta, can be achieved in steady-state conditions with high self-driven, bootstrap current fraction. Significant recent progress has been made in experimentally achieving these high performance regimes and in developing a theoretical understanding of the underlying physics. Three operational scenarios have demonstrated potential for steady-state high performance, the radiative improved mode, the high internal inductance or high scenario, and the negative central magnetic shear, NCS (or reversed shear) scenario. In a large number of tokamaks, reduced ion thermal transport to near neoclassical values, and reduced particle transport have been observed in the region of negative or very low magnetic shear: the transport reduction is consistent with stabilization of microturbulence by sheared flow. There is strong temporal and spatial correlation between the increased sheared flow, the reduction in the measured turbulence, and the reduction in transport. The DIII-D tokamak, the JET tokamak and the JT-60U tokamak have all observed significant increases in plasma performance in the NCS operational regime. Strong plasma shaping and broad pressure profiles, provided by the H-mode edge, allow high beta operation, consistent with theoretical predictions; and normalized beta values up to simultaneously with confinement enhancement over L-mode scaling, , have been achieved in the DIII-D tokamak. In the JT-60U tokamak, deuterium discharges with negative central magnetic shear have reached equivalent breakeven conditions, .","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250812913,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0741-3335\/39\/12B\/005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a graph-based semi-supervised learning method for accurate prediction of cancer prognosis. Our method consist of two parts, one is about transforming mRNA microarray data into graph data structure for learning and the other is about predicting the class labels of unlabeled samples using cost function. As a result, we achieved that our method has outstanding accuracy compared to other methods in the prognosis related cancer data which have many unlabeled samples.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":195293692,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Concussion is an emerging public health concern, but care of patients with a concussion is presently unregulated in Canada. Methods: Independent, blinded Google Internet searches were conducted for the terms \"concussion\" and \"concussion clinic\" and each of the Canadian provinces and territories. The first 10 to 15 concussion healthcare providers per province were identified. A critical appraisal of healthcare personnel and services offered on the provider's Web site was conducted. Results: Fifty-eight concussion healthcare providers were identified using this search methodology. Only 40% listed the presence of an on-site medical doctor (M.D.) as a member of the clinical team. Forty-seven percent of concussion healthcare providers advertised access to a concussion clinic, program, or center on their Web site. Professionals designated as team leaders, directors, or presidents among concussion clinics, programs, and centers included a neuropsychologist (15%), sports medicine physician (7%), neurologist (4%), and neurosurgeon (4%). Services offered by providers included baseline testing (67%), physiotherapy (50%), and hyperbaric oxygen therapy (2%). Conclusions: This study indicates that there are numerous concussion healthcare providers in Canada offering diverse services with clinics operated by professionals with varying levels of training in traumatic brain injury. In some cases, the practices of these concussion clinics do not conform to current expert consensus guidelines.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":20887718,"openaccessinfo":{"externalids":{"MAG":"2327568921","ACL":null,"DOI":"10.1097\/JSM.0000000000000305","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Consider the problem of identifying important factors influencing a response in a simulation experiment where the number of factors is large. When the direction of the effect of factors is known, the method of sequential bifurcation is effective for quickly removing non-influential factors. Though good, the method is not fully efficient in that not all the information available is fully utilized. We present a method based on a polytope construction that makes use of all available information and which is therefore more efficient. In this paper we focus on the deterministic case to highlight its theoretical foundation. The method can however be extended to the stochastic case. Numerical examples are given comparing the new method with sequential bifurcation showing its improved performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14591352,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"E-currency is a form of digital currency that employs encryption to safeguard transactions, limit the manufacture of new units, and verify asset transfers. Bitcoin exchange rates and returns are the primary subjects of this study. In order to measure volatility, the standard deviation of logarithmic returns is determined. This study used a special test to determine whether or not the data were normal. Findings of high volatility were also made using a plot, a statistical process control chart, and other methods. Normality test (casual test) has been investigated accordingly to approve and validate the results. The F-test has been considered as the main indicator for the validity of the results. It has been based on the F-value of 9.3. As well as the financial performance has been done using the time and currency with upper and lower limits. The maximum limit is 34 with a G-value of 0.34. Furthermore, market return-based e-currency has been investigated and analyzed using free and fixed limits for both main variables time and currency. According to these data, the greatest value is 23 in fixed limit circumstances, while it is 18.4 in broad trend cases. The financial performance-based ANP method has been examined using the ANP approach with return values for the currency. The upper limit reached 544 with 0.43 as a G-value. An increasing number of people are valuing volatility. Because of the present high level of volatility, investing in Bitcoin is seen as a high-risk endeavor. The purpose of this study is to assist investors in developing a strategy that maximizes returns while minimizing risk","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":248869773,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15587\/1729-4061.2022.254839","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/journals.uran.ua\/eejet\/article\/download\/254839\/252831","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The paper focuses on the development and implementation of a Java-based Web application to enhance and further material circulation and recycling conscious manufacturing activities. The Web-based application was developed rapidly by an intelligent and optimal supply chain model. The application will enable a zero emission society throughout continuous product service and maintenance activities between suppliers and agents concerning recycling and material circulation. The paper proposes a new perspective on improving product service and maintenance by effective utilization of feedback information on recycling in the whole product life cycle stage. To develop an analytical model and tools suitable for effective and profitable life-cycle maintenance modeling, simulation optimization techniques are considered, and diagnosis based on alarm conditions and acknowledging warning indicators is also developed to continuously improve energy consumption and lessen environmental impacts. A Windows-based rapid prototype system for Web-based application is suggested by using Java and AI programmable languages.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110628974,"openaccessinfo":{"externalids":{"MAG":"2139484287","ACL":null,"DOI":"10.1109\/ECODIM.2001.992362","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The maxillary dental arch of a partial cranium of an adult specimen of Australopithecus robustus shows the presence of a supernumerary tooth between the right first and second incisors. The fossil specimen, SK 83, is from Swartkrans Member 1 sediments, considered, on the basis of associated fauna, to be approximately 1.7 million yr old. The specimen was analyzed macroscopically, stereomacroscopically and by X-ray computed tomography. The anatomic position and the morphology of the tooth are consistent with a diagnosis of supernumerary lateral incisor rather than a mesiodens or a retained deciduous tooth. This is the first description of a supernumerary tooth found in Plio-Pleistocene hominid fossils from South African cave deposits.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42382790,"openaccessinfo":{"externalids":{"MAG":"2022144482","ACL":null,"DOI":"10.1046\/J.0909-8836.1999.EOS107501.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The article is dedicated to the experimental investigation of the neologisms' status in the mental lexicon of the person. The main object of the analysis was the associative reactions of the individuals to the new loanwords, which are often used in mass media speech, gathered during the conduction of the free association experiment. The focus is on the investigation of the neologisms' semantics, types of associative connections, and features of the functioning of these units from the aspect of psycholinguistics and linguistic and cultural studies. Psycholinguistic aspects of the process of neologizing and strategies to identify the new word's meaning are observed. An experimental study proves that the perception of neologisms occurs with the use of universal identification strategies. A new word as a unit of a person's internal lexicon wants to comprehend new realities that are in constant dynamics, which are a means of access to the individual's information base and requires comprehensive research. Learning a new word plays an important role in restructuring the connections between the units of the speaker's lexicon. Its renewal takes place to develop the knowledge of new associative connections, to restructure, to occur the new individual contents, and to fill a single vocabulary with new perceptual-affective contents. Neologisms that are in the final stages of assimilation by the recipient language have more varieties of associative reactions than little-used neologisms stimulus. When analyzing the results of the experiment, a distinction should be made between a neologism of its own and a word that is simply new to the speaker and that has not occurred before in individual speech experience. The analysis of the results of the experiment shows that the objective novelty of neologisms does not always coincide with the subjective novelty of stimuli perceived by informants. The internal form plays a significant role in the perception and understanding of neologisms. All the diverse information carried by a new language unit interacts with a complex system of individual and collective norms and assessments, their frequency and scope of use, and the age of acquisition and is stored with a certain set of strategies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":260079493,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17721\/2520-6397.2023.1.04","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.17721\/2520-6397.2023.1.04","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background People with a learning disability (LD) are three times more likely to die at a younger age than the overall population (Heslop, Blair, Fleming, et al., 2013). Furthermore, they may experience inadequate end of life care through providers not recognising or considering individual needs (Care Quality Commission, 2016). Two LD champions were appointed, to examine how we support more people in the community from this marginalised group. Aim(s) Increase accessibility for people with LD to receive coordinated, personalised, end of life care. Identify gaps in knowledge of hospice staff. Methods Hospice peer review conducted by LD self-advocacy group. Opinions of LD providers and professionals canvassed. Presentations delivered through community engagement emphasising objectives. Outcomes Information pack produced, and training developed for hospice staff and volunteers. End of life care education scheduled for LD professionals. Easy\u2013 read literature review, funds granted to adapt hospice information. 24 LD care home staff accessed 'Palliative Care Champions' training. Interactive Dying Matters event for people with profound, multiple LD. Staff trained in Makaton. University partnership creating diversity\/inclusion initiatives and research proposals. Development of regional LD palliative care network. Recognised as a 'Safe Place.' Feedback from people with learning disabilities: '\u2026they are true learning disability champions, passionate and committed to getting the service right for everyone.' 'The hospice is already a friendly place and I can see it getting more disability friendly.' Conclusions The project has addressed inequalities from this marginalised group's experience. The programme is ongoing, ensuring people with a LD receive fair, accessible, inclusive end of life care, now and in the future.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86472750,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjspcare-2018-hospiceabs.62","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/spcare.bmj.com\/content\/bmjspcare\/8\/Suppl_2\/A23.2.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract. \n Aoraki denticulata, a widespread mite harvestman endemic to the NW South Island of New Zealand, was postulated to constitute an old lineage with deep genetic history. Expanding on previous studies, we explored its genetic diversity and population structure, phylogeography and diversification patterns. We also examined the systematic implications of such a complex scenario through species delimitation analyses under coalescent-based and barcoding gap discovery methodologies. Our results depict the deep evolutionary history of the A. denticulata lineage, which shows high geographic structure and low genetic connectivity among modern populations. Aoraki denticulata is further subdivided into three lineages: a lineage presently inhabiting the northern region of the Southern Alps (and including the subspecies A. d. major), a second lineage in the north-eastern part of the sampled land, and a third one occupying the south-eastern localities. When using species delimitation methods based on coalescence approaches, large numbers of cryptic species were estimated. Based on morphological and biological evidence, we thus argue that these methods may overestimate species in cases in which genetic divergence is unusually large and discuss the systematic implications of our findings.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86119761,"openaccessinfo":{"externalids":{"MAG":"2162744774","ACL":null,"DOI":"10.1071\/IS14009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The notion of a community of inquiry has been treated by many of its proponents as being an exemplar of democracy in action. We argue that the assumptions underlying this view present some practical and theoretical difficulties, particularly in relation to distribution of power among the members of a community of inquiry. We identify two presuppositions in relation to distribution of power that require attention in developing an educational model that is committed to deliberative democracy: (1) openness to inquiry and readiness to reason, and (2) mutual respect of students and teachers towards one another. Our contention is that these presuppositions, presented as preconditions necessary to the creation of a community of inquiry, are not without ideological commitments and dependent upon the ability of participants to share power. Using group dynamic theories and the ideas of Hannah Arendt, we argue that behaviours commonly interpreted as obstacles to dialogue or reflective inquiry could provide opportunities for growth.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":141383964,"openaccessinfo":{"externalids":{"MAG":"1999178410","ACL":null,"DOI":"10.1111\/j.1469-5812.2007.00389.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A prerequisite in using conventional statistical methods, like regression models in land-use changes model, is that the data analyzed with these methods should be statistically independent and identically distributed. But spatial data, like land-use data, have a tendency to be dependent (spatial autocorrelation), which means that when using spatial models, a part of the variance may be explained by neighbouring values. In other words, values over distance may be more similar or less similar than expected for randomly associated pairs of observations. This indicates that standard multiple regression models cannot capture all the spatial autocorrelative characteristics in the data. Spatial dependency contains useful information but the appropriate methods have to be used to deal with it. To overcome this defect, correlograms of the Moran's I are used to describe the spatial autocorrelation for data of Ongniud Banner. And in this paper, mixed regressive-spatial autoregressive models (spatial lag models), which incorporate both regression and spatial autocorrelation, were constructed. The following results were obtained:(1) Positive spatial autocorrelation was detected not only between dependent variables but also between independent variables, indicating that the occurrence of spatial autocorrelation was highly dependent on the aggregation scale.(2) The Moran's I decreased with the increase of the aggregation levels, a result of the non-linear smoothing character between Moran's I and distance.(3) The residuals of the standard regression model also showed positive autocorrelation,indicating that the standard multiple linear regression model failed to consider all the spatial dependencies in the land use data.(4) The mixed regressive-spatial autoregressive models (spatial lag models) yielded residuals without spatial autocorrelation but with a better goodness-of-fit.(5) The mixed regressive-spatial autoregressive model was statistically sound in the presence of spatially dependent data, in contrast with the standard linear model.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":132996079,"openaccessinfo":{"externalids":{"MAG":"2388526997","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An iterative eduction procedure has been developed to study coherent structures in blunt-base cylinder wakes at 0 and 10 deg angles of attack to an M = 2.46 freestream flow. The eduction procedure uses an initial wavelet pattern to find candidate coherent structures of a particular scale and then uses the average intensity pattern of the educed structures to create an updated pattern. This iterative procedure continues until the average structure converges, indicating that a self-consistent intensity pattern has been described. Using this eduction procedure, the average appearance of the structures is described. Moreover, a convection velocity measurement is made by directly tracking individual coherent structures, unlike conventional imaging-based convection velocity measurements, which are not conditioned on coherent structures. The evolutionary trends of the structures are also quantified. The coherent structure averages show many of the same trends found in more conventional autocorrelation analysis. For example, the structures are inclined toward the freestream flow direction, and the angle of this inclination is affected by the recompression and reattachment processes. Convection velocity measurements show that the convection velocity is dependent on the transverse position of the structure in the shear layer, particularly for small structures. Finally, the coherent structures evolve in such a way that they become poorly representative of the average coherent structure pattern within 5-15 \u03bcs after being first identified.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":121600099,"openaccessinfo":{"externalids":{"MAG":"2036801668","ACL":null,"DOI":"10.2514\/1.29221","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Criteria indicating injury of endothelial cells (craters, protrusion, denudation) in saphenous veins for aorto-coronary bypass grafting have been examined and quantitated by use of light-(LM), scanning electron (SEM) and transmission electron microscopy (TEM). The specimens were fixed either by immersion or under pressure. It was shown that the conventional way of handling saphenous vein grafts prior to implantation results in serious damage of the endothelial lining. The factors responsible are presumed to be hypoxia, manual flushing and distension with isotonic saline for blood removal, control of leakage, and counteracting spasm of the graft. Even samples collected by a \"no touch\" technique and exposed to a short hypoxic interval sometimes revealed slight injury.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7480935,"openaccessinfo":{"externalids":{"MAG":"2439233651","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The term \"mineral matter\" in coal is defined as all inorganic, non-combustible material that is in or associated with coal which include discrete crystalline mineral particles, dissolved ions and other inorganic components in the pore water or surface water of the coal, and inorganic elements combined within the organic compounds of the coal macerals. The minerals existing in coal are a result of processes that occur throughout the entire history of coal formation. Its distribution is influenced by biological, hydrological and geochemical factors. Quartz and the clay minerals are the most widespread and abundant mineral found in coal. Another common minerals are feldspars and carbonate in the form of siderite, calcite and dolomite and sulfide minerals such as pyrite. Coal mineral matter analysis and characterization are useful for various reasons, particularly to take as much as benefit from coal utilization and to avoid any negative influence of coal inorganic components to the environment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201028036,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 49-year-old woman with primary Sj\u00f6gren syndrome initially developed pulmonary venous hypertension (PVH) due to heart failure with preserved ejection fraction. Endomyocardial biopsy specimens showed mild myocardial fibrosis. Pulmonary arterial hypertension (PAH) was revealed after the treatment with diuretics. During the treatment for PAH using upfront combination with pulmonary vasodilators and immunosuppressants, the patient developed combined disease with PAH and PVH. A careful hemodynamic assessment is necessary in such cases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29337089,"openaccessinfo":{"externalids":{"MAG":"1871340703","ACL":null,"DOI":"10.3109\/14397595.2015.1059989","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In numerous studies, information and communications technology (ICT) has been shown to be an enabler of service innovations in human-centered service systems (HCSSs). The resulting findings, however, have not been presented in a systematic way. Therefore, we present an integrated and representative overview of the literature on ICT-enabled service innovation in HCSSs. To show the existing findings, we reviewed papers from top journals in the fields of management science, information systems, service research, and innovation management. By using a systematic literature review, we identified 37 relevant papers. We systematically assessed the papers based on an analytical framework that consists of a four-phase management process and the components of service systems. We showed that the research background and the research methods used in the papers are very diverse, representing a large research field with a varying degree of \nknowledge. Based on our findings, we derived a specific agenda for future research.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":31537667,"openaccessinfo":{"externalids":{"MAG":"2559962854","ACL":null,"DOI":"10.2139\/SSRN.3159136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Physics is a subject that is considered difficult for students and this often leads to misconceptions. One of the factorscausing difficulties is the complexity of both abstract and real physics so it requires mastery of mathematical concepts andcreative thinking. In relation to the problem, this study aims to examine and develop Apposite Model (Application step instructionand elaboration) to improve the ability of physics concept, on kinematics motion material. Validation results of both contentvalidation and the Apposite Model construct are feasible to use. The research design used pre test - post test one group design. Thesample in this research is Physic students at Departement of Physics Education, University of Jember year 2015\/2016. Data wereanalyzed using gain score (Hake) and Anova test. The results of data analysis show that the effectiveness of the model is amoderate category, but the improvement of learning ability is significant. The conclusion of this research, Apposite Model canimprove mastery of physics concept of student on kinematics motion material.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":67188122,"openaccessinfo":{"externalids":{"MAG":"2740758989","ACL":null,"DOI":"10.18535\/IJSSHI\/V4I8.01","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"List of illustrations List of tables Notes on contributors Preface Prologue: Lawrence Stone - as seen by others 1. The myth and the man Julian Mitchell 2. The enfant terrible? C. S. L. Davies 3. 'Il Magnifico' Miriam Slater 4. The eminence rouge? John M. Murrin Part I. The Crown, The Aristocracy and The Gentry: 5. Lineage and kin in the sixteenth-century aristocracy: some comparative evidence on England and Germany Judith J. Hurwich 6. Public ceremony and royal charisma: the English royal gentry in London, 1485-1642 R. M. Smuts 7. County governance and elite withdrawal in Norfolk, 1660-1720 James M. Rosenheim 8. The last Hanoverian sovereign?: the Victorian monarchy in historical perspective, 1688-1988 David Cannadine 9. The gentrification of Victorian and Edwardian industrialists Richard Trainor Part II. Power and Social Relations: 10. Poverty and progress in early modern England A. L. Beier 11. Ambiguity and contradiction in 'the rise of professionalism': the English clergy, 1570-1730 Michael Hawkins 12. Bourgeois revolution and transition to capitalism Robert Brenner 13. Crowds, carnival and the state in English executions, 1604-1868 Thomas W. Laqueur 14. Interpersonal conflict and social tension: civil litigation in England, 1640-1830 C. W. Brooks 15. Church and state allied: the failure of parliamentary reform of the universities, 1688-1800 John Gascoigne Part III. Urban Society and Social Change: 16. Resistance to change: the political elites of provincial towns during the English Revolution Roger Howell, Jr 17. The London Wings and the Exclusion Crisis reconsidered Gary S. De Krey 18. Cultural life in the provinces: Leeds and York, 1720-1820 J. Jefferson Looney 19. The dynamics of class formation in nineteenth-century Bradford Theodore Koditschek 20. The community perspective in family history: the Potteries during the nineteenth century Marguerite Dupree Epilogue Appendix Index.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":154412181,"openaccessinfo":{"externalids":{"MAG":"2042426329","ACL":null,"DOI":"10.2307\/2542382","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Urticaria is a common disorder that adversely affects quality of life; work\u2010related and recreational activities are restricted, while rest, sleep, and emotions are seriously disturbed in a significant proportion of patients. The pathogenic mechanisms vary, but cutaneous mast\u2010cell activation with release of histamine and other vasoactive or proinflammatory mediators is thought to be the final common pathway for lesion induction in most cases. A subsequent, but incompletely understood, late\u2010phase allergic reaction seems to prolong the inflammatory process, particularly in certain chronic forms of the disorder. Although histamine is considered an important mediator of urticaria, additional substances, including the cysteinyl leukotrienes (LTs), are putative mediators of the immediate urticarial responses and the inflammatory events that follow in some types of urticaria. A second\u2010generation antihistamine, mizolastine, which exhibits dual activity with selective H1\u2010receptor antagonism and, as shown in animal studies, anti\u20105\u2010lipoxygenase activity, represents an advance in the treatment of urticaria. It has rapid, potent and sustained action. At the recommended 10\u2010mg dose, mizolastine suppresses the histamine\u2010induced wheal reaction as early as 1\u2003h after oral administration. Compared to placebo, mizolastine significantly reduces overall patient discomfort and pruritus in patients with chronic idiopathic urticaria. Double\u2010blind, placebo\u2010controlled studies have also shown mizolastine to be at least as effective as other second\u2010generation antihistamines. Furthermore, with long\u2010term use of mizolastine over 1 year, a reduction in pruritus and the number of urticarial episodes was maintained with no evidence of tachyphylaxis or tolerance. Mizolastine has also been shown to be an effective treatment for cold\u2010induced urticaria, causing significant delay in the whealing response to the ice\u2010cube test and also reducing the wheal diameter.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2508796,"openaccessinfo":{"externalids":{"MAG":"2061134008","ACL":null,"DOI":"10.1034\/j.1398-9995.2000.00804.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Data from the 1992 wave of the Health and Retirement Study are used to examine the incidence of job displacement among workers ages 51 through 60. The average displaced worker experiences a loss in earnings of 39%. Households which contain a displaced worker have incomes 24% lower than the household of an average worker. Little of these lost earnings are replaced through pension income. The rate of health insurance coverage is 16% lower among displaced workers. As with other labor market outcomes, non-Whites on average are the most economically vulnerable following displacement.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43221119,"openaccessinfo":{"externalids":{"MAG":"2134121743","ACL":null,"DOI":"10.1093\/GERONT\/38.1.7","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Section 39(2) of the Constitution of the Republic of South Africa, 1996, recognises the existence of rights not protected in the bill of rights. The South African bill of rights protects human conduct and interests extensively. Before the AMCU judgment was delivered, no clear example of a right not protected by the bill of rights had been identified in case law and legal literature. In the AMCU case the constitutional court deviated from previous judgments by holding that the interests of employees not to be dismissed unfairly is not covered by the right to fair labour practices in section 23(1) of the constitution. The court based its finding on textual and contextual interpretive considerations. Its interpretation of section 23(1) was not sound. A narrow, grammatical approach, namely that the text of section 23(1) does not refer expressly to such a right, cannot be followed when the meaning of open-ended constitutional phrases like \"fair\" labour practices is determined. And an extra-textual reference to the protection of the right in ordinary law is not relevant when the meaning of a constitutional provision is determined. Aspects of human dignity and physical and psychological integrity cannot be removed from the protective ambit of the bill of rights because they are protected by ordinary rules of the law of delict and criminal law. Viewed contextually with the other provisions of the bill of rights, the constitutional right to fair labour practices, like the right to access to housing, food, health and social services, children's rights and criminal and civil procedural rights, protects other constitutional rights in a particular field, in this case in the field of labour relations. Apart from the fact that it can hardly be contested that every employee has a vital interest not to be dismissed unfairly, many other rights, for example, to human dignity, physical and psychological integrity, economic activity, association and audi alteram partem, may be limited factually by dismissals and dismissal procedures. The scheme and ethos of the South African bill of rights is that these special rights that overlap with the general rights are guaranteed separately. Within this context one of the ironies of the artificial exclusion of a right from the protective ambit of the special right is that its violation may, like in systems without these special rights, be challenged on the basis of the unjustifiable limitation of the general rights. A rule of thumb that the protective ambit of constitutional rights should be interpreted restrictively because the application of the weak rational relationship test as part of the rule of law serves the separation of power principle better than the application of the stricter reasonable test for the limitation of constitutional rights (in the separate concurring judgment of Theron J) is questionable. Whereas legality as part of the rule of law is always complied with when the weak rationality relationship exists, reasonableness in terms of section 36 does not always amount to the application of a stricter test. The existence of a very compelling purpose (to combat a pandemic that threatens life and limb) or a factually slight limitation of a right (to stop at a stop sign) could be the basis of a conclusion that the limitation is justifiable when the weak rational relationship test is complied with. The court's consideration of proportionality under the umbrella of the application of the weak rational relationship test causes more uncertainty in the present somewhat unruly field of the application of rationality tests.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":238023622,"openaccessinfo":{"externalids":{"MAG":"3178100559","ACL":null,"DOI":"10.47348\/tsar\/2021\/i1a9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to develop an efficient mold structure for the injection molding of a subminiature lens, using shell-type runners instead of traditional cylindrical runners. While the shell runner has the advantage of shorter cooling time due to its thinner geometry, this smaller thickness causes an increase in injection pressure. In this study, the design of the shell runner was modified to contain multiple holes for the purpose of reducing injection pressure. Numerical analyses were performed for shell runners of various hole-shapes, and the resulting filling and cooling characteristics were discussed; the rhombic hole showed the best result for both filling and cooling characteristics. Subsequently, injection molding experiments were performed using an injection mold fabricated based on the rhombic design. The lens parts were successfully molded with highly-reduced cycle time and without degradation of part quality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":111213251,"openaccessinfo":{"externalids":{"MAG":"2225527958","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Teak (Tectona grandis L.f.) is a tree species was almost cultivated for log produced in Java, Indonesia. The purpose this research was to identified the influence of cocomulsa application for growth of teak seedling on the field. Cocomulsa was made from coconut-fiber use latex glue. Cocomulsa can take hold of soil moisture and can defend the weeds movement. Treatments in this research that are using of stake, herbicide, and hoe. The results of this study that interaction from stake and hoe combinations was influenced significantly to growth of plant circumference and high. Based on normality test, that occur disseminating of high and circumference average value to following date normality line, in where average\u00a0 of high and circumference significant toward growth of teak. The result of calculation from minitab software indicate that the growth ofe teak seedling was not significant. That is because of unless the time from this research, monitoring just done in 2 months. Whereas teak is slow growing species with level of growth is long enough, so the different from that treatments have not seen in clear. Visually, teak plants with cocomulsa was better growth than teak without cocomulsa. And nominally, cocomulsa research toward growth of teak have not seen significant because of unless time for response observation from teak plant. So, in cocomulsa influence research next time that have to use fast growing species and take long time for observation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":112202856,"openaccessinfo":{"externalids":{"MAG":"2303788079","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently, deep learning methods have shown superior performance on image reconstruction and noise suppression by implicitly yet effectively learning prior information. However, end-to-end deep learning methods face the challenge of potential numerical instabilities and require complex application specific training. By taking advantage of the multichannel spatial encoding (as exploited by conventional parallel imaging reconstruction) and prior information (exploited by deep learning methods), we propose to embed a deep learning module into the iterative low-rank matrix completion based image reconstruction. Such strategy significantly suppresses the noise amplification and accelerates iteration convergence without image blurring.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":260654499,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.58530\/2022\/4347","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"For the first time, this study evaluates the contributions to systemic risk in the context of U.S. institutional prime money market funds (MMFs) from different sources using partial least squares structural equation modeling (PLS-SEM). The primary motivation behind this study is to trace systemic risk to its underlying sources and measure which types of relationships provide significant explanation using PLS-SEM. I illustrate the application of PLS-SEM and interpretation of results in a step-by-step manner to empower those new to PLS-SEM, and undertake robustness testing. Findings indicate that through crisis years, macroprudential indicators contribute to potential systemic risk more than prudential indicators. This suggests that macroprudential indicators that can be traced to individual MMFs market positions are more important in understanding systemic risk during crises, and further underlines the interconnectedness of markets. PLS-SEM can be used to test the explanatory power of new indicators as they emerge in an exploratory environment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":158434719,"openaccessinfo":{"externalids":{"MAG":"2808366900","ACL":null,"DOI":"10.4236\/TEL.2018.89098","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Normal mammalian sera have long been known to contain heat labile factors that promote the phagocytosis o~ many bacteria, but the relation of these heat l~bile opsonins (ttLO) 1 to \"natural\" antibodies, on the one hand, and to the complement (C) system, on the other, has been a matter of continuing controversy (1-13). Hirsch and Strauss (15) recently concluded from studies on rabbit serum that HLO are distinguishable from antibodies by: (a) their heat lability, (b) their constancy of liter in different serum spedmens against a variety of bacteria, (c) their rapid reaction with bacteria at 38\u00b0C, but not at 0\u00b0C, (d) their inactivation by hydrazine and ammonia, (e) their absence in the gamma globulin fraction of serum, and (f) their lark of spedticity as demonstrated by cross absorption studies. In addition, their attachment to S~#hylococc~.s alb~ was blocked by high concentrations of salt and did not require the presence of divalent cations in the medium. The latter finding led to the further conclusion that t tLO are not identical to the hemolytic complement system. In a confirmatory study, done with immunofluorescence techniques, Hirsch (15) reported that the tILO in guinea pig serum: (6) are adsorbed to the surfaces of staphylococci at 38\u00b0C, but not at 0\u00b0C, (b) are blocked in their adsorption by high salt concentration, but not by the absence of either Ca++ or Mg ++, (c) are altered or destroyed by exposure to 56\u00b0C, to hydrazine, or to trypsin, even when already adsorbed, and (6) are adsorbed independently of previously attached antibody. He concluded, therefore, that HLO are neither antibodies nor the complete hemolytic complement system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":215516302,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A series of layered divalent metal formate compounds, [M(HCOO)2(HCONH2)2] (M = Mn (1Mn), Ni (2Ni), Cu(3Cu), Zn(4Zn), Mg(5Mg)), have been prepared by solvothermal synthesis and their room temperature (RT) and low-temperature (LT) crystal structures, and thermal and magnetic properties determined. All the compounds contain octahedral metal ions connected by four anti-anti formato ligands to form (4,4) nets with the composition of M(HCOO)2. The oxygen atoms from two coordinating formamide ligands above and below the layer complete the MO6 distorted octahedral coordination. Order-disorder phase transformations involving the formamide ligands were observed in the 1Mn, 2Ni, and 4Zn compounds. Like transitions in related formate structures with perovskite like topology, the transitions correspond to the ordering of the amine groups of the terminating formamide ligands which are disordered at ambient temperature. The magnetic properties of the three magnetic members of the series 1Mn, 2Ni, and 3Cu were investigated using microcrystalline samples, over the temperature range of 2 K-300 K under different applied fields. All compounds belong to antiferromagnetic square lattices with S = 5\/2, 1, and 1\/2. Exchange constants for a nearest neighbor model are presented here. Specific heat measurements indicate magnetic long-range order at lower temperatures, S = 5\/2 (antiferromagnetic) and S = 1 (ferrimagnetic).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21083522,"openaccessinfo":{"externalids":{"MAG":"2321607256","ACL":null,"DOI":"10.1021\/ic402200v","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: Despite universal immunization programs, pertussis remains a major public health concern. This study aimed to describe the pertussis epidemiology in the Puglia region in 2006\u20132015 and to identify recent polymorphisms in Bordetella pertussis virulence-associated genes. Methods: The pertussis cases in 2006\u20132015 were identified from the National Hospital Discharge Database and the Information System of Infectious Diseases. Samples of pertussis cases in 2014\u20132016 that were confirmed by the Regional Reference Laboratory were subjected to ptxA, ptxP and prn gene sequencing and, in 10 cases, multiple-locus variable-number tandem repeat analysis. Results: In Puglia in 2006\u20132015, the pertussis incidence rose from an average of 1.39\/100,000 inhabitants in 2006\u20132013 to 2.56\u20132.54\/100,000 in 2014\u20132015. In infants <1 year of age, the incidence rose from an average of 60.4\/100,000 infants in 2006\u20132013 to 149.9\/100,000 in 2015. Of the 661 cases recorded in 2006\u20132015, 80.3% required hospitalization; of these, 45.4% were <1 year of age. Of the 80 sequenced samples, the allelic profile ptxA1-ptxP3-prn2 was detected in 74. This variant was detected in both vaccinated and unvaccinated people. Six Bordetella pertussis samples were prn deficient. The multiple-locus variable-number tandem repeat analysis cases exhibited multiple-locus variable-number tandem repeat analysis-type 27. Conclusions: The pertussis incidence in Puglia has risen. The hypervirulent strain was also found in vaccinated people. This suggests bacterial adaptation to the vaccine and raises questions about acellular vaccine effectiveness. Prevention of infant pertussis cases is best achieved by immunizing the pregnant mother. Enhanced surveillance and systematic laboratory confirmation of pertussis should be improved in Italy.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":205692275,"openaccessinfo":{"externalids":{"MAG":"2759675522","ACL":null,"DOI":"10.1097\/INF.0000000000001804","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Limonium bellidifolium (2n = 2x = 18), a perennial statice belonging to the family Plumbaginaceae, is cultivated as a garden plant or for cut flowers and is an important breeding material for the production of hybrid cultivars in the genus. In this study, chromosome doubling in L. bellidifolium was attempted to increase the variability in horticultural traits. Seeds of this species were treated with an antimitotic agent, colchicine, at different concentrations and exposure periods. The treated seeds were sown in soil in a cell tray and the seedlings were grown in a greenhouse. More than 50% of the seedlings treated with colchicine for 24 or 48 h, irrespective of the concentration, survived for 4 months after treatment. Most of the seedlings treated for 72 h at any concentration showed very poor growth and abnormal thickening of the hypocotyl, and ultimately died. The surviving seedlings were grown in 9-cm pots. Flow cytometry analysis of leaf tissues showed that 2.5%\u2013 5% of plants that received 0.05% colchicine for 72 h, 0.25% colchicine for 24 h, 0.25% colchicine for 48 h, or 0.5% colchicine for 48 h were tetraploid (4x) or mixoploid (2x + 4x). The highest frequencies of tetraploids and mixoploids occurred following treatment with 0.05% colchicine for 72 h. These results showed that colchicine treatment of seeds is effective for chromosome doubling in L. bellidifolium. After 3 years of cultivation, the morphological characteristics of diploid and tetraploid L. bellidifolium plants at the flowering stage were investigated. The stomatal density was lower in all investigated tetraploid and mixoploid plants than in the control diploid plant. The stomatal length was 1.1to 1.5-fold higher in all tetraploid and mixoploid plants than in the control. Tetraploid plants tended to have wider and thicker leaves than the control and also produced larger flowers.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":53705193,"openaccessinfo":{"externalids":{"MAG":"2314156384","ACL":null,"DOI":"10.2503\/HORTJ.MI-117","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Although physical activity (PA) has been demonstrated to reduce symptoms of depression and anxiety, research on the mental health benefits of PA in older adults is limited. Moreover, the psychosocial factors that might mediate or moderate the relationship between PA and depression in this population are largely unexplored. Methods: Using a sample of adults age 65 and older (N = 2736), we examined whether the major components of the stress process model (stress, social support, mastery, self-esteem) and physical health mediate or moderate the relationship between PA and depressive symptoms. Results: Physical health has the single largest effect, accounting for 45% of the effect of PA on depression. The stress process model, with physical health included, accounts for 70% of the relationship between PA and depression. Conclusions: Among older adults with above average levels of perceived mastery, greater physical activity is associated with higher levels of depression. Limitations and directions for further research are discussed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":260685887,"openaccessinfo":{"externalids":{"MAG":"2199557224","ACL":null,"DOI":"10.1123\/JPAH.2.1.98","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Renal ischemia reperfusion (IR) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute and chronic kidney dysfunction. IL-11 is a multifunctional hematopoietic cytokine clinically approved to treat chemotherapy-induced thrombocytopenia. Recent studies suggest that IL-11 also has potent antiapoptotic and antinecrotic properties. In this study, we tested the hypothesis that exogenous IL-11 protects against renal IR injury and determined the mechanisms involved in renal protection. Pretreatment with human recombinant IL-11 (HR IL-11) or with long-acting site-specific polyethylene glycol (PEG)-conjugated human IL-11 analog (PEGylated IL-11) produced partial but significant protection against renal IR injury in mice. In addition, HR IL-11 or PEGylated IL-11 given 30-60 min after IR also provided renal protection in mice. Significant reductions in renal tubular necrosis and neutrophil infiltration as well as tubular apoptosis were observed in mice treated with HR IL-11 or PEGylated IL-11. Furthermore, HR IL-11 or PEGylated IL-11 decreased both necrosis and apoptosis in human proximal tubule (HK-2) cells in culture. Mechanistically, IL-11 increased nuclear translocation of hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) and induced sphingosine kinase-1 (SK1) expression and activity in HK-2 cells. Moreover, selective HIF-1\u03b1 inhibitors blocked IL-11-mediated induction of SK1 in HK-2 cells. Finally, HR IL-11 or PEGylated IL-11 failed to protect against renal IR injury in SK1-deficient mice. Together, our data show powerful renal protective effects of exogenous IL-11 against IR injury by reducing necrosis, inflammation, and apoptosis through induction of SK1 via HIF-1\u03b1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10759186,"openaccessinfo":{"externalids":{"MAG":"2055830606","ACL":null,"DOI":"10.1152\/ajprenal.00220.2012","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3469680","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia with thrombosis (HITT) are rare but potentially limb- and life-threatening complications of heparin therapy. Continuation of heparin or low-molecular-weight heparin is contraindicated due to platelet activation in the presence of (heparin-dependent) HIT antibodies. Primary treatment options currently include argatroban, fondaparinux, or bivalirudin. However, the parenteral administration routes and interference of argatroban with traditional coagulation markers complicate management. The goal of this review is to assess the viability of direct oral anticoagulants as an alternative treatment option in patients with HIT\/HITT. Their use in HIT\/HITT is reasonable, given absent cross-reactivity preformed with HIT antibodies. Furthermore, their rapid onset of action and induction of effective anticoagulation provide a favorable basis for their use in this condition. Herein, we summarize 3 studies and 8 case reports comprising 56 patients in whom direct oral anticoagulants were used in the treatment of HIT\/HITT.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22393158,"openaccessinfo":{"externalids":{"MAG":"2592417517","ACL":null,"DOI":"10.1177\/1076029617696582","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029617696582","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Human Vgamma2\/Vdelta2(+) gammadelta T cells respond to low molecular-mass nonpeptide Ags in a gammadelta TCR-dependent manner. Although requirements of Ag presentation have remained controversial, we have indicated that specific responses of the primary gammadelta T cells to pamidronate were dependent on monocytic adherent cells for Ag presentation. Here, we show that human tumor cells can efficiently present aminobisphosphonate and pyrophosphomonoester compounds to gammadelta T cells, inducing specific proliferation and IFN-gamma production. gammadelta TCR dependency of the response to Ag-pulsed tumor cells was confirmed by using a Jurkat line transfected with a Vgamma2\/Vdelta2 gammadelta TCR. Furthermore, gammadelta T cells exhibited markedly enhanced cytotoxicity against the Ag-pulsed tumor cells as compared with untreated tumor cells. Survey of a number of human tumor cell lines of different origins revealed that the majority of them became susceptible for gammadelta T cell-mediated cytotoxicity following the Ag pulsing except for breast cancer lines so far examined, while normal PHA blast cells remained resistant. The results not only imply a unique mode of nonpeptide Ag recognition by human gammadelta T cells but also may provide a novel strategic clue for immunotherapy of human malignancy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27872530,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Civil structures having social, cultural heritage and architectural relevance are these where a systematic and accurate monitoring system is often needed. The nature of the events that could affect the health of a structure, such as earthquakes or severe weather phenomena,\u00a0 is \u2013 to a large extent \u2013 unknoun. The intensity of these phenomena isn't foreseeable, nor is the moment when they will occur. Restoration or reinforcement works are further situations where the static and dynamic conditions of a structure could be impaired. In all these conditions, the availability of a continuous and real time structural health monitoring is obviously useful in the detection of a potentially dangerous situation for the structure and its occupants. When it comes to historic buildings, the utility of having a health monitoring system is more evident, because of the greater fragility of these kinds of structures. Hence is the need to design a monitoring system for the main spire of Milan's Duomo.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":108656212,"openaccessinfo":{"externalids":{"MAG":"1528118161","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It has been well established within the literature that the successful implementation of quality relies heavily upon the human factor. Most leading firms now recognise that a higher quality service and improved competitiveness will result from increased attention to people issues within the organization. It is held that the implementation of any quality initiative should embrace a participatory management style, address the issue of changing attitudes and culture, employee involvement and empowerment together with investment in training, development and learning. To date, limited research attention has been given to the challenges involved in operating such practices in working contexts such as healthcare. This is significant given that it is the 'softer' issues of managing the quality dynamic that are coming to the fore in healthcare organizations. This paper seeks to explore and address such deficiencies and reports a review of key developments in this area. It concludes by outlining current research developments within the healthcare industry in Ireland and poses important questions for future quality implementation within the Irish healthcare sector.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":113212432,"openaccessinfo":{"externalids":{"MAG":"2277870977","ACL":null,"DOI":"10.1080\/1478336042000255433","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The pandemic of Covid-19 which started in the year 2019 did not just cause an effect on the living of millions of people but in the economic and social sectors of every part of the world as well. It is a challenging task to determine the interrelation between COVID-19 cases concerning the economy in the top affected countries. This paper explores; how severe Impact of COVID-19 1st wave on the economic facets of Pakistan as compared to the Top Fifteen affected countries. Moreover, this paper uses COVID-19 well-known dataset provided by John Hopkins and Stock Market Datasets collectively to carry out the critical analysis successfully. We found a relationship between the cumulative numbers of confirmed cases in each country with a declining state of countries' economies: the higher decline in the stock market indicates a higher number of confirmed cases.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":245982686,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.54692\/lgurjcsit.2021.0502204","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.54692\/lgurjcsit.2021.0502204","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background\n\nStomach adenocarcinoma (STAD) is the most common histological type of stomach cancer, which causes a considerable number of deaths worldwide. This study specifically aimed to identify potential biomarkers and reveal the underlying molecular mechanisms.\nMethods\n\nGene expression profiles microarray data were downloaded from the Gene Expression Omnibus (GEO) database. The 'limma' R package was used to screen the differentially expressed genes (DEGs) between STAD and matched normal tissues. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for function enrichment analyses of DEGs. The data of STAD cases with both RNA sequencing and clinical information of The Cancer Genome Atlas (TCGA) were obtained from Genomic Data Commons (GDC) data portal. Survival curves were analyzed by the Kaplan-Meier method, univariate Cox regression analysis and multivariate Cox regression were performed using 'survival' package. CIBERSORT algorithm used approach to characterize the 22 human immune cell composition. Gene expression profiles microarray data and clinical information were downloaded from GEO database to validate prognostic model.\nResults\n\nThree public datasets including 90 STAD patients and 43 healthy controls were used and 44 genes were differentially expressed in all three datasets. These genes were primarily implicated in biological processes including cell adhesion, wound healing and extracellular matrix organization. Seven out of 44 genes showed significant survival differences based on their expression differences. CTHRC1 and LRFN4 were eventually used to constructed risk score and prognostic model by univariate Cox regression and stepwise multivariate Cox regression in The Cancer Genome Atlas (TCGA)-STAD dataset. The group having high risk scores and the group having low risk scores had significant differences in the infiltration level of multiple immune cells including CD4 memory resting T cells, M2 macrophages, memory B cells, resting dendritic cells, eosinophils, and gamma delta T cells. Multivariate Cox regression analyses indicated that the risk score was an independent predictor after adjusting for age, sex, and tumor stage. At last, the model was verified and evaluated by another independent dataset and showed a good classification effect.\nConclusions\n\nThe present study constructed the prognostic model by expression of CTHRC1 and LRFN4 for the first time via comprehensive bioinformatics analysis, which may provide clinical guidance and potential therapeutic targets for STAD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":243441178,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-52939\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-52939\/v1.pdf?c=1603552960000","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Leukemia accounts for a third of all cancers in children under the age of 15, mostly affecting industrialized countries, being the B-precursor acute lymphoblastic leukemia (pB-ALL) the most common type. The disease commonly strikes young children at the age of two to five years, and is treated with aggressive chemotherapy. In recent decades, more effective treatments have boosted survival rates and reduced mortality for childhood leukemia. However, according to SEER data from the National Cancer Institute, the incidence of lymphoblastic leukemia (ALL) in 0-14 year-old US children increased from 2.2 per 100,000 in 1975 to 4.0 per 100,000 in 2005. This might be caused in part due to better cancer registries but there is little doubt that the real incidence of this \"modern life-style\" malignancy also rose. Hence, preventive strategies are clearly superior to any therapy improvement. Environmental exposures came into the focus of many epidemiologists who initiated a number of well-conducted studies aiming to elucidate the etiological role of infection, nuclear power-plants, background terrestrial irradiation and many other putative factors. \n \nOver the past century, infections have been regarded as the most likely cause of childhood leukemias [1]. But in general, epidemiological studies are descriptive and sometimes vary in their main conclusions. Similarly, when wild type mice were born and kept in the specific-pathogen-free (SPF) environment until moved to common infectious environment they do not to develop pB-ALL [2]. These results suggest that delayed-exposure to infection is not involved in the leukemia etiology. However, it is potentially possible that, in humans, infection-exposure favors pB-ALL in children harboring an intrinsic genetic susceptibility. Recently, germline mutations in PAX5 have been described as conferring an inherited risk for pB-ALL and pB-ALL occurs in affected children at reduced penetrance [3, 4]. \n \nTo elucidate if pB-ALL is a result of infection exposure, Pax5+\/\u2212 mice were exposed to common pathogens after being born in SPF condition. Pax5+\/\u2212 mice developed clonal pB-ALL recapitulating the clinical, histopathological and molecular features of human pB-ALL. These data represent the first proof that delayed exposure to infection can induce human-like pB-ALL in mice on the basis of inherited genetic predisposition, suggesting that a similar scenario may occur in human pB-ALL [2]. The demonstration that pB-ALL development can be established in mice by delayed exposure to infection implies that either abolishing infection or exposure to infection very early after birth will interfere with pB-ALL generation (Figure \u200b(Figure1).1). In agreement with this, Pax5+\/\u2212 mice kept under SPF environment during their lifespan did not spontaneously develop pB-ALL [2]. \n \n \n \nFigure 1 \n \nExposure to infection is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility \n \n \n \nBut the most crucial question is, how does infection exposure give rise to pB-ALL? In order to identify the mechanism of this specific pB-ALL susceptibility due to Pax5 heterozygosity under exposure to infections, we characterized both B-cell development in healthy and B-cells in leukemic Pax5+\/\u2212 mice [2]. The data showed that monoallelic loss of Pax5 promotes leukemogenesis by creating an aberrant IL7-sensitive progenitor compartment. This pre-leukemic preB cell population is susceptible to malignant transformation through accumulation of secondary Jak3 mutations, which depicts a rescue mechanism of the IL7\/IL7R\/STAT5 signaling. Transplantation experiments demonstrate that the activating Jak3 mutations per se are sufficient to drive leukemia. Thus targeting the deregulated JAK\/STAT pathway can be a promising therapy for this disease. \n \nPatients with a genetic predisposition (Pax5 c.547G>A) loose the WT PAX5 allele related to a secondary structural aberration of chromosome 9p. In mice we face the same scenario but the sequence is reverse. The mice lack one Pax5 allele and acquire Pax5 point mutations on the remaining WT allele as a secondary event. The net result in both species is reduced transcriptional activity of Pax5 (Figure \u200b(Figure1).1). The mechanisms responsible for the conversion of the preleukemic clone, carrying the inherited mutations of PAX5, into pB-ALL are not understood yet. However, recent results suggest that the B cell-specific enzyme AID is supposed to be the predominant driver of clonal evolution in human ETV6-RUNX1 pB-ALL [5, 6] and B-cell lymphoma [7]. The pB-ALL in our mouse model originated as a result of delayed infection exposure. It offers a unique possibility to confirm if the proposed AID-mechanisms are involved in the conversion of the preleukemic clone into a full-blown leukemia. \n \nOther major question that arise in light of these findings are if the timing and pattern of infectious exposure is indeed relevant for pB-ALL development, how the second hit impacts on the target cell, and what are the qualitative and\/or quantitative figures that make Pax5+\/\u2212 stem\/progenitor target cells more vulnerable to malignancy. At the end, it will broaden our horizon and help us to change the way we approach childhood leukemia, from diagnosis and treatment to prevention first.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2775012,"openaccessinfo":{"externalids":{"MAG":"2323854600","ACL":null,"DOI":"10.18632\/AGING.100815","PubMedCentral":"4600617","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Enhanced oil recovery methods are tested and optimized in synthetic \nmedia, emulating porosity and permeability of real oil-bearing rocks. \nSuch a medium was produced with sintered bi-disperse glass beads and \nmicroCT images (4 \u00b5m resolution) were acquired at different stages of \nfluid motion through the medium. Synthetic seawater with or without oil\/ \nwater emulsion was used to recover oil previously saturating the medium\u00b4s \npores. The water was doped with KI to fine tune X-ray absorption. Thus, \n3D images showing the beads, doped water and residual oil presented \na 3-modal histogram. After denoising with a non-local means filter, the \nimages were segmented and the distribution of residual oil ganglia was \nvisualized and quantified. Probability density functions of volumes (~10^4 \nganglia spanning 8 orders of magnitude) show well defined exponential \nbehaviors for the displacement of oil by water, while the use of emulsions \nprovides better recovery efficiency with larger numbers of larger ganglia","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":201298977,"openaccessinfo":{"externalids":{"MAG":"2965988845","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Solution-cast membranes from sulfonated polyimide (SPI) and its blend were prepared from polyethersulfone (PES) and SPI. The water uptake and swelling were tested and compared between the SPI membrane and the four kinds of blend membranes. Through comparison of the stability of the membranes, we concluded that the PES could greatly increase the stability of the whole membrane and restrict the swelling. However, the PES did not decrease the water uptake very much. We also compared the fuel cell performance with different membranes. The performance was decreased when the content of the PES in the blend membrane increased. The loss of the fuel cell performance with the blend membranes did not decrease very much before the content of the PES was exceeded 20%. It was prospected that the blend membrane could increase the stability of the SPI and, more importantly, even replace the commercial Nafion membranes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":725688,"openaccessinfo":{"externalids":{"MAG":"2501084056","ACL":null,"DOI":"10.1021\/jp710704v","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The two formations and eight members that constitute the Upper Cambrian in the Llano uplift of central Texas are described or redefined, and their lithic characters in 19 measured sections are graphically summarized. Standard reference to them is thus furnished.\n\nThe Riley formation comprises the basal Paleozoic strata of the Llano uplift. Its initial sediments were deposited on a submerged pre-Cambrian terrane having a known topographic relief as great as 800 feet. Its thickness normally averages about 680 feet but ranges from probably less than 200 to about 800 feet. At most places it is subequally divisible between the Hickory sandstone member below and the Cap Mountain limestone member above, with the thin but widespread, glauconitic Lion Mountain sandstone member capping and completing the sequence.\n\nThe Wilberns formation includes five named members between the Riley formation and rocks of the Lower Ordovician Ellenburger group. It normally averages about 580 feet thick and ranges from 540 to 610 feet thick, but in the southeastern corner of the Llano uplift truncation of the upper beds has reduced it to 360 feet. The thin but widespread, nonglauconitic Welge sandstone member introduces the sequence. Above it is the Morgan Creek limestone member, grading to the succeeding argillaceous beds of the Point Peak shale. At the top of the sequence are the San Saba limestone and Pedernales dolomite members. These two are essentially equivalent and gradational facies, with the Pedernales normally overlying the San Saba.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":131480419,"openaccessinfo":{"externalids":{"MAG":"2163907775","ACL":null,"DOI":"10.1130\/0016-7606(1947)58[109:SOTUCL]2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gender differences play a major role in the manifestation of cardiovascular disease including cardiac arrhythmias. In particular, female sex is an independent risk factor for development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes but also in acquired long QT syndromes which occur as adverse effects of existing drugs. Recent clinical and experimental studies suggest that the gender differences may stem, at least in part, from gender differences in cardiac repolarization process, that is longer rate-corrected QT (QT(C)) interval in women than in men. In women, QT(C) interval and arrhythmic risks in TdP alter cyclically during menstrual cycle, suggesting a critical role of female sex hormones in cardiac repolarization process. These gender differences in fundamental cardiac electrophysiology result from variable ion channel expression and diverse sex hormonal regulation via long term genomic and acute non-genomic pathways, and sex differences in drug responses and metabolisms. In particular, non-genomic actions of testosterone and progesterone on cardiac ion channels likely to contribute to the gender differences in cardiac repolarization processes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4675192,"openaccessinfo":{"externalids":{"MAG":"1988318884","ACL":null,"DOI":"10.1248\/BPB.B212021","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Symptoms and signs that point to immunodeficiency are numerous and various. Recurrent history, unusual pathogens or severe course of infections should alert any physician to potential immunodeficiency state. If infections are the hallmark of immunodeficiency, other manifestations such as autoimmune diseases or particular malignancies can be a presenting feature of immunodeficiency. If many primary or secondary immunodeficiencies are well defined, it is important for the general practitioners to know that a large number of underlying conditions can lead to immunodeficiency states.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43840081,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sustained proliferative signaling and resisting cell death are two fundamental hallmarks of cancer. The AKT pathway is a frequently aberrant, highly interconnected, intracellular signaling network that connects a wide variety of cell stimuli to proliferative and apoptotic cellular control. We have shown that inappropriate control of the AKT pathway underlies failure of chemotherapy in ovarian cancer and furthermore have shown that DNA-PKcs, a component of the non-homologous-end-joining DNA repair pathway, phosphorylates AKT on serine residue 473 in the nucleus of platinum resistant ovarian tumor cells, but not sensitive cells from the same patient. DNA-PK mediated AKT activation in chemoresistant cells results in inhibitory phosphorylation of the pro-apoptotic protein BAD and stabilization of the anti-apoptotic Bcl-2 protein. We report that inhibition of DNA-PK restores response to cisplatin in chemoresistant ovarian cancer cells in vivo. SKOV3 tumor xenografts were implanted subcutaneously into the flanks of Balb\/c nu\/nu mice and treated with 7.5mg\/kg or 10mg\/kg DNA-PKcs inhibitor, NU7441 daily (5days on\/2 days off) for 2 weeks alone or in combination with 1mg\/kg cisplatin twice weekly. DNA-PK inhibition or cisplatin alone were ineffective however in combination decreased tumor growth at 14 days by 89% (7.5mg\/kg NU7441) and 90% (10mg\/kg NU7441), relative to platinum only treatment. Tumor xenografts were recovered and analyzed by reverse phase protein array (RPPA). Analysis has revealed AKT pathway signaling alterations that underlie the enhanced response to cisplatin on addition of NU7441. DNA-PK inhibition is an attractive therapeutic strategy for resensitizing resistant tumors to platinum based therapy, directly linking the DNA damage caused by platinum to the pro-survival AKT pathway. This abstract is also presented as Poster A50. Citation Format: Azadeh Cheraghchi-Bashi-Astaneh, Camila H. De Sousa, Elaina Maginn, Yan Dai, Harpreet Wasan, Gordon B. Mills, Hani Gabra, Euan A. Stronach. DNA-PK inhibition resensitizes ovarian cancer cells to cisplatin in vivo and is associated with modulation of AKT pathway signaling. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr PR04.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":71534757,"openaccessinfo":{"externalids":{"MAG":"1995228865","ACL":null,"DOI":"10.1158\/1078-0432.OVCA13-PR04","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Economic informality is often treated as defining a segregated, leeching, anti-systemic and apolitical sphere of an economic system. While an estimate 2.8 times the combined total populations of Canada and the United States comprise the informal labour population of India, the visibility of the workers involved is largely obstructed by a combination of natural and forced anonymity. Political unionism is shown as an imperfect instrument to respond to the varied interests of union members in addition to falling under criticism as a privileged process for an elitist, minority section of the working class in India. One of two labour unions recognized as clearly outside political associations is the Self Employed Women's Association (SEWA), through which the voice, struggle and intense productivity of workers dubbed part of the informal economic sphere has been brought to the attention of domestic and international policy initiatives. In an analysis of studies engaging with the organized bidi workers of Gujarat and the history of political unionism in India, we see that the barrier between formal and informal is quite firmly an inaccurate product of our analysis. While individual agency in India should be supported and targeted for improvement by international labour laws, conventions and organizations, there needs to be a realization that protection from exploitation is necessary yet blind incorporation of the informal into the formal is not the logical conclusion for sustainable development practices.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":156675123,"openaccessinfo":{"externalids":{"MAG":"2369362803","ACL":null,"DOI":"10.14288\/1.0071735","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Streptococcus pneumoniae, a penicillin-sensitive bacterium, is recognized as a major cause of pneumonia and is treated clinically with penicillin-based antibiotics. The rapid increase in resistance to penicillin and other antibiotics affects 450 million people globally and results in 4 million deaths every year. To unveil the mechanism of resistance of S. pneumoniae is thus an important issue to treat streptococcal disease that might consequently save millions of lives around the world. In this work, we isolated a streptococci-conserved L-ascorbate 6-phosphate lactonase, from S. pneumoniae ATCC 49136. This protein reveals a metallo-\u03b2-lactamase activity in vitro, which is able to deactivate an ampicillin-based antibiotic by hydrolyzing the amide bond of the \u03b2-lactam ring. The Michaelis parameter (Km) = 25 \u03bcM and turnover number (kcat) = 2 s-1 were obtained when nitrocefin was utilized as an optically measurable substrate. Through confocal images and western blot analyses with a specific antibody, the indigenous protein was recognized in S. pneumoniae ATCC 49136. The protein-overexpressed S. pneumonia exhibits a high ampicillin-tolerance ability in vivo. In contrast, the protein-knockout S. pneumonia reveals the ampicillin-sensitive feature relative to the wild type strain. Based on these results, we propose that this protein is a membrane-associated metallo-\u03b2-lactamase (MBL) involved in the antibiotic-resistant property of S. pneumoniae.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25635595,"openaccessinfo":{"externalids":{"MAG":"2406700388","ACL":null,"DOI":"10.1371\/journal.pone.0155905","PubMedCentral":"4877090","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0155905&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Stroke is one of the leading causes of death and disability and it is more likely to occur in those who are older. Because people are living longer, the definition of \"old\" continues to evolve. Age alone should not influence the healthcare that a patient receives, however, evidence indicates that this does occur, especially in older patients. On the basis of the available evidence, it is time to reconsider whether or not stroke care should differ in older survivors of stroke and if so, why. This is a narrative review of stroke-related health care in those with a recent ischemic stroke. It seeks to answer the following question: Should patients aged \u226580 years who have experienced a recent ischemic stroke receive standard care or something different, and if they should receive something different, what should they receive and why? The review focusses on long-term survival, hyper-acute care, secondary prevention, and rehabilitation. The authors propose a number of recommendations in relation to stroke care in older survivors of a recent ischemic stroke.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29169840,"openaccessinfo":{"externalids":{"MAG":"2706222414","ACL":null,"DOI":"10.3390\/geriatrics2020018","PubMedCentral":"6371093","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2308-3417\/2\/2\/18\/pdf?version=1497871021","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Mycobacterium tuberculosis is known to express a low-molecular weight protein tyrosine phosphatase. This enzyme, denoted as MptpA (Mycobacterium protein tyrosine phosphatase A), is essential for the pathogen to escape the host immune system and therefore represents a target for the search of antituberculosis drugs. MptpA was shown to undergo a conformational transition during catalysis, leading to the closure of the active site, which is by this means poised to the chemical step of dephosphorylation. Here we show that MptpA is subjected to substrate activation, triggered by p-nitrophenyl phosphate or by phosphotyrosine. Moreover, we show that the enzyme is also activated by phosphoserine, with serine being ineffective in enhancing MptpA activity. In addition, we performed assays under pre-steady-state conditions, and we show here that substrate activation is kinetically coupled to the closure of the active site. Surprisingly, when phosphotyrosine was used as a substrate, MptpA did not obey Michealis\u2013Menten kinetics, but we observed a sigmoidal dependence of the reaction velocity on substrate concentration, suggesting the presence of an allosteric activating site in MptpA. This site could represent a promising target for the screening of MptpA inhibitors exerting their action independently of the binding to the enzyme active site.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212622919,"openaccessinfo":{"externalids":{"MAG":"3010383598","ACL":null,"DOI":"10.1021\/acs.biochem.0c00059","PubMedCentral":"7997110","ArXiv":null},"license":"CCBY","url":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.biochem.0c00059","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A one-pot C2-amidoglycosylation reaction for the synthesis of 2-N-acyl-2-deoxy-beta-pyranosides from glycals is described. Glycal donors activated by the reagent combination of thianthrene-5-oxide (11) and Tf2O, followed by treatment with an amide nucleophile and a glycosyl acceptor, lead to the formation of various C2-amidoglycoconjugates. Both the C2-nitrogen transfer and the glycosidic bond formation proceed stereoselectively, allowing for the introduction of both natural and nonnatural amide functionalities at C2 with concomitant anomeric bond formation in a one-pot procedure. Tracking of the reaction by low-temperature NMR spectroscopy employing 15N- and 18O-isotope labels suggests a mechanism involving the formation of the C2-sulfonium glycosyl imidate 39 as well as oxazoline 37 as key intermediates in this novel oxidative glycosylation process.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6307729,"openaccessinfo":{"externalids":{"MAG":"2034889166","ACL":null,"DOI":"10.1021\/JA026281N","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using a proximal duodenal loop in conscious rats, we investigated interactions between prostaglandin E2 and nicotinic and muscarinic receptor mechanisms previously found to be involved in the duodenal HCO3- response to HCl. In previous studies using the same model, a 5-min perfusion of the duodenal loop with 150 mmol l-1 HCl produced a marked and sustained HCO3- response. In the present study, the identical challenge produced a rapid 20-fold increase in the luminal output of prostaglandin E2 during acid exposure, followed by a sustained more than twofold elevation above the basal level during the 45 min monitored. The prostaglandin synthesis inhibitor indomethacin (4 mg kg-1 i.p.) suppressed the output of prostaglandin E2 during the HCl challenge from 131 +\/- 84 to 15.4 +\/- 10.0 pmol cm-1 h-1, and in the post-stimulatory period from 17.3 +\/- 9.1 to 4.4 +\/- 2.2 pmol cm-1 h-1. The nicotinic receptor antagonist hexamethonium (20 mg kg-1 i.v.) had no effect on the output of prostaglandin E2. The muscarinic receptor antagonist atropine (0.5 mg kg-1 s.c.) had no effect on the output of prostaglandin E2 during HCl challenge, but reduced the post-stimulatory output to 7.7 +\/- 4.1 pmol cm-1 h-1. Perfusion of the duodenal loop with 0.1 mmol l-1 prostaglandin E2 produced a HCO3- response that was abolished by hexamethonium (20 mg kg-1 i.v.), but not affected by atropine (0.5 mg kg-1 s.c.).(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23711038,"openaccessinfo":{"externalids":{"MAG":"2078093479","ACL":null,"DOI":"10.1111\/J.1748-1716.1990.TB08950.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Three cracks assumed to be caused by Stress Corrosion Cracking (SCC) were detected on shroud support of Tokai Daini Nuclear Power Plant (Tokai-2) in 2005. Additional inspections were performed in 2009 and 2011, and additional initiation and propagation of cracks were observed on core shroud and shroud support. Flaw evaluation was performed at each time. The results showed that these structures were allowed to use without repair.There has been a few inspection experiences in Japan, of successive SCC behavior in operating plants. In this paper, the change of crack shape and crack growth rate (CGR) was investigated. The result showed that cracks tend to change its shape as they grow and crack growth rate in an operating plant was below the crack growth disposition line of Japan Society of Mechanical Engineers (JSME) Code.Water Jet Peening for core shroud with cracks was performed in 2011 and Noble Metal Chemical Addition is planned in next cycle to mitigate crack initiation and growth. These preventive maintenances are effective also in cracked surface. It is important to confirm that crack behavior and effect of preventive maintenances in successive inspections.Copyright \u00a9 2013 by ASME","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":111319444,"openaccessinfo":{"externalids":{"MAG":"2044172599","ACL":null,"DOI":"10.1115\/PVP2013-97257","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Widespread overuse of antibiotics has led to the emergence of numerous antibiotic-resistant bacteria; among these are antibiotic-subsisting strains capable of surviving in environments with antibiotics as the sole carbon source. This unparalleled expansion of antibiotic resistance reveals the potent and diversified resistance abilities of certain bacterial strains. Moreover, these strains often possess hypermutator phenotypes and virulence transmissibility competent for genomic and proteomic propagation and pathogenicity. Pragmatic and prospicient approaches will be necessary to develop efficient therapeutic methods against such bacteria and to understand the extent of their genomic adaptability. This review aims to reveal the niches of these antibiotic-catabolizing microbes and assesses the underlying factors linking natural microbial antibiotic production, multidrug resistance, and antibiotic-subsistence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44699241,"openaccessinfo":{"externalids":{"MAG":"2044998678","ACL":null,"DOI":"10.3109\/1040841X.2013.875982","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : This documentation describes, the development of the RTM and it tangent linear and adjoint models for the use of new Goestationary Operational Environmental Satellite (GOES) system, Defense Meteorology Satellite Program (DMSP) Special Sensor Microwave Temperature sounder SSM\/T, the Special Sensor Microwave Water Vapor Profiler SSM\/T-2. The RTM is the major forward (observation) operator which calculates the radiance based on the model state and the input of the satellite geometry. The tangent linear and adjoint of the forward observation operator is developed according to the method described by Navon et al. (1992) and is also described in this documentation. Satellites are a critical part of the global observing system, particularly over oceans where very few other observations exist. While temperature and humidity retrievals from satellite observations have played some roles in numerical weather prediction, more benefits may be obtained by the direct use of the rawer form of data, which could be handled with the introduction of adjoint techniques into meteorology (Le Dimet and Talagrand, 1986). This document is organized as follows: A brief description of GOES-8, SSM\/T and SSM\/T2 Satellites is provided in Section 2. The RTMs are presented in Section 3. Section 4 reports the development of the tangent linear and adjoint of RTMs and the correctness test results. The linkage of the RTM and the RTM adjoint operator is given in Section 5. The last section, Section 6, provides a description of the source codes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":126612099,"openaccessinfo":{"externalids":{"MAG":"231906732","ACL":null,"DOI":"10.21236\/ada370827","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.dtic.mil\/dtic\/tr\/fulltext\/u2\/a370827.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Behavioral phylogeny, via comparative studies, has been successfully used to hypothesize when a behavior appeared and to identify the selective pressures at its origin. The application of behavioral phylogeny to social learning is very promising, but proponents of the approach must also address several obstacles before measurably advancing the field of study. The aim of this review is to highlight and to propose solutions for these challenges. First, the term \"social learning\" includes a diversity of non-exclusive mechanisms from simple enhancement to complex imitation which can be based on different cognitive process. So, a phylogenetic approach of social learning cannot be a unitary one and should be expressed in terms of biases and choices among the varied range of possible mechanisms. However, to ensure comparison of homologous mechanisms in the species of interest, it is necessary to first properly identify mechanisms as well as to identify their underlying structure, their limitations and their adaptive flexibility. Second, any experiment aiming to identify the social learning mechanisms employed by a species should take into account possible \"contextual variables\" and, consequently, any resulting content and context biases. With respect to content biases, social learning may selectively involve stimuli characteristics when, for example, foraging and distinguishing non-toxic foods, manufacturing and using tools, choosing songs and other behaviors to court a mate, discovering migration paths and recognizing predators. Context biases are dependent on the context in which stimuli occur and are thus reflected by diverse social learning strategies, such as \"when and who to copy\". Third, it is important to emphasize that content and context biases can strongly depend on the age, sex, social rank, personality traits and previous experiences (including parental, epigenetic, ecological and cultural effects) of the tested individuals. These factors influence the mechanisms concerned. For example, while a very social individual may learn through imitation because of closer proximity to the demonstrator, a more timid or a lower-ranking individual can become as socially aware of and motivated to experience the same contingencies through respective local or stimulus enhancements. Individuals might even specialize in idiosyncratic learning mechanisms depending on the possible costs of switching strategies. Therefore, in considering social learning mechanisms that are nurtured and shaped by experiences during development, only a holistic approach taking into account content and context biases, as well as physical and psychological characteristics of the individuals tested, will correctly assess social learning capacities and the evolution of those capacities within species.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":147875661,"openaccessinfo":{"externalids":{"MAG":"2409194053","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The TRC code, a mid-course tracking code for ballistic missiles, has previously been implemented on a 1024-processor MIMD (Multiple Instruction Multiple Data) massively parallel computer. Measures of Effectiveness (MOE) for this algorithm have been developed for this computing environment. The MOE code is run in parallel with the TRC code. Particularly useful MOEs include the number of missed objects (real objects for which the TRC algorithm did not construct a track); of ghost tracks (tracks not corresponding to a real object); of redundant tracks (multiple tracks corresponding to a single real object); and of unresolved objects (multiple objects corresponding to a single track). All of these are expressed as a function of time, and tend to maximize during the time in which real objects are spawned (multiple reentry vehicles per post-boost vehicle). As well, it is possible to measure the track-truth separation as a funGtion of time. A set of calculations is presented illustrating these MOEs as a function of time for a case with 99 postboost vehicles, each of which spawns 9 reentry vehicles.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38410575,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mycoplasma hyopneumoniae (Mhp) is the etiologic agent of mycoplasma pneumonia in swine. The purpose of this study was to develop a species-specific polymerase chain reaction (PCR)-based diagnostic reagent for the identification of Mhp. Based upon DNA sequence analysis of a cloned fragment of Mhp DNA, PCR primers were constructed and tested against different strains of Mhp, Mycoplasma flocculare, other mycoplasma species, and non-Mollicute micro-organisms which commonly inhabit the respiratory tracts of swine. A total of 40 field isolates from Mhp and four field isolates of M. flocculare have been examined. Positive signals were obtained in PCR with Mhp reference strains and all 40 Mhp field isolates, but not with other Mollicutes micro-organisms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26378265,"openaccessinfo":{"externalids":{"MAG":"2055305319","ACL":null,"DOI":"10.1006\/MCPR.1993.1056","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The establishment of the Australasian Society of Cardiac and Thoracic Surgeons (ASCTS) at the beginning of the 1990s gave rise to an early proposal for the development of a cardiac surgical database. The Victorian Government gave its in-principle backing to a statewide database project from late 1997. Release of a promised dollar 200,000 grant for development was contingent on the ASCTS being able to fulfil several initial requirements. These were: (i) the provision of an indicative annual report outlining performance against a series of clinical indicators; (ii) an indicative peer-review process; and (iii) the addressing of issues surrounding intellectual property and ownership of any database that was developed. In outlining a strategy to be used in developing and implementing the project plan, it was determined by the project development team that all Victorian cardiac surgical units were, in fact, collecting similar data, but were using different software and analytical tools. The Cardiovascular Disease Prevention Unit at the Baker Medical Research Institute in Melbourne has developed a model of mortality and risk-adjusted complications out of the pooled Victorian data. This, it is hoped, will be a forerunner of a major achievement in the monitoring of cardiac surgery procedures nationally, and the attainment of national and international best practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12957740,"openaccessinfo":{"externalids":{"MAG":"2169497103","ACL":null,"DOI":"10.1046\/J.1444-2892.2001.00072.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper deals with the variability of short term creep rupture time based on previous creep rupture tests and the statistical methodology of the creep life prediction. The results of creep tests performed using constant uniaxial stresses at 600, 650, and 700\u2103 elevated temperatures were used for a statistical analysis of the inter-specimen variability of the short tenn creep rupture time. Even under carefully controlled identical testing conditions, the observed short-term creep rupture time showed obvious inter-specimen variability. The statistical aspect of the short term creep rupture time was analyzed using a Weibull statistical analysis. The effect of creep stress on the variability of the creep rupture time was decreased with an increase in the stress level. The effect of the temperature on the variability also decreased with increasing temperature. A long term creep life prediction method that considers this statistical variability is presented. The presented method is in good agreement with the Lason-Miller Parameter (IMP) life prediction method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137642531,"openaccessinfo":{"externalids":{"MAG":"1961010449","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A clinical isolate of Proteus mirabilis Lil-1 was obtained from a Vietnamese patient hospitalized in Paris, France. This isolate was resistant to cephalosporins, and there was marked synergy between cephalosporins and clavulanic acid together with unusual synergy between cefoxitin and cefuroxime. PCR analysis revealed the presence of blaVEB-1, an integron-located gene coding for an extended-spectrum beta-lactamase (ESBL) identified previously in an Escherichia coli isolate MG-1 from Vietnam. Using class 1 integron primers and blaVEB-1 intragenic primers, the insert region of the blaVEB-1-containing integron along with flanking sequences were amplified from P. mirabilis Lil-1 whole-cell DNA. A novel class 1 integron, In55, was identified that contained, in addition to intI1, qacEDelta1, sul1 and Orf5 genes, an 8 kb variable region. This region was comparable in size to that found previously in E. coli MG-1, but different from those previously identified in two Pseudomonas aeruginosa isolates from Thailand. In55 was located on a 190 kb self-transferable plasmid, which was different in size and structure from that found in E. coli MG-1. The finding of blaVEB-1 on different plasmids and integrons in enterobacterial isolates underlines the interspecies spread of this novel ESBL gene.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38493448,"openaccessinfo":{"externalids":{"MAG":"2132857238","ACL":null,"DOI":"10.1093\/JAC\/46.5.703","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many local Indonesian assets have not been protected by Geographical Indications and very vulnerable to being exploited by irresponsible parties, one of which is cybersquatting crime by registering a website address on the internet using the name of a geographically indicated product without the right as the legal owner then selling the domain name for expensive price causing losses for local Indonesian assets that have not been registered with Geographical Indications. The problem of this research: How is the legal protection on local assets that have not yet registered as Geogragraphical Indication from cybersquatting crime. The purpose of this research is to find out the legal protection of unregistered local asset as geographical indication product from cybersquatting. The legal research method used is the normative legal research method using the statutory approach and the conceptual approach. The result of the research is the protection of local assets from cybersquatting crimes that have not been protected by Geographical Indications is protected under Article 23 of the ITE Law and for every person whose rights are violated due to cybersquatting crimes, they have the right to file a lawsuit to cancel the unauthorized use of domain names by other parties.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":236869664,"openaccessinfo":{"externalids":{"MAG":"3168721332","ACL":null,"DOI":"10.24843\/AC.2020.V05.I03.P06","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"[Extract] The Port Curtis Western Basin Dredging and Disposal Project (WBDDP) was identified as posing a high level of environmental risk to marine habitats in the Gladstone area, particularly to seagrass meadows. The process of marine dredging elevates suspended solids within the water column, reducing light availability to marine habitats, and can result in high levels of stress and mortality to benthic primary producers such as seagrasses (Erftemeijer et al. 2006). Minimum light requirements (MLR) for seagrass differ among species and seasons, yet it is well established that changes in the availability of light remains the primary factor affecting seagrass distribution, abundance and productivity (Duarte et al. 1997; Vermaat et al. 1997; Hemminga & Duarte 2000; Erftemeijer et al. 2006; Ralph et al. 2007). \nSince 2009, James Cook University (JCU and previously the Department of Agriculture, Fisheries and Forestry, DAFF) and the University of Technology Sydney (UTS) have been actively undertaking seagrass research to assess seagrass health during the WBDDP. The primary aim of this research has been to address one of the Queensland Coordinator General's conditions on the project to develop a water quality monitoring program incorporating a) minimum light requirements of local seagrasses and b) the use of sub- lethal indicators of seagrass light stress to assess seagrass condition should seagrass light requirement triggers be exceeded. \nIn May 2012, DAFF (now JCU) delivered a report that documented a light-based management approach to protect Gladstone seagrasses from dredging impacts associated with the WBDDP. Through a multifaceted research program spanning over two years, Chartrand et al. (2012) determined that Z. muelleri the dominant species in Gladstone harbour requires between 4.5 and 12 mol quanta m 2 d 1 during the growing season over a minimum period of two weeks to survive. Trends in benthic irradiance and seagrass condition at permanent survey sites showed that, in general Z. muelleri consistently received greater than 6 mol m 2 d 1 over a two week rolling average at most locations in the harbour during the growing season (when seagrass remained stable or increased in abundance). This value was therefore trialled as a trigger for management actions as part of an adaptive light based approach to manage potential impacts on seagrasses during Western Basin developments. \nWhile we have empirically established that 6 moles of irradiance per day is required to maintain a seagrass meadow in Gladstone Harbour, we do not have the ability to accurately predict over what period of time this quantity of light energy is required. While photophysiological and stable isotope (13C\/15N) studies showed promising results for detecting changes in the seagrass health when exposed to dredging events (Chartrand et al. 2012), these methods lacked the temporal resolution to function as a sub-lethal stress indicator. The current focus of research is on a genetic approach which looks at changes in expression level of genes that respond when light limitations cause a change in the overall health of the plant. \nThe specific aim of this research is to develop a fast and accurate RT-qPCR-based seagrass health monitoring system to provide a sub-lethal indicator for stress linked to managing dredging impacts. This new biomarker can be assessed when light falls below the required value in a light-based approach to dredge management. Such a biomarker will allow for robust and defendable decisions to be made on the health of seagrass potentially impacted by dredging before mortality symptoms become apparent. This interim report outlines progress on the project to date. The report is divided into two sections to describe progress on a) the laboratory development program and b) the field\/laboratory validation program.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":133692582,"openaccessinfo":{"externalids":{"MAG":"2615567929","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aims The aim was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of octreotide subcutaneous (s.c.) depot, a novel octreotide formulation. Methods This was a phase I, randomized, open label study. After a single dose of octreotide immediate release (IR) 200 \u00b5g, subjects were randomized to one of eight groups to receive three monthly injections of octreotide s.c. depot A 10, 20 or 30 mg, B 30 mg, C 10, 20 or 30 mg or long acting octreotide (octreotide LAR) 30 mg. Results One hundred and twenty-two subjects were randomized. For all depot variants, onset of octreotide release was rapid and sustained for up to 4 weeks. The relative octreotide bioavailability of depot variants vs. octreotide IR ranged from 0.68 (90% confidence interval [CI] 0.61, 0.76) to 0.91 (90% CI 0.81, 1.02) and, vs. octreotide LAR, was approximately four- to five-fold greater: 3.97 (90% CI 3.35, 4.71) to 5.27 ng ml\u20131 h (90% CI 4.43, 6.27). All depot variants showed relatively rapid initial reductions of insulin-like growth factor 1 (IGF-1) compared with octreotide LAR. A trend of octreotide dose dependence was also indicated from the plasma concentrations and suppression of IGF-1. Maximum inhibition of IGF-1 at steady-state was highest for depot B and C. All depot treatments were well tolerated. The most frequent adverse events were gastrointestinal related. Conclusions Octreotide s.c. depot provides greater octreotide bioavailability with a more rapid onset and stronger suppression of IGF-1 than octreotide LAR in healthy volunteers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11687293,"openaccessinfo":{"externalids":{"MAG":"2116611239","ACL":null,"DOI":"10.1111\/bcp.12698","PubMedCentral":"4574831","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/bcp.12698","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"We answer a question of Aharoni by showing that every separable metric space can be Lipschitz 2-embedded into $c_0$ and this result is sharp; this improves earlier estimates of Aharoni, Assouad and Pelant. We use our methods to examine the best constant for Lipschitz embeddings of the classical $\\ell_p-$spaces into $c_0$ and give other applications. We prove that if a Banach space embeds almost isometrically into $c_0$, then it embeds linearly almost isometrically into $c_0$. We also study Lipschitz embeddings into $c_0^+$.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16472537,"openaccessinfo":{"externalids":{"MAG":"2951046662","ACL":null,"DOI":"10.4064\/FM199-3-4","PubMedCentral":null,"ArXiv":"0708.3924"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Supersymmetry of the Wess\u2013Zumino (N = 1, D = 4) multiplet allows field equations that determine a larger class of geometries than the familiar Kahler manifolds, in which covariantly holomorphic vectors rather than a scalar superpotential determine the forces. Indeed, relaxing the requirement that the field equations be derivable from an action leads to complex flat geometry. The Batalin\u2013Vilkovisky formalism is used to show that if one requires that the field equations be derivable from an action, we once again recover the restriction to Kahler geometry, with forces derived from a scalar superpotential.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15377404,"openaccessinfo":{"externalids":{"MAG":"2054404946","ACL":null,"DOI":"10.1088\/0264-9381\/20\/23\/014","PubMedCentral":null,"ArXiv":"hep-th\/0306244"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/hep-th\/0306244","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Corresponding author: email@example.com DOI: 10.21608\/jtcps.2019.9928.1019 \u00a92019 National Information and Documentation Centre (NIDOC) IN A MILLENNIAL world we need new manufacturing technologies if we are to meet the demands of a new generation of consumers. Microwave technologies facilitate that evaluation, let's investigate how microwave technology is disrupting every sector of textile coloration. The purpose of this review is to evaluate the current status of microwave processing technology, and to find out applications of unique properties leading to replacement of conventional techniques due to reduced cost, energy, and time, and enhance the properties of the different fabric for end use. Furthermore, we will focus on the future of textile coloration and developments employing the microwave processing. 3","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":199414956,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A new algorithm, referred to as the SPAR (Semiparametric) algorithm, is presented herein for target feature extraction and complex image formation via synthetic aperture radar (SAR). The algorithm is based on a flexible data model that models each target scatterer as a two-dimensional (2-D) complex sinusoid with arbitrary unknown amplitude and constant phase in cross-range and with constant amplitude and phase in range. By attempting to deal with one corner reflector, such as one dihedral or trihedral, at a time, the algorithm can be used to effectively mitigate the artifacts in the SAR images due to the flexible data model. Another advantage of SPAR is that it can be used to obtain initial conditions needed by other parametric target feature extraction methods to reduce the total amount of computations needed. Both numerical and experimental examples are provided to demonstrate the performance of the proposed algorithm.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1,"unknown":3}},"corpusid":109663347,"openaccessinfo":{"externalids":{"MAG":"1989133640","ACL":null,"DOI":"10.1109\/7.805448","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/doi.org\/10.1109\/7.805448","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Theoretical perspectives of cognitive development have maintained that functional integration of the prefrontal cortex across infancy underlies the emergence of attentional control and higher cognitive abilities in early childhood. To investigate these proposed relations, we tested whether functional integration of prefrontal regions across the second half of the first year predicted observed cognitive performance in early childhood 1 year prior indirectly through observed attentional control (N = 300). Results indicated that greater change in left-but not right-frontal EEG coherence between 5 and 10 months was positively associated with attentional control, cognitive flexibility, receptive language, and behavioral inhibitory control. Specifically, a larger increase in coherence between left frontal regions was positively associated with accuracy on a visual search task at Age 2, and visual search accuracy was positively associated with receptive vocabulary, performance on a set-shifting task (DCCS), and delay of gratification at Age 3. Finally, the indirect effects from the change in left frontal EEG coherence to 3-year cognitive flexibility, receptive language, and behavioral inhibitory control were significant, suggesting that internally controlled attention is a mechanism through which early neural maturation influences children's cognitive development. (PsycINFO Database Record","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":22849763,"openaccessinfo":{"externalids":{"MAG":"2506335497","ACL":null,"DOI":"10.1037\/dev0000149","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/doi.org\/10.1037\/dev0000149","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"P-glycoprotein (P-gp) is encoded by the multidrug resistance (MDR1) gene and is well studied as a multi-drug resistance transporter. Peritoneal adhesion formation following abdominal surgery remains an important clinical problem. Here, we found that P-gp was highly expressed in human adhesion fibroblasts and promoted peritoneal adhesion formation in a rodent model. Knockdown of P-gp expression by intraperitoneal injection of MDR1-targeted siRNA significantly reduced both the peritoneal adhesion development rate and adhesion grades. Additionally, we found that operative injury up-regulated P-gp expression in peritoneal fibroblasts through the TGF-\u03b21\/Smad signaling pathway and histone H3 acetylation. The overexpression of P-gp accelerated migration and proliferation of fibroblasts via volume-activated Cl- current and cell volume regulation by enhancing phosphorylation of the chloride channel-3. Therefore, P-gp plays a critical role in postoperative peritoneal adhesion formation and may be a valuable therapeutic target for preventing the formation of peritoneal adhesions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15125401,"openaccessinfo":{"externalids":{"MAG":"2416031218","ACL":null,"DOI":"10.7150\/thno.13907","PubMedCentral":"4729769","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.7150\/thno.13907","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background Yolk sac tumor is a type of germ cell tumor. It commonly arises in the gonads but sometimes can occur outside the gonads. Primary intracranial yolk sac tumors were very rare. It is always located in the pineal, suprasellar and posterior third ventricular region. The incidence of yolk sac tumor is estimated as less than 8% of all primary intracranial germ cell tumors. Multifocal primary intracranial yolk sac tumors have seldom been reported. Case Description Here we reported a 29 years old male patient with a sudden coma and a history of headaches for one month. Computed Tomography and magnetic resonance imaging of the head showed three masses located at the suprasellar region, pineal region and left temporal lobe separately. The mass at the left temporal lobe was successfully resected with emergency surgery, and decompressive craniectomy was also performed. Intraoperative findings revealed that the tumor was a solid mass with intra-tumoral haemorrhage. The pathology examination confirmed the diagnosis of yolk sac tumor. Hematoxylin and eosin staining clearly showed the Schiller-Duval body. Whole-brain radiotherapy was performed after the operation, and the patient died in a local hospital 11 months after the surgery. Conclusions We reported a case of multifocal primary intracranial yolk sac tumor in an adult patient. Then we reviewed the literature and discussed the treatment and diagnosis of patients with primary intracranial yolk sac tumors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247868466,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21037\/tcr-21-2561","PubMedCentral":"9189240","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/tcr.amegroups.com\/article\/viewFile\/62808\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"An interpersonal relation have a high risk for causing a heartbreak within every person involved. Forgiving is one of the key of heartbreak remedies. However, it requires a great inside power to be able to forgive the others, that power would be even greater with the social support. This research aims to find relationship between social support towards forgiving behavior of college students. There are 420 college students involved as the sample of this quantitative research. Data retrieval uses a forgive behavior scale and a social support scale. Analysis correlation test prove that there is a relation between the social supports and student's forgiving behavior.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":240662850,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4324\/9780429274855-17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Single-molecule and cryo-EM studies reveal molecular acrobatics of signal recognition particle that initiates protein translocation. The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here, structural, biochemical, and single-molecule studies show that this transition requires multiple sequential conformational rearrangements in the targeting complex initiated by guanosine triphosphatase (GTPase)\u2013driven compaction of the SRP receptor (SR). Disruption of these rearrangements, particularly in mutant SRP54G226E linked to severe congenital neutropenia, uncouples the SRP\/SR GTPase cycle from protein translocation. Structures of targeting intermediates reveal the molecular basis of early SRP-SR recognition and emphasize the role of eukaryote-specific elements in regulating targeting. Our results provide a molecular model for the structural and functional transitions of SRP throughout the targeting cycle and show that these transitions provide important points for biological regulation that can be perturbed in genetic diseases.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":235075915,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1126\/sciadv.abg0942","PubMedCentral":"8139590","ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.research-collection.ethz.ch\/bitstream\/20.500.11850\/488246\/3\/eabg0942.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"etection of a cardiac mass has a direct therapeutic implication because of its potential for pulmonary or systemic embolization. The choice of treatment is dependent upon the time of the embolization, clinical presentation and type of embolic mass. Imaging features in combination with clinical and laboratory findings are usually helpful in the differentiation of various cardiac masses with high probability. The case we are presenting is a 73-year-old man with occlusion of both pulmonary arteries and a right atrial thrombus initially diagnosed as a myxoma.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":21986649,"openaccessinfo":{"externalids":{"MAG":"966461158","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper addresses faculty recruitment for online programs. Related issues are faculty perceptions, program processes, and administrative supports. At traditional academic institutions, it is a challenge for program administrators to recruit admirable faculty members to teach in the online programs. The complaints and concerns expressed by the detractors need to be addressed in order to create a positive environment for the online programs. In this paper we propose a model for faculty recruitment, taking into consideration areas of concern and contention, and suggest strategies to appropriately meet the challenges. Based on survey results, we suggest several criteria to be used in selecting online faculty members.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":155810974,"openaccessinfo":{"externalids":{"MAG":"2216806809","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Over the past century, scientific advances in diagnostic devices have offered new potential for noninvasive diagnoses and entrenched computed tomography as a critical component of today's health services. The multidisciplinary field of health image analysis is one of the key areas of innovation that represents these achievements. This area of rapid growth deals with a wide range of operations that support the whole data flow in current health monitoring systems (from raw data capture through digital image transfer). These technologies now have better spatial and luminance resolutions, as well as quicker collection periods, resulting in a large volume of high critical image files that must be appropriately processed and evaluated in order to provide reliable diagnostics findings. This article examines the core kinds of clinical image analysis, as well as the background of various imaging technologies and the major difficulties and developments in the field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244471027,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.53759\/0088\/jbsha202101010","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.53759\/0088\/jbsha202101010","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"AIMS AND OBJECTIVES\nTo explore hospital nurses' experience assessing changes in the health status of stem-cell transplanted patients in home care (HC).\n\n\nBACKGROUND\nStem-cell transplanted patients in HC are treated at home instead of in hospital wards. Hospital nurses visit patients daily and play a key role in assessing the patients' health status. Previous studies on HC for stem-cell transplanted patients focus mainly on safety in HC versus hospital care. No studies regarding nurses' experience assessing patients' health status at home when patients undergo stem-cell transplantation were found.\n\n\nDESIGN\nQualitative study with an explorative design.\n\n\nMETHODS\nData were collected via 14 individual semi-structured interviews with hospital nurses working with stem-cell transplanted patients in HC. Data were analysed using systematic text condensation. The reporting of the study was guided by the COREQ checklist.\n\n\nRESULTS\nThree categories emerged from the data analysis: 1) Effective communication and clinical intuition enhances the assessment of patients' general health condition; 2) It is challenging to rely on one's own judgment in remote assessment; and 3) There are key facilitators in performing remote clinical assessments.\n\n\nCONCLUSIONS\nEffective communication and clinical intuition enhanced the assessment of patients' general health conditions. The lack of physical presence during remote assessments made using clinical intuition in the assessment process difficult. Experience with hematopoietic stem-cell transplantation was seen as important to facilitate accurate remote clinical assessments.\n\n\nRELEVANCE TO CLINICAL PRACTICE\nNurses with responsibility for hospital at-home telephone care should receive training in remote communication and should shadow hospital at-home nurses during in home visits to gain experience assessing patients' health status. Telehealth aspects such as videoconferencing and remote patient monitoring should be considered for more accurate remote assessment. This could potentially result in more effective assessments and reduced readmissions and could promote nurses' confidence in their assessments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244684735,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/jocn.16155","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/jocn.16155","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The self-assembly of guanosine (G) molecules on solid surfaces is investigated by tapping-mode atomic force microscopy (AFM) upon controlling and introducing external factors (stimuli) to the G stock solution such as incubation time, presence\/absence of metal cations, and mechanical shaking. Surprisingly, at different stages of incubation time at room temperature and in the absence of any metal cations in the G stock solution, which are known to be one of the governing factors in forming G-nanostructures, two assembly pathways resulting into two distinct supramolecular nanostructures were revealed. Astonishingly, by introducing a mechanical shaking of the tube containing the G stock solution, one-dimensional (1D) wires of G molecules are observed by AFM, and very interestingly, novel \"branched\" supramolecular nanostructures are formed. We have also observed that the later branched G nanostructures can grow further into a two-dimensional (2D) thin film by increasing the incubation time of the G stock solution at room temperature after it is exposed to the external mechanical stimuli. The self-assembled nanostructures of G molecules are changed significantly by tuning the assembly conditions, which show that it is indeed possible to grow complex 2D nanostructures from simple nucleoside molecules.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36776442,"openaccessinfo":{"externalids":{"MAG":"2076561252","ACL":null,"DOI":"10.1021\/la900640f","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There was permeated by the struggles of eminence Vs illegibility on women and concerned issues from the found of the First International to Comintern in 1919. Women were silent and absent in the First International, and they tried to struggle for the eminence of women issues and women themselves in the Second International and after all they won somewhat eminence. In Comintern, women's eminence was institutionalized in the proletariate and Communist Parties under the lead of Lenin, Zetkin and others so that women won't be easily erased any more in the proletariate revolution. However, the relative eminence came along with illegibility which is the fate waiting for the women in the proletariate revolution. The CCP published the resolution on women and set up the Women Section at the beginning of its found which open some place, which is restricted then, for women in Chinese proletariate revolution under the Comintern's surveillance. The women proletariate hover between the eminence and illegibility because the CCP was always wary that women would be eminent \"excessively\".","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":156355177,"openaccessinfo":{"externalids":{"MAG":"2359370179","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Forest beekeeping is an example par excellence of a sustainable rural enterprise, providing many benefits to trees, humans, and honeybees. It offers a good way for local communities to create income from natural resources without damaging them. In the context of the primary forests of the Russian Far East, forest beekeeping depends on the well-being of nectar-giving linden trees, which have been logged over permitted volumes and soon will be lost entirely. Primorsky forest beekeepers have become the natural allies of environmentalists and have a strong interest in the stewardship of the land and forests.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":229597342,"openaccessinfo":{"externalids":{"MAG":"3108566652","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Genome-enabled prediction of breeding values using high-density panels (HDP) can be highly accurate, even for young sires. However, the cost of the assay may limit its use to elite animals only. Low-density panels (LDP) containing a subset of single nucleotide polymorphisms (SNP) may give reasonably accurate predictions and could be used cost-effectively with young males and females. This study evaluates strategies for selecting subsets of SNP for several traits, compares predictive ability of LDP with that of HDP, and assesses the benefits of including parent average (PA) as a predictor in models using LDP. Data consisting of progeny-test predicted transmitting ability (PTA) for net merit and 6 other traits of economic interest from 4,783 Holstein sires were evaluated using testing and training sets with regressions on their high-density genotypes and parent averages for net merit index. Additionally, SNP subsets of different sizes were selected using different strategies, including the \"best\" SNP based on the absolute values of their estimated effects from HDP models for either the trait itself or lifetime net merit, and evenly spaced (ES) SNP across the genome. Overall, HDP models had the best predictive ability, setting an upper bound for the predictive ability of LDP sets. Low-density panels targeting the SNP with strongest effects (for either a single trait or lifetime net merit) provided reasonably accurate predictions and generally outperformed predictions based on evenly spaced SNP. For example, evenly spaced sets would require at least 5,000 to 7,500 SNP to reach 95% of the predictive ability provided by HDP. On the other hand, this level of predictive ability can be achieved with sets of 2,000 SNP when SNP are selected based on magnitude of estimated effects for the trait. Accuracy of predictions based on LDP can be improved markedly by including parent average as a fixed effect in the model; for example, a set with the 1,000 best SNP using the parent average achieved the 95% of the accuracy of a HDP model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21358026,"openaccessinfo":{"externalids":{"MAG":"2066745970","ACL":null,"DOI":"10.3168\/jds.2010-3335","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific-oa","url":"http:\/\/www.journalofdairyscience.org\/article\/S0022030210006466\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The authors have been engaged for the last two years on a wide project of tabulation of ladder coefficients and subsidiary data for an important class of filters, designed on the basis of insertion loss theory and having Tchebycheff behavior in both the pass and the suppression bands. All calculations were done on the English Electric Digital Computer DEUCE (Digital Electronic Universal Computing Engine) by A. K. Rhodes, who was responsible for programming, computation, and tabulation of the results. The tables have now been ready for some time and publication of a volume \"Tables of Ladder Coefficients and Related Data for Symmetrical and Inverse Impedance Filters,\" embodying these as well as a detailed instruction for their use is expected to take place early in 1959. The aim of this article is to describe generally the contents of these tables and also to relate certain interesting features of the programs used, as well as difficulties encountered during computation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":110849839,"openaccessinfo":{"externalids":{"MAG":"2077419486","ACL":null,"DOI":"10.1109\/TCT.1958.1086484","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel polarization switchable antenna is explored. The antenna has two stable states, right-hand circular polarization (RHCP) state and left-hand polarization (LHCP) state. The sense of polarization of this antenna can be switched easily by mechanical rotation. The proposed antenna is analyzed using simulations and measurements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26815767,"openaccessinfo":{"externalids":{"MAG":"2546724837","ACL":null,"DOI":"10.1109\/APS.2016.7696540","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Results of an analytical investigation on the influence of bond thickness upon the stress distribution in singlelap adhesive joints are presented. The present work extends the basic approach for bonded joints, orginally introduced by Goland and Reissner, through use of a more complete shear-strain\/displacement equation for the adhesive layer. This refinement was not found to be included in any of the numerous analytical investigations reviewed. As a result of the approach employed, the present work uncovers several interesting phenomena without adding any significant complication to the analysis. Besides modifying some coefficients in the shear stress equations, completely new terms in the differential equation and boundary conditions for bond peel stress are obtained. Sn addition, a variation of shear stress through the bond thickness, no matter how thin it may be, is analytically predicted only by the present theory. This through-the-bond-thickness variation of shear stress identifies two antisymmetrical adherend-bond interface points at which the shear stresses are highest. The growth of joint failures originating from these points agrees with results obtained from actual experiments.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":122985382,"openaccessinfo":{"externalids":{"MAG":"2115395169","ACL":null,"DOI":"10.2514\/3.60878","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Many real-world combinatorial problems exhibit structure in the way in which their variables interact. Such structure can be exploited in the form of \"factors\" for representational as well as computational benefits. Factored representations are extensively used in probabilistic reasoning, constraint satisfaction, planning, and decision theory. In this paper, we formulate the factored shortest path problem (FSPP) on a collection of constraints interpreted as factors of a high-dimensional map. We show that the FSPP is not only a generalization of the regular shortest path problem but also particularly relevant to robotics. We develop factored-space heuristics for A* and prove that they are admissible and consistent. We provide experimental results on both random and handcrafted instances as well as on an example robotics domain to show that A* with factored-space heuristics outperforms A* with the Manhattan Distance heuristic in many cases.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":49410305,"openaccessinfo":{"externalids":{"MAG":"2810017341","ACL":null,"DOI":"10.1609\/icaps.v28i1.13932","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1609\/icaps.v28i1.13932","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Lipid profile is a panel of blood tests used as a screening tool for dyslipidaemia. Dyslipidaemia is defined as disturbances of cholesterol and triglyceride levels and recognized as risk factor for cardiovascular disease s. It includes total cholesterol , low density lipoproteins (LDL), high density lipoproteins (HDL), very low density lipoproteins (VLDL) and triglycerides . This study assesses the prevalence of dyslipidaemia among apparently healthy individuals in physically fit defence service personnel and their dependents who reported for their periodic medical examination\/periodic reviews advised by the specialist or who were advised a lipid profile test from the out-patient department by the internist. The values of fasting and non-fasting lipid testing were compared to analyse any advantage of fasting samples over non-fasting samples. Diabetes mellitus was the most common co-morbidity associated with dyslipidaemia followed closely by hypertension. BMI of more than 25 is associated with elevated blood sugar levels. There was no difference in the values of serum triglycerides in both fasting and non-fasting samples whereas there was significant rise in HDL and LDL levels in non-fasting samples. A noteworthy number of apparently healthy and fit individuals had visceral fat of more than 12% which is a risk factor for cardiovascular disease. Keywords: Body mass index, dyslipidaemia, fasting, lipid profile, metabolic syndrome, non-fasting, visceral fat Cite this Article Gurmeet Singh Sarla, R. Girish, Anshuman Singh. Dyslipidaemia and its Association with Fasting versus Non Fasting Lipid Profile Values. Research & Reviews: Journal of Medicine . 2020; 10(2): 26\u201331p.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":224955127,"openaccessinfo":{"externalids":{"MAG":"3087503490","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper discusses the problem of the detection of audible resonances. The basic psychoacoustic researches have shown that the threshold of resonance detection can be classified by resonance level and Q-factor. In this work a third criteria is introduced. It is the energy of the resonance. By analyzing the influence of resonances on the frequency response and group delay, it is shown that it is almost impossible to detect resonances that are near the threshold of audibility. Finally, three common techniques for resonance detection are compared: the cumulative spectral decay, the shaped sine burst decay and the transfer function pole\u2013zero identification. In the conclusion suggestions for the use of the particular method are given.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":199396747,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A preponderance of patients with neuroendocrine tumors (NETs) will experience hepatic metastases during the course of their disease. Many diagnoses of NETs are made only after the neoplasms have spread from their primary gastroenteropancreatic sites to the liver. This paper reviews current evidence-based treatments for neuroendocrine hepatic metastases, encompassing surgery, hepatic artery embolization (HAE) and chemoembolization (HACE), radioembolization, hepatic artery infusion (HAI), thermal ablation (radiofrequency, microwave, and cryoablation), alcohol ablation, and liver transplantation as therapeutic modalities. Consideration of a multidisciplinary approach to liver-directed therapy is strongly encouraged to limit morbidity and mortality in this patient population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7751405,"openaccessinfo":{"externalids":{"MAG":"2040879404","ACL":null,"DOI":"10.4061\/2011\/452343","PubMedCentral":"3205732","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.4061\/2011\/452343","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This is a final report on the results of measurements of neutron irradiation creep which have been performed in non-instrumented creep rigs (Trieste) on many different stainless steel alloys during the last fifteen years in high flux positions in the High Flux Reactor (HFR) at Petten. The creep elongations were measured in hot cells during reactor shut down periods. A few investigations of the creep elongation were performed in fully instrumented creep rigs (Crisp). All the materials were irradiated in the as-received state, which was usually a type of solution-annealed state, after annealing at 400, or at 600, or at 800 C, and after 20% cold work. The irradiation temperature ranged from 300 to 500 C and the applied stresses were between 25 and 300 MPa. The variations in length found up to irradiation doses of about 5 dpa are mainly attributed to the formation of radiation-induced microstructural changes, which are connected either with increases or with decreases in the volume of the materials. The authors are advancing an interpretation of the data which is not without contradictions. They believe that among the many microstructural changes only the formation of carbides, which is connected with an increase in volume, andmore\u00a0\u00bb only the formation of {alpha}-ferrite, which is connected with a decrease in volume, are of importance. The {alpha}-ferrite phase is very brittle, decreasing the ductility of the stainless steels dramatically. An almost thermal equilibrium state of microstructure while irradiating with high energy particles is obtained after about 5 dpa, depending also on the irradiation temperature. The increase in length obtained for doses larger than 5 dpa is attributed mainly to irradiation creep. The normalized creep rates for all stainless steel materials are almost equal in HFR, ORR, and in EBR II. The creep rates increase linearly with stress and flux, and they are slightly dependent on the irradiation temperature (Q{sub irr.} = 0.132 eV) for irradiation temperatures below about 450 C. For irradiation temperatures above 450 C a contribution of thermal vacancies to irradiation creep is noticed and the irradiation creep rates can no longer be ascribed to a simple irradiation creep relation.\u00ab\u00a0less","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":136902801,"openaccessinfo":{"externalids":{"MAG":"2109496943","ACL":null,"DOI":"10.1520\/STP13901S","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: This study aimed to investigate the impact of image preprocessing steps, including Gray Level Discretization (GLD) and different Interpolation Algorithms (IA) on 18F-Fluorodeoxyglucose (18F-FDG) radiomics features in Non-Small Cell Lung Cancer (NSCLC). \nMaterials and Methods: One hundred and seventy-two radiomics features from the first-, second-, and higher-order statistic features were calculated from a set of Positron Emission Tomography\/Computed Tomography (PET\/CT) images of 20 non-small cell lung cancer delineated tumors with volumes ranging from 10 to 418 cm3 regarding five intensity discretization schemes with the number of gray levels of 16, 32, 64, 128, and 256, and four Interpolation algorithms, including nearest neighbor, tricubic convolution and tricubic spline interpolation, and trilinear were used. Segmentation was based on 3D region growing-based. The Intraclass Correlation Coefficient (ICC), Overall Concordance Correlation Coefficient (OCCC), and Coefficient Of Variations (COV) were calculated to demonstrate the features' variability and select robust features. ICC and OCCC < 0.5 presented weak reliability, ICC and OCCC between 0.5 and 0.75 illustrated appropriate reliability, values within 0.75 and 0.9 showed satisfying reliability, and values higher than 0.90 indicate exceptional reliability. Besides, features with less than 10% COV have been selected as robust features. \nResults: All morphology family (except four features), statistic, and Intensity volume histogram families were not affected by GLD and IA. And the rest of them, 10 and 61 features showed COV \u2264 5% against GLD and IA, respectively. Ten and 80 features showed excellent reliability (ICC values greater than 0.90) against GLD and IA. Eight and 60 features showed OCCC\u22650.90 against GLD and IA, respectively. Based on our results Inverse difference normalized and Inverse difference moment normalized from Grey Level Co-occurrence Matrix (GLCM) were the most robust features against GLD and Skewness from intensity histogram family and Inverse difference normalized and Inverse difference moment normalized from GLCM were the most robust features against IA. \nConclusion: Preprocessing can substantially impact the 18F-FDG PET image radiomic features in NSCLC. The impact of gray level discretization on radiomics features is significant and more than Interpolation algorithms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":244287725,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18502\/fbt.v8i4.7754","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.18502\/fbt.v8i4.7754","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective: To investigate investigated the association of hemoglobin (Hb) concentration, hematocrit (Hct) and blood pressure (BP) in children and adolescents.Methods: The study population consisted of a total 7,950 subjects (4,229 boys, 3,721 girls) aged 10 to 18 years who participated in the Korea National Health and Nutrition Examination Surveys conducted between 2007 and 2017.Results: The prevalence of hypertension is estimated about 19.19% (21.51% for boys and 16.5% for girls). The prevalence of obesity is estimated about 9.59% (10.5% for boys and 8.6% for girls). Hb and Hct level tended to increase with the degree of obesity and blood pressure. The systolic BP (SBP) and diastolic BP (DBP) have positively correlated with Hb and Hct levels in both sex. In the multiple regression analysis, the Hb and Hct presented positive association with SBP and DBP after adjustment for for age, BMI SDS, alcohol consumption, smoking physical activity, rural residence, household income, diagnosis of T2DM, hypertension, and dyslipidemia.Conclusion: Hemoglobin and hematocrit levels were positively associated with SBP and DBP, in children and adolescent, aged 10- 18 year.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":234014568,"openaccessinfo":{"externalids":{"MAG":"3128478994","ACL":null,"DOI":"10.21203\/RS.3.RS-154577\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Moses Lake Project (project No. 199502800) was first funded by Bonneville Power Administration during the FY 99. Work commenced and proceeded through September 2001 when questions arouse on the Scope of Work. Due to funding issues at the beginning of FY 2001 we were unable to secure monies to continue with our proposed scope of work. Consequently, the Moses Lake Project was reduced to one full-time employee. An extension of fifty thousand dollars was granted in which the project with one remaining member by October 2001 continued to operate. By December 2001 the NWPPC granted an additional 20K in spending to secure an advisor that could assist in providing a proposal that the ISRP would find amenable. By Jan 2002, the Moses Lake staff put Dr. David Bennett, from the University of Idaho on payroll. With the guidance of Dr. Bennett the Moses Lake project staff was successful in turning in a new version of the proposal and ultimately received funding by July of 2002. Consequently, the lack of manpower and time spent revising and resubmitting said proposal hampered progress. Consequently, this report covers work conducted on the original Scope of Work (SOW) to July 2002 and then follows the new and accepted SOW from July 2002 through September 2002. Work on the tasks within the newest proposal began prior to official acceptance so as not to loose the window of opportunity to collect data during the summer field season. As of July 2000 we moved forward and began the appropriate tasks outlined in our scope of work. Therefore, portions of the FY 2001 annual report address tasks outlined in the original (appendix 1, original FY2000 SOW) and newest scope(s) of work (Appendix 2, new FY 2000 SOW).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129530324,"openaccessinfo":{"externalids":{"MAG":"2029498424","ACL":null,"DOI":"10.2172\/812706","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/digital.library.unt.edu\/ark:\/67531\/metadc734769\/m2\/1\/high_res_d\/812706.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Variational principles have a long story in the study of the time evolution of dissipative systems. There is a wide variety of formulations of such principles, some of which are ad hoc techniques like doubling of the dynamic variables, restricted variations, etc. There also exist some principles which have a fundamental character like the minimum entropy production principle, MEPP, which refers to the stationary state eventually reached by a system after it has been taken out of equilibrium. Much has been discussed whether the MEPP has general application or whether it is of rather limited validity. In particular, it has been concluded that for systems with constant phenomenological Onsager coefficients the entropy production can only decrease in time until a minimum is reached when the system is in the stationary state, it yet being on debate. In this work heat transport in non-homogeneous solids is considered. We study the case of solids with internal structure within the framework of a two temperature description. The internal structure is introduced in the model through the dependence of the thermal conductivity on position. The time evolution equations are obtained through the usual methods of irreversible thermodynamics and from the MEPP. We find that in our approach both sets of evolution equations coincide and that, without imposing any restriction on the phenomenological coefficients other than those coming from the internal structuring of the solid, the appropriate temperature profiles are obtained. We exemplify this finding with the case of pure Aluminum subjected to a heat pulse.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":236594852,"openaccessinfo":{"externalids":{"MAG":"3160560992","ACL":null,"DOI":"10.3390\/ENTROPY2021-09801","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Various cell types can produce the chemokine CXCL10 in response to IFN-\u03b3 stimulation. CXCL10 is generally viewed as a proinflammatory chemokine that promotes recruitment of CD8+ and Th1-type CD4+ effector T cells to infected or inflamed nonlymphoid tissues. We show that CXCL10 plays a role during CD8+ T cell priming in the mouse. Genome-wide expression profiling revealed the Cxcl10 gene as a target of CD27\/CD70 costimulation in newly activated CD8+ T cells. CD27\/CD70 costimulation is known to promote activated T cell survival, but CXCL10 did not affect survival or proliferation of primed CD8+ T cells in vitro. Accordingly, CXCL10 could not fully rescue CD27 deficiency in mice infected with influenza virus. Rather, CXCL10 acted as chemoattractant for other activated CD8+ T cells. It signaled downstream of CD27 in a paracrine fashion to promote generation of the CD8+ effector T cell pool in the Ag-draining lymph nodes. Consistently, CD8+ T cells required expression of the CXCL10 receptor CXCR3 for their clonal expansion in a CD27\/CD70-dependent peptide-immunization model. Our findings indicate that CXCL10, produced by primed CD8+ T cells in response to CD27\/CD70 costimulation, signals to other primed CD8+ T cells in the lymph node microenvironment to facilitate their participation in the CD8+ effector T cell pool.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21509393,"openaccessinfo":{"externalids":{"MAG":"2171863801","ACL":null,"DOI":"10.4049\/jimmunol.1202222","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jimmunol.org\/content\/jimmunol\/191\/6\/3025.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Low temperature electrical measurements of conductivity, the Hall effect and magnetoconductance were performed on a degenerate AlGaN sample. The sample exhibited negative magnetoconductance at low magnetic fields and low temperatures, with the magnitude being systematically dependent on temperature. The measured magnetoconductance was compared with models proposed previously by Sondheimer and Wilson [Proc. R. Soc. Lond. Ser. A 190 (1947) p. 435] and Lee and Ramakrishan [Rev. Mod. Phys. 57 (1985) p. 287]. Data were analyzed as the sum of the contribution of a two-band and electron\u2013electron interactions to the magnetoconductance, applying these models to describe the observed behavior. Least-squares fits to the data are presented. In the sample, magnetoconductance can be explained reasonably well by assuming these contributions to the measured magnetoconductance. It was found that theoretical and experimental data were in excellent agreement.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":98534984,"openaccessinfo":{"externalids":{"MAG":"2109435055","ACL":null,"DOI":"10.1080\/14786435.2010.492357","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/repository.bilkent.edu.tr\/bitstream\/11693\/22243\/1\/%28d%c3%bcz%29Contributions%20of%20impurity%20band%20and%20electron%20electron%20interactions%20to%20magnetoconductance%20in%20AlGaN.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Frequent outbreaks of citrus gummosis in Kenyan citrus orchards have been reported, yet the identity and distribution of the Phytophthora species causing the disease are unknown. Work was carried out to (i) characterize and identify Phytophthora species associated with citrus gummosis based on cultural and morphological traits and (ii) determine the distribution of these species associated with gummosis in different agroecological zones (AEZ). Some 59 plant and soil samples obtained from symptomatic trees and the rhizosphere were evaluated by direct isolation and baiting, respectively, using Phytophthora semi -selective media. Phytophthora species were identified on the basis of colony morphology, mycelial characteristics, cardinal growth temperatures, morphology and dimensions of sporangia, oogonia and antheridia. For colony morphology and growth temperature studies, a 5 mm diameter mycelial plug of each isolate was transferred to amended cornmeal agar (ACMA) and incubated at 5, 24 and 35\u00b0C for 7 days in the dark. Growth rates were evaluated based on daily records of mycelial growth for 7 days. The occurrence and distribution of these species were determined by recording the number of isolates recovered from samples from each AEZ. P. citrophthora was the most prevalent (76.3 %) of all the Phytophthora species identified in all the AEZs, followed by P. nicotianae (22 %). P. syringae was the least (1.7 %) prevalent. P. citrophthora was the only species present in all AEZs sampled whereas P. nicotianae was confined to the coastal lowlands although also present in other zones in a lower scale. P. syringae was present only in low midland zones and was the only species not found in coastal lowland zones. The forty five isolates of P. citrophthora , thirteen isolates of P. nicotianae and one isolate of P. syringae were tested for virulence on fruits of lemon var. rough lemon. The three most virulent isolates of P. citrophthora , two most virulent isolates of P. nicotianae and the only isolate of P. syringae were selected for pathogenicity testing on lemon seedlings. Based on these studies, it may be concluded that P. citrophthora, P. nicotianae (syn. P. parasitica) and P. syringae are the Phytophthora species associated with citrus gummosis in Kenya. Molecular characterization of the pathogens is recommended to confirm true genetic identity of the species.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56104365,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18697\/ajfand.55.11605","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.18697\/ajfand.55.11605","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Variability of proteins at the sequence level creates an enormous potential for proteome complexity. Exploring the depths and limits of this complexity is an ongoing goal in biology. Here, we systematically survey human and plant high-throughput bottom-up native proteomics data for protein truncation variants, where substantial regions of the full-length protein are missing from an observed protein product. In humans, Arabidopsis, and the green alga Chlamydomonas, approximately one percent of observed proteins show a short form, which we can assign by comparison to RNA isoforms as either likely deriving from transcript-directed processes or limited proteolysis. While some detected protein fragments align with known splice forms and protein cleavage events, multiple examples are previously undescribed, such as our observation of fibrocystin proteolysis and nuclear translocation in a green alga. We find that truncations occur almost entirely between structured protein domains, even when short forms are derived from transcript variants. Intriguingly, multiple endogenous protein truncations of phase-separating translational proteins resemble cleaved proteoforms produced by enteroviruses during infection. Some truncated proteins are also observed in both humans and plants, suggesting that they date to the last eukaryotic common ancestor. Finally, we describe novel proteoform-specific protein complexes, where loss of a domain may accompany complex formation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":252520989,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2022.09.21.508930","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1101\/2022.09.21.508930","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Complete debridement with smear layer removal are essential measures for achieving a successful outcome of root canal treatment. The aim of this study was to evaluate the effects of chitosan at different concentrations on the removal of the smear layer and on dentin structure after 3 and 5 min of application. Twelve recently extracted maxillary canine teeth were instrumented using the crown-down technique and irrigated with 1% sodium hypochlorite. The specimens were distributed according to the time and concentration of the final irrigating solution: G1: 0.1% chitosan for 3 min; G2: 0.2% chitosan for 3 min; G3: 0.37% chitosan for 3 min; G4: 0.1% chitosan for 5 min; G5: 0.2% chitosan for 5 min; G6: 0.37% chitosan for 5 min. All samples were prepared for SEM analysis. G1 exhibited removal of the smear layer, but not the smear plugs. G2 showed visible and open tubules with slight erosion of the peritubular dentin. Cleaning in G3 was similar to that in G2, however, the erosive effect was greater. There was expansion of the diameter of the tubules in G4; and in G5 and G6, there was severe erosion with deterioration of dentin surface. In conclusion, 0.2% chitosan for 3 min appeared to be efficient for removing the smear layer, causing little erosion of dentin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6737332,"openaccessinfo":{"externalids":{"MAG":"2046170255","ACL":null,"DOI":"10.1590\/S0103-64402012000400008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Extracellular ATP has been reported to exert mitogenic and contractile effects on cultured renal mesangial cells (MCs). Since it is possible that these actions involve changes in the cAMP second messenger system, we examined the effect of extracellular nucleotides on the accumulation of cAMP in rat MCs. ATP, UTP and adenosine 5'-0-(3-thio)triphosphate (ATP gamma S) (100 microM) had no significant effects on baseline cAMP levels, but inhibited forskolin-stimulated accumulation of cAMP by 21-75% in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). Maximal inhibitory effects were observed at 100 microM of ATP gamma S with a threshold dose of 1 microM. ATP gamma S, ATP and UTP were the most potent inhibitors indicating stimulation of the P2u receptor. The P2x agonists adenosine 5'-(alpha, beta-methylene) triphosphate and adenosine 5'-(beta, gamma-methylene) triphosphate, and the P2y agonist 2-methylthio-ATP did not affect cAMP accumulation. Treatment with the P2 receptor antagonist suramin (200 microM) reduced the inhibition by 58%. The inhibitory effects of the nucleotides were significantly attenuated by preincubation with pertussis toxin (10-100 ng\/ml). Inhibition of phospholipase C and protein kinase C did not prevent the inhibitory effect of the nucleotides. Inhibitors of forskolin-stimulated cAMP accumulation had different effects on DNA synthesis in cultured MCs as measured by 3H-thymidine uptake at 48 h: ATP, ATP gamma S and the inhibitor of adenylyl cyclase, SQ 22536, stimulated DNA synthesis in MCs, while UTP showed no significant mitogenic effect. Agents which increased baseline levels of intracellular cAMP (forskolin, IBMX, dibutyryl-cAMP) significantly diminished DNA synthesis in MCs. The results indicate that the P2u-purinergic receptor mediates inhibition of forskolin-induced cAMP accumulation which is likely due to inhibition of adenylyl cyclase. This effect appears to be partially mediated by PTX-sensitive G proteins. While the increase in cAMP accumulation is anti-mitogenic, inhibition of cAMP accumulation by P2u receptors is not correlated with MC growth control. Thus, additional mechanisms other than inhibition of cAMP accumulation by P2u receptors are likely to be involved in the mitogenesis of extracellular ATP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23483770,"openaccessinfo":{"externalids":{"MAG":"2085704869","ACL":null,"DOI":"10.1159\/000173919","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Steel fabricator DC Construction has established a solid relationship with the Steelpoort-based Two Rivers PGM mine, having worked on numerous other projects prior to its new tertiary milling plant.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":140042470,"openaccessinfo":{"externalids":{"MAG":"2905977397","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recourse to a loan in the case of individuals is an expression of the growing desire to improve their living conditions, and to be able to purchase goods that meet the requirements of today's life. During the pandemic of SARS-CoV-2, there have been other requirements, different from those of the previous period, and loans could be one of the ways to solve the new problems of the population of Bucharest-Ilfov. The purpose of this study is to analyze the evolution of loans for the population of Bucharest-Ilfov in the pre-pandemic period and from the beginning of the pandemic and to understand the attitude that credit consumers may have during this period. The objectives of the study are to identify how the credited funds were used, in addition to the size of the amounts accessed. The credited amount represents only a dimensional, quantitative component, but what was purchased with the amount accessed through a loan is a qualitative component. The data were provided, without exposing the personal data of those who accessed a loan, by the National Bank, through FGDB. The results provide a clear picture of the increasing trend of the quantitative side, but there is a greater attention between the amounts credited in lei and those in foreign currency. Equally, the purpose for which these funds were accessed was oriented towards the goods of maximum necessity. Of these, real estate occupies a superior position, while the opposite population is loans for tourist services.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":261168663,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.34739\/zn.2021.57.03","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/czasopisma.uph.edu.pl\/znadministracja\/article\/download\/2741\/2384","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Urban soils differ from the natural ones in that they are more strongly influenced by anthropogenic activities. \nThis is especially relevant for Szeged (SE Hungary), where the original surface of the city had been elevated \nby several meters by the intensive anthropogenic activities (infilling) following the Great Flood of 1879. \nSamples were taken at 15 sites during the spring of 2005 from horizons of soil profiles located in this city. The \nmajor aims of this study were the examination and tracing of the diagnostic properties different from natural \nsoils (i.e. artefacts, humus content, humus quality, pH (H2O, KCl), carbonate content, nitrogen content) from \nthe city centre towards the outskirts. In addition, near the profiles average topsoil samples (0\u201310 cm depth, \n2\u20134 m2) were also taken for determining heavy metal concentrations in order to assess the \"toxic\" character \n[FAO (Food and Agriculture Organization of the United Nations), IUSS (International Union of Soil Sciences), \nISRIC (International Soil Reference and Information Centre) 2006. (the first update 2007) World reference \nbase for soil resources. A framework for international classification, correlation and communication, Rome, \nItaly, pp. 128. ISBN: 92-5-105511-4. (http:\/\/www.fao.org\/ag\/agl\/agll\/wrb\/doc\/wrb2006final.pdf)] of the \nprofiles on the one hand, and to differentiate the lithogenic and the artificial origin of these toxic metals \non the other. \nMost of the examined soil parameters are excellent markers of human influence on urban soils. This can be \nseen either in a change in their recorded concentration values or the alteration of their vertical distribution in \nthe profiles. The large number of artefacts, the low and fluctuating humus and nitrogen levels, the poor \nquality of the humic material, the higher and fluctuating carbonate content and a concomitant variance in \nthe pH, the modified mechanical properties all refer to soils affected and transformed by human activities. \nThis is also supported by the statistical analysis of the above mentioned parameters indicating human \ninfluence. The studied horizons were assigned into natural and anthropogenic categories. It proved possible \nto distinguish anthropogenic (Cu, Ni, Pb, Zn) and lithogenic (Co, Cr) heavy metals. The anthropogenic \nelements exceeded the threshold limit values in the studied profiles. Thus, they were categorized as Toxic in \naccordance with the WRB 2006. The studied urban soils of the city of Szeged have been classified in WRB \n(2006) with the help of the above mentioned parameters.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":127132790,"openaccessinfo":{"externalids":{"MAG":"396613597","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider the coherent population trapping phenomenon in a thermal sodium atomic beam. We compare the different coherent population trapping schemes that can be established on the D1 line using the Zeeman sublevels of a given ground hyperfine state. The coherent population trapping preparation is examined by means of a Hanle effect configuration. The efficiency of the coherent population trapping phenomenon has been examined in presence of optical pumping into hyperfine levels external to those of the excited transition. We show that both the contrast and the width of the coherent population trapping resonance strongly decrease when the optical pumping rate is increased. In the experiment, the loss rate due to optical pumping has been controlled by means of a laser repump of variable intensity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1899083,"openaccessinfo":{"externalids":{"MAG":"1590408353","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"physics\/9611007"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We propose a thermodynamic theory for broadband networks relating quantities such as grade of service (GoS), bandwidth assignment, buffer assignment, and bandwidth demand. We propose a scalability postulate for these four quantities. Useful thermodynamic type relationships are then derived. The scalability postulate and thermodynamic type relations are then reexamined via statistical methods using the moment generating function. Large deviations theory is applied, and in the process, notions such as effective bandwidth are defined. We apply this theory to networks which allow dynamic routing of different call types. The probability of rare events expressed in conjunctive forms is characterized using large deviations theory. Based on this theory, a new dynamic routing method called effective bandwidth network routing (EBNR) is proposed. >","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":7207801,"openaccessinfo":{"externalids":{"MAG":"2142326185","ACL":null,"DOI":"10.1109\/49.400655","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Since electron or hole injection is a limiting factor for most electroluminescen t polymers, a matching of the work function of cathodes and anodes and the LUMO \\HOMO energy level of polymers is one of the important factors for high perform ance polymer light emitting devices. In this paper, we report the effect of the cathodes on the performance of the device based on saturated red emitter, three- component copolymer poly (fluorine-co-4, 7-dithien-2-yl-2, 1,3-benzothiadiazole- carbazole or triphenylamine) copolymers. By thermal deposition in combination wi th spin-coating of electron injection layer, we investigated the influence of va rious cathode meterials with different ionization potentials in order to optimiz e the balance of the electron and hole injection. The external quantum efficien cy reached 1.49% with luminance 466cd\/m 2 ,the EL spectrum peak is loc ated at 657nm with the color coordinate: x=0.69, y=0.30 for PFO-5Cz-15DBT.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":138780165,"openaccessinfo":{"externalids":{"MAG":"2263759954","ACL":null,"DOI":"10.7498\/aps.54.5377","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.7498\/aps.54.5377","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"We registered 101 patients from the ambulatory endocrinological dispensary with an endocrine orbitopathy stage II to VI. The peak of age at the time of the disease was in the fifth decennium of age. Females are four times more, frequently affected than males. Only one third of the patients could be registered and treated at the early stage of the endocrine orbitopathy within the first six months after appearance of the symptoms. The metabolic condition of the thyroid gland was hyperthyroid in 70.3% of the cases. 82.2% of all patients showed a struma. By a thyrostatic treatment of hyperthyroid persons in 14.1% a decrease of Hertel's values and in 31.0% a reduction of the subjective eye complaints was obtained. The parabulbar dexamethasone therapy in each case in circa half the patients resulted in an improvement of Hertel's values as well as of the subjective symptoms. A comparison of the oral dexamethasone and prednisolone showed a more favourable effect, when Hertel's values were measured. It is to be stated that there is not therapeutic remedy of choice of the endocrine orbitopathy, but the combination of several forms of treatment is necessary.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33345304,"openaccessinfo":{"externalids":{"MAG":"2411533575","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The large barbs of East Africa are well known for their morphological plasticity. Mitochondrial DNA sequences were compared for specimens of three distinctive barb morphotypes collected syntopically from the Genale River in southeastern Ethiopia. The \"normal,\" \"lipped,\" and \"large-mouthed\" morphotypes are putatively referable to Barbus gananensis. An analysis of molecular variance revealed that the lipped and normal morphotypes are not genetically distinct (\u03d5ST < 0.0001, P = 0.80) and that the group of large-mouthed haplotypes is significantly differentiated from a combined group of normal and lipped haplotypes (\u03d5ST = 0.54, P < 0.001). The evolutionary relationships among the haplotypes were assessed with phylogenetic and minimum-length spanning trees. The results of the phylogenetic and spanning tree analyses are consistent with the analysis of molecular variance. The normal and lipped morphotypes represent morphological variants of B. gananensis, and the large-mouthed morphotype represents a genetically distinctive undescribed species.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":85635750,"openaccessinfo":{"externalids":{"MAG":"2172431828","ACL":null,"DOI":"10.1643\/0045-8511(2001)001[1123:GCOTBC]2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose\nThis paper details a usability testing case study on a simplified homepage for [Library]. The usability testing was completed in Spring 2017 to meet the needs of diverse user groups and shifting trends in Web design and development. At the conclusion of the usability testing, recommendations for change informed the design decisions and a new homepage was implemented in October 2018.\n\n\nDesign\/methodology\/approach\nThe researcher performed eight usability tests with a combination of the different library user types; full-time faculty, students, an administrator and members of the public. The usability test consisted of 13 specific tasks. After testers completed the tasks, users filled out a 30-question Likert-scale questionnaire and answered a set of 8 open-ended questions.\n\n\nFindings\nThis paper discusses the recommendations for change which the researcher discovered at the conclusion of the usability testing period. The research found the need to improve and include specific navigational, visual and easy-to-use elements to best meet the needs of the users in the usability tests. Changes were ranked and implemented on a scale of catastrophic to cosmetic.\n\n\nResearch limitations\/implications\nAs websites, technology and user preferences continually evolve, the homepage will need to be tested for usability again in the next several years. Researchers are encouraged to adapt the methods to their own institutions.\n\n\nPractical implications\nThis paper discusses findings specific to [Library], which in turn has proved to increase usage of certain features and functions by the user community.\n\n\nOriginality\/value\nThis is the first time usability testing has been done for the [Library's] website. It was the first time the design of the homepage was informed by real user preference. This paper is valuable to those looking to create a simple, easy-to-use homepage that best benefits their own unique community of users.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70132121,"openaccessinfo":{"externalids":{"MAG":"2899253253","ACL":null,"DOI":"10.1108\/LHTN-06-2018-0039","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In May 1981 a new disease caused by widespread food poisoning with adulterated rape-seed oil appeared in Spain. A total of 20,640 people were affected and 380 patients have died. The clinical syndrome consisted of pulmonary, neuromuscular, and systemic symptoms, which evolved to produce mild or severe physical disabilities. Although the disease is not primarily a psychiatric condition, almost 8000 TOS patients have been referred to a psychiatrist: these patients show a well-defined post-traumatic stress disorder, vulnerability being associated with female sex, low income, and class and a personal history of \"nervous' disorders. Since January of 1983 the main goal of the health authorities has been social reintegration in the community of TOS patients, and teams of psychiatrists and psychologists have played an important role in this task, moving integrative rehabilitation activities from the hospital into the community.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35938499,"openaccessinfo":{"externalids":{"MAG":"2127597536","ACL":null,"DOI":"10.3109\/03790798709166243","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of the study was to translate 'The COPD self-efficacy scale' (CSES) into Danish and to evaluate the psychometric properties of the Danish version (CSES-DK). CSES enables assessment of self-efficacy in individuals with chronic obstructive pulmonary disease (COPD). The scale consists of 34 items, describing situations which may cause dyspnoea in patients with COPD. The CSES was translated into Danish using a standard forward-backward translation procedure. To estimate the reliability, measurements of internal consistency and repeatability were applied. The validity of the Danish version was evaluated by examining the associations between the CSES-DK score and socio-demographic variables (age, gender, education, disease severity and self-rated health). Factor analysis was conducted to compare the internal structure of the Danish version and the American source version. The study included 151 patients with COPD, recruited from three outpatient clinics. Estimates of reliability were in accordance with the original version of CSES (Cronbach's \u03b1 = 0.97, test-retest r = 0.82, p < 0.001). Significant correlations were obtained between the CSES-DK total score and vocational training and education (r = 0.27, p = 0.001), disease severity (r = -0.27, p = 0.001) and self-rated health (r = -0.41, p < 0.001), indicating construct validity. Five factors were extracted from both versions of CSES. However, in the CSES-DK, only one factor concerns emotions, whereas two factors describing emotions were obtained for the original scale. Furthermore, important discrepancies exist with respect to the direction of the scoring of CSES. In some studies, a high score indicates high self-efficacy, whereas it indicates low self-efficacy in other studies, which complicates the comparison of studies. The Danish version of CSES showed acceptable measurements of reliability and validity. Potential limitations of the scale were identified, and discrepancies exist between the factor structure of the original and Danish version. Consequently, more studies of the factor structure should be conducted on both the original CSES and the translated versions of the instrument.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8282490,"openaccessinfo":{"externalids":{"MAG":"2135836492","ACL":null,"DOI":"10.1111\/j.1471-6712.2011.00963.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/findresearcher.sdu.dk\/ws\/files\/67969330\/2012_Christina_Emme_COPD_self_efficacy_scale_2012.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The dengue virus protease (NS2B-NS3pro) plays a critical role in the dengue viral life cycle, making it an attractive drug target for dengue-related pathologies, including dengue hemorrhagic fever. A number of studies indicate that NS2B-NS3pro undergoes a transition between two widely different conformational states: an \"open\" (inactive) conformation and a \"closed\" (active) conformation. For the past several years, the equilibrium between these states and the resting conformation of NS2B-NS3pro have been debated, although a strong consensus is emerging. To investigate the importance of such conformational states, we developed versions of NS2B-NS3pro that allow us to trap the enzyme in various distinct conformations. Our data from these variants suggest that the enzymatic activity appears to be dependent on the movement of NS2B and may rely on the flexibility of the protease core. Locking the enzyme into the \"closed\" conformation dramatically increased activity, strongly suggesting that the \"closed\" conformation is the active conformation. The observed resting state of the enzyme depends largely on the construct used to express the NS2B-NS3pro complex. In an \"unlinked\" construct, in which the NS2B and NS3 regions exist as independent, co-expressed polypeptides, the enzyme rests predominantly in a \"closed\", active conformation. In contrast, in a \"linked\" construct, in which NS2B and NS3 are attached by a nine-amino acid linker, NS2B-NS3pro adopts a more relaxed, alternative conformation. Nevertheless, even the unlinked construct samples both the \"closed\" and other alternative conformations. Given our findings, and the more realistic resemblance of NS2B-NS3pro to the native enzyme, these data strongly suggest that studies should focus on the \"unlinked\" constructs moving forward. Additionally, the results from these studies provide a more detailed understanding of the various poses of the dengue virus NS2B-NS3 protease and should help guide future drug discovery efforts aimed at this enzyme.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53764449,"openaccessinfo":{"externalids":{"MAG":"2902116048","ACL":null,"DOI":"10.1021\/acs.biochem.8b00978","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Violation much going against the rights of children, government attention is needed in the fulfillment of Human Rights on the right to education of children in Child Penitentiary. Embodiment of the fulfillment of the right to education in Child Correctional Institution is required to support the empowerment of human resources in the future as a pillar of development and life. Article 9 paragraph (1) of Act No. 23 of 2002 states that every child has the right to obtain education and teaching in the context of personal development and level of intelligence in accordance with their interests and talents. This is one of the fundamental importance of education of children in prisons who should still be considered by all parties, both government and society itself. The substance which covers the definition of child described in various laws and regulations vary nationally and internationally by the Convention on Rights of the Child among others, every human being under the age of 18 years unless another set that applies to children determined that early adulthood is achieved. Constraints faced in fulfilling Correctional Institution Children Educate Children education Correctional rights, namely the substance of the Act, the interests and obligations related institutions, students in prisons that are not motivated, infrastructure (facilities construction), Lecturer and staff, quality program development, cooperation and coordination, funding, child welfare and community. Keywrods : student in prisont, education right","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152887879,"openaccessinfo":{"externalids":{"MAG":"1500551010","ACL":null,"DOI":"10.30996\/dih.v8i15.261","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/doi.org\/10.30996\/dih.v8i15.261","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Meta-analytic methods provide a framework around which an inquiry into MAST and SMAST score reliability was completed. Of the 470 measurement opportunities observed between 1971 and 2005, 62 (13.2%) were coupled with accurate reliability information. Weighted reliability estimates centered on. 80 suggesting that the MAST and SMAST generally produce scores of similar and adequate reliability for most research purposes. However, the variability of internal consistency estimates shows that at times these tools will not produce reliable scores, particularly among female and nonclinical respondents. Multiple regression equations provide practical guidelines to improve reliability estimates for the future use of these instruments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9767116,"openaccessinfo":{"externalids":{"MAG":"2016203436","ACL":null,"DOI":"10.1080\/10826080701212295","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Driver oncogenes are defined as oncogenes showing mutations that are responsible for the development and proliferation of malignant neoplasms. Driver mutations represent the Achilles heel of tumors, because tumor proliferation is dramatically suppressed once these gene products are inhibited using specific molecular targeted therapy. Non\u00adsmall-cell lung cancer (NSCLC) was initially sub-classified into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma based on microscopic findings. However, new information on a driver oncogene called epidermal growth factor receptor (EGFR) mutation and its specific inhibitor changed the sub-classification of NSCLC. After the discovery of EGFR mutation and its specific inhibitor, several other driver oncogenes and their specific inhibitors were also discovered, adding to the sub-classification of NSCLC. Consequently, testing for driver oncogenes became essential for selecting the optimal treatment for advanced NSCLC. Earlier, these driver oncogenes were tested for individually, but next-generation sequencing technology \u00ad which enables multiplex driver oncogene testing \u00ad has recently been introduced into daily clinical practice. However, sample quality and quantity are essential in order to obtain complete results of genetic alterations. Treatment with inhibitors against driver oncogenes can shrink tumors dramatically, but tumors become resistant in 10\u00ad18 months. Mechanisms underlying resistance to specific inhibitors have been investigated, and novel drugs have been developed to overcome resistance. However, it remains challenging to cure advanced NSCLC with mutations in driver oncogenes. Therefore, immunotherapy should be introduced with the aim of inhibiting cancer progression long-term, and further investigation is warranted in this regard.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":249151577,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A study of impact damage morphology in unidirectional carbon\/epoxy laminates was performed. A \"load drop\" method was investigated for prediction of the delamination threshold energy (EDT) for impact. The impacted samples were subjected to uniaxial, in-plane compression to observe the growth of damage, failure modes, and residual strength. Samples were scanned before and after CAI using air-coupled throughtransmission ultrasound and amplitude C-scans were collected for visual inspection of damage.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260603577,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: the process of a humanistic instruction constitutes an essential tool to the achievement of high levels in the most important aspects of the student's personality and to accomplish an educational policy; which target is the comprehensive development of the individuals to their interaction in society. Objective: to identify the main manifestations of the regularities of a humanistic instruction process in medical studies at the Medical Science University in Pinar del Rio province. Material and method: a study supported on the dialectic-materialistic method because of its capacity of integrating qualitative and quantitative methods and even to determine a system of methods, thus theoretical, empiric and statistics methods were used as the first ones; historical-logical, systemic-structural and documentary revision. In the second group interviews, surveys and observation methods were followed. Results: no correspondence and interrelation between professional and social acting modes was found. The contents of a humanistic instruction were not observed from its transversal points of view as invariants of knowledge in the disciplines and\/or subjects. Skills and value judgements to interpret the social context and their preparation to transform the health context showed not sufficient integration of knowledge. Conclusions: at the Medical Science University in Pinar del Rio, the process of a humanistic instruction in Medical Studies shows insufficiencies in its implementation, it is not systemic; it is not contextualized and not a sequential follow up of actions responding to the interpretation of a socio-humanistic and ethical context to develop the professional practice was observed as well.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":145339639,"openaccessinfo":{"externalids":{"MAG":"2118399861","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The application of organic matter studies in petroleum exploration had its start with the recognition of \"rank\" in coal. During the period of 1900\u20131925, both physical and chemical methods were developed for determination of the degree of low grade metamorphism of particulate organic materials, or palynodebris in coals and other sediments. Measurements of the relative metamorphism (maturation level) which are based on physical properties are generally quick, cheap, and qualitative to semiquantitative. Those based on chemical analyses are less rapid and tend to be more quantitative. Each method has advantages and disadvantages and they often are combined. Papers included in this course consider methods based on particulate organic matter, reflectance, fluorescence, and geochemistry. A method for integrating the data into a three-dimensional model is included.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":128538355,"openaccessinfo":{"externalids":{"MAG":"1899183096","ACL":null,"DOI":"10.2110\/SCN.82.07","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"How to reconstruct drawing and handwriting traces from surface electromyography (sEMG) signals accurately has attracted a number of researchers recently. An effective algorithm is crucial to reliable reconstruction. Previously, nonlinear regression methods have been utilized successfully to some extent. In the quest to improve the accuracy of transient myoelectric signal decoding, a novel hybrid algorithm KF-GEP fusing Gene Expression Programming (GEP) into Kalman Filter (KF) framework is proposed for sEMG-based drawing trace reconstruction. In this work, the KF-GEP was applied to reconstruct fourteen drawn shapes and ten numeric characters from sEMG signals across five participants. Then the reconstruction performance of KF-GEP, KF and GEP were compared. The experimental results show that the KF-GEP algorithm performs best because it combines the advantages of KF and GEP. The findings add to the literature on the muscle-computer interface and can be introduced to many practical fields.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52895461,"openaccessinfo":{"externalids":{"MAG":"2894993328","ACL":null,"DOI":"10.3390\/s18103296","PubMedCentral":"6210803","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1424-8220\/18\/10\/3296\/pdf?version=1538301979","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT We have isolated uracil-auxotrophic mutants of the hyperthermophilic archaeon Sulfolobus solfataricus in order to explore the genomic stability and mutational frequencies of this organism and to identify complementable recipients for a selectable genetic transformation system. Positive selection of spontaneous mutants resistant to 5-fluoroorotate yielded uracil auxotrophs with frequencies of between 10\u22124 and 10\u22125 per sensitive, viable cell. Four different, nonhomologous insertion sequences (ISs) were identified at different positions within the chromosomal pyrEF locus of these mutants. They ranged in size from 1,058 to 1,439 bp and possessed properties typical of known transposable elements, i.e., terminal inverted repeats, flanking duplicated target sequences, and putative transposase genes encoding motifs that are indicative of the IS4-IS5 IS element families. Between 12 and 25 copies of each IS element were found in chromosomal DNAs by Southern analyses. While characteristic fingerprint patterns created by IS element-specific probes were observed with genomic DNA of different S. solfataricusstrains, no homologous sequences were identified in DNA of other well-characterized strains of the order Sulfolobales.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40750017,"openaccessinfo":{"externalids":{"MAG":"2022530969","ACL":null,"DOI":"10.1128\/JB.182.9.2574-2581.2000","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"What are the macroeconomic implications of having a resource-rich neighbour? The voluminous literature on the curse of natural resources exclusively focuses on \"domestic\" effects; that is, how resource intensity in country i affects country i's development. Still, there are good reasons to believe that the effects of natural resources can spread across the borders. This paper is a first attempt at understanding how the resources located in country j affect the income dynamics of its neighbour country i. Using a standard spatial econometrics approach, a measure of neighbourhood resource intensity is constructed for each of 147 countries. This measure, together with domestic resource intensity and a set of controls to account for the role of geography, culture, and institutional quality, is used as an explanatory variable in income and growth regressions. The main finding is that neighbourhood resource intensity reduces domestic income and growth, while domestic resource intensity has generally no negative effect. Interestingly, the negative spatial effect of natural resources becomes statistically less significant (and possible even insignificant) when neighbourhoods are characterized by higher income and better institutions. This in turn provides some ground for interpretation and policy recommendations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232662020,"openaccessinfo":{"externalids":{"MAG":"3003843548","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Assessment and quantification of Attention, Hyperactivity and Impulsivity symptoms and losses it promotes to an individual is a challenging task. A computerized assessment tool, Quotient ADHD \u00ae System, intends to provide objective measurements of hyperactivity, inattention an impulsivity on an individual basis. In a sample of 64 adults, we correlated results of this tool with scores of self-report scales for ADHD symptoms, impulsiveness and executive functions. Significant Spearman's correlations ( p \u2264.05) were found between Quotient ADHD \u00ae scores and ADHD symptoms, impulsivity and executive function scores. Considering results obtained, we assume Quotient ADHD \u00ae might be a useful instrument to help evaluate inhibition control related to impulsiveness and inattention, suitable for detecting disorders with attention and impulsivity compromise.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264173929,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It has been suggested that masticatory efficiency is directly related to the area of the occlusal surfaces that make contact. However, little work has been carried out to determine if occlusal wear increases the area of contact, and controversy exists as to whether this would be an advantage. Using a wax registration method, occlusal contact area was measured in a group of individuals with either local or generalized wear, before and after treatment. The changes in occlusal contact area were statistically significant for the group exhibiting generalized wear but not for the group exhibiting localized war.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21841909,"openaccessinfo":{"externalids":{"MAG":"2042204650","ACL":null,"DOI":"10.1111\/J.1365-2842.1983.TB00134.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Application of antioxidants is a common way for retarding oxidation. Due to adverse effects of synthetic antioxidants on health, the use of natural and safe antioxidants is considered essential. Pistachio green hull is a waste product and low-cost source of phenolic compounds. The use of phenolic compounds in food formulations has some limitations. In this study, the encapsulation of Pistachio Green Hull (PGH) phenolic compounds was carried out by spray-dryer using Maltodextrin (MD) as a wall material. For this purpose, the effective factors including the inlet temperature, dilution factor, wall:core ratio, and rate of feeding were optimized. MD, PGH extract powder, and encapsulated phenolic compounds produced under optimum conditions (ME) were characterized by Scanning Electron Microscopy (SEM), FTIR, X-ray Diffractometry (XRD), and Differential Scanning Calorimetry (DSC).Under optimum conditions, the amount of phenolic compounds and the encapsulation efficiency were 32.1 mg GAE g dp and 81%, respectively. DSC results showed that the microencapsulation had improved thermal stability of phenolic compounds. The DPPH test results indicated that the antioxidant activity of the free PGH extract was 10% higher than encapsulated one (ME). Storage stability results indicated that the amount of phenolic compounds of PGH extracts and ME after 60 days storage decreased by more than 29 and 4%, respectively. The microcapsules obtained can be used in the production of functional foods and pharmaceutical products, due to their antioxidant content and presence of phenolic","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":231744397,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The principle of operator separation, a generalization of operator splitting, is applied to some problems in reflection seismology. In particular, the examples of wave-equation migration of seismic data in a three-dimensional medium and accurate depth migration in a laterally varying medium are considered in light of this theory. For the case of a stratified three-dimensional medium, the standard dimensional splitting technique used in the downward-continuation step of the migration process can be replaced with full dimensional separation. The computational implications of this result are that the wave field array need only be transposed once during the downward continuation rather than 2n times, where n is the number of finite-difference steps taken in the calculation. For the example of downward continuation in a laterally varying medium, the ideas of operator separation can be used to split the downward continuation operator into two parts, one that looks like the conventional downward-continuation operator for a stratified medium, and a second that represents the correction for the effects of lateral variation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":123034410,"openaccessinfo":{"externalids":{"MAG":"2127742086","ACL":null,"DOI":"10.1190\/1.1441468","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/escholarship.org\/content\/qt7fh0z3q0\/qt7fh0z3q0.pdf?t=qkyrt1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Studies of the American public demonstrate that partisans often diverge not only on questions of opinion but also on matters of fact. However, little is known about partisan divergence in factual beliefs among the government officials who make real policy decisions, or how it compares to belief polarization among the public. This letter describes the first systematic comparison of factual belief polarization between the public and government officials, which we conducted using a paired survey approach. The results indicate that political elites are consistently more accurately informed than the public across a wide range of politically contentious facts. However, this increase in accuracy does not translate into reduced factual belief polarization. These findings demonstrate that a more informed political elite does not necessarily mitigate partisan factual disagreement in policy making.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":229490127,"openaccessinfo":{"externalids":{"MAG":"3109806600","ACL":null,"DOI":"10.1017\/S000712342000037X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The neurofibromatoses are a group of neurocutaneous disorders that show extreme clinical heterogeneity and are characterised by growth abnormalities in tissues derived from the embryonic neural crest.1,2 Two main clinical forms exist, type 1 (NF1) and type 2 (NF2), as well as several alternate and related forms.2,3 NF1 and NF2 are the only clinically well defined disorders and both genes have been identified.4\u20138 The NIH diagnostic criteria for NF1, as defined by the conference statement,9 are met if two or more of the following are found: six or more CAL spots; two or more neurofibromas of any type or one plexiform neurofibroma; axillary or inguinal freckling; optic glioma; two or more Lisch nodules; a distinct osseous lesion; a first degree relative (parent, sib, or offspring) with NF1 according to the above criteria.\n\nSpinal nerve sheath tumours are described as symptomatic findings in only 5% of NF1 patients,10 although they can be observed by MRI in up to 36% of patients.11\u201313 The presence of a wide, symmetrical distribution of spinal neurofibromas, occurring in all adult affected members of the same family and segregating in an autosomal dominant fashion, is however extremely rare. This form, familial spinal NF (FSNF), has been considered an alternate form of NF since patients generally lack dermal neurofibromas and Lisch nodules, both typical hallmarks of NF1, and since symptomatic and generalised spinal neurofibromas are uncommon in classical NF1. FSNF has been reported in only four families.12,14,15 Three multigenerational families with spinal neurofibromas and CAL spots were shown to be linked to markers surrounding the NF1 locus.12,14,15 In the fourth family, presenting with spinal neurofibromas without CAL spots, linkage to the NF1 locus was excluded.14 Only in one FSNF family has \u2026","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":6525878,"openaccessinfo":{"externalids":{"MAG":"2111415109","ACL":null,"DOI":"10.1136\/jmg.40.2.122","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jmg.bmj.com\/content\/jmedgenet\/40\/2\/122.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The pola:dzation of deuterons produced at a center -of-mass angle of 115\u00b0 in the p + p- tr+ + d reaction has been measured using 340\u00b7-Mev un polarized protone. The deuterons were detected in coincidence with the mesons and were analyzed by scattering from a carbon\u00b7target at 24\u00b0. In conjunction with previous experiments on the reaction, this measurement completes the specification of the phenomenological parameters of Rosenfeld and Cell-Mann and Watson. Specifically it permits the determination of the relative phases of the several modes of meson production~ which in turn are related to the p-p phase shifts at this energy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251926710,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: In confined afloat settings, the threat of an acceleration of the Influenza outbreak is substantial, causing high morbidity of the personnel on board, disrupting daily activities, and leading to low crew morale. In this study, H1N1 Influenza outbreak in a Naval Warship and its control measures are described. Materials and Methods: It is a study of 21 clinically suspected cases of H1N1 Influenza. Cases were reported within 3 weeks from a ship company, all of whom were susceptible. They have been described on the basis of demography, clinical features, recent travel history, and history of contact. Results: Mean age of the clinically suspected cases was 26.71 years. Of 21 suspected cases, 14 were found positive for the disease. Nine cases were admitted to the hospital and two developed complications. Attack rate of the disease was 4.83%. Conclusion: In confined afloat settings, prompt public health measures of active case finding, strict isolation, and adherence to hand hygiene, following cough etiquettes and disinfection enhancement, can effectively mitigate the outbreak. Vaccination may not have a role to play if preventive measures are instituted effectively.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":134564901,"openaccessinfo":{"externalids":{"MAG":"2793619493","ACL":null,"DOI":"10.4103\/JMMS.JMMS_70_17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We motivate and explain the DlSCoH project, which uses a publicly deployed spoken dialogue system for conference services to collect a richly annotated corpus of mixed-initiative human- machine spoken dialogues. System users are able to call a phone number and learn about a conference, including paper submission, program, venue, accommodation options and costs, etc. The collected corpus is (1) usable for training, evaluating and comparing statistical models, (2) naturally spoken and task oriented, (3) extendible \/ generalizable, (4) collected using state-of-the-art research and commercial technology, (5) freely available to researchers. We explain the principles behind the dialogue context representations and reward signals collected by the system, as well as the overall system design, call types, and call flow. We also present results regarding the initial ASR models and spoken language understanding models. We expect the resulting corpora to be used in advanced dialogue research over the coming years.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2091520,"openaccessinfo":{"externalids":{"MAG":"2103541438","ACL":null,"DOI":"10.1109\/SLT.2006.326794","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nowadays, the bleaching techniques of thermomechanical pulp(TMP) are fast developing on the strength of some benefits, mainly on low production cost and good fiber property. In this study, the optimum concentration of bleaching chemicals and the environmental load of bleaching wastes were considered to improve the bleaching efficiency of thermomechanical pulp using Korean redpine(Pinus densiflora) under the peroxide-based bleaching system. The optical property of TMP after bleaching was planned to use higher grade of paper, like printing & writting paper, not general newspaper. The concentration of bleaching chemicals, NaOH, Na2SiO3 and EDTA, in hydrogen peroxide bleaching system, on the basis of O.D. pulp was closely influenced on the improvement of TMP brightness. Final target of bleaching efficiency was set up to above 76%-ISO brightness. The optimal target brightness of Korean redpine TMP was reached to 76.45%-ISO under the conditions of H2O2 7% with NaOH 2.20%, Na2SiO3 0.63% and EDTA 0.02%. The concentration of NaOH, Na2SiO3 and EDTA was correlated functional to the residual peroxide content of wastewater, pH value and electric conductivity of TMP fibers after bleaching treatment. The optimal bleaching conditions by controlling the addition amount of chemicals were positively contributed to the brightness stabilization and environmental load of TMP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":93186151,"openaccessinfo":{"externalids":{"MAG":"1510391749","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vagal paragangliomas are rare tumors and difficult to differentiate from carotid body tumors or schwannomas of the vagus nerve. We present a patient who could be preoperatively diagnosed as having a vagal paraganglioma by ultrasonography and color Doppler sonography.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":202647888,"openaccessinfo":{"externalids":{"MAG":"2424570702","ACL":null,"DOI":"10.1159\/000027612","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper we consider the solvability of pseudodifferential operators when the principal symbol vanishes of at least second order at a non-radial involutive manifold $\\Sigma_2$. We shall assume that the subprincipal symbol is of principal type with Hamilton vector field tangent to $\\Sigma_2$ at the characteristics, but transversal to the symplectic leaves of $\\Sigma_2$. We shall also assume that the subprincipal symbol is essentially constant on the leaves of $\\Sigma_2$ and does not satisfy the Nirenberg-Treves condition (${\\Psi}$) on $\\Sigma_2$. In the case when the sign change is of infinite order, we also need a condition on the rate of vanishing of both the Hessian of the principal symbol and the complex part of the gradient of the subprincipal symbol compared with the subprincipal symbol. Under these conditions, we prove that $P$ is not solvable.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":117896838,"openaccessinfo":{"externalids":{"MAG":"1539304044","ACL":null,"DOI":"10.2140\/apde.2017.10.323","PubMedCentral":null,"ArXiv":"1507.05594"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1507.05594","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Summary.\u2002 For phylogenetic comparison of hepatitis B virus (HBV) isolates, often a region of the HBV surface gene is analysed. Because the surface gene completely overlaps the polymerase gene, its evolution is constrained, and it may not be the best choice for genetic comparison of HBV isolates. Analysing serial sample pairs of 33 chronically HBV\u2010infected, untreated patients, with a cumulative follow\u2010up of 184\u2003years, the synonymous and nonsynonymous substitution rates of a part of the overlapping HBV surface and polymerase genes were compared to those of a nonoverlapping part of the HBV core gene. The substitution rate of the HBV core gene was higher (8.15\u2003\u00d7\u200310\u22124vs 4.57\u2003\u00d7\u200310\u22124\u2003substitutions\/site\/year) than that of the surface gene. The difference was mainly due to a significantly lower synonymous substitution rate in the surface gene, with dN\/dS ratios of 0.412 in the core gene and 0.986 in the surface gene. Contrary to the core gene, the number of substitutions in the surface gene was higher in low viraemic hosts, who control HBV infection by suppressing replication. The number of substitutions in the core gene correlated more strongly with the duration of follow\u2010up. The overlapping HBV surface and polymerase genes experience strong negative selection, which limits the number of substitutions. Because the HBV core gene reflects the duration of infection more accurately, it is more suitable for the analysis of short\u2010term viral evolution and of hepatitis B transmission chains.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23382353,"openaccessinfo":{"externalids":{"MAG":"1887231880","ACL":null,"DOI":"10.1111\/j.1365-2893.2011.01506.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A lot of well-known partial differential equations modeling physical systems, such as the heat \nequation, the Schrodinger equation or the wave equation, use temporal change of states. Evolution \nequation is an umbrella term for such equations that can be interpreted as differential \nlaws describing the development of a system or as a mathematical treatment of motion in \ntime. With a solution of an evolution equation, one can predict the future of the corresponding \nphysical system which makes it deterministic. Evolution equations can be treated by an \noperator theoretical approach. They can be rewritten as so-called abstract Cauchy problems which \nare connected to strongly continuous operator semigroups on Banach spaces. However, \nStochastic differential equations, Ornstein\u2013Uhlenbeck processes or Feller processes, give rise to \ntransition semigroups which are in general not strongly continuous. Here bi-continuous semigroups \ncome into play, which form in fact the key subject of this thesis. The research on bi-continuous \nsemigroups was motivated by the work of F. Kuhnemund. In fact, she was the initiator for the \ndevelopment of the theory of bi-continuous semigroups. The main idea is to equip the underlying \nBanach space, on which the corresponding semigroup fails to be strongly continuous with respect \nto the norm, with an additional locally convex topology, which is compatible with the norm topology, \nsuch that the semigroup becomes strongly continuous with respect to this locally convex topology. \nThe work of F. Kuhnemund was followed by research by B. Farkas. He investigated perturbation \ntheory for bi-continuous semigroups. In this thesis we introduce the concept of bi-continuous \nsemigroups and the underlying structure, study the construction of extrapolation and intermediate \nspaces of non-densely defined operators, discuss different perturbation type theorems for \nbi-continuous semigroups and consider flows on networks in connection with bi-continuous semigroups.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":216530257,"openaccessinfo":{"externalids":{"MAG":"3012306128","ACL":null,"DOI":"10.25926\/7SS7-BT33","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective. This work presents an ECG classifier for variable leads as a contribution to the Computing in Cardiology Challenge\/CinC Challenge 2021. It aims to integrate deep and classic machine learning features into a single model, exploring the proper structure and training procedure. Approach. From the initial 88 253 signals, only 84 210 were included. Low quality and unscored recordings were excluded. Three different database subsets of 40 365 recording each were created by dividing in three normal sinus rhythm and sinus bradycardia recordings. Each subset was used to train a different model with shared architecture integrated as an ensemble to provide the final classification through major voting. Models contained a deep branch composed of a modified ResNet with dilation convolutional layers and squeeze and excitation Block that took as input windowed ECG signals. This was concatenated with a wide branch that integrated 20 cardiac rhythm features into a fully connected 3-layered network. Three different training steps were studied: just the deep branch (D), wide integration and training (D+W), and a final fine tuning of the deep branch posterior to wide training (D+W+D). Main Results. Results obtained in a local test set formed by a stratified 12.5% split of the given full dataset were presented for 2-lead and 12-lead models. The best training method was the 3-step D + W + D procedure obtaining a challenge metric of 0.709 and 0.677 for 12 and 2-lead models respectively. Significance. Integration of handcrafted features and deep learning model not only may increase the generalization capacity of the network but also provide a path to add explicit information into the classification decision process. To the best of our knowledge this is the first work studying the training procedure to properly integrate both types of information for ECG signals classification.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252046084,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1361-6579\/ac8f12","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6579\/ac8f12\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The increasing concerns on uranium and rare earth metal ion pollution in the environment require sustainable strategies to remove them from wastewater. The present study reports an eco-friendly approach to convert a kind of protein-rich biomass, brewer's spent grain (BSG), into effective biosorbents for uranyl and rare earth metal ions. The employed method reduces the energy consumption by performing the hydrothermal treatment at a significantly lower temperature (150 \u00b0C) than conventional hydrothermal carbonization. In addition, with the aid of the Maillard reaction between carbohydrates and proteins forming melanoidins, further activation processes are not required. Treatment at 150 \u00b0C for 16 h results in an altered biosorbent (ABSG) with increased content of carboxyl groups (1.46 mmol g\u22121) and a maximum adsorption capacity for La3+, Eu3+, Yb3+ (pH = 5.7) and UO22+ (pH = 4.7) of 38, 68, 46 and 221 mg g\u22121, respectively. Various characterization methods such as FT-IR, 13C CP\/MAS NMR, SEM-EDX and STA-GC-MS analysis were performed to characterize the obtained material and to disclose the adsorption mechanisms. Aside from oxygen-containing functional groups, nitrogen-containing functional groups also contribute to the adsorption. These results strongly indicate that mild hydrothermal treatment of BSG could be applied as a greener, low-cost method to produce effective adsorbents for uranyl and rare earth metal ion removal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234525107,"openaccessinfo":{"externalids":{"MAG":"3113421309","ACL":null,"DOI":"10.1039\/d0ra08164g","PubMedCentral":"9058606","ArXiv":null},"license":"CCBY","url":"https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2020\/ra\/d0ra08164g","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We analyze a nonlinear q-voter model with stochastic noise, interpreted in the social context as independence, on a duplex network. The size of the lobby q (i.e., the pressure group) is a crucial parameter that changes the behavior of the system. The q-voter model has been applied on multiplex networks, and it has been shown that the character of the phase transition depends on the number of levels in the multiplex network as well as on the value of q. The primary aim of this study is to examine phase transition character in the case when on each level of the network the lobby size is different, resulting in two parameters q1 and q2. In a system of a duplex clique (i.e., two fully overlapped complete graphs) we find evidence of successive phase transitions when a continuous phase transition is followed by a discontinuous one or two consecutive discontinuous phase transitions appear, depending on the parameter. When analyzing this system, we even encounter mixed-order (or hybrid) phase transition. The observation of successive phase transitions is a new quantity in binary state opinion formation models and we show that our analytical considerations are fully supported by Monte-Carlo simulations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220713271,"openaccessinfo":{"externalids":{"MAG":"3044340307","ACL":null,"DOI":"10.3390\/e22091018","PubMedCentral":"7597111","ArXiv":"2007.12168"},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1099-4300\/22\/9\/1018\/pdf?version=1600072154","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"An electron density map produced by x-ray diffraction analysis of concanavalin A has been calculated to 4.25 A from data of three isomorphous heavy atom derivatives. The crystals are orthorhombic, with unit-cell dimensions of 63.1, 87.0, and 89.2 A for a, b, and c, respectively. The space group is I222, with eight asymmetric units per unit cell. The crystal asymmetric unit contains 27,000 daltons of protein and reflects the chemically unique component (protomer) within the oligomer. Separate chemical studies indicate that the protomer consists of two different polypeptide chains. Four protomers cluster around the intersection of three mutually perpendicular two-fold rotation axes to form a molecule of 108,000 daltons. The molecule can also be subdivided into two-protomer units of 54,000 daltons. Within the two-protomer unit, there are significantly more contacts joining the protomers than there are between adjacent two-protomer units that form the total molecule. These results provide a possible explanation for disagreement in molecular weights obtained in previous ultracentrifugal studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10153769,"openaccessinfo":{"externalids":{"MAG":"1970253549","ACL":null,"DOI":"10.1073\/PNAS.68.7.1393","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: To evaluate the efficacy and tolerability of adjunctive lamotrigine in primary generalized tonic-clonic (PGTC) seizures in a randomized, double-blind, placebo-controlled trial. Methods: Patients with a diagnosis of epilepsy with PGTC seizures who were receiving one or two antiepileptic drugs at study entry were eligible. Patients with partial seizures were excluded on the basis of seizure history and screening EEGs. The study comprised a baseline phase, an escalation phase during which study medication was titrated to a target dose, and a 12-week maintenance phase during which doses of lamotrigine\/placebo and concomitant antiepileptic drugs were maintained. Results: Of the 121 randomized patients ages 2 to 55 years, 117 (58 lamotrigine, 59 placebo) entered the escalation phase and received study medication. During the escalation and maintenance phases combined, median percent reduction in PGTC seizure frequency was 66.5% with lamotrigine compared with 34.2% with placebo (p = 0.006). The corresponding numbers for lamotrigine and placebo were 60.6% and 32.8% (p = 0.038) during the escalation phase and 81.9% and 43.0% (p = 0.006) during the maintenance phase. During the maintenance phase, 72% of lamotrigine-treated patients compared with 49% of placebo-treated patients experienced a \u226550% reduction in frequency of PGTC seizures (p = 0.014). A similar pattern of results was observed for all generalized seizures. The most common drug-related adverse events were dizziness (5% lamotrigine, 2% placebo), somnolence (5% lamotrigine, 2% placebo), and nausea (5% lamotrigine, 3% placebo). Conclusions: Adjunctive lamotrigine is effective in the treatment of primary generalized tonic-clonic seizures and has a favorable tolerability profile.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12904839,"openaccessinfo":{"externalids":{"MAG":"2099062169","ACL":null,"DOI":"10.1212\/01.wnl.0000187118.19221.e4","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In recent years there has been a considerable growth in the number of teaching assistants (teacher aides in the USA) in UK schools and in the diversity and range of their roles and responsibilities. Although these roles vary in different parts of the UK, an increasing number of assistants now work alongside teachers to support children's learning. Some teaching assistants and instructors are bilingual in the languages spoken by children in their schools and draw on their knowledge of other languages in providing support for children's cognitive and language development. Many bilingual teaching assistants carry out similar roles to their monolingual colleagues but, in addition, are involved in facilitating communication and mediating interaction between home, school and local communities. However, their roles and contribution to children's learning are often not clearly defined and are certainly under\u2010researched.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":144024999,"openaccessinfo":{"externalids":{"MAG":"2016549226","ACL":null,"DOI":"10.1080\/0140672040270209","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Three lines of turkeys were compared for response to an Escherichia coli challenge followed by transport stress (transport). The turkey lines were a slow-growing line selected for increased egg production (egg line), a fast-growing line selected for increased 16-wk BW (F line), and a commercial line (Comm line). Birds were challenged at 14 wk of age with an air sac injection of 5,000 to 10,000 cfu of E. coli. At 8 d postchallenge, birds were subjected to a transport stress procedure that included 12 h of holding time in a transport vehicle. The following morning all birds (n = 10 to 19 birds\/line) were bled. Whole blood was analyzed using the Cell-Dyn 3500 blood analysis system (Abbott Diagnostics), and serum chemistry was measured using the Express Plus analyzer (Ciba-Corning Diagnostics Corp.). Transport significantly decreased the levels of hematocrit, hemoglobin, mean cell volume, mean corpuscular hemoglobin, glucose, triglycerides, cholesterol, phosphorus, iron, albumin, and alkaline phosphatase (AP) and increased the levels of uric acid, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Line differences were variable, but the levels of both iron and AP were least in the fastest-growing Comm line birds and greatest in the slowest-growing egg-line birds with intermediate values in the F line. Iron and AP were also the only parameters influenced by sex, with males having greater levels of both compared with females. The creatine kinase levels were more than 6-fold greater in transported Comm line birds, and iron levels of transported Comm males were 3-fold less than controls. Previously, the growth rate of these lines was positively correlated with increased heterophil to lymphocyte ratios and susceptibility to colibacillosis. The differences seen in the Comm line for these commonly measured blood parameters suggest that they may be useful for profiling flocks to determine their response to transport stress and feed withdrawal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7297281,"openaccessinfo":{"externalids":{"MAG":"1987466795","ACL":null,"DOI":"10.3382\/ps.2008-00128","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.3382\/ps.2008-00128","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"On reviewing Beck and Griffiths' paper we felt that neither of the two patients described had total spinal blocks, since both had good motor power in the arms. We feel that the cases described are similar to our patient with the T, block whose dyspnoea was subjective due to the loss of the intercostal component of respiration and who settled with reassurance and light sedation. General anaesthesia has been a major cause of maternal mortality such that use of regional anaesthesia for emergency Caesarean section has been recommended to increase maternal safety [3]. We feel that subarachnoid block offers a practical and useful alternative to general anaesthesia in patients in whom extradural anaesthesia is not the ideal technique because of inadequate anaesthesia or insufficient time to create an adequate block. Pontefract General Infirmary, J.M. RUTTER Pontefract St. James University Hospital, G . LYONS Leeds","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37654230,"openaccessinfo":{"externalids":{"MAG":"1988554854","ACL":null,"DOI":"10.1111\/J.1365-2044.1993.TB07626.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this thesis I set out to further our understanding of two broad questions, 1) why it is that sexual selection favours the evolution of particular traits and 2) why do the patterns of sexual selection on such traits differ between groups and populations? Specifically, I focused on the role that variation in intrasexual competitive structure, the non-random distribution of socio-competitive environments across individuals, plays in shaping variation in the operation of sexual selection both within and across populations. I explore the roles of three main determinants of competitive structure, namely; population structure, polyandry and non-random variation in the distribution of the intensity of competition. To achieve this, I used a combination of empirical and theoretical tools, using the model system Red junglefowl, Gallus gallus. Throughout this thesis I both develop and employ network quantitative tools as a framework to describe variation in intrasexual competitive structure. Overall, this thesis demonstrates a complex relationship between competitive structure and the operation of sexual selection. This structure can modify the strength and direction of sexual selection operating on phenotypic traits, obscure the operation of selection at the population level and influence the relative roles of pre- and post-copulatory sexual selection. Furthermore, this thesis explores how differences in local ecology can shape competitive structure itself and in turn shape sexual selection. In doing so, this thesis sheds some light on the role that variation in competitive structure may play in shaping the operation of sexual selection both within and between populations and generating the great diversity in sexually-selected traits and behaviours between populations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":82716680,"openaccessinfo":{"externalids":{"MAG":"1421672056","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND & OBJECTIVES\nAmerican Indian (AI) adolescents report higher rates of cannabis use than national U.S. adolescents. Previous study examined interactive relationships between depressed affect and family factors on AI adolescent alcohol use. These factors have not been investigated for cannabis use. We examined whether parental monitoring dampened risk for cannabis use due to depressed affect, and potential moderation by sex. \u00a9 2023 The American Academy of Addiction Psychiatry (AAAP).\n\n\nMETHODS\nWe measured cannabis use, depressed affect, parental monitoring, and sex among reservation area AI youth among students in grades 7-12 attending 45 schools. We used censor inflated regression models to identify parental monitoring as a moderator of the relationship between depressed affect and cannabis use.\n\n\nRESULTS\nIn the logistic portion of censor-inflated models, level of depressed affect and parental monitoring significantly related to last 30-day cannabis use. Higher levels of parental monitoring at lower levels of depressed affect related to lower likelihood of cannabis use. Female students had greater likelihood of endorsing cannabis use at higher levels of depressed affect. In the linear portion of the censor-inflated regression models, sex and level of parental monitoring significantly related to cannabis use frequency. Male students endorsed more frequent cannabis use while higher levels of parental monitoring related to lower frequency of use.\n\n\nDISCUSSION & CONCLUSIONS\nParental monitoring may dampen the effect of depressed affect on cannabis use among AI youth on reservations.\n\n\nSCIENTIFIC SIGNIFICANCE\nFuture interventions should foster skill-building prevention efforts directed at coping with depression, along with parental training for effective monitoring. Special attention to AI female adolescents may be indicated. This article is protected by copyright. All rights reserved.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":257717203,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/ajad.13416","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/ajad.13416","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract. The concentration of the biologically active molecular oxygen gas is of crucial importance for fruits in the metabolic respiration, maturation, and ripening processes. In our study, oxygen content and oxygen transport in fruits, exemplified by apples and guavas, were studied noninvasively by gas in scattering media absorption spectroscopy. The technique is based on the fact that free gases typically have 10,000 times narrower absorption features than the bulk material. The technique was demonstrated in studies of the influence of the fruit skin in regulating the internal oxygen balance, by observing the signal response of the internal oxygen gas to a transient change in the ambient gas concentration on peeled and unpeeled fruits. In addition, the gas exchange rate at different ripening stages was also studied in intact guavas.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206439339,"openaccessinfo":{"externalids":{"MAG":"2564934738","ACL":null,"DOI":"10.1117\/1.JBO.21.12.127007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The following chapters deal with the history of weaving and the methods used by our ancestors. They explain simple weaving processes progressing to more complicated forms of weaving in which the artistic taste of the worker is challenged. The preparation of wool including the art of spinning and dyeing, is discussed along with explanations of labour saving devices which aid the weaver in achieving greater success. Several chapters are based on the workings of different types of looms and patterns that can be adopted for each type. Analysis of different materials and the drafting of new patterns are two other important aspects of weaving included in this informative book, which contains many helpful diagrams and pictures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208339181,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/000841745001700211","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nTo assess the usefulness of circulating IL-16 and RANTES measurements as markers of Graves' orbitopathy (GO) activity and to estimate the role of these cytokines in GO pathogenesis.\n\n\nMATERIAL AND METHODS\n42 individuals were divided into four groups: Group 1 comprised 15 euthyroid patients with clinical symptoms of GO who underwent corticosteroid therapy consisting of intravenous infusions of methylprednisolone (MP) and teleradiotherapy (TR); Group 2 comprised ten patients with hyperthyroid GD (Gtx); Group 3 comprised ten patients with GD in euthyreosis (Geu); and Group 4 comprised seven healthy volunteers age- and sex-matched to Groups 1-3. Serum samples were collected 24 hours before the first dose of MP, 24 hours after the first dose of MP, before TR, and at the end of therapy. Serum IL-16 and RANTES were determined by ELISA and TSH-Rab by RIA.\n\n\nRESULTS\nSerum IL-16 levels in patients with GO were significantly elevated at the end of therapy: 346 pg\/mL (257-538) compared to IL-16 values before treatment: 250 ng\/mL (211-337) and to the control group. RANTES serum concentrations did not significantly differ between studied groups, and immunosuppressive treatment did not influence its level. A negative correlation between TSH-Rab and RANTES was found in all studied groups (R = -0.32, p \u3008 0.01).\n\n\nCONCLUSIONS\nOur data suggests that IL-16 may exert an immunoregulatory effect in Graves' orbitopathy. Serum measurements of both IL-16 and RANTES may be clinically useful; however, establishing their place in the diagnostics and treatment monitoring of GO needs further research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20990727,"openaccessinfo":{"externalids":{"MAG":"2405343640","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Liobagrus kingi is endemic to southwest China and listed as endangered species (IUCN 2012). Genetic diversity is necessary for conservation issue. In studying this, the complete mitochondrial genome sequence of L. kingi has been obtained with PCR, which contains 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and a non-coding control region with the total length of 16,483 bp. The gene arrangement and composition are similar to that of other vertebrates. Most of the genes are encoded on heavy strand, except for eight tRNA and ND6 genes. Just like most other vertebrates, the against bias of G has a universality in different statistical results. The complete mitochondrial genome sequence of L. kingi would contribute to better understand population genetics and protect its genetic diversity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45213539,"openaccessinfo":{"externalids":{"MAG":"2062888202","ACL":null,"DOI":"10.3109\/19401736.2012.760075","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Book publishing will constitute a wasted effort if worthy books are not placed in the hands of readers. The signs are that Nigeria is under-served and the potential book market largely untapped. Although various reasons could be adduced for unwholesome book reading development, publishers need to play their own part in changing situations by publishing books that readers can read and make sure that readers want to read them, and then put them within readers' reach. Book marketing (and publishing) in Nigeria leaves a lot to be desired. To create a reading nation, Nigerian publishers need to operate within the marketing concept in their pursuit of profit and survival by satisfying readers. By so doing, the publishing industry should witness a tremendous change. A change that is not only beneficial to the book industry as a whole but the nation as well, since a reading nation is also a development-oriented nation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":195745717,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Greenhouse gases mainly come from farmland soils. Re-spreading chaff (straw returning) is an effective ecological management in China. Quantitative analysis of straw residues together with reduced fertilization rates can provide a scientific basis for reducing greenhouse gas emissions. A field experiment with six different fertilizer amounts combined with straw residues was carried out in a vegetable field (lettuce-cabbage-chili rotation), including the control (CK), conventional fertilizing (F), straw returning with 100% conventional fertilizing (100FS), straw returning with 70% conventional fertilizing (70FS), straw returning with 60% conventional fertilizing (60FS),and straw returning with 50% conventional fertilizing (50FS). The dynamic characteristics and emission factors of CO2, CH4 and N2O in the soil were analyzed using an in-situ, closed chamber, gas chromatography-based system, from November 2016 to September 2017. The results showed that the emission of CO2, CH4 and N2O has seasonal variation characteristics. The peak value mainly occurred in April to August, and the gas emission peak would appear after fertilizing and irrigating. Compared with F treatment, straw returning with fertilizing treatments reduced the N2O emission fluxes, cumulative emission and emission factor, especially in the 100FS treatment. The N2O cumulative emission and emission factor was 60.76 kg\u00b7hm-2, 0.138 kg\u00b7kg-1 (N2O-N\/N) respectively in 100FS treatment during planting chili was more than that during planting lettuce and cabbage. Moreover, straw returning with reducing conventional fertilizing could reduce the N2O emission factor compared with 100FS treatment. The CO2 emission fluxes 55.28-1831.62[mg\u00b7(m2\u00b7h)-1] and cumulative emission (7502.13-25988.55 kg\u00b7hm-2) in 70FS treatment were lower than that in CK and F treatments, while other treatments increased the CO2 emission fluxes and cumulative emission, especially in 60FS and 50FS treatments. During planting lettuce and cabbage, the CH4 cumulative emission mainly showed negative values in treatments except for CK, indicating that soil could adsorb CH4. Moreover, straw returning with 30%-50% conventional fertilizing treatment could reduce CH4 emission fluxes and cumulative emission during planting chili, but increased in 100FS. Compared with CK and F treatment, generally, straw retuning with conventional fertilizing could significantly increase the global warming potential (GWP) in the study, except for 70FS treatment. 70FS could reduce the CO2, CH4 emission and the GWP of greenhouse gases, but could not significantly affect N2O emission reduction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52296370,"openaccessinfo":{"externalids":{"MAG":"3024829253","ACL":null,"DOI":"10.13227\/j.hjkx.201802087","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper discusses an object handling system using three position-controlled manipulators. Mechanical compliance units are installed between each manipulator tip and its hand in order not to generate an excessive inner forces among manipulators caused by mutual positioning errors. From our previous studies, the kinematic conditions of the compliance units necessary for the position control based coordination are made clear and four passive joints are used here for each compliance unit to satisfy the conditions. In the system, the loads distributed to each manipulator tip are changed according to both the passive joint angles and the grasping points of the handled object. Therefore we firstly obtain the relationship between the grasping points and the distributed loads to each hand and then analyze the relationship between the passive joint angles and the loads given to each manipulator tip. Using these relationships we propose the searching scheme for the optimal grasping poses and passive joint angles. The effectiveness of the proposed scheme and the developed system are verified by a fundamental experiment and simulations.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":41801140,"openaccessinfo":{"externalids":{"MAG":"2013391255","ACL":null,"DOI":"10.1109\/SII.2014.7028080","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As an envisaged future of transportation, self-driving cars are being discussed from various perspectives, including social, economical, engineering, computer science, design, and ethics. On the one hand, self-driving cars present new engineering problems that are being gradually successfully solved. On the other hand, social and ethical problems are typically being presented in the form of an idealized unsolvable decision-making problem, the so-called trolley problem, which is grossly misleading. We argue that an applied engineering ethical approach for the development of new technology is what is needed; the approach should be applied, meaning that it should focus on the analysis of complex real-world engineering problems. Software plays a crucial role for the control of self-driving cars; therefore, software engineering solutions should seriously handle ethical and social considerations. In this paper we take a closer look at the regulative instruments, standards, design, and implementations of components, systems, and services and we present practical social and ethical challenges that have to be met, as well as novel expectations for software engineering.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":199485359,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Policy Points Racism is a fundamental cause of health inequities and disease, which requires policy solutions that address this cause directly rather than only targeting mechanisms. Cultural systems, such as cultural racism, undergird the social conditions that shape racial inequities in health, including social and health policy decision making, governance, practice, and public reception. Policies targeting racial health equity benefit from integrating social theory and meaningful assessments of the social context concerning race, racism, and health.\n\n\nCONTEXT\nImproving the health of the total population may be insufficient in eliminating racial disparities in population health. An expanding commitment to understanding social determinants of health aims to address the social conditions that produce racialized patterns in health inequity. There is also a resurging and evolving interest in the influence of cultural barriers and assets in shaping racial inequities in health. The meaning and function of culture, however, remains underspecified.\n\n\nMETHODS\nThis paper synthesizes analogous but fragmented concepts of cultural threat related to social and racial inequity as examined in public and population health, psychology, sociology, communications, media studies, and law. It draws on an existing typology of culture and social inequity to organize concepts related to cultural racism. Employing a transdisciplinary approach, the paper integrates multiple scholarly perspectives on cultural threat to frame cultural racism as cultural systems that promote false presumptions of white superiority relative to non-whites.\n\n\nFINDINGS\nThe lack of shared conceptual grounding and language regarding cultural threats to health hinders a more precise identification and measurement of cultural processes as well as comparisons of relative prevalence and influence of pathways linking cultural processes and social inequity. Evaluating intersections among culture, structures, and racism is a valuable analytical tool for understanding the production of social and racial inequities in health. To adequately address health inequities rooted in systemic racism, it is imperative to discuss the function of cultural racism in shaping population health in the United States.\n\n\nCONCLUSIONS\nBuilding a culture of health and achieving health equity requires that we assess cultural racism in a more meaningful way. Cultural processes are commonly referenced in health inequity scholarship, but the empirical literature generally lags behind the conceptual emphasis. A rich literature across disciplines has substantively engaged conceptualizations of culture and cultural processes, the importance of these processes as part of a system of racism, and mechanisms that may link cultural threats to health. When integrated, this literature offers essential insights for ways population health may address the complex issue of eradicating racial disparities in health.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":202563991,"openaccessinfo":{"externalids":{"MAG":"2972909698","ACL":null,"DOI":"10.1111\/1468-0009.12411","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/1468-0009.12411","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper resumes recent research on blind equalization based in predictive filter structures. The predictive filter structure is composed by a cascade of an infinite impulse response (IIR) forward prediction error filter and a FIR backward prediction-error filter (also called innovators). This equalizer views the channel as the cascade of a minimum-phase and a maximum-phase systems. The filter structure is optimized with the constant modulus criterion. Simulation results show that in several situations, conventional finite impulse response (FIR) equalizers do not achieve similar convergence properties as those shown by the predictive blind equalizer.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":3}},"corpusid":11469514,"openaccessinfo":{"externalids":{"MAG":"2112687979","ACL":null,"DOI":"10.1109\/SPAWC.1997.630058","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Studies were carried out to develope the most economical and practical methods of packaging and preservation of kimchi, so commercialization of kimchi manufacture could proceed rapidly. The results obtained may be summarized as following. (1) It is generally established that the acceptable range of lactic acid content of kimchi is between 0.4% and 0.75%. Based on sensory evaluation, kimchi having lactic acid content below 0.4% and above 0.75% was not edible, and the time of optimum taste corresponded to the vicinity of 0.5% of lactic acid content. For the refrigeration storage with or without preservatives, the packaging kimchi in plastic film must be done at the lactic acid content of 0.45%, for lactic acid fermentation will continue slowly after the packaging. However, for the heat sterilized kimchi the packaging should be done at the 0.5% of lactic acid content for the best because lactic acid fermentation is completely stopped after the packaging. (2) Polyethylene, polypropylene, and polycello were chosen as suitable packaging materials. Polyethylene is cheapest among them but kimchi packaged in this film was damaged frequently in handling process and gave off kimchi flavor. On the other hand polypropylene also gave off kimchi flavor, but its higher mechanical strength gave better protection to kimchi and it had superior display effect due to the transparancy. Therefore polypropylene made much better packaging material. Polycello proved to be the best packaging material from the standpoint of physical characteristics but its price is higher than that of other plastic films. To be effective, the thickness of plastic films for packaging kimchi must exceed 0.08mm. (3) Keeping property of kimchi appeared to be excellent by means of freezing. However, by the time the frozen kimchi was thawed out at room temperature, moisture loss due to drip was extensive, rendering the kimchi too stringy. (4) Preservation of kimchi at refrigerated temperatures proved to be the best method and under the refrigerated condition the kimchi remained fresh as long as 3 months. The best results were obtained when kimchi was held at . (5) In general, preservatives alone were not too elective in preserving kimchi. Among them potassium sorbate appeared to be most effective with the four fold extension of self-life at and two fold extension at . (6) In heat sterilization the thickness of packaged kimchi product had a geat effect upon the rate of heat penetration. When the thickness ranged from 1.5 to 1.8cm, the kimchi in such package could be sterilized at for 20 minutes. Kimchi so heat treated could be kept at room temperature as long as one month without apparent changes in quality. (7) Among combination methods, preservation at refrigerated and heat sterilization could be favorably combined. When kimchi was stored at after being sterilized at for 20 minutes, it was possible to preserve the kimchi for more than 4 months.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":138754050,"openaccessinfo":{"externalids":{"MAG":"2407401141","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Performance prediction or forecasting sporting outcomes involves a great deal of insight into the particular area one is dealing with, and a considerable amount of intuition about the factors that bear on such outcomes and performances. The mathematical Theory of Evidence offers representation formalisms which grant experts a high degree of freedom when expressing their subjective beliefs in the context of decision-making situations like performance prediction. Furthermore, this reasoning framework incorporates a powerful mechanism to systematically pool the decisions made by individual subject matter experts. The idea behind such a combination of knowledge is to improve the competence (quality) of the overall decision-making process. This paper reports on a performance prediction experiment carried out during the European Football Championship in 1996. Relying on the knowledge of four predictors, Evidence Theory was used to forecast the final scores of all 31 matches. The results of this empirical study are very encouraging.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":15373851,"openaccessinfo":{"externalids":{"MAG":"1495401292","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1302.1523"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Adriamycin (ADR) is a chemotherapeutic drug used to treat tumors in a clinical setting. However, its use is limited by a side effect of cardiotoxicity. Glibenclamide (Gli), an inhibitor of mitochondrial ATP-dependent potassium (K-ATP) channels, blocks the cardioprotective effects of mitochondrial K-ATP channel openers and induces apoptosis in rodent pancreatic islet \u03b2-cell lines. However, little is known about the role of Gli in ADR-induced cardiotoxicity. The present study was designed to investigate the impact of Gli on ADR-induced cardiotoxicity in rats. A total of 60 male Sprague-Dawley rats were divided into the following 4 groups: i) Control; ii) Gli; iii) ADR; and iv) Gli+ADR (n=15 in each). The rats in the ADR and Gli+ADR groups were treated with ADR (intraperitoneal, 2.5 mg\/kg\/week) for 6 weeks. The rats in the Gli and Gli+ADR groups received Gli at a dose of 12 mg\/kg\/day via gastric lavage for 30 days from the eighth week of the study. Following the completion of Gli treatment, cardiac function was assessed by echocardiography, and the rats were sacrificed. The hearts were subsequently harvested for analysis. The rats in the ADR group demonstrated significantly impaired cardiac function and increased levels of oxidative stress, endoplasmic reticulum stress (ERS) and apoptosis in the heart compared with rats in the control and Gli groups (without ADR treatment). These abnormalities were exacerbated by Gli in the Gli+ADR group. Gli treatment decreased cardiac function and significantly increased oxidative stress, ERS and apoptosis levels in myocardial tissues in rats treated with ADR. The findings indicated that Gli triggers oxidative stress-induced ERS, and thus exacerbates ADR-induced cardiotoxicity in rats.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3905113,"openaccessinfo":{"externalids":{"MAG":"2787921133","ACL":null,"DOI":"10.3892\/etm.2018.5862","PubMedCentral":"5840948","ArXiv":null},"license":null,"url":"https:\/\/www.spandidos-publications.com\/10.3892\/etm.2018.5862\/download","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Investigations of the influence of external magnetic field on the shape and structure of the high-voltage gas discharge used for air flow ionization to an ionization degree of up to 10-5 are presented. In the first series of experiments, the discharge current flew along magnetic field lines; and in the second series, the discharge current was transverse to the magnetic field. The discharge shape and structure at different magnetic field intensities were obtained.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":33564242,"openaccessinfo":{"externalids":{"MAG":"2326293626","ACL":null,"DOI":"10.1109\/TPS.2014.2314145","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Air pollutants emitted from landfills affect air quality, contribute to the greenhouse effect and may cause serious problems to human health under certain circumstances. The current study was focused on the determination of air emissions from the Akrotiri landfill site which is located in the Akrotiri area (Chania, Greece). The landfill consists of two phases, phase A (first phase) which is currently closed (operational between 2003 and 2007) and phase B (second phase, operation between 2007 and (foreseen) 2013). Three different emission models (the EPA LandGEM model, the triangular model and the stoichiometric model) were used for the quantification of emissions. The LandGEM 3.02 software was further adopted and used in conjunction with the long-term dispersion model ISC3-LT for the evaluation of the dispersion of gaseous chemical components from the landfill. The emission and meteorological conditions under which the models were applied were based on the worst-case emission scenario. Furthermore, the concentration of hydrogen sulfide, vinyl chloride and benzene were determined in and around the landfill site. The concentrations of hydrogen sulfide and benzene were calculated to be far below the limit value proposed by the World Health Organization (WHO) for human health safety. However, the vinyl chloride concentrations were above the WHO reference lifetime exposure health criteria for the phase B area.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6949958,"openaccessinfo":{"externalids":{"MAG":"1985060491","ACL":null,"DOI":"10.1177\/0734242X09353060","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently we have seen the active penetration of computer algebra systems to the educational process because it allows to form an innovative learning technologies. Almost every branch of mathematics the Maple developed the separate specialized package commands. However, currently these technologies, despite its effectiveness and visibility, for various reasons, are still not common in the classroom. The purpose of this article is to review basic information about the capabilities of computer algebra to solve some common problems of graph theory, and which can be used to solve educational problems. The paper describes the package description commands GraphTheory computer algebra system Maple. The methods of solving some common problems in the theory of graphs in Maple. Using discussed the team package Maple a teacher can illustrate the problem solving in the classroom for the subject of the discrete mathematics","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":61119093,"openaccessinfo":{"externalids":{"MAG":"1934374707","ACL":null,"DOI":"10.15587\/1729-4061.2012.5682","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Background\u2003Ritual behaviour, while often considered as nonpurposeful or problematic, can also be regarded as functional behaviour for individuals with autism spectrum disorders (ASD). This study investigated the types and characteristics of ritual behaviour in children with ASD in a Taiwan context. Methods\u2003Sixty-four primary school teachers, who taught 71 students with ASD, were surveyed. In addition, observations with five children with ASD were conducted, and their parents were interviewed. Two control groups of students with intellectual disability and children without a disability were included in the study. Results\u2003Ritual behaviour occurred in the majority of children with ASD, and across all levels of ability. Prevalence was much higher in the ASD group as compared to the two control groups. These behaviours could be categorised into seven types, and ritual behaviour was strongly associated with sensory sensitivity. Conclusions\u2003Although ritual behaviours were diverse in nature and were common among children with ASD in Taiwan, their frequency may be associated with cultural context.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20205860,"openaccessinfo":{"externalids":{"MAG":"2021179540","ACL":null,"DOI":"10.3109\/13668250903291901","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Jurassic and Cretaceous global palaeogeographic reconstructions show a changing configuration of mountains, land, shallow seas and deep ocean basins, and these are used as input for paleoclimatic modelling. We have generated Oxfordian-Kimmeridgian, Tithonian-Berriasian and Barremian-Hauterivian paleoclimatic maps, showing air pressure, wind directions, humidity zones and areas favourable to upwelling conditions, modelled by the PALEOCLIMATE program and plotted on the palaeogeographic background. Paleoclimate modelling suggests that prevailing Jurassic-Cretaceous winds in the northern Tethys area came from south-south-west, and may have been parallel to the Czorsztyn Ridge, uplifted as a result of extension during the Jurassic supercontinental breakup. Upwelling may have been induced at the southeastern margin of the ridge. The model is consistent with the rock records within the earliest Cretaceous deposits. The presence of phosphates and a palaeoenvironmental analysis of benthic fauna support the upwelling model.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128907871,"openaccessinfo":{"externalids":{"MAG":"2109205970","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mount Merapi Museum is one of the geological museums in Sleman Regency, Yogyakarta. Although as the only geological museum, the development of the museum is still not optimal as an educational tourism museum. This study aims to identify the tourist attraction of the Mount Merapi Museum and develop a conceptual model of development that is in accordance with the characteristics of the museum and the needs of tourists. This study uses a survey research approach. Data were collected by observation, interviews, and documentation. Informants were determined by purposive sampling. The data analysis method used interactive model analysis assisted by SWOT analysis. The results of this study are the identification of the strength of Mount Merapi Museum in the form of content attractiveness, architectural attractiveness, and attractiveness in the form of landscape and market analysis. This research also produces the concept of developing the Mount Merapi Museum based on the Edu-Nature Historical Museum, namely through the application of the interactive product concept. The interactive product development strategies are: dividing content into two thematic spaces, redesigning the plaza of the Mount Merapi simulation space, creating the best spots to enjoy the scenery, and involving the public in staging the story of Mount Merapi which is packaged in a show.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251190041,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.36276\/mws.v20i2.328","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/doi.org\/10.36276\/mws.v20i2.328","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The aim of this article is to review the pathogenetic factors of Alzheimer's disease. Primary correlates of Alzheimer's disease are a dysfunction of and a subsequent decrease in the number of cortical and hippocampal synapses, followed by neurofibrillary and neuritic changes of hippocampal and cortical neurons. While the synapse pathology has been shown to be an early event in Alzheimer's disease, a significant neurofibrillary and neuritic pathology appears to develop only during the course of the disease. Cortical amyloid deposits are an unspecific, age-related phenomenon that can also be found in the brains of the majority of nondemented elderly persons over the age of 65 years. Transgenic amyloid mice proved to be of only limited value as animal models of Alzheimer' disease. According to several studies, there is no correlation between the total number of cortical amyloid plaques and clinical parameters of dementia. However, such a correlation exists with respect to the proportion of neuritic plaques, i.e., with respect to the degree of neuritic degeneration within plaques. In addition to these changes, an interleukin-6 associated inflammatory response has been found in the cortices of Alzheimer patients which is absent in the brains of nondemented elderly persons, and which therefore appears to be a specific element. The significance of changes in the cholinergic neurotransmission for Alzheimer's disease is discussed. Finally, the role of apolipoprotein E and other genetic risk factors is reviewed. In this context it is emphasized that in young persons apolipoprotein E4 is not a suitable early diagnostic marker for Alzheimer's disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23756444,"openaccessinfo":{"externalids":{"MAG":"2412362143","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose \u2013 To propose a categorization of the different conflation procedures at the two basic approaches, non\u2010linguistic and linguistic techniques, and to justify the application of normalization methods within the framework of linguistic techniques.Design\/methodology\/approach \u2013 Presents a range of term conflation methods, that can be used in information retrieval. The uniterm and multiterm variants can be considered equivalent units for the purposes of automatic indexing. Stemming algorithms, segmentation rules, association measures and clustering techniques are well evaluated non\u2010linguistic methods, and experiments with these techniques show a wide variety of results. Alternatively, the lemmatisation and the use of syntactic pattern\u2010matching, through equivalence relations represented in finite\u2010state transducers (FST), are emerging methods for the recognition and standardization of terms.Findings \u2013 The survey attempts to point out the positive and negative effects of the linguistic approach and its poten...","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":18325680,"openaccessinfo":{"externalids":{"MAG":"2065507484","ACL":null,"DOI":"10.1108\/00220410510607507","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Purpose \u2013 The purpose of this article is to introduce an innovative methodology to support manufacturing changes in the foundation of flexibility measurements and evaluations and to integrate this in the companies' internal as well as companies' cross\u2010organisational processes of change management.Design\/methodology\/approach \u2013 The approach consists of two phases: first, a consistent systematics for the production systems flexibility evaluation is presented; second, the change processes are analysed and quantified flexibility indicators are integrated to support the decision \u2013 making process.Findings \u2013 The application of the methodology in manufacturing environments has demonstrated that consideration of flexibility in the production and its integration into the manufacturing change processes has a great potential.Originality\/value \u2013 The originality of this work is in the integrated approach to consider flexibility as support for the change management. In particular the integration of quantified flexibility...","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":9431842,"openaccessinfo":{"externalids":{"MAG":"2089570348","ACL":null,"DOI":"10.1108\/17410380810888102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The role of bacterial growth and translocation for the bioremediation of organic contaminants in the vadose zone is poorly understood. Whereas air-filled pores restrict the mobility of bacteria, diffusion of volatile organic compounds in air is more efficient than in water. Past research, however, has focused on chemotactic swimming of bacteria along gradients of water-dissolved chemicals. In this study we tested if and to what extent Pseudomonas putida PpG7 (NAH7) chemotactically reacts to vapor-phase gradients forming above their swimming medium by the volatilization from a spot source of solid naphthalene. The development of an aqueous naphthalene gradient by air-water partitioning was largely suppressed by means of activated carbon in the agar. Surprisingly, strain PpG7 was repelled by vapor-phase naphthalene although the steady state gaseous concentrations were 50-100 times lower than the aqueous concentrations that result in positive chemotaxis of the same strain. It is thus assumed that the efficient gas-phase diffusion resulting in a steady, and possibly toxic, naphthalene flux to the cells controlled the chemotactic reaction rather than the concentration to which the cells were exposed. To our knowledge this is the first demonstration of apparent chemotactic behavior of bacteria in response to vapor-phase effector gradients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5291807,"openaccessinfo":{"externalids":{"MAG":"2332482703","ACL":null,"DOI":"10.1021\/es100776h","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"cheduling problems are difficult types of production arrangement problems that enumerated among NP-Complete problems. Some of evolutionary algorithms such as Genetic Algorithm, Ant Colony Optimization etc. have been used to solve this problem. In new years, Artificial Immune Algorithm is used to solve optimization problems such as routing and scheduling. One of complex scheduling problems is Job-shop Scheduling problem. In this article we use immune system concepts of human body, to implement a new artificial immune algorithm for solving Job-shop scheduling problem. A new population generation method was proposed based on G&T algorithm. We use two mutation methods, namely Shift Change method and Inverse method in Job-shop scheduling for first time. Moreover, we describe a vaccination method named MCV, to make maximum advance in solutions, and then achieve to more than one optimal solution concurrently and release from local optimum. Finally, we test our method on the very famous benchmark of JSP, namely FT06, then show experimental results and get some conclusions.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2}},"corpusid":16621865,"openaccessinfo":{"externalids":{"MAG":"2122106031","ACL":null,"DOI":"10.5120\/7420-0464","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5120\/7420-0464","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In the rat neocortex, a subset of GABAergic interneurons express the neuropeptide vasoactive intestinal peptide (VIP). Previously, we demonstrated that a population of VIPergic interneurons could be accurately identified by their irregular spiking (IS) pattern and their bipolar morphology. IS interneurons were studied in neocortical slices from 16\u201322\u2010day\u2010old rats using whole\u2010cell recordings, intracellular labelling and single\u2010cell RT\u2010PCR. In response to a depolarizing pulse, IS interneurons typically discharged a burst of action potentials followed by spikes emitted at an irregular frequency. Several seconds of depolarization, micromolar concentrations of 4\u2010aminopyridine, and nanomolar concentrations of either dendrotoxin I or K converted this irregular pattern to a sustained discharge, suggesting the involvement of an ID\u2010like K+ current. The main glutamate receptor subunits detected in IS cells were GluR1 flop and GluR2 flop, GluR5 and GluR6, and NR2B and NR2D for the \u03b1\u2010amino\u20103\u2010hydroxyl\u20105\u2010methyl\u20104\u2010isoxazolepropionic acid (AMPA), kainate and N\u2010methyl\u2010d\u2010aspartic acid (NMDA) subtypes, respectively. Paired whole\u2010cell patch\u2010clamp recordings indicated that pyramidal neurons provide intracortical glutamatergic inputs onto IS interneurons. Most connections had high probabilities of response and exhibited frequency\u2010dependent paired pulse depression. Comparison of the amplitude distribution of paired responses suggested that most of these connections consisted of multiple functional release sites. Finally, two discrete subpopulations of IS cells could be identified based on the duration of the initial burst of action potentials and the differential expression of calretinin and choline acetyltransferase.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":9743930,"openaccessinfo":{"externalids":{"MAG":"2113257084","ACL":null,"DOI":"10.1046\/j.1460-9568.1998.00367.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"www.sciencemag.org (this information is current as of September 1, 2007 ): The following resources related to this article are available online at http:\/\/www.sciencemag.org\/cgi\/content\/full\/310\/5745\/116 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http:\/\/www.sciencemag.org\/cgi\/content\/full\/310\/5745\/116\/DC1 can be found at: Supporting Online Material http:\/\/www.sciencemag.org\/cgi\/content\/full\/310\/5745\/116#otherarticles , 4 of which can be accessed for free: cites 13 articles This article 2 article(s) on the ISI Web of Science. cited by This article has been http:\/\/www.sciencemag.org\/cgi\/content\/full\/310\/5745\/116#otherarticles 1 articles hosted by HighWire Press; see: cited by This article has been http:\/\/www.sciencemag.org\/cgi\/collection\/neuroscience Neuroscience : subject collections This article appears in the following http:\/\/www.sciencemag.org\/about\/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":198167455,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Graphene-based materials have strong cytotoxic attributes against bacteria due to their unique physicochemical properties. We examined the antibacterial activities of nanosheets of the graphene analogue tungsten disulphide (WS2) and a composite of reduced graphene oxide-tungsten disulphide (rGO-WS2), comparing them with reduced graphene oxide (rGO) by a time and concentration dependent viability assay and growth curve studies against four bacterial strains: Gram negative Escherichia coli (E. coli) and Salmonella typhimurium (S. typhimurium), and Gram positive Bacillus subtilis (B. subtilis) and Staphylococcus epidermidis (S. epidermidis). The nanosheets of the rGO-WS2 composite caused a more significant retardation in bacterial growth and inhibitory effect on the tested bacterial strains than WS2, followed by rGO. The tested E. coli and B. subtilis strains were more susceptible than the other strains. A mechanistic study revealed that rGO and WS2 did not produce the superoxide anion (O2\u02d9\u2212) or reactive oxygen species (ROS), but the nanocomposite of rGO-WS2 did produce both. However, all these materials did oxidize glutathione, which serves as a redox state mediator in bacteria. We conclude that the antimicrobial mechanism is due to the combined effect of initial cell deposition on the rGO-WS2 materials, the membrane stress due to direct contact with the nanosheets, and the produced superoxide anion-independent oxidation mechanisms. The beneficial aspects of the physicochemical properties of rGO-WS2, such as its size and conductivity, can be precisely customized to reduce its health and environmental risk factors.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":83512799,"openaccessinfo":{"externalids":{"MAG":"1783576552","ACL":null,"DOI":"10.1039\/C5RA15652A","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Worldwide, many production supply chains generate a considerable amount of legume by-products (e.g., leaves, husks, broken seeds, defatted cakes). These wastes can be revalorized to develop sustainable protein ingredients, with positive economic and environmental effects. To separate protein from legume by-products, a broad spectrum of conventional (e.g., alkaline solubilization, isoelectric precipitation, membrane filtration) and novel methodologies (e.g., ultrasound, high-pressure homogenization, enzymatic approaches) have been studied. In this review, these techniques and their efficiency are discussed in detail. The present paper also provides an overview of the nutritional and functional characteristics of proteins extracted from legume by-products. Moreover, existing challenges and limitations associated with the valorization of by-product proteins are highlighted, and future perspectives are proposed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257362846,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/10408398.2023.2184322","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"People with higher levels of physical activity report enhanced mental health (Law et al. 2014). In contrast, low levels of exercise can in turn lead to waning of physical and mental health, along with a decreased social network, as sedentary behaviours become the norm (Valencia, Stoutenberg & Florez, 2014). This is particularly so in older people.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":59567320,"openaccessinfo":{"externalids":{"MAG":"2908456239","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Blood transfusions are given for acute and chronic illness including cardiothoracic surgery, acute stabilization, and chronic transfusion therapy (CTT) in patients with thalassemia and sickle cell disease (SCD). Increased age of stored red blood cells and the associated storage lesion has been implicated in poor cardiovascular outcomes, increased length of ICU stay, multiorgan failure and increased use of inotropes after cardiac surgery. Red cell aging, during storage, is thought to alter the metabolic profile of the red cell in a manner that causes decreased nitric oxide bioavailability. Aged red cells demonstrate vasoinhibitory activity of aortic ring preparations. S-nitrosohemoglobin is decreased in stored blood but when replete, tissue oxygen delivery and renal damage were ameliorated in an animal blood loss model. We aimed to determine whether the age of the stored blood relates to vascular function in-vivo, using a population of chronically transfused patients with SCD.\n\nWe did prospective study to examine transfusion effects on vascular function, in which we enrolled 26 patients with SCD on CTT and tested flow mediated dilation (FMD) of the brachial artery, cardiac output and blood viscosity changes with transfusion. We measured both oxygenated and deoxygenated whole blood viscosity at shear rates from 1s-1 to 1000s-1 at native hematocrit using a Rheolog viscometer (Rheologics Co). We also obtained pre and post transfusion measures of cardiac output, flow mediated dilation of the brachial artery, blood counts, chemistry panels, markers of inflammation and hemolysis.\n\n14 females and 12 males were enrolled. The ages and reasons for starting transfusions were similar for male and female patients. As expected, transfusion resulted in significant increases of hemoglobin and hematocrit (hct) with concomitant decrease of hemoglobin S% (HbS%) and reticulocyte count. Male patients had a significantly higher HbS%, reticulocyte count, plasma free hemoglobin and platelet count compared to females. Viscosity increased significantly across all shear rates with transfusion and with deoxygenation. There was no sex difference in viscosity. FMD was significantly improved following transfusion with an average increase of 1.4% (P=0.01). By univariate analysis, elevated body mass index (BMI), small change in hematocrit to viscosity ratio (HVR) at 2s-1 (low shear), and the lower age of the stored blood were significantly associated with improved FMD. By multivariate analysis, using only two variables at a time due to small sample size, elevated BMI was the best predictor of improved FMD. ([Figure 1][1]) There was a confounding effect between the age of the blood and BMI in our study; there was a negative correlation between age of the blood given and BMI, whereby smaller patients received older blood in our cohort.(R2 0.20, P=0.03). BMI did not correlate with pre-transfusion FMD.\n\n![Figure 1][2] \n\nFigure 1 \n\nMost patients with SCD on CTT had improved FMD following transfusion and given the dependence of FMD on shear stress, changes in rheologic factors such as viscosity and hematocrit would be expected to cause significant changes in FMD. The increase in hct, and viscosity and the decrease in HbS% did not correlate with improvement in FMD. Decrease in low shear HVR did correlate with improved FMD, however, FMD is thought to correlate with higher shear rates, whereas the HVR at low shear rate would be found in the venous system. This could provide a link between endothelial function and the low shear venous system, particularly due to its FMD correlation with \"deoxygenated\" HVR. BMI and age of the stored red cells correlated whereby our smaller patients received older blood resulting in confounding between these variables. Despite the confounding effect, when blood age was locked in the model, BMI still exerts an independent effect on FMD. Whether the effect of BMI is chronic or acute could not be determined in our study; however, nutritional factors, adipose tissue and hormones might play a role in the set point of FMD via eNOS expression in the endothelium. Older blood age was associated with worsening FMD, which is consistent with decreased nitric oxide bioavailability as a piece of the red cell storage lesion puzzle. Future studies should attempt to control for BMI and blood age to minimize confounding effects.\n\nDisclosures: Coates: Novartis Inc.: Honoraria, Speakers Bureau; Apopharma: Honoraria, Speakers Bureau; Shire: Speakers Bureau. Wood: Shire: Consultancy, Research Funding; Apopharma: Honoraria, Patents & Royalties; Novartis: Honoraria.\n\n [1]: #F1\n [2]: pending:yes","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":77683856,"openaccessinfo":{"externalids":{"MAG":"2464819592","ACL":null,"DOI":"10.1182\/BLOOD.V122.21.3653.3653","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the Top Right Access point Minimum Length Corridor (TRA-MLC) problem [1], a rectangular boundary partitioned into rectilinear polygons is given and the problem is to find a corridor of least total length and it must include the top right corner of the outer rectangular boundary. A corridor is a tree containing a set of line segments lying along the outer rectangular boundary and\/or on the boundary of the rectilinear polygons. The corridor must contain at least one point from the boundaries of the outer rectangle and also the rectilinear polygons. Gutierrez and Gonzalez [1] proved that the MLC problem, along with some of its restricted versions and variants, are NP-complete. In this paper, we give a shorter proof of NP-Completeness of TRA-MLC by findig the reduction in the following way. Connected vertex cover in 2-connected planar graph with maximum degree 4 \u2193 Top-Right Access Point Minimum Length Corridor ( TRA-MLC) Keywords\u2014NP-complete, 2-Connected planar graph, Grid embedding of a plane graph.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251392722,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"CAPTCHAs, also known as reverse Turing tests are real-time assessments that are commonly used by programs to tell humans and machines apart. This can be achieved by assigning and assessing or evaluating hard AI problems such that these problems could only be solved easily by human but not by machines. A new security approach based on hard AI problems and Captcha technology is known as Captcha as gRaphical Passwords (CaRP). This scheme can address many security problems such as dictionary attacks, online guessing attacks and shoulder-surfing attacks etc. In this paper, we present an enhanced security for the CaRP scheme i,e CaRP with motion-based Captcha. The motion can be done by using video. The movement of Captcha ensures high security over the normal CaRP scheme. Video-based captcha can provide a great challenge for humans in exploiting the remarkable perceptual abilities or skills of humans to unravel structure-from-motion. The scheme can resist attack caused due to moving object detection. Thus it can thwart many attacks, can enforce more security and it stipulates security along with usability to legitimate users in dealing with real time applications.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":15067123,"openaccessinfo":{"externalids":{"MAG":"2555561713","ACL":null,"DOI":"10.1109\/ICATCCT.2015.7456884","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Swallowing dysfunction, or dysphagia, is a serious condition that can result from any structural or neurological impairment (such as stroke, neurodegenerative disease or brain injury) that affects the swallowing mechanism. The gold-standard method of instrumental swallowing assessment is an x-ray examination known as the videofluoroscopic swallowing study, which involves radiation exposure. Consequently, there is interest in exploring the potential of less invasive methods, with lesser risks of biohazard, to accurately detect swallowing abnormalities. Accelerometry is one such technique, which measures the epidermal vibration signals on a patient's neck during swallowing. Determining the utility of accelerometry signals for detecting dysphagia requires an understanding of the physiological source of the vibrations that are measured on the neck during swallowing. The purpose of the current study was to determine the extent to which movement of the hyoid bone and larynx contributes to the vibration signal that is registered during swallowing accelerometry. This question was explored by mapping the movement trajectories of the hyoid bone and the arytenoid cartilages from lateral videofluoroscopy recordings collected during thin liquid swallowing, and comparing these trajectories to time-linked signals obtained from a dual-axis accelerometer placed on the neck, just anterior to the cricoid cartilage. Participants for this study included 43 adult patients referred for videofluoroscopic swallowing studies to characterize the nature and severity of suspected neurogenic dysphagia. A software program was created to allow frame-by-frame tracking of structural movement on the videofluoroscopy recordings. These movement data were then compared to the integrated acceleration data using multiple linear regressions. The results concur with previous studies, implicating hyolaryngeal excursion as the primary physiological source of swallowing accelerometry signals, with both the hyoid and the larynx contributing approximately equal amounts to the explained variance of the dependent variable, the integrated accelerometry signal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32671965,"openaccessinfo":{"externalids":{"MAG":"2049019911","ACL":null,"DOI":"10.1088\/0967-3334\/31\/6\/008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract The relation between Sir Walter Scott and Scotland is that of the hen and the egg: we can never be sure what came first and who authored whom. Such paradoxes are typical also of the ways in which Scott's authorship and anonymity are entangled with one another. After a general reflection on how authorship may feature as anonymity and vice versa, this article turns to some of Scott's autobiographical documents which consider physical illness and anonymity not as handicaps but as empowering to his writing. Scott's novel Redgauntlet is autobiographical precisely in that it echoes these correlations of illness, incognito and authorship. Especially through his indebtedness to Scottish legends and (anonymous) oral performance, the case of Walter Scott encourages us to imagine alternative models of authorship which simultaneously undermine and supplement Roland Barthes' manifesto of \"The Death of the Author.\"","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":164069950,"openaccessinfo":{"externalids":{"MAG":"2328979700","ACL":null,"DOI":"10.1515\/zaa.2011.59.3.227","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The composites between the reinforced glass fibre wastes obtained from surfboard manufacturing industry and polypropylene were developed for value adding and environmental reasons. The thermomechanical and rheological behaviours of the composites were investigated. Glass fibre contents were varied from 5 to 30wt%. The effects of maleic anhydride grafted polypropylene (MA-PP) compatibilizer on the behaviours were also determined. The results revealed that the addition of glass fibre was able to reduce the heat of fusion of the composite. Additionally, the tensile and flexural properties were increased with increasing the glass fibre contents following the rule of mixtures. The addition of MA-PP led to enhance tensile and flexural properties due to the improvement of the adhesion between matrix and glass fibre, which is correlated with morphological observations. From the rheological studies, the apparent flow activation energy revealed that the addition of glass fibre decreased the fluidity of the molten composite materials; however, it could be slightly improved by using MA-PP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210772260,"openaccessinfo":{"externalids":{"MAG":"2741952857","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this thesis some new aspects of the infection process of nonenveloped viruses are reported. The interaction of a rod-shaped (TMV) and three spherical (CCMV, BMV, SBMV) plant viruses, of the filamentous bacteriophage M13, and of their coat proteins with membranes have been investigated. A comparison is made between the infection mechanisms of these non-enveloped viruses. 1 EFFECT OF PLANT VIRUSES ON MEMBRANES All plant viruses studied interact with membranes. This is demonstrated by turbidity measurements of small unilamellar vesicles with different surface charges (chapter 2). The interaction is either electrostatic or hydrophobic. Neutral vesicles always interact with viral capsids by indirect hydrophobic interaction. On the other hand, charged vesicles always interact with opposite charges at the capsids by electrostatic interaction. The location of the coat protein after interaction has been determined to test Durham's model for plant virus infection, in which the coat protein becomes an integral membrane protein, similarly as for M13 infection. The results indicate that as a result of the interactions, multilamellar vesicles are formed, containing all the protein in case of electrostatic interaction. The coat protein is associated at the bilayer surface. However, after hydrophobic interaction no protein is found in the multilamellar vesicles. For the latter type of interaction a mechanism is proposed, in which the coat protein behaves as a catalyst, only enhancing the rate of fusion and multilamellar vesicle formation. Since in either case no lipid-protein complex is formed, that is stabilized by direct hydrophobic lipid-protein interactions, Durham's model for plant virus infection is very likely to be incorrect. The recently proposed co-translational disassembly model for plant virus infection, in which the viral particle dissociates during translation of its RNA by the host ribosomes, does not include a specific role for membranes during disassembly. However, before the co-translational disassembly takes place, the particles need to be destabilized. At this moment no specific mechanism for this process has been proposed. Also the fate of the coat protein after particle disassembly remains unspecified in any model, with exception of Durham's model. The observed electrostatic interaction at the bilayer surface (e.g. with the N-terminal arm of the coat proteins, released upon assembly may play a significant role in the infection mechanism. From the experiments described in this thesis no results contradictory to co-translational disassembly have been found. Therefore, to our present opinion, the best model for plant virus infection is the co-translational disassembly model. In this view it is assumed implicitely that the virus particles arrive intact in the cytoplasm, for example by passage through the cell wall and the plasma membrane by local, transient wounding. 2 EFFECT OF THE MEMBRANE ON BACTERIOPHAGE M13 COAT PROTEIN M13 coat protein has been incorporated as an intrinsic protein in micelles and model membranes (chapter 3-4). The secondary structure of coat protein in SDS micelles is, predominantly \u03b1-helix (60%), while in membranes (DMPC\/DMPA 80\/20 w\/w) the structure is entirely \u03b2-structure. In micelles at high detergent protein ratio the protein is dimeric with the central core in \u03b2-structure. The termini of the coat protein (30 residues or 60%) are in \u03b1-helix structure. The dynamics of the micellar system, investigated by time-resolved fluorescence anisotropy measurements, is characterized by rotation of the complex on the nanosecond timescale (10 ns at 20\u00b0C) and additional mobility of the Trp-26 sidechain on the subnanosecond timescale (0.5 ns). The complex has a temperature dependent overall rotation, that satisfies the Stokes-Einstein relation for spherical rotation. From this dependence it has been determined that the complex consists of two coat protein molecules and approximately 57 SDS molecules. In membranes, regardless of the lipid to protein ratio, the coat protein Is aggregated. This is concluded from three independent measurements. Fluorescence anisotropy decay measurements indicate that the single tryptophan-26 in the hydrophobic core is highly ordered on the nanosecond timescale in liquid-crystalline bilayers, whereas the surrounding lipids are not. 2 H NMR measurements indicate that all the exchangeable sites at the backbone are ordered on the microsecond timescale. Both results are consistent with protein aggregation. Finally, the fraction of motionally restricted lipid, determined from spin label ESR is too low for a monomeric state of the coat protein in the membrane, also in agreement with protein aggregation. The state of the M13 coat protein in model membranes used in the experiments of this thesis is therefore best described as a \u03b2- polymeric state. Within the polymer the orientation of the coat protein is unknown. For comparison, in vivo , the coat protein in the E . coli cytoplasmic membrane is known to be oriented. Its secondary structure and state of aggregation, however, are up to now unknown. 3 EFFECT OF BACTERIOPHAGE M13 COAT PROTEIN ON THE MEMBRANE In model membranes also the effect of M13 coat protein incorporation on the lipids has been investigated (chapter 4). Upon introduction of coat protein in the membrane as an intrinsic protein a fraction of the lipid molecules becomes motionally restricted. The spin labelled phospholipids show a difference in their selectivity for the coat protein: cardiolipin = phosphatidic acid>>stearic acid phosphatidylserine = phosphatidylglycerol>>phosphatidylcholine phosphatidylethanolamine. The selectivities found are related to the composition of the target E . coli cytoplasmic membrane. Typically, neutral phosphatidylethanolamine accounts for 74% of the lipid in the membrane, constituting the bulk of the lipid, while phosphatidylglycerol is present for 19% and cardiolipin for 3%. The high selectivity of cardiolipin for the coat protein forms direct, biophysical evidence for a previously suggested molecular association of cardiolipin with the coat protein. This was concluded from an increase in the cardiolipin synthesis after infection of E . coli by M13. No increase in phosphatidylglycerol synthesis, the major negatively charged lipid, is observed after infection. Using selectively deuterated palmitic acid as probe lipid, spectral broadening has been observed in presence of M13 coat protein. This result, as well as the ESR results, agrees with a two-site exchange model for the probe lipid between sites in the bulk of the membrane and motionally-restricted sites at the protein. The exchange rate is fast on the nanosecond timescale of the ESR technique, but slow on the microsecond timescale of the 2H NMR technique. The exchange rate of 10 +7 Hz, deduced from simulation of the spin label ESR spectra, is in excellent agreement with these upper and lower limits.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97918129,"openaccessinfo":{"externalids":{"MAG":"2117458082","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Good Night Project is an evidence-based project aimed to design, implement and evaluate an RCT of behavioural interventions to improve sleep for children aged 5-12 years with ADHD and their primary caregivers in the Kingdom Saudi Arabia. The project was developed by systematically reviewing the literature. From the available, high quality literature using an RCT design (n=4), a group of behavioural interventions were identified using the behaviour change techniques taxonomy BCTs (Chapter two). Health professionals and caregivers were asked to rank these interventions from the most important interventions to the less important interventions using a Delphi method in two rounds (Chapter three). Their recommendations were considered when preparing the final version of the intervention. The 34-page Good Night Project was developed as a guide, translated from English to Arabic. Sleep habits cards and a video clip were also available to help children and their caregivers to promote sleep hygiene. The intervention, using these materials, was delivered by the psychologists to the caregivers in three sessions over three weeks, with each session lasting for three hours. The project was completed in the Kingdom of Saudi Arabia using a randomised controlled trial (RCT) design (Chapter four). Due to the high attrition rate, the number of participants who dropped out (n=61) which is more than 80% of the eligible participants, the study aim has been changed to examine the feasibility of the project instead of the efficacy (Chapter four). The results indicated that the Good Night Project is not feasible at this stage due to high attrition rate, although there is some tentative evidence of positive outcomes for those who completed the intervention. Thus, a further study is required using focus groups or experience-based co-design in order to explore factors that affect parents' ability to complete the \nintervention. Following this, a further feasibility study is recommended taking into account the changes indicated to improve acceptability. General discussion about the project including summary of the results, implication for practice and for future research and contribution to knowledge including behavioural change interventions, culturally adapting interventions and sleep in children with ADHD are considered (Chapter five).","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":80863735,"openaccessinfo":{"externalids":{"MAG":"2901982222","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract This article formulates an empirical model that measures the short- and long-run effects of political stability, corruption control and economic growth on CO2 emissions from deforestation. Political stability and corruption have significant effects on forest cover in the short run and have lingering long-run effects. We derive a U-shaped forest\u2013income curve where forest cover initially declines as per capita income increases, but starts to rise after an income turning point. Political stability and corruption control do not significantly affect the income turning point but both variables shift the forest\u2013income curve up or down. The resulting CO2 emission\u2013income curve is downward sloping and is based on changes in the levels of variables affecting forest cover. Increased political stability flattens the CO2 emissions\u2013income curve, leading to smaller changes of CO2 emissions per unit change in income.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":154922974,"openaccessinfo":{"externalids":{"MAG":"2091266279","ACL":null,"DOI":"10.1017\/S1355770X11000222","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Distyryl-oligothiophenes (DS-nT) is one of the promising semiconducting materials that use for organic thin-film transistors (OTFTs). The in-plane structures of vapor deposited ultrathin films of DS-4T, and its derivatives with different end-cap groups, on SiO2substrate were characterized by grazing incidence x-ray diffractometry (GIXD). The morphology and film structure change with the nature of end-cap groups. The increase in volume of end-cap group causes the decrease in crystallinity and increase in frequency in nucleation. These characteristics could affect to the transport properties in OTFTs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":97167209,"openaccessinfo":{"externalids":{"MAG":"2043150956","ACL":null,"DOI":"10.1088\/1742-6596\/83\/1\/012026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION: There are no conclusive data to support the superior efficacy of any one antidepressant, while costs and side-effects are known to differ. The use of venlafaxine has been observed to be increasing within local services and this is associated with significant cost. This survey examined the patterns of use of new antidepressants by psychiatrists in the UK. METHOD: 188 questionnaires were sent to hospital pharmacists. The doses of fluoxetine, paroxetine, sertraline and venlafaxine used for the treatment of depression over a 1-week census period were recorded, together with the total quantities of each drug supplied by hospital pharmacies in the financial year 1997\/1998. RESULTS: 84 completed replies were received (45%), with a total number of 2060 prescriptions for depression, making this the largest survey to date of antidepressant prescribing by psychiatrists. Fluoxetine and paroxetine were associated with less dosage titration and cost less per treatment month than sertraline and venlafaxine. CONCLUSION: Venlafaxine has not been consistently proven to be more effective than other antidepressants and is more costly, yet its use by psychiatrists is increasing nationally. Comparative data such as these are not routinely available for hospital care in the UK. The new NHS will bring more demand for such data and more accountability for its content. (Int J Psych Clin Pract 2000; 4:105-109)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5568027,"openaccessinfo":{"externalids":{"MAG":"2113807799","ACL":null,"DOI":"10.1080\/13651500050518253","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"AIM\nThe prevalence of metabolic syndrome (MetS) increases even in adolescents. The evidence that MetS is associated with the periodontal diseases in adolescents has been understudied. Therefore, our aim was to assess the association between MetS parameters and gingivitis in adolescents.\n\n\nMATERIAL AND METHODS\nA total of 941 participants (590 boys, 351 girls), aged 12-18 years was selected from the Fourth Korea National Health and Nutrition Examination Survey, a cross-sectional and nationally representative survey, which had had information on waist circumference, blood pressure, serum triglyceride, high-density lipoprotein (HDL) cholesterol, and the fasting blood sugar and community periodontal Index (CPI).\n\n\nRESULTS\nThe number of positive parameters of MetS showed significant positive correlation with gingivitis; adjusted and crude ORs with one positive parameters of MetS were 1.92 (95% CI: 1.21-3.04) and 1.88(95% CI: 1.28-2.76), respectively. And adjusted OR with three or more positive parameters of MetS was 3.29 (95% CI: 1.24-8.71). Among five parameters of MetS, Low HDL-cholesterol showed significant association with gingivitis (crude OR 2.12, 95% CI 1.20-3.73; adjusted OR 1.96, 95% CI 1.24-3.12).\n\n\nCONCLUSIONS\nHaving more positive parameters of MetS and low HDL-cholesterol parameter had an independent relationship with the prevalence of gingivitis, which may be determinants for the future periodontal diseases even in adolescents.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2800398,"openaccessinfo":{"externalids":{"MAG":"1970900793","ACL":null,"DOI":"10.1111\/jcpe.12338","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/jcpe.12338","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In order to establish more accurate nuclear data for the yttrium isotope 89Y, joint experimental work has been conducted in four greatly different thermal-to-epithermal neutron flux ratios (Qth\/Qepi). After carefully calibrating the neutron spectra in the irradiation channels used, nuclear constant K0, Ke,0 and Q0 remeasured and found to be: for E=202.5 keV K0=2.33\u00d710-5 (1.9%), K0 according to the Cd-subtraction method=2.31\u00d710-5 (1.7%) and Ke,0=8.76\u00d710-6 (2%) for E=479.5 keV K0=2.19\u00d710-5 (2%), K0 according to the Cd-subtraction method=2.18\u00d710-5 (1.9%), and Ke,0=8.30\u00d710-6 (2%) and Q0=6.20 (2.1%). The relevant effective resonance energies \u0112r have been recalculated using the latest BNL neutron resonance parameters yielding \u0112;r (89Y)=4302 eV (7%). The half life of the 90mY isotope has also been remeasured to give T1\/2 (90mY)=3.185 h (0.5%) with 1\u03c3 limit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":94069482,"openaccessinfo":{"externalids":{"MAG":"1973517831","ACL":null,"DOI":"10.1143\/JJAP.31.3461","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This overview aims to create an understanding of the nutritional issues concerning patients with cancer and provide evidence-based practical guidance to healthcare professionals (physicians, nurses, and dietitians), caregivers, and all others involved in the care of patients with cancer. The focus of this paper is therefore on providing a simple guide for daily clinical practice. The theoretical background and in-depth comprehensive reviews of malnutrition are described elsewhere. Nutrition plays a crucial role in cancer care. It affects treatment tolerability, outcomes, and quality of life. However, a focus on nutrition is still lacking among oncologists because of insufficient training in nutrition topics received during graduate and postgraduate training and an underestimation of its importance. The consequences of the disease and its treatment, such as anorexia-sarcopenia-cachexia, are therefore still often overlooked, underdiagnosed, and undertreated. The authors have summarized the most important challenges, evidence-based recommendations, and common clinical scenarios to bridge the gap between comprehensive guidelines and clinical practice, where brief concrete advice is preferred to systematic reviews. Furthermore, an easy applicable overview is provided, which can be used as a guide during daily routines.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":231611903,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1200\/OP.20.00704","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A new method for measuring optical-beat frequencies in the terahertz (THz) region using microwave higher harmonics is presented. A microwave signal was applied to the antenna gap of a photoconductive (PC) device emitting a continuous electromagnetic wave at about 1 THz by the photomixing technique. The microwave higher harmonics with THz frequencies are generated in the PC device owing to the nonlinearity of the biased photoconductance, which is briefly described in this article. Thirteen nearly periodic peaks in the photocurrent were observed when the microwave was swept from 16 to 20 GHz at a power of -48 dBm. The nearly periodic peaks are generated by the homodyne detection of the optical beat with the microwave higher harmonics when the frequency of the harmonics coincides with the optical-beat frequency. Each peak frequency and its peak width were determined by fitting a Gaussian function, and the order of microwave harmonics was determined using a coarse (i.e., lower resolution) measurement of the optical-beat frequency. By applying the Kalman algorithm to the peak frequencies of the higher harmonics and their standard deviations, the optical-beat frequency near 1 THz was estimated to be 1029.81 GHz with the standard deviation of 0.82 GHz. The proposed method is applicable to a conventional THz-wave generator with a photomixer.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7303156,"openaccessinfo":{"externalids":{"MAG":"2040403875","ACL":null,"DOI":"10.1063\/1.3589859","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The behavior of two unidirectionally coupled chaotic oscillators near the generalized synchronization onset has been considered. The character of the boundaries of the generalized synchronization regime has been explained by means of the modified system approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16412846,"openaccessinfo":{"externalids":{"MAG":"2012249519","ACL":null,"DOI":"10.1209\/epl\/i2005-10343-4","PubMedCentral":null,"ArXiv":"nlin\/0512044"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/nlin\/0512044","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The paper outlines some trends in current frameworks of undergraduate (UG) academic programs, necessitating a fresh look into many local higher education institutions (HEIs) curricula with improvements and reforms in mind. An attempt is made to establish a link between national qualifications frameworks (NQFs) and academic accreditation standards to guide in the process. Focus is on two currently common issues : first, the role of NQFs and second, the adoption of specialization streams in the structure of UG program curricula.\u00a0 Particular attention is given to revising curricula to include the general education (GE) and the concentration components, within outcome-based education (OBE) environments, in a systematic manner as a way of meeting the demands. Model frameworks that may be adapted for UG programs are proposed based on current practices in many established and accredited UG program curricula to illustrate the intents.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":116056337,"openaccessinfo":{"externalids":{"MAG":"2889280904","ACL":null,"DOI":"10.25007\/AJNU.V7N3A229","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report a case of vagally mediated atrial fibrillation on a young otherwise healthy man, with straight type ST-segment elevation in inferolateral leads that resolved a few hours after restoration of sinus rythm, a phenomenon that has never been previously reported. Even though no definite conclusion about the underlying mechanism of the ST-elevation can be made, this effect might probably be the result of intense parasympathetic tone and could be used to differentiate the causality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22958237,"openaccessinfo":{"externalids":{"MAG":"2187806229","ACL":null,"DOI":"10.4022\/jafib.487","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo evaluate the clinical effects of iliolumbar fixation for the sacrum fractures of Denis type II.\n\n\nMETHODS\nThe clinical data of 86 patients with sacrum fracture of Denis type II treated by iliolumbar fixation from January 2008 to January 2012 were retrospectively analyzed. There were 55 males and 31 females, aged from 17 to 55 years old with an average of 39.1 years. Among them, 73 cases complicated with pelvis fracture and 13 cases with acetabular fracture; 37 cases with sacral neurological symptoms and 49 cases without sacral neurological symptoms. Fracture healing time, nerve function, clinical function and complications were observed in the patients.\n\n\nRESULTS\nIn 86 cases, 6 cases were out of followed-up and 80 cases were followed up from 24 to 71 months with an average of 36 months. The mean fracture healing time was 13 weeks (ranged, 10 to 38 weeks). According to Gibbons scoring to evaluate the neurological function, preoperative nerve rehabilitation, lower limbs feeling, lower limbs activity,bladder and rectum function,total score respectively were 0.62 +\/- 0.04, 1.54 +\/- 0.35, 1.12 +\/- 0.18, 0.23 +\/- 0.01, 3.46 +\/- 0.47 and postoperative respectively were 0.82 +\/- 0.12, 0.36 +\/- 0.04, 0.05 +\/- 0.01, 0.03 +\/- 0.01, 1.25 +\/- 0.22, there were statistically significant differences between preoperative and postoperative (P < 0.05). According to Majeed scoring to evaluate the clinical function, postoperative pain, standing, sitting, sexual life, work ability, total score respectively were 22.54 +\/- 4.02, 27.93 +\/- 5.46, 8.47 +\/- 3.61, 2.54 +\/- 1.33, 16.46 +\/- 4.34, 81.32 +\/- 8.73, 60 cases got excellent results, 17 good, 3 fair. The main complications including fracture nonunion of 5 cases,deep incision infection of 1 case, and screw prominence resulting uncomfortable of 8 cases.\n\n\nCONCLUSION\nIliolumbar fixation has the advantages of stable fixation, satisfactory functional rehabilitation, less complications, and is a good method in treating sacrum fracture of Denis type II.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38123139,"openaccessinfo":{"externalids":{"MAG":"2345330946","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The resonance character of Cu\/Ag\/Au bonding is investigated in B\u22c5\u22c5\u22c5M-X (M=Cu, Ag, Au; X=F, Cl, Br, CH3, CF3; B=CO, H2O, H2S, C2H2, C2H4) complexes. The natural bond orbital\/natural resonance theory results strongly support the general resonance-type three-center\/four-electron (3c\/4e) picture of Cu\/Ag\/Au bonding, B:M-X\u2194B(+) -M:X(-) , which mainly arises from hyperconjugation interactions. On the basis of such resonance-type bonding mechanisms, the ligand effects in the more strongly bound OC\u22c5\u22c5\u22c5M-X series are analyzed, and distinct competition between CO and the axial ligand X is observed. This competitive bonding picture directly explains why CO in OC\u22c5\u22c5\u22c5Au-CF3 can be readily replaced by a number of other ligands. Additionally, conservation of the bond order indicates that the idealized relationship bB\u22c5\u22c5\u22c5M +bMX =1 should be suitably generalized for intermolecular bonding, especially if there is additional partial multiple bonding at one end of the 3c\/4e hyperbonded triad.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205703284,"openaccessinfo":{"externalids":{"MAG":"2098619408","ACL":null,"DOI":"10.1002\/cphc.201500211","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract : The Integrated Survivability System Integration Laboratory (ISSIL) developed at the U.S. Army Tank-Automotive Research, Development, and Engineering Command (TARDEC) is a tool which enables and enhances the integration of Soldier survivability technology suites. TARDEC utilized the ISSIL to bridge the gap between concept and realization of the survivability demonstrator vehicle built on MTV 1083 A1P2 platform. The ISSIL was a critical tool for enabling the integration of mechanical, electrical, data, and networking components as well as for validating the system integration through Soldier usability trials. This paper describes how the ISSIL advanced the RDECOMs comprehensive systems engineering process throughout the modeling, analysis, design, development and testing of the demonstrator vehicle.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":12199953,"openaccessinfo":{"externalids":{"MAG":"229119946","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The issue of safety standards for new drugs remains unsettled. Limitations of biomarker or observational studies for assessing global safety and efficacy of postmenopausal hormone therapy are highlighted by contrast with randomized clinical trial results. On the other hand, requiring large-scale, long-term outcome trials for every new drug might not be practical. Randomized trials with intermediate outcomes such as coronary angiography, coronary or carotid ultrasound, or coronary calcification present attractive alternatives. Trials with intermediate outcomes can be conducted with much smaller sample sizes and shorter duration, but the adequacy of these types of trials for assessment of safety and efficacy remains a topic of ongoing discussion in the scientific and regulatory communities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38338400,"openaccessinfo":{"externalids":{"MAG":"2081149024","ACL":null,"DOI":"10.3816\/CBC.2006.S.006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Primary ankle arthrodesis used to treat a neglected open ankle fracture dislocation is a unique decision. A\u00a063-year-old man presented to the emergency department with a 5-day-old open fracture dislocation of his\u00a0right ankle. After thorough soft tissue debridement, primary arthrodesis of the tibiotalar joint was performed using initial Kirschner wire fixation and an external fixator. Definitive soft tissue coverage was later achieved using a latissimus dorsi free flap. The fusion was consolidated to salvage the limb from amputation. The use of primary arthrodesis to treat a compound ankle fracture dislocation has not been previously described.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31578804,"openaccessinfo":{"externalids":{"MAG":"1970258226","ACL":null,"DOI":"10.1053\/j.jfas.2013.09.013","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"PurposeConstruction manufacturers predominantly rely upon antiquated manual design and production processes and procedures because they lack technical skills needed to automate working practices. This paper aims to automate manufacturing processes by optimising the utilisation of BIM digital objects (BDO) via the development of a conceptual model. Concomitant objectives seek to reduce design errors; eliminate unnecessary costs; automate the generation of quantity bills; and maximise productivity performance.Design\/methodology\/approachAn inductive approach was adopted through a post positivist epistemological lens set within the context of a case study of a small- and medium-sized enterprise. From an operational perspective, both qualitative and quantitative data were collected and analysed via a novel four-phase waterfall design, namely, literature diagnosis; recording contemporary practice; mapping manufacturing workflow and procedures; and evaluation and proof of concept development.FindingsThe work illustrates that BDO enhances manufacturing workflow, reduces product manufacturing lead time and augments quality assurance throughout the whole life cycle of a manufactured product. The conceptual model developed provides a pragmatic and comprehensive solution to automate construction manufacturing procedures and to improve the facilitation of information exchanged between all stakeholders involved.Originality\/valueThis study presents the first comprehensive case study of BDO application within a manufacturing context. Future research is however, needed to test and validate the conceptual model presented in practice. In doing so, the model can be further refined using practitioner input and real-life manufacturing processes and procedures.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":203084937,"openaccessinfo":{"externalids":{"MAG":"2972180049","ACL":null,"DOI":"10.1108\/jedt-03-2019-0065","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.open-access.bcu.ac.uk\/9408\/1\/Conceptualising_Submitted%2011_3_19.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT This paper explores the use of combination of flexible alternating current transmission system (FACTS) devices, demand response (DR) programs, and generation redispatch (GR) in short-term congestion management as well as minimization of operation costs under contingency conditions in power systems. To achieve this, a multi-stage market clearing procedure is formulated. At the first stage, the market is cleared based on generation cost minimization, without considering network constraints. Market clearing formulation for the second stage is developed considering congestion and generation costs, in which FACTS device (Thyristor Controlled Series Capacitor) and DR programs (Direct Load Control besides Time-Of-Use) are optimally coordinated with GR in the presence of network constrains, to manage the congestion at minimum costs. In addition, to make conditions more realistic, the operational conditions spanning for a year (four seasons, day by day) are considered in this study. Finally, the paper prioritizes utilizing these approaches for different contingencies. The proposed formulation is verified on IEEE 14-bus and IEEE 30-bus test systems with supporting numerical and graphical results. Results show that applying GR with DR programs is the prioritized strategy in relieving congestion and reducing generation costs in the outage of the most sensitive lines contingency.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":125850544,"openaccessinfo":{"externalids":{"MAG":"2553055966","ACL":null,"DOI":"10.1080\/03772063.2016.1242380","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\n: Multiple subpial transection (MST) is a potential surgical treatment for patients with epileptogenic foci located in cortical areas with higher functions. As neurosurgical teams have become more experienced with MST, the original technique has adapted.\n\n\nOBJECTIVE\n: To report our 6-year experience with a modified MST technique.\n\n\nMETHODS\n: The population included 62 consecutive patients with medically refractory epilepsy treated by MST, with a follow-up period ranging from 2 to 9 years. MST was performed on gyri under neuronavigation and guided by intraoperative electrocorticography. We performed radiating MST from a single cortical entry point. The MST technique was described according to the number of transections performed and the Brodmann areas (BAs) involved. Any MST-related complications were registered and followed up. Clinical outcome was described in terms of seizure suppression or reduction according to the Engel modified classification.\n\n\nRESULTS\n: Twelve patients underwent MST alone (MSTa), and 50 had MST with another procedure. The main MST sites were BA 4 (61%) and 3, 1, 2 (58%); in 22% of cases, MST was performed in BA 44, 22, 39, and 40. Permanent neurological deficits were observed in 4 (6.4%) patients; 2 minor deficits were MST related (3.2%). A reduction in the seizure rate of at least 50% was seen in 79% of patients (MSTa group, 75%), and 42% became seizure free (MSTa group, 33%).\n\n\nCONCLUSION\n: This study demonstrates the efficacy and low morbidity of radiating MST performed under neuronavigation and intraoperative electrocorticography.\n\n\nABBREVIATIONS\n: BA, Brodmann areaEEG, electroencephalogramFDG, 18-fluorodeoxyglucoseioECoG, intraoperative electrocorticographyMRE, medically refractory epilepsyMST, multiple subpial transectionMSTa, multiple subpial transection aloneMST+, multiple subpial transection with other procedures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24157965,"openaccessinfo":{"externalids":{"MAG":"2030283862","ACL":null,"DOI":"10.1227\/NEU.0b013e31828ba750","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BackgroundDrug-resistant epilepsy (DRE) is a chronic condition derived from spontaneous changes and regulatory effects in the epileptic brain. DNA methylation, an inheritable but reversible epigenetic change, may participate in this complicated regulatory network. As demethylation factors, ten-eleven translocation (TET) family members have become a focus in recent studies of neurological disorders. Thus, we aimed to unravel their role in DRE and their function related to the possible refractory factor ABCB1 in a blood-brain barrier (BBB) model.MethodsWe quantified and localized TET1, TET2 and 5-hydroxymethylcytosine (5-hmC) in the temporal lobe cortex of DRE patients (n\u2009=\u200927) and traumatic brain haemorrhage controls (n\u2009=\u200910) by immunochemical staining. TET2 and ABCB1 expression patterns were determined in the temporal cortex and isolated brain capillaries of DRE patients using immunohistological detection and Western blot analysis, respectively. A BBB model constructed with hCMEC\/D3 cells was used to verify the demethylation and regulatory effects of TET2 on ABCB1.ResultsTET2 expression was significantly increased in the temporal cortical tissue of DRE patients with or without hippocampal sclerosis (HS) compared to control patients, while TET1 and 5-hmC showed differences in expression. We also discovered that the vascular endothelium of DRE patients has a strong affinity for TET2. ABCB1 and TET2 have identical densities in the DRE temporal cortex, and they both have evidently higher expression in the vascular endothelium from the neocortex of DRE patients. In the BBB, TET2 depletion can cause attenuated expression and function of ABCB1, as well as a pattern of higher methylation in CpG islands of the ABCB1 promoter.ConclusionsThrough a cohort study performed on the temporal cortex and brain vessels of DRE patients, we identified a novel epigenetic marker, TET2. Data from experiments in a BBB model suggest that TET2 has a specific regulatory effect on ABCB1, which may serve as a potential mechanism and target in DRE and requires further research.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":241712855,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-676547\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-676547\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This book defends two main ideas: there is a need and a market for better specialised dictionaries for learners; we need a sound theoretical framework for coping with known and unknown challenges (for example the Internet) in the realm of pedagogical specialised lexicography. Both themes were Enrique Alcaraz's driving force during his life. Hence, his memory deserves this book that has been written by leading scholars in the field - they have compiled more than 70 dictionaries and published hundreds of books and articles on the topics here discussed - although only two of them knew him in person.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":107282901,"openaccessinfo":{"externalids":{"MAG":"1592376","ACL":null,"DOI":"10.1515\/9783110231335","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Food size selection of the mosquitofish , (;ambllsia a.(finis affinis. was measured in aquaria using juvenile stages of the mosquito, Clllex tarsalb;, as prey. F ish size varied from recen tly born fry to large adult females. Food size selection was positively correlated with fish size . Mosquitofish fry (6-8 111m standard ll'ngth) attacked and ate primarily first and second instar larvae. Fry attacked larger instars, but attack success on these was low (0 50%). Fish larger than 20 mm attached primarily pupae and third and fourth instar larva . No first instar mosquitoes were ea tcn. A ttack success for these fish was abovc 65'Yr) for all j n stars. . INTRODUCTION. Gambllsia affinis is widely used to control mosquito populations, but the efficacy of these fish often varies widely between habitats. Although some information is available on the diets of Gambllsia (Barney and Anson 1920; Hess and Tarzwell 1942; Harrington and Harrington 1961; Washino and Hokama 1967; Maglio and Rosen 1969; Walters and Legner in press) relatively little is known about factors influencing predation rates or prey choice, and consequently, little is known about factors affecting the efficacy of the control process. It is extremely difficult to study the predation process in the field since so many factors affecting predation are uncontrolled (Le. , fish size , hunger state, and experience; prey availability , distribution and escape mechanisms; environmental temperature and light levels). By studying predation in the laboratory , we can isolate specific factors and determine their importance to the feeding process. This approach has been used profitably by others studying fish predation (O'Brien 1979 , Werner 1977). When enough factors have been investigated we may begin to understand Gambusia predation in a complicated natural environment. An important factor affecting fish feeding is size-selective predation (Brooks and Dodson 1965). There has been a considerable amount of work in aquatic ecology which demonstrates that most fish feed on specific sizes of organisms and that this size selectivity is so important that it can modify community structure (for review, see O'Brien 1979). Most work in this area has emphasized the feeding behavior of large fish, and the conclusion often reached is that \"planktivorous fish ~onsume many more large-sized prey than would be the case if the feeding were random\" (O'Brien 1979). Unfortunately , the diets of fish larvae and fry are often ignored, so that little is known about their size selectivity. A priori, we would not expect a larval fish to consume the largest prey in the environment when that prey might be the same size or larger than the predator. Werner (1974) has shown that fish size is important in determining handling time in sunfishes, and Elston (1975) has shown how fish size influences prey size selection in Menidia audcns. 48 This study reports preliminary results on the selective feeding behavior of Cambllsia affinis ranging in size from recently born fry to large adult females. The prey organisms tested were the five instars of the mosquito, Cuip.x tarsalis. METHODS.The prey selection experiments were conducted in glass aquaria (5 gallon) filled with 17 liters of water. Surface areas of the rectangular aquaria were 820 cm2. Temperatures were maintained at 25\u00b0 \u00b1 2\u00b0C during acclimation and during the feeding trials. Flourescent room lights illuminated the aquaria from above. The experimental fish were from a wild stock obtained at the Wheatland, California, Sewage Treatment Plant. The fish were maintained in the laboratory on prepared flake diets. Fry (6-8 mm) used in the experiments were born in the lab and were between 6 and 60 days old. The larger fish, taken from the field, may have had some feeding experience on mosquito larvae; but they had been kept in the laboartory for over 120 days without access to natural prey organisms. The Culp.x tarsalis (DaviS strain) were reared in synchronous cultures. In most trials 20 of each instar (.1-4 and pupae-P) were placed in a 25 mm diameter petri dish before an experimen t. In the first set of trials only instars 1-4 were used. Ten feeding trials were conducted on three separate dates. Before a trial, the fish were allowed to feed for one hour on a flake diet. Five similarly sized fish were then placed in a test aquarium and kept for three hours without food to provide a moderate, standardized, hunger level. The prey organisms were introduced by sinking the petri dish in the center of the aquaria. Behavioral observations were made \u00b7throughout the feeding bout. The number of attacks and attack success on particular insects were recorded during the trial. A larvae was considered \"attacked\" if the fish contacted it. A successful attack resulted in an ingestion. Unsuccessful attacks occurred if the instar evaded the predator or if the predator discharged the prey from its mouth. The accuracy of this behavioral observation is limited due to the difficulty in correctly differentiating the five instars during an attack. The fish usually began feeding within thirty sec. after the prey were introduced, and feeding activity often decreased considerably after the first 3 to 5 min. This was probably due to the fish becoming satiated and to the fact that after several minutes, many of the mosquitoes had moved to the periphery of the tank and 'were relatively inconspicuous there in the meniscus. After the fish had fed for ten minutes, they were netted from the tank and preserved. The actual ingestion of the various instars was determined by dissecting the fish and measuring the head capsule widths of the prey at 30X magnification. The standard length of each fish was also recorded. Many of the larvae in the guts were partially digested. However, head capsules of the larvae were usually intact and were used to identify and count instars. The head capsule widths of the different instars were determined on freshly preserved larvae (Figure 1 B), which allowed us to assign a prey item to an instar category. The relationship between head capsule width and total body length (tip of head of the end of the abdomen with siphon excluded) was also determined (Figure 1 A). This regression was used to assign lengths to the prey eaten. RESULTS.The feeding trials demonstrated that Cambusia size effects prey-size selection. Fish less than 8 mm ate primarily first and second instar larvae (Figure 2). The few third instar larvae eaten had an estimated size of 3 mm. No fourth instar or pupae were eaten by fry. Cambusia between 12 and 18 mOl ate approximately equal proportions of all instars. The A 6 \u2022 \u2022 LARVAE 6 PUPAE \u2022\u2022 5 .. ,","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52236212,"openaccessinfo":{"externalids":{"MAG":"1525768368","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The problem of non-standard scaling of the 1\/f noise in thin manganite films was revisited in the above paper, suggesting the quantum theory of fundamental flicker noise for the interpretation of the unusual dependence of the normalized Hooge parameter on the sample volume. Experimental evidence has been reported, showing that in these materials such volume dependence is, instead, an artifact of extrinsic noise sources, e.g., contact noise. Moreover, the proposed theoretical model implies a linear temperature dependence of the Hooge parameter, which is against the experimental data reported here. Based on these arguments, it is possible to conclude that the quantum theory of fundamental flicker noise cannot be applied to the case of La2\u22153Sr1\u22153MnO3 thin films.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122183953,"openaccessinfo":{"externalids":{"MAG":"2061795451","ACL":null,"DOI":"10.1063\/1.4868864","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/aip.scitation.org\/doi\/pdf\/10.1063\/1.4868864","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract Interventions against obesity, are mainly around changing calorie intake and energy expenditure. Recently, some studies focused on the influence of circadian time of food intake on metabolic status. Here, we compare the role of calorie restriction and time restricted feeding followed by high-fat diet started post weaning, First, 52 male Wistarrats (3 weeks old) were divided into two groups: the high-fat diet (HFD, n = 42) and the control group (CON1, n = 11). After 17 weeks, five rats were randomly selected from each group for sample preparation. In the second phase, the animals in HFD group were assigned into four groups (n = 9): (1) 30% calorie restriction (CR), (2) day intermittent fasting (DIF), (3) night intermittent fasting (NIF), (4) adlibitum food intake (AL), (5) remained animal from the first phase control (CON2). Seventeen weeks of HFD started post-weaning did not cause fatty liver but it caused a significant difference in the body and the adipose tissue weight (P0.05). The results showed that longtime HFD did not lead to liver steatosis while the incorrect time of food intake predisposes the animal to the upcoming liver disease. This data indicate a significant role of timing of food intake rather than nutrition composition itself.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":89706302,"openaccessinfo":{"externalids":{"MAG":"2808569549","ACL":null,"DOI":"10.1080\/09291016.2018.1478635","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Adrenal steroidogenesis is under the control of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis. Furthermore, metabolic factors including insulin and obesity-related signals may play a role in the regulation of both enzymes involved in the steroidogenetic pathways, as well as in the regulation of the HPA axis. In women with the polycystic ovary syndrome (PCOS), cortisol production rate is probably normal, although adrenal androgens can be overproduced in a subset of affected women. Cortisol metabolism and regeneration from inactive glucocorticoids can also be disrupted in PCOS, thereby contributing to determining an adrenal hyperandrogenic state. Finally, overactivity of the HPA axis may be related to the high prevalence of psychopathological and eating disorders in women with PCOS, implying a maladaptive allostatic load in the adaptive mechanisms to chronic stress exposure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":70389285,"openaccessinfo":{"externalids":{"MAG":"1966931060","ACL":null,"DOI":"10.1586\/eem.12.42","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nConcession stands at high school events are exempt from the US Department of Agriculture regulations for school foods. Concessions are generally stocked with unhealthy foods since healthy foods are believed to have lower sales and profit margins.\n\n\nMETHODS\nConcession stand sales for two seasons of high school fall sports in Muscatine, Iowa were compared. In between seasons, two types of changes were made: (i) addition of new healthier concession options and (ii) substitution of healthier ingredients (less saturated fat, no trans fat). Satisfaction surveys of students and parents were conducted before and after the changes. Data were collected in 2008 and 2009 and analyzed in 2012-13.\n\n\nRESULTS\nRevenue per game was similar between years, even with the introduction of healthier items and ingredient changes. In 2009, the new healthy foods comprised 9.2% of total revenue and sales of some new items increased with each game. The 'healthy makeover' had no influence on student satisfaction but it improved parent satisfaction (P < 0.001).\n\n\nCONCLUSIONS\nThis compelling test of concept shows that offering healthier items can be good for both sales and satisfaction. While this study was conducted with concession stands, the principles can be carried over into other food retail settings.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205295916,"openaccessinfo":{"externalids":{"MAG":"2156966326","ACL":null,"DOI":"10.1093\/pubmed\/fdu015","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/jpubhealth\/article-pdf\/37\/1\/116\/4438316\/fdu015.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The goal of this research is to synthesize biodegradable polymers that would have nitroxyl radical biological functions. Linear aliphatic polyesters were chosen as the starting materials. The hydroxyl-terminated polylactide\/e-caprolactones (PBLC-OHs) were first synthesized by melt ring-opening copolymerization in the presence of benzyl alcohol and stannous octoate. PBLC-OHs were used as the precursor for the synthesis of double bond-functionalized polylactide\/e-caprolactones (PBLC-Mas) by reacting the hydroxyl end groups of PBLC-OH with maleic anhydride in melt at 130 \u00b0C. Acrylic acid\/lactide\/e-caprolactone graft copolymers (PBLCAs) were then successfully carried out by the radical copolymerization of acrylic acid and PBLC-Ma initiated by azobisisobutyronitrile. Finally, nitroxyl radicals [4-amino-2,2,6,6-tetramethylpiperidine-1-oxy (TAM)] were incorporated into the carboxylic acid sites of the acrylic acid\/ lactide\/e-caprolactone copolymer (TAM-PBLCA) by reacting TAM with PBLCA in the presence of N,N9-carbonyl diimidazole. A high content of TAM was incorporated into the PBLCA copolymer. The polymers synthesized were characterized by H and C NMR, Fourier transform infrared spectroscopy, and electron paramagnetic resonance spectra. \u00a9 2001 John Wiley & Sons, Inc. J Polym Sci Part A: Polym Chem 39: 4214\u20134226, 2001","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56437619,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Osteosarcoma is the most common primary malignant bone tumor, and there are few ideal clinically available drugs. The bromodomain and extraterminal domain (BET) protein is an emerging target for aggressive cancer, but therapies targeting the BET in osteosarcoma have been unsuccessful in clinical trials to date, and further exploration of specific BET inhibitors is of great significance. In our study, we demonstrated that NHWD-870, a potent BET inhibitor in a phase I clinical trial, significantly inhibited tumor proliferation and promoted cell apoptosis by reversing the oncogenic signature in osteosarcoma. More importantly, we identified NHWD-870 impeded binding of BRD4 to the promoter of GP130 leading to diminished activation of JAK\/STAT3 signaling pathway. Furthermore, GP130 knockdown significantly sensitizes the chemosensitivity in vitro. In OS cell-derived xenografts, NHWD-870 effectively inhibited the growth of osteosarcoma. Beyond that, NHWD-870 effectively inhibited the differentiation and maturation of precursor osteoclasts in vitro and attenuated osteoclast-mediated bone loss in vivo. Finally, we confirmed the efficacy of synthetic lethal effects of NHWD-870 and cisplatin in antagonizing osteosarcoma in a preclinical PDX model. Taken together, these findings demonstrate that NHWD-870, as an effective BET inhibitor, may be a potential candidate for osteosarcoma intervention linked to its STAT3 signaling inhibitory activity. In addition, NHWD-870 appears to be a promising therapeutic strategy for bone-associated tumors, as it interferes with the vicious cycle of tumor progression and bone destruction.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-10":1,"unknown":2}},"corpusid":235363302,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fonc.2021.642134","PubMedCentral":"8219214","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2021.642134\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A new optoelectronic packaging technology is presented which permits highly accurate fiber-to-chip alignment at low cost. Instead of the more common methods employed in fabricating optical subassemblies, which use leadframe, precision plastic-molding, or silicon-optical-bench technology, here fiber guides are fabricated in a photoresist by use of standard photolithographic procedures. By this means the fiber guides are directly created on an entire wafer of either VCSELs or receivers, resulting in structures with very tight dimensional tolerances fabricated at very low cost. After dicing, a fiber is interfaced with a chip under computer control using a very simple semiautomatic tool to insert the fiber into the fiber guide. This new technology may be used in the fabrication of a wide variety of single or multi-channel optoelectronic transceivers.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":110911371,"openaccessinfo":{"externalids":{"MAG":"2157937986","ACL":null,"DOI":"10.1109\/ECTC.2001.927726","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ability of neural networks (NNs) to learn and remember multiple tasks sequentially is facing tough challenges in achieving general artificial intelligence due to their catastrophic forgetting (CF) issues. Fortunately, the latest OWM Orthogonal Weights Modification) and other several continual learning (CL) methods suggest some promising ways to overcome the CF issue. However, none of existing CL methods explores the following three crucial questions for effectively overcoming the CF issue: that is, what knowledge does it contribute to the effective weights modification of the NN during its sequential tasks learning? When the data distribution of a new learning task changes corresponding to the previous learned tasks, should a uniform\/specific weight modification strategy be adopted or not? what is the upper bound of the learningable tasks sequentially for a given CL method? ect. To achieve this, in this paper, we first reveals the fact that of the weight gradient of a new learning task is determined by both the input space of the new task and the weight space of the previous learned tasks sequentially. On this observation and the recursive least square optimal method, we propose a new efficient and effective continual learning method EOWM via enhanced OWM. And we have theoretically and definitively given the upper bound of the learningable tasks sequentially of our EOWM. Extensive experiments conducted on the benchmarks demonstrate that our EOWM is effectiveness and outperform all of the state-of-the-art CL baselines.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":2,"2024-30":1}},"corpusid":244463270,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2111.10078"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. Large wood (LW) addition is often part of fish habitat restoration projects. However, there is limited information about the spatial-temporal variability in hydraulic changes after LW additions. We investigated reach scale hydraulic changes relevant to juvenile Coho Salmon survival triggered immediately after the addition of LW. We used Nays2DH, an unsteady two-dimensional flow model to quantify patterns and magnitudes of changes of stream velocity (v) and shear stress (\u03c4) in three alluvial gravel reaches. The study sites are located in low gradient reaches draining 5 to 16\u2009km2 in the Oregon Coast Range. Survivable habitat was characterized in terms of critical swim speed for juvenile Coho and bed stability considering the critical \u03c4 required to mobilize the median bed particle size. Model predictions indicated that survivable habitat during bankfull conditions, measured as the area with v below the critical swim speed for juvenile Coho, increased by 95\u2013113\u2009% after the LW restoration. Bed stability also increases between 86\u2013128\u2009% considering the \u03c4 required to mobilize the median bed particle size. Model predictions indicated more habitat created in the larger site, however considering that wood would move more frequently in this site there appears to be a trade-off between the timing and the resilience of restoration benefits. Overall, this study quantifies how the addition of LW potentially changes stream hydraulics to provide a net benefit to juvenile salmonid habitat. Our findings are applicable to stream restoration efforts throughout the Pacific Northwest.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":149648252,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5194\/esurf-2019-10","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5194\/esurf-2019-10","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We construct a data set of all 429 tied at the half regular season National Football League (NFL) games between 1994 and 2012. We then examine whether or not the path taken to reach the tie (e.g., rushing yards, turnovers, etc.) has any ability to predict the eventual winner. Our main finding is that only the point spread is significantly predictive, although there is weak evidence to suggest that allowing more sacks reduces the chances of winning. Surprisingly, we find that the team receiving the first possession of the second half does not enjoy a statistically significant advantage. Teams should thus simply try to maximize their first half lead without expecting that first half strategies such as \"establishing the run\" will pay dividends in the second half.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-26":1,"unknown":2}},"corpusid":155765737,"openaccessinfo":{"externalids":{"MAG":"2320101512","ACL":null,"DOI":"10.1177\/1527002514539688","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This chapter is a survey on a sampling technique grown in parallel to gas chromatography since its early years, and which nowadays enjoys a remarkable renewal of interest thanks to the new strategies of analysis introduced with the \"omics\" sciences and adopted in food (aroma) analysis, and the continuous evolution of technology (mainly multidimensional separation techniques and mass spectrometry) and data elaboration. After the introductory sections concerning headspace definitions and history, the chapter describes the approaches to static headspace (S-HS) and dynamic headspace (D-HS), and to high-concentration capacity sampling techniques. The latter are techniques bridging the two approaches S-HS to D-HS, where the analytes are accumulated from a vapor or liquid phase on a stationary phase by sorption or adsorption. The following sections deal with quantitation with headspace sampling in both static and dynamic modes illustrating the approaches that can be adopted as a function of the physical status (liquid or solid) of the investigated matrix. The last section describes the use of headspace with non-separative methods, i.e., directly combined to mass spectrometry and chemometric elaboration without a preliminary chromatographic separation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210298262,"openaccessinfo":{"externalids":{"MAG":"2980709120","ACL":null,"DOI":"10.1039\/9781788015752-00001","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/books.rsc.org\/books\/edited-volume\/chapter-pdf\/1579341\/bk9781788011273-00001.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Seven constituents (I-VII) were isolated from the bark of Hibiscus syriacus and identified as nonanedioic acid (I), suberic acid (II), 1-octarcosanol (III), beta-sitosterol (IV), 1,22-docosanediol (V), betulin (VI) and erythrotriol (VII). VII was obtained from the plant for the first time, I, II, III and VI were isolated from Malvaceae plants for the first time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1445542,"openaccessinfo":{"externalids":{"MAG":"2397270685","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Over the past several decades, high-resolution sediment-charcoal records have been increasingly used to reconstruct local fire history. Data analysis methods usually involve a decomposition that detrends a charcoal series and then applies a threshold value to isolate individual peaks, which are interpreted as fire episodes. Despite the proliferation of these studies, methods have evolved largely in the absence of a thorough statistical framework. We describe eight alternativedecompositionmodels(fourdetrendingmethodsusedwithtwothreshold-determinationmethods)andevaluate their sensitivity to a set of known parameters integrated into simulated charcoal records. Results indicate that the combination of a globally defined threshold with specific detrending methods can produce strongly biased results, depending on whether or not variance in a charcoal record is stationary through time. These biases are largely eliminated by using a locally defined threshold, which adapts to changes in variability throughout a charcoal record. Applying the alternative decomposition methods on three previously published charcoal records largely supports our conclusions from simulated records. We also present a minimum-count test for empirical records, which reduces the likelihood of false positives when charcoal counts are low. We conclude by discussing how to evaluate when peak detection methods are warranted with a given sediment-charcoal record.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":2781372,"openaccessinfo":{"externalids":{"MAG":"2120575990","ACL":null,"DOI":"10.1071\/WF09134","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Assessment of latent Alternaria alternata infections in table grapes indicated that infections occurred in commercial vineyards during the entire period of bunch development. Mature bunches were asymptomatic despite high levels of A. alternata recovered from triple-sterilized bunch tissue.\u00a0 Inoculation studies showed no shift in disease susceptibility of ripening grape berries, and postharvest rot was not related to the level of natural infection. Late season fungicidal sprays, or dip treatments that ensured better penetration and coverage of inner parts, resulted in no meaningful reduction in postharvest rot. Based on the behaviour of the pathogen, it is suggested that additional fungicide programmes for the control of the disease should not be followed in commercial vineyards. Instead, attention should be given to physiological and stress factors, such as mechanical and sulphur dioxide damage that might predispose cold-stored bunches to A. alternata decay.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88839394,"openaccessinfo":{"externalids":{"MAG":"2530616930","ACL":null,"DOI":"10.21548\/15-2-2280","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.journals.ac.za\/index.php\/sajev\/article\/download\/2280\/1358","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Sliced sheet of finished leather,stained by Cain Nile blue,was examined under multimedia microscope.According to the result of examination,the relationship between histology character and properties of leather was analyzed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137917554,"openaccessinfo":{"externalids":{"MAG":"2354499446","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Heterogeneity and dynamicity of pervasive, service-based environments require the construction of flexible multimodal interfaces at run time. In this paper, we present how we use an autonomic approach to build and maintain adaptable input multimodal interfaces in smart building environments. We have developed an autonomic solution relying on interaction models specified by interaction designers and mediation components implemented by software developers. An interaction model is built around the notions of abstract device and abstract applications. The role of the autonomic manager is to build complete interaction techniques based on runtime conditions and in conformance with the predicted models.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":18129080,"openaccessinfo":{"externalids":{"MAG":"2066806923","ACL":null,"DOI":"10.1109\/SCC.2014.41","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The further development of the liberation struggles which are underway in Angola, Guine, and Mozambique is creating a revolutionary nationalism very different from that earlier brand of nationalism which brought formal independence to African territories north of the Zambezi. This is a reality which supporters of these struggles and of the movements (MPLA, PAIGC, FRELIMO) which lead them must face unflinchingly, for it is at once these movements' greatest strength and a harbinger of future difficulties in their finally winning their freedom. In this paper we shall both specify, briefly, the character of this \"revolutionary nationalism\" as it finds expression in Angola, Guine and Mozambique, and examine a few of the broader implications of this pattern-its possible effect upon the rest of Africa, its likely impact upon the calculations of Portugal and her allies, its lessons for all those who would support the African cause.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":3}},"corpusid":142894373,"openaccessinfo":{"externalids":{"MAG":"1594491050","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A primary-side regulation AC-DC converter operating in the PFM (Pulse Frequency Modulation) mode with a high precision output current is designed, which applies a novel inductance compensation technique to improve the precision of the output current, which reduces the bad impact of the large tolerance of the transformer primary side inductance in the same batch. In this paper, the output current is regulated by the OSC charging current, which is controlled by a CC (constant current) controller. Meanwhile, for different primary inductors, the inductance compensation module adjusts the OSC charging current finely to improve the accuracy of the output current. The operation principle and design of the CC controller and the inductance compensation module are analyzed and illustrated herein. The control chip is implemented based on a TSMC 0.35\u03bcm 5V\/40V BCD process, and a 12V\/1.1A prototype has been built to verify the proposed control method. The deviation of the output current is within \u00b13% and the variation of the output current is less than 1% when the inductances of the primary windings vary by 10%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54077346,"openaccessinfo":{"externalids":{"MAG":"2475135816","ACL":null,"DOI":"10.6113\/JPE.2016.16.3.840","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Measuring physical activity is a critical issue for our understanding of the health benefits of human movement. Machine learning (ML), using accelerometer data, has become a common way to measure physical activity. ML has failed physical activity measurement research in four important ways. First, as a field, physical activity researchers have not adopted and used principles from computer science. Benchmark datasets are common in computer science and allow the direct comparison of different ML approaches. Access to and development of benchmark datasets are critical components in advancing ML for physical activity. Second, the priority of methods development focused on ML has created blind spots in physical activity measurement. Methods, other than cut-point approaches, may be sufficient or superior to ML but these are not prioritised in our research. Third, while ML methods are common in published papers, their integration with software is rare. Physical activity researchers must continue developing and integrating ML methods into software to be fully adopted by applied researchers in the discipline. Finally, training continues to limit the uptake of ML in applied physical activity research. We must improve the development, integration and use of software that allows for ML methods' broad training and application in the field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247501022,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjsem-2021-001259","PubMedCentral":"8928282","ArXiv":null},"license":"CCBY","url":"https:\/\/bmjopensem.bmj.com\/content\/bmjosem\/8\/1\/e001259.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The statistical relationship between the quasi-biennial oscillation (QBO) and tropical cyclone (TC) activity is explored, with a focus on the North Atlantic. Although there is a statistically significant relationship between the QBO and TCs in the Atlantic from the 1950s to the 1980s, as found by previous studies, that relationship is no longer present in later years. Several possibilities for this change are explored, including the interaction with ENSO, volcanoes, QBO decadal variability, and interactions with solar forcing. None provides a completely satisfying explanation. In the other basins, the relationship is weaker than in the Atlantic, even in the early record.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5993382,"openaccessinfo":{"externalids":{"MAG":"2136382164","ACL":null,"DOI":"10.1175\/2010JCLI3575.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One in seven men in the United States will be diagnosed with prostate cancer in his life time, in part because of the prevalence of screening for serum levels of prostate specific antigen (PSA). However, this has led to the overtreatment of the disease, leading to recommendations against frequent PSA testing and establishing the need for a more informative biomarker in prostate cancer. Circulating tumor cells (CTCs) are rare cells present in the blood stream of cancer patients at the low frequency on the order of one CTC in one billion normal blood cells. The graphene oxide chip (GO Chip) is a microfluidic CTC capture device with increased sensitivity and purity due to its use of the nanomaterial graphene oxide to present a capture antibody against the epithelial cellular adhesion molecule (EpCAM). In this study, whole blood was collected from 50 prostate cancer patients, including those with metastatic, localized, castrate resistant, and castrate sensitive disease, and analyzed using the GO Chip. Captured cells were stained for cytokeratin, CD45, and DAPI, with nucleated cytokeratin positive cells being denoted as CTCs. CTCs were detected in 47 out of 50 patients, and an average of 5.94 CTCs\/mL was recovered from each sample. Correlation of CTCs with surrogate endpoints could improve the utility of CTCs as a liquid biopsy, potentially advancing their application in translational research. Citation Format: Molly Kozminsky, Hyeun Joong Yoon, Nallasivam Palanisamy, Kathleen Cooney, Maha Hussain, Ajjai Alva, Todd Morgan, Sunitha Nagrath. Application of a graphene oxide based microfluidic device (GO Chip) to prostate cancer circulating tumor cell capture and analysis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1585. doi:10.1158\/1538-7445.AM2015-1585","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78396925,"openaccessinfo":{"externalids":{"MAG":"2565138054","ACL":null,"DOI":"10.1158\/1538-7445.AM2015-1585","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Effects of the 65 eV \u2013 320 eV energy nitrogen ion beam irradiation on surface structure and electrical properties of the Au -GaAs and Co-GaAs Schottky contacts were investigated. Formation of the thin GaN or GaAsxN1-x type layer as a result of the GaAs surface 65 eV and 320 eV nitrogen ion beam treatment was observed. Thickness of this layer increased with increase of the ion energy and ion current density. Ion beam nitridation in all cases resulted in decreased effective barrier height of Au-nGaAs and Co-nGaAs Schottky contacts. Low frequency noise of the irradiated Schottky contacts measured at room and liquid nitrogen temperatures in all cases exceeded noise of the reference samples. Current-voltage (I-V) characteristics of Au-GaAs and Co-GaAs fabricated on nitrogen ion beam irradiated GaAs surface were very similar. It means, that I-V characteristics of these contacts depends on properties of the irradiation modified GaAs surface layer. There were revealed, that the influence of the nitrogen ion beam irradiation on electrical characteristics of the Schottky contacts increases with increase of the ion energy, ion current density and treatment time. GaAs Schottky contact low frequency noise level, non-ideality factor and effective barrier height increased as a result of the ion irradiation angle change from glancing (oblique) to the normal.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":139013594,"openaccessinfo":{"externalids":{"MAG":"2169070170","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A first step in approaching the autoimmune-disease myasthenia gravis from behavior therapy is reported. 23 patients were investigated by a two to four hours lasting structured behavior analytic interview (SBAI) and a set of standardized questionnaires, used routinely for neurotic reactions. A marked disability was found in occupation. Significant social phobic and depressive reactions became obvious in the interview but not in the questionnaire data. Half of the subjects reported interactions between emotions, cognitions and motoric behavior. Onset of sufficient treatment was preceded by a diagnostic Odyssey, lasting up to 9 years. Our results correspond to the sparse literature. Further basic research on the subject has to be done that may lead to first experimental behavior therapeutic trials.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22224914,"openaccessinfo":{"externalids":{"MAG":"2286206366","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo investigate the effects of laser in situ keratomileusis (LASIK) on the corneal endothelium, retina and optic nerve for correcting residual myopia caused by undercorrection or regression.\n\n\nMETHODS\nThe pre- and post-operative values of central corneal endothelium and electrophysiological functions of retina and optic nerve were analyzed respectively in 23 eyes of 18 patients who received LASIK retreatment. The endothelium checked by contact specular microscopy was analyzed for central cell density (CCD), coefficient of cell variation in size and hexagonality preoperatively and 1, 4, 12 weeks after the operation. The amplitude and latency of P(100) in standard pattern visual evoked potentials (P-VEPs), that of a, b waves of different reactions in flash electroretinograms (F-ERGs) and also the total amplitude of oscillatory potentials (OPs) were evaluated preoperatively and 2, 12 weeks after the operation.\n\n\nRESULTS\nThe mean CCD decreased significantly (3.94%) one week after the operation (P < 0.01). The change was negatively correlated with the thickness of residual untreated posterior cornea (r = -0.719, P < 0.01) and not significantly correlated with the amount of laser pulse (r = 0.371, P > 0.05). There was no significant difference between preoperative and either 4 or 12 week postoperative CCD (P > 0.05). No significant differences in mean coefficient variation and hexagonality were found between preoperative and postoperative values in the follow up (P > 0.05). Examination of electrophysiological function showed that the amplitude of P(100) increased and the latency of P(100) decreased 2 and 12 weeks postoperatively. The significant changes were only at spatial frequency 34' in the P-VEPs test (P < 0.05). In F-ERGs test, there was no significant change in amplitude, latency of a, b waves or total amplitude of OPs between pre-operative and either 2 or 12 week post-operative values (P > 0.05).\n\n\nCONCLUSIONS\nRetreatment after LASIK may cause a reversible reduction of CCD with no morphological changes in a short period (1 week) after the operation. It was not absolutely safe for corneal endothelium when the thickness of residual untreated basal cornea approaches to 200 micro m. These results show that the operation seems not to cause functional impairment in the retina and optic nerve. And it also can improve the quality of vision for some degrees.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25825951,"openaccessinfo":{"externalids":{"MAG":"2410651596","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The flexography ink has disadvantage in a deinking process because it tends to form too fine particles in alkali condition to be removed in flotation deinking. The influence of pH conditions on the particle size of phthalocyanine cyan ink used for flexo-printing was investigated to see the effect of pH conditions on flexography ink dispersion. Flexography ink particles prepared by grinding dried ink films were used in this experiment. Greater reduction of the ink particle size was noticed under alkaline pH condition, which was attributed to dissolution of resin component of the ink. Adsorption behavior of flexography ink onto pigment particles was examined using clay and talc as substrate pigments. Pretreatment of inorganic pigments with a cationic poly-DADMAC increased the surface adsorption of flexography ink particles, which improved the removal of the inks by centrifugal sedimentation of inorganic pigments. Most efficient removal of the ink particles was achieved when an optimal addition level of the cationic polymer was used for pretreatment of inorganic pigments, and this optimal addition level corresponds to the surface saturation point of the polyelectrolyte. Adsorption of flexography ink particles onto inorganic pigments improved the ink removal in flotation deinking since the pigment particles has the optimal particle size for flotation deinking.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137640685,"openaccessinfo":{"externalids":{"MAG":"2059035264","ACL":null,"DOI":"10.7584\/KTAPPI.2012.44.5.008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"TWENTY-SEVEN THREE-SPAN AND TWELVE TWO-SPAN BEAMS, ALL OF RECTANGULAR CROSS-SECTION, WERE TESTED TO DESTRUCTION UNDER VARIOUS ARRANGEMENTS OF CONCENTRATED LOADS. THE RESULTS OF THESE TESTS ARE PRESENTED. REDISTRIBUTION OF MOMENTS WAS PRACTICALLY COMPLETE IN THE MAJORITY OF THE BEAMS. THE CURVATURE DISTRIBUTIONS ALONG THE PLASTIC LENGTHS HAVE BEEN STUDIED AND THE ROTATIONS DEDUCED THEREFROM ARE COMPARED WITH THOSE OBTAINED ON THE BASIS OF THE STANDARD MOMENT- CURVATURE RELATIONSHIP. \/AUTHOR\/","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118137666,"openaccessinfo":{"externalids":{"MAG":"623581105","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vertex configuration for a vertex in an orthogonal pseudo-polyhedron is an identity of a vertex that is determined by the number of edges, dihedral angles, and non-manifold properties meeting at the vertex. There are up to sixteen vertex configurations for any orthogonal pseudo-polyhedron (OPP). Understanding the relationship between these vertex configurations will give us insight into the structure of an OPP and help us design better algorithms for many 3-dimensional geometric problems. In this paper, 16 vertex configurations for OPP are described first. This is followed by a number of formulas giving insight into the relationship between different vertex configurations in an OPP. These formulas will be useful as an extension of orthogonal polyhedra usefulness on pattern analysis in 3D-digital images.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":28995578,"openaccessinfo":{"externalids":{"MAG":"1508198568","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tide and tidal-induced currents are important of hidro-oceanographic aspect of port planning and port design. Type of Lampung Bay tidal is mixed tide prevailing to semidiurnal, and the maximum tidal range is in order of magnitude of 1.5 meter. Meanwhile, the tidal-induced current of 1.5 meter tidal range is in order of magnitude of 0.11 cm\/sec. This tidal-induced current is relatively small compare to the actual current. From the 6 days current measurement shown that maximum of 10.83 cm\/sec could be found. The actual current predominantly coming from South East direction, namely 50,88% on ADCP1 and 63,11% on ADCP-2. Although the tidal-induced current is relative small, but it should be taken into consideration on port planning, because of its occurrence continuously.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":237109496,"openaccessinfo":{"externalids":{"MAG":"3160407575","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A multi-user repeat-accumulate interleave-division (RAID) system is considered for a multiple-access channel (MAC) with binary inputs, equal-power, and symbol synchronization. In the system, a regular repeat-accumulate (RA) code serially concatenated with block spreading is employed for each user. At the receiver, multi-user message-passing decoding is performed on a single factor graph. Over the MAC with additive white Gaussian noise (AWGN), a fixed point analysis is developed to obtain the optimal code rate and the spreading length that give the maximum sum rate for an arbitrary small decoding error rate.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":31100949,"openaccessinfo":{"externalids":{"MAG":"2111211848","ACL":null,"DOI":"10.1109\/TCOMM.2012.071812.110611","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Version 49 of these efficiency tables reported confirmed new solar cell results from July \u2013 December 2016. Three errors are corrected and three new results received after the publication cut-off date are briefly reviewed. Copyright \u00a9 2017 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":97008657,"openaccessinfo":{"externalids":{"MAG":"2135218826","ACL":null,"DOI":"10.1002\/pip.2667","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/pip.2667","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"One of simplest examples of navigation found in nature is run-and-tumble chemotaxis. Tumbles reorient cells randomly, and cells can drift toward attractants or away from repellents by biasing the frequency of these events. The post-tumble swimming directions are typically correlated with those prior, as measured by the variance of the reorientation angle distribution. This variance can range from large, in the case of bacteria, to so small that tumble events are imperceptible, as observed in choanoflagellates. This raises the question of optimality: why is such a range of persistence observed in nature? Here we study persistent run-and-tumble dynamics, focusing first on the optimisation of the linearised chemotactic response within the two-dimensional parameter space of tumble frequency and angular persistence. Although an optimal persistence does exist for a given tumble frequency, in the full parameter space there is a continuum of optimal solutions. Introducing finite tumble times that depend on the persistence can change this picture, illuminating one possible method for selecting tumble persistence based on species-specific reorientation dynamics. Moving beyond linear theory we find that optimal chemotactic strengths exist, and that these maximise reaction when swimming in a wrong direction, but have little or no reaction when swimming with even the slightest projection along the chemoattractant gradient.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11035015,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nIschemia\/reperfusion injury of human renal allografts has a number of clinically significant consequences. A number of mechanisms of ischemia\/ reperfusion injury have been elucidated, and there is evidence that apoptosis may be a contributing factor.\n\n\nMETHODS\nTo examine immediate posttransplant events, fixed tissue sections from paraffin-embedded wedge biopsy specimens taken before and after reperfusion of human renal allografts were stained using terminal deoxytransferase-mediated dUTP nick-end labeling to detect the DNA fragmentation characteristic of apoptosis. Thirty-six pairs of pre- and postreperfusion biopsy specimens were examined, 11 from living-related donor renal transplants and 25 from cadaveric donor transplants.\n\n\nRESULTS\nQuantitation of the terminal deoxytransferase-mediated dUTP nick-end labeling signal showed that significantly more apoptosis occurred in postreperfusion compared with prereperfusion biopsy specimens from cadaveric donor transplants, but a similar difference was not observed in living-related donor renal transplants. Furthermore, significantly more apoptosis was observed in postreperfusion biopsy specimens from cadaveric compared with living-related renal transplants. Postreperfusion biopsy specimens from kidneys that were cold preserved longer than 30 hr had a higher mean apoptosis score than those stored for less than 24 hr, but the result was not statistically significant.\n\n\nCONCLUSIONS\nThus, apoptosis occurs predominantly as a result of reperfusion after cold preservation of cadaveric donor renal allografts and provides additional information regarding the extent of ischemia\/ reperfusion injury in an organ. The clinical value of this information remains to be determined.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":24931971,"openaccessinfo":{"externalids":{"MAG":"2057295464","ACL":null,"DOI":"10.1097\/00007890-199810150-00010","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1097\/00007890-199810150-00010","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Introduction The efficacy of short-term spinal cord stimulation (stSCS) as a treatment for neuropathic pain in patients with postherpetic neuralgia (PHN) has already been validated. However, the potential alterations in brain functionality that are induced by such treatment have yet to be completely elucidated. Methods This study use resting-state functional magnetic resonance imaging (rs-fMRI) to detect the changes in regional homogeneity (ReHo) and degree centrality (DC) related to stimulator-induced pain relief in patients with PHN. A total of 10 patients with PHN underwent an MRI protocol at baseline and after stSCS. Alterations in ReHo and DC were then compared between baseline and after stSCS. We investigated the relationship between clinical parameters and functional changes in the brain. Results Clinical parameters on pain, emotion, and sleep quality were correlated with ReHo and DC. ReHo and DC were significantly altered in the middle temporal gyrus, precuneus, superior frontal gyrus, supramarginal gyrus, inferior parietal lobule, rolandic operculum, middle occipital gyrus, superior parietal gyrus, and the precentral gyrus after stSCS. A significant correlation was detected between ReHo changes in the middle occipital gyrus, precuneus, inferior parietal gyrus, and changes in pain, emotion, and sleep quality. A significant negative correlation was detected between DC changes in the middle temporal gyrus, rolandic operculum, supramarginal gyrus, precuneus, inferior parietal gyrus, and changes in pain, emotion, and sleep quality. Conclusion This study found that stSCS is able to induce ReHo and DC changes in patients with PHN, thus suggesting that stSCS can change brain function to alleviate pain, sleep, and emotional disorder.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251475702,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fnmol.2022.938280","PubMedCentral":"9405669","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2022.938280\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We describe a new experiment dealing with the multiphoton ionization of metastable atomic hydrogen H(2s). The ion yield has been measured in a relative way but it provides absolute photoionization rates. In the present contribution, the wavelength is tuned in the vicinity of the 2s-3p transition and the laser intensity is in the 10(7)-5 x 10(10) W cm(-2) range. Experimental photoionization rates and resonance width are found to be in agreement with theoretical predictions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121623231,"openaccessinfo":{"externalids":{"MAG":"2026099215","ACL":null,"DOI":"10.1088\/0953-4075\/29\/22\/014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The use of generators by the military is examined. The factors determining generator size and weight for a given power rating and the generator scaling laws are discussed. Size and weight reduction is shown to be primarily a function of improvements in material properties and cooling techniques.<>","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":41209275,"openaccessinfo":{"externalids":{"MAG":"2000864007","ACL":null,"DOI":"10.1109\/62.121940","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Digital counselling may improve patients' health outcomes, when eHealth solutions are accessible and tailored to the patients' needs, which is especially important for people with chronic and long-term conditions such as knee osteoarthritis. This study aims to identify patients' eHealth needs to improve the quality of digital counselling in a primary care management of symptomatic knee osteoarthritis. A qualitative study was used to collect patients' eHealth needs through semi-structured interviews in a single outpatient clinic in Finland between August 2020 and November 2020. The data was analyzed using both deductive and inductive content analysis approaches. The study was reported in accordance with the Consolidated Criteria for Reporting Qualitative research checklist to improve the transparency of the study.\nAnalysis of the data revealed five main categories to be considered when implementing digital counselling in patients with symptomatic knee osteoarthritis: background factors (functional impairments, health literacy, digital literacy, cost-related access barriers), resources (digital methods and materials), sufficiency (knee osteoarthritis-related knowledge and skills), implementation (simplicity, trust, patient-centeredness), and benefits (self-care capabilities, confidence).\nAccording to our findings, both health and digital literacy seems to be important contributors to the adoption of digital counselling in a primary care management of symptomatic knee osteoarthritis. New eHealth solutions should not replace the first visit in the outpatient clinic. Instead, the use of eHealth solutions should be based on the first visit, during which a trusting relationship between patients and healthcare providers is established. In future, the level of health and digital literacy in patients with symptomatic knee osteoarthritis should be taken account.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":263277362,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.23996\/fjhw.123000","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/journal.fi\/finjehew\/article\/download\/123000\/85514","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this study, numerical analysis of viscous flows is carried out based on the unstructured grid. There exist some difficulties in expressing and computing numerical derivatives on the unstructured grid due to lack of the structured characteristics. The general computer algorithms are developed to perform numerical derivatives easily and extended to be applicable to various geometries composed of hybrid meshes. And the optimal method of strongly implicit procedure is newly contrived to accelerate the rate of convergence in solving the pressure Poisson equation. To verify numerical schemes, the driven cavity problems of 2 and 3 dimension are simulated. The numerical results are compared with others and our numerical schemes are shown to be valid.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123336373,"openaccessinfo":{"externalids":{"MAG":"2246249265","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Mortality rate is high for older women with heart failure (HF) who are discharged to skilled nursing facilities (SNFs) after hospitalization, but little is known about their symptoms, nutritional factors, and pressure ulcer status and whether these variables predict the women's return to the community. Objectives: The aims of this study are to characterize symptoms (ie, dyspnea, cognitive dysfunction, depression, and pain) and nutritional and pressure ulcer status, evaluate relationships among symptoms, and examine predictors of return to the community among older women with HF admitted to SNFs. Methods: In this pilot observational study, data were collected retrospectively from the electronic medical records and the Minimum Data Set 3.0. Results: Data were obtained for 45 women with HF (mean age, 84.8 years). Frequency of symptoms was dyspnea 18%, cognitive dysfunction 20%, depression 5%, and pain 78%. Mean body mass index (BMI) was 29.8 kg\/m2. Frequency of pressure ulcer risk was 85% and 18% had pressure ulcers. The 4 symptoms were not significantly related. Younger age (odds ratio, 0.90; P = .023) and BMI of 25 kg\/m2 or greater (odds ratio, 5.31; P = .017) predicted return to the community. Conclusions: The women in this study had frequent pain, moderately frequent cognitive dysfunction, and high pressure ulcer risk. Surprisingly, few women had dyspnea or depression. Women who were younger with higher BMI were more likely to return to the community. The study needs to be replicated in a larger more diverse group of older patients with HF.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":45463962,"openaccessinfo":{"externalids":{"MAG":"2774923708","ACL":null,"DOI":"10.1097\/JCN.0000000000000422","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rheumatoid arthritis (RA) is an autoimmune disease associated with the recognition of self-proteins secluded in peripheral joints. We have previously identified a critical determinant of CII (CII-263-270) that triggers T cell immune responses in HLA-DR4 transgenic mice. In order to produce synthetic peptides with the potential of disrupting the DR4-restricted immune response, synthetic analog peptides were developed that contain site-directed substitutions in critical positions. These analog peptides were used to treat CIA in DR4 Tg mice. In this study, we identify two analog peptides of this immunodominant determinant which can suppress collagen-induced arthritis, CII 256-276 (F263N, E266D), also called A12, and CII 256-270 (F263N, E266A), also called A13. When either peptide is administered to DR4 mice at the time of immunization with CII, arthritis does not develop. Binding studies revealed that substitution of the amino acid (263 phenylalanine) of the CII peptide with an asparagine leads to a significant decrease in the affinity of the peptide to the MHC molecule DR4. On the other hand, substitution of Glu-266 with an alanine caused an increased affinity to the DR4 molecule, while aspartic acid substitution led to a significantly lower (35 fold reduction) in affinity. The modulation of collagen-induced arthritis was associated with an increase in T cell secretion of the Th2 cytokine IL-4 together with a decrease in the Th1 cytokine IFN-\u03b3. These data establish two analog peptides which are potent suppressors of the DR mediated immune response to CII. The effect is mediated, at least in part, by IL-4. These experiments represent the first description of an analog peptide of type II collagen recognized by T cells in the context of the human DR4 molecule that can suppress autoimmune arthritis.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":75464603,"openaccessinfo":{"externalids":{"MAG":"2360384701","ACL":null,"DOI":"10.2310\/6650.2005.00006.260","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"To aid understanding of and facilitate research into forecast-assimilation systems of Numerical Weather Prediction (NWP), idealized models that embody essential characteristics of these systems can be used. This article concerns the use of such an idealized fluid model of convective-scale NWP in inexpensive data assimilation (DA) experiments. The forecast model, introduced in Kent et al (2017), is a modification of the rotating shallow water equations that includes some simplified dynamics of cumulus convection and associated precipitation. It is of interest owing to (i) its distinctive dynamics, including the disruption of large-scale balanced flows, highly nonlinear behaviour associated with convection and moisture, and other features of convecting and precipitating weather systems, and (ii) its computational efficiency, a crucial factor for an idealized model. \nWhen using such intermediate-complexity models for DA research, it is important to justify their relevance in the context of NWP. \nThe process of achieving a well-tuned observing system and filter configuration is described here using a deterministic ensemble Kalman filter. The tuning process involves systematically permuting through parameters of the combined forecast-assimilation system, combinations of which define a single experiment. We conduct numerous experiments, each characterized by a specific combination of parameters pertaining to the filter configuration and observing system, and assess their performance and relevance objectively in a concise graphical manner. We show how to construct well-tuned experiments in which the ensemble provides a good estimate of the forecast error, assessed via a spread-error diagnostic and the Continuous Ranked Probability Score. The forecast-assimilation system has an average observational influence similar to operational NWP (about 30%) and the resulting error-doubling time statistics reflect those of operational convection-permitting models (about 6-9 hours). We supplement the objective assessment of performance and relevance with a subjective examination of model fields at different forecast lead times, illustrating the impact of data assimilation on the model dynamics and highlighting where improvements are both achieved and lacking. Our approach and results not only demonstrate the model's suitability for conducting DA experiments in the presence of convection and precipitation, but also offer a formative protocol for conducting data assimilation research in an idealized yet relevant framework.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":229377140,"openaccessinfo":{"externalids":{"MAG":"3111827978","ACL":null,"DOI":"10.31223\/x5ng6d","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/eartharxiv.org\/repository\/object\/1921\/download\/4029\/","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Mantanani Besar Island is located about 30 km from the nearest point of Kota \nBelud mainland. Increasing development and usage of its beach has proven that \nthe island is very important to the local community and has a high potential for a \ntourism destination. However, communities have stated that the island experienced \nbeach erosion especially during the peak northeast monsoon (NEM) and southwest \nmonsoon (SWM). Limitation of baseline data regarding shoreline changes and \nbeach erosion at the island leads to the objectives of this study which are to \ndetermine the long-term shoreline changes, evaluate beach morphologies (beach \nprofile, width, angle, slope condition and beach sediment volume) and sediment \ncharacteristics at different seasonal monsoons and as well as identification of \nerosion based on the communities observation and opinions. The island was divided \ninto four zones and five sampling stations (st) based on the cardinal direction. Zone \n1 located at the west (st 1), zone 2 at southern (st 2), zone 3 at eastern (st 3 and \n4) and zone 4 at northern (st 5) part of the island. Aerial photos (1986, 1990, 2001 \nand 2013) and satellite images (2010) of Mantanani Besar Island were used to \ndetect long-term changes by overlapping the images in ArcGIS 9.3 software. Field \ntrips for beach profile and sediments collection were done twice to represent NEM \nand SWM in 2013, 2014 and 2015. The beach morphologies calculations were \nbased on beach profiles data while collected sediment undergoes sand sieve \nanalysis to calculate the sediment mean, sorting, skewness and kurtosis. Interviews \nwith the community were done based on a structured questionnaire to assess the \nbeach erosion. Results show that the size of Mantanani Besar Island was decreased \nwith estimated total land loss of 170, 838 m\u00b2 since 1986. The highest land loss is \nlocated in zone 2 with 71, 590 m2 (43%) while zone 3 was the most dynamic area \nbased on the obvious changes on the maps and the highest occurrence of beach \nerosion and accretion (16 identified beach changes). The total average value of \nbeach morphologies was higher at the NEM than the SWM indicating accretion \nduring NEM and erosion during SWM. Mantanani Besar Island beaches dominated \nwith medium sand size with the excess of finer sediment whereas the exposures of \nenvironmental forces were medium with slightly higher in SWM. The sediment \nsorting was achieved through cross-shore (NEM) and longshore transport (SWM). \nCommunities observation and opinions were in line with the results of long-term \nshoreline changes where Mantanani Besar Island experienced beach erosion since \nthe past 20 years and it occurs at all zones (highest land loss at zone 2). Beach \nerosion has affected the residential areas in terms of properties destruction \nincluding personal and public properties with few uprooted trees. The local \ncommunities are aware of the continuous shoreline erosion and preferred to wait \nfor the government actions to protect the island. The findings of this study provide \nbaseline data (erosion and accretion area with beach dynamic during seasonal \nmonsoon) and can be utilized by community, tourist operators and government as \na guideline for future developments and integrated management plan of the island.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":134430618,"openaccessinfo":{"externalids":{"MAG":"2894997002","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Hermaphroditism is a mode of reproduction involving an individual animal that possesses both a testis and an ovary either sequentially or simultaneously. The mechanism creating hermaphrodites remains unknown. Previously, we identified foxl3 as the germline sex determination gene in a gonochoristic fish, medaka (Oryzias latipes). foxl3 loss-of-function (foxl3\u2212\/\u2212) females produce functional sperm as well as eggs in the ovary. However, these two gametes are not self-fertilizing because of the histological separation of each gamete production. In this study, we attempted to generate self-fertilizing medaka from female medaka by modifying germline sex using foxl3\u2212\/\u2212 mutants and by using exogenous androgen to induce partial sex reversal of somatic cells. Methods: foxl3\u2212\/\u2212 XX females were treated with 11-ketotestosterone (11-KT), a potent teleost fish androgen, at the sexually mature stage for 30 days (90\u2013120 dph). Then, the fish were kept under normal conditions until they were either being dissected or crossed with infertile males. Results and Discussion: We showed that the foxl3\u2212\/\u2212 XX female medaka can be transformed into a self-fertilizing hermaphrodite by inducing the formation of a male-like structure with exogenous 11-KT. Self-fertilization occurs in either the ovarian cavity, the oviduct, or both where sperm is released from a tubule-like structure which is likely derived from germinal epithelium, suggesting that timely modification of 2 independent mechanisms, regulation of germline sex and partial sex reversal of somatic cells, are critical to change the reproduction mode. Our results will provide insights in developmental and evolutional occurrence of hermaphrodite vertebrates, facilitate an innovative technique to improve the efficient selection of fish with desirable traits, and contribute to the rescue of endangered species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":254124834,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1159\/000526073","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"the rapidly increasing power of personal mobile devices (smartphones, tablets, etc.) is providing much richer contents and social interaction to users on the move. But the limited battery life time of mobile devices and unstable wireless connectivity make the highest possible quality of service experienced by mobile users not feasible. The recent cloud computing technology with its rich resource to compensate for the limitation of mobile devices and connections can potentially provide an ideal platform to support the desired mobile services. Tough challenges arise on how to effectively exploit cloud resource to facilitate mobile services, especially those with stringent interaction delay requirements. This paper aims to design a novel mobile social TV system, which can effectively utilize the cloud computing paradigm to offer a living room experience of video watching for desperate mobile users with spontaneous social interaction. It also takes into consideration the battery efficient, portable and transcoding capabilities. Voice chat, use of peer-to-peer technology and video compression are salient features. It makes use of PaaS (Platform-as-a- Service) and IaaS (Information-as-a-Service) cloud.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110817463,"openaccessinfo":{"externalids":{"MAG":"2186445667","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: The improvement in healthcare services and life expectancy, and also decrease in fertility rate, leads to an exponential increase in elderly population. The attitude of healthcare workers has to change with this increase as they will be encountering more aged clients in future. Research has shown that health care workers and undergraduate health care students have negatively preconceived ideas about the elderly leading to unfavourable attitude towards them. Aims and objectives: To determine the factors associated with attitude towards the elderly among Medical and Nursing students in Universiti Putra Malaysia. Method: A cross-sectional study was carried out using proportional stratified sampling, involving 456 medical students and 63 nursing students. The selection of the respondents was done by simple random sampling method using guided self-administered questionnaire distributed to year 1 to year 5 medical students and year 1 to year 3 nursing students from the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. The questionnaire was pre-tested and validated prior to its use and consisted of 6 sections; socio-demographic characteristics, modified Kogan's Attitude Towards Old People Scale (ATOP), modified Facts on Ageing Quiz 2 (FAQ2), modified filial responsibility questionnaire, experience of living with elderly questions as well as questions on exposure to geriatric module. Three level of analyses were conducted which are descriptive analysis, chi-square and logistic regression. The significance level was set at 0.05. Results: A total of 519 respondents were involved in the study with 91.4% response rate. It was observed that 52.0% of the respondents had negative attitude towards the elderly, 70.3% had good knowledge of ageing, only 29.7% were currently living with the elderly. Meanwhile 74.0% have ever lived with the elderly, 53.0% had low perceived filial responsibility, and 54.1% had no exposure to geriatric module. There were significant associations between attitude towards elderly people and year of study (X2=12.699, p= 0.013), and also perceived filial responsibility X2 =44.599, p = 0.001). However, only perceived filial responsibility was the significant predicting factor for attitude towards the elderly (AOR=2.957, p = 0.001, 95% CI=1.999-4.372), in which those with high perceived filial responsibility had 3 times higher odds of having positive attitude towards the elderly than those who had low perceived filial responsibility However, the model only explains 12.4% of the variation in positive attitude towards the elderly (Negelkerke's R2 = 0.124) Conclusion: The findings of the study revealed that slightly more than half of the medical and nursing students in Universiti Putra Malaysia have negative attitude towards the elderly and perceived filial responsibility is the only predictor of attitude towards the elderly. In view of the upsurge in elderly population and an important role play by the healthcare workers in the care of elderly people, it is suggested that the importance of filial responsibility be more emphasized and embedded in the geriatric curriculum of medical and nursing students at every stage of their training. Keywords: attitude, knowledge of ageing, perceived filial responsibility, exposure to geriatric module, elderly.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":217335090,"openaccessinfo":{"externalids":{"MAG":"2996127494","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nAn outbreak of disease on the cultured Miichthys miiuy occurred in Zhoushan of Zhejiang province. The symptom displayed as skin ulceration and the inside apparatus turned white.\n\n\nMETHODS\nWe isolated a dominant bacterial strain from the diseased Miichthys and assigned it as strain 090212. The artificial infection test proved that the isolate 090212 was the pathogenic bacterium that caused the disease. We applied physiological and biochemical characterization and API system in the bacterial classification. In order to confirm the result, we amplified a 1458bp sequence of 090212' s 16S rDNA and compared with other Vibrio in GenBank.\n\n\nRESULTS\nThe results turned out that 090212 was Gram negative and short rod with single polar flagellum. Homology analysis and phylogenetic study showed that strain 090212 had the highest similarity to Vibrio harveyi, with 99% identity. The sensitivity test of strain 090212 to 28 kinds of antibiotics revealed that the pathogen was sensitive to drugs such as Florfenicol and Tetracycline.\n\n\nCONCLUSION\nThis paper revealed for the first time that the causative pathogen, Vibrio harveyi, lead to the mass mortality of Miichthys, which will be helpful in the disease control and health management during Miichthys cultivation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38396956,"openaccessinfo":{"externalids":{"MAG":"2418359259","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Finding a good learning path with respect to existing reference paths of closely related concepts is very challenging yet important for effective course teaching and especially adaptive e-learning systems. There are various approaches including ontology analysis to extract the key concepts which could then be correlated to one another using an implicit or explicit knowledge structure for relevant courses. With the available correlation information, an effective optimizer can ultimately return a good learning path according to its predefined objective function. In this paper, we propose to obtain more thorough correlation information through concept clustering, which will then be passed to our rule-based genetic algorithm to search for better learning path(s). To demonstrate the feasibility of our proposal, a prototype of our ontology analyser enhanced with concept clustering and rule-based optimizer was implemented. Its performance was thoroughly studied and compared favorably against the benchmarking shortest-path optimizer on actual courses. More importantly, our proposal can be easily integrated into existing e-learning systems, and has significant impacts for adaptive or personalized e-learning systems through enhanced ontology analysis.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":25095569,"openaccessinfo":{"externalids":{"MAG":"2108859562","ACL":null,"DOI":"10.1109\/ICALT.2011.78","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In recent three decades the medicinal plant Gentiana dahurica Fischer has been threatened by large scale exploitation for trade and land-use practices, such as over-grazing and reclamation. However, research into the population ecology and sustainable use of this highly-threatened medicinal plant is lacking, and so we analyzed the effects of different litter applications and seed positioning (surface-sown or buried) as part of a program to rehabilitate it. The results indicated that although litter and seed position per se had no significant effects on the seedling emergence of G. dahurica , interestingly, litter application did show positive effects on seedling survival, e.g. 100 g m -2 and 200 g m -2 litter increased it by 9.7% and 16.4%, respectively, compared to control. Moreover, the seedling leaf area increased with the quantity of applied litter when seeds were surface-sown, with the highest leaf area occurring in the 200 g m -2 treatment (9.7-fold of the control), and litter-covered treatments also significantly improved seedling root length and root diameter of G. dahurica compared to controls. Taken together, these data indicated that seedling establishment of G. dahurica benefited from accumulated litter, and it is thus suggested that fencing to exclude grazing for a period is the best method to protect and rehabilitate the threatened wild G. dahurica populations.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":59585098,"openaccessinfo":{"externalids":{"MAG":"2028532775","ACL":null,"DOI":"10.5539\/JPS.V2N2P28","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : Early military applications of space-based assets bore little resemblance to their successful use in \"the first information war.\" The US developed most of its early space systems to serve the Cold War nuclear deterrence strategy. The need to protect space sources and methods resulted in a high degree of secrecy and organizational compartmentalization. As a result, when Desert Shield began the highly fragmented leadership of the space community lacked coherent doctrine, operated with an inherited top-down \"technology push\" for system requirements, and had little spacepower experience. Spacepower was simply unprepared to support the theater Commander-in-Chief in other than the Cold War strategic role. The experiences of the Persian gulf War confirmed these characteristics-the majority of the documented lessons concerned a lack of doctrine or a lack of space literacy\/experience. In the development of spacepower, doctrine and experience have evolved much more slowly than the pace of technology. In the interim, have the US participants redressed the imbalance that existed in the development of spacepower as witnessed in Operation Desert Shield\/Storm? At issue for space policy makers is the question of whether or not reform in technology, experience, or doctrine will move the US Military Space Program toward a more robust warfighting capability.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":106521280,"openaccessinfo":{"externalids":{"MAG":"1494518253","ACL":null,"DOI":"10.21236\/ada329263","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.dtic.mil\/dtic\/tr\/fulltext\/u2\/a329263.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Wild ancestors of common wheat (Triticum aestivum L.) have been reported to have higher maximum photosynthetic rates than modern wheat cultivars. Synthetic hexaploids, obtained by crossing tetraploid wheat and Aegilops tauschii Coss., have proven useful as a source of resistance or tolerance to biotic and abiotic stresses. This study was conducted to determine whether synthetic hexaploids also could contribute genetic diversity to enhance leaf photosynthetic rate and other physiological traits. Three different populations of BC 2 F 2 , synthetic-derived lines were evaluated at the Agricultural Research ('enter for the Northwest (INIFAP) Experimental Station, near Ciudad Obregon, Sonora, Mexico. Differences in maximum photosynthetic rate were detected among genotypes. Several synthetic-derived lines showed higher photosynthetic rates than their recurrent parent. Staygreen. determined as days between senescence and physiological maturity, of most synthetic-derived lines did not differ from the recurrent parents. Maximum photosynthetic rate was negatively associated with leaf area and positively associated with stomatal and mesophyll conductances, and leaf temperature depression. Mesophyll conductance accounted for 85% of the variation in maximum photosynthetic rate. These results suggest that synthetic-derived wheat can be also a source of genetic diversity for important physiological traits such as enhanced photosynthetic rate.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":83730857,"openaccessinfo":{"externalids":{"MAG":"1970057318","ACL":null,"DOI":"10.2135\/CROPSCI2000.4051257X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Radar Altimeter Database System project is part of the Netherlands Earth Observation NETwork (NEONET), an Internet facility, funded by the Dutch government, for exploitation of remote-sensing expertise and data (http:\/\/www.neonet.nl). In the frame of RADS, The Delft Institute for Earth-Oriented Space Research DEOS is building a data base that contains validated and verified altimeter data products that are consistent in accuracy, format, correction and reference system parameters. The availability of such a data base will attract users with less altimetry expertise like advisory councils, water management authorities and even high schools. Much effort has been put in calibrating and validating the raw data, i.e. harmonization of geophysical corrections, of secondary data, and of the measurements themselves. The validation includes editing, tide experiments, radiometer-model collocation, and Rossby and Kelvin waves propagation analysis. This paper introduces RADS, and deals with cal\/val aspects and how to use\/access the data.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":62149622,"openaccessinfo":{"externalids":{"MAG":"2107775076","ACL":null,"DOI":"10.1109\/IGARSS.2000.861605","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Embedding is one of the fundamental building blocks for data analysis tasks. Although most embedding schemes are designed to be domain-specific, they have been recently extended to represent various other research domains. However, there are relatively few discussions on analyzing these generated embeddings, and removing undesired features from the embedding. In this paper, we first propose an innovative embedding analyzing method that quantitatively measures the features in the embedding data. We then propose an unsupervised method to remove or alleviate undesired features in the embedding by applying Domain Adversarial Network (DAN). Our empirical results demonstrate that the proposed algorithm has good performance on both industry and natural language processing benchmark datasets.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204509217,"openaccessinfo":{"externalids":{"MAG":"2979451301","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Silicon tetrafluoride (SiF4) and sulfur hexafluoride (SF6) are widely used as sensitizing agents in photochemical experiments in the infrared region of the spectrum. These experiments include chemical vapor deposition, powder formation (for a review see Ref. 1), and kinetics. The energy of the Si-F bond is 610 kJ mol-1, whereas that of the corresponding S-F bond is 300 kJ mol-1. Therefore, SiF4 is expected to be a more versatile sensitizing agent than SF6, since the relatively high Si-F bond energy allows for greater radiative energy input and higher effective reaction temperatures. The high effective temperatures attained with the use of SiF4 (or SF6) necessitate the study of the absorptivities of these materials, since that quantity is known to be temperature dependent. Unfortunately, although some experimental results have been reported for SF6, such data are not generally available for SiF4. Moreover, in the case of laser-excited experiments, there is the potential for photochemical bleaching. Again, such data have been obtained for SF6, but only a limited amount of information is available for SiF4. In this study, we report on the absorptivity as a function of sample pressure (temperature) and as a function the continuous-wave (cw) laser power for conditions typically employed in sensitized infrared-driven chemical processes. It may be readily observed from the presented data that the absorptivity decreases with increasing laser power and that a limiting temperature is reached for increasing sample pressure at a constant laser power.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2015-11":1,"2015-06":1,"2015-18":1}},"corpusid":95933786,"openaccessinfo":{"externalids":{"MAG":"2012428953","ACL":null,"DOI":"10.1366\/0003702963906285","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A self-commutated AC\/DC converter composed of controlled turn-off devices to be applied to future system interconnection is described. The advantages of a control system for this type of converter are: (1) commutation does not fail when the system voltage is decreased or distorted by a power system fault; (2) it needs no equipment for reactive power supply, such as static capacitors or synchronous rotating condensers, when used in a low short-circuit capacity power system; and (3) it can independently control active power through DC lines and reactive power from each terminal. The proposed back-to-back (BTB) control system using the voltage margin method was verified with a simulator, and the results demonstrated the excellent features of the high-performance self-commutated converter.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110880253,"openaccessinfo":{"externalids":{"MAG":"2063587316","ACL":null,"DOI":"10.1109\/61.660882","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"New embedded systems must be power-aware, not just low-power. That is, they must track their power sources and the changing power and performance constraints imposed by the environment. Moreover, they must fully explore and integrate many novel power management techniques. Unfortunately, these techniques are often incompatible with each other due to overspecialized formulations or they fail to consider system-wide issues. This paper proposes a new graph-based model to integrate novel power management techniques and facilitate design-space exploration of power-aware embedded systems. It captures min\/max timing and min\/max power constraints on computation and non-computation tasks through a new constraint classification and enables derivation of flexible system-level schedules. We demonstrate the effectiveness of this model with a power-aware scheduler on real mission-critical applications. Experimental results show that our automated techniques can improve performance and reduce energy cost simultaneously. The application model and scheduling tool presented in this paper form the basis of the IMPACCT system-level framework that will enable designers to aggressively explore many power-performance tradeoffs with confidence.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":3}},"corpusid":894781,"openaccessinfo":{"externalids":{"MAG":"2129387798","ACL":null,"DOI":"10.1109\/HSC.2001.924667","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Brown rot caused by Monilinia spp. (anamorph Monilia) is a common disease in stone fruits worldwide, but the species in different hosts or regions may vary. Monilia mumecola is a recently identified species, only reported in some regions. Although the pathogen has been found on plum in Yunnan, Hubei, and Zhejiang provinces, and Chongqing municipality in China (Yin et al. 2015), it has not been reported in southeast coast of China. In May 2022, brown rot with grey spores on fruit was observed in a plum orchard with 15% disease incidence in Sanming City, Fujian Province, located in southeast coast of China. Four single-spored isolates were obtained from germinating conidia on the water agar for further investigation. The colonies on potato dextrose agar (PDA) were initially white, gradually turned gray to brown, with lobbed margins and rare sporulation. Average mycelial growth rate ranged from 0.74 to 1.08 cm\/day at 25 oC. Conidia were lemon-shaped or subglobose, hyaline, with an average size of 17.64 to 19.35\u00d711.14 to 14.44 \u03bcm (n=30). Each isolate produced one to three or four germ tubes. Such characteristics are similar to M. mumecola (Yin et al. 2015). To confirm the identity of the isolates, genomic DNA was extracted and species-specific primers of Hu et al. (2011) were used to amplify the 712 bp sequence. In addition, the ITS region, partial genes of glyceraldehyde-3- phosphate dehydrogenase (GAPDH) and beta-tubulin (TUB2) were also amplified using primers sets ITS1\/ITS4 (Glass and Donaldson 1995), Mon-G3pdhF\/Mon-G3pdhR and Mon-TubF1\/ Mon-TubR1, respectively (Hu et al. 2011). Sequences obtained for those three regions were 478, 762 and 1527 bp, respectively. Each region of all four isolates was identical, so one sequence for each region was submitted to GenBank with accession numbers OQ207672, OQ225251 and OQ225252, respectively, which had 100% identity with M. mumecola HQ908786 (ITS), HQ908784 (GAPDH), and HQ908775 (TUB2) using BLAST analysis in NCBI database, respectively. Pathogenicity was conducted with mycelium plugs from the edge of 7-day-old colony on three mature 'Angeleno' plums fruit (Prunus salicina) creating nine inoculations with three wounds per fruit, and each wound was 5 mm in diameter and 2 mm in depth. The same amount fruit and wounds inoculated with PDA plugs without fungi were used as a control. Brown rot symptoms were observed on all inoculated plums 4 days post-inoculation under room temperature with 100% humidity, whereas control plums remained symptomless. Fungal colonies re-isolated from the lesions showed the same morphological features as the original isolate , thus fulfilling Koch's postulates. To our knowledge, this is the first report of M. mumecola on plum in Fujian Province of China. The findings in this studies have important management implications for local plum growers because more than one Monilia species have been reported, where only M. fructicola was present in this region.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257773054,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1094\/PDIS-01-23-0127-PDN","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper two common 3D flexible processing methods using high power laser are introduced. One is high power YAG laser robot which use fiber to propagate laser beam. The robot holds laser head to move along spatial route on the surface of 3D part. The movement of robot influences laser processing result. Another is CO2 laser multi-axis system which uses mirrors to transfer laser beam. The quality of laser beam has great effect on propagation of laser beam and therefore influences laser processing quality. In these systems the programming is key to process 3D part. Currently the low efficient on-line teach-in programming is mainly used in these systems. Authors introduce their own developed high efficient off-line auto programming software for 3D laser processing---LaserCAM. The LaserCAM software in auto manufacture in China has been successfully applied.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":111281354,"openaccessinfo":{"externalids":{"MAG":"2082944427","ACL":null,"DOI":"10.1117\/12.482894","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Acetylation is an important, highly conserved, and reversible post-translational modification of proteins. Previously, we showed by nano-HPLC\/MS\/MS that many nutrient storage proteins in the silkworm are acetylated. Among these proteins, most of the known 30K proteins were shown to be acetylated, including 23 acetylated 30K proteins containing 49 acetylated sites (Kac), indicating the importance of the acetylation of 30K proteins in silkworm. In this study, Bm30K-3, a 30K protein containing three Kac sites, was further assessed in functional studies of its acetylation. Increasing the level of Bm30K-3 acetylation by adding the deacetylase inhibitor trichostatin A (TSA) increased the levels of this protein and further inhibited cellular apoptosis induced by H2 O2 . In contrast, decreasing the level of acetylation by adding the acetylase inhibitor C646 could reduce the level of Bm30K-3 and increase H2 O2 -induced apoptosis. Subsequently, BmN cells were treated with CHX and MG132, and increasing the acetylation level using TSA was shown to inhibit protein degradation and improve the stability of Bm30K-3. Furthermore, the acetylation of Bm30K-3 could compete with its ability to be ubiquitinated, suggesting that acetylation could inhibit the ubiquitin-mediated proteasome degradation pathway, improving the stability and accumulation of proteins in cells. These results further indicate that acetylation might regulate nutrition storage and utilization in Bombyx mori, which requires further study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208335502,"openaccessinfo":{"externalids":{"MAG":"2990052447","ACL":null,"DOI":"10.1002\/arch.21649","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background AK106-001616 (AK106) is a selective cytosolic phospholipase A2 (cPLA2) inhibitor with a novel mechanism of action as an anti-inflammatory\/analgesic drug. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), AK106 inhibits the production of arachidonic acid, the source of inflammatory lipid mediators including prostaglandins (PGs) and leukotrienes (LTs). Inhibition of PGs has been shown to improve the symptoms of rheumatoid arthritis (RA), other chronic inflammatory and pain indications, and the further inhibition of LTs is expected to enhance this effect. Methods This was a phase IIa, multi-centre study with a randomised, double-blind, triple-dummy, 3-arm, parallel-group, comparator-controlled, repeated-dose design. The study investigated\/compared the efficacy, safety, PK and PD of 2 dose levels (100 mg bid and 600 mg bid) of AK106 in patients with active RA to that of naproxen 500 mg bid over a 28 day treatment period. Patients were required to be on background MTX and were randomly assigned to one of the 3 treatment arms. Video capsule endoscopy (VCE) assessment was performed as an optional assessment on Day -1 and Day 29 to investigate the effects of AK106 on the small bowel. Results A total of 253 patients were randomised and 230 patients completed the 28 day treatment. Patient baseline characteristics were well balanced among the 3 treatment groups. Mean changes in patient assessment of arthritis pain (VAS) from baseline to Day 28 were \u221218.3 mm in the 100 mg group, \u221215.9 mm in the 600 mg group and \u221216.7 mm in the naproxen group. ACR20 response was achieved at Day 28 in 49.4% subjects in the 100 mg group, 47.6% subjects in the 600 mg group and 49.4% subjects in the naproxen group. In terms of the other efficacy variables, AK106 was as effective as naproxen in both the 100 mg and 600 mg groups. The overall incidence of treatment-emergent adverse events (TEAEs) for the 100 mg group was comparable to that for the naproxen group. The incidence of GI related TEAEs in the 100 mg group was slightly lower than the naproxen group. However, the incidence of TEAEs and GI related TEAEs for the 600 mg group was higher. One treatment-emergent serious adverse event was reported in 1 patient in the 600 mg group, and was regarded as unrelated to the study drug. The results of the optional VCE assessment in the small bowel showed that the 100 mg group demonstrated no change from baseline in the mean number of mucosal breaks without haemorrhage however there was a significant increase on Day 29 compared to baseline in the naproxen group (p=0.014, AK106 100 mg vs naproxen). The results for the 600 mg group were similar to those for the naproxen group. Results of the PD marker measurements demonstrated that as expected, while the production of PGs was inhibited by both AK106 and naproxen, the production of LTs was inhibited only by AK106. Conclusions AK106 was efficacious and well tolerated by patients with RA. The incidence of GI related TEAEs and the significant results of the optional VCE assessment in the 100 mg group suggest that AK106 has a better GI profile compared to naproxen. These results suggest that AK106 may have a role in the treatment of RA patients. Disclosure of Interest None Declared","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":76016932,"openaccessinfo":{"externalids":{"MAG":"2326331029","ACL":null,"DOI":"10.1136\/annrheumdis-2013-eular.751","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nInitial goal directed resuscitation for shock usually includes the administration of intravenous fluids, followed by initiating vasopressors. Despite obvious immediate effects of vasopressors on haemodynamics their effect on patient relevant outcomes remains controversial. This review was originally published in 2004 and was updated in 2011.\n\n\nOBJECTIVES\nOur primary objective was to assess whether particular vasopressors reduce overall mortality, morbidity, and health-related quality of life.\n\n\nSEARCH STRATEGY\nWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 2), MEDLINE, EMBASE, PASCAL BioMed, CINAHL, BIOSIS, and PsycINFO (from inception to March 2010). The original search was performed in November 2003. We also asked experts in the field and searched meta-registries for ongoing trials.\n\n\nSELECTION CRITERIA\nRandomized controlled trials comparing various vasopressor regimens for hypotensive shock.\n\n\nDATA COLLECTION AND ANALYSIS\nTwo authors abstracted data independently. Disagreement between the authors was discussed and resolved with a third author. We used a random-effects model for combining quantitative data.\n\n\nMAIN RESULTS\nWe identified 23 randomized controlled trials involving 3212 patients, with 1629 mortality outcomes. Six different vasopressors, alone or in combination, were studied in 11 different comparisons.All 23 studies reported mortality outcomes; length of stay was reported in nine studies. Other morbidity outcomes were reported in a variable and heterogeneous way. No data were available on quality of life or anxiety and depression outcomes. We classified 10 studies as being at low risk of bias for the primary outcome mortality; only four studies fulfilled all trial quality items.In summary, there was no difference in mortality in any of the comparisons between different vasopressors or combinations. More arrhythmias were observed in patients treated with dopamine compared to norepinephrine. Norepinephrine versus dopamine, as the largest comparison in 1400 patients from six trials, yielded almost equivalence (RR 0.95, 95% confidence interval 0.87 to 1.03). Vasopressors used as add-on therapy in comparison to placebo were not effective either. These findings were consistent among the few large studies as well as in studies with different levels of within-study bias risk.\n\n\nAUTHORS' CONCLUSIONS\nThere is some evidence of no difference in mortality between norepinephrine and dopamine. Dopamine appeared to increase the risk for arrhythmia. There is not sufficient evidence of any difference between any of the six vasopressors examined. Probably the choice of vasopressors in patients with shock does not influence the outcome, rather than any vasoactive effect per se. There is not sufficient evidence that any one of the investigated vasopressors is clearly superior over others.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30333731,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/14651858.CD003709.pub3","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The concept of uniform interpolant for a quantifier-free formula from a given\nformula with a list of symbols, while well-known in the logic literature, has\nbeen unknown to the formal methods and automated reasoning community for a long\ntime. This concept is precisely defined. Two algorithms for computing\nquantifier-free uniform interpolants in the theory of equality over\nuninterpreted symbols (EUF) endowed with a list of symbols to be eliminated are\nproposed. The first algorithm is non-deterministic and generates a uniform\ninterpolant expressed as a disjunction of conjunctions of literals, whereas the\nsecond algorithm gives a compact representation of a uniform interpolant as a\nconjunction of Horn clauses. Both algorithms exploit efficient dedicated DAG\nrepresentations of terms. Correctness and completeness proofs are supplied,\nusing arguments combining rewrite techniques with model theory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":239998394,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.46298\/lmcs-18(2:2)2022","PubMedCentral":null,"ArXiv":"2002.09784"},"license":"CCBY","url":"https:\/\/lmcs.episciences.org\/9354\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"SUMMARY Cotton\u2013wheat (CW) is an important cropping system in South Asia. Wheat yields under a conventional CW system are generally lower compared to a rice\u2013wheat system due to delayed seeding. Relay seeding of wheat can help timely sowing, capturing residual soil moisture of last irrigation to cotton, and increase the productivity and profitability of CW system. The field experiment included two Bt-cotton genotypes having different canopy cover (RCH 776 and MRC 7017), two types of relay seeders (RSs) for cotton planted at 67.5-cm and 101-cm row spacing and four types of relay seeding methods (manual broadcast, strip rotor (SR) and zero-till double disc and conventional till). Relay planting of wheat allowed one additional boll picking, which increased seed cotton yield by 12% compared with conventional tillage wheat. Cotton genotypes and RSs had no effect on emergence and yield of wheat. The RSs with SR and zero till double disc furrow openers performed better in terms of wheat emergence and grain yield compared to zero-till tine openers. Under relay seeding, wheat sowing was advanced by 31 days, which increased grain yield by 18.8% compared with conventional tillage practice. Net returns from the CW system with relay seeding of wheat were higher by US$ 311 to 425 ha\u22121 compared with the conventional CW system.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":89190966,"openaccessinfo":{"externalids":{"MAG":"2519577753","ACL":null,"DOI":"10.1017\/S0014479716000569","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Despite great successes in oncology, patient outcomes are often still discouraging, and hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of the pathology to better understand individual disease biology and to personalize therapies. The dissolution Dynamic Nuclear Polarization (d-DNP) hyperpolarization method has enabled unprecedented real-time MRI sensing of metabolism and tissue pH using hyperpolarized [1-13C]pyruvate as a biosensor with great potential for diagnosis and monitoring of cancer patients. However, current d-DNP is expensive and suffers from long hyperpolarization times, posing a substantial translational roadblock. Here, we report the development of Re-Dissolution Signal Amplification By Reversible Exchange (Re-D SABRE), which relies on fast and low-cost hyperpolarization of [1-13C]pyruvate by chemical exchange with parahydrogen at microtesla magnetic fields. [1-13C]pyruvate is precipitated from catalyst-containing methanol using ethyl acetate and rapidly reconstituted in aqueous media. 13C polarization of 9 \u00b1 1% is demonstrated after redissolution in water with residual iridium mass fraction of 8.5 \u00b1 1.5 ppm; further improvement is anticipated via process automation. Re-D SABRE makes hyperpolarized [1-13C]pyruvate biosensor available at a fraction of the cost (<$10,000) and production time (\u22481 min) of currently used techniques and makes aqueous hyperpolarized [1-13C]pyruvate \"ready\" for in vivo applications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253551420,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acssensors.2c01715","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Today, the introduction of ceramic materials in the medical field is becoming a vital necessity because of its stable physicochemical characteristics, high biocompatibility, and good osteoconductivity. On the other hand, machining of ceramic components is difficult, owing to their extreme hardness and brittleness. Additive Manufacturing (AM) technologies are an appropriate alternative to obtain the complex shapes of implants, which can have porous structures. Thus, since the development of 3D printing, Direct Ink Writing (DIW) is one of the most promising and inexpensive techniques for shaping free-form ceramic medical components such as prostheses or dental implants from liquids or pastes. However, the assurance of performance criteria of the extrusion system for simultaneous usage becomes the major challenge for most Direct Ink Writing (DIW) platforms, for instance for printing large parts, for multi-material printing, to decrease printing time, and to increase efficiency in terms of motor usage and weight of the extruders. To address the current deficiencies, a new extrusion system is redesigned for a 3D printing machine for ceramics that is compatible with different low-cost, open-source 3D printers. The proposed extrusion model enables printing with a loader with different syringes simultaneously, without stopping the operational process while switching the syringe. Pugh concept analysis was used to select the optimum design shape. After that, the 3D CAD environment was used to combine the strength of Pugh's method and the design space. This brings a new concept into the mechanical design field for 3D printers, which is in line with the technological trends prevalent in industry.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233835283,"openaccessinfo":{"externalids":{"MAG":"3133499617","ACL":null,"DOI":"10.21203\/RS.3.RS-265668\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An immunohistological study was performed on allergic (A) and non-allergic (NA) nasal mucosa to examine the profiles of infiltrating T-lymphocytes and their association with the expression of ICAM-1. Higher numbers of CD4 and CD45RO positive cells were detected in the A group than in the NA group, especially in the superficial portion of the lamina propria (SUP), whereas the number of CD8 positive cells was the same in the two groups. ICAM-1 was noted mainly on the vascular endothelium and on the infiltrating cells in the SUP, and there was no difference in the intensity of its expression between the A and NA groups. However, the infiltration of CD4 and CD45RO positive cells in the SUP and around the glands was significantly greater in patients with intense ICAM-1 expression in the A group. The infiltration of CD8 positive cells did not differ among the patient groups with different intensities of ICAM-1 expression in the A and NA groups.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21441501,"openaccessinfo":{"externalids":{"MAG":"2092188977","ACL":null,"DOI":"10.3109\/00016489409126063","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective. To determine the compliance rate for treatment recommendations consistent with expectant management of inner-city men with prostate cancer. Methods. Twenty-seven out of 560 men who underwent biopsy of the prostate were found to harbor cancer and opted for expectant management. Clinic and hospital records were reviewed for adherence to follow-up schema. Results. Of the 27 men on expectant management, 22 men (82%) adhered to strict follow-up schema. At 6-month follow-up, there were no significant changes in clinicopathologic features (e.g., prostate specific antigen (PSA), Gleason score, and stage). With a median follow-up of 12 months, only 2 men demonstrated a rise of more than 30% from baseline PSA (repeat biopsy demonstrated persistent low grade, low stage disease). Conclusions. Our findings imply that expectant management may be feasible in inner-city settings. Thus, in subsequent expectant management trials, inner-city men should be actively recruited.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":37784926,"openaccessinfo":{"externalids":{"MAG":"2047188656","ACL":null,"DOI":"10.1353\/hpu.2008.0024","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"III. On the fate of persons suffering of fungus diseases in areas or countries where the physicians lack training in medical mycology, or where there is a want of adequately equipped laboratories to permit satisfactory diagnoses","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10288948,"openaccessinfo":{"externalids":{"MAG":"2111431920","ACL":null,"DOI":"10.1111\/J.1439-0507.1968.TB03342.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A pot culture experiment was conducted at Indian Institute of Soil Science to compare the nutrient uptake pattern of rainy season crops such as maize, soybean, sorghum, pearl millet, finger millet and rice. Crop biomass was taken at 30, 50, 75 and 90 days after sowing (DAS) and at maturity from each crop. Among the crops grown, total dry biomass was decreasing in the following order; maize > pearl millet > sorghum > soybean> rice > finger millet. With respect to nutrient uptake, soybean crop showed highest nitrogen (N) content in shoot (1.73%), followed by maize (1.12%), pearl millet (1.10%), finger millet and rice (0.79%) and sorghum (0.78%), whereas, maximum phosphorus (P) concentration was in maize followed by pearl millet and sorghum. Micronutrient concentration was more in shoot as compared to roots in all crops except soybean. This study might be useful in the bio-fortification process for fodder purpose. Higher biomass producing maize crop with higher nutrient uptake capacity can be used for agronomic biofortification. It will help for reducing nutritional deficiency in animals. \n \n Key words: Biomass, nutrient uptake, soil fertility.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":130264778,"openaccessinfo":{"externalids":{"MAG":"2144187926","ACL":null,"DOI":"10.5897\/AJAR2013.7969","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 6-year-old stallion was placed in a pasture for 9 days with 20 mares in which oestrus was synchronized with two treatments of PGF-2 alpha given 15 days apart. Breeding and observation began 3 days after the second treatment. Observations were carried out during the daylight hours (05:00 to 21:30 h). Eighteen mares showed oestrus and mated an average of 4.56 times each (range 1-12). There were 1.74 mounts per mating. The maximum number of matings by the stallion during 1 day was 16 on Day 2. The overall mean interval between matings was 72.8 min, ranging from 34.5 min on Day 1 to 128.7 on Day 6. The mares were mated at irregular intervals during oestrus but 16 of 18 (88.9%) mares mated at least once during the 3 days preceding the last day of oestrus. Only 5 mares mated on the last day of oestrus. Of the 20 mares, 17 (85%) were pregnant when examined 38 days after the end of the experiment. The results suggest that a stallion will indulge in significantly more mating activity at pasture than is currently expected with hand mating and still achieve a high first oestrus conception rate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20620693,"openaccessinfo":{"externalids":{"MAG":"2416535734","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on Atmel Corporation's microcontroller ATmega16L and ultrasonic sensor TCT40-16F, designs an ultrasonic measurement and alarm system with high precision. Using the method of MJ echo capture, the system can realize measuring the distance well and truly, and can send the real time distance data to the LCD screen of system. Once the distance was less than the setting value, the system would alarm immediately. In addition, the system uses temperature sensor for temperature compensation, which effectively improves the ranging accuracy. Experimental results show that the system has high range accuracy, and can complete the distance task of reversing radar, and has high value and broad application prospects.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-20":1,"2015-06":1,"unknown":2}},"corpusid":35017744,"openaccessinfo":{"externalids":{"MAG":"1998312958","ACL":null,"DOI":"10.1109\/CSIP.2012.6308798","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Medication noncompliance has a significant effect on morbidity, mortality, and ease of living in diabetic patients. Non-compliance may be associated with patient demographics, the complexity of the drug regimen, dosage frequency, adverse effects, or some combination of these. Aim: To study the prevalence of treatment non-compliance among elderly diabetic patients in Majmaah, KSA. Method: A cross-sectional questionnaire-based study among elderly patients registered with the primary health center in Majmaah, Saudi Arabia. Results: Patients with a neutral attitude towards the disease and some knowledge of diabetes were more likely to be non \u2013 compliant with their treatment than those who do not have any knowledge of diabetes or with a positive\/negative attitude. Conclusion: A high prevalence of non \u2013 compliance is still a problem in the treatment of elderly diabetic patients, particularly those who had positive risk factors. Further studies are needed to reduce noncompliance through various ways and means.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":249371370,"openaccessinfo":{"externalids":{"MAG":"3010493298","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Changes in the structure of oribatid mite communities were studied at six urban sites located in Bratislava, Slovakia (Central Europe). These differed in pattern and in the intensity of human impact. Soil samples were taken from each site at monthly intervals for a period of two years. A total of 139 species were identified, of which 64.8% occurred at the control site. Low numbers of species (18\u201326 spp.) were found at sites characterized by high anthropogenic pressure. The percentage of oribatid mites in acarocoenoses declined (in favour of other mite groups) at sites altered from their original biotope and influenced by permanent human intervention (from 70% to less than 25%). The highest abundance of mites (976.9 ind.\/dm2) was recorded at an urban site, where the oribatid mite percentage was only 21.2%. Species typical of wet forest and meadow habitats were found at sites with suburban and ruderal characteristics, where vegetation cover attenuates the heat island effect, whereas mainly xerothermophilous and eurypotent species formed oribatocoenoses in urban sites. Urban conditions resulted in distinctly lower values of diversity, species richness, and equitability. The species Epilohmannia cylindrica, Microppia minus, Oribatula tibialis, Protoribates capucinus, Rhysotritia ardua and Ramusella insculpta common in the European cities were recorded also in this study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53713899,"openaccessinfo":{"externalids":{"MAG":"2901000983","ACL":null,"DOI":"10.2478\/s11756-018-0156-9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper introduces a data-driven, transparent and unbiased method to calculate the economic costs of the Brexit vote in June 2016. We let a matching algorithm determine a combination of comparison economies that best resembles the growth path of the UK economy before the Brexit referendum. The economic cost of the Brexit vote is the difference in output between the UK economy and and its synthetic doppelganger. We show that, contrary to public perception, by the third quarter of 2017 the economic costs of the Brexit vote are already 1.3% of GDP. The cumulative costs amount to almost 20 billion pounds and are expected to grow to more than 60 billion pounds by end-2018. We provide evidence that heightened policy uncertainty has already taken a toll on investment and consumption.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":146803201,"openaccessinfo":{"externalids":{"MAG":"2775812795","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In non-secernent plasmocytomas there are no characteristic changes of serum protein. Diagnostic difficulties may be overcome by cytomorphological examinations, immunofluorescence and electron microscopy. By referring to 4 own observations the value of the electron microscopic characteristics of plasma cells is demonstrated. Subtile investigations in protein diagnostics are required for avoiding incomplete monoclonal immunoglobulins which may greatly enter the kidneys to be overlooked. Generally the prognosis of non-secernent plasmocytomas is not worse than that of other forms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23529446,"openaccessinfo":{"externalids":{"MAG":"2397580361","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background & Aim: Protein-Energy malnutrition is one of the most important world's health problems, especially among the children under the age of 5. Thus, this study was conducted with regard to the known complications and different reports of the prevalence and the determinants of this disorder. The goal of the present study was to determine the prevalence and determinants of protein-energy malnutrition among children under the age of 5. Patients & Methods: A descriptive cross-sectional study was conducted between Oct.2002 to Feb. 2003 in Savojbolagh. Sampling was based on 20% prevalence of malnutrition, 95% CI, design effect of 1.8, and d=0.03. By employing random cluster sampling technique, 1243 samples were chosen (632 rural samples and 603 urban samples). Data was collected by means of questionnaire, interview and observation. Results: The most important findings in this study were as follows. The prevalence of stunting among the girls was more than the boys (12.1%, 8.7% respectively). Prevalence of wasting was 4.7% in girls and 3.7% in boys. Age(P<0.043), weight(P<0.001) and height (P<0.001) of the children had significant correlation with malnutrition. There was a significant correlation between malnutrition and calorie of diet(P<0.038) in 3-4 age group. This study also showed a significant correlation between low weight for height for age and low protein in children's diet (P<0.01)(1-2 and 2-3 age groups). Conclusion: According to the findings of this study, children were suffering from the mild malnutrition. The determinants affecting the children in this study were: mother's lack of knowledge of appropriate time for beginning complementary food(P<0.022), use of no complementary food (P<0.045), and spending half of the household income on food (P<0.039).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":74168983,"openaccessinfo":{"externalids":{"MAG":"2285714917","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recent progress in few-shot learning promotes a more realistic cross-domain setting, where the source and target datasets are in different domains. Due to the domain gap and disjoint label spaces between source and target datasets, their shared knowledge is extremely limited. This encourages us to explore more information in the target domain rather than to overly elaborate training strategies on the source domain as in many existing methods. Hence, we start from a generic representation pre-trained by a cross-entropy loss and a conventional distance-based classifier, along with an image retrieval view, to employ a re-ranking process to calibrate a target distance matrix by discovering the k-reciprocal neighbours within the task. Assuming the pre-trained representation is biased towards the source, we construct a non-linear subspace to minimise task-irrelevant features therewithin while keep more transferrable discriminative information by a hyperbolic tangent transformation. The calibrated distance in this target-aware non-linear sub-space is complementary to that in the pre-trained representation. To impose such distance calibration information onto the pre-trained representation, a Kullback-Leibler divergence loss is employed to gradually guide the model towards the calibrated distance-based distribution. Extensive evaluations on eight target domains show that this target ranking calibration process can improve conventional distance-based classifiers in few-shot learning.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":244773016,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/CVPR52688.2022.00889","PubMedCentral":null,"ArXiv":"2112.00260"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As the effort to scale up existing quantum hardware proceeds, it becomes necessary to schedule quantum gates in a way that minimizes the number of operations. There are three constraints that have to be satisfied: the order or dependency of the quantum gates in the specific algorithm, the fact that any qubit may be involved in at most one gate at a time, and the restriction that two-qubit gates are implementable only between connected qubits. The last aspect implies that the compilation depends not only on the algorithm, but also on hardware properties like connectivity. Here we suggest a two-step approach in which logical gates are initially scheduled neglecting connectivity considerations, while routing operations are added at a later step in a way that minimizes their overhead. We rephrase the subtasks of gate scheduling in terms of graph problems like edge-coloring and maximum subgraph isomorphism. While this approach is general, we specialize to a one-dimensional array of qubits to propose a routing scheme that is minimal in the number of exchange operations. As a practical application, we schedule the quantum approximate optimization algorithm in a linear geometry and quantify the reduction in the number of gates and circuit depth that results from increasing the efficacy of the scheduling strategies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":44304151,"openaccessinfo":{"externalids":{"MAG":"2953155615","ACL":null,"DOI":"10.1088\/2058-9565\/aacf0b","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1708.00023","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Introduction\/Background Diagnosed cancer during pregnancy is a very rare situation related to severe maternal and neonatal morbidity and mortality. Diagnosis, proper management and monitoring of these cases requires specialized knowledge, experience and cooperation of many specialties. The aim of this study is to determine the maternal and neonatal morbidity and mortality in these cases and the impacts caused by a delayed diagnosis or treatment of a malignancy during pregnancy. Methodology We retrospectively reviewed the medical records of patients, who were diagnosed with malignancy during pregnancy and gave birth to viable fetuses (>25th week of gestation) from May 2004 to February 2019, in our clinic. Cases with in situ carcinoma were excluded. Results Out of 25.672 pregnant women 16 (0.06%) were diagnosed with gynecological malignancy during pregnancy. The average age of patients was 35 years old. 14.2% of the cases were diagnosed in 1st trimester, 64.3% in 2nd and 21.5% in 3rd trimester pregnancy. Maternal mortality rate raised to 35.7%. The disease was initially diagnosed in 24.1% of the patients and the recurrence rate of known malignancies in pregnancy was 14.2%. 21,4% of these women were diagnosed with advanced stage cancer. In 57% of the cases there was a delayed diagnosis, mainly caused by underestimation of the symptoms by the doctor. 78.6% were led to premature birth by caesarean section in order to complete the treatment of the malignancy. The mean age of gestation was 31w+3d and the average birth weight of newborns was 1600 kg. Conclusion In 57% of the cases of cancer during pregnancy there was a delayed diagnosis due to underestimation of the symptoms by the doctor. Only 21.4% of the women were treated for the malignancy continuing their pregnancy in order to prevent premature birth and bad neonatal outcome. Disclosure Nothing to disclose.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":209282500,"openaccessinfo":{"externalids":{"MAG":"2983158261","ACL":null,"DOI":"10.1136\/ijgc-2019-esgo.741","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Aim of the Study The aim of the study is to examine the detection rates of malformations before and after the introduction of extended basic screening in Hesse by the Federal Joint Committee (Gemeinsamer Bundesausschuss, GQH) on July 1, 2013. Method This is a retrospective, mainly exploratory data analysis of quality assurance data from the Office for Quality Assurance in Hesse (GQH). The data was collected in the period from January 1, 2010 to December 31, 2016 in the obstetric departments of the Hessian hospitals using documentation forms. The classification and evaluation of the diagnoses is based on ICD-10-GM-2019. Results At least one malformation is present in 0.7% of the cases. With a share of 30.0%, most of the congenital malformations are from the musculoskeletal system. 12.2% of the malformations come from the facial cleft, closely followed by malformations of the circulatory system with 11.3%. The highest prenatal detection rate (PDR) is found in congenital malformations of the nervous system at 56.8%. The lowest PDR is found in those of the genital organs with 2.1%. The PDR of cardiovascular malformations is 32.9%. Overall, a PDR of 25.2% is achieved. There was no change in the number of prenatal malformation diagnoses after the introduction of extended basic ultrasound. The distribution of malformation diagnoses not detected prenatally to the organ systems also has not changed after the introduction. Conclusion The introduction of extended basic ultrasound did not bring the desired improvement with regard to the PDR in Hesse. Alternative approaches should be considered.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247547616,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1055\/a-1778-3585","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The microstructure of gas shale samples from nine different formations has been investigated using a combination of focused ion beam (FIB) milling and scanning electron microscopy (SEM). Backscattered electron (BSE) images of FIB cross sectioned shale surfaces show a complex microstructure with variations observed among the formations. Energy dispersive spectroscopy of the shale cross sections indicates that clay, carbonate, quartz, pyrite, and kerogen are the most prevalent components. In the BSE images, areas of kerogen are observed interspersed with the inorganic grains. Pores are observed in both the kerogen and inorganic matrix with the size, shape, and number of pores varying among the shale samples. By using FIB milling and SEM imaging sequentially and repetitively, three-dimensional (3-D) data sets of SEM images have been generated for each of the shale samples. Three-dimensional volumes of the shales are reconstructed from these images. By setting thresholds on the gray scale, the kerogen and pore networks are segmented out and visualized in the reconstructed shale volumes. Estimates of kerogen and pore volume percentages of the reconstructed shale volumes have been made and range from 0 to 90.0% for the kerogen and 0.2 to 2.3% for pores. Estimates of pore-size distributions suggest that although pores with radii of approximately 3 nm dominate in number, they do not necessarily dominate in total volumetric contribution. Scanning electron microscopy images and 3-D reconstructions reinforce the facts that shales are quite different and that their microstructures are highly variable and complex.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":129978208,"openaccessinfo":{"externalids":{"MAG":"2140460370","ACL":null,"DOI":"10.1306\/08151110188","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Chronic Arsenic Toxicity may have varied clinical presentations ranging from non-cancerous manifestations to malignancy of skin and different internal organs. Dermal lesions such as hyper pigmentation and hyperkeratosis, predominantly over palms and soles are diagnostic of Chronic Arsenicosis. We report two cases from a family living in Sukkur who presented with classical skin lesions described in Chronic Arsenicosis. The urine, nail and hair samples of these patients contained markedly elevated levels of arsenic. Also the water samples from their household and the neighbouring households were found to have alarming levels of inorganic Arsenic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21649270,"openaccessinfo":{"externalids":{"MAG":"23484414","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Complexes between sodium (sulfamate-carboxylate)isoprene\/ethylene oxide double hydrophilic diblock copolymers (SCIEO) and dodecyltrimethylammonium bromide (DTMAB), as well as quaternized poly(2-vinylpyridine) (QP2VP), were studied in aqueous solutions, at pH 7. The complexes are formed due to electrostatic interactions between the anionic groups of the polyelectrolyte block of the copolymers and the cationic groups of the surfactant or the homopolyelectrolyte. The structure of the complexes was investigated as a function of the mixing ratio of the two components in solution and ionic strength by static, dynamic, and electrophoretic light scattering, atomic force microscopy, and fluorescence spectroscopy. The mass and size of the complexes depend on the mixing ratio between the components. A transition from intrachain to an interchain association was observed for block copolymer\/ surfactant complexes. SCIEO\/QP2VP complexes were found to respond to increasing concentrations of added salt. Spherical and ellipsoid shaped complexes with a core-shell micellar like structure were formed in the systems studied.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25311532,"openaccessinfo":{"externalids":{"MAG":"2032736580","ACL":null,"DOI":"10.1021\/JP067437Z","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The sulfur vulcanization of NR by a MBT-TMTD mixed accelerator system both in the presence and absence of ZnO and stearic acid with or without DCP has been studied. The rate of decomposition of DCP in the presence of both MBT and TMTD is quite similar to that in the MBT system alone. The reduction in crosslinking due to DCP is dependent mainly on MBT. The decomposition product of TMTD may contribute to it only at the later stage of vulcanization. Though TMTD has no influence on the decomposition rate, it reacts with MBT at least in the initial stage of vulcanization and suppresses the retardation caused by MBT on DCP vulcanization in accordance with the free sulfur decrease, the nature of crosslinking formation both in the presence and absence of DCP, and the methyl iodide treatment of the vulcanizates. The vulcanization process of the MBT-TMTD-S-NR system has been interpreted in terms of both free radical and polar mechanisms. The domination of either of these depends on the dominant amount of either MBT or TMTD in the acclerator ratio. According to the initial high rate of crosslink formation, free sulfur decrease and also the initial additiveness of crosslinking in stocks containing DCP, the vulcanization process of MBT-TMTD-ZnO-St. acid-S-NR system has been explained in terms of an ionic mechanism. The pronounced synergistic nature of such systems has been interpreted by the enhanced activation of MBT-S-ZnO-St. acid complex due to the dithiodicarbamate ion formed in the initial stages of vulcanization, and also by the activation of TMTD accelerated vulcanization due to the mercaptobenzothiazylion.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97627482,"openaccessinfo":{"externalids":{"MAG":"2152501921","ACL":null,"DOI":"10.1002\/APP.1979.070230117","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Family business, as the most popular business form, dominates the world economy (Astrachan and Shanker, 2003). Compared with other business forms, family business presents important particularities that stem from a family business system perspective that integrates the family, ownership, and business subsystems (Tagiuri and Davis, 1982). Due to its role and uniqueness, an important growth of family business research has been recorded over the past three decades. While the main research directions were focused on family firms' behavior and the results of such behavior (Massis and Foss, 2018) fewer cultural studies were conducted in family business. The research purpose is to analyze the current state of theory in family business research and discuss its cultural implications from the perspective of a literature review focused on the cultural dimensions of family firm investigation. The study proposes possible directions for future research toward a better understanding of family firm as a cultural phenomenon.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":235114713,"openaccessinfo":{"externalids":{"MAG":"3137206064","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Most current games are composed of simple operations without a user's actual movements. because they are made up of only virtual space. For that reason, many side effects arise on a user's body and mind. The Alternative Reality Game(ARG) is new game genre that has an effect to mitigate side effects caused by activity on a virtual space. This new kind of game genre can be instrumental role in creating a greater social intimacy and a higher tendency to cooperate that potentially reaches beyond the game context. In this paper, we suggest a real implementation of ARG using mobile devices and NFC tags. In addition, a noble editor for creating an ARG and a game launcher based on mobile device are suggested.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":196154994,"openaccessinfo":{"externalids":{"MAG":"2883337278","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We discuss the maxima in stress which were recently observed in the start up of shearing flows of entangled polymer melts with a complex branched structure. More than one maximum has been observed, and maxima can be found at extremely large values of deformation, of the order of several hundred units of shear. Furthermore, such maxima may disappear upon repeating the experiment, to come up again only after an extremely long resting time. By assuming that such high-deformation maxima are due to stretching of the internal segments of the branched structure, we develop a model able to estimate the unusual location of the maxima. The physical model underlying the calculations is also consistent with the observed effect of the resting time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250446441,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus. This serious disease continues to be an important public health problem as it is endemic in many parts of the world. Cystic disease affects many organs in the body, most commonly the liver. Hydatid disease can cause a diverse spectrum of symptoms, from asymptomatic infection to potential death. In the presence of clinical suspicion, the diagnosis is made by serology and imaging methods. Imaging findings can range from completely cystic lesions to completely solid appearance and calcification. The imaging method to be used depends on the involved organ and the stage of the cyst. The updated recommendations of the World Health Organization-Echinococcosis Informal Working Group for the stage and treatment of human echinococcosis have had important implications. Accordingly, there are 4 approaches to the clinical management of hydatid disease: surgery, percutaneous techniques and drug therapy for active cysts, and a \"watch and wait\" approach for inactive cysts. Since it directly affects the treatment, it is necessary to be familiar with the imaging findings of the cyst, especially in endemic areas.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":255972490,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5152\/eurasianjmed.2022.22309","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.5152\/eurasianjmed.2022.22309","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Logical probability theory was developed as a quantitative measure based on Boole's logic of subsets. But information theory was developed into a mature theory by Claude Shannon with no such connection to logic. But a recent development in logic changes this situation. In category theory, the notion of a subset is dual to the notion of a quotient set or partition, and recently the logic of partitions has been developed in a parallel relationship to the Boolean logic of subsets (subset logic is usually mis-specified as the special case of propositional logic). What then is the quantitative measure based on partition logic in the same sense that logical probability theory is based on subset logic? It is a measure of information that is named \"logical entropy\" in view of that logical basis. This paper develops the notion of logical entropy and the basic notions of the resulting logical information theory. Then an extensive comparison is made with the corresponding notions based on Shannon entropy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15751907,"openaccessinfo":{"externalids":{"MAG":"2520780871","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this very article the concepts of alternative and alternative history are researched within modern literary process on material of novels \u00abLavr\u00bb and \u00abAviator\u00bb by Evgeny Vodolazkin and \u00abZuleikha Opens Her Eyes\u00bb by Guzel Yakhina. To make this analysis wider and more versatile some works by other famous authors are involved. Among them, there are such novels as \u00abRakhil\u00bb by Andrey Gelasimov, \u00abSinologist\u00bb by Elena Chizhova and \u00abQuest\u00bb by Boris Akunin. As a matter of fact, alternative history as a science fiction genre means the development of historical happenings influenced by a number of circumstances. We consider alternative history in broad context, which means as the phenomenon of choice, variant, variation that are closely connected with the semantic of the word \u00abalternative\u00bb. The article provides readers with some researches of such literary alternative models as alternative \u00f1hronotope, alternative character, alternative history method. Alternative chronotope involves augmented reality, the world created by the demiurge-character inside the common space-time work construction. Creating of such world is closely connected with trauma and with character's try to protect himself from the outside influence. The doubles are called in this research alternative characters since their paired existence, where each of them has its other variant. On material of novel \u00abAviator\u00bb, the types of doubles are shown. Thus the system of characters is created. Contexture is built in a mirror-principal. With the help of such technique, the author creates the infinity and out-of-time effects. The term \u00abalternative history method\u00bb in this article means synthesis of fantastical and documental in the novels by Evgeny Vodolazkin. This combination defines genre uniqueness of authors' books. In this research work we also discuss the problem of genre mashup in Russian literature and integrated approach to the analysis of alternative-historical fantastic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":239339845,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18287\/2542-0445-2018-24-4-139-143","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.18287\/2542-0445-2018-24-4-139-143","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background Previous studies suggest that thyroid hormone supplementation alters fetal gene expression while improving left ventricular systolic function and exercise capacity in heart failure. Our objective was to test the hypothesis that administration of thyroid hormone to patients with idiopathic dilated cardiomyopathy (IDC) would reverse myocardial fetal gene expression, improve cardiac hemodynamics, and improve exercise capacity. Methods 6 adults from University of Colorado Hospital with IDC with ejection fractions less than 35% received thyroid hormone (1.33 mcg\/kg\/day, mean dose 129 \u00b116 mcg\/day) for 3 months. All subjects were on standard medical therapy for heart failure. We measured myocardial fetal gene expression using reverse transcriptase PCR at baseline and after thyroid hormone therapy. We also measured exercise capacity and right heart catheterization hemodynamics at baseline and after thyroid hormone therapy. Data were analyzed using a paired t-test of the means. Results Mean TSH levels decreased from 2.24 \u00b1 1.39 mU\/L to 0.072 \u00b1 0.066 mU\/L (p=0.34). There was no significant change in fetal gene expression of alpha myosin heavy chain, beta myosin heavy chain, atrial naturetic peptide, or SRCa++ ATPase from baseline to post-thyroid therapy. There was no significant change in right heart catheterization measurements of cardiac output (5.12 \u00b1 1.89 L\/min pre, 5.18 \u00b1 0.84 L\/min post, p=0.94), pulmonary capillary wedge pressure (12.2 \u00b1 9.1 mmHg pre, 13.7 \u00b1 6.2 mmHg post, p=0.42), systemic vascular resistance (1579 \u00b1 418 dynes.sec\/cm^5 pre, 1431 \u00b1 260 dynes.sec\/cm^5 post, p=0.59). There was also no significant change in exercise capacity measured by the 6 minute walk test (1486 \u00b1 327 feet pre, 1430 \u00b1 284 feet post, p =0.62), ventilatory efficiency slope (32.8 \u00b1 6.38 pre, 33.3 \u00b1 5.76 post, p=0.32), VO2 at anerobic threshold (15.3 \u00b1 3.6 pre, 14.1 \u00b1 5.61 post, p=0.45), or peak VO2 (19.0 \u00b1 4.9 ml\/kg\/min pre, 19.6 \u00b1 4.1 ml\/kg\/min post, p=0.43). Conclusion Short-term thyroid hormone at a dose of 1.33 mcg\/kg\/day does not reverse fetal gene expression or significantly improve hemodynamics or exercise capacity in patients with idiopathic dilated cardiomyopathy receiving standard heart failure therapy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":76058817,"openaccessinfo":{"externalids":{"MAG":"2373730622","ACL":null,"DOI":"10.2310\/6650.2005.00005.249","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Diamond and Silicon Carbide (SiC) are promising wide band-gap semiconductors for power electronics, SiC being more mature especially in term of large wafer size (200 mm). Nitrogen impurities are often used in both materials for different purpose: increase the diamond growth rate or induce n-type conductivity in SiC. The determination of the nitrogen content by secondary ion mass spectrometry (SIMS) is a difficult task mainly because nitrogen is an atmospheric element for which direct monitoring of N\u00b1 ions give no or a weak signal. With our standard diamond SIMS conditions, we investigate 12C14N- secondary ions under cesium primary ions by applying high mass resolution settings. Nitrogen depth-profiling of diamond and SiC (multi-) layers is then possible over several micrometer thick over reasonable time analysis duration. In a simple way and without notably modifying our usual analysis process, we found a nitrogen detection limit of 2x1017 at\/cm3 in diamond and 5x1015 at\/cm3 in SiC.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":244709657,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4028\/p-684nsi","PubMedCentral":null,"ArXiv":"2111.13376"},"license":"CCBY","url":"https:\/\/www.scientific.net\/MSF.1062.376.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The ancient parallel between literature and the visual arts - i.e. painting, sculpture, and architecture - becomes newly relevant in the twentieth century. Painters were the first to explore the revolutionary possibilities of Modernism, so that painting became the leading art form. Modernist writers often patterned their literary experiments on parallels drawn from the visual arts. It is impossible to understand fully the development of literary Modernism, therefore, without at least a rudimentary knowledge of modern art. This chapter is intended to provide a brief history of modern art for those whose primary interest is modern British and American literature. It follows the version of Modernism that was endorsed by the Museum of Modern Art in the 1930s and that has served as the standard for most of this century. Literary parallels will be drawn primarily from poetry, since there the influence of the visual arts is deepest and most direct.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":193384828,"openaccessinfo":{"externalids":{"MAG":"2505305732","ACL":null,"DOI":"10.1017\/CCOL0521495164.009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors determined mean day-to-day (daily over five days), mean week-to-week (weekly over five weeks) and mean hour-to-hour (800 h, 1100 h, 1400 h) physiologic intra-individual variation of concentration values of leukocyte cell types, platelet count, and erythrocyte values (hematocrit, hemoglobin) for a group of 20 healthy adult volunteers. Total leukocyte counts and concentration values of leukocyte cell types were determined in duplicate on the Hemalong-DTM Automated Leukocyte Differential Cell Counter to minimize analytic variation. The data sets were analyzed according to an analysis of variance model. The mean physiologic hour-to-hour and week-to-week intra-individual variations in terms of % coefficient of variation included: hemoglobin, 2.5, 2.2; hematocrit, 2.6, 2.7; platelets, 1.6, 6.6; total leukocyte count, 9.4, 15.7; neutrophils, 12.9, 26.0; lymphocytes, 10.3, 13.2; monocytes, 18.6, 19.3; eosinophils, 19.9, 26.9; basophils, 7.4, 15.0; large unstained cells, 13.7, 16.0; \"high-peroxidase\" cells, 32.7, 25.7. Hour-to-hour variation was partitioned into random diurnal variation, group-consistent diurnal variation, and subject-specific unique individual variation. Subject-specific diurnal variation contributed greatly and statistically significantly to total diurnal variation for many of the leukocyte cell types--especially in the case of eosinophils, where it represented more than half of total diurnal variation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8661355,"openaccessinfo":{"externalids":{"MAG":"62693281","ACL":null,"DOI":"10.1093\/AJCP\/69.1.48","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to analyze the development of white blood cells in blood of neonatal piglets immediately after birth and colostrum intake. Together 8 newborn piglets (Large white) were included in this study. Piglets were during whole experiment under his mother and the colostrum intake was ad libitum. Blood samples (1.0 mL) were collected before colostrum intake (0 hour) and on 3 rd , 6 th and 12 th hour after first colostrum intake. Heparinized blood samples were used for total white blood cells, lymphocytes, mid-sized cells and granulocytes determinations. Blood samples were analyzed using haematological analyser Abacus Junior Vet (Diatron, Austria). The results were statistically analyzed by a one-way ANOVA, the differences in average means of blood cells between different sampling times were tested with T-test. The content of white blood cells (P<0.01), lymphocytes (P<0.001), mid-sized cells (P<0.05) as well as granulocytes (P<0.05) changed statistically during the first 12 hours of piglets life. Only in the samples collected on 6 th and 12 th hour of piglets life, the white blood cells (11.68 resp. 10.82 G*l -1 ) and lymphocytes (8.13 resp. 9.63 G*l -1 ) reached the lower physiological range for pigs. Other white blood cells indices of neonatal piglets did not reach the lower limit of the reference range. However in all white blood cells indices, we detected very high differences between minimal and maximal values. It points out, that some newborn piglets had very low, whereas some newborn piglets had very high content of white blood indices and it suggest, that some piglets of the litter had better protection, whereas another piglets not.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":32468567,"openaccessinfo":{"externalids":{"MAG":"2421819453","ACL":null,"DOI":"10.5513\/JCEA01\/16.4.1644","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we use a SVAR model in order to study the asymmetry of growth and inflation developments in the acceding countries vis-a-vis the euro area over the years 1995-2003. The model combines two strands of the literature, the explanation in terms of country-specific and euro area shocks, and a further split between supply and demand shocks. The four structural shocks may all create asymmetries vis-a-vis the euro area. It appears that country-specific shocks are the main source of growth or inflation divergence, rather than the distinct way in which acceding countries react to euro area shocks. But whereas country-specific supply shocks are mainly responsible for growth divergence, country-specific demand shocks are mainly responsible for inflation asymmetry. Hence, a low asymmetry in terms of growth does not necessarily imply a low asymmetry in terms of inflation, although the latter is particularly important for countries aiming to join the euro area. There is some evidence that both asymmetries were on the fall over the last years of the sample.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":152702983,"openaccessinfo":{"externalids":{"MAG":"326247549","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Six strains of Salmonella typhimurium (TML, W118, LT7, SL1027, M206 and Thax-1) of known virulence and ability to induce fluid secretion when inoculated into the rabbit ileum were examined for enterotoxin production. Enterotoxic activity, assayed in the rabbit ileal-loop test, was detected in polymyxin-B extracts from all strains (with the possible exception of Thax-1) cultured for 6 h in casamino acid-yeast extract medium. The extracts were inactive in tissue-culture assays with CHO, Y-1 adrenal and Vero cells, and in the infant mouse assay for enterotoxin. There was no correlation between enterotoxigenicity in vitro and the ability of whole organisms to induce fluid secretion in vivo. The significance of these results in relation to salmonellosis is discussed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":32776196,"openaccessinfo":{"externalids":{"MAG":"2086694010","ACL":null,"DOI":"10.1099\/00222615-21-1-19","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1099\/00222615-21-1-19","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background: The 3-year family practice residency curriculum includes longitudinal care of children in the family health center and a 4-month experience dedicated to the care of children. This study was designed to compare the diseases of hospitalized children cared for by family physicians and pediatricians and to examine the use of pediatricians as consultants by family physicians. Methods: The study included all patients younger than 18 years who were discharged by a family physician or a pediatrician from this semirural hospital during a 3-year period. The primary discharge diagnosis, physician, consultations, and transfer status were recorded. Results: Family physicians cared for 37 percent of the 4169 pediatric patients discharged during the study. Infectious diseases and their complications were the most common conditions for patients who were discharged beyond the newborn period. The 15 most frequent discharge diagnoses were identical for family physicians and pediatricians, accounting for about 86 percent of all discharge diagnoses. Pediatricians, however, cared for 86 percent of the newborns with major complications and were responsible for 80 percent of the infants and children who were transferred. The overall inpatient consultation rate of pediatricians by family physicians was 8 percent, whereas the consultation rate for nonneonatal-related discharges was 20 percent. Conclusion: In this semirural environment, family physicians and pediatricians care for a very similar mix of hospitalized pediatric patients. Pediatricians, however, care for a greater proportion of newborns with major complications.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":44340686,"openaccessinfo":{"externalids":{"MAG":"2027803949","ACL":null,"DOI":"10.3122\/jabfm.12.2.128","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jabfm.org\/content\/12\/2\/128.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Is coping with illness really a matter of agency? Drawing on ethnographic research among people with rheumatological and neurological chronic diseases in the United States, I argue that patients' coping strategies were informed by a cultural expectation of productivity that I call the \"John Wayne Model,\" indexing disease as something to be worked through and controlled. People able to adopt a John Wayne\u2013like approach experienced social approval. Yet some people found this cultural model impossible to utilize and experienced their lack of agency in the face of illness as increasing their suffering, which was made all the worse if their sickness was invisible to others. Unable to follow the culturally legitimated John Wayne model, people fell into what I call the \"Cultured Response\"\u2014the realm beyond the agency embedded in cultural models, in which people do not resist but embrace as ideal the cultural expectations they cannot meet and that oppress their sense of value in the world. [suffering, cultural models, agency, chronic illness, United States, cultural anthropology, medical anthropology]","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144615500,"openaccessinfo":{"externalids":{"MAG":"2068690250","ACL":null,"DOI":"10.1111\/J.1548-1425.2010.01254.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT: Neutrophil leukocyte morphology was examined in whole blood films from 20 patients with palmoplantar pustulosis (PPP) and 32 healthy controls. In the PPP patients, there was a significant increase in the number of neutrophils having polarized morphology or membrane ruffling; however, there was no significant difference in neutrophil morphology between cigarette smokers and nonsmokers, suggesting that the epidemiologic link between smoking and PPP is not explained by increased polarization of peripheral blood neutrophils.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41539063,"openaccessinfo":{"externalids":{"MAG":"2045767950","ACL":null,"DOI":"10.1111\/j.1365-4362.1987.tb00588.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper proposes a new technique for robust state estimation in the presence of a small number of topological errors for power systems modeled by AC power flow equations. The developed method leverages the availability of a large volume of SCADA measurements and minimizes the $\\ell_{1}$ norm of nonconvex residuals augmented by a nonlinear, but convex, regularizer. Noting that a power network can be represented by a graph, we first study the properties of the solution obtained by the proposed estimator and argue that, under mild conditions, this solution identifies (small) subgraphs of the network that contain the topological errors in the model used for the state estimation problem. Then, we propose a method that can efficiently detect the topological errors by searching over the identified subgraphs. Furthermore, we develop a theoretical upper bound on the state estimation error to guarantee the accuracy of the proposed state estimation technique. The efficacy of the developed framework is demonstrated through numerical simulations on an IEEE benchmark system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201812657,"openaccessinfo":{"externalids":{"MAG":"2972876845","ACL":null,"DOI":"10.23919\/ACC.2019.8814813","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The F1 progeny of Culex tarsalis Coquillett females from the Coachella (CV) and San Joaquin (SJV) valleys collected during April 1991, and April, July, and October 1993 were reared and maintained as adults at 5 constant temperatures ranging from 14 to 38 degrees C. CV F1 progeny exhibited smaller body size, enhanced survival during spring, and higher autogeny rates than SJV F1 progeny; however, upper and lower thermal tolerance limits, immature developmental rates and survivorship, and adult life table parameters were relatively similar for both strains. Mosquitoes from both sites exhibited midsummer changes in immature developmental rates and survivorship, adult wing length, life expectancy at emergence, and generation time. These data indicated that temperature may select for both spatial and temporal changes in mosquito biology.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20655114,"openaccessinfo":{"externalids":{"MAG":"2333098439","ACL":null,"DOI":"10.1093\/JMEDENT\/32.5.636","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We explore the properties of a feed-forward neural network whose couplings are chosen in such a way as to maximize the input-output mutual information, in the case in which the input-output channel is aaected by noise.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16764981,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nMesenchymal stem cells (MSCs) from bone marrow are capable of differentiating into cells of different tissue lineages such as bone, cartilage, and adipose tissue and are the best candidates for tissue engineering. It is well accepted that umbilical cord blood (UCB) is a source for hematopoietic stem cells. However, controversy exists as to whether UCB contains MSCs and can serve as a source of MSCs. Therefore, the aim of this study was to explore the biological characteristics and inducing differentiation ability of in vitro expanded UCB MSCs.\n\n\nMETHODS\nUCB was collected on normal full term delivery of infants with informed consent (n = 35) obtained from the mothers. Mononuclear cells (MNCs) were isolated from UCB by gravity centrifugation and cultured with DMEM including 10% fetal bovine serum. The morphology was observed under microscope per day. Cytochemical staining was carried out and flow cytometry was used to examine the surface antigen phenotype. Fifth passage cells were transferred into a different medium and osteogenic differentiation, adipogenic differentiation, and neurogenic differentiation were assessed.\n\n\nRESULTS\nMSCs could be isolated and cultured from MNCs of a few UCB sources. These cells displayed fibroblast-like morphology. They withstood over 20 passages without significant structural changes. These MSCs were negative for alkaline phosphatase (ALP) staining and positive for alpha-naphthol butyric acid esterase (NBE) staining. Expression of CD(29), CD(44)and CD(105), especially the human MSCs-specific markers SH-2 and SH-3 were observed, but CD(3), CD(14), CD(19), CD(34) and CD(45) could not be found, indicating that these cells were not of hematopoietic origin. Exposure of these MSCs to serum-free osteogenic condition, they could differentiate into bone cells and form mineralized matrix as evidenced by Alizarin red staining 2 weeks later. When these UCB-derived MSCs were cultured in adipogenic medium, morphologic changes in cells as well as the formation of neutral lipid vacuoles were noticeable as early as 1 week after induction and visualized by staining with oil-red O. Surprisingly, these MSCs were also able to differentiate into neuroglial-like cells. Morphology of these induced cells resembled that of neurons. Immunocytochemistry showed that they expressed Nestin and neuron-specific enolase (NSE), but not glial fibrillary acidic protein (GFAP).\n\n\nCONCLUSION\nUCB does contain MSCs. These MSCs, which are multipotent, could be isolated and cultured from a few UCB sources. UCB might serve as an alternative source of MSCs to bone marrow.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":37940343,"openaccessinfo":{"externalids":{"MAG":"2361830582","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes the work of the Honduran organization Mujeres en las Artes (MUA) - Women in the Arts - over the past 20 years. Starting from life stories and artistic creations - such as representation, interpretation and explanation of the everyday world - the body is considered as territory, as a metaphor that mediates personal and collective processes. Therefore, the artistic language endures memories and provides meaning to life. As a consequence, - violence, trauma, marks, oblivion and silence confront the paradigmatic discourses that support culture and science; declaiming for knowledge and learning of what the body is able to explore, as warned by Merleau Ponty.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197706070,"openaccessinfo":{"externalids":{"MAG":"2953242324","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Accurately estimating surface melt volume of the Antarctic Ice Sheet is challenging, and has hitherto relied on climate modelling, or on observations from satellite remote sensing. Each of these methods has its limitations, especially in regions with high surface melt. This study aims to demonstrate the potential of improving surface melt simulations ::: with :: a ::::::: regional :::::: climate :::::: model by deploying a deep learning model. A deep-learning-based framework has been developed to correct surface melt from the regional atmospheric climate model version 2.3p2 (RACMO2), using meteorological observations 5 from automatic weather stations (AWSs), and surface albedo from satellite imagery. The framework includes three steps: (1) training a deep multilayer perceptron (MLP) model using AWS observations; (2) correcting moderate resolution imaging spectroradiometer (MODIS) albedo observations, and (3) using these two to correct the RACMO2 surface melt simulations. Using observations from three AWSs at the Larsen B and C Ice Shelves, Antarctica, cross-validation shows a high accuracy (root mean square error = 0.95 mm w.e.per day, mean absolute error = 0.42 mm w.e.per day, and coefficient of determination 10 = 0.95). Moreover, the deep MLP model outperforms conventional machine learning models (e.g., random forest regression, XGBoost) and a shallow MLP model. When applying the trained deep MLP model over the entire Larsen Ice Shelf, the resulting , corrected RACMO2 surface melt shows a better correlation with the AWS observations for two out of three AWSs. However, for one location (AWS 18) the deep MLP model does not show improved agreement with AWS observations, likely due to the heterogeneous drivers of melt :::::: because :::::: surface :::: melt :: is :::::: driven :: to : a ::::: large ::::: extent :: by ::::: other :::::: factors ::::: (e.g., :: air ::::::::::: temperature, 15 ::::::::: topography, :::::::: katabatic :::::: wind) :::: than :::::: albedo ::::: alone : within the corresponding coarse resolution model pixels. Our study demonstrates the opportunity to improve surface melt simulations using deep learning combined with satellite albedo observations. On the other hand, more work is required to refine the method, especially for complicated and heterogeneous terrains.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":245985191,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectively measured population physical activity (PA) data is lacking in Malaysia. Objective measurement is currently viewed as the minimum standard for PA assessment in epidemiological research because it decreases the element of bias commonly found through self-report methods. The aim of this study was to determine the feasibility of measuring physical activity (PA) level and sedentary behaviour of Malay adults using an ActiGraph GT3X accelerometer. All twenty participants (mean age 58.6 \u00b1 18.1 years) in the study were compliant in wearing the accelerometer for at least 12 hours per day for 7 consecutive days, and the desired PA parameters were properly measured. All subjects were sedentary for 59 % of the wear time. Participants spent on average 24 minutes daily at a moderate intensity of PA and at least one bout of sustained 10 minutes of PA per week. Mean activity counts per minute were in the 'light intensity' category (vector magnitude 486.7 \u00b1 170.3) and step counts per day were in the 'active' category (12,462.0 \u00b1 3,813.0 steps). Overall, the results demonstrate that participants are generally inactive and the high compliancy means that the use of accelerometers is feasible for studying the PA level of the Malay adult population.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":155373307,"openaccessinfo":{"externalids":{"MAG":"2942629899","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reports a versatile method to fabricate robust carbon\/metal hybrids with ultrasmall particle and highly developed porous structure through a scalable and facile way. Alginate is used as the precursor for it could perform cross-linking reaction with different polyvalent metal ions to form gels. After simple freeze-drying and carbonization of the alginate-derived gels, we obtained the carbon\/metal hybrids with fine nanostructure. Eleven kinds of metal ions were introduced to form gels and five kinds of the gels were carbonized to produce the carbon\/metal hybrids. By adjusting the reaction condition, we could tune the size of the nanoparticles in the obtained hybrids. The obtained SnO2\/C hybrid shows outstanding specific capacity, rate performance, and long cycle life when it is used as the anode materials of lithium ion batteries. The ultrasmall active nanoparticles were uniformly dispersed within an interconnected pore framework. It ensured a short diffusion and transportation distance of electrolyte ions to the surfaces of active nanoparticles. In addition, the robust carbon framework comprises of quasigraphitic carbon layers. It contributed to the high rate performance by providing excellent conductive pathways for electrons within the electrodes. This work provides a general method for fabrication of carbon\/metal (oxide) hybrids with fine nanostructure for application in energy storage.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26572891,"openaccessinfo":{"externalids":{"MAG":"2191750422","ACL":null,"DOI":"10.1021\/acsnano.5b06022","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Sometimes, child's rheumatic diseases are generating emergency type complications which, if not diagnosed in time, are life-threatening. Antiphospholipid syndrome in its severe form can induce coagulation disorders and acute organ failure, depending on location and extent. Systemic lupus erythematosus is frequently associated with this pathology and must be carefully investigated and monitored in the evolution of the patient, in order to benefit from early specific anticoagulant treatment, associated with chronic background immunosuppressive treatment.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1,"unknown":2}},"corpusid":261391510,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.26416\/pedi.70.2.2023.8307","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.26416\/pedi.70.2.2023.8307","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"THE HIGHLY COMPLEX NATURE of the material, the resulting difficulty in establishing significant tests for evaluation in a reasonable time, and the varying conditions of use have combined to make the study of oils used for the insulation and cooling of transformers a painfully slow process. It is the purpose of this article to review some of the very extensive efforts made in this study and to draw at least tentative conclusions as to the present status and future possibilities of one of the most important materials in the design, manufacture, and operation of transformers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":51649453,"openaccessinfo":{"externalids":{"MAG":"2295888680","ACL":null,"DOI":"10.1109\/ee.1951.6437203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"G. Szego showed that the sum of the three translational virtual masses along any three mutually perpendicular directions is an invariant for a solid moving in an infinite, incompressible, frictionless and irrotational fluid medium. A similar hypothesis is presented here, which shows, through a finite approximate analysis, that this sum is also an invariant when the fluid medium is finite, irrotational and friction-less but compressible, provided that the exciting frequencies are lower than the fundamental natural frequency of the medium. As an example this invariant has been obtained in the case of a thin flat plate for different depths of submersion and different frequency parameters by using the well-known method of `finite elements'.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250827209,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/2\/6\/421","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"GON\u00c7ALVES, E. R. Photosynthesis, osmorregulation and initial growth of four sugarcane varieties submitted to water deficiency. 2008. 66 p. Dissertation Masters degree (Agronomy Production Vegetable & Protection of Plants ) Federal University of Alagoas, Rio Largo, State of Alagoas, 2008. The water deficiency of soil is a problem that affects good part of the areas cultivated in the world, over all, to those situated ones in the half-barren regions. The sugarcane is a culture in expansion in the Northeast of Brazil, where the limitation in the water availability for the plant affects the growth and the development of the plant, causing, excessively, social and economics damages. Thus, the present work had for purpose to evaluate, in comparative way, the response of four sugarcane varieties (SP79-1011, RB72454, RB98710 and RB92579) when submitted to water stress during the initial phase of vegetative growth, aiming to identify to morphophysiological characteristics and biochemists that may serve like markers, assisting, the genetics breedings programs of the culture in the crossing process and selection of new varieties. For this, the plants had been cultivated in greenhouse of the Academic Unit Center of Agrarian Sciences, Campus Delza Gita\u00ed, of the UFAL, in Rio Largo, State of Alagoas. The study was a factorial (4 varieties x 3 levels of water based on field capacity [fc]), in completely randomized design with 5 replications. The levels of water in soil were defined like this: control (80 to 100% of fc), moderate stress (40 to 60% of fc) and severe stress (0 to 20% of fc). The analyzed variables had been: gaseous exchanges (stomatal conductance [gs], liquid photosynthesis [A] transpiration [E] and water use efficiency of the yield [WUEy]), fluorescence of chlorophyll a (Fv\/Fm), leaf water potential (\u03a8w), photosynthetic pigments, organics solutes, number of tillers, diameter and height of stem, leaf area, final number of emitted leaf and production of biomass in all the parts of the plant. The data had been submitted to the analysis of variance and the averages compared between itself for the test of Tukey, with P < 0,05. The water deficiency provoked significant reductions in gs, E, A and in the WUEy, independent of the variety. Varieties SP79-1011 and RB98710 had presented greater stomatic sensitivity, reducing gs and E to the 71 days after beginning of stress of it, even under control. However, under such conditions the A was little affected, indicating that the plants are capable to keep the photosynthetic rate with stomata closed partially. The water stress provoked a little reduction in the potential photochemistry of the studied varieties. The RB72454 kept the base \uf020 \u03a8w and midday more raised that most of varieties, independent of water condition, while the RB92579 presented the lesser values of \u03a8w under water stress conditions, indicating that the same one has ability of osmotic adjustment. The water deficiency reduced chlorophyll contents in all the varieties and it did not modify the carotenoids contents in varieties SP79-1011 and RB98710, providing to the same ones, bigger protection against the photo-oxidation. The water stress raised the levels of free proline in varieties SP79-1011, RB72454 and RB92579 and provoked reduction in the growth of the four sugarcane varieties, being that, the production of dry matter and the leaf had been more affected. The RB98710 presented increase in the relation root\/shoot when submitted to severe water stress. Key-words: Sugarcane. Water stress. Gas exchange. Fluorescence. Organics solutes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":194288532,"openaccessinfo":{"externalids":{"MAG":"2230447266","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyses Ghana's gross domestic product using time series Autoregressive Integrated Moving Average (ARIMA). Time series analysis involves the application of statistical models to time series data and is useful for analysing the dynamics of Gross domestic product. The Ghana's Gross domestic products (GDP) from 1980 to 2020 were obtained from the International Monetary Fund (IMF) datasets.\u00a0 Box Jenkins's methodology of time series analysis was employed to analyse the data.\u00a0 The autocorrelation function (ACF) and partial autocorrelation function (PACF) plot suggested an Autoregression of order one AR(1). The (ARIMA) models were obtained using the minimum AIC criteria. Model diagnostics tests were performed using Ljung-Box test. The paper established that Ghana's GDP will incline throughout the period of 2021-2025.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247347967,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.9734\/arjom\/2022\/v18i230359","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journalarjom.com\/index.php\/ARJOM\/article\/download\/507\/1013","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective This study has two aims: 1) to evaluate the apical transportation of the Wizard CD Plus and ProTaper Universal after preparation of simulated root canals; 2) to compare, with Adobe Photoshop, the ability of a new software (Regeemy) in superposing and subtracting images. Material and Methods Twenty five simulated root canals in acrylic-resin blocks (with 20\u00ba curvature) underwent cone beam computed tomography before and after preparation with the rotary systems (70 kVp, 4 mA, 10 s and with the 8\u00d78 cm FoV selection). Canals were prepared up to F2 (ProTaper) and 24.04 (Wizard CD Plus) instruments and the working length was established to 15 mm. The tomographic images were imported into iCAT Vision software and CorelDraw for standardization. The superposition of pre- and post-instrumentation images from both systems was performed using Regeemy and Adobe Photoshop. The apical transportation was measured in millimetres using Image J. Five acrylic resin blocks were used to validate the superposition achieved by the software. Student's t-test for independent samples was used to evaluate the apical transportation achieved by the rotary systems using each software individually. Student's t-test for paired samples was used to compare the ability of each software in superposing and subtracting images from one rotary system per time. Results The values obtained with Regeemy and Adobe Photoshop were similar to rotary systems (P>0.05). ProTaper Universal and Wizard CD Plus promoted similar apical transportation regardless of the software used for image's superposition and subtraction (P>0.05). Conclusion Wizard CD Plus and ProTaper Universal promoted little apical transportation. Regeemy consists in a feasible software to superpose and subtract images and appears to be an alternative to Adobe Photoshop.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16397893,"openaccessinfo":{"externalids":{"MAG":"1524916999","ACL":null,"DOI":"10.1590\/1679-775720130229","PubMedCentral":"3881847","ArXiv":null},"license":"CCBY","url":"https:\/\/www.scielo.br\/j\/jaos\/a\/xyWrgfz8PMSFXQzVHTW4GxF\/?lang=en&format=pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A high throughput, reconfigurable field programmable gate array (FPGA) implementation of the soft output Viterbi algorithm (SOVA) is described. Such a SOVA module provides the soft information needed by an iterative soft decoder used with Turbo codes and low density parity check (LDPC) codes. The implementation of the SOVA algorithm runs at 100 Mb\/s on Xilinx Virtex II 2000 FPGA. Using a higher capacity FPGA and repeating the circuit doubles the throughput. The design can be reconfigured for different partial response (PR) targets. The design requires about 5 kb of memory for the EPR4 channel and may be integrated on a single chip with serially implemented LDPC decoder.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":30662170,"openaccessinfo":{"externalids":{"MAG":"2129691410","ACL":null,"DOI":"10.1109\/TMAG.2004.832672","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Systematic electron microscopy of quasi crystals in an Al-14 at % Mn alloy has been carried out. High resolution imaging reveals fringes with spacings in the ratio of 1:\u03c4. Besides 5-3-2 synnetry axes, other important zones of electron diffraction patterns are experimentally determined and compared with those generated by Landau grneration technique and by projection technique. It has been shown that the 'T' phase, which often co-exits with quasicrystal, is closely related to it and can be treated as a two dimensional quasiperiodic crystal stacked periodically along an icosahedral vector of a true quasi periodic incommensurate modulation in three, two and one dimensions. The quasi crystal, the 'T' phase and vacancy ordered \u03c4 phases and the respective real life examples of such modulations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137630346,"openaccessinfo":{"externalids":{"MAG":"948102836","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Events leading to the adoption of voice telephone lines for air-defense operational messages are described. This process paved the way for the use of operational data lines in the SAGE (Semi-Automatic Ground Environment) system. The paper describes the early considerations leading to the use of a digital computer in SAGE, and how Whirlwind was chosen to be that computer. The context of the development of magnetic core memory is illuminated. The attitudes of engineering professionals toward digital equipment are reviewed. The author reveals how the name \"Ground Environment\" was created.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":30320780,"openaccessinfo":{"externalids":{"MAG":"2011098560","ACL":null,"DOI":"10.1109\/MAHC.1985.10030","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Synthetic Aperture Radar (SAR) is a coherent imaging radar. Hence, coherence is critical in SAR imaging. In a coherent system, several sources can degrade performance. Based on the HJ-1-C SAR system implementation and sensor characteristics, this study evaluates the effect of frequency stability and pulse-to-pulse timing jitter on the SAR coherent performance. A stable crystal oscillator with short-term stability of 10 1.0 10 5 ms \/ \u2212 \u00d7 is used to generate the reference frequency by using a direct multiplier and divider. Azimuth ISLR degradation owing to the crystal oscillator phase noise is negligible. The standard deviation of the pulse-to-pulse timing jitter of HJ-1-C SAR is lower than 2ns (rms) and the azimuth random phase error in the synthetic aperture time slightly degrades the side lobe of the azimuth impulse response. The mathematical expressions and simulation results are presented and suggest that the coherent performance of the HJ-1-C SAR system meets the requirements of synthetic aperture radar imaging.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":115000112,"openaccessinfo":{"externalids":{"MAG":"2564971923","ACL":null,"DOI":"10.3724\/sp.j.1300.2014.13060","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present generalized supernova (SN) light curve (LC) models for a variety of power inputs including the previously proposed ideas of radioactive decay of 56Ni and 56Co and magnetar spin-down. We extend those solutions to include finite progenitor radius and stationary photospheres as might be the case for SN that are powered by interaction of the ejecta with circumstellar matter (CSM). We provide an expression for the power input that is produced by self-similar forward and reverse shocks that efficiently convert their kinetic energy into radiation. We find that this ejecta\u2013CSM interaction luminosity that we derive is in agreement with results from multi-dimensional radiation hydrodynamics simulations in the case of an optically thin CSM. We develop a semi-analytical model for the case of an optically thick CSM by invoking an approximation for the effects of radiative diffusion similar to that adopted by Arnett for SN II and compare this model to the results of numerical radiation hydrodynamics models. This model can give complex LCs, but for monotonically declining shock input, the LCs have a smooth rise, peak, and decline. In the context of this model, we provide predictions of the shock breakout of the forward shock from the optically thick part of the CSM envelope. We also introduce a hybrid LC model that incorporates ejecta\u2013CSM interaction plus 56Ni and 56Co radioactive decay input. We fit this hybrid model to the LC of the super-luminous supernova (SLSN) 2006gy. We find that shock heating produced by ejecta\u2013CSM interaction plus some contribution from radioactive decay provides a better fit to the LC of this event than previously presented models. We also address the relation between SN IIL and SN IIn with ejecta\u2013CSM interaction models. The faster decline of SN IIL can be reproduced by the diffusion of previously deposited shock power if the shock power input to the diffusive component vanishes when the reverse shock sweeps up the whole ejecta and\/or the forward shock propagates through the optically thick CSM. A CSM interaction with forward and reverse shock power input can produce the LCs of SN IIn in terms of duration, shape, and decline rate, depending on the properties of the CSM envelope and the progenitor star. This model can also produce LCs that are symmetric in shape around peak luminosity, which is the case for the observed LCs of some recently discovered peculiar transient events. We conclude that the observed LC variety of SN IIn and of some SLSNe is likely to be a byproduct of the large range of conditions relevant to significant ejecta\u2013CSM interaction as a power source.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":118375572,"openaccessinfo":{"externalids":{"MAG":"1976714811","ACL":null,"DOI":"10.1088\/0004-637X\/746\/2\/121","PubMedCentral":null,"ArXiv":"1111.5237"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As its title suggests, this book deals with the marriage of two well-known topics. Scaled versions of fractal geometrical objects possess certain congruence properties, usually called self-similarities. Point processes are mathematical models of the occurrence of discrete events in time, space, or some other arena. Due to a degree of incompatibility between the partners, this is not an easy marriage. Points, by definition, have no extension and are invariant under shift or scale transformations, so fractality can reside only in the distribution of the points. The approach of this book is to exploit scaling behavior of such distributions and the concomitant power-law behavior of their statistical summaries. The unnaturalness of continuous mathematical descriptors of discrete processes is most evident when one is dealing with real-world measurements. It is probably for this reason that there are not many effective data analysis techniques. Chapter 2 is a succinct, clear introduction to fractals. A reader completely new to the concepts might need to turn to other books, such as those meticulously referenced by the authors. My favorite is the no-nonsense book of Feder (1988). The next two chapters nicely describe several representations of point processes (based on event times, intervals between events, and counts of events in bins), a number of statistical quantities that characterize the processes, and numerous examples: homogeneous Poisson, renewal, doubly stochastic Poisson, integrate-and-reset, cascaded, and branching point processes. Of special interest for subsequent discussions, and probably new to many readers, is the normalized Haar-wavelet variance. Apparently first introduced by Allan in 1966, I as well as others have used this measure to characterize time series data that appear to be self-scaling, and modeled as \"1\/f noise processes\" (Scargle et al. 1993). The terms scalegram or wavelet spectrum is often used (see Abry, Goncalves, and Flandrin 1995) and Flandrin (1999) for excellent mathematical discussions. Chapter 5 leads off the main content of the book, introducing the concept of fractal point processes. As mentioned above, the approach is indirect: the scaling properties of the statistical measures introduced in Chapter 2 define fractal behavior in point processes. Elaboration of this idea relies on the strong connection between power-law behavior of the measures, as functions of time, and the appropriate scaling behavior. This key chapter and its exercises make connections among a whole collection of measures of point process fractal behavior. For example, the wavelet variance and power spectrum express similar information about how variability depends on scale: they capture the self-similarity of fractal processes through the well-known \"1\/f \u03b1 \" power-law dependence (on time scale or frequency, resp.). They also have similar ways of revealing what is sometimes called the noise floor at short time scales or high frequencies. The authors also follow a canonical set of fractal-based point processes through all of the measures (and transformations in Chap. 11) to help identify similarities and general behavior. Subsequent chapters treat special classes: fractal Brownian motion, renewal, alternating renewal, shot noise, and shot-noise-driven processes, all of considerable interest is a number of the sciences. Chapter 11 discusses a number of interesting ways that one point process can be transformed to another. These procedures are useful in randomization procedures (e.g., bootstrap methods) of various kinds. After a sad-but-true litany of the reasons that identification of fractal-based point processes is difficult or impossible, Chapter 12 studies estimation of parameters in the representations introduced earlier in the book, and the performance of the estimators. The final chapter, Computer Network Traffic, can be considered as a case study for the general reader, and presumably is of more specialized interest to computer scientists and telecommunications technologists. Each chapter ends with numerous problems suitable for students at various levels. There are three appendices containing derivations, problem solutions, and a list of symbols. Errata and addenda, C program source code, and data sets can be found at the authors' website http:\/\/cordelia.mclean.org\/~lowen\/fbpp.html, and the book is also available for purchase from the publishers in e-book form. It is hard to find fault with this carefully crafted book. My only significant disappointment was with the paucity of practical methods for data analysis. Presumably in a course, students will learn computational methods from problems and computer laboratory assignments. Frankly, I did not pay much attention to the exercises included. The authors' point of view is that the most powerful data analytic tools are the normalized Haar wavelet variance and the power spectrum. A reader interested in computing estimates of these descriptors should consult the code provided at the above website. Furthermore, one should take seriously the fact that there are important limitations in the current state of knowledge and, as pointed out by the authors, there are inherent mathematical difficulties, especially in the area of identification. The comment \"Count-number statistics also provide the only systematic analysis approach available for spaces of dimension greater than one\" in Section 3.4 short-changes recent progress using generalizations of point-based representations and their statistics in the fields of stochastic geometry (Stoyan, Kendall, and Mecke 1995) and computational geometry. For example, Voronoi cells of data points are slick estimators of local density and its gradient, and have been used in segmentation analysis of 3D data on the distribution of galaxies in the Universe (Scargle, Jackson, and Norris 2003; see also Scargle and Babu 2003) and no doubt will play a role in research into scaling properties of this distribution. These objections are quite minor. All in all, this is an excellent exposition of a cutting-edge topic, and will be extremely valuable as a textbook and for scientists in diverse fields, including astronomy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10262170,"openaccessinfo":{"externalids":{"MAG":"2056406481","ACL":null,"DOI":"10.1198\/tech.2007.s453","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Collagen is the most abundant protein in the extracellular matrix (ECM), where its structural organization conveys mechanical information to cells. Using optical-tweezers-based microrheology, we investigated mechanical properties both of collagen molecules at a range of concentrations in acidic solution where fibrils cannot form and of gels of collagen fibrils formed at neutral pH, as well as the development of microscale mechanical heterogeneity during the self-assembly process. The frequency scaling of the complex shear modulus even at frequencies of \u223c10 kHz was not able to resolve the flexibility of collagen molecules in acidic solution. In these solutions, molecular interactions cause significant transient elasticity, as we observed for 5 mg\/ml solutions at frequencies above \u223c200 Hz. We found the viscoelasticity of solutions of collagen molecules to be spatially homogeneous, in sharp contrast to the heterogeneity of self-assembled fibrillar collagen systems, whose elasticity varied by more than an order of magnitude and in power-law behavior at different locations within the sample. By probing changes in the complex shear modulus over 100-minute timescales as collagen self-assembled into fibrils, we conclude that microscale heterogeneity appears during early phases of fibrillar growth and continues to develop further during this growth phase. Experiments in which growing fibrils dislodge microspheres from an optical trap suggest that fibril growth is a force-generating process. These data contribute to understanding how heterogeneities develop during self-assembly, which in turn can help synthesis of new materials for cellular engineering.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9868988,"openaccessinfo":{"externalids":{"MAG":"2053808972","ACL":null,"DOI":"10.1371\/journal.pone.0070590","PubMedCentral":"3732230","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0070590&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Ad-hoc radio networks and multiple access channels are classical and well-studied models of distributed systems, with a large body of literature on deterministic algorithms for fundamental communications primitives such as broadcasting and wake-up. However, almost all of these algorithms assume knowledge of the number of participating nodes and the range of possible IDs, and often make the further assumption that the latter is linear in the former. These are very strong assumptions for models which were designed to capture networks of weak devices organized in an adhoc manner. It was believed that without this knowledge, deterministic algorithms must necessarily be much less efficient. In this paper we address this fundamental question and show that this is not the case. We present deterministic algorithms for blind networks (in which nodes know only their own IDs), which match or nearly match the running times of the fastest algorithms which assume network knowledge (and even surpass the previous fastest algorithms which assume parameter knowledge but not small labels). Specifically, in multiple access channels with k participating nodes and IDs up to L, we give a wake-up algorithm requiring O( k log L log k log log k ) time, improving dramatically over the O(L log L) time algorithm of De Marco et al. (2007), and a broadcasting algorithm requiring O(k log L log log k) time, improving over the O(L) time algorithm of G\u0105sieniec et al. (2001) in most circumstances. Furthermore, we show how these same algorithms apply directly to multi-hop radio networks, achieving even larger running time improvements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208097279,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To the Editor: \u2014Although the annual reports of hospitals are valuable sources of information concerning certain hospital activities, they are strangely silent in relation to one of the major aspects of hospital service; namely, the gratuitous service of physicians which is bound up with ordinary hospital practice. Those who have been identified with hospital administration and have shared in the preparation of hospital reports know that the omission is due to thoughtlessness and not to any desire to conceal a vital fact in medicosocial economics. Nevertheless, it is high time for hospitals to mend their ways. I shall not attempt here to discuss the question whether the members of active staffs of hospitals and dispensaries are sufficiently rewarded for their services in the free wards and the dispensary by the enhancement of their professional prestige, by privileged access to research laboratories, by preferential right to the use of rooms for","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":72349156,"openaccessinfo":{"externalids":{"MAG":"2088870799","ACL":null,"DOI":"10.1001\/jama.1932.02740700070035","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Mining informative patterns from databases is the historical task of data mining. But now, mining actionable patterns is becoming the new duty of data mining. Most of machine learning and data mining algorithms only focus on finding patterns and usually don't take any step for suggesting actions and users will be responsible for it. Therefore users will be faced with many patterns that they are confused about how and what to do with them. So that extracting actionable knowledge from database, to offer actions that lead to an increase in profit is very critical. \nUp to now few works have been done in this field and they usually suffer from drawbacks such as incomprehensibility to the user, neglecting cost, not providing rule generality. Here we attempt to present a method to resolving these issues. In this paper CEARDM method is proposed to discovering cost-effective action rules from data. These rules offer some cost-effective changes to transferring low profitable instances to higher profitable ones.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":107336327,"openaccessinfo":{"externalids":{"MAG":"99876100","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: The COVID-19 pandemic, caused by the novel coronavirus 2 (SARS-CoV-2), has been associated with an increased risk of secondary bacterial infections. Numerous studies have reported a surge in antibiotic usage during the COVID-19 pandemic. This study aims to examine the impact of the COVID-19 pandemic on the frequency and patterns of antibiotic prescriptions at Primary Health Care Centers (PHCC) in Qatar, comparing the period before and during the pandemic. Methods: This population-based, cross-sectional study analyzed all antibiotic prescriptions issued in two-month intervals before COVID-19 (November and December 2019) and during the initial wave (June and July 2020) of COVID-19. The study included 27 PHCCs in Qatar. Results: Prior to the COVID-19 outbreak, the PHCCs dispensed a total of 74,909 antibiotic prescriptions in November and December. During the first wave of COVID-19, the number decreased to 29,273 prescriptions in June and July 2020. Antibiotics were most commonly prescribed for adults and least commonly for the elderly, both before and during the COVID-19 period. In the pre-COVID-19 period, Betalactams and macrolides accounted for the majority (73%) of all antibiotic prescriptions across all age groups. However, during the COVID-19 period, Betalactams and other antibiotics such as Nitrofurantoin and Metronidazole (73%) were the most frequently prescribed. Conclusion: The rate of antibiotic prescriptions during the first wave of COVID-19 was lower compared to the two months preceding the pandemic at the PHCC in Qatar.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260217357,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/antibiotics12081228","PubMedCentral":"10451533","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2079-6382\/12\/8\/1228\/pdf?version=1690277253","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: To assess and correlate early modifications in hyperreflective retinal spots (HRS), retinal sensitivity (RS), fixation stability, and best-corrected visual acuity (BCVA) after anti-vascular endothelial growth factor treatment in naive center-involving diabetic macular edema. Methods: Cross-sectional comparative case\u2013control series. Twenty diabetic patients underwent 3 consecutive intravitreal anti-vascular endothelial growth factor injections in the study eye (20 fellow eyes served as control), full ophthalmologic examination including spectral domain optical coherence tomography (Retinascan RS-3000; Nidek, Gamagori, Japan), and microperimetry (MP1; Nidek) at baseline (Visit-V1), 1 month after each injection (V2, V3, V4), and at 6 months (V5). Central retinal thickness, inner and outer retinal thickness, number of HRS, BCVA, RS, and bivariate contour ellipse area were evaluated by analysis of variance test with Bonferroni post hoc test. Correlation analyses were performed by Spearman correlation. Results: In treated eyes, central retinal thickness and inner retinal thickness significantly decreased at V2, V3, V4 versus V1 (P < 0.03 at least for all); the mean number of HRS significantly decreased in both inner and outer retina at all follow-up visits versus V1 (P < 0.008 at least for all); mean RS and bivariate contour ellipse area remained statistically unchanged during the follow-up; BCVA significantly improved at V3, V4, and V5 versus V1 (P = 0.009 at least for all). In fellow eyes, central retinal thickness, HRS, RS, and BCVA did not change at any follow-up. The number of HRS correlated inversely with RS, directly with bivariate contour ellipse area, and not significantly with BCVA. Conclusion: A significant decrease in HRS in the retina after anti-vascular endothelial growth factor treatment is documented. A decrease in HRS correlates with functional parameters, specifically RS. New parameters may be used for treatment evaluation in center-involving diabetic macular edema.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":46037070,"openaccessinfo":{"externalids":{"MAG":"2322106283","ACL":null,"DOI":"10.1097\/IAE.0000000000000912","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The inactivation of dinoflagellate Scrippsiella trochoidea in synthetic ballast water by a dielectric barrier discharge (DBD) system was investigated. The radical, ozone and hydrogen peroxide generated from the DBD system were measured. Before and after the treatment, the viability of dinoflagellate S. trochoidea was evaluated by analyzing chlorophyll a, protein and saccharide content and morphology of the cells, as well as the pH of the cell culture media. The results show that radical was the major reactive species when humid air was used. The inactivation of S. trochoidea was found to be dependent on the applied voltage and the gas flow rate, and was completed within 4\u2009min at a gas flow rate of 7\u2009L\u2009min\u22121 and an applied voltage of 20\u2009kV. The change of chlorophyll a, protein and saccharide concentrations of S. trochoidea and the morphology of the cells indicates that the reactive species generated from the DBD system can break up the cells via oxidation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250736096,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/42\/9\/095203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Simple Summary Endoscopic submucosal dissection (ESD) is accepted as a standard treatment for early gastric cancer (EGC). Non-curative resection (NCR) of EGC after ESD can increase the burden of additional treatment and medical expenses. Thus, we aimed to develop a machine-learning (ML)-based NCR prediction model for EGC prior to ESD. We obtained data from 4927 patients with EGC who underwent ESD between January 2006 and February 2020. Seven ML-based NCR prediction models were developed using ten clinicopathological characteristics. The performance of NCR prediction was highest in the XGBoost model (AUROC, 0.851; 95% confidence interval, 0.837\u20130.864). Our ML model improved the ability to predict NCR of ESD in patients with EGC. This ML model can provide useful information for decision-making regarding the appropriate treatment of EGC before ESD. Abstract Non-curative resection (NCR) of early gastric cancer (EGC) after endoscopic submucosal dissection (ESD) can increase the burden of additional treatment and medical expenses. We aimed to develop a machine-learning (ML)-based NCR prediction model for EGC prior to ESD. We obtained data from 4927 patients with EGC who underwent ESD between January 2006 and February 2020. Ten clinicopathological characteristics were selected using extreme gradient boosting (XGBoost) and were used to develop a ML-based model. Dataset was divided into the training and internal validation sets and verified using an external validation set. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC) were evaluated. The performance of each model was compared by using the Delong test. A total of 1100 (22.1%) patients were identified as being treated non-curatively with ESD. Seven ML-based NCR prediction models were developed. The performance of NCR prediction was highest in the XGBoost model (AUROC, 0.851; 95% confidence interval, 0.837\u20130.864). When we compared the prediction performance by the Delong test, XGBoost (p = 0.02) and support vector machine (p = 0.02) models showed a significantly higher performance among the NCR prediction models. We developed an ML model capable of accurately predicting the NCR of EGC before ESD. This ML model can provide useful information for decision-making regarding the appropriate treatment of EGC before ESD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251272025,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/cancers14153742","PubMedCentral":"9367410","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6694\/14\/15\/3742\/pdf?version=1659534829","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Polymeric coatings manufactured by thermal spray processes exhibit variable mechanical and adhesion properties that depend on their exact processing schedules. One important advantage of these coatings is that they can be readily repaired by re-spraying any delaminated or otherwise defective regions. In some instances the repaired region exhibits better mechanical attributes than the original coating. In this study the repairability of several classes of polymeric and polymer-ceramic composite coatings were investigated with a focus on the interfacial adhesion properties. The coatings include those of monolayer and bilayer ethylene methacrylic acid (EMAA), and CaCO3-EMAA composites. The coating thickness did not influence the interfacial adhesive strength between the coating and substrate; while a higher preheat temperature produced a greater interfacial cohesion for the monolayer coating on a metal substrate. The substrate preheat temperature played a dominant role concerning the peel strength of the coating. Greater peel strengths were achieved between polymers, at least twofold greater than that between the polymer and the steel substrate when the pre-heat temperature was greater than the melting point of the polymer. The peel strength of the composite coating decreased with filler content; both on the steel substrate and on a previously sprayed polymer coating. On the basis of these observations, the adhesion mechanism between polymers was explained with a model that relied on the formation of welding points.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":138414161,"openaccessinfo":{"externalids":{"MAG":"2248352815","ACL":null,"DOI":"10.31399\/asm.cp.itsc2005p0074","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Now a day's Natural Fibres Composites owing importance due to its Bio degradability, Light weight& Strength etc ., This project aims to investigate Mechanical Property evaluation of Jute fibre Eglassfiber, without chemical treatment and applied an compression load on the Jute fibre layers to be in uniform and Unidirectional. To evaluate the mechanical properties and weights of specimens are2 and 3 layeerstaken, Epoxy & Hardener constant for all specimens. The Specimens prepared by Hand layup technique and specimen cuts with Manual Hacksaw frame and applied smooth filing to avoid notches during cutting. Testing's for Mechanical properties evaluation used are tensile, and 3-Point Flexural testing's on computerized UTM (INSTRON 3369). Hardness and Impact tests also performed per the ASTM standards.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234706021,"openaccessinfo":{"externalids":{"MAG":"3113603971","ACL":null,"DOI":"10.32628\/ijsrset207378","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32628\/ijsrset207378","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aim: The aim of this study was to find out and to compare the effect of cholecystectomy performed due to gallstone on the extrahepatic bile ducts morphometry in diabetic and non-diabetic patients. Material and Methods: Three groups consisting of a total of 120 individuals. Diabetic patients with cholelithiasis (DC group) consisted of 40 person, non-diabetic patients with cholelithiasis (N-DC group) consisted of 40 person and healthy group (H group) consisted of 40 person. Laparoscopic cholecystectomy was performed on individuals with cholelithiasis. DHC (ductus hepaticus communis) diameter was measured below hepatic canal bifurcation from mucosa to mucosa by ultrasonography. The measurements were conducted in preoperative period and in the third and sixth postoperative months. Results: There were no significant differences between DC and N-DC groups in terms of DHC diameters in preoperative period and postoperative third and sixth months. In both DC and N-DC groups, DHC diameters in postoperative third and sixth months were found to show a small but statistically significant increase. Conclusion: This study showed a small but statistically significant dilatation in DHC following cholecystectomy. In addition, no statistically significant difference was found between DC and N-DC groups in terms of postcholecystectomy DHC dilatation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":226746015,"openaccessinfo":{"externalids":{"MAG":"3082450969","ACL":null,"DOI":"10.5455\/annalsmedres.2020.02.149","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Clear as glass: The atomic structure of a metal-supported vitreous thin silica film was resolved using low-temperature scanning tunneling microscopy (STM). Based on the STM image, a model was constructed and the atomic arrangement of the thin silica glass determined (see picture). The total pair correlation function of the structural model shows good agreement with diffraction experiments performed on vitreous silica.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38614430,"openaccessinfo":{"externalids":{"MAG":"2105240031","ACL":null,"DOI":"10.1002\/anie.201107097","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Non-polar and polar lipids were isolated from Methanopyrus kandleri. Non-polar lipids accounted for 50% w\/w of total lipids, with a high proportion of 2,3-di-O-geranylgeranyl-sn-glycerol, 2,3-di-O-phytanyl-sn-glycerol and geranylgeraniol. The core lipids prepared by mild acid methanolysis consisted exclusively of 2,3-di-O-phytanyl-sn-glycerol. Two-dimensional TLC showed mostly glycolipids, and minor amounts of aminophospholipids, phosphoglycolipids and phospholipids. The purification yielded three diglycosyl-lipids (50% of total polar lipids), one triglycosyl-lipid (5%) and six glycosyl-lipids with five glycosyl-groups (36%), which consisted of glucose, galactose and mannose. The lipid analysis supports the unique position of Methanopyrus kandleri within the 16S rRNA-based phylogenetic tree.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":84513635,"openaccessinfo":{"externalids":{"MAG":"2044840175","ACL":null,"DOI":"10.1111\/J.1574-6968.1996.TB08049.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This presentation will highlight the role of a Technology Enhanced Learning (TEL) community in a university-wide \nVirtual Learning Environment (VLE) roll-out. The community helped to reveal that inconsistent use of the VLE caused \ndissatisfaction. The community's participation was formally recognised as the 'Canvas team' and new course and \nmodule 'templates' were designed and implemented to ensure consistent use of the VLE. The aim of this presentation \nis to discuss the role of the TEL community in bridging the gap between the theory and practice, beyond the roll-out \nand using early student evaluation data analysis.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":69790620,"openaccessinfo":{"externalids":{"MAG":"2901577614","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose To compare amniotic membrane transplantation (AMT) associated with narrow-strip conjunctival autograft vs conjunctival autograft alone for the treatment of recurrent pterygium. Methods In this prospective consecutive interventional study, patients with recurrent pterygium were randomly divided into one of 2 groups; group 1: patients undergoing AMT associated with autologous conjunctival graft; and group 2: patients undergoing conjunctival autograft alone. Results Of the 80 operated eyes included in this study, 39 (group 1, mean patient age 52.1 \u00b1 11.7 SD years) underwent AMT associated with narrow-strip conjunctival autograft and 41 (group 2, mean patient age 45.8 \u00b1 12.9 SD years) underwent conjunctival autograft alone. In group 1, 6 eyes (15.4%) had grade 1 pterygium, 19 eyes (48.7%) had grade 2 pterygium, and 14 eyes (35.9%) had grade 3 pterygium. In the second group, 5 eyes (12.2%) had grade 1 pterygium, 18 eyes (43.9%) had grade 2 pterygium, and 14 eyes (35.9%) had grade 3 pterygium. No statistically significant difference was found between the 2 groups (p = 0.752). Of the 39 eyes in group 1, recurrent pterygium was observed in 7 cases (17.9%). However, of the 41 eyes in group 2, recurrent pterygium was observed in only 4 cases (9.75%). No statistically significant difference was found between the 2 groups (p = 0.2684). Conclusions The results of this study indicate that conjunctival autograft alone might be a better surgical choice for the treatment of recurrent pterygia than combining it with AMT; however, this second option provides a good surgical alternative in cases where little conjunctival donor tissue is available.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43752236,"openaccessinfo":{"externalids":{"MAG":"2469293680","ACL":null,"DOI":"10.5301\/ejo.5000773","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Computational searching and screening of new functional materials exploiting Earth abundant elements can accelerate the development of their energy applications. Based on the state-of-the-art material search algorithm and ab initio calculations, we demonstrate a recently suggested stable silicon oxide with a layered structure (Si3O) as an ideal photovoltaic material. With many-body first-principles approaches, the monolayer and layered bulk of Si3O show direct quasiparticle gaps of 1.85 eV and 1.25 eV, respectively, while an optical gap of about 1.2 eV is nearly independent of the number of layers. Spectroscopic limited maximum efficiency (SLME) is estimated to be 27% for a thickness of 0.5 \u03bcm, making it a promising candidate for solar energy applications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220670551,"openaccessinfo":{"externalids":{"MAG":"3104951855","ACL":null,"DOI":"10.1039\/D0NR03297B","PubMedCentral":null,"ArXiv":"2008.02654"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fiber-reinforced ceramics (ceramic matrix composites (CMCs)) with uncoated alumina oxide fibers in a porous alumina oxide matrix represent a group of materials with high application potential and future importance. In most cases, a grinding process is necessary to fulfill surface and tolerance requirements. However, the machining characteristics of CMCs with a porous alumina oxide matrix and the underlying material removal mechanisms are not investigated yet. It has been shown that ductile grinding, requiring plastic deformation, of monolithic alumina oxide is possible. It is not known, if the existing knowledge regarding the grinding characteristics of monolithic alumina oxide can be transferred to CMCs with a porous alumina oxide matrix. Hence, the research question of this paper is whether a ductile grinding and thus plastic deformation of this CMC type is possible or only brittle material behavior is present. \u00a9 2017 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the scientific committee of the International Conference on the Technology of Plasticity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59417448,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This book provides a comprehensive investigation of the messy and crisis-ridden relationship between the operations of capitalist finance, global capital flows, and state power in emerging markets. The politics, drivers of emergence, and diversity of these myriad forms of state power are explored in light of the positionality of emerging markets within the network of space and power relations that characterises contemporary global finance. The book develops a multi-disciplinary perspective and combines insights from Marxist political economy, post-Keynesian economics, economic geography, and postcolonial and feminist International Political Economy. Alami comprehensively reviews the theories, histories, and geographies of cross-border finance management, and develops a conceptual framework which allows unpacking the complex entanglement of constraint and opportunities, of growing integration and tight discipline, that cross-border finance represents for emerging markets. Extensive fieldwork research provides an in-depth comparative critical interrogation of the policies and regulations deployed in Brazil and South Africa. This volume will be especially useful to those researching and working in the areas of international political economy, contemporary geographies of money and finance, and critical development studies. It should also prove of interest to policy makers, practitioners, and activists concerned with the relation between finance and development in emerging markets and beyond.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":211742154,"openaccessinfo":{"externalids":{"MAG":"2979131421","ACL":null,"DOI":"10.4324\/9780429297106","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Environmentally conscious supplier selection has become increasingly important in recent years. Green supplier selection is one of the vital decisions of supply chain management, as it is preferred for businesses in the market that adopt an environmental approach and green philosophy in line with material and moral benefits. In this context, the problem of choosing the most efficient green supplier is addressed with a three-step methodology using big data analytics that includes an integrated approach and hybrid fuzzy AHP-TOPSIS techniques. First of all, big data plays an important role in delivering meaningful results by reducing complexity to a more fundamental level. It is possible to obtain more consistent results by examining a series of criteria in green supplier selection at a more reasonable and operational level. Thus, the role of big data analytics provides an input for decision-making, which enables a systematic reduction to more concise data. Then, these inputs are evaluated in a fuzzy environment with hybrid MCDM techniques and the most efficient green supplier is determined among the suppliers. This authentic study sheds light on providing a significant competitive advantage to businesses in line with their strategic targets as well as having environmental contributions to sustainability. Graphical abstract","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":234839888,"openaccessinfo":{"externalids":{"MAG":"3154991537","ACL":null,"DOI":"10.21203\/RS.3.RS-330269\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Control of a two link planar manipulator with one flexible link executing constrained and unconstrained maneuvers is considered in this study. The dynamic model includes the impact force generated during the transition from unconstrained to constrained segment of the robotic task. The linear quadratic Gaussian\/loop transfer recovery (LQG\/LTR) design methodology is exploited to design a robust feedback control system that can handle modelling errors and sensor noise, and operate on Cartesian space trajectory errors. The LQG\/LTR compensator together with a feedforward loop is used to control the flexible manipulator. Simulated results are presented for a numerical example.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1,"unknown":2}},"corpusid":6050691,"openaccessinfo":{"externalids":{"MAG":"1522522931","ACL":null,"DOI":"10.1109\/ACC.1991.4174723","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Synopsis On the basis of a literature review it is concluded that mass hysteria can be divided into two syndromes. One form, to be called 'mass anxiety hysteria', consists of episodes of acute anxiety, occurring mainly in schoolchildren. Prior tension is absent and the rapid spread is by visual contact. Treatment consists of separating the participants and the prognosis is good. The second form, to be called 'mass motor hysteria', consists of abnormalities in motor behaviour. It occurs in any age group and prior tension is present. Initial cases can be identified and the spread is gradual. Treatment should be directed towards the underlying stressors but the outbreak may be prolonged. In mass anxiety hysteria the abnormality is confined to group interactions; in mass motor hysteria abnormal personalities and environments are implicated.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-30":1,"unknown":2}},"corpusid":32597423,"openaccessinfo":{"externalids":{"MAG":"2029155460","ACL":null,"DOI":"10.1017\/S0033291700013027","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The context of this work is that of systems being able to produce a collective response from interaction between simple individuals. Such systems are qualified of self organized ones and can be modeled with reactive multi-agent systems. This article underlines why, from our point of view, the analysis of these systems requires an experimental approach and it details our proposition in terms of tools for experimentations. After commenting each main components of the platform, it provides some details about its current implementation in the case of two systems.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":18499160,"openaccessinfo":{"externalids":{"MAG":"996370256","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The medullary carcinoma of the thyroid plays a special role among the thyroid carcinomas due to his histiogenesis and endocrinologic behaviour. The symptoms like familiar occurrence, simultaneous pheochromocytoma, calcitonin-production, para-neoplastic syndroms with ACTH-production and the commonly associated diarrhea are discussed. The biological behavior of the tumor is presented reviewing the literature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42583573,"openaccessinfo":{"externalids":{"MAG":"2405546182","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report precision atmospheric spectroscopy of CO2 using a laser heterodyne radiometer (LHR) calibrated with an optical frequency comb. Using the comb calibrated LHR, we record spectra of atmospheric CO2 near 1572.33\u2009nm with a spectral resolution of 200\u2009MHz, using sunlight as a light source. The measured CO2 spectra exhibit frequency shifts by approximately 11\u2009MHz over the course of the 5-h measurement, and we show that these shifts are caused by Doppler effects due to wind along the spectrometer line of sight. The measured frequency shifts are in excellent agreement with an atmospheric model, and we show that our measurements track the wind-induced Doppler shifts with a relative frequency precision of 2\u2009MHz (3\u2009m\u00b7s-1) for a single 10\u2009s measurement, improving to 100\u2009kHz (15\u2009cm\u00b7s-1) after averaging (equivalent to a fractional precision of a few parts in 1010). These results demonstrate that frequency comb calibrated LHR enables precision velocimetry that can be of use in applications ranging from climate science to astronomy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259924773,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1364\/OL.500652","PubMedCentral":null,"ArXiv":"2307.07441"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE: To evaluate the effect of thymectomy in the treatment of late-onset myasthenia gravis (MG) in the elderly. METHODS: Twenty-three such cases receiving thymectomy were followed up. RESULTS: MG was more frequent in male patients in the elderly, with generalized MG more prevalent that was often complicated by thymoma and myasthenia crisis. The total effective rate of the surgical intervention was 43.5 %. CONCLUSION: Thymectomy is applicable in late-onset MG in the elderly in spite of the fact that its effect is not as good as that in younger patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":75953996,"openaccessinfo":{"externalids":{"MAG":"2354261773","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate the role of Q-CSIT in SM-MISO for wireless sensor networks system. The SN are connected to the CH, it is modeled as a MISO system. Spatial modulation has an advantage over a conventional MIMO system which does not require multiple radio frequency chains as many as the number of transmit antennas. The Q-CSIT is aimed to estimate the faded wireless channel with a limited\/finite number of bits. The finite number of feedback bits trigger the SN adapt automatically its AMC modes. Adaptation of the AMC modes causes a changing of transmit power and transmission rate, these changes will make a better probability of error. The numerical results show that bigger the number of feedback bits yields better SER. Furthermore, lower spatial correlation generates a better probability of error. The last, quality of wireless channel that is stated in SNR also dominantly influences the performance of SM - MISO system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":211056468,"openaccessinfo":{"externalids":{"MAG":"3003382088","ACL":null,"DOI":"10.23919\/EECSI48112.2019.8976976","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0We evaluate the hypothesis that sea-level rise over the second half of the 20th century has led to detectable increases in Chesapeake Bay salinity. We exploit a simple, statistical model that predicts monthly mean salinity as a function of Susquehanna River flow in 23 segments of the main stem Chesapeake Bay. The residual (observed minus modeled) salinity exhibits statistically significant linear (p < 0.05) trends between 1949 and 2006 in 13 of the 23 segments of the bay. The salinity change estimated from the trend line over this period varies from \u22122.0 to 2.2, with 10 of the 13 cells showing positive changes. The mean and median salinity changes over all 23 cells are 0.47 and 0.72; over the 13 cells with significant trends they are 0.71 and 1.1. We ran a hydrodynamic model of the bay under present-day and reduced sea level conditions and found a bay-average salinity increase of about 0.5, which supports the hypothesis that the salinity residual trends have a significant component due to sea-level rise. Uncertainties remain, however, due to the spatial and temporal extent of historical salinity data and the infilling of the bay due to sedimentation. The salinity residuals also exhibit interannual variability, with peaks occurring at intervals of roughly 7 to 9 years, which are partially explained by Atlantic Shelf salinity, Potomac River flow and the meridional component of wind stress.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":128761206,"openaccessinfo":{"externalids":{"MAG":"2076686801","ACL":null,"DOI":"10.1029\/2007JC004247","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50% at a concentration of 0.6 microM compared with 8 microM for U74006F, 28 microM for alpha-tocopherol, and 43 microM for the ring portion of alpha-tocopherol (i.e., trolox). U78517F is devoid of hypothermic or antiexcitotoxic actions or interactions with known neurotransmitter receptors. When administered intraperitoneally to male gerbils at 10 minutes before and again at the end of a 3-hour period of unilateral carotid artery occlusion, U78517F decreased 24-hour postischemic cortical neuronal necrosis. Neuronal density in the medial portion of the cortex was increased from 34.2% of normal in vehicle-treated animals to 86.3% in the U78517F-treated animals. In the lateral cortical area, the vehicle group showed only 3.3% neuronal survival versus 48.2% in the drug-treated group. In a separate series of experiments with the same focal ischemia model, identical dosing with U78517F enhanced the postischemic recovery of cortical extracellular calcium without any effect on ischemic or postischemic cortical blood flow. The effect on calcium recovery was observed at intraperitoneal doses as low as 0.1 mg\/kg. The compound also was effective in partially attenuating 1-week postischemic hippocampal CA1 neuronal loss in a gerbil global ischemia model involving brief (15-minute) bilateral carotid occlusion, but sustained dosing was required. These results document the anti-ischemic efficacy of a novel and potent inhibitor of iron-catalyzed lipid peroxidation and further support a key role of oxygen radicals in postischemic brain damage.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":30663510,"openaccessinfo":{"externalids":{"MAG":"2397365972","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives: To identify predictive biomarkers of CIMAvaxEGF success in the treatment of Non-Small Cell Lung Cancer Patients. Methods: Data from a clinical trial evaluating the effect on survival time of CIMAvax-EGF versus best supportive care were analyzed retrospectively following the causal inference approach. Pre-treatment potential predictive biomarkers included basal serum EGF concentration, peripheral blood parameters and immunosenescence biomarkers (The proportion of CD8 + CD28- T cells, CD4+ and CD8+ T cells, CD4 CD8 ratio and CD19+ B cells. The 33 patients with complete information were included. The predictive causal information (PCI) was calculated for all possible models. The model with a minimum number of predictors, but with high prediction accuracy (PCI>0.7) was selected. Good, rare and poor responder patients were identified using the predictive probability of treatment success. Results: The mean of PCI increased from 0.486, when only one predictor is considered, to 0.98 using the multivariate approach with all predictors. The model considering the proportion of CD4+ T cell, basal EGF concentration, NLR, Monocytes, and Neutrophils as predictors were selected (PCI>0.74). Patients predicted as good responders according to the pre-treatment biomarkers values treated with CIMAvax-EGF had a significant higher observed survival compared with the control group (p=0.03). No difference was observed for bad responders. Conclusions: Peripheral blood parameters and immunosenescence biomarkers together with basal EGF concentration in serum resulted in good predictors of the CIMAvax-EGF success in advanced NSCLC. The study illustrates the application of a new methodology, based on causal inference, to evaluate multivariate pre-treatment predictors","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":207933127,"openaccessinfo":{"externalids":{"MAG":"2988971017","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1911.05148"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Detection limit of PCR was investigated for Renibacterium salmoninarum, the causative agent of bacterial kidney disease, with a logarithmic growth phase. When genomic DNAs from serially diluted bacterial cells were subjected to PCR, the minimum concentration by PCR-detection with 30, 35 and 40 cycles of amplification were all 105 cells\/mL, and the sensitivity was not improved by treatments of the bacteria with lysozyme, achromopeptidase and\/or SDS. The extraction rate of genomic DNAs from the bacterial cells was approximately 3%. It was confirmed that PCR-detection limit for R. salmoninarum cells mixed with fish kidney tissues was significantly lower than that for the bacteria suspended in the medium. Moreover, there was no significant difference in the detection limit between immunofluorescence antibody technique (IFAT) and PCR. These results suggest that PCR detection should be followed by other methods such as IFAT.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":82115627,"openaccessinfo":{"externalids":{"MAG":"594297733","ACL":null,"DOI":"10.3147\/JSFP.43.29","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ObjectivesThe aim of this study was to evaluate the pork skin gelatin on rheological properties of myofibrillar protein gel as affected by different salt concentrations.Materials and MethodsMyofibrillar protein (MP) mixtures were prepared with or without 1.0% of gelatin powder at different salt concentrations (0.15, 0.30, 0.45 M). Gelatin powder was provided by Gel-Tech (Model #Gelatin-G, Busan, Korea). This gelatin powder had 209 bloom of jelly strength and 8 mesh of particle size. Cooking yield (%), gel strength (gf), shear stress (Pa), sodium dodecyl sulfate-poly acrylamide gel electrophoresis (SDS-PAGE), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (%T), sulfhydryl group (A415), and surface hydrophobicity (\u03bcg) were measured. The experimental design was 2-way (2x3) analysis of variance and each experiment were performed in triplicate (Table 1).ResultsThe addition of gelatin powder increased cooking yield and shear stress, and MP at salt concentration of 0.45 M had higher values of cooking yield and shear stress than the other lower salt concentrations (0.15, 0.30 M). Although gel strength was not affected by adding gelatin (p > 0.05), MP gel at the salt concentration of 0.45 M increased gel strength as compared to those at 0.15 and 0.30 M (p < 0.05). Protein bands of SDS-PAGE did not differ among the treatments, regardless of addition of gelatin. In microstructure, MP gels with increasing salt concentration showed compact and wet structures. The quantitative analysis of the changes in band at 1650 cm-1, 1624 cm-1, and 1680 cm-1 (\u0251-helix\/unordered structures and \u03b2 sheet) were decreased with increased salt concentrations. Increasing salt concentration showed low content of sulfhydryl groups. Myofibrillar protein mixtures with gelatin at 0.45 M was lower content of sulfhydryl groups than those without gelatin (p < 0.05). Surface hydrophobicity of MP at 0.45 M were higher than those of low salt concentrations (p < 0.05). At 0.15 M and 0.45 M, MP mixtures with gelatin was higher than those without gelatin (p < 0.05).ConclusionThese results suggested that MP gel at the salt concentration of 0.45 M was optimum condition for the application of the gelatin in MP systems.Table 1Experimental design of this studyIngredientsmg\/mlControlGelatin0.15 M0.30 M0.45 M0.15 M0.30 M0.45 MMyofibrillar protein40.040.040.040.040.040.0Buffer solution10.010.010.09.509.509.50Gelatin0.000.000.000.500.500.50Total50.050.050.050.050.050.0","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":198322274,"openaccessinfo":{"externalids":{"MAG":"2954768820","ACL":null,"DOI":"10.221751\/RMC2017.036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The theory that attention-deficit\/hyperactivity disorder (ADHD) stems from a deficit in an executive behavioral inhibition process has been little studied in adults, where the validity of ADHD is in debate. This study examined, in high-functioning young adults with persistent ADHD and a control group, 2 leading measures of inhibitory control: the antisaccad task and the negative priming task. ADHD adults showed weakened ability to effortfully stop a refle ve or anticipated oculomotor response but had normal ability to automatically suppress irrelevant information. Results suggest that an inhibitory deficit in ADHD is confined to effortful inhibition of motor response, that antisaccade and negative priming tasks index distinct inhibition systems, and that persistence of ADHD symptoms into adulthood is associated with persistence of executive motor inhibition deficits.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1222673,"openaccessinfo":{"externalids":{"MAG":"2072117113","ACL":null,"DOI":"10.1037\/0022-006X.70.1.153","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A fast, matrix-free implicit method has been developed to solve low Mach number flow problems on unstructured grids. The preconditioned compressible Euler and Navier-Stokes equations are integrated in time using a linearized implicit scheme. A newly developed fast, matrix-free implicit method, GMRES + LU\u2212SGS, is then applied to solve the resultant system of linear equations. A variety of computations has been made for a wide range of flow conditions, for both in viscid and viscous flows, in both 2D and 3D to validate the developed method and to evaluate the effectiveness of the GMRES + LU\u2212SGS method. The numerical results obtained indicate that the use of the GMRES + LU\u2212SGS method leads to a significant increase in performance over the LU\u2212SGS method, while maintaining memory requirements similar to its explicit counterpart. An overall speedup factor from one to more than two order of magnitude for all test cases in comparison with the explicit method is demonstrated.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":120581446,"openaccessinfo":{"externalids":{"MAG":"2041980757","ACL":null,"DOI":"10.1080\/10618560008940720","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this work, we discuss the results of investigation of potential distribution instabilities in undoped AlGaN\/GaN HEMTs and SiC transistor (FET) structures due to charge changes on the structure surface. An analysis of the state effects influence in the top layer of a passivated silicon nitride film reveals the possibility of the \"memory effect\" appearance due to electrons tunneling from an active area to different states in the silicon nitride film and AlGaN layer. All considerations are followed by device characterization. A technological process for silicon nitride film deposition and a precision method of hydrogen bond concentration measurement by FTIR were developed to carry out experiments with a high accuracy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":7057826,"openaccessinfo":{"externalids":{"MAG":"2538848181","ACL":null,"DOI":"10.1109\/ICSICT.2004.1435299","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Polyarylacetylene (PAA) resin is one among the ideal ablation materials, due to its high char yield and has been used to fabricate composite structures for solid rockets and missiles. However, the manufacturing quality of PAA composite is difficult to control. This article aims to reveal the formation mechanism of crack defect for PAA composite and presents an improvement method by resin modification. In this article, crack features and formation process of quartz fiber reinforced PAA composite were first studied, and the shrinkage and brittleness of PAA resin were evaluated to analyze the reason for crack formation. Furthermore, PAA resin modified by blending with phenolic resin was developed to reduce the crack defect. It is found that large curing shrinkage and extreme brittleness are the main reasons, which result in crack defect and poor mechanical performances of PAA. Moreover, PAA and phenolic (PF) blend was proved to be effective in raising ductility and reducing shrinkage, leading to the reductio...","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":136844629,"openaccessinfo":{"externalids":{"MAG":"2071153356","ACL":null,"DOI":"10.1177\/0021998310371539","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the last years, big data has become a useful paradigm for taking advantage of multiple sources to find relevant knowledge in real domains (such as the design of personalized marketing campaigns or helping to palliate the effects of several mortal diseases). Big data programming tools and methods have evolved over time from a MapReduce to a pipeline-based archetype. Concretely the use of pipelining schemes has become the most reliable way of processing and analysing large amounts of data. To this end, this work introduces bdpar, a new highly customizable pipeline-based framework (using the OOP paradigm provided by R6 package) able to execute multiple pre-processing tasks over heterogeneous data sources. Moreover, to increase the flexibility and performance, bdpar provides helpful features such as (i) the definition of a novel object-based pipe operator (%>|%), (ii) the ability to easily design and deploy new (and customized) input data parsers, tasks and pipelines, (iii) only-once execution which avoids the execution of previously processed information (instances) guaranteeing that only new both input data and pipelines are executed, (iv) the capability to perform serial or parallel operations according to the user needs, (v) the inclusion of a debugging mechanism which allows users to check the status of each instance (and find possible errors) throughout the process.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":236204518,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32614\/rj-2021-065","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32614\/rj-2021-065","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Seasonal variation in seagrass growth and senescence affects the provision of ecosystem services and restoration efforts, requiring seasonal monitoring. Remotely piloted aircraft systems (RPAS) enable frequent high-resolution surveys at full-meadow scales. However, the reproducibility of RPAS surveys is challenged by varying environmental conditions, which are common in temperate estuarine systems. We surveyed three eelgrass ( Zostera marina) meadows in Newfoundland, Canada, using an RPAS equipped with a three-color band (red, green, blue [RGB]) camera, to evaluate the seasonal reproducibility of RPAS surveys and assess the effects of flight altitude (30\u2013115\u00a0m) on classification accuracy. Habitat percent cover was estimated using supervised image classification and compared to corresponding estimates from snorkel quadrat surveys. Our results revealed inconsistent misclassification due to environmental variability and low spectral separability between habitats. This rendered differentiating between model misclassification versus actual changes in seagrass cover infeasible. Conflicting estimates in seagrass and macroalgae percent cover compared to snorkel estimates could not be corrected by decreasing the RPAS altitude. Instead, higher altitude surveys may be worth the trade-off of lower image resolution to avoid environmental conditions shifting mid-survey. We conclude that RPAS surveys using RGB imagery alone may be insufficient to discriminate seasonal changes in estuarine subtidal vegetated habitats.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":257319431,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1139\/facets-2022-0149","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.facetsjournal.com\/doi\/pdf\/10.1139\/facets-2022-0149","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Three-dimensional hierarchical CuO nanostructures with uniform flower-like and urchin-like morphologies have been successfully prepared by a facile, cheap and environmentally friendly solvothermal method. The as-prepared flower-like CuO is constructed by nanopetals, which are composed of nanoparticles, and the urchin-like CuO with a hollow structure is composed of tightly arranged nanorods. As anode materials for lithium-ion batteries, the flower-like CuO material exhibits a high initial discharge capacitance (1457.2 mA h g\u22121 at 100 mA g\u22121), good rate capability and excellent cycling stability. The superior electrochemical performance is mainly attributed to the hierarchical structure and the nanosize of the nanoparticles composing the nanopetals, which benefit electron and Li ion transportation, and provide large electrode\u2013electrolyte contact area. The extra capacity of the samples may be due to the partial reversible formation and decomposition of the gel-like SEI film on the surface of the electrode and pseudocapacitance.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":93158171,"openaccessinfo":{"externalids":{"MAG":"1878291017","ACL":null,"DOI":"10.1039\/C5RA09657J","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traffic analysis and prediction is one of the core contents in the feasibility study of highway construction project [1]. It has the vital significance to the highway construction and road networks development. The traditional traffic volume prediction, as four steps prediction method [2] represented, have many uncertain factors to make the deviation between final forecast results and actual situation is larger, and unable to achieve the expected effect. This paper takes that reducing the errors of the indefinite factors influencing the results as a starting point, improves the standard BP neural network [3] to solve the problems appearing in training, and puts it into the traffic volume prediction model which applied in engineering instances. Forecasting results show that this method predicts accurately and efficiently, and achieves the purpose of reducing prediction errors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4778316,"openaccessinfo":{"externalids":{"MAG":"1680972336","ACL":null,"DOI":"10.1109\/ICNC.2011.6022142","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper aims at assessing the role of gender in solid waste management in the informal sector in the high density suburbs of Bulawayo, the second largest city in Zimbabwe. The quantitative approach used in data collection involved physical characterisation of waste for composition analysis and the measurement of amounts of waste generated in the informal sector. Questionnaire surveys were also used to gather data on waste management practices by gender. Interviews, focus group discussions and participant observations were employed for the collection of qualitative data. Results showed the dominance of women in trades such as food catering and vending, clothes retailing, basket making and textiles while men dominated in motor mechanics, carpentry, welding, tinsmith, spare parts and door and window frame making. Generally, more solid waste is generated in enterprises operated by men than those operated by women. There is generally poor management of waste in the home industries, however, there is a greater level of cleanliness in the enterprises run by women who engage in waste reduction practices such as waste picking and recycling. It is thus necessary to incorporate gender perspectives in all developmental efforts including solid waste management in the informal sector.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110267037,"openaccessinfo":{"externalids":{"MAG":"2188678337","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The extreme ultraviolet (EUV) phase retarder is an important optical element for polarization analysis and conversion of EUV synchrotron radiation. In this paper, a linearly chirped Mo\/Si multilayer mirror is used to design an EUV phase retarder. With increasing thickness variation of the chirped multilayer, the reflective phase retardation between s- and p-polarized light increases at first and then reaches its maximum value. When the bilayer number increases from 2 to 20, the maximum phase retardation for an EUV source with a photon energy of 90\u2005eV increases from 5.97\u00b0 to 245.10\u00b0 for a linearly chirped Mo\/Si multilayer with 14.7\u2005nm central thickness. In addition, the phase retardations of chirped mirrors at different photon energies (80\u2005eV, 85\u2005eV and 90\u2005eV) are also investigated and compared. Furthermore, the physical mechanism of reflective phase retardation improvement is also studied by investigating the field intensity distributions inside chirped mirrors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237399551,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1107\/S1600577521006913","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The development of animal husbandry in the northern region of the state of Veracruz, known as the Totonacapan, produced major environmental changes. The highlights of this development are the introduction of cattle in the sixteenth century and African grasses in the second half of the nineteenth century. Environmental changes rapidly ensued between the years of 1940 and 1970 when livestock operations were intensified. The analysis of three case studies allowed us to estimate the impact that livestock intensification initiatives had across the state and to identify elements that would allow for a sustainable model of cattle ranching in this region.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":73575441,"openaccessinfo":{"externalids":{"MAG":"1504091066","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multilayer interference mirrors play a pivotal role in spectroscopic diagnostic systems, which probe electron temperature and density during inertial confinement fusion processes. In this study, aperiodic Mo\/B 4 C multilayer mirrors of varied thicknesses were investigated for X-ray plasma diagnostics at the 9.67-keV W-L \uf062 line. The thickness distribution of the aperiodic multilayers was designed using the 1 st Bragg diffraction condition and then optimized through a simplex algorithm to realize a narrow bandwidth and consistent spectral response. To enhance spectral accuracy, further refinements were undertaken by matching the grazing incidence X-ray reflectivity data with actual structural parameters. X-ray reflectivity measurements from the SSRF synchrotron radiation facility on the optimized sample showed a reflectivity of 29.7% \u00b12.6%, flat-band range of 1.3 keV, and bandwidth of 1.7 keV, making it suitable for high-temperature plasma diagnostics. The study explored the potential of predicting the 9.67 keV reflectivity spectrum using the fitting data from the Grazing incidence X-ray reflectivity (GIXRR) curves at 8.05 keV. Additionally, the short-term thermal stability of an aperiodic multilayer was assessed using temperature-dependent in situ X-ray measurements. Shifts in the reflectivity spectrum during annealing were attributed to interdiffusion and interfacial relaxation. The research team recommends the aperiodic Mo\/B 4 C multilayer mirror for operations below 300 \u2103.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":263744679,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract BACKGROUND AND AIM: Infection with the protozoan parasite Toxoplasma gondii has a worldwide distribution. Congenital infection is the most important part of the disease burden due to Toxoplasma infection in humans. Early diagnosis of maternal infection helps to prevent severe complications of toxoplasmosis. In the present study, three PCR assays (conventional, nested & quantitative) were evaluated for diagnosis of recent toxoplasmosis based on detection of Toxoplasma B1 gene. MATERIAL AND METHODS: The present study was carried out on 150 pregnant females who were serologically negative for anti-Toxoplasma IgG and IgM antibodies. RESULTS: The results revealed that out of 12 true positive cases (by 2 out of the 3 PCR protocols), 8 cases were positive by cPCR, 11 cases were positive by nPCR and 12 cases were positive by qPCR. Accurate estimation of genomic Toxoplasma DNA in positive samples was achieved by qPCR. In general, PCR assays offer a sensitive alternative of serological methods for diagnosis of recent maternal toxoplasmosis. In addition, qPCR decreases the risk of contamination of PCR products being a closed tube method and helps in estimation of infection load. CONCLUSIONS: We recommend screening of high-risk pregnant women by qPCR for early diagnosis of toxoplasmosis and proper management.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":45793655,"openaccessinfo":{"externalids":{"MAG":"2127833799","ACL":null,"DOI":"10.3889\/mjms.1857-5773.2014.0425","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/www.mjms.mk\/MJMS_Guidelines.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract Selected tide water gage readings taken during hurricane Betsy, 1965, along the Mississippi River Delta and adjacent areas are graphically presented. The various processes involved in the change in tide water level associated with the passage of a hurricane are discussed. The data are divided into three main categories in order to show the storm surge response along the coast (Gulf Coast gages), on inland waterways (New Orleans area gages), and on an inland lake (Lake Pontchartrain gages). A discussion of surge elevation along the Mississippi River from the mouth upriver to New Orleans is also included. The topography of the City of New Orleans is described and the extent and probable cause of the flooding in the City are discussed. The storm surge elevations along the coast predicted by currently used methods are found to compare favorably with the actual readings during Betsy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":122212929,"openaccessinfo":{"externalids":{"MAG":"2184667639","ACL":null,"DOI":"10.1175\/1520-0493(1968)096<0118:SSOTMR>2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Peer-to-peer networking is gaining popularity as a architecture for sharing information goods and other computing resources. However, these networks suffer from a high level of free-riding, whereby some users consume network resources without providing any network resources. The high levels of free-riding observed by several recent studies have led some to suggest the imminent collapse of these communities as a viable information sharing mechanism. Our research develops analytic models to analyze the behavior of P2P networks in the presence of free-riding. In contrast to previous predictions, we find that P2P networks can operate effectively in the presence of significant free-riding. However, we also show that without external incentives, the level of free-riding in P2P networks is higher than socially optimal. Our research also explores the implications of these findings for entrepreneurs, network designers, and copyright holders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":17946825,"openaccessinfo":{"externalids":{"MAG":"2128225820","ACL":null,"DOI":"10.1109\/HICSS.2004.1265472","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Air rings, used today in film blowing systems, have been developed down the years through trial and error experiments. They represent the limiting factor concerning the efficiency of film blowing lines with respect to throughput and take-off speed. Numerical simulation of the cooling process in film blowing provides a tool for the design and optimization of future cooling systems. Individual process and geometric parameters can be changed interactively with the effects on flow and heat transfer processes being analysed and applied to similar situations. The knowledge acquired regarding the physical interactions in the cooling of blown film makes a targeted optimization possible. The purpose of this paper is to present the foundamentals for calculating turbulent air flows in blown film extrusion and, additionally, a model for complete FE-simulation of the flow and heat transfer processes. Furthermore, the achieved simulation results will be discussed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":138397200,"openaccessinfo":{"externalids":{"MAG":"2167189577","ACL":null,"DOI":"10.3139\/217.970038","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Polarization fluctuation spectroscopy (PFS) is similar to conventional photon correlation spectroscopy (PCS) but measures the fluctuations in different polarizations of scattered light to obtain shape information in addition to the size information available from the temporal variations. The sample must be such that it forms a suspension sufficiently dilute that no multiple scattering occurs but sufficiently dense that the scattered light should be Gaussian in nature. The PFS technique measures the cross-correlation coefficient of intensities scattered into two polarization states to recover the aspect ratio of the particles. In this paper, it is shown how determination of the complete temporal cross-correlation function enables independent measurement of the size and shape parameters of a mono-disperse sample. The robustness of the technique is demonstrated using experimental data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119751779,"openaccessinfo":{"externalids":{"MAG":"1974986117","ACL":null,"DOI":"10.1088\/0957-0233\/15\/5\/001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Since 1929 oceanography has received more widespread attention in Japan than in any other nation, and virtually all has been financed directly or indirectly by the Government. The number of vessels (95) utilized by the Japanese Hydrographic Department alone for whole or part-time surveys during this period probably exceeded those of all other nations combined. \n \nOpen ocean investigations were carried on almost entirely by the Navy or under Navy control. Vessels pressed into the service of the Hydrographic Department included, in audition to 12 naval ships, seven survey vessels of other central government agencies, 30 prefectural station vessels, and 46 commercial craft. Of the latter, 22 were coastal fishing craft, 22 were killer ships of the whaling fleet, and two were merchant ships.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":129713238,"openaccessinfo":{"externalids":{"MAG":"2024137776","ACL":null,"DOI":"10.1029\/TR027I004P00521","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As a basic course for cultivating innovative and applied foreign language talents in the new era, college English audio-visual courses are facing huge opportunities and challenges in the era of big data. The transformation of the teaching environment under the background of big data is mainly reflected in the role of teachers, the dissemination of the information age, and the improvement of students' self-learning ability. The role of students in teaching has been strengthened, and the education system has undergone certain changes. This paper analyzes the current teaching status of college English audio-visual courses. According to the actual situation, a feasible reform plan is proposed to reconstruct the teaching mode of college English audio-visual courses, to improve the teaching quality of college English audio-visual courses, and to promote the improvement of students' comprehensive ability of college English.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252028331,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2022\/5434346","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/mpe\/2022\/5434346.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract Gesture recognition has always been at a peak when it comes to computer vision and human-computer interaction (HCI). Hand gestures can be used for interaction with systems like managing UAVs, medical devices, videogames, etc. In this paper, the main focus is on handicapped people, who are physically unable to speak or listen. With the help of computer interaction, gestures will be recognized. As, the same gesture by another people differs, recognizing it is the main task. The Convolution Neural Network (CNN) is used, to the extraction of features and gesture recognition, RGB dynamic gesture recognition method is used, the average accuracy received is around 97.44%, which is higher comparatively. The dataset used is the original dataset of Indian Sign Language (ISL), for learning features and the gestures of the images. The method sets the feature concatenation layer of Canny Edge and RGB images in the CNN structure, to give better performance of gesture recognition. Keywords: Convolution Neural Network, Indian Sign Language, hand gesture recognition, Human-Computer Interaction.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":234140521,"openaccessinfo":{"externalids":{"MAG":"3122761417","ACL":null,"DOI":"10.37591\/JONS.V8I3.750","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The development of large software is always done by teams of people working together and struggling to produce quality software within their budget. Each person in these teams generally knows his job and wants to do it, without being bothered by other people. However, when people work towards a common goal they have to exchange data and create dependencies between each other regarding these data. If these people have to follow a process, cooperating and synchronizing with co-workers and trying to reach one's own goal becomes too difficult to manage. This may leads to frustration, lower productivity and reluctancy to follow the predefined process. This is why some support is needed to avoid common mistakes that occur when people exchange data. In this paper, a hybrid approach to support cooperation is presented. The originality of this approach is the ability to enforce general properties on cooperative interactions while using the semantic of applications to fit particular situations or requirements. This paper gives a brief idea about the general enforced properties on activity interactions. It describes in detail the semantic rules that control activity results, the impacts of the cooperation on these rules and how both of dimensions interact.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":16304480,"openaccessinfo":{"externalids":{"MAG":"1986055009","ACL":null,"DOI":"10.1142\/S0218194099000334","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Testing Grid models and their resource management components is a critical part of efficient Grid development. There are two ways to experimentally assess the performance of Grid models: benchmarking and using synthetic grid workloads. Workload generation for Grids has become more problematic than for independent supercomputers. It requires standardization of the activity of thousand simultaneous users that use a broad amount of different resources. In this paper, we address the problem of synthetic Grid workload generation, and propose strategies based on real production traces. Carefully reconstructed traces from real supercomputers can provide a very realistic job stream for simulation-based performance evaluation of Grid job scheduling algorithms. We consider two types of jobs that can be run in Grids, and therefore included into grid workloads: unitary jobs such as sequential and parallel (e.g., MPI) applications, and composite jobs (workflow applications) that represent executable patterns of process interactions, and describe the execution of a complex application built from individual application components.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":13998724,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Industrialization is vital to nation's economy because it serve as a vehicle for development. The world's ever increasing population and its progressive adoption of an industrial based lifestyle has inevitably led to an increased anthropogenic impact on the biosphere. Increasing urbanization and industrialization have thus resulted in a dramatic increase in the volume of wastewater. Global water pollution scenario suggests that nearly 1.5 billion people lack safe drinking water and at least 5 million deaths are attributed to waterborne diseases such as cholera, hepatitis every year. The major industries contributing to water pollution are \u2013 textile mills, electroplating industry, metal processing industry, pulp and paper mill and tannery industry. The effluent generated from such industries generally contains alkanes, haloalkanes, polymers, surfactants, aromatic dyes etc. These compounds are toxic and persistent in nature Therefore it becomes imperative to completely degrade these organic compounds. Major pollution in textile effluent is due to high suspended solids, chemical oxygen demand, heat, color, acidity and other non biodegradable substances. In order to tackle this menace of pollution problem, it is desirable to degrade the dye into non toxic form before its discharge into the main stream. The traditional treatment techniques applied in textile wastewaters, such as coagulation\/flocculation, membrane separation (ultrafiltratation, reverse osmosis) or elimination by activated carbon adsorption, only do a phase transfer of the pollutant, and biological treatment is also not a complete solution to the problem. So Advanced Oxidation Processes (AOP s), like Fenton and Photo-Fenton processes, could be a good option to treat and eliminate textile dyes. Advanced Oxidation Processes are the one that offers a highly reactive, non-specific oxidant namely hydroxyl radicals (HO), capable of destroying wide range of organic pollutants in water and wastewater. Fenton's reagent oxidation is a homogeneous catalytic oxidation process using a mixture of hydrogen peroxide and ferrous ions. The main advantage of the Fenton's reagent is its simplicity in usage. In an acidic environment if hydrogen peroxide is added to an aqueous system containing an organic substrate and ferrous ions, a complex redox reaction will occur. The work done has been presented in five chapters. After introducing the problem and its content in the first chapter, the study begins with the background history of AOP's in second chapter. Then literature review on Fenton and Photo Fenton decolourization of various dyes and textile effluents has been given in the third chapter. The fourth chapter discusses experimental materials and methods that have been employed. Results and their discussion for decolourization of model dye compound and real effluent has been presented in fifth chapter. In the present study, industrial effluents were collected from textile mill and its characterization was done by measuring pH, EC, total solids, TSS, TDS, COD, and Color etc. Decolourization studies of Malachite Green dye was carried out with Photo Fenton process in specially designed reaction vessel in the photo reactor equipped with UV tubes. Experiments were performed in both UV and solar light at optimized condition. The decolourization of dye and textile effluent has been investigated in terms of change in color by measuring absorbance and reduction in COD. Various process parameters like pH, concentration of oxidant, Fenton ratio, and initial pollutant concentration were varied and their effects have been analyzed. The objective was to determine the best treatment for reducing color and COD of these colored solutions. In the case of MG dye (25 ppm), Fenton ratio 3:1 and oxidant dose was optimized at 300:100 mg\/l at 2.0 pH. At optimized conditions 82% reduction in color is obtained. In case of textile wastewater pH optimized was 2.0, Fenton ratio of 3: colour, 61% reduction in TDS and 76% removal of COD in 4hrs. of exposure. In some technological cycles of dye industry, it is necessary only to remove the color completely, and sometimes it is necessary to purify water slightly to enable its re-use as cooling or technological water so these Fenton and Photo-Fenton processes can be used efficiently and cost effectively for color elimination and biodegradability improvement of dyes effluents in order to close water circulation in factories, which results not only in economic but above all ecological advantages.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":96659605,"openaccessinfo":{"externalids":{"MAG":"2183113051","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective The objective of this study was to evaluate contrastenhanced computed tomography findings related to obstructive shock due to ascending aortic dissection (AAD). Methods The computed tomography findings in 9 AAD patients with shock, 11 AAD patients without shock, and 18 control subjects were evaluated for (1) pericardial effusion, (2) diameter of the inferior vena cava, (3) periportal hypodensity, (4) retrograde reflux of contrast material, (5) aortic and visceral enhancement, and (6) other factors (peripancreatic edema, bowel thickening\/dilatation). Results Patients with shock showed the highest ratio of pericardial effusion, periportal hypodensity, and retrograde reflux of contrast material; largest inferior vena cava diameter; stronger aortic enhancement in both the arterial and portal phases; lowered splenic and pancreatic enhancement in the arterial phase; and stronger visceral (especially adrenal) enhancement, except for the renal medulla in the portal phase. Conclusions Computed tomography findings related to obstructive shock due to AAD reflected impaired diastolic filling, decreased cardiac output, and flow redistribution in visceral organs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23838982,"openaccessinfo":{"externalids":{"MAG":"2333134209","ACL":null,"DOI":"10.1097\/RCT.0b013e318245c079","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The idea that journalists make use of framing is widespread. However, systematic studies of the role of frame sponsors\u2014that is, nonmedia actors who advocate a certain frame package\u2014in influencing the patterns in frame package use by journalists are limited. Which characteristics make frame sponsors successful in frame building, and why? In this study, we propose a new way of understanding the relationship between journalists and frame sponsors, by studying to what extent high authority and having a strong stake in an issue are important predictors of frame coverage, and whether a bidirectional relationship between frame sponsors and journalists can be discerned in frame building. We examine the two court cases against Geert Wilders, leader of the Dutch Freedom Party (PVV), for alleged hate speech (2009\u20132020). Based on a content analysis of media input, such as statements, social media posts, and press releases (N = 220) of relevant frame sponsors as well as news stories about the court cases (N = 691), we demonstrate that there is a reciprocal relationship between frame sponsors and journalists in frame building. Frame sponsors influence journalists in the use of frame packages, but framing in news reports also stimulates frame sponsors to communicate similar frame packages in the future. Actors with high levels of authority and a strong stake in the issue are more successful in getting their preferred frame packages across. By acknowledging the bidirectional relationship and expanding knowledge on who benefits most from this relationship, this study advances literature on frame building.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":225500930,"openaccessinfo":{"externalids":{"MAG":"3048272966","ACL":null,"DOI":"10.1177\/1940161220942760","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1940161220942760","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"SUMMARY Dahl \"S\" rats become hypertensive wben fed > high salt (NaCl) diet but remain normotensive on a low NaCl diet. Dahl \"R\" rats are normotensive on either diet. For a given perfusion pressure, isolated \"S\" kidneys excrete 50% less sodium than \"R\" kidneys. Therefore, we searched for a sodium-retaining hormone in \"S\" rats. Kidneys were isolated without ischemia from normal rats and were continuously perfused at 125 mm Hg with blood from Dahl \"S\" and \"R\" rats, all on low NaCl diets. All kidney and adrenal tissue had been extirpated from the perfusing rats. During 15 minutes of perfusion, the isolated \"normal\" kidneys excreted a mean of 164 jtEq Na\/rain\/100 g during 26 perfusion experiments with blood from \"R\" rats. The \"normal\" kidneys excreted a mean of 84 j*Eq Na during 24 perfusions with blood from \"S\" rats. Thus, the normal kidneys excreted half as much sodium wben perfused with \"S\" blood compared with \"R\" blood (p < 0.02). Seemingly, a Na-retainlng humoral agent is present in the blood of \"S\" rats on a low Na diet, in the absence of renal and adrenal tissue. Moreover, in these normal kidneys, perfusion with \"S\" blood induced a 16% higher renal vascular resistance than perfusion with \"R\" blood (p < 0.01), indicating vasoconstricting agents in \"S\" blood. However, the Na-retaining humoral effect is definitely not dependent on the vasoconstriction. The Na-retaining humoral effect in \"S\" blood could lead to Na retention by \"S\" kidneys in vivo, which could partially account for the susceptibility of \"S\" rats to NaCl hypertension. Furthermore, both \"S\" and \"R\" perfusing rats were continuously expanded with two-thirds blood and one-third Ringer's solution at a rate of 5% of body weight per hour. This expansion induced the appearance of a natriuretic humoral agent in the blood of both \"S\" and \"R\" rats to an equal degree, so that after 45 minutes of expansion, the isolated kidneys had increased their Na excretion approximately twofold. Hypertension is readily induced in Dahl \"S\" rats by feeding them a high NaCl diet. However, this hypertension can be almost completely prevented by concomitant treatment with thiazide diuretics that act mainly on the kidney to facilitate sodium excretion. This result is in agreement with the hypothesis that a shift in the pressure nttriuresis curve, reducing Na excretion for a given arterial pressure, is partially responsible for the great sensitivity to NaCl hypertension in the \"S\" rat. The Naretaining hormone may contribute to this shift.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":750301,"openaccessinfo":{"externalids":{"MAG":"1996857185","ACL":null,"DOI":"10.1161\/01.HYP.1.3.316","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PRESENT-DAY aircraft electric power distribution systems are complex and are used to transmit considerable amounts of power. These systems are becoming more complex and are being operated at higher power levels as the number of electrically operated aircraft instruments, controls, and auxiliary equipment increases. Large military surveillance aircraft, carrying powerful radar and electronic countermeasure equipment, represent an extreme example of the large-scale use of electric power in aircraft.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":51650337,"openaccessinfo":{"externalids":{"MAG":"1966402601","ACL":null,"DOI":"10.1109\/TAI.1963.6371775","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report a case of spontaneous reversal in utero of hydrops fetalis caused by parvovirus B19 maternal-fetal infection. The route leading to fetal hydrops is not fully understood. Severe anemia with hypoxemia and viral fetal myocarditis have been incriminated. Then the main issue is fetal death or spontaneous abortion. Cases of spontaneous reversal of hydrops fetalis are unusual. Fetal regenerative anemia is a good prognostic factor and emphasizes the place of conservative management.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3299431,"openaccessinfo":{"externalids":{"MAG":"1966067387","ACL":null,"DOI":"10.1159\/000264432","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The objective of this work was to analyze coffee (Coffea arabica) genotypes resistant to the coffee leaf miner (Leucoptera coffeella) using microsatellite markers. Sixty-six loci were evaluated, of which 63 were obtained from the Brazilian Coffee Expressed Sequence Tag (EST) database. These loci were amplified in bulks of individuals from F5 progenies of 'Siriema' (C. arabica x C. racemosa) resistant and susceptible to the insect, in eight samples of C. racemosa, and in a F6 population of 'Siriema' with 91 individuals segregating for resistance to the leaf miner. Polymorphisms were verified for two simple sequence repeat (SSR) loci in bulks of the susceptible progenies. The two polymorphic alleles were present in around 70% of the susceptible genotypes in F5 and in approximately 90% of the susceptible individuals in F6. However, the polymorphic EST\u2011SSR markers among populations contrasting for resistance to leaf miner were not correlated to the evaluated characteristics. SSR markers show inter\u2011 and intraspecific polymorphism in C. arabica and C. racemosa.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85780936,"openaccessinfo":{"externalids":{"MAG":"2186017820","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The generalized forward-backward method was used to investigate the scattering characteristics from the sea surface with breaking waves, which gives a preliminary analysis of mechanism of sea spike phenomenon. The integral equation using impedance boundary condition was used for one-dimensional (1-D) PM surface. GFBM increasingly improved the computational efficiency and made it possible to calculate rapidly electromagnetic scattering from sea surface at low grazing angles. The results show that there are larger fluctuations of the scattering intensity with the effects of the breaking waves in HH polarization than that in VV polarization.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15562919,"openaccessinfo":{"externalids":{"MAG":"2580196772","ACL":null,"DOI":"10.1109\/ISAPE.2016.7833993","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Republic of Panama currently has 300 recorded species of Trichoptera distributed among 14 families. Herein we add 42 new country records for Panama, including one new family (Anomalopsychidae) and three new genera (Anomalopsychidae: Contulma; Hydroptilidae: Byrsopteryx and Cerasmatrichia). The newly recorded caddisfly taxa increase Panama's total known fauna to 342 species, distributed among 15 families and 50 genera. These results are part of an ongoing effort to characterize the caddisfly fauna of Panama, and to evaluate that country's major watersheds (cuencas).","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":87471605,"openaccessinfo":{"externalids":{"MAG":"2338474431","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A total of 418 patients with aluminium phosphide poisoning admitted during January 1981 to December 1987, were studied and analysed for various clinical parameters. A steady increase in the number of patients was seen during the last 7 yr. Maximum number belonged to the younger generation and nature of poisoning was suicidal in most of these patients. Dose of poison consumed varied, but most patients consumed two tablets (6 g). A wide range of symptoms and signs was seen, the commonest being gastrointestinal manifestations and shock. Cardiac arrhythmias and conduction disturbances were seen in 38.2 per cent patients. The overall mortality was 77.2 per cent. Indices of a bad prognosis included poor response to dopamine infusion and continuous increase in its dosage, chest infections, adult respiratory distress syndrome and disseminated intravascular coagulation. The complications noticed were pericarditis, congestive cardiac failure, acute gastrointestinal haemorrhage and acute respiratory arrest. Histopathology of various organs showed changes suggestive of cellular hypoxia but the mechanism of ECG changes and of the complications could not be elucidated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43633714,"openaccessinfo":{"externalids":{"MAG":"2270709669","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nTo explore the etiology of May-Thurner syndrome (MTS) with acute iliofemoral deep vein thrombosis (DVT) regarding imaging findings and clinical features.\n\n\nMETHODS\nWe retrospectively analyzed 57 patients with acute left iliofemoral DVT from 2015 to 2020. The diameter of left common iliac vein (LCIV) at the maximal compression site and its percent compression regarding the average diameter of the uncompressed iliac vein were recorded in central and distal portions of the LCIV according to the location in the quadrant of lumbar vertebral body. Compression was categorized into simple and bony MTS; Simple MTS as LCIV compressed by the right common iliac artery (RCIA) versus Bony MTS as LCIV by lower lumbar degenerative changes regardless of RCIA compression. Initial computed tomographic venography (CTV) regarding chronic change of LCIV such as fibrotic atrophy or cordlike obliteration, extent of thrombus, and lumbar degenerative changes were evaluated. Therapeutic effect after initial therapy was assessed in follow-up CTVs after 3-6\u00a0months.\n\n\nRESULTS\nAll patients showed LCIV compression with 19 simple MTS (mean age, 42.8 \u00b1 14.1\u00a0years [23-67\u00a0years]; 12 females; symptom for 4.4 \u00b1 5.5\u00a0days) and 38 bony MTS (mean age, 73.0 \u00b1 10.2\u00a0years [49-85\u00a0years]; 26 females; symptom for 5.5 \u00b1 4.8\u00a0days). There was significant difference in age (p < .001) and no significant difference in sex or symptom duration between two groups (p = .691 and 0.415, respectively). All simple MTS showed compression only in the central LCIV and half of bony MTS showed compression in both central and distal LCIV (p < .001). Among the lumbar degenerative changes, symmetric anterolateral osteophyte (p < .001) and asymmetric osteophyte (p < .001) were significantly associated with bony MTS, but not scoliosis (p = .799), compared to simple MTS. Although there was no significant difference in chronic change of LCIV, thrombosis extent, and therapeutic effect between two groups (p > .05), chronic change of LCIV showed significant difference between single and dual compression (23.7% vs. 57.9%, p = .024) and residual thrombus after initial therapy was occurred in 21.1% of single compression and 47.4% in dual compression with non-significant trend (p = .082).\n\n\nCONCLUSION\nBony MTS related to lumbar degenerative changes with acute iliofemoral DVT occurs in older patients, presenting more than one stenosis at LCIV, inducing more chronic change with possibly weaker therapeutic effect than simple MTS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250090388,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/17085381221111010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives To increase the frequency and quality of screening for the metabolic syndrome in people prescribed continuing antipsychotic medication. Design An audit-based, quality improvement programme (QIP) with customised feedback to participating mental health services after each audit, including benchmarked data on their relative and absolute performance against an evidence-based practice standard and the provision of bespoke change interventions. Setting Adult, assertive outreach, community psychiatric services in the UK. Participants 6 audits were conducted between 2006 and 2012. 21 mental health Trusts participated in the baseline audit in 2006, submitting data on screening for 1966 patients, while 32 Trusts participated in the 2012 audit, submitting data on 1591 patients. Results Over the 6\u2005years of the programme, there was a statistically significant increase in the proportion of patients for whom measures for all 4 aspects of the metabolic syndrome had been documented in the clinical records in the previous year, from just over 1 in 10 patients in 2006 to just over 1 in 3 by 2012. The proportion of patients with no evidence of any screening fell from almost \u00bd to 1 in 7 patients over the same period. Conclusions The findings suggest that audit-based QIPs can help improve clinical practice in relation to physical healthcare screening. Nevertheless, they also reveal that only a minority of community psychiatric patients prescribed antipsychotic medication is screened for the metabolic syndrome in accordance with best practice recommendations, and therefore potentially remediable causes of poor physical health remain undetected and untreated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1269016,"openaccessinfo":{"externalids":{"MAG":"2129607707","ACL":null,"DOI":"10.1136\/bmjopen-2015-007633","PubMedCentral":"4606440","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/5\/10\/e007633.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Knowledge of structure, composition and texture, the three fundamental attributes of sedimentary deposits, is necessary for a robust analysis and interpretation of depositional environment. In the absence of core information; borehole images, \"elemental-capture spectroscopy\" and NMR logs all contribute to understanding the structure, composition and grain-size attributes. Grain-size is considered the most important textural parameter because it reflects the processes and energy levels active at the time of deposition. Early studies show that depositional processes and environment can be inferred from size distributions of Krumbein (1934) and Sahu (1964). These inferences are based on deductions and experimental data and deliver acceptable accuracy, although Krumbein (1941) shows other textural (e.g. shape, roundness, roughness) and compositional information enhances certainty). Building on early work, we present a methodology and examples where NMR derived grain-size distributions are used to infer depositional environment. In contrast to spot-core analysis, NMR provides a continuous along hole profile of grain-size-distributions. This study is the first to utilize a continuous grain-size-distribution profile. The study was conducted blindfolded, without initial reference to core studies, to test the robustness of the methodology. By using statistical parameters from grain-size distributions that are characteristic of depositional environments, and applying Sahu (1964) linear-discrimination functions, depositional systems for two wells were inferred to be shallow marine-to-fluvial deltaic. Linear-discriminate analysis of geostatistical variables showed bimodal distributions of sediments dominated by fine-grain sands and silts. The studied sandstones were concluded to be mainly fine grained, moderately to poorly sorted, fine skewed, mesokurtic, leptokurtic occasionally platykurtic in nature. Our conclusion was \"shallow-marine deposition\" and was compared and confirmed with core-driven studies as \"shallow marine\". In summary, profiles of grain-size-distributions from NMR logs provide important information about changes in depositional energy level from which we infer depositional setting and reservoir quality. A precise depositional environment interpretation is crucial for optimal\/economical field development.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":128741882,"openaccessinfo":{"externalids":{"MAG":"1997070660","ACL":null,"DOI":"10.2523\/IPTC-17754-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effects of multiple scattering on larger precipitating hydrometers have an influence on measurements of the spaceborne W\u2010band (94 GHz) CloudSat radar. This study presents initial quantitative estimates of these effects in \"dry\" snow using radiative transfer calculations for appropriate snowfall models. It is shown that these effects become significant (i.e., greater than approximately 1 dB) when snowfall radar reflectivity factors are greater than about 10\u201315 dBZ. Reflectivity enhancement due to multiple scattering can reach 4\u20135 dB in heavier stratiform snowfalls. Multiple scattering effects counteract signal attenuation, so the observed CloudSat reflectivity factors in snowfall could be relatively close to the values that would be observed in the case of single scattering and the absence of attenuation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":54747594,"openaccessinfo":{"externalids":{"MAG":"2169389097","ACL":null,"DOI":"10.1029\/2009GL038704","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Due to the side effects of drugs, the development of nanoscale drug delivery systems has led to a significant improvement in medicinal therapies due to drug pharmacokinetics changes, decreased toxicity, and increased half-life of the drug. This study aimed to synthesize tamoxifen (TMX)-loaded L-lysine coated magnetic iron oxide nanoparticles as a nano-carrier to investigate its cytotoxic effects and anti-cancer properties against MCF-7 cancer cells. Methods: Magnetic Fe3O4 nanoparticles were synthesized and coated with L-lysine (F-Lys NPs). Then, TMX was loaded onto these NPs. The characteristics of synthesized nanoparticles (F-Lys-TMX NPs) were evaluated by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), differential scanning calorimetry (DSC), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA). The drug release was analyzed at pH 5.8 and pH 7.4. The MCF-7 cells were exposed to F-Lys-TMX NPs, F-Lys NPs, and TMX for 24, 48, and 72 hours. To evaluate the cytotoxic potential of designed nanoparticles, MTT and apoptosis assays, real-time PCR, and cell cycle analysis was carried out. Results: The F-Lys-TMX NPs had spherical morphology with a size ranging from 9 to 30 nm. By increasing the nanoparticles concentration and treatment time, more cell proliferation inhibition and apoptosis induction were observed in F-Lys-TMX NPs-treated cells compared to the TMX. The expression levels of ERBB2, cyclin D1, and cyclin E genes were down-regulated and expression levels of the caspase-3 and caspase-9 genes were up-regulated. Studies on the drug release revealed a slow and controlled pH-dependent release of the nanoparticles. Cell cycle analysis indicated that F-Lys-TMX NPs could arrest the cells at the G0\/G1 phase. Conclusion: The findings suggest that F-Lys-TMX NPs are more effective and have the potential for cell proliferation inhibition and apoptosis induction compared to the TMX. Hence, F-Lys-TMX NPs can be considered as an anti-cancer agent against MCF-7 breast cancer cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244817748,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.34172\/bi.2021.23337","PubMedCentral":"9376161","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bi.tbzmed.ac.ir\/PDF\/bi-12-301.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Detailed surveys of McCall Glacier in the Alaskan Arctic reveal changes from 1972 to 1993. The ice surface dropped everywhere, by amounts ranging from about 3 m in the highest cirques tq more than 42 m near the present terminus. The total volume loss was 3.5+ 0.2 x 10' m(, resulting in an average mass balance of 0.33 + 0.01 in a . l he terminus has retreated by about 285 m at a rale of 12_.5 ma \\ Results from photogrammetry for an earlier period, 1958-71, were I.16x 10'm3 and 0.13 ma for volume change and mass balance, respectively; the mean terminus retreat rate was then 5.7 m a . The changes have to be seen in the context of McCall Glacier's low mass-exchange rate; annual accumulation and ablation, averaged over the years 1969 72 were only +0.16 and 0.3 m a '. Cross-profiles in the ablation area, surveyed at intervals of a few years, show an increased drop rate since the late 1970s. 7 he volume-ehange data suggest a climate warming in the early 1970s. Enhanced thinning of the lower ablation region and accelerated terminus retreat seem to lag this climate change by not more than 10 years, This indicates a reaction time of McCall Glacier that is considerably shorter than its theoretic response time of about 50 70 years.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":127029780,"openaccessinfo":{"externalids":{"MAG":"187162572","ACL":null,"DOI":"10.3189\/S0260305500015871","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The question of the use of force and its relation to political power has resurfaced in an era of terror attacks and wars against terror. The liberal conceptualization of this relation is limited by the bipolar understanding of force as either legitimate or illegitimate. Turning to the history of the Irgun, a Jewish underground movement, and its struggle against the British Empire in 1947 Palestine, this article seeks to expand the understanding of force beyond the liberal paradigm. The article offers a new model for understanding the use of force by the liberal nation-state and distinguishes between four different modes of force: violence, legality, terror, and empire. Whereas the liberal paradigm is limited to a conception of force as either justified and, hence, just (legality), or unjustified and, hence, unjust (violence), one may think of two additional forms of force, which, at first, may seem paradoxical: the unjust but justified force of terror and the force of empire, which is just but not in need of justification. Rather than using these forms as stable categories, the article seeks to understand the ways in which the uses of force became destabilized in times of political contestation. The article concludes by pointing out the broader implications of this model for the political analysis of the liberal nation-state and its use of force.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":143478975,"openaccessinfo":{"externalids":{"MAG":"2020238448","ACL":null,"DOI":"10.2202\/1565-3404.1122","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract The article suggests ways of dealing with the intricate discourse on \u00bbJewish Diseases\u00ab from antiquity up to the present - both within and beyond anti-Semitism. Firstly, it presents a four-dimensional model that systemizes the different ways in which the sources talk about the subject. In employing this model the article develops images of Jews and Judaism constructed by them. Secondly, the article distinguishes between a \u00bbdocumenting\u00ab and a \u00bbdeconstructive\u00ab way in which the sources are used in the humanities. However, since sources dealing with \u00bbJewish Diseases\u00ab are always biased and based on subjective premises, the article pleads for investigating the latter. This even applies to the modern biomedical discourse, for instance on \u00bbgenetic Jewish Diseases\u00ab, which promotes the biologisation and essentialisation of what it means to be Jewish.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":195789942,"openaccessinfo":{"externalids":{"MAG":"2949613261","ACL":null,"DOI":"10.1515\/asch-2019-0002","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/edoc.unibas.ch\/71758\/1\/20191203174813_5de691cd06342.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This study was to compare the professionalism and self-esteem of dental hygiene students according to career awareness. The analysis result shows that department of aptitude, work showed how differences in professionalism and self-esteem. Self \u2013esteem was positive correlated with the amount of professionalism. Therefore, clarifying the professional occupational sense as a correct understanding of their own values \u200band dental hygienists have a clear objective consciousness , it is important to work on the curriculum. Students will require active support to correctly establish the professional values that through a systematic job search programs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220450098,"openaccessinfo":{"externalids":{"MAG":"2334224980","ACL":null,"DOI":"10.14257\/AJMAHS.2015.08.70","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The lymphatic vasculature has been widely described and explored for its key functions in fluid homeostasis and in the organization and modulation of the immune response. Besides transporting immune cells, lymphatic vessels play relevant roles in tumor growth and tumor cell dissemination. Cancer cells that have invaded into afferent lymphatics are propagated to tumor\u2010draining lymph nodes (LNs), which represent an important hub for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites. In recent years many studies have reported new mechanisms by which the lymphatic vasculature affects cancer progression, ranging from induction of lymphangiogenesis to metastatic niche preconditioning or immune modulation. In this review, we provide an up\u2010to\u2010date description of lymphatic organization and function in peripheral tissues and in LNs and the changes induced to this system by tumor growth and progression. We will specifically focus on the reported interactions that occur between tumor cells and lymphatic endothelial cells (LECs), as well as on interactions between immune cells and LECs, both in the tumor microenvironment and in tumor\u2010draining LNs. Moreover, the most recent prognostic and therapeutic implications of lymphatics in cancer will be reported and discussed in light of the new immune\u2010modulatory roles that have been ascribed to LECs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237423323,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/med.21855","PubMedCentral":"9291933","ArXiv":null},"license":"CCBYNC","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/med.21855","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract Red blood cell distribution width (RDW) is associated with several diseases. However, the diagnostic value of RDW and its related factors remain unclear in colorectal cancer (CRC). This single-center retrospective study evaluated 211 Chinese CRC patients and 103 healthy controls. The association of RDW with the clinical parameters of CRC, as well as its correlations with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were analyzed. The diagnostic value of RDW alone or combined with CEA and CA19-9 was evaluated using receiver operating characteristic curve analysis. A meta-analysis was also performed to combine our data with previously published data to enhance our findings. In the CRC patients, RDW was clearly elevated and was significantly associated with CRC tumor location, histological type, T status (but not N or M status), and clinical stage. However, RDW was not significantly correlated with CEA or CA19-9 levels. Using RDW to diagnose CRC provided a sensitivity of 53.1% and specificity of 77.7%. The diagnostic accuracy of RDW was enhanced by combining RDW with CEA and CA19-9 levels. We identified 5 previous studies with 633 CRC patients and 1050 controls, which were combined with our cases and controls. The meta-analysis revealed an overall sensitivity of 69%, specificity of 70%, and an area under the curve of 0.74. In CRC cases, RDW was associated with tumor location, histological type, T status, and clinical stage. Furthermore, RDW had a moderate value for diagnosing CRC and might be useful in this setting.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153313524,"openaccessinfo":{"externalids":{"MAG":"2946413092","ACL":null,"DOI":"10.1097\/MD.0000000000015560","PubMedCentral":"6531168","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The publication of this impressive volume comes as a fitting culmination of the efforts that were freely expended by the organizers of a memorable congress. Those nutritionists who did not attend the congress are enabled, if at a later date, to share in the mass of information which was discussed. Those who did attend, and who often had to make a choice between several interesting communications to be given simultaneously, are now enabled to read at leisure all those papers that they inevitably had to miss. As reading matter they are presented with nine full papers given in plenary session, forty-four papers given at eleven symposia on selected subjects, and the abstracts of about 400 original papers given at sessional meetings. The titles of the symposia illustrate the wide range of interests covered by the science of nutrition: Nutrition and Health, Nutrition and Early Growth, Dietary Factors in the Genesis of Cardiovascular Disease in Man, Nutrition in Developing Populations, Animal Production under Adverse Climatic Conditions, Nutritional and Functional Aspects of Trace Elements, Protein-Calorie Deficiency and its Amelioration, Absorption of Nutrients, Endocrine Function and Reproduction in Relation to Nutrition, and Balance Experiments and Isotopes in Nutritional Investigation. It is still too early to assess the relative importance of the advances reported in the numerous communications. Dam's findings on the effect of the carbohydrate component of the hamster's diet on gall-stone formation, however, certainly deserved the honour of selection for presentation at a plenary session. In a very different type of paper Ritchie Calder stressed the problem of the co-existence of 3,000 million people on the small planet, Earth, \" not only politically but nutritionally.\" He pointed to the hard fact that \"free demographic expansion is a freedom which is inconsistent with freedom from want.\" The editors and publishers of this book must be congratulated on its printing, format, and binding. It is a notorious fault of the publications of international congresses that they often vary in these particulars on each occasion, leaving the librarian with an assortment of bound and unbound books or pamphlets which vary greatly in size. Hopes may be expressed that the present excellent volume, which sets a new high standard in the reporting of nutrition congresses, may be taken as a pattern by the organizers of future congresses. T. MOORE.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73113781,"openaccessinfo":{"externalids":{"MAG":"2141043703","ACL":null,"DOI":"10.1136\/BMJ.1.5440.979-C","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: To gain greater insight into how nurses engage with the multidisciplinary team during the surgical safety checklist process. Participants and setting: Participants were a purposeful sample of eight operating room nurses. The study was conducted in the operating room department of a major tertiary teaching hospital in South Australia. Methods: Phase 1 employed participant observations while phase 2 employed semi-structured interviews. Findings: Participants supported the use of the surgical safety checklist and valued its role to enhance patient safety. Multidisciplinary team culture played a significant role in how the checklist was conducted and heavily influenced the level of nurse participation in the process. Observations indicated poor compliance with the nursing review section of the checklist. Conclusions: Multidisciplinary team engagement is important for effective communication during the process of utilising the surgical safety checklist to promote safe outcomes for patients. Nurses are more likely to actively participate in the checklist process if they feel their role is valued by other team members. The nurse-specific area of the checklist is an area for improvement as this tends to be overlooked and considered less important than other checklist items. Modifications in timing the checklist and nurse training may be beneficial to address non-compliance with the nurse area of the checklist.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221701430,"openaccessinfo":{"externalids":{"MAG":"3103101590","ACL":null,"DOI":"10.26550\/2209-1092.1066","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.journal.acorn.org.au\/cgi\/viewcontent.cgi?article=1066&context=jpn","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we report a top gate SWNT-FET with reduced hysteresis in the IV characteristics and extremely low 1\/f noise. We have also investigated the source of 1\/f noise in these devices and attributed the low noise property to low trap charges near the carbon nanotube substrate interface. The SWNT-FET devices reported here and shown schematically in Fig. 1(a), are fabricated on high resistivity Si substrate (rhoap10 KOmega) with a 500 nm thermal SiO2. Catalyst patterns are defined by UV photolithography with a 10 mum spacing and subsequent iron deposition and lift-off. Single-walled carbon nanotubes (SWNTs) are then synthesized by chemical vapor deposition (CVD) of methane on the substrate using iron catalyst.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":10245005,"openaccessinfo":{"externalids":{"MAG":"2157237364","ACL":null,"DOI":"10.1109\/DRC.2007.4373746","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although print\u2013based materials remain the main distance education mode of delivery, the Namibian College of Open Learning (NAMCOL) recognises the use of multimedia as an important tool to enhance access and strengthen operational systems. Multimedia resources such as video, audio, animations and online content are produced as complementary resources to the print-based materials. The College appoints tutors to provide support to learners through various methodologies including face-to-face and online support. This study aims to explore the experiences of the NAMCOL Southern region tutors regarding the use of multimedia when they conduct their tutorial duties at a distance and through face-toface interactions. The theories that underpin this study are; Michael Moore's (1990) theory of transactional distance, Charles Wedemeyer's (1981) theory of independent study and Hede's (2002) Integrated Model of Multimedia Effects on Learning. The study was informed by an interpretive paradigm and adopted a qualitative case study design. Five tuition centres were purposively selected based on the set criteria for this study. Methods of collecting data used included semi-structured interviews, document analysis and observations. Data analysis was done by way of providing detailed descriptions of the setting, participants, and activities. Data was categorised and coded into themes. The study finding revealed that NAMCOL tutors in Southern region do not use multimedia in their instruction due to some challenges such as lack of time, lack of ICT skills, and lack of awareness. Tutors, however, show willingness to integrate ICT in their tuition. There is a lack of collaboration between NAMCOL Learner Support and Material Development operations which results in resources produced not utilised by learners. The study recommends that NAMCOL should ensure that all operational units are integrated to facilitate successful implementation of eLearning at the College.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":150757089,"openaccessinfo":{"externalids":{"MAG":"2914188191","ACL":null,"DOI":"10.30918\/aerj.71.18.092","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/www.netjournals.org\/pdf\/AERJ\/2019\/1\/18-092.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The reasons of the insufficient use in practice of theories of the life cycles of organization is, in the opinion of authors, absence of the methods, by means of which company could by itself and validly analyze the regularities of its development. Author's methodical approach is offered in work to diagnostics stage of organizational development, within the framework of which is described criteria and empirical indicators of the estimation of temporary periods of companies functioning.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197416005,"openaccessinfo":{"externalids":{"MAG":"2222979016","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"According to the popularity of variant video streaming applications over the Internet, video stream quality assessment is essential for video service providers in order to measure quality of service for such applications. There are many packet level parameters such as packet loss and jitter which can affect video stream quality. Consequently, measurement of these factors can be used for quality assessment of video streams. The main goal of this paper is assess and estimate the end-user perception of video streams quality at the receiver end through passive measurement evaluation. In the proposed scheme the video stream quality is evaluated by combination of application aware and network level metrics such as motion intensity and packet loss effect. Metrics are extracted from video stream packets' content. The experimental evaluations show the efficiency of the proposed scheme to estimate the video stream quality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":14296439,"openaccessinfo":{"externalids":{"MAG":"2002896456","ACL":null,"DOI":"10.1109\/ICCSPA.2015.7081292","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of the present work was to study the differentiation of states of typical fluidization (single bubble, multiple bubble and slugging) in a gas-solid fluidized bed, using spectral analysis of pressure fluctuation time series. The effects of the method of measuring (differential and absolute) pressure fluctuations and the axial position of the probes in the fluidization column on the identification of each of the regimes studied were evaluated. Fast Fourier Transform (FFT) was the mathematic tool used to analysing the data of pressure fluctuations, which expresses the behavior of a time series in the frequency domain. Results indicated that the plenum chamber was a place for reliable measurement and that care should be taken in measurement in the dense phase. The method allowed fluid dynamic regimes to be differentiated by their dominant frequency characteristics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":98403711,"openaccessinfo":{"externalids":{"MAG":"2169613163","ACL":null,"DOI":"10.1590\/S0104-66322004000300014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:Eating disorders are traditionally thought of as a problem specific to women, but evidence suggests the disorders also occur in men. Identifying the problem and referring patients for treatment can be difficult. Understanding the nuances of these disorders and realizing the incidence in men is important, as it is often overlooked as a differential diagnosis.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":3442924,"openaccessinfo":{"externalids":{"MAG":"2514543848","ACL":null,"DOI":"10.1097\/01.NPR.0000490392.51227.a2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"tive decision-making. Ironically, those pregnancies that areofhighenoughrisk towarrant in-person consultations, where additional support couldoffer significant value, are those in which partners are not permitted. Before the pandemic, partners often reported feeling excluded, fearful of the uncertainty of pregnancy and labour and frustrated by perceived lack of support from healthcare professionals. This may subsequently negatively impact their relationship because of the inability to adequately support their partners. Their exclusion from the majority of antenatal care therefore, may not only negatively impact the psychological wellbeing of women, which may in turn result in suboptimal outcomes, but also negatively impact their future relationship. As such, we agree with Herron and Herron and support their notion that attempts should be made towards delivering individualised patientcentred care, both antenatally and intrapartum.&","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":227135516,"openaccessinfo":{"externalids":{"MAG":"3107367436","ACL":null,"DOI":"10.1111\/1471-0528.16572","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Though wetlands are vital for the proper functioning of terrestrial ecosystems and provisioning of a wide range of goods and services, their sustainability is being threatened by inappropriate human resource use practices due to our limited understanding of how these systems operate and lack of appropriately informed interventions. We attempt to address these limitations by using historical CORONA photographs of 1967, Landsat imagery of 1989, 1994 and 2001 and information from the literature to investigate the role of natural and human factors in influencing the direction of environmental change in the proximal reaches of Botswana's Okavango Delta. Results of this investigation point to fragmentation of natural habitats, localised degradation of areas close to perennial water supplies, significant increase in woody cover, significant decrease in open grassland, increase in scrub and shrubs, deterioration in the quality of grazing and depletion of specific woody species. With the direction of change pointing to persistent decrease in the environment's supporting potentials, there is urgent need to adopt intervention strategies potentially capable of enhancing sustainable utilisation of natural resources in this sub-region.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128476219,"openaccessinfo":{"externalids":{"MAG":"2036407740","ACL":null,"DOI":"10.1111\/J.1475-4959.2009.00339.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study presents baseline data on the effect of sildenafil citrate on some of the haematological and biochemical parameters in wistar rats with diabetes and wound formation. Forty two albino rats weighing between 139 and 225 g were separated at random into seven groups (A, B, C, D, E, F and G) of six rats per group. Type 1 diabetes mellitus was induced in groups A, B, C and D by a single intra-peritoneal injection of 130 mg\/kg Alloxan. Rats in group A were treated with orally dose of 50 mg\/kg sildenafil citrate for 21 days and rats in group B were administered 10 IU of insulin intramuscularly once and sildenafil citrate as in Group A. The rats in group C were treated with a single dose of 10 IU of insulin intramuscularly, and rats in group D with only distilled water. Groups E and F were normal rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. Group G were normal rats without wound treated with sildenafil citrate as in Group A. Blood samples were taken before (day 0) and after the administration of the sildenafil citrate on day 7, 14 and 21. The results of the study showed significant decreased in red blood cells count from 6.28 \u00b1 0.46 \u00d7 10 6 to 2.81 \u00b1 0.46 \u00d7 10 6 in diabetic rats during the 14 days of treatment with sildenafil citrate, however, there was an indication that continues treatment for up to 21 days reduced the blood glucose and increased the red blood cells count and this may be an indication that sildenafil citrate improves insulin mediated glucose pathways. Keywords: Diabetes, Haematological parameters, Rats, Red blood cells, Sildenafil citrate","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":90397617,"openaccessinfo":{"externalids":{"MAG":"2601572350","ACL":null,"DOI":"10.4314\/SOKJVS.V15I1.3","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With half of all school-based agricultural education teachers leaving the profession within their first six years, the need is greater than ever for post-secondary graduates to enter and stay in the profession. This study explored potential influencers on graduates' career decisions, focusing on identifying potential reasons they chose to not enter, leave, or stay in the profession. The target population was Montana State University Agricultural Education Teaching graduates who completed their degree program between May 2005 and May 2016 (N = 58). Respondents' post-graduation career paths fell into five pre-determined groups, which were then narrowed into three broader groups: never entered, leavers, and currently teaching. Similar to previous research, competitive salaries outside education, being recruited for another position, and an inadequate work-life balance emerged as the largest factors in respondents' decisions to not enter the profession. Somewhat contradictory, adequate work-life balance; stable contracts with a competitive salary; and positive student, school, and community connections emerged as top reasons to remain in the profession. Since the most common reasons for not entering\/leaving the profession revolved around careers outside of education, primarily the salaries of those positions, it is recommended that stakeholders explore alternative methods of providing supplemental funding for these salaried positions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":212803616,"openaccessinfo":{"externalids":{"MAG":"2994167421","ACL":null,"DOI":"10.5032\/jae.2019.02109","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jae-online.org\/attachments\/article\/2230\/60.2.8.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Swabs of crop contents of 635 broiler chickens were obtained from 9 Ontario and 12 Quebec processing plants and cultured for Salmonella to determine prevalence in broiler crops. Serotypes of positive cultures were determined to evaluate the serotype profile. The overall prevalence of contamination was low (4.3%). Prevalence was higher in broilers sampled in Quebec (5.8%) than in those sampled in Ontario (2.2%). In Quebec, there were differences in prevalence among the groups of broilers sampled at the various plants. These differences were believed to be attributable to differences in Salmonella prevalence among groups of flocks delivered to the plants due to the limited exposure of the chickens to the plant. The serotype profile of Salmonella isolated from the crops of broilers in this study was similar in several respects to profiles obtained from other surveys of Canadian broiler flocks using either environmental samples or cloacal swabs. Similarities included: predominance of Salmonella hadar and Salmonella heidelberg; several other common serotypes at a low prevalence; little Salmonella enteritidis isolated in other studies, and no S. enteritidis isolated in this study. Results of this field survey of Salmonella in crops of broilers are similar to those of Canadian studies of other internal and environmental sites of broilers. The similarity indicates that monitoring of Salmonella environments of flocks of live broiler chickens should define profiles of Salmonella contamination of the carcasses and would also aid in determination of Salmonella contamination status of broiler flocks. Such information would assist efforts to reduce Salmonella contamination in broiler chickens.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3657843,"openaccessinfo":{"externalids":{"MAG":"2025841069","ACL":null,"DOI":"10.1093\/PS\/77.10.1497","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Most organizations strive to obtain fast, interactive and insightful analytics in order to fundament the most effective and profitable decisions. They need to incorporate huge amounts of data in order to run analysis based on queries and reports with collaborative capabilities. The large variety of Business Intelligence solutions on the market makes it very difficult for organizations to select one and evaluate the impact of the selected solution to the organization. The need of a strategy to help organization chose the best solution for investment emerges. In the past, Business Intelligence (BI) market was dominated by closed source and commercial tools, but in the last years open source solutions developed everywhere. An Open Source Business Intelligence solution can be an option due to time-sensitive, sprawling requirements and tightening budgets. This paper presents a practical solution implemented in a suite of Open Source Business Intelligence products called Pentaho Business Analytics, which provides data integration, OLAP services, reporting, dashboarding, data mining and ETL capabilities. The study conducted in this paper suggests that the open source phenomenon could become a valid alternative to commercial platforms within the BI context.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":215948246,"openaccessinfo":{"externalids":{"MAG":"2994263391","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Ten children with trichotillomania (hair pulling) were systematically evaluated with structured psychiatric interviews and rating scales assessing anxiety, depression, life events, self-esteem, and family functioning. Six of the subjects met diagnostic criteria for overanxious disorder on the Diagnostic Interview for Children and Adolescents--Revised--Child or Adolescent Version and\/or Diagnostic Interview for Children and Adolescents--Revised--Parent Version. Two met the criteria for dysthymia, including one of the subjects with overanxious disorder. No children reported associated obsessions or compulsions. Only one subject experienced tension before hair pulling and relief associated with hair pulling. The DSM-III-R criteria for trichotillomania, which currently require an increasing sense of tension before hair pulling and gratification with hair pulling, may be overly restrictive and in need of redefinition. Additional research with increased sample size is necessary to define diagnostic criteria for trichotillomania and clarify its relationship with other psychiatric diagnoses.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":45029866,"openaccessinfo":{"externalids":{"MAG":"2046869585","ACL":null,"DOI":"10.1097\/00004583-199201000-00020","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study aims to identify and examine efforts to recover assets resulting from criminal acts of corruption through additional criminal payments of replacement money. This study uses a normative juridical approach, which is descriptive analysis. The data used is secondary data obtained through literature study, which is then analyzed qualitatively. The results of this study are efforts to recover assets resulting from criminal acts of corruption through additional criminal payments of replacement money based on the provisions of Article 18 paragraph (1) letter b of Act No. 31 of 1999 jo. Act No. 20 of 2001. The purpose of imposing additional penalties is to ensure that state financial losses caused by actions can be recovered to the state through the imposition of additional penalties for payment of compensation. The judge in deciding the amount of additional criminal payment of compensation to the defendant based on legal facts at trial that prove the amount of property obtained by the defendant from the crime of corruption.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":237678701,"openaccessinfo":{"externalids":{"MAG":"3183390917","ACL":null,"DOI":"10.30659\/LDJ.3.2.%P","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A letter written by a High School English teacher in Punjab, Pakistan and a conversation with one of his colleagues from Quetta, Pakistan clearly explain the immediate necessity for teachers to specifically address the topic of terrorism and its negative impact on our society. They conclude that education has the potential to combat terrorism, but that at the present time, there is limited attention to these topics in the classroom.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153500833,"openaccessinfo":{"externalids":{"MAG":"1593974740","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Valley City, North Dakota, has an average daily water use of 750,000 gallons, which is obtained from wells tapping pattly confined gravel deposits in the Sheyenne River valley. These deposits at Valley City have a maximum thickness of more than 50 feet and an areal extent of approximately 1 square mile. The aquifer has been artificially recharged successfully since 1932 by diversion of water from the Sheyenne River to an abandoned gravel pit. During this time the piezometric surface in the aquifer has been raised more than 22 feet. \n \n \n \nPrior to 1958, the recharge system was operated from January until June; however, when the piezometric surface rose to within about 8 feet of the surface, the recharge operation was discontinued. Between June and January the piezometric surface declined as ground water was withdrawn. During the recharge-discharge cycle, the average annual fluctuation of the piezometric surface was 10 feet, amounting to a change in storage of about 1,000 acre-feet of water. Since 1958, the recharge system has been operated throughout the year. There has been a gradual improvement in the quality of the water in the aquifer since the installation of the recharge system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128746565,"openaccessinfo":{"externalids":{"MAG":"1998161355","ACL":null,"DOI":"10.1111\/J.1745-6584.1967.TB01245.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"March 2021, a 12-month-old infant was brought to the HPS East Zone Little Jonh, in the capital of the State of Amazonas, Brazil, where she was admitted with fever, vomiting, intense prostration, little acceptance of breast milk, difficulty in walking, associated with left-facing strabismus and neck stiffness. At admission, the main author performed a lumbar puncture, and serological tests on the CSF to identify the causative agent were referred to a reference laboratory, which suggested that they be referred to the Central Laboratory - LACEN for suspecting the presence of agent Angionsytrongylis Canyonensis. Although, the identification of the causative agent is difficult to be detected and confirmed, this case report shows us the importance of the clinical laboratory in the identification of Eosinophilic Meningitis. The sub-detection of eosinophils in the CSF helps to underestimate the prevalence of eosinophilic meningitis. Thus, CSF analysis, slide preparation, sediment staining, as well as knowledge about the importance of adequate leukocyte differentiation in CSF are extremely important, to properly conduct the final diagnosis of the disease and prevent possible endemicity. The knowledge of this condition and early detection allows an effective therapy and improvement of public health actions. ? ?,","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":236314234,"openaccessinfo":{"externalids":{"MAG":"3167766028","ACL":null,"DOI":"10.47172\/SFCDV2021-0002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nThe study aimed at evaluating the 2-year results obtained following combined surgical resective and regenerative treatment of advanced peri-implantitis defects comparing two methods of surface debridement\/decontamination (DD).\n\n\nMATERIAL & METHODS\nTwenty-four patients (n = 26 combined supra- and intrabony defects) completed the 24 months follow-up observation following access flap surgery, granulation tissue removal and implantoplasty at bucally and supracrestally exposed implant parts. The remaining aspects were randomly allocated to surface DD using either (i) an Er:YAG laser (ERL) device, or (ii) plastic curets + cotton pellets + sterile saline (CPS) were augmented with a natural bone mineral and covered with a collagen membrane.\n\n\nRESULTS\nAt 24 months, ERL treated sites failed to reveal significantly higher reductions in mean BOP (ERL: 75.0 \u00b1 32.6% versus CPS: 54.9 \u00b1 30.3%) and CAL values (ERL: 1.0 \u00b1 2.2 mm versus CPS: 1.2 \u00b1 2.2 mm) when compared with the CPS group. In both groups, mean CAL values were not significantly different when compared with baseline.\n\n\nCONCLUSION\nThe long-term stability of clinical outcomes obtained following combined surgical therapy of advanced peri-implantitis may be influenced by factors other than the method of surface debridement\/decontamination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205811767,"openaccessinfo":{"externalids":{"MAG":"1991899999","ACL":null,"DOI":"10.1111\/j.1600-051X.2012.01867.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this article we deal with the existence questions to the nonlinear biharmonic systems. Using theory of monotone operators, we show the existence of a unique weak solution to the weighted biharmonic systems. We also show the existence of a positive solution to weighted biharmonic systems in the unit ball in Rn , using Leray Schauder fixed point theorem. In this study we allow sign-changing weights.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":67841597,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. Widodo A, Lamid M, Effendi MH, Khailrullah AR, Kurniawan SC, Silaen OSM, Riwu KHP, Yustinasari LR, Afnani DA, Dameanti FNAEP, Ramandinianto SC. 2022. Antimicrobial resistance characteristics of multidrug resistance and extended spectrum beta-lactamase producing Escherichia coli from several dairy farms in Probolinggo, Indonesia. Biodiversitas 23: 215-221. Escherichia coli bacteria initially reside in the digestive tract of humans and animals but are able to adapt to new environments that are different from their initial habitat. The pathogenicity of E. coli can occur when these bacteria grow more than normal limits, produce toxins, and are resistant to certain types of antibiotics. The purpose of this study was to investigate the antimicrobial resistance characteristics of MDR and ESBL-producing E. coli from several dairy farms in the Probolinggo district of East Java province, Indonesia. A total of 150 samples consisting of 109 milk and 41 environmental samples from 41 dairy farms were used for isolation. TSIA and IMViC biochemical tests were used to identify E. coli bacteria. Escherichia coli resistance profile was obtained through disc diffusion test on several antibiotics, namely tetracycline, streptomycin, trimethoprim, chloramphenicol and aztreonam. Escherichia coli that was resistant to 3 or more antibiotics was defined as MDR. The results of isolation and identification obtained 124 (82.6%) isolates characterizing E. coli bacteria. The antimicrobial susceptibility test of E. coli showed 9 (7.26%) MDR isolates and 2 (22.22%) ESBL isolates by double-disc synergy test (DDST). MDR E. coli was dominated by the pattern of antimicrobial drug resistance TE-S-W (tetracycline, streptomycin, trimethoprim) with a total of 8 (38.10%) isolates, followed by antimicrobial drug resistance pattern TE-S-W-ATM (tetracycline, streptomycin, trimethoprim, aztreonam) with one (4.76%) E. coli isolates. The pattern of antimicrobial drugs of ESBL E. coli showed in one (11.11%) sample of ESBL E. coli from a milk sample with the pattern of TE-S-W-ATM (tetracycline, streptomycin, trimethoprim, aztreonam) and one (11.11%) sample ESBL E. coli (AL 30) from the environmental sample with a pattern of TE-S-W pattern (tetracycline, streptomycin, trimethoprim). The discovery of MDR E. coli isolates and ESBL E. coli from milk and environmental samples at several dairy farms in Probolinggo district, East Java, Indonesia is a matter of concern and requires real action to reduce antibiotic resistance.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":256964694,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.13057\/biodiv\/d240126","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/smujo.id\/biodiv\/article\/download\/12649\/6421","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The effect of model the Reading Concept Connection Discussion Evaluation (RCCDE) on critical thinking on water pollution material aims to determine the increase in critical thinking. Kind of research is a quasi experiment. Researchers in take samples using a purposive sampling technique with respondents in two classes. Data analysis using Anova. The total same of students is 22 in the experimental class using RCCDE and the control class using conventional methods. Based on the results of the analysis, it's can be concluded that there is an influence of the RCCDE model, on increasing critical thinking on Water Pollution material. Can be seen from the ANOVA test results obtained sig. 0,000 <0.05 (<0.050). Then, Ha is accepted. Based on these results, it be concluded that the use of the RCCDE model can improve critical thinking.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":234532232,"openaccessinfo":{"externalids":{"MAG":"3122791116","ACL":null,"DOI":"10.36835\/BIO.V8I1.664","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recent seroepidemiological studies and examinations of Ixodes ricinus ticks in Europe have demonstrated the presence of an emerging tick-borne infection with Rickettsia helvetica. We conducted a serosurvey in 168 Danish patients seropositive for borreliosis reflecting their exposure to I. ricinus ticks. A total of 21 patients (12.5%) had positive antibody titres to R. helvetica including 4 cases of seroconversion. None of the samples were positive for antibodies to Ehrlichia. We conclude that in humans exposed to I. ricinus ticks in Denmark the risk of acquiring rickettsial infection is for the first time demonstrated. In the same region of Denmark we collected 570 I. ricinus ticks from various sources, and examinations by PCR for Rickettsia were performed. Positive reactions were obtained in 23 ticks (4%), and R. helvetica was identified in all 13 of those for which sequencing was performed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25023241,"openaccessinfo":{"externalids":{"MAG":"1972427522","ACL":null,"DOI":"10.1080\/00365540410020776","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Non-human agency is an anthropocentrically problematic issue that some brave geographers have discussed with relation to plants in contexts such as orchards, cemeteries and gardens. I strive to shake the idea of agency loose of its deterministic human trappings, and explore plant agency from a more basic, bare-roots sense as something achievable by non-human actors. The context I have chosen for this endeavour is the hybrid space of the personal garden\u2014where botanical agency of presence, action, intent, association and capacity is experienced by gardeners actively involved in the space\u2014as portrayed in contemporary personal gardening literature.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":143249466,"openaccessinfo":{"externalids":{"MAG":"1776396635","ACL":null,"DOI":"10.3138\/TOPIA.21.63","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: The goal of this study was to describe bathing, toileting, and mouth care habits and preferences of older persons, as well as the importance of such habits. Design and Methods: Fifty-eight community-dwelling older persons were administered the Self-maintenance Habits And Preferences in Elderly questionnaire (SHAPE) during a one-on-one interview with a research assistant. Preferences were described by frequency distributions and mean importance for each item was calculated. Gender differences in preferences were examined using \u03c72 analyses, t tests were used to compare importance levels. Results: Women reported spending a longer time bathing, they were more likely to have privacy while bathing, to use a washcloth, a regular size towel, and less likely to use a large towel than were men. One-third of the women reported using some type of absorbent undergarment, while no men did so. Mouth care was the category that received the highest importance ratings. Although order of importance of items was similar across genders, women assigned higher levels of importance to these items than did men. Importance ratings given to atypical habits, such as unusually long or more than 1 bath\/day, were higher than those attributed to more usual habits. Implications: Knowledge of the range and importance of such self-care practices can provide information useful in the development of programs and for individualized care.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":13261894,"openaccessinfo":{"externalids":{"MAG":"2077101681","ACL":null,"DOI":"10.1159\/000088701","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Present study was conducted to evaluate different strategies for feed formulation in commercial broiler production. A total of 16 male newly hatched broiler chickens (Gallus gallus domesticus) were fed with different formulated diets in 3 feeding phases, starter (1\u201311 d), grower (12-22 d) and finisher (23\u201333 d). Four strategies of feed formulation (F1, F2, F3 and F4) were compared; where in F1 group was fed with traditional diet, F2 and F3 were fed with traditional diet after supplementation with 10% & 20 % paneer respectively. The last group (F4) was fed with traditional diet supplemented with 10% collagen and is incorporated into paneer to provide extra protein. The collagen used in the study was analyzed and characterized by UV-Vis spectroscopy, SDS-PAGE and FTIR which was confirmed type-I collagen. All the experimental birds had shown significantly high body weight (BW) for F4 birds compared with other groups. Feed conversion ratio was significantly lower for F3 birds compared to the birds in other groups. No differences were detected for feed intake and mortality. At 33 d, F4 birds (2.227) were significantly heavier than other groups and a remarkable difference was noticed in the decreasing order F3>F2>F1 (2.004 kg, 1.998 kg and 1.749 kg respectively). Notable differences were detected for carcass yield (%), breast yield (%) and breast-to-carcass ratio at 33 d. In conclusion, our results demonstrated that the enhancement in growth rate of birds was observed by providing them with collagen along with the regular diet.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204151822,"openaccessinfo":{"externalids":{"MAG":"2977201341","ACL":null,"DOI":"10.33640\/2405-609x.1158","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/kijoms.uokerbala.edu.iq\/cgi\/viewcontent.cgi?article=1158&context=home","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We investigate the critical exponents and associated with the singularities in the longitudinal and transverse structure factors of the one-dimensional antiferromagnetic Heisenberg model with nearest- (-) and next-nearest- (-) neighbour coupling of relative strength and an external field B with magnetization M(B).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118912795,"openaccessinfo":{"externalids":{"MAG":"2065670560","ACL":null,"DOI":"10.1088\/0953-8984\/9\/16\/015","PubMedCentral":null,"ArXiv":"cond-mat\/9902083"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/cond-mat\/9902083","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we consider the problem of reliable communication, the packet-loss prevention and packet-loss recreation recovery techniques are widely used and have many practical challenges. Hence, we propose a Reliable Adaptive Replication Routing (RARR) Algorithm, here the packet loss replication is accomplished in several hops and End-to-End (E2E) reliability is improved compared to conventional single E2E paths. RARR algorithm is comprised of a link capacity estimator, random disseminator and a replicator. The protocol employs an adaptive neighbor knowledge scheme which differentiates the density of nodes in the deployed scenario and hence reduces the overheads compared to the existing Proliferation Routing scheme. Simulation results demonstrate the effectiveness of this scheme and show that the proposed protocol is a feasible solution to increase the service quality (i.e., E2E transmission success rate, energy efficiency) compared with the well-known routing techniques. The proposed protocol is scalable and practical, and it dynamically adapts to the network topology.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":212475363,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This review examines Fordham's adaptation of his knowledge of the Joycean archive to the problem of explicating the Wake. Fordham follows a limited number of passages through an extended process of revision. In this genetic exegesis, a postmodern perspective determines the meaning and intention of Joyce's revisions. While Fordham's grasp of the minutiae of his subject is sophisticated and extensive, his study may appear one-sided in its emphasis on the deconstructive aspect of the Wake and its rejection of the book's cyclical and mythical thematics.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":143561585,"openaccessinfo":{"externalids":{"MAG":"2012064984","ACL":null,"DOI":"10.2979\/jml.2010.33.4.182","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In many high-resolution photographic and photoelectronic imaging systems, resolution is limited by image motion and vibration and, as a result, the high-resolution capability of the sensor may be wasted. In normal reconnaissance and robotics the sensor moves during the exposure. Some of the resulting image motion can be removed by mechanical compensation, but not all of it. The residual motion blurs the image, and usually this blur becomes the limiting factor for many high-quality imaging systems. The ever-increasing altitudes and coverage requirements of modern imaging have put a premium on high resolution. An application of this paper is the recovery of the original image by inverse filtering that depends on the modulation transfer function (MTF) of the real-time relative motion between the object and the imaging system. An original method developed here for numerically calculating MTF for any type of image motion is the basis of the paper.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109672635,"openaccessinfo":{"externalids":{"MAG":"2025077862","ACL":null,"DOI":"10.1117\/12.45718","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"As the volume of online short text documents grow tremendously on the Internet, it is much more urgent to solve the task of organizing the short texts well. However, the traditional feature selection methods cannot suitable for the short text. In this paper, we proposed a method to incorporate syntactic information for the short text. It emphasizes the feature which has more dependency relations with other words. The classifier SVM and machine learning environment Weka are involved in our experiments. The experiment results show that incorporate syntactic information in the short text, we can get more powerful features than traditional feature selection methods, such as DF, CHI. The precision of short text classification improved from 86.2% to 90.8%.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":56530736,"openaccessinfo":{"externalids":{"MAG":"1978239223","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMR.268-270.697","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The success of cranio-maxillofacial (CMF) surgery depends not only on surgical techniques, but also upon an accurate surgical plan. Unfortunately, traditional planning methods are often inadequate for planning complex cranio-maxillofacial deformities. To this end, we developed 3D computer-aided surgical simulation (CASS) technique. Using our CASS method, we are able to treat patients with significant asymmetries in a single operation which in the past was usually completed in two stages. The purpose of this article is to introduce our CASS method in evaluating craniofacial deformities and planning surgical correction. In addition, we discuss the problems associated with the traditional surgical planning methods. Finally, we discuss the strength and pitfalls of using three-dimensional measurements to evaluate craniofacial deformity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26746780,"openaccessinfo":{"externalids":{"MAG":"2136486464","ACL":null,"DOI":"10.1053\/J.SODO.2011.02.006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The yeast Saccharomyces cerevisiae grows at widely varying rates in different growth media. In order to maintain a relatively constant cell size, yeast cells must regulate the rate of progress through the cell cycle to match changes in growth rate, moving quickly through G1 in rich medium, and slowly in poor medium. We have examined connections between nutrients, and the expression and activity of Cln3\u2013Cdc28 kinase that regulates the G1\u2013S boundary of the cell cycle in yeast, a point referred to as Start. We find that Cln3 protein levels are highest in glucose and lower in poorer carbon sources. This regulation involves both transcriptional and post\u2010transcriptional control. Although the Ras\u2013cAMP pathway does not appear to affect CLN3 transcription, cAMP increases Cln3 protein levels and Cln3\u2013Cdc28 kinase activity. This regulation requires untranslated regions of the CLN3 message, and can be explained by changes in protein synthesis rates caused by cAMP. A model for CLN3 regulation and function is presented in which CLN3 regulates G1 length in response to nutrients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26143904,"openaccessinfo":{"externalids":{"MAG":"1976075923","ACL":null,"DOI":"10.1093\/emboj\/17.15.4370","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1170770?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Elective nodal irradiation (ENI) and involved field radiotherapy (IFRT) are definitive radiotherapeutic approaches used to treat patients with limited-disease small cell lung cancer (LD-SCLC). However, no solid consensus exists on their optimal target volume. The current study aimed to assess the clinical outcomes of patients with LD-SCLC who received definitive ENI or IFRT. A retrospective single-institution study of patients who received definitive radiotherapy between 2008 and 2020 was performed. All patients underwent whole-body positron emission tomography\/computed tomography before three-dimensional conformal radiotherapy. Among the 37 patients analyzed, 22 and 15 received ENI and IFRT, respectively. The thoracic radiotherapy dose was mostly either 60 Gy in 30 fractions delivered in 2-Gy fractions once daily or 45 Gy in 30 fractions delivered in 1.5-Gy fractions twice daily. The median follow-up period was 21.4 months. A total of 12 patients (32%) experienced locoregional relapse: 10 within and 2 outside the irradiation fields. One patient in the IFRT group experienced isolated nodal failure. Differences in locoregional relapse-free, progression-free, and overall survival rates between ENI and IFRT were not significant. Overall, IFRT did not promote a significant increase in locoregional recurrence compared to ENI. Our findings suggested the utility of IFRT in standard clinical practice and support its use for patients with LD-SCLC.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251539164,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18999\/nagjms.84.2.327","PubMedCentral":"9350561","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The promotion of electric energy production from solid biomass by the Austrian government has lead to a boom in the construction of new combined heat and power plants. The current total demand for wood chips in the research area for energy purposes is 70 400 m3 of loose volume chips per year. The expected increase in demand due to these new plants is more than 4 times greater than current demand: up to 302 700 m3 of loose volume per year. Even if the energy wood feedstock potential is satisfactory, the design of the supply chain is still unresolved. The aim of this study is to give decision-makers a base for further development. To accomplish this, we designed and tested four different supply scenarios: one for 9 plants and one for 16 plants. The scenarios were developed using a combination of geographic information systems (GIS) and linear programming methods. The results indicate that direct transport of solid fuel wood as round wood and chipping at the plant is the cheapest supply system with a resulting cost of 5.6\u20136.6 EUR\/m3 loose. Using harvesting residues can only be recommended for large plants because of poor fuel quality. In this case, residues would be chipped at or near the landing, piled and transported via self-loading trucks at a cost between 8.4 and 9.1 EUR\/m3 loose. In order to meet increasing demand and to ensure a continuous supply, especially during the winter and spring seasons it is necessary to optimize the supply chain by including storage terminals. However, using terminals and increased demand both lead to higher logistical costs. For example, if the total volume is handled via terminals, the average supply costs including storage will increase by 26%. Higher demand increases the costs by 24%.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54949380,"openaccessinfo":{"externalids":{"MAG":"2156309765","ACL":null,"DOI":"10.14214\/SF.464","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Previous studies in isolated limbs using crystalloid perfusion solutions have shown that control of the initial reperfusion reduces postischaemic complications. However, no experimental study has been undertaken to evaluate the concept of controlled limb reperfusion experimentally in an in vivo blood-perfused model and to assess the local as well as systemic effects of normal blood reperfusion and controlled limb reperfusion. Of 20 pigs undergoing preparation of the infrarenal aorta and iliac arteries, six were observed for 7.5 h and served as controls; 14 others underwent 6 h of complete infrarenal occlusion. Thereafter, embolectomy was simulated in eight pigs by removing the aortic clamp and establishing normal blood reperfusion at systemic pressure. In six other pigs, the composition of the reperfusate and the conditions of reperfusion were controlled during the first 30 min, followed by normal blood reperfusion. Some 6 h of infrarenal aortic occlusion leads to a severe decrease in high-energy phosphates and muscle temperature, together with a slight increase in creatine kinase and potassium in the systemic circulation. Normal blood reperfusion resulted in severe reperfusion injury: massive oedema developed, the tissue showed a marked decrease in oxygen consumption, glucose consumption. tissue ATP. total adenine nucleotides, muscle pH and total calcium in the femoral vein. Furthermore, a massive increase was seen in plasma creatine kinase concentration and potassium, together with the development of muscle rigidity. In sharp contrast, initial treatment of the ischaemic skeletal muscle by controlled limb reperfusion resulted in normal water content, oxygen consumption, glucose consumption, flow and muscle rigidity. Furthermore, controlled limb reperfusion resulted in higher total adenine nucleotides content. less tissue acidosis, markedly reduced creatine kinase release, and potassium release as compared with that of normal blood reperfusion. This study shows that 6 h of acute infrarenal aortic occlusion will result in severe reperfusion injury (postischaemic syndrome) if normal blood at systemic pressure is given in the initial reperfusion phase. In contrast, initial treatment of the ischaemic skeletal muscle by controlled limb reperfusion reduces the metabolic, functional and biochemical alterations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36556806,"openaccessinfo":{"externalids":{"MAG":"1840113422","ACL":null,"DOI":"10.1177\/096721099400200613","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intestinal bacteria have diverse and complex influence on their host. Evidence is accumulating that this may be mediated in part by bacterial extracellular membrane vesicles (MV), nanometer-sized particles important for intercellular communication. Little is known about the composition of MV from gram-positive beneficial bacteria nor how they interact with intestinal epithelial cells (IEC). Here we demonstrate that MV from Lacticaseibacillus rhamnosus JB-1 are endocytosed in a likely clathrin-dependent manner by both mouse and human IEC in vitro and by mouse IEC in vivo. We further show that JB-1 MV contain lipoteichoic acid (LTA) which activates Toll-like receptor 2 (TLR2) and induces immunoregulatory interleukin-10 expression by dendritic cells in an internalization-dependent manner. By contrast, neither LTA nor TLR2 appear to be required for JB-1 MV endocytosis by IEC. These results demonstrate a novel mechanism by which bacterial MV can influence host physiology and suggest one potential route for beneficial influence of certain bacteria and probiotics.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":234835202,"openaccessinfo":{"externalids":{"MAG":"3156260088","ACL":null,"DOI":"10.21203\/RS.3.RS-379923\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present study we have examined the provisions of Directive 2012\/13 \/ EU of the European Parliament and the Council on the right to information in criminal proceedings and a compared examination relating to the provisions of Romanian law regarding ensuring the right to information within the Romanian criminal proceedings. The innovations and the value of the work consist of the examination of the European legal instrument, the comparative examination and the critical opinions and the proposals of de lege ferenda. As recognized in the jurisprudence of the ECHR, the right to information of the person suspected or accused of committing a crime or arrested for committing a crime on the territory of another Member State is part of the right to a fair trial, being necessary its compliance throughout the criminal trial, on the territory of each Member State. At the same time the European legislative act establishes a general procedure that needs to be respected by each Member State, which entails theobligation for Member States to ensure at least the same rights as for the citizen or the conditions under which a national of another Member State is suspected, accused or arrested for the commission of a crime. This paper continues the research conducted in the field of International and European judicial cooperation in criminal matters, which have resulted in the publication of papers in wellknown publishing houses in the country and abroad, in national and international specialized journals or conference proceedings. The work can be useful to both theorists and practitioners in the field of judicial cooperation in criminal matters regarding the rights of certain categories of people and to the Romanian or European legislator for amending and supplementing the legislation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":157167809,"openaccessinfo":{"externalids":{"MAG":"2609601566","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The invention provides an adhesive composition and a film roll whereby blocking can be prevented and good temporary pressure bonding properties can be obtained. The adhesive composition of the present invention contains an epoxy resin, a latent curing agent, and an acrylic rubber having a carboxyl group or a glycidyl group, and the acrylic rubber phase-separates from the epoxy resin at normal temperature and is compatible with the epoxy resin at a predetermined temperature higher than normal temperature and lower than the curing temperature. Adhesive force is thereby reduced at normal temperature, blocking can be prevented from occurring, and good adhesive force can be obtained during temporary pressure bonding.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":139989308,"openaccessinfo":{"externalids":{"MAG":"2800382331","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a hybrid method that combines supervised learning and particle filtering to track the 2D pose of a human subject in monocular video sequences. Our approach, which we call a supervised particle filter method, consists of two steps: the training step and the tracking step. In the training step, we use a supervised learning method to train the regressors that take the silhouette descriptors as input and produce the 2D poses as output. In the tracking step, the output pose estimated from the regressors is combined with the particle filter to track the 2D pose in each video frame. Unlike the particle filter, our method does not require any manual initialization. We have tested our approach using the HumanEva video datasets and compared it with the standard particle filter and 2D pose estimation on individual frames. Our experimental results show that our approach can successfully track the pose over long video sequences and that it gives more accurate 2D human pose tracking than the particle filter and 2D pose estimation.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":15665246,"openaccessinfo":{"externalids":{"MAG":"2136784888","ACL":null,"DOI":"10.1109\/WACV.2011.5711527","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present study, the effects of laser surface melting (LSM) on chromium carbide of heat treated (AISI 304) austenitic stainless steels (ASS) was studied with the aim to suppress sensitization of 304SS. Austenitic stainless steels were heated (aging) up to (800) oC at constant holding time for two hours. LSM was conducted by using a (600 W) Yb-YAG laser. The microstructure was characterized by using optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). Results shows, refined and homogeneous microstructure which contains austenite (\u03b3) as basically phase and delta ferrite (\u03b4) as the secondary phase, however, chromium carbide (Cr23C6) phase are fully dissolved. Desensitization of heat treated ASS has been successfully achieved by LSM which reduced Cr depletion at the grain boundaries.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":164734022,"openaccessinfo":{"externalids":{"MAG":"2943895928","ACL":null,"DOI":"10.30684\/etj.36.3a.14","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.30684\/etj.36.3a.14","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a generalized variational method for calculation of equivalent-circuit parameters or scattering coefficients of any thin obstacle. The equivalent susceptance is obtained from an eigenvalue of a general-energy operator. The method is applied here to the scattering of a plane wave by a conducting screen containing a doubly-periodic array of square apertures. Previous variational formulations of analogous waveguide problems were largely restricted to cases in which only the dominant mode can propagate. In applying these methods to scattering problems, the ratio of aperture spacing to wavelength had to be restricted to less than unity at normal incidence so that no additional propagating modes were excited. The formulation presented here can be applied, however, for any number of propagating modes. Numerical results are presented for scattering by a periodically apertured screen, giving scattering coefficients as a function of wave number of the incident wave. The distribution of energy into higher-order diffraction lobes is evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":122809614,"openaccessinfo":{"externalids":{"MAG":"2143543340","ACL":null,"DOI":"10.1109\/TAP.1961.1145056","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work proposes hybrid multiuser detector based on Polynomial Expansion (PE-MuD) as a way to reduce computational complexity inherent to correlation matrix inversion, followed by the low complexity Local Search (LS) procedure, aiming to obtain a near-optimum multiuser Bit-ErrorRate (BER) performance, however with reduced computational complexity. The proposed hybrid PE-LS-MuD receiver topology is analyzed under realistic wireless mobile channels, as well as useful system operation scenarios. Simulation results indicate a suitable improvement in the performance-complexity trade-off regarding the classical linear multiuser detectors, particularly the MMSE. Keywords\u2014 Suboptimum Local Search Algorithms, Polynomial-Expanded Multiuser Detection, Gerschgorin Circles, DS-CDMA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209065090,"openaccessinfo":{"externalids":{"MAG":"2988223896","ACL":null,"DOI":"10.14209\/sbrt.2012.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/biblioteca.sbrt.org.br\/rails\/active_storage\/blobs\/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBWdz09IiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--b66d8ed1a0faf5d3fe592a1814558d3532726e13\/97605_1.pdf?disposition=attachment","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"An experimental model has been developed for perfusing intact canine prostates in vitro. The glands maintain normal anatomic and histologic appearance and function in a physiologic fashion. Estradiol has been shown to augment testosterone uptake by the prostatic cell. The implications of these findings are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20468002,"openaccessinfo":{"externalids":{"MAG":"2417320834","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Studies have shown that a large proportion of motorcycle accidents involve the failure of a road-user to see an approaching motorcycle. It is estimated that in Britain about one third of all collisions between motorcycles and other vehicles involve a visual or perceptual difficulty. Similar findings exist in other countries. The majority of such accidents occur in daylight but perceptual difficulties are also a prominent feature of night time collisions. This paper describes a series of trials designed to assess measures which might alleviate these problems by modifying the appearance of motorcycles. The use of existing and additional lighting and fluorescent materials, intended to assist the detectability and identification of motorcycles in traffic, was examined in both daylight and darkness. The results demonstrated ways of increasing the conspicuity of motorcycles in a wide range of daylight situations, but they also showed that some widely-used measures are not effective. At night, detectability was found to depend on the intensity and beam-pattern of the motorcycle's front lighting, but identification was aided by lighting used in addition to the standard headlamp.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":108554771,"openaccessinfo":{"externalids":{"MAG":"1602136804","ACL":null,"DOI":"10.4271\/900749","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Microwave Imaging Reflectometry (MIR) has been developed for unambiguous measurement of electron density fluctuations in fusion plasmas. The loss of phase information limiting the use of conventional reflectometry can be minimized by a large aperture imaging optics and an array of detectors in the MIR embodiment. The evaluation of the optical system is critical for precise reconstruction of the fluctuations. The optical systems of the prototype TEXTOR MIR [2] and newly-designed KSTAR MIR [5] systems have been tested with a corrugated target simulating density fluctuations at the cut-off surface. The reconstructed phase from the MIR system has been compared to the directly measured phase of corrugations taking into account the rotational speed of the target. The effects of optical aberrations and interference between lenses on the phase reconstruction have been investigated by the 2D amplitude measurement of the reflected waves and the diffraction-based optical simulations. (CODE V) A preliminary design of the KSTAR MIR optics has been suggested which can minimize the aberration and interference effects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250673187,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1748-0221\/7\/01\/C01077","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a method for optimizing the multi-turn injection efficiency for a medical synchrotron. We show that for a given injection energy, the injection efficiency can be greatly enhanced by choosing transverse tunes appropriately and by optimizing the injection bump and the number of turns required for beam injection. We verify our study by applying the method to the Korea Heavy Ion Medical Accelerator (KHIMA) synchrotron which is currently being built at the campus of Dongnam Institute of Radiological and Medical Sciences (DIRAMS) in Busan, Korea. First the frequency map analysis was performed with the help of the ELEGANT and the ACCSIM codes. The tunes that yielded good injection efficiency were then selected. With these tunes, the injection bump and the number of turns required for injection were then optimized by tracking a number of particles for up to one thousand turns after injection, beyond which no further beam loss occurred. Results for the optimization of the injection efficiency for proton ions are presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256343835,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3938\/jkps.69.927","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1606.04650","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Gene regulatory networks play a critical role in understanding cell states, gene expression, and biological processes. Here, we investigated the utility of transcription factors (TFs) and microRNAs (miRNAs) in creating a low-dimensional representation of cell states and predicting gene expression across 31 cancer types. We identified 28 clusters of miRNAs and 28 clusters of TFs, demonstrating that they can differentiate tissue of origin. Using a simple SVM classifier, we achieved an average accuracy of 92.8% in tissue classification. We also predicted the entire transcriptome using Tissue-Agnostic and Tissue-Aware models, with average R2 values of 0.45 and 0.70, respectively. Our Tissue-Aware model, using 56 selected features, showed comparable predictive power to the widely-used L1000 genes. However, the model's transportability was impacted by covariate shift, particularly inconsistent microRNA expression across datasets.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":258259500,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2023.04.17.537241","PubMedCentral":"10153180","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10153180","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"There has been an increasing concern on indoor air quality in recent years due to the possible harmful effects to human health. Indoor air pollution as a result of using natural gas for cooking and heating is a common health threat, particularly for women and young children. Therefore, quantification of the type and emission levels of these pollutants is necessary in order to mitigate and monitor the emissions. Computational fluid dynamics (CFDs) can be used to model airflow and dispersion within buildings of complex geometry and layout. In the present paper, a CFD analysis is performed to determine the concentration of indoor air quality for a typical one-floor building in order to determine the optimal locations of monitoring sensors. According to this study, placing the monitoring sensors based on the maximum concentrations of the individual contaminant does not entirely overcome the problems, as the concentrations of different hazardous pollutants cannot be added. Moreover, high concentration with low duration of exposure is not a good candidate for placing the monitoring system. A risk-based methodology is proposed to determine the optimal location for the monitoring systems. Different risk management strategies are also considered as a part of the methodology to reduce the exposure risk of indoor contaminants.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109850549,"openaccessinfo":{"externalids":{"MAG":"2006196541","ACL":null,"DOI":"10.1177\/1420326X11428164","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A guide to the Japanese artists whose signatures appear on the miniature Japanese medicine-cases called inro. The result of 35 years of study by the owner of the world's most comprehensive inro collections, this book contains 2704 entries with more than 2000 signature photographs gathered from private and public collections throughout the world. The text includes concise bibliographical details of the artists and a listing of the main publications and collections where their works are to be found. This publication is an essential guide to the understanding of one of the world's most important miniature art forms.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":190376810,"openaccessinfo":{"externalids":{"MAG":"575013429","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Environment monitoring is the foundation of environment plan and environment protection. It has huge works, complicate and extensive sources, and need a lot of investments to do, and is difficult to perform monitoring at 24 hours every day periodically. To resolve the problem, a architecture of the internet of things of environment monitoring based on cloud computing is proposed, and a creative model named as Unified Layered Model is proposed, which combines wireless sensor network, GPS, WiFi, 3G communication, database, cloud storage, cloud computing, data mining, and service computing mode, etc. The model aims at collect and management environment monitoring data and related data, provides in time, online or offline, parallel, distributed, cross time and space environment quality monitoring, feedback and control functions.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":110164440,"openaccessinfo":{"externalids":{"MAG":"2080747490","ACL":null,"DOI":"10.1049\/CP.2012.1320","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Identifying young children who need referral to a speech\/language pathologist is difficult because of possible communication problems. The limited time available to a pediatric nurse or nurse practitioner further complicates referral decisions. Early identification is advisable, yet unnecessary referrals can be costly, both in time and money. Recent research has indicated that some aspects of behavior may be particularly useful in making referrals. This article presents developmental milestones for infants' and toddlers' language comprehension, oral expression, gesture, and social interaction, which may be considered when estimating a child's need for further assessment. Questions frequently asked by parents concerning communication and resources for additional information are also presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37524907,"openaccessinfo":{"externalids":{"MAG":"2104039600","ACL":null,"DOI":"10.1067\/MPH.2002.115137","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chalcone and some other \u03b1,\u03b2-unsaturated ketones were subjected to transfer hydrogenation catalyzed by the dimer [Rh(cod)Cl]2 and the Wilkinson's catalyst in imidazolium-, ammonium- and phosphonium-based ionic liquids. In certain ionic liquids, the reduction of chalcone gave 1,3-diphenylpropan-1-one chemoselectively, in contrast with molecular solvents, which resulted in the formation of 1,3-diphenylpropan-1-ol. An accelerated reaction rate was observed in [emim][BuSO4] and [emin][HeSO4]. The observed chemoselectivity could be maintained applying a 5 molar equivalent excess of [bmim][BF4] to chalcone in 2-PrOH. This phenomenon suggests that there is an interaction between the chalcone carbonyl group and the ionic liquid which prevents reduction of the carbonyl group. The catalyst [Rh(cod)Cl]2 dissolved in an ionic liquid was successfully recycled at least three times, in contrast with Wilkinson's catalyst, which lost its activity on recycling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":98521899,"openaccessinfo":{"externalids":{"MAG":"2048458084","ACL":null,"DOI":"10.1039\/B913305D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background:The association between long-term air pollutants exposure with blood pressure and hypertension defined by 2017 American College of Cardiology (ACC)\/American Heart Association (AHA) Hypertension Guideline is still conflicting. This study was designed to investigate the associations between long-term exposure to air pollutants, blood pressure and hypertension defined by Chinese and ACC\/AHA guideline in Chinese adults. Methods: Our study was based on the baseline survey of the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei (CHCN-BTH) from 2017 to 2019. A spatial statistical model was used to assessed three-year (2014-2016) average pollutant concentrations for PM2.5, and other pollutants concentration (PM10, SO2, NO2) was assessed by data of air monitoring stations. Results: A total of 32,135 adults aged 18-80 years were included, each interquartile range (IQR) increment of PM2.5, PM10, SO2 and NO2 was associated with increases of 0.66mmHg (95%CI: 0.29, 1.03), 040mmHg (0.00, 0.81), 1.38mmHg (0.92, 1.84) and 0.54mmHg (0.16, 0.91) in SBP, respectively. SO2 was associated with increases 0.42mmHg (0.11, 0.72) in DBP. PM2.5, PM10, SO2 and NO2 was associated with an 14% (Odds ratio [OR]:1.14, 95%CI:1.06-1.23), 6% (1.06, 1.00-1.13), 9% (1.09, 1.02-1.17) and 8% (1.08, 1.01-1.16) increase of hypertension defined by Chinese guideline. PM2.5 and SO2 was associated with 16% (1.166, 1.093-1.245) and 10% (1.10, 1.03-1.18) increase of hypertension defined by ACC\/AHA guideline. Two-pollutants model, traffic-related pollution model and stratified analysis yielded similar results. Conclusions: We found that long-term exposure to PM2.5, NO2 and SO2 is associated with increase of blood pressure and hypertension defined by both Chinses and ACC\/AHA guideline. PM10 is associated with higher SBP and risk of hypertension defined by Chinese guideline.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":236625830,"openaccessinfo":{"externalids":{"MAG":"3162686955","ACL":null,"DOI":"10.21203\/RS.3.RS-455855\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To design and synthesize the hepatic targeting anticancer prodrug with norcantharidin (NCTD-Gal) conjugating structure, galactosylated NCTD derivatives were synthesized from NCTD analogues modified by a series of amino acids via acylation, hydrolysis, glycosylation and deacetylation. Seven new compounds were synthesized as beta-O-glycosides and characterized by IR, MS, NMR and element analysis. The compound 4a was chosen for the inchoate antitumor experiments on mice. The result showed that the antitumor inhibition rate of 4a groups with medium and high dose are clearly higher than that of NCTD group, which suggests that anticancer effect of NCTD is improved at a certain degree by galactosylation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38350061,"openaccessinfo":{"externalids":{"MAG":"2391503238","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper is an attempt to profile the personal and societal incentives for selective refusal among Israeli reserve soldiers during the Intifada. The article draws in part upon Kohlberg's model of moral development and addresses the following questions: (1) What is the motivation for selective refusal in times of morally-controversial conflicts such as the Intifada? (2) What socio-psychological incentives could ease the way to refusal? (3) What differentiates the individual objecting soldier from the objecting soldier who does not refuse to serve? The data for this theoretical discussion are taken from studies of 48 Israeli reserve soldiers out of 165 who decided to refuse military service within the first four years of the Intifada (Linn, 1995a, 1995b, 1995c) and of 36 out of 86 soldiers who refused during the war in Lebanon (Linn, 1989a). The findings suggest that unlike other objecting yet non-refusing soldiers, the selective refusers were motivated to change the unjust situation by assuming a position of disobedience to which they were personally predisposed and were capable of doing in their close milieu. Intifada and Lebanon refusers differed in their political affiliation and their different social support for their action.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":144084811,"openaccessinfo":{"externalids":{"MAG":"1999945866","ACL":null,"DOI":"10.1177\/0022343396033004004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The paper presents a prediction method for the naturally commutated induction machine drive. Analytical models of the major components of the drive scheme suitable for time-stepping simulation are developed. The adoption of a reference frame for the motor that rotates with the net flux vector enables a full account to be made for the magnetic nonlinearity in the motor's main flux path. Field-oriented d, q (FODQ) equivalent circuits for the induction machine are deduced. Both the capacitor bank and inverter models are expressed in this FODQ frame to produce compatible two-axis equivalent circuits, switching functions being evolved to represent the inverter tristate switch variables. Models for the DC link inductor and the rectifier, the latter also using switching function concepts, complete the drive system model. The system model is validated through comparison between calculated and test results obtained from an experimental rig.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":110694020,"openaccessinfo":{"externalids":{"MAG":"2150932822","ACL":null,"DOI":"10.1049\/IP-B.1993.0052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to determine the criteria and aspects of optimizing the role of zakat and infaq. This research's further objective is to build a model that can be used to determine criteria and priority aspects to become input for related parties to improve the role of zakat and waqf. This study combines descriptive qualitative and quantitative research using the Analytic Network Process (ANP) method. In building models and calculations, experts are involved in producing results following conditions in the field. This study indicates that zakat and waqf have played a role in encouraging national economic growth. Aspects that become alternatives in optimization are aspects of policy\/legality \/ institutional, technical aspects of operations\/databases, human resources\/management aspects, aspects of auditing\/control, socialization\/community literacy, and cooperation aspects. The criteria used in selecting alternatives are effective criteria (collection and distribution) and efficient criteria (cheap, fast, and applicable). The ANP model connects alternatives and criteria and calculates that the order of priority from the highest to the lowest is 1. Policy, Legality, and Institutions (47.28%); 2. Human Resources \/ Management Aspects (13.94%), 3. Socialization Aspects (12.66%); 4. Cooperation Aspects (12.54%); 5. Operational \/ Database Technical Aspects (8.27%) and; 6. Audit \/ Control Aspects (5.29%).","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":233469157,"openaccessinfo":{"externalids":{"MAG":"3127586274","ACL":null,"DOI":"10.23917\/JISEL.V4I1.13093","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a new approach to sensor based feature evaluation and selection for modelling purposes using a Self-Organizing Map. Self-Organizing Maps perform classification in a non-supervised fashion performing vector quantization and therefore place similar vectors close together in the two dimensional output space. The unsupervised process leads to the self organization of modelling with no previous knowledge of what is being modelled and therefore it does not model a predetermined environment. Taking the above into account feature selection was performed by analysing the contributions of different sensor based features, carrying large quantities of noise, towards tool wear classification. It was found that some of the features, not previously evaluated and justified, have a strong contribution towards tool wear classification. It is demonstrated that the use of the self-organizing map can be used to quantitatively evaluate the contribution of features towards neural network modelling of systems in the presence of noisy data. Keywords Feature selection, Self-organizing map, Condition monitoring, Tool wear.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":59133564,"openaccessinfo":{"externalids":{"MAG":"2223606863","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Japan's manufacturers are continually reminded that as global conditions change, they must be flexible enough to respond in a timely and decisive way. Constant updating of knowledge of overseas markets and opportunities is crucial. The more carefully Japanese manufacturers review their sources of competitive advantage, the greater their prospects of locking out competitors as global markets evolve. In part, the ability to influence competitive advantage requires a consideration of appropriate manufacturing location. Given the low costs and rising skill levels of workers in Asian developing countries, Japanese manufacturers face increasing pressure to relocate their operations outside Japan, a symptom of Japan's overall 'hollowing out' or de-industrialization. The de-industrialization is characterised by the displacement of Japan's exports by expatriate Japanese firms, rising imports that place increasing pressure on domestic manufacturers and domestic manufacturing job losses due to relocation or stiffer foreign competition. The resulting concern is that the de-industrialization may erode Japan's capacity for long-term economic growth (Cabinet Office 2002).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":203561532,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Investigates the role that retailers play in the cash funding of town centre management (TCM) schemes in the UK. The findings are drawn from a detailed questionnaire survey of town centre managers, and a series of interviews with retail business representatives. Reveals that although most TCM schemes attract some funding from retailers, the number who contribute is very low. Moreover, substantial financial involvement in TCM at a corporate level is restricted to seven major retail companies. It is also shown that retailers' financial support for TCM can be classified into two basic types: \"ring\u2010fenced\" and \"freestanding\". In conclusion, the implications of the relatively low level of retail funding for TCM are assessed, and some potentially useful areas of research are identified.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":167838372,"openaccessinfo":{"externalids":{"MAG":"2017248196","ACL":null,"DOI":"10.1108\/09590559910278614","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Concurrent duodenal and gallbladder perforation is a rare finding. Whilst cholecystoduodenal fistulas have been observed in literature, massive duodenal perforation with gallbladder erosion has not been recorded. We present the case of a 77-year-old female who was found to have a giant duodenal perforation (measuring 10cmx5cm) with an associated gallbladder perforation as well. On patient's first presentation, a Computed Tomography of the abdomen was performed due to abdominal pain and constipation. Images showed pneumoperitoneum and intra-abdominal free fluid. Upon performing an explorative laparotomy, findings of duodenal and gallbladder perforations were observed. Distal gastrectomy, cholecystectomy and gastrojejunostomy were performed. Due to uncertainty of the location of the ampulla to the ulcer edges, a cholangiogram catheter was advanced into the Ampulla of Vater via the Cystic Duct to definitively identify it prior to D1\/D2 stapling. Gastrograffin study was conducted on Day-5, showing good contrast flow. No major events occurred during her post operative recovery. The main concern is inadvertent stapling of D1\/D2 together with the ampulla. The passage of a catheter down the Cystic Duct, into the Common Bile Duct and through the ampulla is a definitive way to locate its position. In addition, Common Bile Duct patency with cholangiography can be ensured. Intra-operative improvisation such as advancing a cholangiogram catheter into the ampulla would assist surgeons in safely resecting proximal duodenum especially when it encroaches on the D1\/2 junction.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":261418646,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/bjs\/znad258.258","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/bjs\/article-pdf\/110\/Supplement_7\/znad258.258\/51295686\/znad258.258.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"2D-photonic crystal has the close packed hexagonal structure of metallized spheres. The selection rules are first necessary thing for understanding of interactions between differently polarized light and artificial photonic structure. This problem is the object of our paper. Known methods of group theory allow to solve such problems. However, the knowledge about symmetry of structure is the starting point of them. Usually the X-ray diffraction provides such information about natural 3D-crystals. Such assumptions so far have to do after the visual research of photonic structures in practice. Further these assumptions may be confirmed (or vice versa) by experimental research of optical response of photonic structures. We assumed that the symmetry of photonic structure is close to 2D (P6mm) group. Group-theoretical calculations were provided using the system of computer mathematics Maple. Both polarizations, normal to surface and parallel to that plane, were taken into consideration. The obtained selections rules were confirmed later by independent experiments.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55298785,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.12693\/aphyspola.132.1227","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.12693\/aphyspola.132.1227","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Large scale Digital Rights Management (DRM) systems are close to deployment in various areas. However, interoperability problems associated with DRM based content distribution systems encompassing many business models, consumer use cases, content and device types, have not been regarded in detail. On grounds of an analysis of these issues we argue that comprehensive DRM poses very special interoperability challenges, and advocate the utility of intermediary roles for viable DRM solutions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":5664393,"openaccessinfo":{"externalids":{"MAG":"1502976122","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The few observed data related snowmelt was the major cause of difficulty in extracting snowmelt factors such as snow cover area, snow depth and depletion curve. Remote sensing technology is very effective to observe a wide area. Although many researchers have used remote sensing for snow observation, there were a few discussions on the characteristics of spatial and temporal variation. Snow cover maps were derived from NOAA AVHRR images for the winter seasons from 1997 to 2006. Distributed snow depth was mapped by overlapping between snow cover maps and interpolated snowfall maps from 69 meteorological observation stations. Model parameters (Snow Cover Area: SCA, snow depth, Snow cover Depletion Curve: SDC) building for 5 major watersheds in South Korea. Especially SDC is important parameter of snowmelt model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":132129263,"openaccessinfo":{"externalids":{"MAG":"2512331948","ACL":null,"DOI":"10.11440\/RSSJ1981.23.119","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A transport system of a shipping company is composed of a set of different rotations that are served by its fleet of vessels. The transport market is volatile highly competitive forcing the companies to constantly adjust and improve their systems to better serve their markets. This thesis aims to find a solution method that can be useful for the planners of shipping companies when planning complex systems of rotations. In the first part several different solutions approaches are explored with out success. The final approach is based on set-partitioning and is in line with the procedures currently used by the planners of Eimskip and Containerships. The solution approach is considerably more work intensive then what was hoped to achieve but at the same time is likely to be beneficial for experienced planners. Using this method enables them to explore the effectiveness of their ideas, to make adjustments of the system and to find new rotations that will improve the quality of the over all system. The idea is based on designing a number of feasible rotations. Then using set-partitioning to select the best combination and time start dates for each rotation so that all constraints are met. The selected set of rotations is finally checked for capacities. At this point this method differs from most other solution approaches as the flow of containers is not directly considered except in the constraints of the set-partitioning model and then finally at the end of the process to verify its feasibility. This method requires considerable work to be done by the planer but at the same time is able to deliver solutions and gives feedback on possible improvements to the system. Acknowledgments\n When it was time to start thinking about a thesis project I was clear on only one thing. I wanted to tackle a real life project. With out the help of the people that work and live in the real world this would not be possible. I there for want to start by thanking the grate people at Eimskip PRO for their grate patients and understanding. Johann and Ingvar, thank you for answering my questions and giving my free access to your staff and your information systems. To the two Birgirs, Leo and Davi\u00f0 thanks for all the inside information and data. I met the same good will with the staff of Containerships. There Andris Velninis supplied my with all the data asked for and answered a wealth of questions. Thanks for that! The thesis is the final opportunity to learn while still supported by the professors and lectures of the university. Thanks for your help Allan Larsen and Michael Berliner Pedersen, and not the least for your patience with my some times hard to understand e-mails and formulations. The Glaucus team, Allan Olsen and Anders N. Nielsen deserves my gratitude for running my data all too many times and informing me on the workings of their interesting software, Glaucus. Last but not least I would like to thank Haraldur Gu\u00f0mundsson for proofreading the text and giving great comments on the setup of this thesis.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":107795861,"openaccessinfo":{"externalids":{"MAG":"16380844","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using classical endpoints, such as response rate and survival, as the sole measures of benefit, little progress has been made in the treatment of advanced pancreatic carcinoma in the past 30 years. We challenge the assumption that response rate and survival are the only appropriate endpoints for clinical trials in this disease setting. METHOD. A review of the literature and roundtable discussion were undertaken. RESULTS. Using current imaging techniques, it is inherently difficult to distinguish pancreatic tumor from normal pancreas, inflammatory tissue, local fibrosis, and unopacified bowel. As a result, objective tumor measurements are often imprecise, unreliable, and irreproducible. This difficulty may explain the wide variation in response rates reported in clinical trials even when the same therapies are used. Tumor\u2010related symptoms, such as anorexia, weight loss, severe pain (requiring opioid analgesia), and impaired functional status, are prevalent and debilitating characteristics of this disease. Tools that can assess these symptoms in a consistent fashion over time have been developed and have been integrated into clinical trials to evaluate new drugs in this setting. CONCLUSIONS. Systematic assessment of the impact of a new therapy on tumor\u2010related symptoms may provide a sensitive and accurate way to identify useful new treatments for patients with advanced pancreatic carcinoma. Such analyses can be a useful complement to the classical endpoints of response rate and survival. Cancer 1996;78:627\u201032.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221578982,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/(sici)1097-0142(19960801)78:3+<627::aid-cncr7>3.0.co;2-7","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Mexico, Cuba, the Philippines, and El Salvador. Closing the book, therefore, we wonder to what domain its findings apply. For a quick summary and comparison of Iran and Nicaragua, for thoughtful consideration of the implications of Theda Skocpol's analyses for contemporary revolutions, and for interesting reflections on the place of religion in those revolutions, Farhi's book serves well. For renewal of general ideas about revolutionary processes, please look elsewhere.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249338851,"openaccessinfo":{"externalids":{"MAG":"2129069692","ACL":null,"DOI":"10.1017\/S0020859000110983","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was conducted to investigate the causes of tree vigor weakening and occurrence of deformed fruit in problem of cultivation in 'Hongro' apple trees (Malus domestica). 'Hongro' apple, compared to 'Tsugaru' apple, had more flower buds including axillary flower buds. Therefore, the vigor weakening in 'Hongro' apple trees was due to extremely a lot of flowers and could be prevented with blossom thinning and N fertilizer by twice supply. Occurrence of deformed fruit was not different between terminal fruits and axillary fruits, but fruits set on lateral fruiting branch and weak vigor tree occurred a few deformed fruit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":82612060,"openaccessinfo":{"externalids":{"MAG":"843715650","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We explored the roles of angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7), and Mas activation in angiotensin II type 1 receptor blockade-mediated attenuation of vascular remodeling. Vascular injury was induced by polyethylene-cuff placement around the mouse femoral artery. After cuff placement, the mRNA level of both ACE2 and Mas was markedly decreased in wild-type mice, whereas ACE mRNA was not changed. Immunostaining of ACE2 and Mas was observed mainly in the media and was reduced in the injured artery. Administration of angiotensin-(1-7) decreased neointimal formation after cuff placement, whereas administration of [D-Ala(7)] angiotensin-(1-7), a Mas antagonist, increased it. Consistent with these results, we also demonstrated that neointimal formation induced by cuff placement was further increased in ACE2 knockout mice. In angiotensin II type 1a receptor knockout mice, mRNA expression and immunostaining of ACE2 and Mas in the injured artery were greater, with less neointimal formation than in wild-type mice. Increased ACE2 expression in the injured artery was also observed by treatment of wild-type mice with an angiotensin II type 1 receptor blocker, olmesartan. These results suggested that activation of the ACE2-angiotensin-(1-7)-Mas axis is at least partly involved in the beneficial effects of angiotensin II type 1 receptor blockade on vascular remodeling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1855754,"openaccessinfo":{"externalids":{"MAG":"2143918249","ACL":null,"DOI":"10.1161\/HYPERTENSIONAHA.112.191452","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conducted in Indonesia, this study analyzes how a religious group accused of being heretical ended up receiving threats and a number of violent reactions, a situation in which the victims were considered to have caused the violence. The study presented here focused on this case of the Ahmadiyya, a minority Muslim group in Indonesia that are the most frequently reported as being victims of violence. In total, 309 Sunni Muslims participated in filling out open-ended questions, and 10 Sunni Muslims (all male) participated in interviews discussing the Ahmadiyya and interreligious groups. We found that a substantial number of majority Sunni Muslims think that the values of the Ahmadiyya group are incompatible with common, mainstream Muslim values. As a consequence, their existence is considered a threat and a disruption to the Muslim community. Therefore, violence is justified if the group insists upon continuing their religious activities. In the eyes of these Sunni Muslims, Ahmadiyya members undermine the coherence within the Muslim community, and occurrence of violence against Ahmadiyya members is thus thought to be the victim's own fault.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":149464179,"openaccessinfo":{"externalids":{"MAG":"2800535282","ACL":null,"DOI":"10.1037\/rel0000186","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Research objective: This research aims to evaluate the potential of biologically purified water with added beneficial microorganisms for soil and plants for possible use in agriculture. In such a way that this type of water, which is not always accepted by growers, can instead be positively perceived by technicians in the sector and by those who often have no other water resources to irrigate their plants. Materials and Methods: The experiments, which began in April 2023, were conducted to the Abbey of S. Antimo in Piombino (LI) on different types of aromatic plants (rosemary, sage, mint, thyme). The experimental groups were: control; aqueduct water; aqueduct water with added microorganisms; recycled water; recycled water with added microorganisms. On 17 May 2023, plant height, number of leaves, vegetative weight, volume and length of roots, number of microorganisms in the substrate, number of dead plants and pH of the substrate were determined. Results and Discussion: The experiment showed that it is possible to use recycled water supplemented with microorganisms to significantly improve plant height, leaf number, and vegetative and root biomass, reducing plant mortality on aromatic species such as mint, rosemary, thyme and sage. In general, a significant increase in plant height and number of leaves as well as vegetative and root biomass was observed in plants treated with microorganisms The trial significantly showed how water inoculated with plant-stimulating microorganisms can significantly increase the vegetative and root biomass of various aromatic plant species. This aspect was also found in other horticultural species. Conclusions: The possible use of these waters in agriculture requires a careful study of the microbial communities present in them, which are often not suitable for plant growth. This experiment aimed to assess whether the use of plant-specific micro-organisms added to previously biologically treated water could improve the adaptation and growth performance of certain aromatic species. The results were significant and certainly deserve further studies on other horticultural species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259043756,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.30574\/gscarr.2023.15.2.0162","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/gsconlinepress.com\/journals\/gscarr\/sites\/default\/files\/GSCARR-2023-0162.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Objective: To explore the action mechanism of hsa_circ_0000231 in the occurrence and development of tongue squamous cell carcinoma (TSCC). Methods: Tissue samples of 60 TSCC patients were examined. The patients, including 32 males and 28 females, aged from 36 to 84 years old, underwent surgery in the Affiliated Hospital of Nantong University and Affiliated Tumor Hospital of Nantong University from December 2014 to December 2017. Saliva samples were obtained from healthy volunteers (5 males and 5 females, aged from 40 to 75 years old) and 10 TSCC patients. The TSCC cell lines (CAL-27, Tca-8113 and HN-4) were used. The expression levels of hsa_circ_0000231 in 60 pairs of freshly matched TSCC and para-carcinoma tissue samples, 10 pairs of saliva samples and 3 TSCC cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). hsa_circ_0000231 gene interference and lentiviral transfection were constructed, hsa_circ_0000231 in TSCC cell lines CAL-27 and Tca-8113 was knocked down, and the expressions of hsa_circ_0000231 in hsa_circ_0000231 interference group (sh-circ) and no-load lentivirus group (negative control) were tested with qRT-PCR. Cells with the highest knock-down efficiency were selected for CCK-8 test, colony formation assay, transwell invasion assay and scratch assay. The expressions of EMT-related proteins including E-cadherin, snail protein, N-cadherin and vimentin and proteins related to Wnt\/\u03b2-catenin signaling pathway including \u03b2-catenin, C-myc, Bcl-2, MMP-9 and Cyclin D1 were measured by western blot. After TSCC cells in the interference group were co-cultured with Wnt\/\u03b2-catenin pathway activator LiCl, the expressions of above proteins were re-measured by western blot. TSCC cells in interference group and control group were subcutaneously injected into nude mice to compare the effect of hsa_circ_0000231 knockdown on the growths of the tumors grafted subcutaneously in the nude mice. Statistical analysis software 25.0 was used for data analysis, and t-test or chi-square test was used for comparison between groups. Results: hsa_circ_0000231 was highly expressed in the tissue and saliva samples of TSCC patients and cell lines CAL-27, Tca-8113 and HN-4, but lowly expressed in paired para-carcinoma tissues, saliva samples of healthy people and normal human oral keratinocytes (all P<0.05). Log-rank univariate analysis showed that hsa_circ_0000231 expression level, tumor differentiation degree and T stage were related to the survival of TSCC patients (all P<0.05). Multivariate Cox risk regression model analysis suggested that hsa_circ_0000231 expression level (\u03c72=5.77,P=0.016) and T stage (\u03c72=5.27,P=0.029) were independent factors for the poor prognosis of TSCC patients. Western blot showed the expressions of snail protein, N-cadherin and vimentin were down-regulated, but E-cadherin was up-regulated in interference group compared with control group. In interference group, the expressions of \u03b2-catenin, C-myc, Bcl-2, MMP-9 and CyclinD1 were down-regulated, which were reversed after TSCC cells were co-cultured with LiCl. The knockdown of hsa_circ_0000231 reduced the proliferation, invasion and metastasis abilities of CAL-27 and Tca-8113 cells, which were reversed after TSCC cells were co-cultured with LiCl. The growth rate and volume of the tumors grafted subcutaneously in interference group using LiCl were greater than those in negative control group. Conclusion: hsa_circ_0000231 is an independent prognostic factor of TSCC. Highly expressed hsa_circ_0000231 can promote the proliferation, invasion and metastasis of TSCC cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253257916,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3760\/cma.j.cn115330-20211209-00790","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background and objectives. Tissue factor pathway inhibitor (TFPI) is a potent direct inhibitor of factor Xa and factor VIIa-tissue factor complex. In addition, TFPI was shown to be an inhibitor of angiogenesis and metastasis. Heparanase is an endo-beta-D-glucuronidase of 65 kDa that cleaves heparan sulfate chains on cell surfaces and in the extra-cellular matrix an activity that closely correlates with cell invasion, angiogenesis and tumor growth. The study hypothesis was that heparanase may reduce the level of TFPI or release it from the cell surface in an attempt to increase heparanase prometastatic potential. Material and methods. The effect of exogenous heparanase on TFPI expression and release to the medium was studied in HUVEC by immunoblotting, real time RT-PCR, and flow-cytometry. Human cell lines (MDA-MB-435 breast carcinoma; U87 glioma; HEK-293 embryonic kidney) were transfected to over express heparanase and the effect on TFPI was studied. TFPI expression was explored in heparanase transgenic mice by immunoblotting and immunostaining. Transfections with various modified forms of heparanase were used to further explore the effect of heparanase. Interaction between TFPI and heparanase was studied by co-immunoprecipitation analysis. Results. Heparanase was found to increase the release of TFPI to the medium, reduce the level of TFPI at the cell surface, and to up-regulate its expression in the cells. These results were verified in HUVEC, tumor cell lines, and in the animal model. The effect was independent of heparanase activity or interaction with heparan sulfate, and dependent on heparanase secretion. A protein co-interaction between TFPI and heparanase was found. Conclusions. Overall, a cell surface interaction is suggested in which heparanase impose increased release of TFPI from the cell surface to the medium, providing a local procoagulant and a systemic anticoagulant environment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90849113,"openaccessinfo":{"externalids":{"MAG":"2571132270","ACL":null,"DOI":"10.1182\/BLOOD.V106.11.4038.4038","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the transient synchronization dynamics of locally coupled phase oscillators moving on a one-dimensional lattice. Analysis of spatial phase correlation shows that mobility speeds up relaxation of spatial modes and leads to faster synchronization. We show that when mobility becomes sufficiently high, it does not allow spatial modes to form and the population of oscillators behaves like a mean-field system. Estimating the relaxation timescale of the longest spatial mode and comparing it with systems with long-range coupling, we reveal how mobility effectively extends the interaction range. \u00a9 2013 American Physical Society.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":15978967,"openaccessinfo":{"externalids":{"MAG":"2332930437","ACL":null,"DOI":"10.1103\/PHYSREVE.87.032911","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Renal cell carcinoma (RCC) is rare in children but is the most common renal tumor in adults. Pediatric RCC has different clinical characteristics, histopathology, and treatment compared with adult disease. Databases were reviewed from inception to February 2020, identifying 32 publications pertaining to 350 patients under 27 years. Surgery is the cornerstone for cure in localized RCC. Lymph node dissection remains controversial. Conventional radiotherapy has no curative role in RCC; similarly, conventional chemotherapy has not proven to be effective in large cohorts. Pediatric metastatic RCC has a poor outlook. There are no published prospective studies demonstrating which adjuvant therapy could improve outcome. Sunitinib, a tyrosine kinase inhibitor, is recommended in this group despite limited evidence. This review provides an overview for pediatric RCC, including the evolving role of precision medicine.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":221403910,"openaccessinfo":{"externalids":{"MAG":"3081890193","ACL":null,"DOI":"10.1002\/pbc.28675","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/discovery.ucl.ac.uk\/id\/eprint\/10113058\/12\/Supporting%20Info%20Figure%20S1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper summarizes the postnatal development of the visual system in a format that separates the various parts and functions into Input Components, Transmitting Components, Integrative Mechanisms, and Visually Induced Cognitive Behaviour. This treatment of a number of studies and philosophies that comprise the field of infants' vision indicates that most components and mechanisms are fully operative by the end of the second year of life.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33131291,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Histological study of operation material from 14 patients with forearm and hand injuries by a circular saw was performed, that made it possible to revise the insight into injury mechanisms, \u00abno-reflow\u00bb phenomenon, as well as to determine the histological correlates of artery traction and avulsion injuries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":74763502,"openaccessinfo":{"externalids":{"MAG":"2301177746","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Multidrug resistant MDR bacterial strains are causing fatal infections, such as mastitis. Thus, there is a need for the development of new target-oriented antimicrobials. Nanomaterials have many advantages over traditional antibiotics, including improved stability, controlled antibiotic release, targeted administration, enhanced bioavailability, and the use of antibiotic-loaded nanomaterials, such as the one herein reported for the first time, appear to be a promising strategy to combat antibiotic-resistant bacteria. The use of rationally designed metallic nanocomposites, rather than the use of single metallic nanoparticles (NPs), should further minimize the bacterial resistance. Aim: Green synthesis of a multimetallic\/ternary nanocomposite formed of silver (Ag), titanium dioxide (TiO2), and iron(III) oxide (Fe2O3), conjugated to chitosan (CS), in which the large spectrum fluoroquinolone antibiotic ciprofloxacin (CIP) has been encapsulated. Methods: The metallic nanoparticles (NPs) Ag NPs, TiO2 NPs, and Fe2O3 NPs were synthesized by reduction of Moringa concanensis leaf aqueous extract. The ternary junction was obtained by wet chemical impregnation technique. CIP was encapsulated into the ternary nanocomposite Ag\/TiO2\/Fe2O3, followed by chitosan (CS) conjugation using the ionic gelation method. The resulting CS-based nanoparticulate drug delivery system (NDDS), i.e., CIP-Ag\/TiO2\/Fe2O3\/CS, was characterized in vitro by gold standard physical techniques such as X-ray diffractometry (XRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared (FTIR) spectroscopy. Pharmacological analyses (i.e., LC, EE, ex-vivo drug release behavior) were also assessed. Further, biological studies were carried out both ex vivo (i.e., by disk diffusion method (DDM), fluorescence-activated single cell sorting (FACS), MTT assay) and in vivo (i.e., antibacterial activity in a rabbit model, colony-forming unit (CFU) on blood agar, histopathological analysis using H&E staining). Results: The encapsulation efficiency (EE) and the loading capacity (LC) of the NDDS were as high as 94% \u00b1 1.26 and 57% \u00b1 3.5, respectively. XRD analysis confirmed the crystalline nature of the prepared formulation. FESEM revealed nanorods with an average diameter of 50\u201370 \u00b1 12 nm. FTIR confirmed the Fe-O-Ti-CS linkages as well as the successful encapsulation of CIP into the NDDS. The zeta potential (ZP) of the NDDS was determined as 85.26 \u00b1 0.12 mV. The antimicrobial potential of the NDDS was elicited by prominent ZIs against MDR E. coli (33 \u00b1 1.40 mm) at the low MIC of 0.112 \u03bcg\/mL. Morphological alterations (e.g., deformed shape and structural damages) of MDR pathogens were clearly visible overtime by FESEM after treatment with the NDDS at MIC value, which led to the cytolysis ultimately. FACS analysis confirmed late apoptotic of the MDR E. coli (80.85%) after 6 h incubation of the NDDS at MIC (p < 0.05 compared to untreated MDR E. coli used as negative control). The highest drug release (89% \u00b1 0.57) was observed after 8 h using PBS medium at pH 7.4. The viability of bovine mammary gland epithelial cells (BMGE) treated with the NDDS remained superior to 90%, indicating a negligible cytotoxicity (p < 0.05). In the rabbit model, in which infection was caused by injecting MDR E. coli intraperitoneally (IP), no colonies were detected after 72 h of treatment. Importantly, the histopathological analysis showed no changes in the vital rabbit organs in the treated group compared to the untreated group. Conclusions: Taken together, the newly prepared CIP-Ag\/TiO2\/Fe2O3\/CS nanoformulation appears safe, biocompatible, and therapeutically active to fight MDR E. coli strains-causing mastitis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251685197,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/pharmaceutics14081719","PubMedCentral":"9412270","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1999-4923\/14\/8\/1719\/pdf?version=1661160405","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose: American Indian adults have not experienced decreases in colorectal cancer (CRC) incidence and mortality observed in other races or ethnic groups and their screening rates are low. Decision aids that explain available CRC screening options are one potential strategy to promote screening. The goal of this study was to test the effect of a culturally adapted decision aid on CRC-related outcomes among American Indian adults, including screening-related knowledge, attitudes, self-efficacy, intentions, and screening modality preferences. Methods: We recruited American Indian adults aged 50\u201375 years who were not current with CRC screening. Participants viewed a 9-min multimedia decision aid that used narrative vignettes to provide educational information about screening along with messages to address culturally specific barriers and values uncovered in formative research. We conducted a single-arm (pre\u2013post) study and assessed screening-related outcomes at baseline and immediately after viewing the decision aid. Results: Among n=104 participants, knowledge scores increased from a mean of 36% correct to 76% correct. Participants also had statistically significant increases in positive attitudes, perceived social norms, self-efficacy, and intent. The proportion of participants who identified a preference for a specific CRC screening modality rose from 81% identified at pre-intervention to 93% post-intervention (p=0.013). Conclusion: Our study provides promising new findings that our culturally adapted decision aid is efficacious in educating American Indian adults about CRC screening and increases their screening intentions and ability to state modality preferences. Future research is needed to test the decision aid as a component of CRC screening interventions with American Indian adults.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":215243874,"openaccessinfo":{"externalids":{"MAG":"3014919297","ACL":null,"DOI":"10.1089\/heq.2019.0095","PubMedCentral":"7133428","ArXiv":null},"license":"CCBY","url":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/heq.2019.0095","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The histological study of 36 cases of Non-Hodgkin Lymphomas beginning for the E.N.T. area has allowed us to show that the Non-Hodgkin Lymphoma Working Formulation made for the lymph nodes may be used to ENT Localization and give a reliable prognosis. Other elements like: sex, clinical staging, treatment have no significant value concerning the survival rate in our study. This study agrees with the previous studies about the predominance cases to the high power of malignancy of these lymphomas.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31415646,"openaccessinfo":{"externalids":{"MAG":"2435573955","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive or sporadic early adult-onset myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase (GNE) gene. Characteristic pathologic features of DMRV are rimmed vacuoles on muscle biopsy and tubulofilamentous inclusion in ultrastructural study. Presence of inflammation in DMRV is unusual. We report a sporadic case of DMRV in a 40-year-old Thai man who presented with slowly progressive distal muscle weakness. Gene analysis revealed a compound heterozygous mutation of the GNE gene including a novel mutation c.1057A>G (p.K353E) and a known mutation c.2086G>A (p.V696M). The latter is the most common mutation in Thai DMRV patients. The muscle pathology was compatible with DMRV except for focal inflammation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3467283,"openaccessinfo":{"externalids":{"MAG":"2150571717","ACL":null,"DOI":"10.1159\/000360730","PubMedCentral":"3975748","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1159\/000360730","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Ki-67\/MIB-1 is the most widely used immumohistochemical marker to measure cell proliferation in recent years, and its high expression is significantly related to high malignancy and short survival cycle. This meta-analysis was conducted to confirm the prognostic value of Ki-67\/MIB-1 in meningioma patients. A comprehensive search was carried out of mainstream electronic databases including Pubmed, EMBASE, Google Scholar, Web of Science, and Cochrane Library, and finally 10 studies containing 1,414 meningioma patients were included in the meta-analysis. The combined hazard ratio (HR) and its 95% confident intervals (CIs) were used to evaluate the association between Ki-67\/MIB-1 expression and survival. High expression of Ki-67\/MIB-1 was found to be significantly associated with low RFS (HR 3.31, 95% CI 1.62-6.78, P = 0.001, random effect) and PFS(HR 3.14, 95% CI 1.64-6.00, P = 0.001, fixed effect). Subgroup analysis was conducted to explore the potential heterogeneity. Results of the meta-analysis indicated that high expression of Ki-67\/MIB-1 may serve as a useful biomarker for poor prognosis in meningioma patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":91961191,"openaccessinfo":{"externalids":{"MAG":"2921702950","ACL":null,"DOI":"10.1615\/CRITREVEUKARYOTGENEEXPR.2019025430","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the growth of embedded systems, VLSI design phases complexity and cost factors across the globe and has become outsourced. Modern computing ICs are now using system-on-chip for better on-chip processing and communication. In the era of Internet-of-Things (IoT), security has become one of the most crucial parts of a System-on-Chip (SoC). Malicious activities generate abnormal traffic patterns which affect the operation of the system and its performance which cannot be afforded in a computation hungry world. SoCs have a chance of functionality failure, leakage of information, even a denial of services (DoS), Hardware Trojan Horses and many more factors which are categorized as security threats. In this paper, we aim to compare and describe different types of malicious security threats and how neural networks can be used to prevent those attacks. Spiking Neural Networks (SNN), Runtime Neural Architecture (RTNA) are some of the neural networks which prevent SoCs from attacks. Finally, the development trends in SoC security are also highlighted. Keywords\u2014 VLSI, System-on-Chip, Internet-of-Things (IoT), Denial-ofService, Hardware Trojan Horses Security, Spiking Neural Networks, Runtime Neural Networks","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":237352931,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2108.13307"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examined anesthetic development and hemodynamic changes during two techniques of hyperbaric lidocaine administration through 27-gauge intrathecal catheters for continuous spinal anesthesia in 55 elderly patients undergoing transurethral prostatic resection. Twenty-five patients were randomly assigned to receive hyperbaric lidocaine 5% solution in a single bolus of 75 mg to achieve blockade to approximately T6, and 30 patients to receive hyperbaric lidocaine 2.5% solution in increments of 25 mg to achieve T6 or to a maximum of three doses. Hemodynamic measurements of arterial pressure, heart rate, cardiac output, stroke volume, and ejection fraction were made serially after the induction of spinal anesthesia. Anesthesia failed to spread beyond the sacral region in 9\/25 (36%) patients in the single-dose group (SD), but was successfully induced in all patients given titrated doses (TD) at total doses of 50 mg (n = 15) (TD50) and 75 mg (n = 15) (TD75). The mean maximal level of sensory block in all three groups was comparable: T5, T4, and T6 in groups SD, TD50, and TD75, respectively. The onset and progression of sensory block were rapid and similar in the SD and TD50 groups, in contrast to a gradual, stepwise development of block in group TD75. Grade 3 motor block occurred in response to the first dose of 25 mg lidocaine in 7\/30 (23%) patients receiving titrated doses, but the overall incidence of leg paralysis did not differ among the three groups by the end of lidocaine dosing. Mean arterial pressure (MAP) decreased significantly relative to baseline in all three groups.(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32611911,"openaccessinfo":{"externalids":{"MAG":"2097064377","ACL":null,"DOI":"10.1213\/00000539-199407000-00022","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1213\/00000539-199407000-00022","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Poor pedestrian and transportation circulation, overpopulation, expensive cost of living\u2014these are some of the issues inherent to any urban metropolis around the world. As cities develop and grow, more job opportunities open up for people, which leads to the increase in city population. This growth affects the city's lifestyle, leading to overpopulation, poor circulation and expensive cost of living within the urban centre. Influenced by the concept 'time is of the essence', urban living has become synonymous to an autonomous service stuck within a loophole. This lifestyle, now further propelled by the presence of technology, can prove to be detrimental to the inhabitants' comfort and well-being. In order to adapt to an impending future of the urban areas, an alternative to future urban living using technology with a minimal yet comfortable dwelling must be provided.\u00a0\u00a0The thesis proposes that emergent technology as a design-generating tool along with ergonomic design and depictions of visionary architecture are capable of producing an alternative to urban minimal dwellings in the future. It contends that these future urban minimal dwellings can be developed by: mapping and understanding emergent technologies potentially usable in interior architecture that can be developed into tools; collecting and analysing ergonomic principles and techniques appropriate to interior architecture; collecting and analysing literature about minimal dwelling in modern history; and analysing components and technologies used in depicted living spaces within selected filmography.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":245076137,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.26686\/wgtn.17139362.v1","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/openaccess.wgtn.ac.nz\/articles\/thesis\/Tech-noiR_An_Exploration_of_Interior_Spaces_in_an_Urban_context_generated_by_Emergent_Technology\/17139362\/2\/files\/31694684.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The differential availabilities of the hydroxamate siderophores ferrioxamine B (FOB) and ferrichrome (FC) and the pseudobactin siderophores St3, 7NSK2, and WCS 358 as sources of Fe for soil and rhizosphere bacteria were studied. About 20% of the total bacterial CFU from the rhizospheres of four plant species were able to use FOB as the sole Fe source in an Fe-deficient medium, while about 12, 10, 2, and > 1% were able to use FC and pseudobactins 7NSK2, St3, and WCS 358, respectively. Of the 165 colonies isolated from plates containing pseudobactins, 64 were able to use the pseudobactin on which they were isolated as the sole Fe source in pure culture. Cross-feeding tests showed that almost all of these 64 strains were also able to use at least one of the other siderophores studied (pseudobactin, FOB, or FC). Pseudomonas putida StS2, Pseudomonas maltophilia 7NM1, and Vibrio fluvialis WS1, which were originally isolated on pseudobactins St3, 7NSK2, and WCS 358, respectively, were selected for their ability to grow with pseudobactin St3 as the sole Fe source. They incorporated 55Fe3+ mediated by pseudobactin St3 at various rates (71.5, 4, and 23 pmol\/min\/mg [dry weight] of cells, respectively). Similarly, P. putida St3 was shown to incorporate 55Fe3+ mediated by FOB and FC. We suggest that the ability of bacteria to utilize a large variety of siderophores confers an ecological advantage.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":24841245,"openaccessinfo":{"externalids":{"MAG":"2108142995","ACL":null,"DOI":"10.1128\/aem.58.1.119-124.1992","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/aem.asm.org\/content\/aem\/58\/1\/119.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract Neurogenic orthostatic hypotension (nOH) is among the most debilitating nonmotor features of patients with Parkinson's disease (PD) and other synucleinopathies. Patients with PD and nOH generate more hospitalizations, make more emergency room visits, create more telephone calls\/mails to doctors, and have earlier mortality than those with PD but without nOH. Overall, the health-related cost in patients with PD and OH is 2.5-fold higher compared with patients with PD without OH. Hence, developing effective therapies for nOH should be a research priority. In the last few decades, improved understanding of the pathophysiology of nOH has led to the identification of therapeutic targets and the development and approval of two drugs, midodrine and droxidopa. More effective and safer therapies, however, are still needed, particularly agents that could selectively increase blood pressure only in the standing position because supine hypertension is the main limitation of available drugs. Here we review the design and conduct of nOH clinical trials in patients with PD and other synucleinopathies, summarize the results of the most recently completed and ongoing trials, and discuss challenges, bottlenecks, and potential remedies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221624547,"openaccessinfo":{"externalids":{"MAG":"3084324753","ACL":null,"DOI":"10.1055\/s-0040-1713846","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7606619","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Translating evidence-based practices to the bedside can be facilitated by an active academic-practice partnership between nursing faculty and frontline nursing staff. A collaborative effort between the university's academic nurses and the medical center's clinical nurses explored, created, implemented, and evaluated an evidence-based nurse-driven protocol for decreasing the rate of catheter-associated urinary tract infections. The nurse-driven protocol was piloted in 4 intensive care units and included nurse-driven orders for catheter discontinuation, utilization of smaller bore urinary catheters, addition of silver-based cleansing products for urinary catheter care, and education of staff on routine catheter care and maintenance. Data were collected for more than 8 months pre- and postimplementation of the nurse-driven protocol. Postimplementation data revealed a 28% reduction in catheter-associated urinary tract infections in the intensive care units as compared with preimplementation. Secondary benefits of this academic-practice partnership included strengthening the legitimacy of classroom content as lessons learned were integrated into courses in the nursing curriculum. The result of the partnership was a stronger sense of collaboration and collegiality between hospital staff and the university faculty. Transformative leadership engaged numerous stakeholders through collaborative efforts to realize best practices. An academic-practice partnership facilitates transformative change and provides structural stability and sustainability.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":24166289,"openaccessinfo":{"externalids":{"MAG":"2515810028","ACL":null,"DOI":"10.1097\/CNQ.0000000000000129","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : The purpose of this report is to acquaint potential customers with the capabilities of the Reeves Electronic Analogue Computer (REAC) now in operation at RAND. The REAC does with electric circuits what the mechanical differential analyzer does with gears, shafts, and discs, but operates roughly at ten times the speed and one-tenth the accuracy. A problem of average complexity requires a few hours of REAC preparation and testing, after which individual runs can be made in a few minutes. The components of the machine have been adjusted to make the error of a single operation (addition, integration, multiplication, etc.) less than .1 percent of full scale. The machine will be particularly useful in the solution of nonlinear or implicit equations, or systems of equations which are extremely difficult to handle analytically or numerically. In an electronic differential analyzer, quantities are represented by voltages. The constant of proportionality between the voltage at a point in the circuit and the quantity it represents is referred to as the scale factor. It is the number of volts representing one unit of the quantity. In the REAC, variables must lie between +\/-100 volts, since greater values produce erroneous results. Lights and bells indicate any variable exceeding these limits. The next section will present the components which permit summation, integration, multiplication, etc., of these variables; the principles of the components are given in the appendix.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56993702,"openaccessinfo":{"externalids":{"MAG":"312394829","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The glymphatic system is a brain-wide metabolite clearance pathway, impairment of which in post-traumatic and ischemic brain or healthy aging is proposed to contribute to intracerebral accumulation of amyloid-\u03b2 and tau proteins. Glymphatic perivascular influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent publication that failed to find an effect of Aqp4 knockout on perivascular CSF tracer influx and interstitial fluid (ISF) tracer dispersion, four independent research groups have herein re-examined the importance of Aqp4 in glymphatic fluid transport. We concur in finding that CSF tracer influx, as well as fluorescently-tagged amyloid-\u03b2 efflux, are significantly faster in wild-type mice than in three different transgenic lines featuring disruption of the Aqp4 gene and one line in which AQP4 expression lacks the critical perivascular localization (Snta1 knockout). These data validate the role of AQP4 in supporting fluid and solute transport and efflux in brain in accordance with the glymphatic system model.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":196654407,"openaccessinfo":{"externalids":{"MAG":"2950344815","ACL":null,"DOI":"10.1101\/216499","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2017\/11\/09\/216499.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background Hydroxy-methyl-glutaryl Coenzyme-A reductase (HMGCR) inhibitors or statins are a well-acknowledged cause of a spectrum of myopathic consequences including an asymptomatic increase of creatine kinase (CK), myalgias, myositis and rhabdomyolysis. A unique autoantibody with specificity against 200-kd and 100-kd proteins has been recently associated with statin induced myositis (1) based on identification of cases with features of necrotizing myopathy. The 100kd autoantigen has been identified as HMGCR (2). We sought to further characterize cases of clinically suspected statin-induced myositis using clinical, serological and pathological data. Objectives The aim was to characterize statin induced myositis patients in a clinical setting and test the utility of the newly identified anti-200\/100 autoantibody. Methods Patients with a statin induced myositis were identified from a large tertiary myositis referral centre in Salford, UK. Case records of all patients were reviewed with selected patients' blood samples tested for anti-200\/100 autoantibody. Clinical features, concomitant medications, co-morbidities, immunology, electromyography (EMG), magnetic resonance imaging (MRI) and muscle biopsies for each patient were reviewed. Results 10 patients were identified with a clinical diagnosis of statin induced myositis. Mean age of diagnosis was 59 years (70% male). Median CK level detected at onset was 1,750 IU\/litre (range 28-11,984). 9\/10 patients were on a lipophilic statin (simvastatin\/atorvastatin) with 1 patient on a hydrophilic statin (rosuvastatin); mean daily dose of 39mg\/day prior to symptom onset. 5\/10 patients were on a concomitant medication known to interact with a statin (amiodarone, proton pump inhibitors, high dose vitamin D). 3\/10 patients were anti-nuclear-antibody positive (2 had low titres, 1\/100; 1 positive 1\/1000), whilst 2 patients were anti-Ro antibody positive. 6 patients demonstrated some evidence of myositis on MRI, of which 3 patients exhibited myopathic changes on EMG. 8 patients had evidence of myopathic muscle on biopsy, 2 patients with type II fibre atrophy. Of the 7 patients tested for anti-HMGCR by Western blotting using a recombinant source, 6 tested positive. 2 patients who tested strongly 200\/100 positive required immunosuppression and had biopsy features of necrosis, phagocytosis and regeneration. 2 further 200\/100 positive patients (1 strong and 1 weak positive) had occasional necrotic fibres with little regenerative activity on biopsy and did not require further treatment. The remaining 2 200\/100 positive patients had no features of necrosis on biopsy, one of whom required immunosuppression without corticosteroids. Conclusions EMG and MRI were non-specific in identifying patients with a statin induced myositis, whilst CK levels varied significantly in this group. A strongly positive anti-200\/100 antibody in combination with a necrotizing myopathy on muscle biopsy could be useful clinically to identify which patients have an autoimmune element to their disease, hence may potentially benefit from immunosuppression. References Christopher-Stine L et al. Arthritis Rheum 2010;62(9):2757\u201366. Mammen AL et al. Arthritis Rheum. 2011 Mar;63(3):713-21. Acknowledgements MJ is a MRC Clinical Training Fellow funded by the North West England Medical Research Council Fellowship Scheme in Clinical Pharmacology and Therapeutics. Disclosure of Interest None Declared","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":75902996,"openaccessinfo":{"externalids":{"MAG":"2328902516","ACL":null,"DOI":"10.1136\/ANNRHEUMDIS-2013-EULAR.1915","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We conducted a phase I\/II study in patients with advanced hepatocellular carcinoma (HCC) to determine the recommended dose, as well as the safety and efficacy, of combination therapy of sorafenib with hepatic arterial infusion chemotherapy (HAIC) using low dose cisplatin (CDDP) and 5-fluorouracil (5FU). Cohorts consisting of 3-6 patients with HCC received an escalated dose of CDDP and 5-FU until a maximum-tolerated dose was achieved. The treatment regimen was as follows: oral administration of sorafenib (400 mg twice daily for 28 days) combined with HAIC using CDDP (14-20 mg\/m2, on days 1 and 8) and 5-FU (170-330 mg\/m2, continuously on days 1-5 and 8-12) via an implanted catheter system). Each treatment cycle consisted of 28 days and three cycles of combination therapy. At the end of the first cycle, adverse events were evaluated and future dose escalation was determined. Eighteen patients with advanced HCC were enrolled. Dose-limiting toxicity was observed in two patients from cohort 1 (erythema multiforme and grade 4 thrombocytopenia) and in one patient from cohort 2 (erythema multiforme). Seven of the 18 patients achieved a partial response, seven showed stable disease, two were diagnosed as progressive disease, and two were not assessable. The response rate was 38.9% and the disease control rate was 77.8%. The time-to-progression was 9.7 months and the 1-year survival rate was 88.2%. Oral administration of 400 mg of sorafenib twice daily, 20 mg\/m2 of intra-arterial infusion of CDDP, and 5-FU at 330 mg\/m2 are the recommended doses for combination therapy, which was well tolerated and efficacious. This combination therapy may be a promising treatment for patients with advanced HCC. A large prospective randomized multicenter study (ClinicalTrials.gov Identifier NCT01214343) is ongoing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28214411,"openaccessinfo":{"externalids":{"MAG":"2238432908","ACL":null,"DOI":"10.1159\/000367751","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.karger.com\/Article\/Pdf\/367751","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The requirement for external quenching circuits adds substantially to the complexity and processing difficulty for InGaAs single-photon detectors, particularly in array configurations. Using bandgap engineering, we have developed InGaAs SPADs with self-quenching and self-recovering capabilities. The quenching process occurs in less than 100 ps, determined by the gain buildup time and the magnitude of device overbias. On the other hand, the recovery time is determined by the carrier escape time over an energy barrier that is typically tens of meVs. The recovery time can range from 1 ns to > 100 ns from the design of device and material structures. The optimal recovery time is a function of dark count rate and afterpulsing rate. Our data show that a recovery time of around 10 ns is near the optimum in most operation conditions. The self-quenched SPADs also show great suppression in excess noise, yielding a very uniform intensity distribution of output response to single photons. This unique property favors resolving photon number in an array device. As in conventional InGaAs SPADs, the single-photon detection efficiency increases with the amount of overbias (bias above breakdown voltage) and so does the dark count rate. A detection efficiency of 13-16% is obtained while still keeping the dark count and afterpulsing rates low. To our knowledge, the self-quenched InGaAs SPAD is the only device in its class to be able to operate under DC bias without gating or external circuits. As a result, the device is particularly suitable for array structures often used in communications, sensing, and imaging.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":119644354,"openaccessinfo":{"externalids":{"MAG":"1979028258","ACL":null,"DOI":"10.1117\/12.819950","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The use of Digital Library (Digilib) has grown rapidly. As a library management information system that can assist users to search for references, it cannot be denied that the establishment of Digilib has assisted numerous students. In order for information technology to improve organizational performance, the technology must be accepted and utilized by its users. This quantitative research aims to identify students' perceptions of digital library at the Central Library, Universitas Indonesia. A questionnaire is distributed to 109 respondents. The data analysis employs structural equation model toward the Unified Theory of Acceptance and Use of Technology (UTAUT) model. The results of the analysis show that performance expectation significantly affects the behaviour intention of digital library users. On the other hand, effort expectation, social influence, and facilitating condition do not influence behaviour intention. Meanwhile, behaviour intention has a significant effect on use behaviour. The implication of this findings is that the Central Library of Universitas Indonesia should improve the digital library so that it can support the student centred active learning at the university.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":85521102,"openaccessinfo":{"externalids":{"MAG":"2920330404","ACL":null,"DOI":"10.4108\/EAI.7-12-2018.2281760","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reports a novel design of a swept-frequency, swept-power, microwave automatic impedance measuring scheme using multiple probes and low-frequency signal processors. It can be used, for example, in FM radar or microwave-communication-system monitoring and nonlinear, swept-frequency, real-time \/bar z\/-measurements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108419879,"openaccessinfo":{"externalids":{"MAG":"1862709808","ACL":null,"DOI":"10.1109\/MWSYM.1980.1124193","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: to characterize the efcacy of nelfnavir and lopinavir\/ritonavir in the starting regimens of antiretroviral therapy for HIV-infected pediatric patients. Materials and methods: 50 HIV-infected patients aged 24-36 months were treated with abacavir and lamivudine in combination with nelfnavir (24 children) or lopinavir\/ritonavir (26 patients). Results: Using both antiretroviral therapy schemes leads to suppression of HIV replication, improvement of clinical and immunological parameters. However, the treatment with lopinavir\/ritonavir revealed a signifcant positive changes of HIV blood viral load, immune status and clinical picture. With the help of mathematical modeling, the signifcance of lopinavir\/ritonavir appointment as an independent predictor of effectiveness prolongation of antiretroviral therapy has been proved. As a side effect of lopinavir\/ritonavir developed dyspeptic symptoms. Conclusion: Te results of the study indicate the high efcacy and safety of lopinavir\/ritonavir use compared to nelfnavir in HIV-infected pediatric patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59507952,"openaccessinfo":{"externalids":{"MAG":"2949479175","ACL":null,"DOI":"10.21886\/2219-8075-2018-9-4-22-27","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.medicalherald.ru\/jour\/article\/download\/737\/482","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We present a novel method named truncated hierarchical unstructured splines (THU-splines) that supports both local $h$-refinement and unstructured quadrilateral meshes. In a THU-spline construction, an unstructured quadrilateral mesh is taken as the input control mesh, where the degenerated-patch method [18] is adopted in irregular regions to define $C^1$-continuous bicubic splines, whereas regular regions only involve $C^2$ B-splines. Irregular regions are then smoothly joined with regular regions through the truncation mechanism [29], leading to a globally smooth spline construction. Subsequently, local refinement is performed following the truncated hierarchical B-spline construction [10] to achieve a flexible refinement without propagating to unanticipated regions. Challenges lie in refining transition regions where a mixed types of splines play a role. THU-spline basis functions are globally $C^1$-continuous and are non-negative everywhere except near extraordinary vertices, where slight negativity is inevitable to retain refinability of the spline functions defined using the degenerated-patch method. Such functions also have a finite representation that can be easily integrated with existing finite element or isogeometric codes through B\\'{e}zier extraction.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":263793990,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2104.00090"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Procaine hydrochloric acid, a cationic anesthetic, although unable to prevent the effect of calcium ionophore A23187 on erythrocytes, inhibited the discocyte--echinocyte transformation, increased viscosity, and decreased filterability of red cells undergoing ATP depletion. The effects were abolished by washing ATP-depleted, procaine HCl-treated red cells prior to these determinations. Procaine HCl had no effects on volume, incubated osmotic fragility, or monovalent cation composition of ATP-depleted red cells. The drug increased 45Ca uptake by ATP-depleted red cells but did not change the fraction of membrane-bound calcium. Sodium dodecyl sulfate acrylamide gel electrophoresis of membrane proteins from ATP-depleted red cells revealed formation of high molecular weight protein complexes, which were not formed when biconcave shape and ATP content were maintained by incubation with adenine (0.54 mM) and inosine (12.7 mM); Formation of these complexes was not prevented when the biconcave shape was maintained by procaine HCl. It was concluded that the maintenance of the biconcave shape and normal deformability during ATP depletion by procaine HCl was not related to a displacement of membrane-bound calcium and inhibition of ATP-dependent rearrangement of red cell membrane proteins.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":6613009,"openaccessinfo":{"externalids":{"MAG":"1585483927","ACL":null,"DOI":"10.1182\/BLOOD.V50.1.155.155","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper addresses some advances in the theoretical description of molecular spectroscopy beyond the Born-Oppenheimer adiabatic approximation. A solution of the nuclear dynamics problem complicated by the EE Jahn-Teller effect and spin-orbit coupling is considered for the case of the CF3O and CF3S radicals, all the model parameters being obtained solely from ab initio calculations without any adjustment to experimental numbers. Vibrational and vibronic model parameters were calculated at the equation-of-motion coupled cluster level of theory with basis sets of triple-zeta quality. The spin-orbit coupling in X 2E CF3O and CF3S was parametrized by means of a perturbative solution of the full Breit-Pauli spin-orbit operator. Spin-vibronic eigenvalues and eigenfunctions were computed in a basis set of products of electronic, electron spin, and vibrational functions. Results demonstrate the importance of explicit inclusion of the spin-orbit coupling and at least cubic Jahn-Teller terms in the model Hamiltonian for the high precision evaluation of spin-vibronic energy levels of CF3O and CF3S. The theoretical results support and complement the spectroscopic data observed for these species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10531908,"openaccessinfo":{"externalids":{"MAG":"2074553337","ACL":null,"DOI":"10.1021\/JP070495F","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this fascinating and generously illustrated book, Romy Golan explores mural and mural-like works in Europe from the 1920s to the 1950s, beginning with Monet's installation of the Nympheas at the Musee de l'Orangerie in Paris, and ending dramatically with Le Corbusier's huge tapestries in Chandigarh, India. Many artists and critics looked to the mural as a corrective to the ills of painterly Modernism: the disruption of the pictorial field at the hands of Cubism and other avant-garde practices; the commodification of painting through the market for easel paintings; and more generally the alienation of man and the anomie of art in the modern condition. At the same time it was clear that a return to the mural format would never be more than an anachronistic and futile gesture. This book is therefore about mural paintings that are not convinced they belong on walls: such strange objects as mosaics designed to be disassembled; paintings that resemble large-scale photographs, or photomurals; and tapestries that functioned as portable woolen walls. The author argues that the uncertain relation of these objects to the wall is symptomatic of the dilemmas that troubled European art, artists, and architects during the middle decades of the twentieth century.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":190917435,"openaccessinfo":{"externalids":{"MAG":"618265462","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We implement the conformal bootstrap program for three dimensional conformal field theories with N=2 supersymmetry and find universal constraints on the spectrum of operator dimensions in these theories. By studying the bounds on the dimension of the first scalar appearing in the operator product expansion of a chiral and an antichiral primary, we find a kink at the expected location of the critical three dimensional N=2 Wess-Zumino model, which can be thought of as a supersymmetric analog of the critical Ising model. Focusing on this kink, we determine, to high accuracy, the low-lying spectrum of operator dimensions of the theory, as well as the stress-tensor two-point function. We find that the latter is in an excellent agreement with an exact computation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37295906,"openaccessinfo":{"externalids":{"MAG":"2142740306","ACL":null,"DOI":"10.1103\/PhysRevLett.115.051601","PubMedCentral":null,"ArXiv":"1502.04124"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Examination of 88 extracranial carotid arteries using CW Doppler spectrum analysis is compared with the findings of transfemoral conventional arteriography. There is no significant difference (P greater than 0.05) between CWD and angiographic results, although sensitivity, specificity and accuracy are superior for the latter technique. CWD spectrum analysis can underestimate complete occlusion and misinterpret the degree of stenosis, however it is a cheap and rapid procedure that can be used to judge whether particular symptoms are due to identifiable disease and whether selective carotid arteriography is advisable.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44712083,"openaccessinfo":{"externalids":{"MAG":"2467093850","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The comprehensive index of environmental and economic development is calculated through applying multi-objective grey analytic hierarchy process (AHP), the coordination degree of influencing factors in the system of economy and environment is explored, as well as the coupling model of regional economy and environment system is established based on Mode Coupling Theory, then the coordination degree of influencing factors in environmental carrying capacity has been performed with quantitative analysis through taking Xi'an as an example.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":158824965,"openaccessinfo":{"externalids":{"MAG":"2804369442","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Actin dynamics is critical for the formation and sustainment of the immunological synapse (IS) during T cell interaction with antigen-presenting cells (APC). Thus, many actin regulating proteins are involved in spatial and temporal actin remodeling at the IS. However, little is known whether or how actin stabilizing protein controls IS and the consequent T cell functions. TAGLN2 \u2212 an actin-binding protein predominantly expressed in T cells \u2212 displays a novel function to stabilize cortical F-actin, thereby augmenting F-actin contents at the IS, and acquiring leukocyte function-associated antigen-1 activation following T cell activation. TAGLN2 also competes with cofilin to protect F-actin in vitro and in vivo. During cytotoxic T cell interaction with cancer cells, the expression level of TAGLN2 at the IS correlates with the T cell adhesion to target cancer cells and production of lytic granules such as granzyme B and perforin, thus expressing cytotoxic T cell function. These findings identify a novel function for TAGLN2 as an actin stabilizing protein that is essential for stable immunological synapse formation, thereby regulating T cell immunity. [BMB Reports 2015; 48(7): 369-370]","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16590515,"openaccessinfo":{"externalids":{"MAG":"2317155247","ACL":null,"DOI":"10.5483\/BMBRep.2015.48.7.132","PubMedCentral":"4577284","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Field experiments were conducted in acidic soils of Mangalpur and Fulbari Village Development Committees in western Chitwan, Nepal to study the effects of different land use systems on soil properties and earthworm dynamics. Seven land use systems (cereal based lowland, cereal based upland, vegetable farm land, fruit orchard land, pasture land, forest land and farmer's field) were used and they were replicated four times in randomized complete block designs. Soil organic matter and total soil nitrogen were significantly higher from pasture land (4.7 % and 0.2 %) and the lowest were from farmer's field (2.4 % and 0.1 %). However, available soil phosphorous content was significantly higher from cereal based upland (448.3 kg ha-1) and it was the lowest from forest land (13.0 kg ha-1). The highest earthworm count was observed from pasture land (10.1 numbers per trap) than others but it was the lowest from farmer's field. There were significant positive correlations between soil organic matter content and the earthworm count (r= 0.96**) and between total soil nitrogen content and earthworm count (r= 0.80**). In contrast, a significant negative correlation was observed between earthworm count and available P (r= -0.51**). Correlation between earthworm count and silt content was positive (r= 0.68**) but between earthworm count and sand content was negative (r= -0.64**). However, there were no significant relationships of earthworm count with available K, pH, bulk density and clay content of soils. The soil organic matter, total soil nitrogen and earthworm count were higher from pasture soil than other soils. As soil organic matter, total soil N, available soil P and soil texture regulated earthworm dynamics in soils. Earthworm population may be used as a bio-indicator of soil fertility status and it can be developed as an alternative technique for soil fertility evaluation after quantification and verification from further experiments on earthworm dynamics under different land use systems.Journal of the Institute of Agriculture and Animal Science.Vol. 33-34, 2015, page: 123-128","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":130055660,"openaccessinfo":{"externalids":{"MAG":"2886507837","ACL":null,"DOI":"10.3126\/JIAAS.V33I0.20694","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract This study explores how vulnerable refugees' experiences in the first year after being granted leave to remain in the UK impact on mental health and wellbeing. Nine semi-structured interviews were conducted with refugee survivors of extreme cruelty. Data were analyzed using thematic analysis with a narrative influence. Reported challenges included requirements to organize housing, finances and welfare benefits rapidly. Most respondents reported low mood, worry, exacerbated PTSD symptoms, physical ailments and isolation, but valued stable housing, meaningful activities, emotional support and service provider sensitivity in managing this transition. Policy and service recommendations are made, to assist integration and improve wellbeing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":210465305,"openaccessinfo":{"externalids":{"MAG":"2982001027","ACL":null,"DOI":"10.1080\/15562948.2019.1677974","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/discovery.ucl.ac.uk\/id\/eprint\/10085860\/1\/Morant_Refugees%20Who%20Have%20Experienced%20Extreme%20Cruelty_A%20Qualitative%20Study%20accepted%20version.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The objective of this study was to explore psychosocial factors underlying decisions about use of prenatal diagnosis for cystic fibrosis (CF), among parents of affected children. Anonymous survey questionnaires, supplemented by voluntary interviews, were used at 12 CF centers in six New England states, for a consecutive sample of families of minor children visiting CF centers during a 4-mo period. In all, 227 (71%) of 318 families responded. We hypothesized that attitudes toward utilization would be affected by (a) intentions to have children, (b) knowledge, (c) perception of risk, (d) the health of the child with CF, (e) expectations about the child's future, (f) attitudes toward abortion, (g) insurance, (h) genetic counseling, and (i) sociodemographic factors (including attendance at religious services). Of the 227 couples who responded, 69% were surgically sterile, over 45 years of age, widowed, or divorced, and 31% were at risk. Of 70 at-risk couples, 44% intended to have more children; of these, 77% had had or were considering CF prenatal diagnosis. Most families knew CF could be diagnosed prenatally; 20% would terminate for CF. Among intended prenatal diagnosis users, 44% would carry a fetus with CF to term, 28% would abort, and 28% were undecided. Stepwise logistic regression showed three variables significantly related to intentions to use prenatal diagnosis: (1) respondent's willingness to abort for CF (P less than .02, odds ratio 3.36), (2) respondent's siblings' approval of abortion for CF (P less than .03, odds ratio 2.99), and (3) respondent listed no accomplishments for the child with CF (P less than .09, odds ratio 3.01). The majority of affected families reject selective abortion for CF; many will curtail childbearing rather than use prenatal diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33093420,"openaccessinfo":{"externalids":{"MAG":"174829579","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTIONOver the past half-century, feminist economists have transformed our understanding of how the world economy functions. They have critiqued the gender-blindness of traditional economic models and challenged analytic descriptions of development and globalization that ignore much of women's economic activity. Feminist economists have developed analytical frameworks for examining gender relations that permeate political, social, and economic institutions including markets, governments, households, and firms. They have produced new methodologies that incorporate women's experiences in economic models, statistics, and the evaluation of economic phenomena. Their research has pushed the boundaries of knowledge by challenging conventional paradigms and concepts, ideas and categories that were engrained and therefore rarely scrutinized.1The result has been the emergence of a new consensus. Welldocumented studies have shown that the erosion of systems of patriarchy not only empowers women economically, but also has demonstrably positive impacts on alleviating poverty and promoting human development. These changes in our understanding of the development process have produced a new politics as well as new forms of economic development policy. Key international institutions, donor agencies, and governments have adopted gender-sensitive policies in their development programs as part of 'gender mainstreaming,' or the process of institutionalizing gender-sensitive analysis and policy in governments and organizations.2 Advocates have also used feminist knowledge of development to strengthen women's groups raising gender issues in broader social and political movements. Knowledge of feminism allows for greater clarity of the vision of social change and has served as a guide for consciousness-raising, thus enabling feminist research to be transformative at the grassroots level. This dynamic interaction between feminist thinking and feminist activism has revealed tensions regarding the intersections of knowledge, power, and development outcomes.3 It has led to debates among feminist economists in terms of what needs to be done and how best to accomplish gender equality. These tensions and debates are necessary and vital in pushing the boundaries of knowledge and in deepening our understanding of development.Despite this headway, several important challenges remain. The progress we can document has been halting and uneven. Moreover, in certain key areas of economic policy-making, gender-sensitive economic policy is absent, and approaches used in gender mainstreaming to assess the differential effects of a policy on women and men can sometimes legiti- mize women's subordinate roles. Rather than treating the promotion of human rights and women's well-being as ends in themselves, their labor and productivity potential are viewed mainly as means to further increase economic growth. The important focus on long-run transformation of gender relations toward equality in the context of regional, national, and global economic processes is, more often than not, neglected, particularly when countries face economic crises. The very real setbacks women experience as a result of the gender-blind management of the economy during booms and downturns have long-term consequences. In this time of increasing economic disruptions, it will be important to systematically integrate the promotion of gender equality in the implementation of appropriate economic stabilization policies.First, we explore the link between dismantling systems of male dominance and our understanding of the development process, with a particular focus on what is required to achieve the recently adopted Sustainable Development Goals (SDGs).4 We then turn to interventions from key international organizations in order to illustrate the impact that feminist economics has had on development policymaking. We then argue that, despite some advancements, several missing elements in the development of economic policy still allow unequal gender relations to persist or create new forms of gender inequalities. \u2026","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":157930325,"openaccessinfo":{"externalids":{"MAG":"2602492686","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two patients with an ossicle of the meniscus are described. Radiologic differentiation from osteochondral loose body or chondrocalcinosis can be made by its ossified appearance and its location within the meniscus. Correct diagnosis is important so that unnecessary surgery is avoided and a protracted search for a free fragment is not carried out.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30779122,"openaccessinfo":{"externalids":{"MAG":"2008029928","ACL":null,"DOI":"10.2214\/AJR.127.5.785","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effects of ischemia-reperfusion on the light-evoked alkalinization, which reflects the metabolism of rod photoreceptors, were studied in the dark-adapted cat retina in vivo. We recorded the pH value in the extracellular space surrounding rod photoreceptors with double-barreled H(+)-selective microelectrodes. The light-evoked alkalinizations at the outer nuclear layer were diminished during reperfusion after 10-30 min of ischemia which was induced by an increase of the intraocular pressure above the arterial systolic pressure. This result suggests that the rod metabolism might be suppressed during reperfusion after ischemia.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3279462,"openaccessinfo":{"externalids":{"MAG":"2061719264","ACL":null,"DOI":"10.1159\/000267339","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Evolutionary algorithms (EAs) are population-based global search methods. Memetic Algorithms (MAs) are hybrid EAs that combine genetic operators with local search methods. With global exploration and local exploitation in search space, MAs are capable of obtaining more high-quality solutions. On the other hand, mixed-integer hybrid differential evolution (MIHDE), as an EA-based search algorithm, has been successfully applied to many mixed-integer optimization problems. In this paper, a mixed-integer memetic algorithm based on MIHDE is developed for solving mixed-integer constrained optimization problems. The proposed algorithm is implemented and applied to the optimal design of batch processes. Experimental results show that the proposed algorithm can find a better optimal solution compared with some other search algorithms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122430887,"openaccessinfo":{"externalids":{"MAG":"2094467478","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMM.300-301.645","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was designed to investigate effects of calcium antagonists on endothelial and neuronal dysfunction of right coronary artery (RCA) induced by ischemia- reperfusion in anesthetized, open-chest pigs. After reperfusion, pigs were sacrificed and the RCA was rapidly dissected for in vitro experiments. Experimental groups were divided into 4 groups: control (C-RCA), ischemia-reperfusion only (I-RCA), verapamil infusion (VI-RCA) and nifedipine infusion (NI-RCA) group, respectively. The ischemia did not affect hemodynamics, mean arterial pressure, heart rate, LV dP\/dt max, and decreased RCA flow. Arterial pressure and heart rate during ischemia-reperfusion were decreased in VI-RCA and NI-RCA, and RCA flow during reperfusion was increased in NI-RCA. 5-Hydroxytryptamine (5-HT) produced concentration- dependent contractions in C-RCA. The 5-HT-induced contractions were potentiated in I-RCA and VI-RCA, but not in NI-RCA. Endothelium-dependent relaxation by calcium ionophore A23187 was inhibited in I-RCA and VI-RCA, and recovered in NI-RCA. Cyclic GMP contents were decreased in I-RCA group alone. Electrical field stimulation in C-RCA produced transient and frequency-dependent contractions and at 50 Hz caused biphasic contractions. The transient contractions were not affected by pretreatment with phentolamine and atropine, but the biphasic contraction was altered by the pretreatment. Both contractions were inhibited in I-RCA, and were partially recovered in VI-RCA and NI-RCA. Ischemia- reperfusion of RCA in pigs causes endothelial and neuronal dysfunctions, and calcium antagonists partially prevent both.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":89120723,"openaccessinfo":{"externalids":{"MAG":"2398958116","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nPatients with activating epidermal growth factor receptor (EGFR) mutations display drastic initial responses to erlotinib, but tumor reduction and progression-free survival vary widely. An open question is whether response variation derives, in part, from tumor heterogeneity, i.e., differential composition of cells responding to erlotinib with distinct cell fates (death, division, or quiescence). Conventional assays obscure response heterogeneity by taking average measurements of cell populations. To address this question we developed high-throughput live-cell imaging assays that quantify both subpopulation growth dynamics and cell-to-cell fate variability in response to drug. The Dynamic Colony Growth Assay (DCGA) tracks simultaneously the erlotinib response of hundreds of single-cell-derived colonies from within a cell population. In the PC9 lung cancer cell line (widely used to model oncogene addiction, exon19del EGFR) the DCGA reveals that individual colonies span a wide range of erlotinib response, from continued cell division to massive apoptosis. Plotting net growth rates of 207 colonies shows that PC9 parental is comprised of a normally-distributed aggregate of individual single colonies responding to erlotinib with steady-state growth rates from positive to negative. Notably, the positive-growth colonies lie in the tail of this response distribution, suggesting they do not originate from rare genetic variants or cancer stem cells but, rather, are part of a continuous response distribution that is an attribute of parental PC9. To determine whether isolated PC9 colonies maintain unique rate responses, we expanded random-sampled single cells (without erlotinib selection) into 7 discrete sublines (DS), which remain highly sensitive to erlotinib (IC50 \u223c50nM). In each DS, erlotinib induced an initial non-linear growth period (72h) followed by a distinct steady-state growth rate that predicts the long-term (10d) response. DS steady-state growth rates were resolved into individual cell fate composition by Fractional Proliferation Assays (FPA). As expected from random selection, the growth rates of treated DS clustered around the median of the DCGA rate distribution, missing the most extreme, less frequent erlotinib responses. Isolating the greatest variance in erlotinib response should facilitate identification of molecular mechanisms underlying drug response variation. Therefore, we isolated 96 new DS and selected the two with highest (DS-B03) and lowest (DS-C03) erlotinib steady state growth rate. We are currently measuring the activity of hundreds of proteins in these two DS by Microwestern Arrays to discover protein signatures and\/or mechanistic models that quantitatively link FPA-resolved cell fates to underlying signaling network events. Thus tumor response variability and recurrence may be explained by a continuous distribution of erlotinib response at the level of single cells within a tumor.\n\nCitation Format: Peter L. Frick, Darren R. Tyson, Shawn P. Garbett, Carlos F. Lopez, Zach W. Jones, Vito Quaranta. Quantifying erlotinib response variability in EGFR-addicted cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4626. doi:10.1158\/1538-7445.AM2013-4626","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":88021458,"openaccessinfo":{"externalids":{"MAG":"2329687065","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-4626","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We introduce a stochastic variational inference procedure for training scalable Gaussian process (GP) models whose per-iteration complexity is independent of both the number of training points, $n$, and the number basis functions used in the kernel approximation, $m$. Our central contributions include an unbiased stochastic estimator of the evidence lower bound (ELBO) for a Gaussian likelihood, as well as a stochastic estimator that lower bounds the ELBO for several other likelihoods such as Laplace and logistic. Independence of the stochastic optimization update complexity on $n$ and $m$ enables inference on huge datasets using large capacity GP models. We demonstrate accurate inference on large classification and regression datasets using GPs and relevance vector machines with up to $m = 10^7$ basis functions.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":219303674,"openaccessinfo":{"externalids":{"MAG":"3033768482","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2006.03015"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A survey was distributed to members of the Ecological Society of America in 2014, which asked respondents to rate the usefulness of 131 of the most common, current ecological concepts. As part of the survey, key demographic and professional information was requested from respondents, including age, gender, education level, sector of employment, and primary area (i.e., domain) of interest in ecology. This paper reports how those factors interacted and affected concept ratings. Comprehensive analysis revealed many significant patterns. Among these, we discovered that concept ratings almost invariably increased with age, often dramatically. Also, there was a very strong tendency for males to rate concepts, in general, higher than did females, but the magnitudes of these differences were small. Furthermore, there was a significant gulf between the academic and government employment categories, characterized by academic respondents having rated most concepts higher. This research is important to the ecological community as a quantitative description of the kinds of variation existing among its constituents in terms of types and degrees of concept utility. Self\u2010knowledge is critical for understanding the discipline and for advancing its educational, research, and environmental initiatives.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":133076798,"openaccessinfo":{"externalids":{"MAG":"2931612204","ACL":null,"DOI":"10.1002\/ECS2.2652","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nF14512 is a novel polyamine-vectorized topoisomerase II inhibitor currently in phase 1\/2 clinical trial in acute myeloid leukemia (AML). Since ABCB1 (also called P-glycoprotein or MDR1) has been reported to be expressed at high levels in patients with resistant leukaemia cells, and constitutes a pejorative marker of therapy, we decided to investigate whether F14512 could be exported by ABCB1 or other ABC transporters susceptible to confer drug resistance to chemotherapy, such as MRP1. In addition, we established a F14512-resistant cell line to study the mechanism of resistance to the drug.\n\nWith membrane preparation enriched in functional MDR1, we found that [F14512][1] was unable to stimulate the ATPase activity of this transporter. Using a cellular assay over expressing MDR1 transporter by recombinant transfection of MDCKII cells, [F14512][1] was detectable, but the intracellular level was unchanged regardless of the MDR1 status or in presence of MDR1 competitors. Consistently, iterative selection of a [F14512][1]-resistant A-549 cell line with 36 cycles of [F14512][1] at cytotoxic doses (0.5 EC50) over 9 months, led to only moderate shift of resistance (9 fold). In the resulting selected A-549 subclones, MDR1, MRP1 and ABCG2 were detectable at the basal level.\n\nThe ability of [F14512][1] to bypass MDR1 was finally assessed in a vinorelbine-resistant P388 model overexpressing high level of functional ABCB1 as indicated with the positive rhodamine export assay and cross resistance to MDR1 substrate. Moreover, [F14512][1] displays strong antileukemic activity in MDR1-positive P388 cells in vitro and additional in vivo measurements are in progress.\n\nIn conclusion, the data concur to show that the antitumor activity of the targeted cytotoxic agent [F14512][1] is not impacted by the MDR1 status of cancer cells. MDR1 clearly does not affect the potency of [F14512][1] and this characteristic augurs well for the ongoing development of the drug in AML patients.\n\nCitation Format: Jean Philippe Annereau, Viviane Brel, William Riquet, Laurent Creancier, Isabelle Vandenberghe, Emmanuel Fournier, Celine Robichon, Aline Stennevin, Vanessa Offrete, Laurence Lacastaigneratte, Bruno Gomes, Anna Kruczynski, Christian Bailly, Nicolas Guilbaud. F14512, a novel vectorized topoiserase II inhibitor, bypasses MDR1 mediated resistance. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 988. doi:10.1158\/1538-7445.AM2013-988\n\n [1]: \/lookup\/external-ref?link_type=GEN&access_num=F14512&atom=%2Fcanres%2F73%2F8_Supplement%2F988.atom","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":75713553,"openaccessinfo":{"externalids":{"MAG":"2322788556","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-988","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Graph Neural Networks (GNNs) have achieved great success in representing data with dependencies by recursively propagating and aggregating messages along the edges. However, edges in real-world graphs often have varying degrees of difficulty, and some edges may even be noisy to the downstream tasks. Therefore, existing GNNs may lead to suboptimal learned representations because they usually treat every edge in the graph equally. On the other hand, Curriculum Learning (CL), which mimics the human learning principle of learning data samples in a meaningful order, has been shown to be effective in improving the generalization ability and robustness of representation learners by gradually proceeding from easy to more difficult samples during training. Unfortunately, existing CL strategies are designed for independent data samples and cannot trivially generalize to handle data dependencies. To address these issues, we propose a novel CL strategy to gradually incorporate more edges into training according to their difficulty from easy to hard, where the degree of difficulty is measured by how well the edges are expected given the model training status. We demonstrate the strength of our proposed method in improving the generalization ability and robustness of learned representations through extensive experiments on nine synthetic datasets and nine real-world datasets. The code for our proposed method is available at https:\/\/github.com\/rollingstonezz\/Curriculum_learning_for_GNNs.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":264590634,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2310.18735","PubMedCentral":null,"ArXiv":"2310.18735"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this book a new structure of 1-N coder which is a part of an ADC architecture is implemented and compared with priority encoder which is another alternative(it is explained as well). 2:1 muxes are used in the architecture of 1-N encoder. Also the study includes shematic and layout apperance of other blocks. Cadence IC 5141 package and CMOS TSMC 0.18um library are used in the design. The power consumption is 30uw under the power supply -0.9 to +0.9 and effective area of the chip is 2400 micrometers square. Flash ADC architecture is the most simple one , thats way this type of ADC is presented . Simulation results which are enough to understand how ADCs work are also presented for both alternative. Aditionally ADC parameters (static and dynamic) and other ADC architectures is mentioned with details.Finally It is possible to learn from this book main concepts of microelectronics and how digital and analog CMOS circuits work. Readers can design a flash ADC easily with other alternatives after examine this study. I believe that informations included in this book is fine to begin with ADCs and microelectronics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":2}},"corpusid":195973435,"openaccessinfo":{"externalids":{"MAG":"2605150268","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rupture of the diaphragm is almost always due to major trauma and is most commonly associated with road-traffic accidents. We report a case of delayed presentation of a 35-year-old woman with a ruptured diaphragm, 11 days following apparent minor blunt trauma. This case illustrates how the diagnosis of ruptured diaphragm can be missed and demonstrates the importance of considering this diagnosis in all cases of blunt trauma to the trunk. It also demonstrates the potential pitfall of misinterpreting the chest radiograph, and the value of repeat imaging after insertion of a nasogastric tube.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29649629,"openaccessinfo":{"externalids":{"MAG":"2149306418","ACL":null,"DOI":"10.1017\/S148180350000926X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pharmaceuticals are very useful in treating human diseases but they are excreted to the environment sometimes in their original form or as byproducts of human metabolism. Pharmaceuticals and their metabolites have been proven by studies to be harmful to non-target ecological species and may be persistent in different water matrices. In this regard, there is an emergent need to eliminate these compounds to prevent their adverse effects on aquatic species. Biodegradation using white-rot fungi is a promising technology for the removal of recalcitrant compounds; however, products of fungal biodegradation can also be detrimental. In this novel study, we evaluated the ability of Phanerochaete chrysosporium to degrade amlodipine, an anti-hypertensive drug which was recently found in water systems. Analysis of amlodipine metabolites was done using quadrupole time-of-flight liquid chromatography mass spectrometry after the degradation set-up of 120 hours. Pharmaceutical degradation was seen using triple quadrupole liquid chromatography tandem mass spectrometry. Ninety-two significant metabolites (P-value \u2264 0.05) were significantly expressed after false discovery rate adjustment at a significance threshold of q = 0.05. Pyridine derivatives which were identified from samples became the basis of the proposed degradation pathway of amlodipine in this study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26535053,"openaccessinfo":{"externalids":{"MAG":"2432660400","ACL":null,"DOI":"10.2166\/wst.2015.317","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.2166\/wst.2015.317","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The oral route by so far, has always been the preferred route of drug delivery because it was the easiest and most convenient of non-invasive administration. But oral route possesses problems such as to poor bioavailability, hepatic metabolism, lack of dose proportionality.Therefore, developing suitable formulation for such active pharmaceutical ingredients (API) present a major challenge to pharmaceutical scientist. The purpose of study was to formulate solid self emulsifying drug delivery system containing Ketoprofen as sustain release dosage form. The aim of present research was to formulate Liquid SEDDS which contains the drug ketoprofen, oleic acid (oil), Tween 80 (surfactant) and Ethanol (Co-surfactant). The ratio of this component in this formulation was 22.50:25.8:51.6 9(w\/w) and optimized by pseudo ternary diagram. The droplet size of optimized liquid with drug was 111.11nm and solid SEDDS 965nm. Silicon dioxide was used as adsorbent agent. The formulation was characterized for in-vitro studies. The work was aimed to increase dissolution rate as compared to other oral dosage forms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":73610180,"openaccessinfo":{"externalids":{"MAG":"2594013072","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BackgroundDairy cows are at the highest risk of developing clinical and subclinical diseases and disorders in the first few weeks following parturition. During the periparturient period, from approximately 30 days before calving to 30 days postpartum, the immune system of the dairy cows undergoes a multitude of changes to prepare for parturition, colostrum production and lactation. One such change is the transfer of a large amount of immunoglobulin G proteins, especially subclass IgG1 to colostrum, leading to a reduction of IgG1 in the blood. As IgG1 and IgG2 need to maintain a balance to protect animals from intracellular and extracellular pathogens, a disruption of this balance compromises the immune protection of the animals. Rapid tests that can detect these immunological changes may be potentially useful for predicting the risk of dairy cows developing infectious diseases and other adverse health conditions following parturition. ResultsWe report here a new rapid test to detect certain immune status changes in the blood serum of dairy cows. This test uses a nanoparticle probe to evaluate the relative quantity of IgG1 and IgG2 in a sample. The nanoparticle probes are aggregated together upon interaction with bovine IgG2, while bovine IgG1 inhibits such interactions. The nanoparticle aggregates are detected by monitoring the color change of the assay solution using a handheld device. We tested the serum samples from 230 dairy cows collected during periparturient period, from 14-7 days before calving to 7-14 days postpartum. Results show that the test clearly detected an immune status change associated with IgG1\/IgG2 relative quantity change around the time of parturition. Data analysis using mixed liner model in SAS (Statistical Analysis System) revealed a significant difference (P value = 0.042) in their test responses between healthy cows and cows with mastitis and\/or lameness. ConclusionThe new rapid test we report here can be used to detect and monitor certain immune status change in dairy cows during the periparturient period. The test results may be potentially used to evaluate and predict the health risk of the dairy cows following parturition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":230579262,"openaccessinfo":{"externalids":{"MAG":"3113035783","ACL":null,"DOI":"10.21203\/rs.3.rs-73170\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-73170\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Recent events in the workplace, government, and college campuses in the US have brought the issues of sexual harassment and assault to the forefront of media and public discussion. Industrial and organizational (I-O) psychologists are uniquely suited to help address these issues by aiding in intervention development. Specifically, I-O psychologists can provide key insight regarding the context, design, development, and evaluation of sexual harassment and assault training efforts. Although some empirical evidence suggests that trainings are effective in the short term, there is little evidence to suggest long-term attitudinal or behavioral change outside of the training environment. Much of the research in this area, however, has focused solely on the training intervention, excluding the pre- and post-training environment. Thus, the present effort focuses on designing trainings that promote transfer, as well as improving measurement of desired outcomes, to provide a framework for improving sexual harassment and assault training. This framework addresses how individual differences, needs analysis, training design, evaluation, and post-training support contribute to lasting change while addressing the unique challenges associated with sexual harassment and assault. Last, this framework provides guidance for improving research in this area as well as practical suggestions for improving training programs.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":181392874,"openaccessinfo":{"externalids":{"MAG":"2946615301","ACL":null,"DOI":"10.1017\/iop.2018.155","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study investigated the feasibility of the bread making process with the mixture of the functional rice flour. The bread was manufactured with 20, 30 or 40% functional rice flour with increasing and wheat flour. Gelatinization characteristics of the rice starch was examined by differential scanning calorimetry(DSC). Coated with soluble dietary fiber rice showed the highest gelatinization enthalphy among functional rices and other functional rices were similar to normal rice. in the viscosity point of view. generally the viscosity related to the addition ratio. The most viscose case was 30% Sangwhang rice but in fermented with monascus ruber rice case, viscosity was low even with 40% case because of the transformation of the starch granules. In sensory evaluation, the highest sensory scores for the uniformity of pore size and flavor were obtained when sangwhang rice flour content was 20%. The textual study was mainly focused on the hardness, cohesiveness, adhesiveness, springiness, chewiness. Textural characteristics of functional rice bread crumb bakedwith 20% coated with soluble dietary fiber rice, 20% sangwhang was low in hardness, chewiness and gumminess. Therefore, Sangwhang rice flour 20%, Monascous ruber 20% and Coated soluble dietary fiber rice 20% were considered to be the most suitable addition ratio for the rice breads.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":136976686,"openaccessinfo":{"externalids":{"MAG":"224813187","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"8-Oxo-7,8-dihydro-2\u2032-deoxyguanosine (8-oxo-dG), a common oxidative DNA lesion, favors a syn-conformation in DNA, enabling formation of stable 8-oxo-dG\u00b7A base mispairs resulting in G\u00b7C \u2192 T\u00b7A transversion mutations. When human DNA polymerase (pol) \u03b2 was used to copy a short single-stranded gap containing a site-directed 8-oxo-dG lesion, incorporation of dAMP opposite 8-oxo-dG was slightly favored over dCMP depending on \"downstream\" sequence context. Unexpectedly, however, a significant increase in dCMP\u00b7A and dGMP\u00b7A mispairs was also observed at the \"upstream\" 3\u2032-template site adjacent to the lesion. Errors at these undamaged template sites occurred in four sequence contexts with both gapped and primed single-stranded DNA templates, but not when pol \u03b1 replaced pol \u03b2. Error rates at sites adjacent to 8-oxo-dG were roughly 1% of the values opposite 8-oxo-dG, potentially generating tandem mutations during in vivo short-gap repair synthesis by pol \u03b2. When 8-oxo-dG was replaced with 8-bromo-2\u2032-deoxyguanosine, incorporation of dCMP was strongly favored by both enzymes, with no detectable misincorporation occurring at neighboring template sites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11183207,"openaccessinfo":{"externalids":{"MAG":"2095149608","ACL":null,"DOI":"10.1074\/jbc.274.22.15920","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/www.jbc.org\/article\/S002192581973107X\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"We consider a ranking regression problem in which we use a dataset of ranked choices to learn Plackett-Luce scores as functions of sample features. We solve the maximum likelihood estimation problem by using the Alternating Directions Method of Multipliers (ADMM), effectively separating the learning of scores and model parameters. This separation allows us to express scores as the stationary distribution of a continuous-time Markov Chain. Using this equivalence, we propose two spectral algorithms for ranking regression that learn model parameters up to 579 times faster than the Newton's method.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":212655877,"openaccessinfo":{"externalids":{"MAG":"3037734441","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examined causal attribution beliefs about breast cancer and the influence that these beliefs exert on health behavior change among breast cancer survivors (BCS). Focus groups with Chinese (n = 21), Korean (n = 11), and Mexican American (n = 9) BCS recruited through community- and hospital-based support groups were conducted. Interviews were audio-recorded, transcribed verbatim, and translated into English for thematic content analysis. Three themes concerning beliefs about breast cancer cause common to all three groups included (a) stress, (b) diet, and (c) fatalism. Causal beliefs corresponded to behavioral changes with women describing efforts to improve their diet and manage their stress. Ethnic minority BCS adhere to beliefs about what caused their cancer that influence their health behaviors. Providing quality health care to ethnically diverse cancer survivors requires cultural sensitivity to patients' beliefs about the causes of their cancer and awareness of how beliefs influence patients' health behaviors post diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32862743,"openaccessinfo":{"externalids":{"MAG":"2110447540","ACL":null,"DOI":"10.1177\/0193945914541518","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc4286528?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"wiring fault is a fault in the fault plane, along with the development of the aviation industry, increasing aging aircraft, how to use the manual fault and failure analysis, mature locomotive repair personnel each should master the basic skills of Boeing aircraft repair. combined with a specific fault, in conjunction with the relevant manuals, carries on the analysis to the wire and remove the fault.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108585820,"openaccessinfo":{"externalids":{"MAG":"1996918270","ACL":null,"DOI":"10.4028\/WWW.SCIENTIFIC.NET\/AMR.971-973.833","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examines the effect of surface currents on the bulk algorithm calculation of wind stress estimated using the scatterometer data during 2007-2020 in the Indian Ocean. In the study region as a whole the wind stress decreased by 5.4% by including currents into the wind stress equation. The most significant reduction in the wind stress is found along the most energetic regions with strong currents such as Somali Current, Equatorial Jets and Aghulhas retroflection. A highest reduction of 11.5% is observed along the equator where the Equatorial Jets prevail. A sensitivity analysis has been carried out for the study region and for different seasons to assess the relative impact of winds and currents in the estimation of wind stress by changing the winds while keeping the currents constants and vice versa. The inclusion of currents decreased the wind stress and this decrease is prominent when the currents are stronger. This study showed that equatorial Indian Ocean is the most sensitive region where the current can impact on wind stress estimation. The results showed that uncertainties in the wind stress estimations are quite large at regional levels and hence better representation of wind stress incorporating ocean currents should be considered in the ocean\/climatic models for accurate air-sea interaction studies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":242044824,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.20944\/preprints202111.0003.v1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.20944\/preprints202111.0003.v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Cross-cultural work environments pose a particular challenge for the organizations that set up and operate a company abroad, especially in terms of job satisfaction, employee retention and motivation. This article aims to investigate cross-cultural interactions between Thai and Chinese people, who work in Thailand in Thai-registered companies, and how cultural differences in working practices affect job satisfaction. It found that in the context of such cross-cultural organizations, cultural differences may not directly affect job satisfaction and commitment, but may aggravate existing organizational problems if cultural differences are not resolved. It proposes a cross-cultural awareness strategy that allows organization to adequately deal with the challenges of cross-cultural interactions in the workplace.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233765647,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.20474\/jabs-3.6.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.20474\/jabs-3.6.1","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Martens, G., Lamari, L., Grieger, A., Gulden, R. H. and McCallum, B. 2014. Comparative yield, disease resistance and response to fungicide for forty-five historic Canadian wheat cultivars. Can. J. Plant Sci. 94: 371-381. Forty-five historic Canadian spring wheat cultivars, ranging from Red Fife (1870) to modern cultivars, were compared for yield and disease resistance in field trials from 2007 to 2010. A split-plot design was used to test yield, leaf rust and Fusarium head blight resistance, with or without a fungicide application. Older cultivars were generally lower yielding and more leaf rust susceptible than modern cultivars; this difference was greatest in 2007 and 2010 under heavier leaf rust. Response to fungicide application was highest in 2007 and 2010. In 2008, leaf rust was very low, and fungicide application had a slightly negative effect on yield overall. Cultivars that have good leaf rust resistance, such as Pasqua, AC Minto, and 5600 HR, had a negligible response to fungicide, whereas older, susceptible cultivars had a larger response. Fusarium head blight levels were too low to compare the cultivars. The highest-yielding cultivars in the untreated plots were AC Domain, 5500HR, AC Cora, Roblin and Barrie, whereas AC Cora, AC Domain, McKenzie, Roblin and AC Intrepid were the highest yielding in the fungicide-treated plots. AC Domain, AC Barrie and Roblin were among the most popular wheat cultivars in Manitoba, in terms of seeded area from the early 1990s to 2009.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90827427,"openaccessinfo":{"externalids":{"MAG":"2596324433","ACL":null,"DOI":"10.1139\/CJPS2013-193","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In cattle fed concentrate diets, rumen amylolytic bacteria digest starch into glucose, which is metabolized for growth. Since metagenomics studies have revealed that uncharacterized ruminal amylolytic bacteria far outnumber known starch utilizers, we have been pursing the identification of novel ruminal amylolytic bacteria. The same Operational Taxonomic Unit (OTU) was enriched independently from the rumen fluid of two beef cows after culturing with starch. Since this identification was performed using the V1\u2013V3 region of the 16S rRNA gene, a metagenomic analysis was conducted to determine whether this OTU represented the same strain or different strains of the same species. A total of 9.25 and 9.16 million sequence reads were respectively generated from a select enriched starch culture from each cow, which had a relative abundance for this OTU of 67.9% and 74.0%, respectively. Contigs were assembled using the publicly available software ABySS, with contigs of at least 2kb in length used for further analysis. Of the enzymes identified by gene annotation of these contigs (using a combination of the online tools RAST and BLASTp), the presence of genes encoding \u03b1-amylase and lactate dehydrogenase enzymes further supported this OTU as corresponding to a starch utilizer. The alpha-amylase isoforms from the two rumens differed in amino acid length (538 vs 625) and sequence, with their respective closest affiliation being to an uncultured species of Lachnospiraceae (51% amino acid identity) and to Prevotella albensis (95% amino acid identity), respectively. The lactate dehydrogenase isoforms were also found to be different in length (348 aa vs 335 aa) and sequence (100% amino acid identity to Lactobacillus mucosae and 99% to an uncultured species of the genus Olsonella, respectively). These and other gene comparisons together suggest that two strains of the same starch-utilizing OTU have been identified in the rumen of beef cows.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":201195275,"openaccessinfo":{"externalids":{"MAG":"2964976533","ACL":null,"DOI":"10.1093\/JAS\/SKZ122.234","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present research work, a hybrid algorithm is introduced, which includes an integral transform \"Sumudu Transform\" and the well-known semi-analytical regime \"Homotopy Perturbation Method\" named as \"Sumudu Transform Homotopy Perturbation Method (STHPM)\" to evaluate the exact solution of Klein-Gordon and Sine-Gordon equations. The discussed equations in this research have a prominent role in sciences and engineering. The authenticity and efficacy of this regime are established via a comparison between approximated solutions and exact solutions. Convergence analysis is also provided, which affirms that the solution obtained from STHPM is convergent and unique in nature. The results obtained by STHPM are compared with exact solutions. 2D and 3D plots are also discussed. The present regime is a reliable technique to provide the exact solution to a wide category of nonlinear PDEs in an easy way, without any need of discretization, complex computation, linearization, and it is also","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":247100886,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.28919\/jmcs\/6979","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.28919\/jmcs\/6979","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Molecular diagnostic tests are the molecular techniques used to detect a nucleic acid of organisms. They have revolutionized the diagnosis of tuberculosis (TB) and drug resistance. Cartridgebased nucleic acid amplification tests (CBNAAT) and line probe assay (LPA) have been accepted in our national tuberculosis control program. CBNAAT has the advantage that it can be done from crude samples and smear negative samples and results can be obtained by 2 hours. But CBNAAT can detect rifampicin resistance only. On the contrary, LPA can detect rifampicin and isoniazid resistance, but the test can only be done at regional or national levels. LPA cannot be done from smear negative or crude specimens. The recent version of LPA (version 2.0) can overcome that problem. Second line LPA can detect the drug resistance against fluoroquinolones, second line injectable drugs and ethambutol (in version 1.0 only). GeneXpert Omni is a portable technique having 4-hour lasting battery using the same cartridge. GeneXpert Ultra has more sensitivity due to larger chamber size and due to two additional probes. Ultra may replace Xpert soon as it will be more effective against smear-negative TB, TB in HIV positive persons, childhood TB, and extrapulmonary TB. With the introduction of molecular diagnostic tests for TB, we will be able to reduce the time of diagnosis of TB and drug resistance. Thereby, we will be able to start first line or second line anti-tubercular chemotherapy earlier, and that will help us to achieve our goal in controlling TB.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2024-18":1,"2024-10":1,"2024-30":1}},"corpusid":203503020,"openaccessinfo":{"externalids":{"MAG":"3005175918","ACL":null,"DOI":"10.5005\/jp-journals-10070-5204","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5005\/jp-journals-10070-5204","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Back Ground: During residency period, doctors all around the globe, experiences stressful working environment and prolonged working hours. These factors leads to lack of concentration, distress and higher level of fatigue; however, residents counter the effects of these extensive, high demanding duty hours by various coping strategies. Although the effects of extended duty hours and various coping strategies used by the doctors have been studied at large. Yet, the difference between the effects & coping styles of trainees of various high demanding specialties' have not been studied. Therefore, this study was carried out to identify and explore the difference in coping strategies for dealing with stress, adopted by post graduate trainees in surgical and non-surgical specialties. Methods: Mixed method approach, with explanatory sequential design was opted for this study. In phase one (quantitative) data was collected by a web based survey; carried out in five teaching hospitals of Rawalpindi & Muzaffarabad in 2020. Data was analysed on SPSS, frequencies and major trends were recorded. An open ended questionnaire was developed on the basis of phase 1 results. In phase two (qualitative), six focus group discussions were carried out with 24 participants to explore the various coping strategies adopted in different situations among the post graduate trainees working in different specialties. Later on, verbatim transcription was done & data analysed manually. Results: Out of 250 (100%) possible participants, 146 (58%) participant responded on-line survey. Where, residents of surgical discipline has a higher response rate (60%, n=87) than non-surgical. Moreover, female participation (54%, n=79) was greater than males (46%, n= 67). Mann-Whitney U test was statistically significant only for seeking medical advice to cope with stress (P= .029). In focus group discussions, female involvement was more (58% n=14) as compare to males (42% n=10). Following themes were developed after data analysis, that is; self-regulation, tailor made strategies, educational focus and support system. Conclusion: Quantitatively, no significant difference was found between the coping strategies of post graduate trainees of surgical & non-surgical trainee, against work related stress. However, minor differences were obtained qualitatively.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":241962715,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-957293\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-957293\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"AN IMPORTANT consideration in regard to standards of care for children with cardiovascular problems is that the pediatricians have the responsibility for organizing a good diagnostic and surgical team. A good anesthesiologist, a competent surgeon, good nursing care, and keen postoperative observation for early signs of complications are all essential to success. The pediatricians cannot regulate the surgeon, but the standards set can require that the surgeons have met their own standards before they have charge of the pediatric surgical program. The superb results of open-heart surgery as quoted by Dr. Kirklin from the Mayo Clinic are unfortunately not a universal experience and hence recommendations for surgery in a given area must be based on local operative results.\n The responsibility for operation rests clearly with the pediatrician and the pediatric cardiologist. The family grants permission for operation but their consent is given on the basis of the advice they receive from the doctor. If operation is not indicated or the risk too high, ours is the responsibility to persuade child and parent not to have an operation. To do right by the child and the family the diagnosis should be accurate, the indications for surgery should be clear, and the family should fully understand the situation. Even if the odds are overwhelmingly in favor of a successful operation, for any one patient the odds are one to one between life and death.\n Cardiac operations should be undertaken only to correct or alleviate an abnormality of the heart. Indeed, the pediatrician must be certain that the child's complaints are related to the cardiac condition. The tendency is a natural one to assume that two unknowns go together.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":10519874,"openaccessinfo":{"externalids":{"MAG":"1906855504","ACL":null,"DOI":"10.1542\/peds.33.6.997","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The fault-slip type of rock burst is a major threat to the safety of coal mining, and effectively recognizing its signals patterns is the foundation for the early warning and prevention. At first, a mechanical model of the fault-slip was established and the mechanism of the rock burst induced by the fault-slip was revealed. Then, the patterns of the electromagnetic radiation, acoustic emission (AE), and microseismic signals in the fault-slip type of rock burst were proposed, in that before the rock burst occurs, the electromagnetic radiation intensity near the sliding surface increases rapidly, the AE energy rises exponentially, and the energy released by microseismic events experiences at least one peak and is close to the next peak. At last, in situ investigations were performed at number 1412 coal face in the Huafeng Mine, China. Results showed that the signals patterns proposed are in good agreement with the process of the fault-slip type of rock burst. The pattern recognition can provide a basis for the early warning and the implementation of relief measures of the fault-slip type of rock burst.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73593985,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bottom-up collaboration between scientists across borders is expanding, as shown by authorship analyses. It is also fruitful, since publications with authors from several countries have, on the average, higher impact than single-country papers. Coordinated international collaboration is needed to address complex problems in a strategic and interdisciplinary fashion. The International Council for Science (ICSU) organized the International Geophysical Year in 1957, which fostered research in global environmental change from the geosciences perspective. The scope of research interest soon expanded, first into other \"hard\" natural sciences, then into biological and ecological sciences, and finally into social sciences. To coordinate international research, ICSU with partners set up four interdisciplinary programs, with the focus first on climate (WCRP), then on the geosphere-biosphere (IGBP), ecology and biodiversity (Diversitas), and finally the the human dimension (IHDP). These programs produced most of the science reviewed by the IPCC in its assessments and advice to policymakers","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":135031998,"openaccessinfo":{"externalids":{"MAG":"2714099582","ACL":null,"DOI":"10.4316\/GEOREVIEW.2016.0.0.346","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Studies of canalicular bile secretion have been limited due to lack of direct access to the canalicular lumen. Isolated rat hepatocyte couplets, consisting of two hepatocytes enclosing a canalicular space, have been proposed as a primary secretory unit that may be useful for direct studies of unmodified canalicular bile secretion. The present study examines their structural characteristics and plasma membrane reorganization. The canalicular space of freshly isolated hepatocyte couplets is freely permeable to ruthenium red, but within 4 hr the junctional borders reseal in most couplets which then exclude ruthenium red from the luminal area. These resealed spaces expand in 61.8 \u00b1 10% of couplets as secretion is elaborated and after 4 hr in monolayer culture, 12.7 \u00b1 4.7% of the canalicular spaces are dilated to diameters greater than 3 \u03bc. Normal\u2010appearing microvilli line these canalicular membranes in the majority of dilated spaces as assessed by electron microscopy. Immediately after isolation, Mg++\u2010ATPase, a histochemical marker for canalicular membranes, is located as a discrete band corresponding to the normal in vivo circumferential distribution of the canalicular membrane domain. However, this pattern of Mg++\u2010ATP\u2010ase staining rapidly diminishes and reorganizes at the remaining canalicular pole within several hours. This membrane reorganization is a microfilament\u2010dependent process, since it is inhibited by cytochalasin D but not by colchicine, an inhibitor of microtubular function or cycloheximide, an inhibitor of new protein synthesis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26013679,"openaccessinfo":{"externalids":{"MAG":"2039735355","ACL":null,"DOI":"10.1002\/hep.1840070203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The present paper discusses the relevance of silver-stained Nucleolar Organizer Regions (AgNOR) to tumour pathology. First, the structural and functional aspects of AgNORs and the biological meaning of their quantitative variations have been reviewed to clearly define which indications can be obtained by the use of AgNOR. In continuously proliferating cells, AgNOR indicates the extent of ribosomal biogenesis, which is strictly related to the rapidity of cell proliferation. Therefore, AgNOR can be considered to represent a marker of cell proliferation rate and, in tumour pathology, should be used only for prognostic purposes. The predictive value of AgNOR, the only parameter which indicates the cell growth rate in situ in routinely processed cyto-histological samples, is strengthened by the combination with markers of cell growth kinetics (e.g. Ki67\/MIB1).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21107653,"openaccessinfo":{"externalids":{"MAG":"19742365","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The second Born approximation (SBA) theory is applied to the study of electron-atom scattering in the presence of a CO2 laser field.The absolute differential cross sections of e-Ar scattering are calculated with multiphoton exchange in two special scattering geometries G1 (for small-angle scattering) and G2. For geometry G1, compared with the results of two different model potentials for electron elastic scattering by atoms, it is found that electron-atom polarization potential plays an important role in laser-assisted electron-atom scattering. Some calculational results in geometries G2 are given. Our results are found to be better than other theoretical results as compared with the experimental data in geometries G1 and G2.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":124011374,"openaccessinfo":{"externalids":{"MAG":"2332860970","ACL":null,"DOI":"10.1088\/0253-6102\/51\/1\/25","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The advent of super-resolution microscopy has opened up new avenues to unveil brain structures with unprecedented spatial resolution in the living state. Yet, its application to live animals remains a genuine challenge. Getting optical access to the brain in vivo requires the use of a 'cranial window', whose mounting greatly influences image quality. Indeed, the coverslip used for the cranial window should lie as orthogonal as possible to the optical axis of the objective, or else significant optical aberrations occur. In this work, we assess the effect of the tilt angle of the coverslip on STED and two-photon microscopy, in particular image brightness and spatial resolution. We then propose an approach to measure and reduce the tilt using a simple device added to the microscope, which can ensure orthogonality with a precision of 0.07\u00b0.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1}},"corpusid":264935892,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2023.10.26.564142","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2023\/10\/31\/2023.10.26.564142.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Recent progress in understanding kinetics of texturing during structural phase transitions with long-range strain interactions is reviewed. We analyse systems with elastically mediated interaction which due to its anisotropy and infinite range has a pronounced effect on kinetics and textures occurring during the phase transition. As a generic example the textures ('stripe' and 'tweed' phases) due to oxygen ordering in layered high-Tc cuprates (YBCO) are discussed. An atomic ordering process in cell i generates a local stress field, which is propagated elastically to a distant cell j.The effective elastic interaction J(Rij) at large distances can be broken into a highly anisotropic spatial part, defining a few 'soft' directions coinciding with the orientation of twin boundaries, and the so-called Zener interaction Jz of infinite range. The spatial part of the interaction falls off oc 1\/R3ij in ferroelastic and oc 1\/R5ij in anti-ferroelastic materials, with corresponding differences of the properties of domain walls in these two cases. We analyse the origin of tweed texture usually seen when a ferroelastic material is quenched through the transition temperature Tc, and under other conditions. It is argued that a dense mass of embryos of the ordered phase is present as thermodynamic fluctuations at temperatures well above Tc. These fluctuations control the length and width of the tweed microdomains observed after quenching. Further coarsening of the tweed towards a stripe texture proceeds via the creation of needle domains governed by the strains around right-angled domain walls. Unusual texture formation under sudden heating is discussed.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119916165,"openaccessinfo":{"externalids":{"MAG":"3046589421","ACL":null,"DOI":"10.1098\/rsta.1996.0133","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A model of one dimensional in position and three dimensional in velocity space self-consistent particle in cell with Monte Carlo collision technique was employed to simulate the argon discharge between the needle and plane electrodes at high pressure, in which a nanosecond rectangular pulse was applied to the needle electrode. The work focused on the investigation of the spatiotemporal evolution of the discharge versus the needle tip size and working gas pressure. The simulation results showed that the discharge occurred mainly in the region near the needle tip at atmospheric pressure, and that the small radius of the needle tip led to easy discharge. Reducing the gas pressure gave rise to a transition from a corona discharge to a glowlike discharge along the needle-to-plane direction. The microscopic mechanism for the transition can arguably be attributed to the peak of high-energy electrons occurring before the breakdown; the magnitude of the number of these electrons determined whether the breakdown can take place.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":122891920,"openaccessinfo":{"externalids":{"MAG":"2078929244","ACL":null,"DOI":"10.1063\/1.3082111","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/pubs.aip.org\/aip\/jap\/article-pdf\/doi\/10.1063\/1.3082111\/15029014\/043305_1_online.pdf","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The current educational context is facing new educational challenges due to the worldwide proliferation of Covid-19. For this reason, it was necessary to generate a digital literacy oriented from a creative and innovative perspective, in this regard it was decided to apply the Maker methodological style, to high school students from the Arequipa region in Peru. Likewise, considering that education is being developed in homes under the E-learning modality, it was necessary to stimulate invisible learning, because its application offers many possibilities to develop skills, abilities, capacities, competencies that are not formally established in the curriculum and that are necessary for life; starting from learning by doing, promoting creativity and taking the context into consideration. The main objective of this study was to analyze the appropriation of the Maker methodology in the educational field to determine the impact it may have. The applied research methodology was mixed, and a survey was applied to 350 students, of both sexes, at the secondary level, whose ages are between 14 and 17 years old. This research study allowed to conclude that the Maker methodology, applied in times of pandemic, is effective to improve the learning and motivational level of students starting from learning by doing, experimenting, playing, creating, researching, and innovating, where the initiative and strengths of the students they are the driving forces for this development.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":247320558,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/LACLO54177.2021.00045","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Corcyra cephalonica is a menace to agricultural crop produces infesting cereals, and many other food products, hence an attempt was made to control the stored products pest by using medicinal plant extract Vitex negundo. The protein content in the fat body increased gradually in the larvae, pupae and the adults of Corcyra cephalonica, whereas in the Vitex negundo treated resultant larvae there was a prominent decrease in the protein content when compared with the controls.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":86022553,"openaccessinfo":{"externalids":{"MAG":"2181864002","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nThe measurement of hemoglobin concentration ([Hb]) is performed routinely as a part of a complete blood cell count to evaluate the oxygen-carrying capacity of blood. Devices currently available to physicians and clinical laboratories for measuring [Hb] are accurate, operate on small samples, and provide results rapidly, but may be prohibitively expensive for resource-limited settings. The unavailability of accurate but inexpensive diagnostic tools often precludes proper diagnosis of anemia in low-income developing countries. Therefore, we developed a simple paper-based assay for measuring [Hb].\n\n\nMETHODS\nA 20-\u03bcL droplet of a mixture of blood and Drabkin reagent was deposited onto patterned chromatography paper. The resulting blood stain was digitized with a portable scanner and analyzed. The mean color intensity of the blood stain was used to quantify [Hb]. We compared the performance of the paper-based Hb assay with a hematology analyzer (comparison method) using blood samples from 54 subjects.\n\n\nRESULTS\nThe values of [Hb] measured by the paper-based assay and the comparison method were highly correlated (R(2) = 0.9598); the standard deviation of the difference between the two measurements was 0.62 g\/dL. The assay was accurate within 1 g\/dL 90.7% of the time, overestimating [Hb] by \u22651 g\/dL in 1.9% and underestimating [Hb] by \u22651 g\/dL in 7.4% of the subjects.\n\n\nCONCLUSIONS\nThis study demonstrates the feasibility of the paper-based Hb assay. This simple, low-cost test should be useful for diagnosing anemia in resource-limited settings, particularly in the context of care for malaria, HIV, and sickle cell disease patients in sub-Saharan Africa.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14091623,"openaccessinfo":{"externalids":{"MAG":"2135052317","ACL":null,"DOI":"10.1373\/clinchem.2013.204701","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/clinchem.aaccjnls.org\/content\/clinchem\/59\/10\/1506.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The influence of boiling water treatment on the surface roughness and surface microstructure of set gypsums was investigated. Typical surfaces before and after immersion in boiling water were compared by means of SEM observation, the Knoop hardness test, and a surface roughness test. The surfaces of set gypsums were rougher than that of an acrylic resin plate, and after immersion in boiling water, highly roughened surfaces and thinner crystal bodies were observed on each specimen under SEM. The knoop hardness of set gypsums was considerably lowered after boiling water immersion. That of die stones was the same or lower than set dental stones. The results showed that even brief immersion in boiling water had profound effects on the dental stone cast, resulting in rougher surfaces and lower hardness of set gypsums.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1813015,"openaccessinfo":{"externalids":{"MAG":"2326752945","ACL":null,"DOI":"10.4012\/DMJ.14.245","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper highlights the effects of pouring temperature and holding time on the mechanical properties of aluminium 6061 semisolid feedstock billets. The semisolid metal feedstock billets were prepared by a direct thermal method (DTM), in which the molten metal was poured into a cylindrical copper mould with a different combination of pouring temperature and holding time before it was solidified in room temperature water. The results show that the sample with pouring temperature slightly above aluminium 6061 liquidus temperature has the lowest porosity, thereby the highest mechanical properties value. The sample with a pouring temperature of 660 \u00b0C and holding time of 60 s has the density, tensile strength and hardness properties of 2.701 g\/cm3, 146.797 MPa, and 86.5 HV, respectively. Meanwhile, the sample at a pouring temperature of 640 \u00b0C and holding time of 20 s has density, tensile strength and hardness properties of 2.527 g\/cm3, 65.39 MPa, and 71.79 HV, respectively. The density and fractography tests were conducted to confirm the existence of porosity within the samples. The results from these experimental works suggested that the mechanical properties of DTM semisolid feedstock billet merely depended on processing parameters, which influenced the porosity level within the feedstock billet, thus directly affected their mechanical properties.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":233437565,"openaccessinfo":{"externalids":{"MAG":"3147092910","ACL":null,"DOI":"10.15282\/IJAME.18.1.2021.17.0652","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This is an informative read for any nurse or student training in the mental health field. It includes more than 70 conditions from anxiety to schizophrenia, as well as the range of treatment options. It also looks at nursing concepts in mental health and subjects such as communication, consent, multidisciplinary care, advocacy and scope of practice. There are expert tips on patient care, research, cultural considerations and the latest news in psychopharmacology.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":74842726,"openaccessinfo":{"externalids":{"MAG":"2507333763","ACL":null,"DOI":"10.7748\/ns.24.49.30.s37","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There is a growing demand for accurate high-resolution land cover maps in many fields, e.g., in land-use planning and biodiversity conservation. Developing such maps has been performed using Object-Based Image Analysis (OBIA) methods, which usually reach good accuracies, but require a high human supervision and the best configuration for one image can hardly be extrapolated to a different image. Recently, the deep learning Convolutional Neural Networks (CNNs) have shown outstanding results in object recognition in the field of computer vision. However, they have not been fully explored yet in land cover mapping for detecting species of high biodiversity conservation interest. This paper analyzes the potential of CNNs-based methods for plant species detection using free high-resolution Google Earth T M images and provides an objective comparison with the state-of-the-art OBIA-methods. We consider as case study the detection of Ziziphus lotus shrubs, which are protected as a priority habitat under the European Union Habitats Directive. According to our results, compared to OBIA-based methods, the proposed CNN-based detection model, in combination with data-augmentation, transfer learning and pre-processing, achieves higher performance with less human intervention and the knowledge it acquires in the first image can be transferred to other images, which makes the detection process very fast. The provided methodology can be systematically reproduced for other species detection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46110140,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1706.00917"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lercanidipine is a BCS Class II drug having poor aqueous solubility and good permeability through the plasma membranes. Absolute bioavailability of the drug is only 10% and the main reason attributed for such a low bioavailability is poor aqueous solubility of the drug. Different methods have been tried to enhance the solubility of the drug but most of them have not been found satisfactory due to either less enhancement of solubility or limited industrial application. Liquisolid technology is one of the most promising techniques to enhance the aqueous solubility. In the present study the drug was screened with three non-volatile liquid vehicles namely PEG 400, Polysorbate 80 (Tween 80) and Propylene glycol (PG). The best result was obtained with PEG 400 because of the highest solubility of the drug in PEG 400 amongst the non-volatile liquid vehicles. Hence optimization of the formula was done taking PEG 400 to achieve 100% drug release. Avicel PH 102 and Aerosil 200 were used as carrier and coating material correspondingly. The In-vitro dissolution test was carried out with USP Type II (paddle) apparatus taking phosphate buffer (pH 6.8) as dissolution medium. The compatibility of the formulation was checked by FT-IR study. The improved wetting property and increased surface area (molecular dispersion) are believed mechanisms for enhancement of the solubility of lercanidipine. The method of production of liquisolid compact is very easy and there is no use of highly developed equipment, which makes this technology industrially applicable.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":201111174,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this letter, a silicon-embedded receiving coil is designed and fabricated for high-efficiency wireless power transfer to implantable biomedical ICs. The 4.5 mm \u00d7 4.5 mm embedded receiving coil achieved a large inductance of 4 \u03bcH and a high peak quality factor of 20 at 2.8 MHz. Measurement results of an inductive power link using the embedded receiving coil and a conventional printed-circuit-board transmitting coil (2 cm \u00d7 2 cm) demonstrated peak voltage gains of 0.84 and 0.24 and peak efficiency values of 30% and 4.3% for separation distances of 5 and 12 mm, respectively. This is the best reported wireless power transmission efficiency for separation distance similar to the implant chip size.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":33153148,"openaccessinfo":{"externalids":{"MAG":"2020641364","ACL":null,"DOI":"10.1109\/LED.2012.2225135","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Intergenerational associations in chronic obstructive pulmonary disease (COPD) have been well recognized and may result from genetic, gene environment, or exposure to life course factors. Consequently, adult offspring of parents with COPD may be at a greater risk of developing COPD. The aim of this study was to review the prevalence of co-occurrence of COPD in adult offspring with one or both parents having COPD independent of specific genetic variations. Methods In total, five databases were searched for original studies in which prevalence of COPD was reported in both offspring (children) and one or both parents. Studies were excluded if COPD was not clearly defined, COPD was linked to specific genetic variations, COPD was combined with other chronic respiratory conditions, or estimates included other first-degree relatives. Data extraction (ie, sample characteristics, prevalence of COPD, and odds ratio [OR] if reported) was completed by two independent reviewers. A meta-analysis of prevalence and OR was conducted, where possible. Results Of the 3,382 citations, 129 full texts were reviewed to include eight studies (six case\u2013control, one cross-sectional, and one cohort) reflecting either prevalence of COPD in offspring of parents with COPD (descendent approach, n=3), which ranged from 0% to 17.3%, or prevalence of people with COPD reporting positive parental history of COPD (antecedent approach, n=5), for which the pooled prevalence was 28.6%. Offspring of people with COPD had 1.57 times greater odds (95% confidence interval =1.29\u20131.93; P<0.001) of having COPD compared with people not having a parental history of COPD. Conclusion The prevalence of COPD in adult offspring of people with COPD is greater than population-based estimates, and the ORs indicate a higher risk in this group. This offers clinicians a potential strategy for opportunistic screening, early identification, and intervention in this at-risk group.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":9177423,"openaccessinfo":{"externalids":{"MAG":"2581486274","ACL":null,"DOI":"10.2147\/COPD.S123933","PubMedCentral":"5279828","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Delusional misidentification syndrome is a less common neuropsychiatric symptom and can occur in different diseases as dementia and psychiatric diseases or as part of a somatic disease. It can be difficult to recognise and can give a high burden for the formal caregiver. In this article we describe three cases, the pathophysiology and the possible treatment of a delusional misidentification syndrome.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248494131,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The hadronic decay B \u2192 J\/\u03c8K\u2217 is analyzed within the framework of QCD factorization. The spin amplitudes A0, A\u2016 and A\u22a5 in the transversity basis and their relative phases are studied using various different form-factor models for B \u2212K\u2217 transition. The effective parameters a2 for helicity h = 0,+,\u2212 states receive different nonfactorizable contributions and hence they are helicity dependent, contrary to naive factorization where a2 are universal and polarization independent. QCD factorization breaks down even at the twist-2 level for transverse hard spectator interactions. Although a nontrivial strong phase for the A\u2016 amplitude can be achieved by adjusting the phase of an infrared divergent contribution, the present QCD factorization calculation cannot say anything definite about the phase \u03c6\u2016. Unlike B \u2192 J\/\u03c8K decays, the longitudinal parameter a2 for B \u2192 J\/\u03c8K\u2217 does not receive twist-3 corrections and is not large enough to account for the observed branching ratio and the fraction of longitudinal polarization. Possible enhancement mechanisms for a2 are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15707587,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In 2008, Sweden introduced a cash-for-care benefit consisting of a flat-rate sum paid by municipalities to parents of children between the ages of one and three who did not use publicly subsidized childcare. The main object of the reform was to increase parents? ?freedom to choose?, but the policy was criticized because of its potentially negative effects on gender equality and mothers? employment. This study focuses on the effects of cash-for-care on female employment in Sweden. The study shows that the adoption of this policy had negative effects on female employment rates and female employment growth rates in non-urban areas. Cash-for-care was abolished in Sweden in 2016, but similar policies are still in place in other Scandinavian countries. This research contributes to the debate on family policy and its developments, in particular in Scandinavian countries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":157825352,"openaccessinfo":{"externalids":{"MAG":"2570478572","ACL":null,"DOI":"10.20472\/iac.2016.025.026","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/iises.net\/proceedings\/25th-international-academic-conference-oecd-paris\/table-of-content?cid=41&iid=026&rid=6714","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The study focuses on the causes of discrepancies at the design and construction interface. The subject is treated in two parts. The first part covers a review of literature discussing the subject of design construction interface issues. The review which includes major periodicals, research reports, and some text books, is summarized into four parts; definition of interface, construction, the cost and pricing aspects, and the management and administration of change orders. The information and recommendations made in this part were used to develop and establish direction for the second part of the study. Initially pilot study was carried out based on survey questionnaire developed through literature review. Pilot study encircles three large building projects, eventually the validity of tentative questionnaire was evaluated and final questionnaire for survey at macro perspective was organized. Responses from (31) thirty one consultants and thirty contractors were analyzed through statistical analysis tool, the results indicate that lack of coordination, insufficient working drawing details, involvement of designer as consultant, involvement of contractor as consultant and participants' honest wrong beliefs are considered as most important origins of professional dissonances on project design and construction interfaces. Whereas, the project management as individual professional service, nationality of professional firms and involvement of contractor in design phases are interestingly revealed as least important origins of dissonances between professionals on project design and construction interfaces in large building projects. The cause and effect diagram which is represented as part of research work helps to pin point the root cause of the problem of design construction interface issues.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212481928,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The text discusses the growing incidence of autism in the world, presents an understanding of autism from the point of view of analytical psychology, and reflects on the treatment of autistic patients. Today, it is understood that autism is part of a continuum of characteristics on a spectrum with biological and congenital causes. It is a non-specific picture resulting from multiple causations of non-linear factors. Autism is a neuro-developmental disorder characterized by a triad of symptoms: persistent deficits in social communication and social interaction, and restricted and repetitive patterns of behaviours, interests, or activities. Autism spectrum disorder must be considered as a clinical entity, with current clearly defined characteristics. It is an extremely complex condition, which requires multidisciplinary approaches aiming at the possibility of prognosis and effective therapeutic approaches. This paper explores how a disturbance may occur from the intra-uterine phase, in which matriarchal experiences do not constellate. The structuring function of the patriarchal organization can then become dominant, and people with autism need understanding and help to organize their world and learn to live in it. As they don't have the capacity to structure consciousness through the matriarchal archetype, they rely entirely on the structuring and organizing capacity of the Father archetype.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248156734,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/1468-5922.12746","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sensation seeking has been associated with substance use and other risk\u2010taking behaviors. The present functional magnetic resonance imaging (fMRI) study investigated the neural correlates underlying risk taking in sensation seeking. Twenty\u2010eight high sensation seekers (HSS; 14 female and 14 male young adults) and 28 low sensation seekers (LSS; 14 female and 14 male young adults) performed an interactive, sequential gambling task that allowed for voluntary pursuit or inhibition of risk taking. Behaviorally, HSS versus LSS exhibited a stronger tendency toward risk taking. Comparison of the groups revealed that when taking risks, HSS relative to LSS exhibited reduced fMRI responses in brain areas involved in risk processing, such as the dorsomedial prefrontal cortex and the thalamus. Importantly, during the voluntary inhibition of risk taking, HSS relative to LSS showed greater fMRI responses in brain areas implicated in cognitive control (the bilateral anterior cingulate cortex) and negative emotion (the right anterior insula). These findings suggest that risk taking in sensation seeking may be driven by both a hypoactive neural system in the voluntary pursuit of risk taking and a hyperactive neural system in the voluntary inhibition of risk taking, thus providing implications for future prevention programs targeting sensation\u2010seeking behaviors. Hum Brain Mapp 38:6019\u20136028, 2017. \u00a9 2017 Wiley Periodicals, Inc.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37406302,"openaccessinfo":{"externalids":{"MAG":"2752100912","ACL":null,"DOI":"10.1002\/hbm.23807","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/hbm.23807","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Data from the deformation on Split-Hopkinson Bar were used for constructing an artificial neural network model. When putting the thermodynamic parameters of the metals into the trained network model, the corresponding yielding stress can be predicted. The results show that the systematic error is small when the objective function is 0.5, the number of the nodes in the hidden layer is 6 and the learning rate is about 0.1, and the accuracy of the rate-error is less than 3%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":106498607,"openaccessinfo":{"externalids":{"MAG":"958394507","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The fact that children have not been supposed to be very susceptible to typhoid fever, and, when affected, are apt to exhibit an irregular type of the disease, would seem to render a study of cases of value for future comparison and reference. It is during an epidemic that they are most liable to be attacked, so that such an occasion affords the most favorable opportunity for a study of any peculiarities the disease may show in early life. Since the employment of Widal's test, the field has widened by proving that typhoid fever in certain mild types may be overlooked in children or mistaken for some other affection. During the fall of 1913, an epidemic of typhoid fever occurred in the lower East side of New York, including 521 reported cases, with a mortality of 11.7 per cent. Many children were attacked as shown by the following reported number","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":72631749,"openaccessinfo":{"externalids":{"MAG":"2086709292","ACL":null,"DOI":"10.1001\/archpedi.1914.04300010136004","PubMedCentral":null,"ArXiv":null},"license":"public-domain","url":"https:\/\/zenodo.org\/record\/1500205\/files\/article.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The strong non-deterministic polynomial-hard( NP-hard)character of job shop scheduling problem( JSSP) has been acknowledged widely and it becomes stronger when attaches the nowait constraint,which widely exists in many production processes,such as chemistry process, metallurgical process. However,compared with the massive research on traditional job shop problem,little attention has been paid on the no-wait constraint.Therefore,in this paper, we have dealt with this problem by decomposing it into two sub-problems, the timetabling and sequencing problems,in traditional frame work. A new efficient combined non-order timetabling method,coordinated with objective of total tardiness,is proposed for the timetabling problems. As for the sequencing one,we have presented a modified complete local search with memory combined by crossover operator and distance counting. The entire algorithm was tested on well-known benchmark problems and compared with several existing algorithms.Computational experiments showed that our proposed algorithm performed both effectively and efficiently.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":117742199,"openaccessinfo":{"externalids":{"MAG":"830758479","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examines how financial statement management via pension plan assumption choices, a simple mechanism through which management can manipulate financial reports, is related to corporate governance effectiveness. Based on our sample of Taiwanese listed companies, which are characterized by a high degree of ownership concentration and an emerging economy, we find that the deviation between control rights and cash flow rights, the number of board seats held by the ultimate controller, and board independence are significantly related to more aggressive expected rate of return on pension assets assumption choices. We also find that when the ultimate controller also serves as the CEO, this conflict of interest is associated with aggressive pension assumptions related to the PBO. In addition, institutional shareholders appear to play an important monitoring role, which can mitigate opportunistic pension rate assumption choices. Our findings indicate that the opacity inherent in pension accounting guidance is likely exacerbated by poor corporate governance. It informs the current debate over measurement and reporting discretion for DB pension plans specifically as well as the more general debate over managing financial statements in the presence of accounting discretion.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":166377315,"openaccessinfo":{"externalids":{"MAG":"1518968673","ACL":null,"DOI":"10.2139\/ssrn.2236344","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Recombination in mouse cells was analyzed using extrachromosomal DNA substrates carrying the mouse immunoglobulin switch regions S mu and S gamma 2b. Recombination was detected at a frequency of 10(-2)-10(-3) in mouse fibroblasts and in pre-B cell lines, but at a low frequency in a scid fibroblast cell line. Restriction enzyme digestion profile revealed that most recombination occurred between the CMV promoter region, which neighbors the S mu upstream region, and the S gamma 2b region. However, frequency of direct recombination between the CMV promoter region and the S gamma 2b region was low as measured by the substrate-lacking S mu region. Nucleotide sequence analysis showed that recombination occurred between several homologous base-pairs, and extranucleotides were frequently found at the recombination junctions. These results indicate that recombination took the form of the recombination mediated by double-strand breaks. Double-strand breaks likely occurred in the S mu and\/or S gamma 2b region, and the ends joined.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24445187,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Type-2 defuzzification is a two-stage process. Type-reduction, the first stage, gives rise to a type-1 fuzzy set known as the type-reduced set (TRS), which for the second stage is defuzzified to give a crisp number. This paper focusses on the TRS itself, which reveals a fascinating internal structure. We provide a description of and explanation for this structure, then go on to suggest how it may be exploited to enable the application of the Karnik-Mendel Iterative Procedure to generalised type-2 fuzzy sets.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-26":1,"unknown":2}},"corpusid":82861,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The Journal of Palestine Studies' special issue on infrastructure, environment, and health in Palestine sheds new light on the conditions and possibilities of politics. Although it is commonly viewed as \"an entity ostensibly separate from technology and other human constructions,\" the environment is in fact a particular configuration of \"socio-technical arrangements.\" The special issue's four articles and two reflection essays\u2014by Nadi Abusaada, Leena Dallasheh, Samir Harb, Cristina Violante, Nimrod Ben Zeev, and Emily McKee\u2014span historical periods from Ottoman-ruled Palestine to the contemporary era. Hailing from the fields of history, architecture, anthropology, and legal theory, the contributors draw on original archival, spatial, and ethnographic research to parse the realities, experiences, and lessons that Palestine offers beyond its status as a site of settler-colonial deprivation and toxicity. Together they demonstrate that infrastructure, environment, and health are fundamentally and irrefutably political.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":253459454,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/0377919X.2022.2126202","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Different substrates which activate the enzyme synthesis were added to the natural medium for Asp. terreus 17P cultivation where wheat straw was used as the carbon source. Tween-80, oleic acid, sodium salts of ascorbic and acetic acid, potassium salt of indolyl acetic acid, sunflower seed oil, coreander seed oil, soapstock and sugars--glucose, sucrose, fructose and lactose were tested. An addition of Tween-80 at a concentration of 0.1% to the cultivation medium showed the most favourable effect on the synthesis of cellulolytic enzymes. Milk serum and cheese serum, malt shoots and protein-vitamin complex were examined as a substitute for corn extract. Dry malt shoots added at a concentration of 1.5% was a good substitute for corn extract.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88614531,"openaccessinfo":{"externalids":{"MAG":"2410346612","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Research into reading difficulties in Russian has been taking place for about a century, since the 1920s. Early research established a line of studies on reading acquisition difficulties in the context of highly structured practices of teaching reading. These practices were propagated in the mid-late 19th century by Konstantin Ushinskii, who designed a mass system for the directed teaching of reading in Russian based on the mastery of spoken Russian (namely its phonics, phonology, orthography, and morphology). During the Soviet period, this approach was packaged in a universal system that included programs for children and adults, and appears to have been responsible for the high literacy rates (i.e., near 100%) at the end of the last century. In the 1990s, an explosion of diverse reading programs surfaced, claiming to offer a contrast to the Ushinskii system's universal but \"boring\" content. Nevertheless, the Ushinskii system regained popularity in the early years of the 21st century. Reincarnated and modernized, it once again constitutes the foundation of reading instruction in Russian schools. This article investigates the distribution of various reading-related skills among Russian primary-school students (Grades 2\u20134) in the context of this universally strong approach to teaching reading.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":225122970,"openaccessinfo":{"externalids":{"MAG":"3091920931","ACL":null,"DOI":"10.1177\/0731948720963664","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The spatial distribution of corticolous lichens on the iconic New Zealand p\u014dhutukawa (Metrosideros excelsa) tree was investigated from a survey of urban parks and forests across the city of Auckland in the North Island of New Zealand. Lichens were identified from ten randomly selected trees at 20 sampling sites, with 10 sites classified as coastal and another 10 as inland sites. Lichen data were correlated with distance from sea, distance from major roads, distance from native forests, mean tree DBH (diameter at breast height) and the seven-year average of measured NO2 over the area. A total of 33 lichen species were found with coastal sites harboring significantly higher average lichen species per tree as well as higher site species richness. We found mild hotspots in two sites for average lichen species per tree and another two separate sites for species richness, with all hotspots at the coast. A positive correlation between lichen species richness and DBH was found. Sites in coastal locations were more similar to each other in terms of lichen community composition than they were to adjacent inland sites and some species were only found at coastal sites. The average number of lichen species per tree was negatively correlated with distance from the coast, suggesting that the characteristic lichen flora found on p\u014dhutukawa may be reliant on coastal microclimates. There were no correlations with distance from major roads, and a slight positive correlation between NO2 levels and average lichen species per tree.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":233735342,"openaccessinfo":{"externalids":{"MAG":"3155099104","ACL":null,"DOI":"10.3390\/D13040170","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES: This study was carried out to evaluate homocysteine as a risk factor for ischemic \nstroke. \nDESIGN: Descriptive study \nSETTING: Isra University & Liaquat university of Medical and health sciences Jamshoro \n(LUMHS). \nSTUDY DESIGN: Twenty five diagnosed cases of ischemic stroke were selected from different \nwards of two hospitals. Twenty five healthy age matched persons were taken as controls having \nno risk factors for stroke. Serum homocysteine level was determined by enzyme immunoassay \nusing commercially available kit. \nRESULTS: Serum homocysteine level in patients with stroke was 14.0 + 1.9 \u03bcmol\/Lit and in \nhealthy controls it was 9.0 + 0.58 \u03bcmol\/Lit. There was statically significant difference (p < 0.05) \nin the homocysteine level between the two groups yet the level was within normal range. \nCONCLUSION: Serum homocysteine level is significantly increased in patients with ischemic \nstroke as compared to the normal healthy individuals having no ischemic stroke risk factors.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":74448372,"openaccessinfo":{"externalids":{"MAG":"2181939500","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Counts are non-negative integers. It represents the number of occurrences of an event within a fixed period. Measurements scales of categorical variable consist of two main types of measurement scales, ordered scales that named ordinal variables and unordered scales that named nominal variables. Regression models are the most frequently used statistical models for analyzing count data such as Poisson and negative binomial regression models; logistic regression models are used with binary and categorical variables. The main goals of this research are considering these models along estimating the parameters of them, discuss the proper model of each type of data, and make a comparison between models using suitable statistical programs for analyzing the two data sets.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256973088,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.53555\/eijms.v5i1.40","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"http:\/\/eijms.com\/index.php\/ms\/article\/download\/40\/90","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"In this study, we consider the problem of speaker recognition in a non-stationary room\/channel mismatched condition. In such circumstances, cepstral coefficients are affected in a way that the short-term stationarity assumption, on which conventional feature normalization methods are based on, may not be valid. We observe that the empirical mode decomposition (EMD) applied to the cepstral feature stream can partially separate out the non-stationary channel components, if present, into its residual signal and other lower order intrinsic mode functions (IMFs), which leads us to develop a filtering scheme based on this decomposition. The proposed method works in the time domain making use of the instantaneous frequency function obtained through Hilbert spectral analysis of the IMFs. Experimental evaluations on the TIMIT database with added non-stationary room channels in test demonstrate the superiority of the proposed scheme compared to conventional feature normalization schemes. Additional experiments performed on the newly released noisy robust open set speaker identification (ROSSI) and NIST SRE corpora also confirm the effectiveness of the proposed method in stationary room\/channel mismatched conditions. Index Terms: Speaker verification, non-stationary room channel, empirical mode decomposition","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":18514427,"openaccessinfo":{"externalids":{"MAG":"2296031562","ACL":null,"DOI":"10.21437\/Interspeech.2011-150","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"NSF, NIH and other funding agencies are now requiring Data Management Plans that include the expectation of sharing research data. To facilitate this expectation, librarians from the University of Houston are developing an automated online system to document data sets at the various stages of their life cycle. Our process will consist of determining key Dublin Core elements and developing a discipline-specific crosswalk. (This crosswalk translates discipline-specific terminology to that used by Dublin Core.) The discipline-specific terminology and the key element set will be developed in collaboration with faculty researchers. This set will be minimal in order to reduce the burden to the researcher in documenting their data yet provide enough information for the management of the data over its life cycle. Ultimately, the resulting sets will be shared across each discipline community to foster a shared set of standards. This crosswalk will result in a discipline-specific metadata generator. It is envisioned that this discipline-specific metadata generator will be an online system that allows researchers and their assistants to develop metadata on the fly. The discipline-specific metadata generator will crosswalk to Dublin Core ultimately ensuring sharing, discoverability and interoperability of data seamlessly while minimizing researcher effort. The presenters will discuss how they envision the system will work, what steps they are taking in determining key discipline-specific elements - including how those elements crosswalk to Dublin Core - , the progress to date, and the importance of inter-departmental collaboration necessary to make this system a reality.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":64939181,"openaccessinfo":{"externalids":{"MAG":"2601710663","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effects of increased intracranial pressure (ICP) and increased cardiac output (QT) on the pulmonary vascular response to regional alveolar hypoxia were compared in pentobarbital-anesthetized, closed-chested dogs. A bronchial divider was inserted, the right lung (RL) was continuously ventilated with 100% O2, and the left lung (LL) was ventilated with either 100% O2 (hyperoxia) or a hypoxic gas mixture (hypoxia). Sulfur hexafluoride (SF6) was used to measure differential lung blood flow and the multiple inert gas technique assessed gas exchange. The response to LL alveolar hypoxia (hypoxic pulmonary vasoconstriction, HPV) was studied in each animal prior to, during, and after the ICP was increased by infusing mock cerebrospinal fluid (CSF) into a lateral ventricle so that cerebral perfusion pressure was 25 mmHg. During both control periods, QT was randomly altered by opening (high QT) or closing (normal QT) two arteriovenous fistulas. Increasing ICP significantly increased QT (P less than 0.01), pulmonary artery pressure (PAP) (P less than 0.05), and mixed venous oxygen tension (PVO2) (P less than 0.05), compared with normal QT controls. Opening the arteriovenous fistulas achieved similar increases in QT (P less than 0.01), PAP (P less than 0.05), and PVO2 (P less than 0.05). The percentage of blood flow to the LL (QL\/QT%) during hyperoxia was 43.9 +\/- 0.8% (mean +\/- SE) and did not vary with manipulation of QT or ICP. QL\/QT% during LL hypoxia was significantly increased by both increased ICP (24.6 +\/- 3.5%) and high QT (23.1 +\/- 1.0%) compared with normal QT (16.8 +\/- 2.1) controls (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5680118,"openaccessinfo":{"externalids":{"MAG":"2048379815","ACL":null,"DOI":"10.1097\/00000542-199003000-00017","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/72\/3\/490\/635962\/0000542-199003000-00017.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The curing of bone cements is accompanied by release of polymerization heat and, hence, by a temperature rise of the curing cement mass. This temperature rise causes expansion of enclosed air bubbles and evaporation of the volatile monomer. An overall expansion of 3 to 5 vol % has been mentioned in the literature. It has often been stated that this expansion favours the fixation of metal endoprostheses in the marrow cavity of bone. To check for the influence of this expansion on linear dimensions of the cured cement mass we filled stainless steel cylinders with a precision bore of 22,000 +\/- 0,005 mm and a length of 120 mm with bone cement. After curing of the cement in a environment of 37 degrees C the resulting cement rod was released from the cylinder and the diameter of the rod was measured at 37 degrees C. The influence of the \"foaming effect\" on the transverse dimensions of the rods was studied by curing the cement at 37 degrees C and 2 atm air pressure in a high-pressure-vessel. This method of curing eliminates porosity in the cement almost completely, so that curing shrinkage is to be expected rather than expansion of the cement mass. The results indicate that a volumetric expansion of the cement during curing of cylindrical rods in laboratory experiments, can be accompanied by a linear diametrical shrinkage of the cement mass. The explanation of this phenomenon is to be sought in the fact that the volumetric expansion takes place at a time when the cement is still plastic; by the formation of gas bubbles, the cement is forced in longitudinal direction into the cylinder and when the temperature of the mass has passed through a maximum, the cooling of the cement mass results in a thermal shrinkage of approximately 0.4% linearly. Extrapolating this laboratory result to clinical situation one might doubt whether the overall expansion of bone cements during curing will result in a permanent positive pressure on the walls of marrow cavity and whether it will contribute to a better fixation of endoprostheses than in the case of a, still hypothetical, nonporous cement.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36559047,"openaccessinfo":{"externalids":{"MAG":"2024190956","ACL":null,"DOI":"10.1002\/JBM.820090414","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. Trianto A, Radjasa OK, Sabdono A, Muchlissin SI, Afriyanto R, Sulistiowati, Radjasa SK, Crews P, Mccauley E. 2019. Exploration culturable bacterial symbionts of sponges from Ternate Islands, Indonesia. Biodiversitas 20: 776-782. Multidrug resistance, (MDR) bacteria seriously threaten human health which causes a more difficult and extends the treatment period, and increases the risk of death. Sponges-associated bacteria, a well known for their rich in chemical classes and bioactivities, are the prolific producers of bioactive compounds. In order to search new sources of antibacterial compounds, we collected a total of 55 sponges from Ternate Island that provided 324 bacterial isolates. The data showed that sponges-isolates ratio in the anthropogenic area was relatively higher than the other collection sites. The isolates were screened for the antibacterial activity against Klebsiella pneumoniae-RSDK, K. pneumoniae-UI, Pseudomonas aeruginosa A-UI, P. aeruginosa B-UI, Staphylococcus aureus-UI, MRSA-UI, MRPA-UI, Bacillus subtilis-RSDK, B. subtilis-UI, Salmonella typhi-UI, and MDR E. coli. The isolates were able to inhibit 0-7 the pathogenic bacteria on 24 h and 48 h. The most active bacteria were identified as B. clausii, V. chiguensis, B. tropicus, P. marcusii, B. tropicus, V. parahaemolyticus, B. paramycoides, and V. dokdonensis. In conclusion, the sponges in the anthropogenic affected area have higher bacterial symbionts than that of in the pristine area. In this study, the results of isolation of the symbiont bacteria from sponge samples were obtained and morphologically observed for these bacterial isolates. The number of bacteria that were isolated were 133 bacterial isolates and ten isolates including producing active secondary metabolites","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109615186,"openaccessinfo":{"externalids":{"MAG":"2925303706","ACL":null,"DOI":"10.13057\/BIODIV\/D200323","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Large-angle light deflection is accomplished by diffraction from an optically induced index modulation created by the interference of two controlling light beams. The control beam wavelength is used to change the frequency of the transient grating and hence the resulting deflection angle. The Bragg condition is maintained over a wide range of deflection angles by the use of a novel optical system containing diffractive elements operating in real-time to tilt the diffracting structure. The results of a computer simulation and optimization program are presented together with experimental verification demonstrating 11.8\u00b0 deflection from a 0.027 \u03bcm wavelength change.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":109785403,"openaccessinfo":{"externalids":{"MAG":"1991369722","ACL":null,"DOI":"10.1117\/12.935248","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Currently, Corona-virus disease (COVID-19), one of the most infectious diseases in the 21st century, is a highly contagious viral infection with a severe impact on global health. It also affected the global economy very badly. This virus threatens human's life, and it is necessary to design a monitoring device to monitor the patient's health remotely to avoid the spread of infection to doctors or nurses. In this paper, a wearable device which contains two sensors are used to measure blood oxygenation, body temperature, and heart rate. Then send these readings to the server to analyze them and send warning notifications to the patient's assistant phone to inform him of whether the oxygen level is low, the heart rate is irregular or the patient's temperature is high to perform a certain procedure to","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237005780,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino group play a role in the binding of all the aflatoxins to DNA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1643875,"openaccessinfo":{"externalids":{"MAG":"2223160714","ACL":null,"DOI":"10.1042\/BJ1030467","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A number of studies have shown that approximately one-quarter of children in potentially bilingual environments do not become bilingual. This article explores several key factors that influence the likelihood that a child who has access to interactions in two languages will learn them both. The five factors discussed are input, language status, access to literacy, family language use, and community support, including schooling. It is argued that the quantity of input has the greatest effect on whether a minority language will be learned, but language status and attitudes about language also play a role. When families are proactive and provide daily activities for children in the minority language, the children respond by learning it. In addition, dual-immersion, \"two-way\" schooling is shown to benefit children's level of language proficiency in the minority language without diminishing their progress in the community language.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":145275632,"openaccessinfo":{"externalids":{"MAG":"2147521188","ACL":null,"DOI":"10.1017\/S014271640707021X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Young people in rural areas are under-researched, and there is a particular paucity of studies on rural youth in the labour market. This paper addresses that dearth. I pose the research question: how does rural location affect the earnings of young people in full-time employment in Britain? I consider the background of rural disadvantage, and its specific effects on young people and outline the relevance of social capital to this topic, identifying norms and networks as the two constituent elements of the concept. Using data from the British Household Panel Survey Wave 17 (2007\/8), I find that rural youth are paid less than urban counterparts. When coupled with higher living costs, this amounts to a double disadvantage for rural youth. Concerning social capital, I find that norms \u2013 in terms of trust in individuals, community and institutions \u2013 exert a significant effect on net pay. Conversely, despite prior research positing the importance of informal contacts for rural jobseekers, networks do not exhibit any significant effect on wages. This corroborates accounts of social capital as a protean concept, illustrating how one facet alters the likelihood of finding work, while the other facet determines outcomes once in employment.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":143444678,"openaccessinfo":{"externalids":{"MAG":"2008338704","ACL":null,"DOI":"10.1080\/13676261.2013.793788","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13676261.2013.793788?needAccess=true&role=button","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The prevalance of a number of malocclusion traits was investigated for 1,000 modern British caucasoid, 70 medieval British, 60 Anglo-Saxon, 100 negroid and 100 mongoloid dentitions. Marked contrasts were evident in the sagittal, vertical and transverse occlusal and spacing anomalies between the various samples, with dental crowding being particularly prevalent in the modern British caucasoid sample and spacing between the teeth in the Anglo-Saxon sample. The method of quantification of malocclusions was shown to be applicable for other epidemiologic studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6429505,"openaccessinfo":{"externalids":{"MAG":"2059638845","ACL":null,"DOI":"10.1111\/J.1600-0528.1976.TB00967.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We introduce the category NCSet consisting of neutrosophic crisp sets and morphisms between them. And we study NCSet in the sense of a topological universe and prove that it is Cartesian closed over Set, where Set denotes the category consisting of ordinary sets and ordinary mappings between them. 2010 AMS Classification: 03E72, 18B05","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3659506,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background. Family caregivers may be at a higher risk for several chronic diseases including cancer. Cervical cancer is one of the most prevalent cancers among U.S. women. Despite family caregivers' vulnerability, the status of their HPV awareness, knowledge, and preventive health behaviors, including cervical cancer screening, have been understudied. Thus, this study aimed to examine the sociodemographic factors associated with HPV awareness and knowledge, and adherence to the cervical cancer screening guidelines among caregivers in the U.S. Methods. Nationally representative cross-sectional survey data were obtained from the Health Information National Trends Survey (HINTS 5, 2017-2020). Only female caregivers, aged 21-65, were included (N= 834). Weighted multivariate logistic regression was performed to identify factors associated with HPV awareness, knowledge, and adherence to the United States Preventive Service Task Force cervical cancer screening guidelines (by age, race\/ethnicity, education, household income, marital status, employment status, and health insurance type). Results. Caregivers who were older (aged 51-65 vs. 21-50), were less educated (high school graduate or less vs. some college or more) showed lower adherence to the cervical cancer screening guidelines (every 3 years) than their counterparts. Caregivers who were older and less educated showed lower HPV awareness (Heard of HPV).Conclusions. There are caregiving populations whose HPV awareness, knowledge and cervical cancer screening adherence are low. To improve their awareness and knowledge of HPV and support their cervical cancer screening behaviors, we need to consider interventions that target those specific populations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245379419,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-1120326\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/escholarship.org\/content\/qt1v31k721\/qt1v31k721.pdf?t=rxccsu","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Children and adolescents with type 1 diabetes mellitus (T1DM) are at risk for a variety of problems at school. Well\u2010controlled studies using data collected in schools, however, are limited. The purposes of this study are to determine whether selected school problems are associated with T1DM and to investigate an association between these problems and medical variables. Teachers rated 95 diabetic students (M = 11.8; SD = 3.0 yr old) and 95 of their siblings (M = 12.1; SD = 3.0 yr old) regarding academic skills, work completion, day\u2010to\u2010day variability, and classroom attention. Medical and school records also were accessed. The T1DM group had lower academic skills ratings overall (p < 0.02), especially in writing (p < 0.01), a trend toward poorer classroom attention (p < 0.08), and many more missed school days (p < 0.001). Diabetics on intensive therapy protocols had better academic ratings overall (p < 0.02), including in math (p < 0.03) and fewer missed school days (p < 0.03), but they unexpectedly were rated as having more classroom behaviors that jeopardize work completion (p < 0.05) than counterparts on conventional therapy. Among all diabetics, glycated hemoglobin (HbAlc) levels were moderately related to each academic skill rating (r = \u22120.34 to \u22120.37; p < 0.01) and strongly related to classroom attention (r = 0.53; p = 0.000). T1DM itself appears to be a relatively minor influence to several important aspects of school. Furthermore, although intensive therapy alone may well promote school success, meticulous glycemic control, however achieved, appears more important in mitigating prospective classroom attention and academic problems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":396387,"openaccessinfo":{"externalids":{"MAG":"2130598075","ACL":null,"DOI":"10.1111\/j.1399-5448.2009.00532.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1111\/j.1399-5448.2009.00532.x","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Parents of children with special healthcare needs (CSHCN) face tremendous stress in caring for their children. Families of CSHCN face increased barriers to health services as evidence also reflects the influence of socioeconomic factors on access. This study investigates the impact of socioeconomic factors and family functioning on delayed care. Descriptive, bivariate, and adjusted multivariate logistic regression were performed using sampling weights. findings suggest that family dynamics are more impactful on delayed care than socioeconomic predictors. Promoting family-centered care that incorporates social support for families to reduce barriers is essential for improved quality of life and health outcomes.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":52041206,"openaccessinfo":{"externalids":{"MAG":"2888344680","ACL":null,"DOI":"10.1080\/19371918.2018.1504703","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arro.anglia.ac.uk\/id\/eprint\/703570\/1\/Nyathi_2018.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The kinetics of oxidation of several para - substituted benzaldehydes by imidazolium fluorochromate (IFC) has been studied in the presence of p -toluenesulphonic acid (TsOH) in different (hydrogen bond donor and hydrogen bond acceptor) organic solvents. The reaction was run under pseudo-first-order conditions. Various thermodynamic parameters for the oxidation have been reported and discussed along with the validity of isokinetic relationship. The rate data showing satisfactory correlation with Kamlet-Taft solvatochromic parameters ( \u03b1, \u03b2 and \u03c0* ) which suggests that the specific solute-solvent interactions play a major role in governing the reactivity, and the observed solvent effects have been explained on the basis of solute-solvent complexation.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":55984054,"openaccessinfo":{"externalids":{"MAG":"1506520648","ACL":null,"DOI":"10.17628\/ECB.2013.2.538-544","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is well known that highly sensitized patients and\/or high responders, even under CsA therapy, constitute a risk category for transplantation. Based on this evidence, in 1982, our group initiates a pilot study using total lymphoid irradiation (TLI) as a pre-transplant modulator of patient's immuno-response. TLI has been employed in 30 uremic, non diabetic, patients. During this experience the first protocol, characterized by pre-transplant TLI greater than 2,000 rads (13 pts.) and post-transplant conventional therapy, was abandoned because of the severe TLI side effects. In the second protocol TLI dose never exceeded 2,000 rads and CsA was given, at initial dose of 7-12 mg\/Kg\/day according to CsA blood through levels. The immunological monitoring was performed during TLI treatment and in the postoperative clinical course by cell markers profile determination and functional assays. The data obtained have demonstrated that TLI treatment causes a prolonged depression in CD4 positive cells, a predominant recovery of T suppressor population, a pronounced impairment of T functions and a development of specific unresponsiveness to donor antigens. Furthermore the TLI plus CsA protocol, showing an additive effect which steadily decreases patient immunoreactivity, a lack of side effects and a stable long term graft function seems to be a more useful method for transplantation in high-risk or in strongly immunoreactive patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25442740,"openaccessinfo":{"externalids":{"MAG":"2412186867","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The stereochemical influence of antioxidant and flavanol compounds on oxidation processes in a model wine system was studied. The diastereoisomers, ascorbic acid and erythorbic acid, were used as antioxidants in a model wine system containing either (+)-catechin or (-)-epicatechin as the oxidizable flavanol compound. Samples were stored at 45 degrees C for a period of 14 days and analyzed by UV\/visible spectrometry, CIELab, UPLC-PDA, and LC-MS. The results showed that less brown oxidative coloration occurred for samples with erythorbic acid for a given flavanol compound, while (+)-catechin provided less yellow coloration for a given antioxidant. Although erythorbic acid was degraded faster than ascorbic acid, it was associated with less decay in the accompanying flavanol compound. Xanthylium cation pigments were identified as the major contributor to color development. Furthermore, the production of pigment precursors, previously identified as furanone-substituted flavanols, was confirmed in all cases and their corresponding xanthylium cation pigments were lower in the presence of erythorbic acid than ascorbic acid. The results demonstrate that erythorbic acid is more efficient at minimizing oxidative color development than ascorbic acid in the model wine system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22194498,"openaccessinfo":{"externalids":{"MAG":"2015824953","ACL":null,"DOI":"10.1021\/jf903233x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Data mining research has yielded many significant and useful results such as discovering consumer-spending habits, detecting credit card fraud, and identifying anomalous social behavior. Information discovery and analysis systems (IDAS) extract information from multiple sources of data and use data mining methodologies to identify potential significant events and relationships. This research designed and developed a tool called IDAS data and scenario generator (IDSG) to facilitate the creation, testing and training of IDAS. IDSG focuses on building a synthetic data generation engine powerful and flexible enough to generate synthetic data based on complex semantic graphs","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15808040,"openaccessinfo":{"externalids":{"MAG":"2143608744","ACL":null,"DOI":"10.1109\/ITNG.2006.51","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this Letter, a highly reconfigurable crossbar transmission line switch matrix for magnetic resonance imaging (MRI) system is proposed. Unlike the conventional M \u00d7 N crossbar switch configuration, the proposed structure can manipulate 2M \u00d7 N matrix without doubling the area occupancy. Also, the proposed structure includes the signal loss-compensation circuitry based on inductor banks to enhance signal-to-noise ratio (SNR). Thus, for any required numbers of input and output channels, the proposed structure can reduce the overall size, the number of required component, and even increase the quality of MR images by SNR enhancement. The proposed structure was implemented and verified at 4-Tesla (170 MHz) MR system through the comparison of RF path loss, SNR and phantom test image qualities.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":114438442,"openaccessinfo":{"externalids":{"MAG":"2582752074","ACL":null,"DOI":"10.1049\/EL.2016.4489","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A medium-sized Schwarzchild-Couder Telescope (SCT) is being developed as a possible extension for the Cherenkov Telescope Array (CTA). The Cherenkov camera of the telescope is designed to have 11328 silicon photomultiplier pixels capable of capturing high-resolution images of air showers in the atmosphere. The combination of the large number of pixels and the high trigger rate (> 5 kHz) expected for this telescope results in a multi-Gbps data throughput. This sets challenging requirements on the design and performance of a data acquisition system for processing and storing this data. A prototype SCT (pSCT) with a partial camera containing 1600 pixels, covering a field of view of 2.5 x 2.5 square degrees, is being assembled at the F.L. Whipple Observatory. We present the design and current status of the SCT data acquisition system.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":118477618,"openaccessinfo":{"externalids":{"MAG":"2949366403","ACL":null,"DOI":"10.22323\/1.236.0987","PubMedCentral":null,"ArXiv":"1509.00710"},"license":"CCBYNCSA","url":"https:\/\/pos.sissa.it\/236\/987\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nASPP2 is an independent haploinsufficient tumor suppressor (Kampa et al., PNAS2009) and studies in tumors including breast cancer and aggressive lymphoma have shown that attenuation\/loss of ASPP2 is a common occurrence. In acute leukemia, we have evidence that attenuation of ASPP2 significantly associates with higher-risk disease and poor clinical outcome (Schittenhelm et al.,ASH2012).\n\nIn an attempt to screen for ASPP2 gene\/transcript aberrations we identified two novel splicing variants of ASPP2 in acute myeloid and lymphoid leukemia blasts from 80 consented patients: The more prevalent isoform lacking exon 17, named ASPP2\u03ba, was detected in >30% of patients. ASPP2\u03bc, lacking ex16\/17, was identified in one patient. A quantitative (q)PCR assay on genomic DNA to compare exon 15 versus exon 17 expression levels did not reveal any significant differences arguing for a splicing event rather than mutation. Isolating CD34(+) leukemia blasts using cell sorting technology demonstrated ASPP2\u03ba-expression in leukemia stem\/progenitor cells.\n\nLack of exon 16 (resp. exon 16\/17) results in a reading frame-shift with a premature translation stop, omitting most of the C-terminus - which harbors the p53-binding sites. We generated isoform-specific antibodies directed against the hypothetical fusion site. Sequence-specificity was confirmed by BlastN search. Co-immunoprecipitation using antibodies targeting the ASPP2 N-terminal and probing for ASPP2\u03ba-specific antibodies revealed genuine translation into two protein isoforms (ASPP2\u03ba-1\/2, corresponding to ASPP2-1\/2) with the predicted sizes of 97 and 111 kDa. Western immunoblotting and intracellular semi-quantitative immunophenotyping of freshly isolated native leukemia as well as bone marrow donor samples demonstrated ASPP2\u03ba-1\/2 to be specifically expressed in leukemia.\n\nAdditionally we developed a highly isoform\u2014specific qRT-PCR assay running on a light-cycler platform: A restriction motif-specific ASPP2 exon 17 digest was performed to deplete \"wildtype\" ASPP2 and ASPP2\u03ba-specific primer were generated. Although ASPP2\u03ba amplicons were detectable in physiologic cells, high expression levels were exclusively found in leukemic blasts. Tantalizingly ASPP2\u03ba as well as ASPP2\u03bc dramatically decreased in patients achieving complete remission (CR) - whereas patients failing remission retained high transcript levels.\n\nPreliminary data suggest, that transfection of ASPP2\u03ba in murine pro-B Ba\/F3 cells renders cells to more aggressive biology with mitotic failure and perturbed cellular proliferation. Systematic analysis of other tumor entities and functional analysis including other models are ongoing.\n\nIn summary, we identified two novel ASPP2 splice variants lacking the p53-binding site - which are predominantly detected in acute leukemia and may link to early tumorigenesis.\n\nCitation Format: Kerstin M. Kampa-Schittenhelm, Charles D. Lopez, Barbara Illing, Michael Walter, Marcus M. Schittenhelm. Identification of C-terminal truncated splice variants of the apoptosis-stimulating protein of p53-2 (ASPP2) in acute leukemia. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-49. doi:10.1158\/1538-7445.AM2013-LB-49","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":85128170,"openaccessinfo":{"externalids":{"MAG":"2061899354","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-LB-49","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multimodal emotion recognition leverages complementary information across modalities to gain performance. However, we cannot guarantee that the data of all modalities are always present in practice. In the studies to predict the missing data across modalities, the inherent difference between heterogeneous modalities, namely the modality gap, presents a challenge. To address this, we propose to use invariant features for a missing modality imagination network (IF-MMIN) which includes two novel mechanisms: 1) an invariant feature learning strategy that is based on the central moment discrepancy (CMD) distance under the full-modality scenario; 2) an invariant feature based imagination module (IF-IM) to alleviate the modality gap during the missing modalities prediction, thus improving the robustness of multimodal joint representation. Comprehensive experiments on the benchmark dataset IEMOCAP demonstrate that the proposed model outperforms all baselines and invariantly improves the overall emotion recognition performance under uncertain missing-modality conditions. We release the code at: https:\/\/github.com\/ZhuoYulang\/IF-MMIN.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":253157905,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ICASSP49357.2023.10095836","PubMedCentral":null,"ArXiv":"2210.15359"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Logistics distribution has become the key research to improve efficiency and reduce the cost of logistics.Based on the survey of current situation and optimization algorithms, a novel optimization scheme is presented in this paper.For a lot of distribution sites in a city, firstly K-means clustering algorithm is adopted to get local distribution centers and their scope, and then ant colony algorithm is used to design the local optimal route inside each scope. The simulation results show that the presented scheme can improve the optimal distribution route compared to pure ant colony algorithm.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62974184,"openaccessinfo":{"externalids":{"MAG":"2381590038","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Apoptosis can occur in several pathological heart conditions. Physical exercise, particularly aerobic exercise may reduce apoptosis on cardiomyocytes. Detraining can restore adaptation after exercise. This study aimed to see the effect of aerobic exercise and detraining on left ventricular cardiomyocyte apoptosis using caspase-3 as the parameter.This was an in vivo experimental study on Wistar rats Rattus Novergicus. Rats divided to 8 groups: 4 sedentary control groups: 4-week (C4), 8-week (C4D), 12-week (C12), 16-week control (C12D), and 4 aerobic exercise treatment groups: 4-week (A4) and 12-week (A12), and 4 a 12-week post aerobic exercise treatment followed by 4 weeks detraining (A4D, A12D). Caspase-3 protein in rat left ventricular tissue was identified by immunohistochemistry staining. Data were analized with ANOVA test using SPSS proggramme version 20.Data analysis showed an increase percentage of caspase-3 expression on post-aerobic exercise (A), be compared with conntrol group (C) (A4 65,3%2,54 vs K4 6,4%1,78, pl0,001; A12 41,8%3,21 vs K12 5,7%0,88, pl0,001; A4D 66,6%1,89 vs K4D 8,6%3,60, pl0,001; A12D 45,1%1,50 vs K12D 7,4%2,06, pl0,001). Percentage of caspase-3 expression was not different on post-aerobc exercise (A), be compare with detraining group (A4D 66,6%1,89% vs A4 65,4%2,54, p=0,484; A12D 45,1%1,50 vs A12 41,8%3,21, p=0,063). Percentage of caspase-3 expression on post 4-week aerobic exercise group was higher than post12-week aerobic exercise (A4 65,4%2,54 vs A12 41,8%3,21, pl0,001).In conclusion, the aerobic exercise protocol used in this study, was not found to decrease left ventricular cardiomyocyte apoptosis. Detraining did not increase left ventricular cardiomyocyte apoptosis.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55361458,"openaccessinfo":{"externalids":{"MAG":"2616592028","ACL":null,"DOI":"10.33476\/jky.v24i3.276","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A Wireless Sensor Network can be defined as a group of sensors which are distributed spatially to monitor physical or spatial conditions such as temperature, volcano, fire monitoring, sound, urban sensing, pressure etc. In a large WSN, the data aggregation significantly reduces communication overhead and energy consumption. In order to pass data, although data in-network aggregation was used and it reduced the problem of communication overhead and transmission loss but failed in computing doublecounting sensitive aggregates at the Base Station. The research community proposed synopsis diffusion to eliminate this problem but it did not helped in securing the network against the problem of attacks caused by the compromised nodes, resulting in the false computation of aggregate. In this paper, synopsis diffusion is being made secure against the attacks by compromised nodes. To do so, an algorithm is being presented which can securely compute aggregates in the presence of such attacks. This algorithm is named as Attack-Resilient algorithm. The attack-resilient algorithm computes the true aggregate by filtering out the contributions of compromised nodes in the aggregation hierarchy. Extensive studies and performance analysis have shown that the proposed algorithm i.e. AttackResilient algorithm is more effective and outperforms other existing approaches.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21734707,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the recent years, the Web has undergone a tremendous growth regarding both content and users. This has lead to an information overload problem in which people are finding it increasingly difficult to locate the right information at the right time. Recommender systems have been developed to address this problem, by guiding users through the big ocean of information. Until now, recommender systems have been extensively used within e-commerce and communities where items like movies, music and articles are recommended. More recently, recommender systems have been deployed in online music players, recommending music that the users probably will like. This thesis will present the design, implementation, testing and evaluation of a recommender system within the music domain, where three different approaches for producing recommendations are utilized. Testing each approach is done by first conducting live user experiments and then measure recommender precision using offline analysis. Our results show that the functionality of the recommender system is satisfactory, and that recommender precision differs for the three filtering approaches.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":15186688,"openaccessinfo":{"externalids":{"MAG":"2150182025","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Despite the availability of various treatment options, the inherent complexity of tumors significantly impairs therapeutic efficacy. Recently, combination treatments exhibited great anticancer potential due to low cross-resistance and good therapeutic additivity. Herein, a photoactive metal oxide-black phosphorus biomimetic nanocomplex (photophage) is developed for improving the antitumor combination of ferroptosis and photodynamic therapy (PDT). The photophage is composed of M1 macrophage membrane camouflaged MnO2 and Fe3O4 nanoparticles anchored black phosphorus nanosheets (BPNs), which together trigger a synergistic antitumor action. Fe3O4 acts as an iron source to activate Fenton-reaction-dependent ferroptosis, which can be further strengthened by BPN-mediated PDT. Besides the original antitumor effects, PDT also generates reactive oxygen species to enhance lipid peroxidation and glutathione depletion, which in turn reinforce ferroptosis and PDT efficacy. Importantly, MnO2 can in situ generate oxygen to relieve tumor hypoxia and consequently leverage cell behaviors to improve therapeutic responses. Particularly, M1 macrophage membrane modification endows the photophage with good tumor targeting capability and tumor penetration, which promote synergistic ferroptosis and PDT to destroy tumors while reducing systemic side effects, resulting in the prolonged survival of tumor-bearing mice. Therefore, we present a biomimetic nanoplatform for overcoming tumor barriers and advancing tumor-targeted treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249395781,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acsami.2c08413","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For a thin-film transistor (TFT) built on excimer-laser crystallized polycrystalline silicon, the dependence of the effective ldquograin-boundary mobilityrdquo on the gate-to-source voltage can be divided into two subregimes exhibiting different power-law characteristics. An expression for the effective mobility is developed using a procedure previously proposed for a TFT built on polycrystalline silicon exhibiting only single power-law dependence. The additional power-law component is reflected in the model by a pair of measurable and physically meaningful parameters. The procedure for determining these parameters is described and demonstrated. Both the measured and calculated transfer characteristics are reported and compared. The double power-law dependence implies a grain-boundary trap-state energy dispersion characterized by two exponential functions. This is presently verified.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":44825045,"openaccessinfo":{"externalids":{"MAG":"2111314563","ACL":null,"DOI":"10.1109\/LED.2009.2029352","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There is an urgent need to test recently constructed conceptual models of landscape evolution and geomorphology against field data. Many statistics that have commonly been used, such as Strahler statistics, are poorly suited to this testing being unable to potentially falsify the models when applied in controlled conditions. The relations between these statistics and catchment mass movement processes are, in many cases, indirect. Moreover, they are sensitive to unknowable inputs (e.g., initial conditions). One of the main differences among the competing landscape evolution models is their representation of mass movement and erosion processes, so that statistics that are directly linked to these processes, or their geomorphic signature, are needed. This paper examines the use of a log-log linear relation between catchment area, slope, and elevation. This relation has been previously derived quantitatively from the catchment erosion and hydrologic processes for dynamic and declining geomorphic equilibria. Using a catchment evolution model, this paper shows that the relation is robust against deviations from the assumptions of spatial and temporal homogeneity of erosion, climate, and tectonic uplift made in its derivation. The sensitivity of the geomorphology to time-varying tectonic uplift and climate and spatially variable soil erodability is examined. It is thus asserted that the relation between area, slope, and elevation is suitable for testing of models against field data, where spatial and temporal homogeneity of erosion, climate, and tectonic uplift are only approximately true. In the case of variable soil erodability, planar drainage patterns exhibit self-organization with the high elevation regions of the catchment having low soil erodability. Consequently, a downstream increasing erodability of the soil material, consistent with a downstream fining type of behavior, is observed. It is further argued that the equilibria relation is fundamental and uniquely defines the elevation form of catchments so that all other elevation statistics are derived from it.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":131499509,"openaccessinfo":{"externalids":{"MAG":"2146175595","ACL":null,"DOI":"10.1029\/94JB00123","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Homa Katouzian offers a groundbreaking theoretical framework for the study of Modern Iranian history. In the model, he proposes, Katouzian identifies a cycle of arbitrary rule leading to chaos, resulting in a further period of arbitrary rule, degenerating once more into chaos, and so on. The ebb and flow between the despotism of Naser al-din Shah, the confusion and turmoil of the Constitutional Revolution and the late Qajar period, the tough one-man-rule of Reza Shah, the ramshackle democracy and vacuum following World War II, the centralism of Mohammed Reza Shah underpinned by SAVAK, the brief flowering of democracy around the Islamic Revolution, only to culminate in the stern arbitrariness of rule guided by the hubris of an Islamic leader (first Khomeini then Khamene'i) - all bear out the author's thesis with uncanny accuracy. \"State and Society in Iran\" is crucial reading not only for those interested in the history of modern Iran but also for all students of political science concerned with the developing world.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":187753249,"openaccessinfo":{"externalids":{"MAG":"1566226720","ACL":null,"DOI":"10.5040\/9780755609727","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The H5N1 subtype of highly pathogenic avian influenza virus has been circulating in poultry in Indonesia since 2003 and vaccination has been used as a strategy to eradicate the disease. However, monitoring of vaccinated poultry flocks for H5N1 infection by serological means has been difficult, as vaccine antibodies are not readily distinguishable from those induced by field viruses. Therefore, a test that differentiates infected and vaccinated animals (DIVA) would be essential. Currently, no simple and specific DIVA test is available for screening of a large number of vaccinated chickens. Several epitopes on E29 domain of the haemagglutinin H5N1 subunit 2 (HA2) have recently been examined for their antigenicity and potential as possible markers for DIVA in chicken. In this study, the potential of E29 as an antigen for DIVA was evaluated in detail. Three different forms of full-length E29 peptide, a truncated E29 peptide (E15), and a recombinant E29 were compared for their ability to detect anti-E29 antibodies. Preliminary ELISA experiments using mono-specific chicken and rabbit E29 sera, and a mouse monoclonal antibody revealed that the linear E29 peptide was the most antigenic. Further examination of the E29 antigenicity in ELISA, using several sera from experimentally infected or vaccinated chickens, revealed that the full-length E29 peptide had the greatest discrimination power between infected and vaccinated chicken sera while providing the least non-specific reaction. This study demonstrates the usefulness of the HPAI H5N1 HA2 E29 epitope as a DIVA antigen in HPAI H5N1-vaccinated and -infected chickens. RESEARCH HIGHLIGHTS E29 (HA2 positions 488-516) epitope is antigenic in chickens. Antibodies to E29 are elicited following live H5N1 virus infection in chickens. E29 epitope is a potential DIVA antigen for use in ELISA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208165166,"openaccessinfo":{"externalids":{"MAG":"2983722260","ACL":null,"DOI":"10.1080\/03079457.2019.1694635","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/03079457.2019.1694635?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In this paper we study the factors that influence both dropout and degree completion (4 or 5 years to earn a degree) at university using survival analysis. In particular, we apply the set of discrete-time methods for competing risks event history analysis described in Scott and Kennedy (2005). Using the competing risks model, we show that foreign students are more likely to experience consecutive enrollments without actually getting a degree. Also, having a mother with a higher education degree reduces significantly the risk of dropping out and at the same time increases the chance of graduation. Finally, the impact of a variable can evolve throughout the academic path. For example, \"having chosen a strong mathematical profile during high school \" reduces significantly the risk of dropping out only in the early years of study.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":73542011,"openaccessinfo":{"externalids":{"MAG":"1567565907","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report the case of a 31-year-old Chinese woman with a chief complaint of weakness in the lower limbs, which was diagnosed as limb-girdle muscular dystrophy 2B (LGMD2B) with compound heterozygous mutations of the DYSF gene. Meanwhile, this woman is an asymptomatic carrier with the mutation of the X-linked DMD gene. The electromyography, muscle MRI, and muscle biopsy indicated a chronic myogenic injury with dysferlin deletion. As a result of genetic testing, compound heterozygous G-to-T base substitution at position 5,497 in exon 49 of the DYSF gene, leading to a codon change from glutamic acid to termination codon at position 1,833, and a heterozygous C-to-G base change at position 4,638 + 8 in intron 42 of the DYSF gene with a consequence of splice, which has never been reported, were identified as candidate causative mutations. Unfortunately, DMD gene mutation c.3921+12A>G of the DMD gene on the X chromosome was also found in this patient. Finally, the patient was diagnosed as LGMD2B clinically and genetically. In the previous 2 years, the patient's lower limb weakness became slightly worse, resulting in even the total distance walked than before. Fortunately, during the follow-up, her son had not shown slowness or limitation of movement. Genetic testing by next-generation sequencing confirmed the final diagnosis of LGMD2B, and we identified the novel compound heterozygous variants in the DYSF gene, which is of great significance to the accurate diagnosis of genetically coded diseases. Much attention needs to be paid in clinics toward hereditary neuromuscular diseases with multiple pathogenic gene mutations. Genetic counseling and clinical follow-up should be the priorities in future, and promising treatments are also worth exploring.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263245790,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fneur.2023.1213090","PubMedCentral":"10564995","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2023.1213090\/pdf?isPublishedV2=False","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Behavioral characteristics such as aggressiveness and predation preference of the phytoseiid predatory species, Amblyseius swirskii, Neoseiulus californicus and Phytoseiulus persimilis (Acari: Phytoseiidae) were investigated when applied together. We quantified the chance and time of a successful attack to a heterospecific larva as aggressiveness of adult females. In order to the determine the predation preference of adult females equal combination of con\/heterospecific larvae were presented to as prey in absence of their main prey (Tetranychus urticae Koch) for 24 h. Experiments were carried out in growth chamber at 25\u00b11 oC, 65\u00b15% RH and 16:8 (L: D) hour photoperiod regimens. The results showed that adult females of N. californicus needed 39.65\u00b17.46 min. to attack and kill the larva of P. persimilis which was remarkably less than that recorded (227.80\u00b128.38 min.) for adult females of P. persimilis to attack and kill N. californicus larva. N. californicus was estimated more aggressive than P. persimilis. The mean estimated attack time of A. swirskii and P. persimilis was estimated 18.55\u00b12.89 and 201.70\u00b125.42 min., respectively. A. swirskii was considered more aggressive than P. persimilis against heterospecific larvae. The predation preference index (Manly \u0301s \u03b2) were indicated that N. californicus was able to recognize con\/heterospecific larva, resulted more preference for heterospecific larvae (P. persimilis) in absence of T. urticae, while adult P. persimilis showed no preference (between con and heterospecific larva). Manly \u0301s \u03b2, for A. swirskii was 0.706 and 0.294, for P. persimilis 0.369 and 0.630 on hetero and conspecific larvae, respectively. Results of this study showed that, A. swirskii and N. californicus are general predators were able to roecgnize con\/heterospecific larva and preferred to feed on heterospecific larvae and get benefit from intraguild predation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207871000,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This psychosocial study attempts to shed light on the essential distinction between memory and recollection, and suggests a view of forgetfulness in terms of its intrinsic links with transmission. We study the effects and manifestations of collective forgetfulness, which still remain under-explored in psychology. The relatively recent case of a rumour that offered an explanation for and asserted the unprecedented character of a natural disaster\u2014a symptom of forgetfulness\u2014will serve as the basis for our investigation. The qualitative methodological design (documentary research, focus groups) used in this research reveals that the group has not transmitted its own painful past and that the rumour that continues to be promulgated offers an explanation which suits the residents, demonstrating much about their identity and history in the process. This paper will attempt therefore to investigate the ways in which this forgetfulness is transmitted, as well as the evident paradox of its coexistence with the recollection of history within the collective memory of the very same group.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":146425120,"openaccessinfo":{"externalids":{"MAG":"2156664393","ACL":null,"DOI":"10.1177\/1354067X12464986","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Through the analysis of infrared transmittance of a natural cloud, its drop-size distribution can be inferred. This technique has been used to measure and analyze ten cloud situations on Mount Washington. These clouds show drop-size distributions that are bimodal in character. In all the distributions, a large number of small droplets is inferred. To test the synthesized distributions in another region of the spectrum, the visual range was computed. This determination of the visual range is in agreement with the observed visibilities.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":120005845,"openaccessinfo":{"externalids":{"MAG":"1994476768","ACL":null,"DOI":"10.1175\/0095-9634-14.1.55","PubMedCentral":null,"ArXiv":null},"license":"unspecified-oa","url":"http:\/\/journals.ametsoc.org\/doi\/pdf\/10.1175\/0095-9634-14.1.55","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract We evaluated reattached tooth fragments in terms of fracture resistance in endodontically treated maxillary premolars with one remaining wall. In total, 60 double-rooted, mature, human maxillary premolars with double canals were used. Ten intact teeth were served as a control group without any application. After endodontic treatment, the palatal wall of the teeth was cut parallel to the horizontal axis on the cementoenamel junction using a diamond disc. The teeth were randomly divided into five groups (n = 10) and were restored as follows. Group 1: restored with composite resin; Group 2: palatal wall bonded to the teeth using adhesive resin, then restored with composite resin; Group 3: teeth restored as in Group 2, plus a post space prepared below 2 mm from the palatinal cusp horizontally, then fibre post bonded using adhesive resin cement; Group 4: cavity enlarged to a depth of 2 mm in the cusp of the palatal wall, then restoration performed as in Group 2; and Group 5: fibre post placed in the root canal and then restoration performed as in Group 1. Failure load testing was performed with a universal testing machine. Kruskal\u2013Wallis and Conover's multiple comparison tests were used to analyse the data. In the restoration groups the highest median load at failure was observed in Group 4, in which cusp capping was used; the lowest was found in Group 3, in which a horizontal fibre post was applied with the reattached tooth fragments.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":137821145,"openaccessinfo":{"externalids":{"MAG":"2319002872","ACL":null,"DOI":"10.1080\/01694243.2016.1155920","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A series of gem-chlorosulfurization products bearing difluoromethyl substituents were synthesized in high to excellent yields directly from p-toluenesulfonyl difluorodiazoethane (TsCF2CHN2), disulfides and PhICl2 without any catalysts or additives. The mild reaction conditions and high functional group compatibility indicated the utility and sustainability of the method. In addition, the gem-chlorosulfurization products could be efficiently converted to sulfur-containing and aryl substituted difluoromethyl derivatives by a feasible multi-component operation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263567987,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1039\/d1ob01422f","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a novel method to automatically build a named entity corpus based on the DBpedia ontology. Since most of named entity recognition systems require time and effort consuming annotation tasks as training data. Work on NER has thus for been limited on certain languages like English that are resource-abundant in general. As an alternative, we suggest that the NE corpus generated by our proposed method, can be used as training data. Our approach introduces Wikipedia as a raw text and uses the DBpedia data set for named entity disambiguation. Our method is language-independent and easy to be applied to many different languages where Wikipedia and DBpedia are provided. Throughout the paper, we demonstrate that our NE corpus is of comparable quality even to the manually annotated NE corpus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":8642539,"openaccessinfo":{"externalids":{"MAG":"2250837776","ACL":"L14-1540","DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of the present study was to establish whether the early signs of various orofacial dysfunctions, malocclusions, or occlusal interferences can predict the development of temporomandibular dysfunction (TMD) in young adults. Forty-eight subjects referred for speech therapy and 49 controls participated in all four stages of this longitudinal study. The subjects were examined at the ages of 7, 10, 15, and 19 years. The phoniatrician diagnosed errors in place of articulation and problems in the movement and co-ordination of the speech articulators. Occlusion, TMD signs (palpatory tenderness of the masticatory muscles, and of temporomandibular joints (TMJ), jaw deviation on opening, and clicking), mandibular movement capacity and occlusal interferences were registered by the orthodontist. Multiple logistic regression models were applied in order to evaluate whether single signs of TMD at the age of 19 years were related to previous\/present malocclusions or interferences, to misarticulations of speech, problems in oral motor skills, or other signs of TMD. The effect of gender was also considered. The results showed that excessive overjet was the only variable which seemed to consistently increase the risk of TMD. In addition, girls seemed to be more prone to the development of TMD than boys. Although, during growth, there were both local and central factors associated occasionally with TMD development, the predictive value of those variables in the estimation of the individual risk of TMD was rather small.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11840916,"openaccessinfo":{"externalids":{"MAG":"2064219229","ACL":null,"DOI":"10.1093\/EJO\/26.4.367","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have previously described protective effects of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) on pulmonary endothelial cell (EC) barrier function and demonstrated the critical role of cyclopentenone-containing modifications of arachidonoyl moiety in OxPAPC protective effects. In this study we used oxidized phosphocholine (OxPAPC), phosphoserine (OxPAPS), and glycerophosphate (OxPAPA) to investigate the role of polar head groups in EC barrier-protective responses to oxidized phospholipids (OxPLs). OxPAPC and OxPAPS induced sustained barrier enhancement in pulmonary EC, whereas OxPAPA caused a transient protective response as judged by measurements of transendothelial electrical resistance (TER). Non-OxPLs showed no effects on TER levels. All three OxPLs caused enhancement of peripheral EC actin cytoskeleton. OxPAPC and OxPAPS completely abolished LPS-induced EC hyperpermeability in vitro, whereas OxPAPA showed only a partial protective effect. In vivo, intravenous injection of OxPAPS or OxPAPC (1.5 mg\/kg) markedly attenuated increases in the protein content, cell counts, and myeloperoxidase activities detected in bronchoalveolar lavage fluid upon intratracheal LPS instillation in mice, although OxPAPC showed less potency. All three OxPLs partially attenuated EC barrier dysfunction induced by IL-6 and thrombin. Their protective effects against thrombin-induced EC barrier dysfunction were linked to the attenuation of the thrombin-induced Rho pathway of EC hyperpermeability and stimulation of Rac-mediated mechanisms of EC barrier recovery. These results demonstrate for the first time the essential role of polar OxPL groups in blunting the LPS-induced EC dysfunction in vitro and in vivo and suggest the mechanism of agonist-induced hyperpermeability attenuation by OxPLs via reduction of Rho and stimulation of Rac signaling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16208769,"openaccessinfo":{"externalids":{"MAG":"2029742023","ACL":null,"DOI":"10.1152\/AJPLUNG.00395.2006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The uniaxial compressive strength (UCS) of intact rocks is one of the key parameters in the course of site characterizations. The isotropy\/anisotropy condition of the UCS of intact rocks is dependent on the internal structure of the rocks. The rocks with a random grain structure exhibit an isotropic behavior. However, the rocks with a linear\/planar grain structure generally behave transversely-isotropic. In the latter case, the UCS of intact rocks must be determined by a set of laboratory tests on the oriented rock samples. There are some empirical relations available to describe the strength of these rocks. Though characterization of transversely-isotropic rocks is practically a 3D problem, but these relations provide only a 2D description. In this paper, a method is proposed to provide a 3D description of UCS of transversely-isotropic rocks. By means of this formulation, one can determine UCS along with any arbitrary spatial direction. Also, a representative illustration of UCS is proposed in the form of contour-plots on a lower hemisphere Stereonet. The method is applied to an actual case study from the Kanigoizhan dam site located in the Kurdistan Province (Iran). Application of the proposed method to the phyllite rocks of this site show that the direction perpendicular to the dam axis exhibits the most anisotropic behavior. Hence, it is essential to take the strength anisotropy into account during the relevant analysis. The results obtained, together with the statistical variation of UCS, provide a practical approach to select the proper values of UCS according to the scope of the analysis.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1,"unknown":2}},"corpusid":221676804,"openaccessinfo":{"externalids":{"MAG":"3086290297","ACL":null,"DOI":"10.22044\/JME.2020.9039.1791","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Edge plasma features in typical HL-1M discharges were presented. Particle confinement and plasma rotation have been investigated in the discharges with lower hybrid current drive (LHCD), molecular beam injection (MBI) and pellet fuelling. LHCD can make particle confinement increase a factor of 2-3 for low-density discharge. Particle confinement time and poloidal rotation can be at least doubled after pellet injection, while MBI can make confinement time increase about one order of magnitude with higher performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250822650,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1009-0630\/1\/1\/003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The University of Missouri-Rolla identified materials that permit the safe, reliable and economical operation of combined cycle gasifiers by the pulp and paper industry. The primary emphasis of this project was to resolve the material problems encountered during the operation of low-pressure high-temperature (LPHT) and low-pressure low-temperature (LPLT) gasifiers while simultaneously understanding the materials barriers to the successful demonstration of high-pressure high-temperature (HPHT) black liquor gasifiers. This study attempted to define the chemical, thermal and physical conditions in current and proposed gasifier designs and then modify existing materials and develop new materials to successfully meet the formidable material challenges. Resolving the material challenges of black liquor gasification combined cycle technology will provide energy, environmental, and economic benefits that include higher thermal efficiencies, up to three times greater electrical output per unit of fuel, and lower emissions. In the near term, adoption of this technology will allow the pulp and paper industry greater capital effectiveness and flexibility, as gasifiers are added to increase mill capacity. In the long term, combined-cycle gasification will lessen the industry's environmental impact while increasing its potential for energy production, allowing the production of all the mill's heat and power needs along with surplus electricity being returned to the grid. An added benefit will be the potential elimination of the possibility of smelt-water explosions, which constitute an important safety concern wherever conventional Tomlinson recovery boilers are operated. Developing cost-effective materials with improved performance in gasifier environments may be the best answer to the material challenges presented by black liquor gasification. Refractory materials were selected or developed that reacted with the gasifier environment to form protective surfaces in-situ; and were functionally-graded to give the best combination of thermal, mechanical and physical properties and chemical stability; and are relatively inexpensive, reliable repair materials. Material development was divided into 2 tasks: Task 1 was development and property determinations of improved and existing refractory systems for black liquor containment. Refractory systems of interest include magnesium aluminate and barium aluminate for binder materials, both dry and hydratable, and materials with high alumina contents, 85-95 wt%, aluminum oxide, 5.0-15.0 wt%, and BaO, SrO, CaO, ZrO2 and SiC. Task 2 was finite element analysis of heat flow and thermal stress\/strain in the refractory lining and steel shell of existing and proposed vessel designs. Stress and strain due to thermal and chemical expansion has been observed to be detrimental to the lifespan of existing black liquor gasifiers. The thermal and chemical strain as well as corrosion rates must be accounted for in order to predict the lifetime of the gasifier containment materials.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":202179746,"openaccessinfo":{"externalids":{"MAG":"2969287130","ACL":null,"DOI":"10.2172\/885489","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/biblio\/885489","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"To the Editor.\u2014 The MEDICAL NEWS item, \"In the Hot Seat: Thermography for Breast Cancer Diagnosis,\" published in the Feb 10,1984, issue ofThe Journal, 1 deserves additional attention and comment. The pejorative tenor of both the report and the strongly worded policy statement of the American College of Radiology does a disservice to American women as well as to your readers. In a recent issue of CA: A Cancer Journal for Clinicians , Gerald D. Dodd, Jr, MD, 2 credited by MEDICAL NEWS as the spokesman for the American College of Radiology, notes that it took 30 years of neglect and 20 years of controversy before the initial considerable resistance by radiologists to the adoption of x-ray mammography was overcome and the technique was ultimately accepted. It appears that in 1984 the reluctant attitude of some of my radiological colleagues may be responsible for consigning breast thermography to a similar","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":43317629,"openaccessinfo":{"externalids":{"MAG":"2044664802","ACL":null,"DOI":"10.1001\/JAMA.1985.03350250049015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper discusses the use of Field-Programmable Gate Arrays (FPGAs) -based embedded systems to enhance the cyber security of microgrid infrastructure. This may be obtained by shifting the center of critical algorithms execution outside the main processing unit of the target components. The use of FPGAs allow various specific implementation approaches. The modern SoC architectures containing both an FPGA component and an advanced processing system in the same chip might be one of the answers to the cybernetic security enhancement. This solution can be the key in the evolving measurement and control systems used in microgrid terminals and\/or data processing points. By narrowing the range of commonly known cyber-attacks, this may represent one of the best solutions to boost the cybernetic security of the measurement and control systems.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":2}},"corpusid":258378853,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ATEE58038.2023.10108304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"UNLABELLED\nThe object is the relationship between the professionalization of Brazilian nursing and women, in the broadcasting of news about the creation of the Professional School of Nurses, in the light of gender.\n\n\nAIMS\nto discuss the linkage of women to the beginning of the professionalization of Brazilian nursing following the circumstances and evidence of the creation of the Professional School of Nurses analyzed from the perspective of gender. The news articles were analyzed from the viewpoint of Cultural History, founded in the gender concept of Joan Scott and in the History of Women. The creation of the School and the priority given in the media to women consolidate the vocational ideal of the woman for nursing in a profession subjugated to the physician but also representing the conquest of a space in the world of education and work, reconfiguring the social position of nursing and of woman in Brazil.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37014922,"openaccessinfo":{"externalids":{"MAG":"1665868120","ACL":null,"DOI":"10.1590\/S0104-11692011000500026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was carried out under the aegis of the program Surface Water and Ocean Topography (SWOT) associated with the National Center of Space Studies (CNES). The future SWOT mission will offer new opportunities to survey the hydrodynamic in the rivers because it will provide data on the water level\/ discharges with a high spatial resolution (oceans: 1 km, rivers: 100 m of width) and with a global cover. However, it is important to estimate the capacity of SWOT to reproduce the hydrodynamic phenomena in the estuaries and the temporal and the spatial variability of this dynamic. The aim of this paper is 1) to estimate the capacity of SWOT to reproduce the hydrological variability of watersheds, and 2) to validate the use of these data for other zone without hydrometric station. Based on discharge measurements and simulated Surface Water and Ocean Topography (SWOT) data, we have investigated the hydrological variability of the main French rivers (Seine, Loire, Garonne and Rh?ne) by applying a series of statistical analyses to the discharge time series. A frequency analysis has been also used using a technique of wavelet. Results have shown a similar hydrological variability of the four watersheds. Three different periods of hydrologic variability has been identified: before 1970, between 1970 and 1990, and after 1990. Using these analyses, simulated SWOT samples and discharges were compared during the three studied periods. Simulated SWOT data, obtained by a synthetic sampling of river discharges basing on the number of measurements per repeat orbit, reproduce the hydrological variability of rivers. Such reproduction seems to be independent in the number of SWOT passages (from two to four), except for the minimum and maximum annual discharges where number of overpass seems to have an influence. These results were validated by coherence wavelet which underlines coherence higher than 90% between simulated SWOT data and in-situ discharges. Nevertheless, good correlation was not observed for the minimum and the maximum annual discharge with an underestimation for SWOT maximum annual and an overestimation of the minimum annual SWOT ones. Moreover, best identification of minimum, mean and maximum annual discharge depends on SWOT overpasses.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":134494298,"openaccessinfo":{"externalids":{"MAG":"2779853635","ACL":null,"DOI":"10.4236\/GEP.2017.513004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Some intricate problems of the Buryat-English translation are considered, particularly the translation of paired words, repetitions, causatives. Onomatopoetical words, i. e. the use of imitative and naturally suggestive words for rhetoric effect are also given attention to as well as phonaesthetic words. Paradigmatic and syntagmatic interrelationship is under review. The method for system analysis and classification has been discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":147367440,"openaccessinfo":{"externalids":{"MAG":"2267472155","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTIONConsumer buying behavior has changed considerably with the substantial growth of the Internet. Word-of-mouth now often takes the form of online ratings made by users of a product. Online reviews of products are available for many products from hotels to books (Zhang et al., 2010) and a major source of information for product purchases (Liu, 2006). With this increasing availability of ratings, researchers have begun to use rating information, especially average user ratings, typically referred to as valence, in many ways. For movies, valence has often been related to sales with some finding valence predicts sales (Dellarocas & Zhang, 2007) and others finding no relationship between the two (Chintagunta, Gopinath, & Venkataraman, 2010).While it is possible this difference in results is due to differences in the movies considered (Purnawirawan et al., 2015), it is also possible investigators should not so quickly assume user ratings are reliable and valid sources of information or sites presumably measuring quality are valid for the same purposes. Further, as consistency across sites decreases, it can suggest low reliability which can lower the correlation between such ratings and criteria under investigation because the power to discover relationships is weakened (Nunnally, 1978, Traub, 1994) or it can suggest the validity of the ratings is not strong or the measures reflect different quality dimensions (Kline, 1993).These problems are, in part, due to the nature of online ratings. They are not collected in controlled settings and the rating scales used can sometimes be weak. None have been developed for the purpose of academic research. Though the focus of this study is on movies, these weaknesses can foster random measurement error and result in rating inconsistency and validity problems across database sources for books, computers, or any other product. Generally, there is very little research on the cross-platform rating consistency and validity of user ratings.PRIOR RESEARCHThe reliability of movie ratings has been a concern for quite some time and the results have varied. Cosley et al. (2003) found test-retest reliability to be relatively strong at .70 for 40 randomly selected movies rated by viewers over time, suggesting at least that users agree with their own ratings. Similarly, Amatriain, Pujol, and Oliver (2009) found strong test-retest reliability of .88 for 100 movies rated a second time at least 15 days from when first rated.Thus, it appears users agree with themselves over time, but this is not the same as two users agreeing across two different rating platforms. It is possible for individual ratings to be reliable in a test-retest sense, but for users to differ. For example, agreement between movie critics has been found to be quite weak by some researchers (Agresti & Winner, 1997). Assessing the reliability of individual ratings is a good way for better understanding average ratings, but it does not assure the average ratings will be reliable or valid. And ultimately, they are the predictor of concern (Tett, Jackson, & Rothstein, 1991)One method for assessing the reliability of average ratings is to check consistency across platforms. This type of research has been infrequent and shown varying results for movies. Plucker et al. (2009) found a low-moderate correlation of .43 between mean ratings by students and critics. However, they found a moderate correlation of .65 between mean student ratings and mean user ratings on both the IMDb and boxofficemojo.com sites.One factor that seems to affect the consistency of mean ratings across users is user experience. For students who rarely saw movies, their average rating showed a low correlation in the Plucker et al. study (2009) of .22 with mean critic ratings and .30 and .29 for mean ratings on the IMDb and boxofficemojo.com platforms, respectively. However, the correlation between mean student ratings and mean critic ratings increased to . \u2026","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152025634,"openaccessinfo":{"externalids":{"MAG":"2589156760","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study evaluated food intake and productive performance of crossbred (\u00bd Santa Ines x \u00bd dorper) lambs supplemented with different levels of faveleira ( Cnidoscolus quercifolius Pohl) fodder salt. Thirty male sheep fed tifton grass hay, water, and faveleira fodder salt were randomly allocated into five treatments with six replicates each. The treatments consisted of diets with different inclusion levels of faveleira hay in the fodder salt composition: Treatment 1 (1% mineral salt + 99% faveleira hay), Treatment 2 (3% mineral salt + 97% faveleira hay), Treatment 3 (5% mineral salt + 95% faveleira hay), Treatment 4 (7% mineral salt + 93% faveleira hay), and Treatment 5 (Control - 100% mineral salt). Intake of dry matter, tifton hay and water, average daily gain, feed conversion, and feed efficiency were not affected by fodder salt supplementation (P > 0.05). There was a significant difference (P < 0.05) in fodder salt intake between Treatments 4 and 5, and daily intake was higher in animals submitted to Treatment 4 (61.0 g day-1). Mineral salt intake increased significantly with increasing mineral salt levels in the diet. However, no significant difference was observed in average daily gain across treatments, indicating that faveleira hay, even in small quantities, and tifton hay were able to meet the nutritional requirements of animals to support a good average daily gain. The inclusion of up to 99% faveleira hay in fodder salt formulations did not affect voluntary intake of forage, water and dry matter, average daily gain, feed conversion, and feed efficiency. Lambs supplemented with faveleira fodder salt had average daily gains within the optimal range for slaughter and high feed conversion and feed efficiency values. Faveleira was shown to be an effective supplementary feed alternative in sheep.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":59522160,"openaccessinfo":{"externalids":{"MAG":"2342898527","ACL":null,"DOI":"10.5433\/1679-0359.2016V37N2P977","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors present the results of measurements of the AC transport (self-field) and magnetic losses on silver sheathed (Bi,Pb)SrCaCuO-2223 tapes prepared by the powder in tube method. In the frequency range 30-540 Hz the transport current losses are hysteretic in nature. Losses arising from AC external magnetic field (frequency range 65-207 Hz, amplitude up to 60 mT) are compared with losses generated by AC transport currents. The measured transport loss voltage depends strongly on the position of the potential taps on the surface of the tapes. Losses due to combined AC applied magnetic fields and transport currents are also reported.<>","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11967816,"openaccessinfo":{"externalids":{"MAG":"2099554396","ACL":null,"DOI":"10.1109\/77.402646","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Generally, it has been considered that the Ural Owl Strix uralensis feeds mainly on small birds, amphibians and small mammals such as voles, and only rarely on insects. However, we found that the Ural Owl often preys upon the Japanese horned beetle Trypoxylus dichotomus septentrionalis, which has never before been reported as an insect prey species for the Ural Owl. We here demonstrate that Ural Owls at the present study site frequently prey upon Japanese horned beetles for a limited period during summer. Details of the predatory behavior of Ural Owls upon beetles are also given.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":87023027,"openaccessinfo":{"externalids":{"MAG":"2326184151","ACL":null,"DOI":"10.3312\/JYIO.40.90","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We analyze within a dynamic model how firms decide on capital investment if the accompanying adjustment costs are a function of governmental activity. The government provides a public input and decides on the degree of rivalry. The productive public input enhances private capital productivity and reduces adjustment costs. We derive the equilibrium in which capital and investment ratio are both constant, carry out comparative dynamic analysis and discuss the model's policy implications. Increasing the amount of the public input unequivocally spurs capital investment whereas the result becomes ambiguous with respect to the impact of rivalry. Since a reduction in congestion increases the individually available amount of the public input, crowding out effects may lead to a reduction in the equilibrium capital stock. Most of the analysis is conducted for general production functions, although the case of CES technology is also considered.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":153578373,"openaccessinfo":{"externalids":{"MAG":"1604510884","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, three polymeric fibers (nylon 66, polypropylene, and acrylic) were used to improve the flexural and tension strength of cementitious materials. To characterize the performance of these fibers in a cement matrix, scanning electron microscopy, optical microscopy, dynamic mechanical analysis, tensile strength testing, and alkali resistance test were employed. The performance of cement-based composites containing the fibers was evaluated with a flexural strength test. The results indicated that the flexural strength increased with an increasing number of interfacial interactions between the fibers and cement. This finding was supported by dynamic mechanical analysis data. This has great application potential for fibers. \u00a9 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":136777743,"openaccessinfo":{"externalids":{"MAG":"2034073899","ACL":null,"DOI":"10.1002\/APP.30302","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Energy consumption data is being used for improving the energy efficiency and minimizing the cost. However, obtaining energy consumption data has two major challenges: (i) data collection is very expensive, time-consuming, and (ii) security and privacy concern of the users which can be revealed from the actual data. In this research, we have addressed these challenges by using generative adversarial networks for generating energy consumption profile. We have successfully generated synthetic data which is similar to the real energy consumption data. On the basis of the recent research conducted on TimeGAN, we have implemented a framework for synthetic energy consumption data generation that could be useful in research, data analysis and create business solutions. The framework is implemented using the real-world energy dataset, consisting of energy consumption data of the year 2020 for the Australian states of Victoria, New South Wales, South Australia, Queensland and Tasmania. The results of implementation is evaluated using various performance measures and the results are showcased using visualizations along with Principal Component Analysis (PCA) and t-distributed stochastic neighbor embedding (TSNE) plots. Overall, experimental results show that Synthetic data generated using the proposed implementation possess very similar characteristics to the real dataset with high comparison accuracy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":246316534,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/electronics11030355","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2079-9292\/11\/3\/355\/pdf?version=1643448279","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Chlorinated ethenes (CEs) such as perchloroethylene, trichloroethylene and dichloroethylene are notorious groundwater contaminants. Although reductive dehalogenation is key to their environmental and engineered degradation, underlying reaction mechanisms remain elusive. Outer-sphere reductive single electron transfer (OS-SET) has been proposed for such different processes as Vitamin B12-dependent biodegradation and zerovalent metal-mediated dehalogenation. Compound-specific isotope effect (13C\/12C, 37Cl\/35Cl) analysis offers a new opportunity to test these hypotheses. Defined OS-SET model reactants (CO2 radical anions, S2--doped graphene oxide in water) caused strong carbon (\u03b5C = -7.9\u2030 to -11.9\u2030), but negligible chlorine isotope effects (\u03b5Cl = -0.12\u2030 to 0.04\u2030) in CEs. Greater chlorine isotope effects were observed in CHCl3 (\u03b5C = -7.7\u2030, \u03b5Cl = -2.6\u2030), and in CEs when the exergonicity of C-Cl bond cleavage was reduced in an organic solvent (reaction with arene radical anions in glyme). Together, this points to dissociative OS-SET (SET to a \u03c3* orbital concerted with C-Cl breakage) in alkanes compared to stepwise OS-SET (SET to a \u03c0* orbital followed by C-Cl cleavage) in ethenes. The nonexistent chlorine isotope effects of chlorinated ethenes in all aqueous OS-SET experiments contrast strongly with pronounced Cl isotope fractionation in all natural and engineered reductive dehalogenations reported to date suggesting that OS-SET is an exception rather than the rule in environmental transformations of chlorinated ethenes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206569399,"openaccessinfo":{"externalids":{"MAG":"2736348540","ACL":null,"DOI":"10.1021\/acs.est.7b01447","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The present study aimed to investigate the inhibitory effect of alcoholic extract (methanol - ethanol) and flavonoids by diffusion\u00a0 methods of wells of Salvia officinalis L. and Costus speciosus L. plants on Escherichia . coli and Proteus \u00a0spp. isolated from patients with urinary tract infection Samarra city, the samples were collected during the period from 15\/7\/2018 to 30\/9\/2018, It was found through the results that the extracts plant that used in this study showed various inhibitory effect against, The bacteria species study imitation , where on differ this effect by difference the concentration that used and type the plant extract , showing\u00a0 E.coli significant difference at significant (p< 0.05) in inhibition diameter of alcoholic (methanol) extract for Salvia officinalis L. (10.61\u00b17.5) at higher concentration used, while these bacteria showed on significant difference in the level of inhibition diameter of alcoholic (ethanolic) extract for Salvia officinalis L., whereas the flavonoids Netted significant difference of these plant in some of concentration that used comparied with the antibiotic that used in this study. Either regarding proteus spp. bacteria notted no significant difference of both the Costus speciosus L. and Salvia officinalis L. by using the alcoholic (ethanolic) extract, while the flavonoids extract showed no significant difference in Costus speciosus L., whereas showed high significant difference in flavonoids extract of Salvia officinalis\u00a0 L., due to the fact that the flavonoids extract is one of the active substance that done laboratory extraction for both the plants where that higher inhibitory effect of microbial growth from the alcoholic (ethanolic \u2013 methanolic) extract of plants .\u00a0 \n\u00a0 \nhttp:\/\/dx.doi.org\/10.25130\/tjps.25.2020.009","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219137863,"openaccessinfo":{"externalids":{"MAG":"3018295928","ACL":null,"DOI":"10.25130\/j.v25i1.933","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.25130\/j.v25i1.933","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"How to construct a tele-manipulation system of a robot arm with both visual and haptic sensation is shown together with the experimental result. To move a robot arm at a slave system as an operator intends, he manipulates a force feedback device (PHANTOM) at a master system while watching a television image of the robot arm taken at the slave system. A force torque sensor (FTS: a force torque sensor and FT data: the output data of FTS) is mounted on a robot hand, and the output is conveyed to the PHANToM. This system gives a user the feeling as if he were directly operating the remote robot arm. However the following problems occur in operation. (1) The difference between the state of a robot and that indicated in a television (2) The delay caused the output of FTS to the PHANToM (3) It is difficult to synchronize the TV image with the force returned with a PHANToM. We propose two techniques to solve these problems, and show their effects in detail.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":62175224,"openaccessinfo":{"externalids":{"MAG":"2121418302","ACL":null,"DOI":"10.1109\/VSMM.2001.969702","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Eddy covariance has been used in urban areas to evaluate the net exchange of CO2 between the surface and the atmosphere. Typically, only the vertical flux is measured at a height 2e3 times that of the local roughness elements; however, under conditions of relatively low instability, CO2 may accumulate in the airspace below the measurement height. This can result in inaccurate emissions estimates if the accumulated CO2 drains away or is flushed upwards during thermal expansion of the boundary layer. Some studies apply a single height storage correction; however, this requires the assumption that the response of the CO2 concentration profile to forcing is constant with height. Here a full seasonal cycle (7th June 2012 to 3rd June 2013) of single height CO2 storage data calculated from concentrations measured at 10 Hz by open path gas analyser are compared to a data set calculated from a concurrent switched vertical profile measured (2 Hz, closed path gas analyser) at 10 heights within and above a street canyon in central London. The assumption required for the former storage determination is shown to be invalid. For approximately regular street canyons at least one other measurement is required. Continuous measurements at fewer locations are shown to be preferable to a spatially dense, switched profile, as temporal interpolation is ineffective. The majority of the spectral energy of the CO2 storage time series was found to be between 0.001 and 0.2 Hz (500 and 5 s respectively); however, sampling frequencies of 2 Hz and below still result in significantly lower CO2 storage values. An empirical method of correcting CO2 storage values from under-sampled time series is proposed. \u00a9 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/).","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":3670956,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Propoxur (Baygon, 2-isopropoxyphenyl N-methylcarbamate) is a carbamate pesticide commonly used against house insects. When the insecticide was administered intramuscularly in rats it was converted to a new metabolite which was found to be present in the serum, liver, kidney and brain 6 h after the administration of the pesticide. The metabolite was purified by high performance liquid to chromatography and comparison of the infrared spectra of Propoxur and the metabolite showed that a deamination reaction was responsible for the formation of the metabolite from the parent pesticide. The pesticide also induced haematological changes such as an increased level of total bilubrin, amylase and glutamic-oxalacetic transaminase and decrease of cholinesterase activity, indicating damage of the liver and nervous system in rats.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30602787,"openaccessinfo":{"externalids":{"MAG":"2070761880","ACL":null,"DOI":"10.1002\/BMC.1130070106","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Steady-state and transient hydrogen-sensing characteristics of a novel Pd\/InP metal-oxide-semiconductor (MOS) Schottky diode under atmospheric conditions are presented and studied. In presence of oxide layer, the significant increase of barrier height improves the hydrogen sensitivity even at lower operating temperatures. Even at a very low hydrogen concentration environment, e.g., 15 ppm H\/sub 2\/ in air, a significant response is obtained. Two effects, i.e., the removal of Fermi-level pinning caused by the donor level in the oxide and the reduction of Pd metal work function dominate the hydrogen sensing mechanism. Furthermore, the reaction kinetics incorporating the water formation upon hydrogen adsorption is investigated. The initial heat of adsorption for the Pd\/oxide interface is estimated to be 0.42 eV\/hydrogen atom. The coverage dependent heat of adsorption plays an important role in hydrogen response under steady-state conditions. In accordance with the Temkin isotherm behavior, the theoretical prediction of interface coverage agrees well with the experimental results over more than three decades of hydrogen partial pressure.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97131833,"openaccessinfo":{"externalids":{"MAG":"2100389066","ACL":null,"DOI":"10.1109\/16.944180","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Despite the 30 yr history of ultraluminous X-ray sources (ULXs) studies, issues such as the majority of their physical natures (i.e., neutron stars, stellar-mass black holes, or intermediate black holes) as well as the accretion mechanisms are still under debate. Expanding the ULX sample size in the literature is clearly a way to help. To this end, we investigated the X-ray source population, ULXs in particular, in the barred spiral galaxy NGC 1559 using a Chandra observation made in 2016. In this 45 ks exposure, 33 X-ray point sources were detected within the 2.\u20327 isophotal radius of the galaxy. Among them, eight ULXs were identified with the criterion of the X-ray luminosity L x > 1039 erg s\u22121 (0.3\u20137 keV). Both X-ray light curves and spectra of all the sources were examined. Except for some low-count spectra that only provide ambiguous spectral fitting results, all the X-ray sources were basically spectrally hard and therefore likely have nonthermal origins. While no strong X-ray variability was present in most of the sources owing to the relatively short exposure of the observation, we found an intriguing ULX, named X-24, exhibiting a periodicity of \u223c7500 s with a detection significance of 2.7\u03c3. We speculate that it is the orbital period of the system. Roche-lobe overflow and Roche limit are consistent with the speculation. Thus, we suggest that X-24 may be one of the rare compact binary ULXs, and hence, a good candidate as a stellar-mass black hole.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":260887290,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3847\/1538-4357\/aced04","PubMedCentral":null,"ArXiv":"2308.06287"},"license":"CCBY","url":"https:\/\/iopscience.iop.org\/article\/10.3847\/1538-4357\/aced04\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aiming at the improvement of the quality of synthetic speech generated by our native TTS ARTIC, we adopted the unit selection method. Our unit selection module is driven by prosody described solely by high-level symbolic features which are linked to the prosody of synthesized phrases through the phenomena of prosodic synonymy and homonymy. It was confirmed that such an approach not only generates speech with high naturalness but also keeps the richness of prosody. Our first version of this approach significantly increased the quality of the output speech, which was assessed by listeners as very close to natural. The concept of prosodic synonymy and homonymy is, therefore, further extended and formally described in this paper, and its importance to the unit selection treatment is demonstrated. In addition, the difference of this concept from the concepts most frequently used is shown. Moreover, the first experiment following the formal definition of the problem presented in this paper has been carried out, proving that the whole concept is feasible.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5725860,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Living Xiphinema americanum (Xa) and X. rivesi (Xr) extracted from soil samples and stored for 1-5 days at 4 or 20 C contained aseptate fungal hyphae. The fungi directly penetrated the nematode's cuticle from spores encysted near the head. Penetration through the stoma, vulva, or anus was rare. Catenaria anguillulae (Cat), Lagenidium caudatura (Lag), Aphanomyces sp. (Aph), and Leptolegnia sp. (Lep) were isolated into pure culture from infected nematodes. The pathogenicity of these zoosporic fungi was determined by incubating mixed freshly extracted Xa and Xr in 2% soil extract (pH = 6.7, conductivity = 48 mumhos, 20 +\/- 2 C) containing zoospores obtained from single-spore isolates. After 4 days, Cat, Lag, Aph, and Lep had infected 78, 18, 13, and 22%, respectively, of the nematodes. Both Xa and Xr were infected by every fungus; however, the relative susceptibility of Xa and Xr to these fungi was not determined. All noninoculated control nematodes remained uninfected and alive. In a second experiment, parasitism of Xa and Xr by Aph and Lep was increased when nematodes were incubated in 2% soil extract for 4 days before exposure to zoospores. In a third experiment, parasitism of Xa and Xr by Cat was greater in diluted saturation soil extract (conductivity = 100-400 mumhos) than in undiluted saturation extract (conductivity = 780 mumhos). Cat produced small zoospores (4-mum-d), bulbous infection hyphae, and assimilative hyphae of varying diameters in nematodes, whereas Lag, Aph, and Lep produced large zoospores (8-mum-d) and tubular, uniform infection and assimilative hyphae in nematodes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12006585,"openaccessinfo":{"externalids":{"MAG":"2149898019","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a preliminary study whose main aim is to characterize four distinct speaking styles according to a limited set of prosodic features, including the length of prosodic phrases (AP and IP), the distribution of stressed syllables, pitch register span, the duration of silent pauses, etc. The analysis was performed using semi-automatic procedures on a corpus consisting of 30 minutes of speech per style. The study focuses on four styles, all of which are \"overtly addressed to a given audience\", but differ as to the nature of the audience (adults vs. children) and the desired impact of the address (\"i mportance of being understood and convincing, or not\"). Data analysis reveals that (a) dictation (addressed to children) and political speeches (addressed to adults) are different to the two other speaking styles (reading of novels and fairy tales) with respect to a specific set of prosodic cues; while (b) the speeches addressed to children differ from the ones addressed to adults, with respect to another set of prosodic cues (especially pitch register span). These results have an interesting practical application: refining the design of pre-processing prosodic modules in a text-to-speech system, in order to improve the expressivity of synthesized speech.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11631366,"openaccessinfo":{"externalids":{"MAG":"2405915506","ACL":null,"DOI":"10.21437\/Interspeech.2014-409","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider an active Ising model in which spins both diffuse and align on lattice in one and two dimensions. The diffusion is biased so that plus or minus spins hop preferably to the left or to the right, which generates a flocking transition at low temperature and high density. We construct a coarse-grained description of the model that predicts this transition to be a first-order liquid-gas transition in the temperature-density ensemble, with a critical density sent to infinity. In this first-order phase transition, the magnetization is proportional to the liquid fraction and thus varies continuously throughout the phase diagram. Using microscopic simulations, we show that this theoretical prediction holds in 2D whereas the fluctuations alter the transition in 1D, preventing, for instance, any spontaneous symmetry breaking.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31788993,"openaccessinfo":{"externalids":{"MAG":"2059088263","ACL":null,"DOI":"10.1103\/PhysRevLett.111.078101","PubMedCentral":null,"ArXiv":"1303.4427"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective To investigate the impact of Alzheimer's disease (AD)-related risk gene (ATP-binding cassette A7-ABCA7 and Clusterin-CLU) on the functional connectivity pattern of default mode network (DMN) in healthy middle-age adults. Methods A total of 147 healthy middle-aged volunteers were enrolled in this study. All subjects completed MRI scans, neuropsychological assessments, and AD-related genotyped analysis. All subjects were divided into high, middle and low risk groups according to the score of risk genotypes, which included CLU (rs11136000, rs2279590, rs9331888, and rs9331949) and ABCA7 (rs3764650 and rs4147929). The genetic effects of CLU, ABCA7, and CLU \u00d7 ABCA7 on DMN functional connectivity pattern were further explored. Moreover, the genetic effect of Apolipoprotein \u03b54 (APOE\u03b54) was also considered. Finally, correlation analysis was performed between the signals of brain regions with genetic effect and neuropsychological test scores. Results Compared with the low-risk group, the high-risk group of CLU showed decreased functional connectivity in posterior cingulate cortex (PCC) and the left middle frontal cortex (P < 0.05, GRF correction). As for the interaction between the CLU and ABCA7, all the subjects were divided into high, middle, and low risk group; the middle-risk group was divided into CLU and ABCA7-dominated middle-risk group. The function connectivity pattern of DMN among the three or four groups were distributed in the bilateral medial prefrontal cortex (MPFC) and bilateral superior frontal gyrus (SFG) (P < 0.05, GRF correction). When APOE\u03b54 carriers were excluded, the CLU-predominant middle-risk group displayed the decreased functional connectivity in MPFC when compared with the low-risk group, while ABCA7-prodominant middle-risk group displayed decreased functional connectivity in cuneus when compared with the high-risk group (all P < 0.05, GRF correction). The z values of left middle frontal cortex were positively correlated with the scores of Serial Dotting Test (SDT) in high-risk group of CLU, while z values of MPFC and cuneus were positively correlated to the scores of Montreal Cognitive Assessment (MoCA) in low-risk group of three or four groups. Conclusion The functional connectivity of MPFC-PCC might be modulated by the interaction of CLU and ABCA7. Moreover, APOE\u03b54 might be interacted with ABCA7 and CLU modulation in the middle-aged carriers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220885613,"openaccessinfo":{"externalids":{"MAG":"3046279994","ACL":null,"DOI":"10.3389\/fnmol.2020.00145","PubMedCentral":"7412986","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnmol.2020.00145\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"One of the priorities ofeconomic structure reform is budget reform methods and distribution of references in government organizations. Operational budgeting as a new budgeting method has emphasized on the importance of identifying the measurable results from public spending and could give a certain transparency to budgeting process in governmentalorganizations and increases despondence to objectives of organizational initiatives. Given the importance of operational budgeting, this research was done with the aim of studying the problems and obstacles of operational budgeting in department of ports and maritime in Khuzestan province. data collected in this study is questionnaire. Hypotheses of the study have been tested using t-test of a sample. Based on the findings, lack of skilled manpower for training and implementation of operational budgeting, lack of holding, or lack of appropriate training courses and related operational budgeting for staff, lack of efficiency and productivity for the implementation of operational budgeting systems by administrators, high costs for implementation of operational budgeting are some barriers to the establishment of operational budgeting in Director General of ports and Maritime in Khuzestan province. But overall, none of the human, management and structural factors are considered as a serious obstacle to the establishment of the operational budgeting in Director General of Ports and Maritime, Khuzestan province.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":218383067,"openaccessinfo":{"externalids":{"MAG":"2279070394","ACL":null,"DOI":"10.5958\/2249-6270.2015.00029.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The paper is concerned with transmission of MPEG video over a Bluetooth wireless network using fuzzy controllers. MPEG variable bit rate (VBR) data sources are unpredictable and have substantial variations in bit rate. Subsequently, it is almost impossible to transmit the VBR data sources over a Bluetooth channel with a limited transmission speed of up to 723.2 kb\/s and wireless interference, without data loss or image quality degradation. To resolve this problem, a traffic-shaping buffer is introduced before the host controller interface (HCI). In Bluetooth, the traffic-shaping buffer prevents excessive back-to-back cells being generated during the peak transmissions of MPEG VBR data sources. We use a fuzzy controller to adjust the traffic-shaping buffer output rate to enable the VBR encoded video to conform to the current situation in the Bluetooth channel. Another fuzzy controller regulates the average arrival rate to the traffic-shaping buffer to prevent either overflow or starvation of the buffer. Computer simulation results demonstrate that the use of fuzzy controllers reduces excessive delay and data loss at the HCI as compared with conventional video transmission in Bluetooth.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2377439,"openaccessinfo":{"externalids":{"MAG":"2143695346","ACL":null,"DOI":"10.1109\/CCNC.2004.1286918","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cervical cancer is always preceded by epithelial lesions which have larger and more densely spaced nuclei than normal tissue. Detecting and removing these lesions prevents the development of cervical cancer. A proposed method to detect precancerous lesion in vivo is to use the nuclear size and density information from fiber optic confocal images of the cervical epithelial tissue to classify the tissue as normal or precancerous. Automatically segmenting nuclei is challenging because they are hard to decipher from the noise in the confocal images. This paper outlines an algorithm to automatically segment cervical epithelial nuclei from fiber optic confocal videos using Gaussian Markov random fields. Gaussian Markov random fields segment images with additive Gaussian noise by modeling the underlying structure of the image. The algorithm described in this paper detects 90% of the nuclei in each frame with a 14% error rate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2755426,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The current study aims to explore the prediction use of English language learning strategies based on personality traits among female university level learners of English language as a university major subject at Islamic Azad University in Iran. Four instruments were used, which were the Strategy Inventory for Language Learning (SILL) of Rebecca L. Oxfords, A Background Questionnaire, the NEO-Five Factors Inventory (NEO-FFI), and the Test of English as a Foreign Language (TOEFL). Two hundred and thirteen Iranian female students volunteered to participate in this research study. The intact classes were chosen. The obtained results in this study show that the Conscientiousness trait and the Extraversion trait best predicted the overall use of Memory strategies of the students, and the Openness to Experiences trait and the Conscientiousness trait best predicted the overall use of Cognitive strategies, Compensation strategies, Metacognitive strategies, Affective strategies, and Social strategies of the learners.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152264766,"openaccessinfo":{"externalids":{"MAG":"2518259293","ACL":null,"DOI":"10.17485\/IJST\/2012\/V5I8\/30543","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Random forests remain among the most popular off-the-shelf supervised learning algorithms. Despite their well-documented empirical success, however, until recently, few theoretical results were available to describe their performance and behavior. In this work we push beyond recent work on consistency and asymptotic normality by establishing rates of convergence for random forests and other supervised learning ensembles. We develop the notion of generalized U-statistics and show that within this framework, random forest predictions can potentially remain asymptotically normal for larger subsample sizes than previously established. We also provide Berry-Esseen bounds in order to quantify the rate at which this convergence occurs, making explicit the roles of the subsample size and the number of trees in determining the distribution of random forest predictions.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":209942194,"openaccessinfo":{"externalids":{"MAG":"2982230223","ACL":null,"DOI":"10.1214\/21-ejs1958","PubMedCentral":null,"ArXiv":"1905.10651"},"license":"CCBY","url":"https:\/\/projecteuclid.org\/journals\/electronic-journal-of-statistics\/volume-16\/issue-1\/Rates-of-convergence-for-random-forests-via-generalized-U-statistics\/10.1214\/21-EJS1958.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Once thought rare, liver disease is an emerging cause of significant morbidity and mortality. The rising burden of liver disease necessitates a competent workforce to deliver quality healthcare to patients with liver diseases. Staging liver diseases is essential in disease management. Transient elastography as compared with liver biopsy, the gold standard in staging of the disease, has gained wide acceptance in this field. This study examines the diagnostic accuracy of nurse-led transient elastography in staging fibrosis in chronic liver diseases at a tertiary referral hospital. Audit of records to locate transient elastography and liver biopsy performed within 6 months of interval yielded 193 cases for this retrospective study. A data abstraction sheet was prepared for extracting the relevant data. The content validity index and reliability of the scale were above 0.9. The diagnostic accuracy of liver stiffness evaluation (in kPa) by nurse-led transient elastography to grade fibrosis was categorized as \"significant and advanced\" and tested against the Ishak staging of liver biopsy. SPSS v.25 was used to perform the analysis. All tests were two-sided at a .01 level of significance. Area under the receiver operating characteristic curve, a graphical plot, illustrated the diagnostic ability of nurse-led transient elastography for significant fibrosis as 0.93 (95% confidence interval [CI] 0.88\u20130.99; p < .001) and advanced fibrosis as 0.89 (95% CI 0.83\u20130.93; p < .001). Spearman's \u03c1 correlation between liver stiffness evaluation and liver biopsy was significant (p = .01). Nurse-led transient elastography showed a significant diagnostic accuracy in staging hepatic fibrosis irrespective of the etiology of chronic liver disease. Given the increase in chronic liver disease, introducing more such nurse-led clinics increases the potential for early detection and improves care outcomes for this population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257403332,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/SGA.0000000000000707","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Hormonotherapy with Tamoxifen (Tam) is one of the main strategies used world-wide for the treatment of estrogen receptor positive breast cancer. However, partial responses, tumor recurrence and acquired resistance to Tam may involve mechanisms unrelated to Estrogen Receptors (ER). Studies on non-ER related mechanisms of action of Tam led us to find that it induced breast cancer cell differentiation and death through the modulation of sterol metabolism and the stimulation of sterol oxidation (de Medina et al, Cell Death Differ, 2009), and that Tam inhibited cholesterol epoxide hydrolase (ChEH). ChEH catalyzes the trans hydration of cholesterol-5,6-epoxides (CE) and this activity is a property of the microsomal antiestrogen binding site (AEBS) (de Medina et al, PNAS, 2010). In the present study we report that Tam and AEBS ligands stimulated the oxidation of cholesterol into CE and induced the accumulation of CE in MCF-7 cells through the inhibition of ChEH at therapeutic concentrations. Since CE has been reported to be a modulator of Liver-X-Receptors (LXR), we investigated the impact of Tam and other AEBS ligands on LXR-dependent gene expression: Tam and AEBS ligands modulated the expression LXR-dependent genes in MCF-7 cells. This effect had a 24 to 48 hour lag time while the effect of direct LXR modulators was observable after 6 hours, suggesting an indirect action of AEBS ligands. The involvement of CE in the control of transcription by Tam and AEBS ligands was supported by the observation that vitamin E, which inhibited the formation and the accumulation of CE, totally blocked this transcriptional modulation. We found that knocking down LXR-\u03b1 using interfering RNAs in MCF-7 cells blocked the transcriptional modulation of LXR-controlled genes induced by CE, Tam and AEBS ligands. Finally, we found that the knock down of LXR-\u03b1 reproduced the vitamin E inhibition of the induction of differentiation and death of MCF-7 cells. Altogether, these data showed that LXR-\u03b1 is implicated in the anticancer action of Tam and identified a new signaling pathway that could explain sensitivity and resistance to Tam. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 956. doi:1538-7445.AM2012-956","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":87405854,"openaccessinfo":{"externalids":{"MAG":"2945961935","ACL":null,"DOI":"10.1158\/1538-7445.AM2012-956","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A new, indirect marker of human tumour has been tested in 98 patients with urothelial bladder carcinoma. The marker is detected by B5, a monoclonal antibody which agglutinates erythrocytes from tumour-bearing patients. Patients admitted for cystoscopy for diagnosis of bladder tumour, or for follow-up of known disease, were chosen to enable comparison between (a) B5 results and (b) visual assessment of tumour growth. Ninety per cent of those with new tumour (20) and, overall, 80% of patients with tumour (74), were B5 positive. These results were independent of tumour size and include very small recurrences, implying that B5 is a sensitive marker of tumour presence. The background incidence of B5 positive individuals is 18% in controls; a similar incidence occurs in patients who have been tumour-free for 9 months or more. Patients who had no visible tumour in this study, but who had tumour within 9 months, were often B5 positive (6\/11). This may be due to the lifespan of erythrocytes causing a delay in change from B5 positive to B5 negative in those patients who will remain disease-free.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6234987,"openaccessinfo":{"externalids":{"MAG":"3147794566","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"How complicated is the relationship between a protein's sequence and its function? High-order epistatic interactions among residues are thought to be pervasive, making a protein's function difficult to predict or understand from its sequence. Most prior studies, however, used methods that misinterpret measurement errors, small local idiosyncracies around a designated wild-type sequence, and global nonlinearity in the sequence-function relationship as rampant high-order interactions. Here we present a simple new method to jointly estimate global nonlinearity and specific epistatic interactions across a protein's genotype-phenotype map. Our reference-free approach calculates the effect of each amino acid state or combination by averaging over all genotypes that contain it relative to the global average. We show that this method is more accurate than any alternative approach and is robust to measurement error and partial sampling. We reanalyze 20 combinatorial mutagenesis experiments and find that main and pairwise effects, together with a simple form of global nonlinearity, account for a median of 96% of total variance in the measured phenotype (and > 92% in every case), and only a tiny fraction of genotypes are strongly affected by epistasis at third or higher orders. The genetic architecture is also sparse: the number of model terms required to explain the vast majority of phenotypic variance is smaller than the number of genotypes by many orders of magnitude. The sequence-function relationship in most proteins is therefore far simpler than previously thought, and new, more tractable experimental approaches, combined with reference-free analysis, may be sufficient to explain it in most cases. Significance Statement It is widely thought that a protein's function depends on complex interactions among amino acids. If so, it would be virtually impossible to predict the function of new variants, and understanding how proteins work genetically and biochemically would require huge combinatorial experiments. We show that prior studies overestimated complexity because they analyzed sequence-function relationships from the perspective of a single reference genotype and\/or misinterpreted global phenotypic nonlinearities as complex amino acid interactions. By developing a new reference-free approach and using it to reanalyze 20 experimental datasets, we show that additive effects and pairwise interactions alone, along with a simple global nonlinearity, explain the vast majority of functional variation. Higher-order interactions are weak or rare, and a minuscule fraction of possible interactions shape each protein's function. Our work reveals that protein sequence-function relationships are surprisingly simple and suggests new strategies that are far more tractable than the massive experiments currently used.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":261583813,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2023.09.02.556057","PubMedCentral":"10508729","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10508729","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background Abnormalities in incentive decision making, typically assessed using the Iowa Gambling Task (IGT), have been reported in both schizophrenia (SZ) and bipolar disorder (BD). We applied the Expectancy\u2013Valence (E\u2013V) model to determine whether motivational, cognitive and response selection component processes of IGT performance are differentially affected in SZ and BD. Method Performance on the IGT was assessed in 280 individuals comprising 70 remitted patients with SZ, 70 remitted patients with BD and 140 age-, sex- and IQ-matched healthy individuals. Based on the E\u2013V model, we extracted three parameters, 'attention to gains or loses', 'expectancy learning' and 'response consistency', that respectively reflect motivational, cognitive and response selection influences on IGT performance. Results Both patient groups underperformed in the IGT compared to healthy individuals. However, the source of these deficits was diagnosis specific. Associative learning underlying the representation of expectancies was disrupted in SZ whereas BD was associated with increased incentive salience of gains. These findings were not attributable to non-specific effects of sex, IQ, psychopathology or medication. Conclusions Our results point to dissociable processes underlying abnormal incentive decision making in BD and SZ that could potentially be mapped to different neural circuits.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10542273,"openaccessinfo":{"externalids":{"MAG":"2103720839","ACL":null,"DOI":"10.1017\/S0033291712001304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Peridotite xenoliths entrained in magmas near the Alpine fault (New Zealand) provide the first direct evidence of deformation associated with the propagation of the Australian-Pacific plate boundary through the region at ca. 25\u201320 Ma. Two of 11 sampled xenolith localities contain fine-grained (40\u2013150 \u03bcm) rocks, indicating that deformation in the upper mantle was focused in highly sheared zones. To constrain the nature and conditions of deformation, we combine a flow law with a model linking recrystallized fraction to strain. Temperatures calculated from this new approach (625\u2013970 \u00b0C) indicate that the observed deformation occurred at depths of 25\u201350 km. Calculated shear strains were between 1 and 100, which, given known plate offset rates (10\u201320 mm\/yr) and an estimated interval during which deformation likely occurred (<1.8 m.y.), translate to a total shear zone width in the range 0.2\u201332 km. This narrow width and the position of mylonite-bearing localities amid mylonite-free sites suggest that early plate boundary deformation was distributed across at least ~60 km but localized in multiple fault strands. Such upper mantle deformation is best described by relatively rigid, plate-like domains separated by rapidly formed, narrow mylonite zones.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":236290684,"openaccessinfo":{"externalids":{"MAG":"3167302482","ACL":null,"DOI":"10.1130\/G48532.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rats responded on concurrent schedules of shock-postponement or deletion (avoidance) and timeout from avoidance. In Experiment 1, 3 rats' responses on one lever postponed shocks for 20 s and responses on a second lever produced a 1-min timeout according to a variable-interval 45-s schedule. Across conditions, a warning signal (white noise) was presented 19.5 s, 16 s, 12 s, 8 s, or 4 s before an impending shock. Raising the duration of the warning signal increased both avoidance and timeout response rates. Timeout responding, although positively correlated with avoidance responding, was not correlated with the prevailing shock rate. In Experiment 2, 3 rats' responses on one lever deleted scheduled shocks according to a variable-cycle 30-s schedule and responses on a second lever produced a 2-min timeout as described above. After this baseline condition, the avoidance lever was removed and noncontingent shocks were delivered at intervals yoked to the receipt of shocks in the baseline sessions. Timeout responding decreased when the avoidance lever was removed, even though the shock-frequency reduction afforded by the timeout remained constant. These results suggest that a key factor in the reinforcing efficacy of timeout is suspension of the requirement to work to avoid shock, rather than the reduction in shock frequency associated with timeout.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25063192,"openaccessinfo":{"externalids":{"MAG":"1876669986","ACL":null,"DOI":"10.1901\/jeab.2012.98-257","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3494312?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Recent methods based on 3D skeleton data have achieved outstanding performance due to its conciseness, robustness, and view-independent representation. With the development of deep learning, Convolutional Neural Networks (CNN) and Long Short Term Memory (LSTM)-based learning methods have achieved promising performance for action recognition. However, for CNN-based methods, it is inevitable to loss temporal information when a sequence is encoded into images. In order to capture as much spatial-temporal information as possible, LSTM and CNN are adopted to conduct effective recognition with later score fusion. In addition, experimental results show that the score fusion between CNN and LSTM performs better than that between LSTM and LSTM for the same feature. Our method achieved state-of-the-art results on NTU RGB+D datasets for 3D human action analysis. The proposed method achieved 87.40% in terms of accuracy and ranked 1st place in Large Scale 3D Human Activity Analysis Challenge in Depth Videos.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":11828320,"openaccessinfo":{"externalids":{"MAG":"2949782829","ACL":null,"DOI":"10.1109\/ICMEW.2017.8026287","PubMedCentral":null,"ArXiv":"1707.02356"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"English translation \u00a9 2005 M.E. Sharpe, Inc., from the Russian text \u00a9 2003 the authors. \"Model' sem'i v usloviiakh transformatsii rossiiskogo obshchestva,\" Sotsiologicheskie issledovaniia, 2003, no. 7, pp. 92\u2013100. A publication of the Russian Academy of Sciences; the Department of Philosophy, Sociology, Psychology, and Law, RAS; and the Russian Union of Industrialists and Entrepreneurs. Lidiia Valer'evna Kartseva is a doctor of sociological sciences and a professor in the department of sociology, Kazan State University of Power Engineering. Translated by Kim Braithwaite. Marriage and the family as an subject of research in sociology","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219320423,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/10611428.2005.11065186","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In order to improve efficiency when manufacturing gas turbine components, alternative machining techniques need to be explored. In this work, abrasive water jet (AWJ) machining by milling has been investigated as an alternative to traditional milling. Various test campaigns have been conducted to show different aspects of using AWJ milling for the machining of superalloys, such as alloy 718. The test campaigns span from studies of individual AWJ-milled tracks, multi-pass tracks, and the machining of larger components and features with complex geometry. In regard to material removal rates, these studies show that AWJ milling is able to compete with traditional semi\/finish milling but may not reach as high an MRR as rough milling when machining in alloy 718. However, AWJ milling requires post-processing which decreases the total MRR. It has been shown that a strong advantage with AWJ milling is to manufacture difficult geometries such as narrow radii, holes, or sharp transitions with kept material removal rates and low impact on the surface integrity of the cut surface. Additionally, abrasive water jet machining (AWJM) offers a range of machining possibilities as it can alter between cutting through and milling. The surface integrity of the AWJM surface is also advantageous as it introduces compressive residual stress but may require post-processing to meet similar surface roughness levels as traditional milling and to remove unwanted AWJM particles from the machined surface.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1,"unknown":2}},"corpusid":253073354,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/jmmp6050124","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2504-4494\/6\/5\/124\/pdf?version=1666777983","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"When irradiating enzymes with ions, the quasi-elastic damage mechanism becomes dominant at low energies. The incident ions at these energies ( 500 ml). Number of levels fused was similarly associated with EBL (P<0.01) while gender confounded the association between obesity and EBL. Conclusions: Surgeons should anticipate greater blood loss when performing lumbar fusion in obese patients. To reduce operative morbidity, consideration should be given to preoperative weight loss whenever possible.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":58149662,"openaccessinfo":{"externalids":{"MAG":"2606520507","ACL":null,"DOI":"10.1017\/cjn.2015.220","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1017\/cjn.2015.220","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Introduction. Alcoholism is a worldwide health issue, and female consumers are increasing. Prostitution could be linked to alcohol abuse. Objective. To evaluate the effect of self-esteem as an intrapersonal stress factor on alcohol use in female prostitutes. Material and methods. An approved study by the Research Committee. Cross-sectional, analytical study of prostitutes from Cosoleacaque, Veracruz, Mexico. For alcohol use the AUDIT questionnaire was used and for self-esteem, the Coopersmith inventory. Statistical analysis. The Odds Ratio between low self-esteem and alcohol use, 95% confidence intervals and Attributable Fraction in Exposed were calculated. An attempt was made to generate a logistic regression model. Results. The trial sample was made up by 50 prostitutes. The Odds Ratio between low self- esteem and alcohol use was 5.08 (95% CI 0.59 a 43.95), and an Attributable Fraction in Exposed of 80.3%. The logistic model was not built because no variable of the study demonstrated an improvement in the model using the probability ratio test. Conclusions. According to Betty Neuman's system model, low self-esteem has a strong effect and impact in the use and abuse of alcohol","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145281588,"openaccessinfo":{"externalids":{"MAG":"2082055379","ACL":null,"DOI":"10.6018\/EGLOBAL.13.1.157561","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Drying is an important step for the thermochemical conversion of solid fuels, but it is energy-intensive for treating highly moist materials. Methods: To inform the thermal treatment of faecal sludge (FS), this study investigated the drying characteristics and kinetics of various faecal wastes using thermogravimetric analysis and isothermal heating conditions. Results: The findings show that FS from the anaerobic baffled reactor (ABR) and ventilated improved pit latrines (VIP) exhibit similar drying characteristics, with maximum drying rates at 0.04 mg\/min during a constant rate period that is followed by a distinct falling rate period. On the contrary, fresh human faeces (HF) and FS from urine diversion dry toilets (UDDT) exhibited a falling rate period regime with no prior or intermittent constant rate periods. The absence of a constant rate period in these samples suggested limited amounts of unbound water that can be removed by dewatering and vice versa for VIP and ABR faecal sludges. The activation energies and effective moisture diffusivity for the sludges varied from 28 to 36 kJ\/mol and 1.7\u00b710 -7 to 10\u00b710 -7 m 2\/s at 55\u00b0C and sludge thickness of 3mm. The Page model was consistent in modelling the different sludges across all temperatures. Conclusions: These results presented in this study can inform the design and development of innovative drying methods for FS treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221408720,"openaccessinfo":{"externalids":{"MAG":"3037593407","ACL":null,"DOI":"10.12688\/gatesopenres.13137.2","PubMedCentral":"8135097","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.12688\/gatesopenres.13137.2","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The dry reforming of methane over hydroxyapatite-and alumina\/magnesia (commercial Pural MG 30)-supported nickel catalysts was investigated. The catalytic performance of the catalysts prepared with fresh supports highly depended on the basicity, the metal-support interaction, and the metal particle size. Calcination of the supports at 1200 (cid:2) C for 5 h made the catalysts less active because of specific surface area reduction and basicity destruction. However, this treatment allowed avoiding any further catalyst deactivation by thermal sintering and maintained excellent catalytic stability over 300 h of time-on-stream. These tests under simulated industrial conditions (high contact time and long time-on-stream) showed the competitiveness of the prepared catalysts in this important catalytic process.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":213842941,"openaccessinfo":{"externalids":{"MAG":"3002255986","ACL":null,"DOI":"10.1002\/ceat.201900461","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal-mines-albi.archives-ouvertes.fr\/hal-02487485\/file\/A-Comparative-Study-of-Hydroxyapatite-and-Alumina-Based-Catalysts-in-Dry-Reforming-of-Methane.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Computer viruses have many similarities to biological viruses, and their association may offer new perspectives and new opportunities in the effort to tackle and even eradicate them. Evolutionary game theory has been established as a useful tool for modeling viral behaviors. This work attempts to correlate a well-known virus, namely Virlock, with the bacteriophage \u03d56. Furthermore, the paper suggests certain efficient strategies and practical ways that may reduce infection by Virlock and similar such viruses.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":236772067,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/SMAP53521.2021.9610778","PubMedCentral":null,"ArXiv":"2108.00508"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Imbibing reading habits is an essential skill necessary in the acquisition of knowledge, which is highly demanding in the life of every student in the academic environment. However, as modern technological resources keep on advancing, the reading habits of students are also changing with reading on screen. This study examined the reading habits of college sophomore students as affected by technological resources. The survey instruments, distributed to 254 college sophomore students at the Ilocos Sur Polytechnic State College, allowed the respondents to assess their reading habits in terms of reading hours, reading purposes, reading content, and reading attitude, with the technological resources as their tool. The data gathered in the study was analyzed statistically using the simple frequency count and percentage, mean, and Pearson correlation. The findings revealed that the college sophomores achieved an average level in their English subjects. In addition, it was found that the technology resources were moderately adequate to be used for reading among the college sophomores. Despite this, the results still showed that college sophomore students spent 2-3 hours a day reading, primarily in preparation for their exams. In addition, they read the available reading content moderately often, and they perceive a positive attitude towards the use of technological resources for reading. Furthermore, it was revealed that there is a significant relationship between reading habits and academic achievements. The study's findings will be used to improve instructional approaches and to launch e-reading initiatives in colleges.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":247917246,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.24239\/pdg.vol11.iss1.240","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jurnalpaedagogia.com\/index.php\/pdg\/article\/download\/240\/86","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nThoracoscopy is an important option in the treatment of many thoracic pathologies; its use in children, however, is still limited. We have retrospectively evaluated the thoracoscopic activity in our pediatric surgery department in the last six years.\n\n\nMETHODS AND PROCEDURES\nVideo-Assisted Thoracoscopy (VATS) has been routinely adopted in our institutions since 1997. The data of 115 patients who have undergone VATS were reviewed and analysed.\n\n\nRESULTS\nThere were 47 males and 68 females. Mean age at surgery was 66.08 (SD: 58.23) months. Mean body weight at surgery was 21.85 (SD: 16.26) Kg. The patients were divided in four groups according to the pathologies: Patent Ductus Arteriosus (PDA) (n = 95), Pleural Empyema (n = 14), Mediastinal Mass (n = 3) and Lung Disease (n = 3). Complicances were seen in two patients in the PDA group (one laryngeal nerve paralysis and one chylothorax) and one in the pleural empyema group (post-operative bleeding which required blood transfusion).\n\n\nCONCLUSIONS\nVATS can be performed safely and with minimal morbidity. In our experience, early and late complications turned out to be quite low. This survey would support on-going development of thoracoscopy in children.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40694992,"openaccessinfo":{"externalids":{"MAG":"2417684195","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Integer programming is a field of mathematical optimization that has applications across a wide variety of industries and fields including business, government, health care and military. A commonly studied integer program is the knapsack problem, which has applications including project and portfolio selection, production planning, inventory problems, profit maximization applications and machine scheduling. Integer programs are computationally difficult and currently require exponential effort to solve. Adding cutting planes is a way of reducing the solving time of integer programs. These cutting planes eliminate linear relaxation space. The theoretically strongest cutting planes are facet defining inequalities. This thesis introduces a new class of cutting planes called multiple variable merging cover inequalities (MVMCI). The thesis presents the multiple variable merging cover algorithm (MVMCA), which runs in linear time and produces a valid MVMCI. Under certain conditions, an MVMCI can be shown to be a facet defining inequality. An example demonstrates these advancements and is used to prove that MVMCIs could not be identified by any existing techniques. A small computational study compares the computational impact of including MVMCIs. The study shows that finding an MVMCI is extremely fast, less than .01 seconds. Furthermore, including an MVMCI improved the solution time required by CPLEX, a commercial integer programming solver, by 6.3% on average.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":123904809,"openaccessinfo":{"externalids":{"MAG":"2301631805","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the immediate aftermath of World War II, the roman fleuve underwent an unexpected revival in Britain, reaching a new peak of popularity in the work of Anthony Powell, C. P. Snow, Lawrence Durrell, and Doris Lessing (among others). Its success raises the question of the relationship between the novel and history in a peculiarly sharp form, a point emphasized by Perry Anderson during a 1983 conference commemorating the centenary of Marx's death when he described Powell's avowedly anti-Marxist series A Dance to the Music of Time as \"the most important piece of postwar fiction in the English language for the metropolitan world.\" Anderson's judgment, based on the claim that a masterpiece can be identified in terms of its historical coordinates, ignores the extent to which the postwar roman fleuve incorporated secret histories, occult ironies, irrational or pathological episodes, and coincidental indeterminacies as part of a fascination with unorthodox causal structures and the breakup of secular time. Today these contingent textual incidents seem to foreshadow a wider set of uncertainties regarding the true scope of historical narrative: the place of the event in cultural analysis, the interruption of \"homogeneous, empty time,\" the attempt to introduce a poetics of history, and the interrogation of secular models of explanation. Since these questions also intrude upon the world of fiction, we might ask: to what extent does the novel now depend upon the critique of historicism?","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":162301469,"openaccessinfo":{"externalids":{"MAG":"2083513916","ACL":null,"DOI":"10.1215\/00295132-2009-036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The purpose of this study was to investigate the correlation between food behavior and Attention Deficit Hyperactivity Disorder (ADHD) score in elementary students in Suwon-si, Gyeonggi-do. Two hundreds and thirty two students (113 male and 119 female) in grades 4\u223c6 participated. We assessed food behavior by us-ing Nutrition Quotient (NQ). NQ was examined by an NQ questionnaire, which consisted of 19 food behavior checklist items. Their items were grouped into five categories: balance, diversity, moderation, regularity, and practice. All data were statistically analyzed by SPSS 18.0. Among the five factors, NQ for food behavior and balance factor showed the lowest score, whereas that of diversity factor showed the highest score. The final Nutrition Quotient (NQ) score weighted on such five factors was 62.59 points. The average level of ADHD by Conners-Wells Adolescent Self-Report Scale (Short Form) [CASS(S)] was 17.02 points out of a to-tal of 81 points. Six students (2.2%) who scored more than 41 points were classified as ADHD risk. By gen-der, male students (19.76 points) showed a higher CASS(S) score than female students (14.41 points) did. There was a significant negative correlation between NQ and CASS(S) score (r=\u22120.445, P<0.001). Multiple regression determined the effects of moderation (Exp(\u03b2)=\u22120.193, P<0.01) and practice (Exp(\u03b2)=\u22120.345, P<0.001) on CASS(S) score. In conclusion, distinctive nutritional education is needed for students with a high level of ADHD to help their understanding considering their different levels of attention.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":147618775,"openaccessinfo":{"externalids":{"MAG":"2280916259","ACL":null,"DOI":"10.14373\/JKDA.2015.21.2.110","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nCachexia, defined as a loss of adipose tissue and skeletal muscle mass not reversible by nutritional support, is present in the majority of patients with advanced cancer progression. This reduces the patient's quality of life and impacts their ability to function normally and undergo treatments. Reversing cachexia has been problematic due to a lack of quality pre-clinical models. Traditional xenograft models using cell lines are limited due to their inability to accurately replicate the whole body response to cancer. Champions Oncology overcomes this challenge through the use of its innovative Champions TumorGraft\u2122 platform, where primary human tumors are implanted into immunocompromised mice in a manner that preserves the biological properties of the original human tumor. Champions has identified a panel of three TumorGraft models which spontaneously induce cachexia when implanted subcutaneously into nude mice: 1) CTG-0282, a pancreatic cancer model, 2) CTG-0765, a NSCLC model, and 3) CTG-0804, a renal cell carcinoma model. All three models have shown a greater than 90% cachexia rate, as demonstrated by lost body weight, over multiple passages. In addition, loss of body weight correlates with an increase in tumor volume size. Mice that have little or no tumor growth show no loss of body weight. Past studies have indicated a function for pro-inflammatory cytokines, including tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin 1 (IL-1), interleukin 6 (IL-6) and interferon gamma (IFN\u03b3), in the cachexia process. Champions is currently investigating the roles of these possible tumor-mediated factors in the aforementioned models. Principle among these factors is IL-6, which has been shown to be required in the regulation of cachexia in tumor-bearing mice and is correlated with weight loss and survival in patients. Preliminary results from our studies suggest a correlation between IL-6 levels and spontaneous cachexia in Champions TumorGraft models. In summary, we demonstrate that the Champions TumorGraft platform preserves the biological properties of the original human tumor, including spontaneous cachexia behavior in these models, and is therefore ideal for oncology drug development programs focused on the inhibition of cachexia.\n\nCitation Format: Nathan Anderson, Tin Oo Khor, Andrew Feldhaus, Katie Olson, John Latham, David Sidransky, Elizabeth M. Bruckheimer. Characterization of spontaneous in vivo cachexia models in Champions TumorGraft\u2122 models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2792. doi:10.1158\/1538-7445.AM2013-2792","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":71810083,"openaccessinfo":{"externalids":{"MAG":"2013573043","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-2792","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"When Tim Berners-Lee published the roadmap for the semantic web in 1998, it was a promising glimpse into what could be accomplished with a standardized metadata system, but nearly 20 years later, adoption of the semantic web has been less than stellar. In those years, web technology has changed drastically, and techniques for implementing semantic web compliant sites have become relatively inaccessible. This poster outlines a JavaScript framework called Beltline.js which seeks to encourage the use of metadata by making it easy to integrate into modern web best-practices.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70030339,"openaccessinfo":{"externalids":{"MAG":"2900350389","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Climate-induced disasters are and will continue to be on the rise, and thus search-and-rescue (SAR) operations, where the task is to localize and assist one or several people who are missing, become increasingly relevant. In many cases the rough location may be known and a UAV can be deployed to explore a given, confined area to precisely localize the missing people. Due to time and battery constraints it is often critical that localization is performed as efficiently as possible. In this work we approach this type of problem by abstracting it as an aerial view goal localization task in a framework that emulates a SAR-like setup without requiring access to actual UAVs. In this framework, an agent operates on top of an aerial image (proxy for a search area) and is tasked with localizing a goal that is described in terms of visual cues. To further mimic the situation on an actual UAV, the agent is not able to observe the search area in its entirety, not even at low resolution, and thus it has to operate solely based on partial glimpses when navigating towards the goal. To tackle this task, we propose AiRLoc, a reinforcement learning (RL)-based model that decouples exploration (searching for distant goals) and exploitation (localizing nearby goals). Extensive evaluations show that AiRLoc outperforms heuristic search methods as well as alternative learnable approaches, and that it generalizes across datasets, e.g. to disaster-hit areas without seeing a single disaster scenario during training. We also conduct a proof-of-concept study which indicates that the learnable methods outperform humans on average. Code and models have been made publicly available at https:\/\/github.com\/aleksispi\/airloc.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":257426964,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3384\/ecp199003","PubMedCentral":null,"ArXiv":"2209.03694"},"license":"CCBY","url":"https:\/\/ecp.ep.liu.se\/index.php\/sais\/article\/download\/715\/621","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A methodic pathway is suggested for the definition, elaboration, evaluation and introduction of farming systems based on an \"integrated' or an \"ecosystem-oriented' vision, both considered more sustainable than a \"world-market-oriented' vision. The objectives of these three basic types of systems are defined in measurable terms with respect to the major social values or interests supported or adversely influenced by agriculture. A strategy is assessed through which the objectives can be achieved while avoiding their conflicts. Arable farming is taken as an example of the elaboration, evaluation and introduction of integrated and ecosystem-oriented systems. It is discussed how prototype systems can be developed on an experimental farm, evaluated by a pilot group of farmers and dispersed on a large scale. For the short term it is recommended to focus research and policy on integrated farming systems. For the long term it is recommended to develop ecosystem-oriented farming systems to solve the agricultural crisis in a more comprehensive and sustainable way","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":82376036,"openaccessinfo":{"externalids":{"MAG":"1597070401","ACL":null,"DOI":"10.18174\/njas.v40i3.16507","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.18174\/njas.v40i3.16507","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Type 4 fimbriae of Pseudomonas aeruginosa are surface filaments involved in host colonization. They mediate both attachment to host epithelial cells and flagella\u2010independent twitching motility. Four additional genes, pilW, pilX, pilY1 and pilY2, are located on Spel fragment E in the 5 kb intergenic region between the previously characterized genes pilV and pilE, which encode prepilin\u2010like proteins involved in type 4 fimbrial biogenesis. The phenotypes of a transposon insertion and other mutations constructed by allelic exchange show that these genes are involved in the assembly of type 4 fimbriae. The PilW and PilX proteins are membrane located, possess the hydrophobic N\u2010terminus characteristic of prepilin\u2010like proteins, and appear to belong to the GspJ and GspK group of proteins that are required for protein secretion in a wide range of Gram\u2010negative bacteria. These findings increase the similarities between the fimbrial biogenesis and the Gsp\u2010based protein\u2010secretion super\u2010systems. PilY1 is a large protein with C\u2010terminal homology to the PilC2 protein of Neisseria gonorrhoeae, thought to be a fimbrial tip\u2010associated adhesin, and which, like PilY1, is involved in fimbrial assembly. PilY1 appears to be located in both the membrane and the external fimbrial fractions. PilY2 is a small protein that appears to play a subtle role In fimbrial biogenesis and represents a new class of protein.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1138291,"openaccessinfo":{"externalids":{"MAG":"2082730687","ACL":null,"DOI":"10.1111\/j.1365-2958.1996.tb02665.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper starts with a \"primer\" on what we know about the conceptual and empirical links between development and urbanization. While historical experience of developed countries is reviewed, today's rapid urbanization in developing countries offers an intense set of challenges. Rapid urbanization requires massive population movements and enormous local and inter-city infrastructure investments in a modern context of heavy government interventions in economies. This context raises under-researched issues, discussed in the second part of the paper. First concerns the spatial form of development. How much development should be focused in mega-cities, or huge urban clusters, as opposed to being more spatially dispersed, a critical question facing China and India today? How do we conceptualize and measure both the benefits and costs of increased urban concentration; and how are they linked to a country's evolving national industrial composition? Second, what is the evolution of spatial income inequality under massive rural-urban migration? Is inequality heightened today relative to the past by national government policies which \"favor\" certain cities and regions and by local government policies in those cities that may try to deflect migrants by offering them poor living conditions?","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":31838347,"openaccessinfo":{"externalids":{"MAG":"2072852193","ACL":null,"DOI":"10.1111\/j.1467-9787.2009.00636.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc4255706?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Extracting and compiling certified programs may introduce bugs in otherwise proven-correct code, reducing the extent of the guarantees that proof assistants and correct-byconstruction program-derivation frameworks provide. We present a novel approach to the extraction and compilation of embedded domain-specific languages developed in a proof assistant (Coq), showing how it allows us to extend correctness guarantees all the way to a verification-aware assembly language. Our core idea is to phrase compilation of shallowly embedded programs to a lower-level deeply embedded language as a synthesis problem, solved using simple proof-search techniques. This technique is extensible (support for individual language constructs is provided by a user-extensible database of compilation tactics and lemmas) and allows the source programs to depend on axiomatically specified methods on externally implemented data structures, delaying linking to the assembly stage. We do proof-generating static analysis of object lifetimes to avoid the need for a garbage collector, so that our output code is suitable for embedded systems or system infrastructure. We have composed our new transformation with others in Coq to provide the first fully proofgenerating automatic translation from SQL-style relational programs into executable assembly code.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":43130325,"openaccessinfo":{"externalids":{"MAG":"2528503660","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A five day old female baby was admitted with distension of abdomen since birth and nonbilious vomiting, fever of one day duration. Blood culture grew Klebsiella pneumoniae. Abdominal exploration revealed thick walled cavity containing purulent fluid grew klebsiella pneumoniae which was sensitive to various antibiotics including gentamycin. The child was treated with injection gentamycin and ceftazidime. The child had uneventful recovery and is doing well 3 years post operatively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26902956,"openaccessinfo":{"externalids":{"MAG":"2409254230","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract 689 Background: Lenalidomide was demonstrated to have significant single agent activity in relapsed aggressive B cell lymphoma (J Clin Oncol. 2008;26:4952\u20137, Ann Oncol. 2011;22:1622\u20137). In a phase I study, we previously demonstrated that Lenalidomide 25 mg day 1\u201310 of the cycle can be combined with RCHOP21 and this combination does not result in dose delays or increased toxicity (Leukemia 2011;12:1877\u201381). We now present phase 2 results of R2CHOP in treatment of patients with aggressive B-cell lymphoma. Methods: Eligible patients were adults with newly diagnosed CD20 positive diffuse large B cell (DLBCL) or grade 3 follicular lymphoma (FL). The response was evaluated using PET\/CT by standard criteria (J Clin Oncol. 2007;25:579\u2013586). The progression free survival (PFS) was defined as time from diagnosis to disease progression or death. Results: 51 patients - 6 enrolled at the MTD in phase 1 portion of the study and 45 in phase 2 portion were included in the analysis. The median age was 65 years (range, 19\u201387). 35% of patients were 70 and older. 63% (32\/51) were males. 47 patients (92%) had DLBCL and 4 (8%) patients had FL grade 3. The international prognostic index (IPI) was low, low-intermediate, high-intermediate and high in 8 (15%), 18 (35%), 18 (35%) and 7 (14%) patients respectively. 31 patients (60%) had stage 4 disease. Hematological toxicities were: grade 3 and 4 thrombocytopenia (20% and 20% of patients respectively); grade 3 and 4 neutropenia (18% and 71% of patients respectively). Overall 27% of patients experienced a grade 3 or higher non-hematological toxicity at least possibly related to treatment. The most frequent were febrile neutropenia (10%), nausea (4%), urinary tract infection (4%), vascular access complication (4%), and dehydration (4%). 1 patient (2%) developed thrombosis. There was one death (2%) secondary to bowel perforation\/sepsis. For 47 patients evaluable for response, the overall response (ORR) and complete response (CR) rates were 98% and 83% respectively. The PFS was 73% at 12 months (Figure). Since the enrolled patients represented a relatively high-risk group (49% intermediate high or high IPI, significant proportion of elderly male patients), the PFS in R2CHOP was compared to PFS in a contemporary cohort of 87 consecutive patients with DLBCL participating in Mayo Clinic Lymphoma Database and treated with standard RCHOP alone. The PFS was 62% at 12 months in this cohort and was inferior to R2CHOP (Figure). Conclusion: Lenalidomide combined with standard R-CHOP21 chemotherapy (R2CHOP) demonstrates predictable safety profile. The ORR and CR rates and PFS are encouraging in elderly high IPI patients, and compared favorably to the R-CHOP treated historical cohort with similar clinical characteristics. A randomized trial will be needed to confirm the benefits of this novel combination. Disclosures: Off Label Use: lenalidomide in treatment of NHL. Reeder:Celgene: Research Funding. Ansell:Seattle Genetics, Inc.: Research Funding; Celgene Corporation: Consultancy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":78983813,"openaccessinfo":{"externalids":{"MAG":"2584782292","ACL":null,"DOI":"10.1182\/BLOOD.V120.21.689.689","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is of paramount importance for executives to be well aware of registered nurse (RN) hidden replacement costs related to musculoskeletal injuries. Developing and implementing an ergonomic plan that includes procurement of appropriate lifting equipment at the point of care makes sense. Armed with an ergonomic plan, proactive case management, and a return to work program, the organization is positioned for fiscal success. The ANA's Handle With Care campaign addressed the fact that 12% of RN turnover and 38% of RN workers' compensation pay are related to back strains. Using the benchmarks reported in the Handle With Care campaign, the average cost of replacing an RN who leaves nursing due to a back injury ranged from $25,450 to $38,280 per nurse. Health care worker injury prevention should be valued as a retention strategy, as well as a fiscal responsibility where all stakeholders benefit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26869994,"openaccessinfo":{"externalids":{"MAG":"195055120","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Glioblastoma multiforme (GBM) accounts for the most aggressive form of tumor showing poor prognosis. Prevailing treatment modality includes chemotherapy with temozolomide (TMZ) concomitant with surgical resection and\/or irradiation. However, it has been observed that a number of patients are developing resistance to TMZ owing to its high dosage regimen. The aim of this study is to examine the effects of diosgenin (DSG), a natural steroidal saponin obtained from fenugreek, in combination with TMZ in human GBM cells and TMZ resistant GBM cells. Methodology: The potential of combinatorial chemotherapy for overcoming TMZ resistance was evaluated through development of TMZ resistant GBM clones. These clones were generated by treatment of GBM cells with sub-lethal dose of TMZ over several cycles. Cellular effects were studied by viability assay, flow cytometry and wound healing assay on both single and combined drug treated GBM cells and TMZ resistant cells, respectively. The morphological study and cellular uptake in combined or individual drug treated cells was assessed by microscopy and immunofluorescence staining. The time dependant effect of drugs on invasive and migratory potential of GBM cells and TMZ resistant cells was analysed through zymography for matrix metalloproteinases (MMPs) activity and western blot for apoptotic proteins, epithelial and mesenchymal (EMT) markers, MMPs and VEGF expression. Further, the drug induced apoptosis was also assessed through chromatin condensation and DNA laddering assay. Results: Our investigation shows that co-administration of DSG and TMZ resulted in a substantial increase in GBM cell apoptosis and marked inhibition of cell growth in vitro. Anti-angiogenic and anti-invasive potential of DSG and TMZ were assessed through in vitro studies. At molecular level, DSG and TMZ synergistically lower XIAP expression and cleavage of intracellular death substrates such as PARP thereby shifting the balance from survival to apoptosis as indicated by the rise in the sub-G1 cell population. This combination also alters EMT markers, downregulates the expression of Bcl-xL, Bcl-2, Mcl1, MMPs and VEGF and induces expression of Bax, AIF, cytochrome C. Conclusion: The results suggested that DSG in combination with TMZ reduced the dose of TMZ, when administered singly, and also inhibited the migration and invasion of GBM and TMZ resistant cells. It induced apoptosis and altered the expression of EMT markers. These findings reveal a new therapeutic potential for overcoming TMZ resistance in GBM therapy. This novel modality may be a promising tool for GBM treatment. Citation Format: Y Rajesh, Angana Biswas, Subhayan Das, Mahitosh Mandal. Diosgenin and temozolamide: A potential combinatorial chemotherapy to overcome temozolamide resistance in glioblastoma multiforme [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4105. doi:10.1158\/1538-7445.AM2017-4105","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":79524444,"openaccessinfo":{"externalids":{"MAG":"2741835165","ACL":null,"DOI":"10.1158\/1538-7445.AM2017-4105","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Here we present a review of the history of modern understanding of the strength of the Atlantic Meridional Overturning Circulation (MOC), which arguably originates in 1957. This was the year that the Discovery cruises not only observed the Atlantic deep western boundary current for the first time, but also completed a transatlantic section along 24oN, from which reliable estimates of the size and structure of the MOC were later obtained. It was also the year Stommel began to publish his estimates of the size of the Atlantic overturning. These key developments are put into the context of early qualitative pictures of the Atlantic MOC which can be traced back to 1798. The early proposals differed significantly from Wust's qualitative picture of layered interhemispheric exchange, published in 1935 but still broadly accepted today, and on which subsequent quantification relied. Early estimates of the Atlantic MOC strength, as by-products of regional circulation schemes, were by today's standard weak at 6-8 Sv. Stommel's work from 1957 and later developments in the 1980's produced much stronger overturning. Recognition of the importance of the MOC's role in meridional heat transport, necessitating studies dedicated to its quantification, led to a consensus regarding its strength in the early 1980's. The accepted 16-18 Sv MOC resulting from the 1957 Discovery section analysis supported Stommel's 1957 work and has since been verified by independent observations. We examine only the steady state MOC here, understanding and quantification of its variability are still very much evolving.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129321780,"openaccessinfo":{"externalids":{"MAG":"1508886499","ACL":null,"DOI":"10.1029\/173GM03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Brazilian water legislation advocates that some uses have priority over others, but this aspect has never been clearly addressed, generating conflicts. Water authorities usually refer to hydrological models to justify their decisions on water allocation. However, a significant group of stakeholders does not feel qualified to discuss these models and is excluded from the decision process. We hereby propose a hydrologically robust method to correlate water uses with their respective reservoir alert volumes, which should empower the less formally educated stakeholders. The method consists of: (i) generating the water yield versus reliability curve, using a stochastic approach; (ii) generating the yield versus alert volume family of curves, using a water-balance approach; (iii) calibrating the key parameter T (depletion duration) using field data; and (iv) associating each water use with its alert volume. We have applied the method to four of the largest reservoirs (2 \u00d7 103\u20132 \u00d7 102 hm3) in the semi-arid Cear\u00e1 State. The results indicate that low-priority water uses should be rationalized when the reservoir volume is below 20%, whereas uses with very high priority should start rationalization when it is below 11%. These hydrological guidelines should help enhance water governance among non-specialist stakeholders in water-scarce and reservoir-dependent regions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":134496394,"openaccessinfo":{"externalids":{"MAG":"2900468748","ACL":null,"DOI":"10.3390\/W10111628","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a detailed study of a combined actively and passively Q-switched (CAPQ) laser with an acousto-optic modulator (AOM) and a codoped Cr4+, Nd3+: YAG crystal. The hybrid Q-switch approach is used to produce a short laser pulse with stable and tunable repetition rates. The timing jitter, average pulse width, and average pulse amplitude vary periodically with the AOM modulation frequency under a fixed pump power. The repetition rate of the CAPQ laser can be turned approximately from 4 kHz to 16 kHz with the jitter less than 400 ns.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120522109,"openaccessinfo":{"externalids":{"MAG":"2016420545","ACL":null,"DOI":"10.1088\/0256-307X\/23\/7\/040","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The contradiction between the stated preferences of social media users toward privacy and actual privacy behaviors has suggested a willingness to trade privacy regulation for social goals. This study employs data from a survey of 361 social media users, which collected data on privacy attitudes, online privacy strategies and behaviors, and the uses and gratifications that social media experiences bring. Using canonical correlation, it examines in detail how underlying dimensions of privacy concern relate to specific contexts of social media use, and how these contexts relate to various domains of privacy-protecting behaviors. In addition, this research identifies how specific areas of privacy concern relate to levels of privacy regulation, offering new insight into the privacy paradox. In doing so, this study lends greater nuance to how the dynamic of privacy and sociality is understood and enacted by users, and how privacy management and the motivations underlying media use intersect.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":45875801,"openaccessinfo":{"externalids":{"MAG":"2291207401","ACL":null,"DOI":"10.1080\/08838151.2015.1127245","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/figshare.com\/articles\/journal_contribution\/Why_We_Share_A_Uses_and_Gratifications_Approach_to_Privacy_Regulation_in_Social_Media_Use\/10766159\/1\/files\/19278578.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"CN02-03 For many years the clinical advances for patients with myeloma were limited. The recent approval of the proteasome inhibitor bortezomib and immunomodulatory agent lenalidomide has revolutionized patient care and outcomes for patients at all phases of their disease. Preclinical investigations have led to clinical trials that seek to optimally combine emerging agents with approved agents, as well as to define which new agents are best suited for Phase I\/II trials in myeloma. Targets such as HSP-90, HDACs, monoclonal antibodies, CDK inhibitors, and many others were interrogated in preclinical models, and have now yielded clinical benefit for patients with relapsed or refractory myeloma. Further preclinical evaluation is critical to designing rational clinical trials and to developing appropriate correlative studies for these innovative clinical trials.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":79837480,"openaccessinfo":{"externalids":{"MAG":"2744415914","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: To study the association between axial length (AL) and the thickness of the lens, retina, choroid, and cone density with swept-source optical coherence tomography (SS-OCT) and an adaptive optics (AO) fundus camera. Design: A prospective cross-sectional study. Methods: This study included 136 eyes in 68 subjects. SS-OCT was used to quantify the thickness of the lens, ganglion cell complex (GCC) layer, inner nuclear layer (INL), outer retinal layer (ORL), and choroid layer. Adaptive optics was used to quantify spatial features of the cone photoreceptors, including density, spacing, regularity, and dispersion. The associations among the AL and the thickness of lens, retina, choroid, and cone features were evaluated with linear regression. Results: With the severity of myopia, the increased AL was associated with thinning of the lens (P < 0.001, 95% CI: \u2212100.42 to \u221249.76). The thickness of the ORL and choroid decreased significantly (all P < 0.001), whereas the thickness of the GCC and INL decreased only in the outer ring (both P < 0.01). There was a significant correlation between the cone density\/spacing and AL (both P < 0.001). Although cone density was reduced from 25,160\/mm2 to 19,134\/mm2 in the inner region and from 17,458\/mm2 to 13,896\/mm2 in the outer region, the best-corrected visual acuity (BCVA) was 20\/20 or greater. Conclusions: We found that the lens thickness (LT), ORL, and cone density decreased in myopia. While decreasing cone density and ORL thickness should be related to axial elongation, decreasing of LT might imply intrinsic physical accommodation. These results provide further morphological changes of myopia.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245221983,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fmed.2021.796778","PubMedCentral":"8716878","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3389\/fmed.2021.796778","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Mutual information is commonly used in speech processing in the context of statistical mapping. Examples are the optimization of speech or speaker recognition algorithms, the computation of performance bounds on such algorithms, and bandwidth extension of narrow-band speech signals. It is generally ignored that speech-signal derived data usually have an intrinsic dimensionality that is lower than the dimensionality of the observation vectors (the dimensionality of the embedding space). In this paper, we show that such reduced dimensionality can affect the accuracy of the mutual information estimate significantly. We introduce a new method that removes the effects of singular probability density functions. The method does not require prior knowledge of the intrinsic dimensionality of the data. It is shown that the method is appropriate for speech-derived data.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":34648089,"openaccessinfo":{"externalids":{"MAG":"1547317253","ACL":null,"DOI":"10.21437\/Interspeech.2007-235","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper examines the information embedded in both the stock and option markets prior to takeover announcements. During normal periods, buyer-seller initiated stock volume imbalances are significant predictors of next-day stock returns and option volume imbalances are uninformative. However, prior to takeover announcements, call volume imbalances are strongly positively related to next-day stock returns. Cross-sectional analysis shows that those takeover targets with the largest pre-announcement call-imbalance increases experience the highest announcement-day returns. The largest increase in buyer-initiated trading activity is in short-term out-of-the-money calls that subsequently experience the largest returns. Collectively, these findings are consistent with the hypothesis that, in the presence of pending extreme informational events, the options market plays an important role in price discovery.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":18730698,"openaccessinfo":{"externalids":{"MAG":"2078301694","ACL":null,"DOI":"10.1086\/429654","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The spatial structure of natural populations is key to many of their evolutionary processes. Formal theories analysing the interplay between natural selection and spatial structure have mostly focused on populations divided into distinct, non-overlapping groups. Most populations, however, are not structured in this way, but rather (self-)organise into dynamic patterns unfolding at various spatial scales. Here, we present a mathematical framework that quantifies how patterns and processes at different spatial scales contribute to natural selection in such populations. To that end, we define the Local Selection Differential (LSD): a measure of the selection acting on a trait within a given local environment. Based on the LSD, natural selection in a population can be decomposed into two parts: the contribution of local selection, acting within local environments, and the contribution of interlocal selection, acting among them. Varying the size of the local environments subsequently allows one to measure the contribution of each length scale. To illustrate the use of this new multiscale selection framework, we apply it to two simulation models of the evolution of traits known to be affected by spatial population structure: altruism and pathogen transmissibility. In both models, the spatial decomposition of selection reveals that local and interlocal selection can have opposite signs, thus providing a mathematically rigorous underpinning to intuitive explanations of how processes at different spatial scales may compete. It furthermore identifies which length scales\u2014and hence which patterns\u2014are relevant for natural selection. The multiscale selection framework can thus be used to address complex questions on evolution in spatially structured populations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245439777,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2021.12.21.473617","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1101\/2021.12.21.473617","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In the frame of the ANR program GAARanti, aiming to track regional emersion surfaces and potential timing of land emersion or drowning, we conducted new field studies in islands belonging to the Anguilla Bank (Saint Barthelemy, Saint Martin, Tintamarre and Anguilla), the northernmost bank located in the forearc of the Lesser Antilles subduction zone and south of the Anegada passage. Our new micropaleontological, sedimentological and paleoenvironmental investigations allow a highly accurate calibration of the Neogene successions using large benthic foraminifers, planktonic foraminifers and calcareous nannofossils. We determine three main regional unconformities cropping out on the islands of the Anguilla bank. \nInterpretations of seismic lines acquired during the AntiTheSis (2016) and GARANTI (2017) cruises allow to reconstruct the tectono-sedimentary evolution of the offshore forearc basins, between South Saba Bank and Sombrero Basin. We use our well constrained onshore dataset and petroleum industry wells drilled in the Saba Bank to propose a constrained sismostratigraphy of offshore basins and onshore-offshore correlations. \nAt regional scale, we identify three main unconformities dated: (1) Late Eocene, (2) Mid Miocene (ca 15 Ma) and (3) Zanclean (4 Ma). \nThe Late Eocene unconformity is related to compressional tectonics and led to the emergence of most of our study area. Then subsidence occurred and topographic depressions were infilled by Oligocene to Early Miocene deposits, partly controlled by extensional fault activity along NW-SE and ENE-WSW faults systems bounding the Kalinago Basin and Anguilla Bank, respectively. The Mid Miocene unconformity is related to tectonics with increasing importance from south to north, thus probably related to the onset of the opening of Anegada Passage. This unconformity is related to emergence and erosion on the Anguilla and Saba Banks. The northern Antilles then subsided and most of basins reveal passive infilling during Middle Miocene to Pliocene. The Zanclean unconformity is related to localized uplifts that led to the final emergence of Anguilla, Tintamarre and St Martin carbonate platforms.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":216851373,"openaccessinfo":{"externalids":{"MAG":"2998024302","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A newborn girl with multiple anomalies had an interstitial deletion of the long arm of chromosome 7 (46, XX,der(7)mat). The patient's mother and maternal grandmother were carriers of a balanced translocation, 46,XX, inv ins(5;7)(q14;q3200q2200). Both cytogenetic and clinical findings were similar to those in the two cases already described.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21494208,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The founding fathers of the Commonwealth of Independent States have declared that the states have no territorial claims upon one another. Were this only so!","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144102326,"openaccessinfo":{"externalids":{"MAG":"1975399635","ACL":null,"DOI":"10.2753\/RSS1061-1428340144","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although the peptidoglycan cell wall is an essential structural and morphological feature of most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently dispensable under standard culture conditions. By modulating a single growth parameter\u2014extracellular pH\u2014we discovered a subset of these so-called 'redundant' enzymes in Escherichia coli are required for maximal fitness across pH environments. Among these pH specialists are the class A penicillin binding proteins PBP1a and PBP1b; defects in these enzymes attenuate growth in alkaline and acidic conditions, respectively. Genetic, biochemical, and cytological studies demonstrate that synthase activity is required for cell wall integrity across a wide pH range and influences pH-dependent changes in resistance to cell wall active antibiotics. Altogether, our findings reveal previously thought to be redundant enzymes are instead specialized for distinct environmental niches. This specialization may ensure robust growth and cell wall integrity in a wide range of conditions. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261353971,"openaccessinfo":{"externalids":{"MAG":"2939226595","ACL":null,"DOI":"10.7554\/eLife.40754","PubMedCentral":"6456298","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In India about 75 percent of the cultivated area is rainfed and since about 42 per cent of- our food comes from such areas, there is considerable variation in food production depending upon the amount and distribution of rainfall Semi-arid areas where the annual potential evapotranspiration exceeds-the mean\u2014annual rainfall exist in several of our States. In such areas crop fortune depends very much on vagaries of weather: The annual rainfall in these areas is usually less than 75 cm and there occurs sometimes prolonged dry spells within the rainy season. It is then the distribution of rainfall during a season more important than its amount. While the rainfall, coupled with the moisture storage property of soils-ensurethe--moisture supply, the Water loss taking place in the form of evapotranspiration, runoff and deep drainage places an evapotranspirative demand during the growing season. It is, therefore, the- progressive balance. between the receipt and expenditure of the moisture in the soil which creates favourable or unfavourable conditions for successful crop production. One can, thus, with the help of rainfall distribution and potential evapotranspiration values determine conditions for drought for a specific period in relation to a given variety of crop in the region. \n\u00a0 \nSeveral research workers have attempted to study the various aspects of drought on this basis. Their studies mostly relate to occurrence of dry spells, water availability periods, drought mapping, Palmer indexing and spectrum analysis for assessing and forecasting of drought. These studies have not taken into account the crop yields in determining the agricultural drought. \n\u00a0 \nIn the present paper, therefore, data on rainfall and yield of a crop like jowar have been analysed for certain, semi-arid areas of western India for characterising the agricultural drought and its intensity. The recurrence of drought in relation of jowar has also been studied.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":130117054,"openaccessinfo":{"externalids":{"MAG":"2261085647","ACL":null,"DOI":"10.54302\/mausam.v35i3.2220","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/mausamjournal.imd.gov.in\/index.php\/MAUSAM\/article\/download\/2220\/2034","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Six years old seedlings of Picea mongolica were planted in pots with horizontal and vertical root treatments. Soil samples were stratified collected, and their available nitrogen (N), phosphorus (P), and potassium (K) contents were determined. The results showed that the available contents of N, P and K in soils along the distance from Picea mongolica seedlings root surface had a special gradient distribution. Near root surface, there was a depletion zone of soil available N, P, and K, and along the distance from it, the nutrient element contents increased gradually and reached their background values in the bulk soil. In the horizontal root treatment, the depletion zone of soil available N, P, and K existed in different distance from root surface, owing to the absorption and the use intensity of the seedlings to these nutrient elements. The depletion zone of soil available N and K appeared from 1 cm from root surface, and that of available P existed in 0.5 cm from root surface. In the vertical root treatment the depletion zone of available N and K also appeared from 1 cm from root surface as in the horizontal root treatment, but the available P content near root surface was lower than that far away from root surface. It is proved that the absorption and the utilize intensity of soil available P by Picea mongolica seedlings was intense, which might become a limiting factor to its growth and development. Therefore, Picea mongolica should be planted on soils rich in phosphorus, or P and N fertilizers should be applied to improve the absorption and the use efficiency of available P by Picea mongolica.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34695931,"openaccessinfo":{"externalids":{"MAG":"2361185201","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of this study was to investigate whether home monitoring of blood glucose of diabetic dogs by owners would be possible on a long-term basis. The owners of 12 diabetic dogs were each asked to generate four glucose curves by taking capillary blood samples from their dog's ear, at three- to four-week intervals. Within one week of each curve being produced by the owner, an additional curve was produced by a veterinarian in the hospital. Ten owners were able to generate blood glucose curves; three of them needed a second demonstration, and two telephoned for further guidance. The blood glucose concentrations obtained from the first two 'hospital' curves were significantly lower than those measured at home. Overall, in 42 per cent of cases, the treatment based on the hospital curves would have been different from that based on 'home' curves. The results of this study indicate that the majority of owners were able and willing to perform long-term monitoring of the blood glucose concentrations of their dogs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42815795,"openaccessinfo":{"externalids":{"MAG":"2072577269","ACL":null,"DOI":"10.1111\/J.1748-5827.2003.TB00158.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Medical device associated thrombosis is an important clinical problem. This type of thrombosis can result from Factor XII (FXII) binding to non-natural surface materials and subsequent activation of the contact pathway. This drives the development of new therapeutic strategies to block this pathway and information on the structural properties of FXII should catalyse this quest. Presently, there is no publicly available crystal structure of full-length FXII. However, the AlphaFold Protein Structure Database provides a model structure. We here explore this model in combination with previous structure-function studies to identify opportunities for selective pharmacological blockade of the contribution of FXII in medical device associated thrombosis. Previous studies demonstrated that FXII activation is dependent on molecular cleavage after R353. We subsequently proposed that protein conformation protects this cleavage site to ensure zymogen quiescence and prevent inappropriate FXII activation. The AlphaFold model shows that a small loop containing R353 indeed is buried in the globular molecule. This is the result of intra-molecular interactions between the (N-terminal) Fibronectin type II domain, (central) kringle and (C-terminal) protease domain, in a structure that resembles a three-point harness. Furthermore, this interaction pushes the intermediate domains, as well as the flexible proline-rich region (PRR), outward while encapsulating R353 in the molecule. The outward directed positively charged patches are likely to be involved in binding to anionic surfaces. The binding of FXII to surfaces (and several monoclonal antibodies) acccelerates its activation by inducing conformational changes. For prevention of medical device associated thrombosis, it is therefore important to target the surface binding sites of FXII without causing structural changes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252566109,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1055\/a-1951-1777","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The 3p\u20092B1\u2190\u2190X\u20092B1 bands of CH2D and CHD2 radicals were observed between 305 and 335 nm by mass resolved, 2+1 resonance enhanced multiphoton ionization spectroscopy. Spectroscopic constants were found for the 3p\u20092B1 Rydberg state of the CH2D radical (\u03bd00=59\u2009940 cm\u22121, \u03bd1a1 CH2 stretch=2995 cm\u22121, \u03bd2a1 CD stretch=2220 cm\u22121, \u03bd4b1 out\u2010of\u2010plane large amplitude (OPLA)=1260 cm\u22121, \u03bd5b2 CH2 asymmetric stretch=3055 cm\u22121, \u03bd6b2 CD bend=1115 cm\u22121) and of the CHD2 radical (\u03bd00=59\u2009920 cm\u22121, \u03bd1a1 CH stretch=3040 cm\u22121, \u03bd2a1 CD2 stretch=2150 cm\u22121, \u03bd4b1 OPLA=1165 cm\u22121, \u03bd6b2 CH bend=1210 cm\u22121). Vibrational frequencies calculated by ab initio theory agree well with the experimental data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":196949475,"openaccessinfo":{"externalids":{"MAG":"2952625576","ACL":null,"DOI":"10.1002\/CHIN.199333036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT This paper investigates how Dutch education professionals and Ghanaian migrant youth frame the impact of young people's geographical mobility on education. The paper is based on a discourse analysis of policy documentation, semi-structured interviews with education professionals and 20 months of multi-sited ethnographic fieldwork with 30 young Ghanaians (ages 16\u201325). The analyses show that the relationship between mobility and education has historically been problematized in the Netherlands, now permeating negative framings of mobility adopted by Dutch education professionals. Young Ghanaians, however, envision their mobility and education as positively intertwined. The comparison shows that education professionals and young Ghanaians employ frames that conflict because they draw on distinctly different notions of 'education' and because dominant framings produce uncompromising narratives, realities, and eventually policies.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":248300892,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/17508487.2019.1650382","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17508487.2019.1650382?needAccess=true","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Background The melanocortin 4 receptor (MC4R) critically regulates feeding and satiety. Rare variants in MC4R are predominantly found in obese individuals. Though some rare variants in MC4R discovered in patients have defects in localization, ligand binding and signaling to cAMP, many have no recognized defects. Subjects\/Methods In our cohort of 1433 obese subjects that underwent Roux-en-Y Gastric Bypass (RYGB) surgery, we found fifteen variants of MC4R. We matched rare variant carriers to patients with the MC4R reference alleles for gender, age, starting BMI and T2D to determine the variant effect on weight-loss post-RYGB. In vitro, we determined expression of mutant receptors by ELISA and western blot, and cAMP production by microscopy. Results While carrying a rare MC4R allele is associated with obesity, carriers of rare variants exhibited comparable weight-loss after RYGB to non-carriers. However, subjects carrying three of these variants, V95I, I137T or L250Q, lost less weight after surgery. In vitro, the R305Q mutation caused a defect in cell surface expression while only the I137T and C326R mutations showed impaired cAMP signaling. Despite these apparent differences, there was no correlation between in vitro signaling and pre- or post-surgery clinical phenotype. Conclusions These data suggest that subtle differences in receptor signaling conferred by rare MC4R variants combined with additional factors predispose carriers to obesity. In the absence of complete MC4R deficiency, these differences can be overcome by the powerful weight-reducing effects of bariatric surgery. In a complex disorder such as obesity, genetic variants that cause subtle defects that have cumulative effects can be overcome after appropriate clinical intervention.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":2762658,"openaccessinfo":{"externalids":{"MAG":"2063106292","ACL":null,"DOI":"10.1371\/journal.pone.0093629","PubMedCentral":"3976318","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0093629&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"To estimate the incidence of Lyme borreliosis in France, describe its clinical presentations, and assess its potential risk factors, we conducted a nationwide prospective study in the French Sentinelles Network, consisting of 1178 general practitioners (GPs). Of these, 875 (74%), i.e. 1\u00b76% of all French GPs, participated in the study from May 1999 to April 2000. Eighty-six cases of Lyme disease were reported and validated, of which 77 (90%) consisted of erythema migrans. At national level, the incidence was estimated at 9\u00b74\/100000 inhabitants. Compared to the French general population, Lyme disease patients were older (P<10\u22124), more were living in rural areas (P<10\u22123), and amongst the working population, more were farmers (P<10\u22123) and fewer, salaried workers (P<0\u00b7005). Cervidae density correlated strongly with the estimated regional incidence of Lyme disease (r=0\u00b782). Both incidence data and identified risk factors can help to target measures for its prevention and treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27392418,"openaccessinfo":{"externalids":{"MAG":"2093125513","ACL":null,"DOI":"10.1017\/S0950268805004413","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recommender systems research is being slowed by the difficulty of replicating and comparing research results. Published research uses various experimental methodologies and metrics that are difficult to compare. It also often fails to sufficiently document the details of proposed algorithms or the evaluations employed. Researchers waste time reimplementing well-known algorithms, and the new implementations may miss key details from the original algorithm or its subsequent refinements. When proposing new algorithms, researchers should compare them against finely-tuned implementations of the leading prior algorithms using state-of-the-art evaluation methodologies. With few exceptions, published algorithmic improvements in our field should be accompanied by working code in a standard framework, including test harnesses to reproduce the described results. To that end, we present the design and freely distributable source code of LensKit, a flexible platform for reproducible recommender systems research. LensKit provides carefully tuned implementations of the leading collaborative filtering algorithms, APIs for common recommender system use cases, and an evaluation framework for performing reproducible offline evaluations of algorithms. We demonstrate the utility of LensKit by replicating and extending a set of prior comparative studies of recommender algorithms --- showing limitations in some of the original results --- and by investigating a question recently raised by a leader in the recommender systems community on problems with error-based prediction evaluation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":2215419,"openaccessinfo":{"externalids":{"MAG":"2161351857","ACL":null,"DOI":"10.1145\/2043932.2043958","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"PurposeWe aimed to determine the effect of surgical compliance on prognosis in patients with osteosarcoma and the risk factors leading to surgical noncompliance.MethodsWe analyzed the date collected 3412 osteosarcoma patients from the Surveillance Epidemiology and End Results (SEER) databases between 1973 and 2015. Cox analyses were used to identify the independent prognostic factors. Logistic regression model was conducted to clear the factors associated to surgical compliance; Kaplan-Meier estimator method was adopted to analyze the Overall survival (OS) and Cancer-specific survival (CSS). ResultsAmong 3412 eligible osteosarcoma patients, the poor surgical compliance of patients with osteosarcoma is associated with the earlier time of diagnosis, advanced age, lower economic income, poor grade, distant stage, accepting radiotherapy and refusing chemotherapy. There were significant differences in the effects of diagnostic time, age, grade, radiotherapy, chemotherapy, tumor stage and economic income on surgical compliance (All P < 0.05). Patients' compliance was an independent prognostic factor for OS and CSS of osteosarcoma patients. ConclusionsOsteosarcoma patients with good surgical compliance have favorable survival. This can help clinicians effectively realize patients' views on surgery and guide patients to learn the signification of surgery.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238764786,"openaccessinfo":{"externalids":{"MAG":"3188405036","ACL":null,"DOI":"10.21203\/rs.3.rs-754287\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-754287\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Introduction\n As a rare form of non-Hodgkin's lymphoma, mantle cell lymphoma (MCL) is an aggressive subtype. This is largely due to frequent relapses after therapies including paradigm shifting therapies BTK inhibitors (BTKi), such as ibrutinib and acalabrutinib, and Bcl-2 inhibitor (Bcl-2i) venetoclax after long-term treatment in the clinic. Dysregulation of Bcl-2 and Bcl-X L, contributes to therapeutic resistance in MCL. AZD0466 is a novel and highly potent Bcl-2\/X L dual inhibitor with active moiety AZD4320. Our preliminary data showed AZD4320 is potent in inhibiting cell viability of MCL cells (IC 50 = 1.6-78 nM). In this study, we assessed the combination efficacy of AZD4320\/AZD0466 and acalabrutinib on preclinical MCL models.\n Methods\n Cell viability assay was performed to assess the in vitro efficacy of AZD4320 and acalabrutinib alone or in combination in a panel of ibrutinib\/venetoclax-sensitive and -resistant MCL cell lines. Cell apoptosis assay was also performed to determine if AZD4320 and acalabrutinib enhanced cell death by cell apoptosis in MCL cell lines. Protein expression profiles of a panel of pro- and anti-apoptotic proteins and other relevant proteins were detected by immunoblotting. Since AZD4320 is limited in preclinical model due to physicochemical properties and dose limiting cardiovascular toxicity, AZD0466, the drug-dendrimer conjugate of AZD4320, was used for in vivo experiment. In vivo efficacy of AZD0466 (34 mg\/kg, weekly, iv) and acalabrutinib (20 mg\/kg, BID, oral) alone or in combination was evaluated using a Mino-venetoclax-R (Mino-R) cell xenograft model and a PDX model derived from an ibrutinib-CAR-T dual-resistant MCL patient.\n Results\n AZD4320 in combo with acalabrutinib inhibited cell proliferation synergistically in both ibrutinib\/venetoclax-sensitive and -resistant cell lines (combination index = 0.17-0.93). Compared to vehicle or either single agent, the combination enhanced cell apoptosis by increasing pro-apoptotic markers cleaved caspase 3 and cleaved PARP. In the xenograft mouse model derived from venetoclax-resistant Mino-R cells, co-treatment of AZD0466 and acalabrutinib decreased tumor size significantly compared to vehicle (n = 5, p < 0.0001) or either single agent (n = 5, p = 0.0118 and 0.0070, respectively). Furthermore, in the PDX mouse model derived from a patient relapsed subsequently from ibrutinib and CAR T therapy, the combination of AZD0466 and acalabrutinib inhibited tumor growth compared to vehicle or either single agent. Acalabrutinib or AZD0466 improved survival compared with vehicle by 14 days or 32 days, respectively. Compared to Acalabrutinib or AZD0466, the combination therapy extended survival by 25 days and 7 days, respectively. All mice tolerated the treatment dose without any weight loss compared to the vehicle or either single agent group.\n Conclusion\n Compared to AZD4320\/AZD0466 and acalabrutinib, combination therapy demonstrated anti-MCL synergy both in vitro and in vivo. These findings suggest that targeting Bcl-2\/X L and BTK is promising to overcome multiple acquired resistance phenotypes, including CD19 CAR T-cell therapy.\n \n \n Andersen:\u2008AstraZeneca: Current Employment, Current equity holder in publicly-traded company. Cidado:\u2008AstraZeneca: Current Employment, Current equity holder in publicly-traded company. Wang:\u2008DTRM Biopharma (Cayman) Limited: Consultancy; BeiGene: Consultancy, Honoraria, Research Funding; Physicians Education Resources (PER): Honoraria; Anticancer Association: Honoraria; Janssen: Consultancy, Honoraria, Research Funding; CAHON: Honoraria; The First Afflicted Hospital of Zhejiang University: Honoraria; Epizyme: Consultancy, Honoraria; AstraZeneca: Consultancy, Honoraria, Research Funding; BGICS: Honoraria; Imedex: Honoraria; Clinical Care Options: Honoraria; Celgene: Research Funding; Genentech: Consultancy; Loxo Oncology: Consultancy, Research Funding; InnoCare: Consultancy, Research Funding; Molecular Templates: Research Funding; Lilly: Research Funding; VelosBio: Consultancy, Research Funding; BioInvent: Research Funding; Oncternal: Consultancy, Research Funding; OMI: Honoraria; Newbridge Pharmaceuticals: Honoraria; Scripps: Honoraria; Hebei Cancer Prevention Federation: Honoraria; Chinese Medical Association: Honoraria; Pharmacyclics: Consultancy, Research Funding; Juno: Consultancy, Research Funding; CStone: Consultancy; Bayer Healthcare: Consultancy; Miltenyi Biomedicine GmbH: Consultancy, Honoraria; Kite Pharma: Consultancy, Honoraria, Research Funding; Acerta Pharma: Consultancy, Honoraria, Research Funding; Dava Oncology: Honoraria; Moffit Cancer Center: Honoraria; Mumbai Hematology Group: Honoraria.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":244559487,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1182\/blood-2021-151609","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1182\/blood-2021-151609","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Purpose: Ultrasound-guided transversus abdominis plane (TAP) blocks have been demonstrated to decrease postoperative pain; however, laparoscopic-assisted TAP (L-TAP) blocks have not been well studied in children. Our study utilized intraoperative ultrasound to verify whether surgeon-administered blocks using only laparoscopic visualization were reliably delivered into the correct plane. Materials and Methods: Patients undergoing laparoscopic procedures were enrolled to receive L-TAP blocks. Preblock and postblock ultrasounds were performed to document the plane of local anesthetic delivery. Ultrasound images were reviewed by two blinded anesthesiologists to determine whether the L-TAP block was administered into the desired plane. Results: Fifty-one patients were enrolled. The average age was 5.9 years (range: 2 days to 17 years) and the mean weight was 25.4\u2009kg (range: 2.64-118.8\u2009kg). The most common procedures were inguinal hernia repair (n\u2009=\u200919), appendectomy (n\u2009=\u200910), and gastrostomy-tube placements (n\u2009=\u200913). Nine surgeons performed 93\u2009L-TAP blocks (average: 10.3 blocks\/surgeon). Ultrasound confirmed distribution in the correct plane in 53.5\/93 blocks (57.5%; 58.0% for attending surgeons), with 77.4% concurrence between the anesthesiologist reviewers. Conclusion: L-TAP achieves delivery of local anesthetic into the correct tissue plane in over half the cases with minimal training. Further studies are needed to examine the effect of L-TAP blocks on reducing postoperative pain in pediatric patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245544519,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1089\/lap.2020.0994","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a 4-ways passive power splitter\/combiner based on Wilkinson dividers implemented in the BEOL of a conventional 28nm bulk CMOS process achieving better than -20 dB of isolation and 2.5 dB of insertion loss across 25 GHz of band at 140 GHz","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208281345,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.23919\/EuMC.2019.8910855","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The idea behind both the Appropriate Education Act (in Dutch: \"Passend Onderwijs\") and the Youth Act is that more children receive regular education, as well as help and support adjusted to their living circumstances. This is also the essence of inclusive education. According to the researcher of this thesis, this requires a shift from an individual biomedical view to a more context-oriented view of pupil behavior. This thesis is focused on contextual factors of teachers' perception of pupil behavior in classroom. The studies show that the teacher's perception of the individual pupil's behavior is influenced by the number of children in the classroom that is considered problematic and the number of boys in the classroom. The research also shows that teachers' perception can be influenced by the implementation of a school-wide behavioral approach, although the degree to which varies from teacher to teacher. Further, it shows that one group of teachers does not see any benefits to an ADHD-diagnosis in their teaching practice, while a significant group of other teachers mainly sees benefits, for example because after a diagnosis good contact with the parents is restored. The researcher concludes that how teachers assess the behavior of children in the classroom cannot be separated from the context, and that teachers differ significantly in terms of the perception of pupil behavior. The researcher suggests that if insufficient attention is paid to the context in which the teacher works, this will lead to even more children with diagnoses and teachers experiencing work pressure.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":197709446,"openaccessinfo":{"externalids":{"MAG":"2952476757","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"O-linked oligosaccharide-alditols were analyzed by a combination of high-performance liquid chromatography (HPLC) and electrospray-tandem mass spectrometry (ESI-MS\/MS). First, oligosaccharide-alditols were treated with sodium meta-periodate under conditions where core N-acetylgalactosaminitol is specifically degraded. The resulting fragments were labeled with 2-aminopyridine and purified on a reversed-phase column. Pyridylamino oligosaccharides yielded protonated molecular ions in positive-ion ES-MS and gave Y-series sequence ions, arising from glycosidic cleavages, by ESI-tandem mass spectrometry. Information on sugar sequence and branching of oligosaccharides linked at C6 and C3 to the N-acetylgalactosaminitol can be obtained. A systematic study of various oligosaccharide-alditols demonstrated that this approach constitutes a powerful tool for the structural characterization of O-glycans available only in limited quantities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42409091,"openaccessinfo":{"externalids":{"MAG":"2073448867","ACL":null,"DOI":"10.1006\/ABIO.1998.2618","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we present a direct adaptive control method for a class of uncertain nonlinear systems with a time-varying structure. We view the nonlinear systems as composed of a finite number of ``pieces,'' which are interpolated by functions that depend on a possibly exogenous scheduling variable. We assume that each piece is in strict feedback form, and show that the method yields stability of all signals in the closed-loop, as well as convergence of the state vector to a residual set around the equilibrium, whose size can be set by the choice of several design parameters. The class of systems considered here is a generalization of the class of strict feedback systems traditionally considered in the backstepping literature. We also provide design guidelines based on L-infinity bounds on the transient.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14626744,"openaccessinfo":{"externalids":{"MAG":"1711003532","ACL":null,"DOI":"10.1109\/9.898709","PubMedCentral":null,"ArXiv":"math\/0007168"},"license":null,"url":"http:\/\/ece.osu.edu\/~passino\/PapersToPost\/ACNLTV-TAC.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This experimental study, first, compares the individual valuations of two risk reduction mechanisms: self-insurance and self-protection. Second, it investigates these valuations when the loss amount is ambiguous, and compare these values with valuations when loss amounts are known. results confirm that there exists no \"framing effect\" due to the two risk reduction mechanisms. Ambiguity in the loss amount has a weak impact on the valuation, and using different representations of ambiguity does not change the valuation. Moreover, the mean ratios of ambiguous to risky bids are greater than one for low loss amounts indicating ambiguity aversion. These ratios are not significantly different from one for high loss amounts regardless of the probability of loss levels. Finally, 28 percent of the sample behaved consistent with the predictions of \"anchoring and adjustment\", while only 6 percent supported the \"maximin\" predictions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":18870803,"openaccessinfo":{"externalids":{"MAG":"2152862343","ACL":null,"DOI":"10.2139\/ssrn.1021177","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www2.wiwi.uni-jena.de\/Papers\/jerp2007\/wp_2007_034.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The Western Tradition, 5\/e, offers carefully selected documents reflecting the social, political, economic, cultural, and religious development of Western civilization. Volume I spans the rise of Western civilization from Egypt and Mesopotamia to the seventeenth century. Volume II commences with the Renaissance and Reformation and it culminates with the end of the Cold War and the rise of new nationalist movements.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":153960747,"openaccessinfo":{"externalids":{"MAG":"1569892373","ACL":null,"DOI":"10.2307\/j.ctt1pv897r.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In an accompanying paper it is shown that theoretically a zero-variance Monte Carlo scheme can be devised for criticality calculations if the space, energy and direction dependent adjoint function is exactly known. This requires biasing of the transition and collision kernels with the appropriate adjoint function. In this paper it is discussed how an existing general purpose Monte Carlo code like TRIPOLI can be modified to approach the zero-variance scheme. This requires modifications for reading in the adjoint function obtained from a separate deterministic calculation for a number of space intervals, energy groups and discrete directions. Furthermore, a function has to be added to supply the direction dependent and the averaged adjoint function at a specific position in the system by interpolation. The initial particle weights of a certain batch must be set inversely proportional to the averaged adjoint function and proper normalization of the initial weights must be secured. The sampling of the biased transition kernel requires cumulative integrals of the biased kernel along the flight path until a certain value, depending on a selected random number is reached to determine a new collision site. The weight of the particle must be adapted accordingly. The sampling of the biased collision kernel (in a multigroup treatment) is much more like the normal sampling procedure. A numerical example is given for a 3-group calculation with a simplified transport model (two-direction model), demonstrating that the zero-variance scheme can be approximated quite well for this simplified case.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":124750067,"openaccessinfo":{"externalids":{"MAG":"2266152171","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Building on the one hand on the link between immersion and peripheral vision, and on the other hand on the visually induced perceptual illusion of self-motion (vection), the author examines synesthesia through the relationship between peripheral vision and proprioception. The author maintains that immersion in installations results from multimodal perception grounded in motor-sensory activity, and he considers installations and scenographies in which the viewer's peripheral vision, balance, motion and posture play an important role.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":57563994,"openaccessinfo":{"externalids":{"MAG":"2333405497","ACL":null,"DOI":"10.1162\/LEON_a_01008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The recycling of reclaimed asphalt pavement (RAP) is typically achieved by adding a rejuvenating agent into the mix. The addition of the rejuvenating agent leads to adjusting the compositions and consequently improving the physical and performance properties of the rejuvenated aged binders in the RAP. Many rubberized pavements, around the country, are over 15 years old and some of them are a candidate for recycling. Therefore, there is a need to study the effects of rejuvenating agents on aged crumb rubber modified binders (CRM binders). This paper presents a study characterizing the blends of laboratory-aged CRM binders and rejuvenating agents using gel permeation chromatography (GPC), resulting in the development of empirical models to predict selected properties of the blends. Three aged CRM binders and two aged control binders (PG 76-22) were mixed with either a rejuvenator or a softer binder at different concentrations to determine the influence of the various asphalt binders and the rejuvenating agents on the chromatographic profiles. The results indicated the compositional changes of the blends containing various percentages of either the rejuvenator or the softer binder are well reflected by the GPC profiles. The large molecular size (LMS) of the blends decreased and the small molecular size (SMS) increased as the percentage of the rejuvenator agents increased regardless of the type of aged binders or the rejuvenating agents. The empirical prediction models for Superpave binder properties (viscosity and high-failure temperature) were developed using LMS and SMS. The predicted values showed a high correlation with the viscosity and the high-failure temperature of binders.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2015-11":1,"2015-18":1}},"corpusid":137272523,"openaccessinfo":{"externalids":{"MAG":"2046169165","ACL":null,"DOI":"10.1061\/(ASCE)0899-1561(2007)19:6(515)","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Locomotion and foraging on the wing require precise navigation in more than just the horizontal plane. Navigation in three dimensions and, specifically, precise adjustment of flight height are essential for flying animals. Echolocating bats drink from water surfaces in flight, which requires an exceptionally precise vertical navigation. Here, we exploit this behavior in the bat, Phyllostomus discolor, to understand the biophysical and neural mechanisms that allow for sonar-guided navigation in the vertical plane. In a set of behavioral experiments, we show that for echolocating bats, adjustment of flight height depends on the tragus in their outer ears. Specifically, the tragus imposes elevation-specific spectral interference patterns on the echoes of the bats' sonar emissions. Head-related transfer functions of our bats show that these interference patterns are most conspicuous in the frequency range \u223c55 kHz. This conspicuousness is faithfully preserved in the frequency tuning and spatial receptive fields of cortical single and multiunits recorded from anesthetized animals. In addition, we recorded vertical spatiotemporal response maps that describe neural tuning in elevation over time. One class of units that were very sharply tuned to frequencies \u223c55 kHz showed unusual spatiotemporal response characteristics with a preference for paired echoes where especially the first echo originates from very low elevations. These behavioral and neural data provide the first insight into biosonar-based processing and perception of acoustic elevation cues that are essential for bats to navigate in three-dimensional space.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":18772405,"openaccessinfo":{"externalids":{"MAG":"2070038222","ACL":null,"DOI":"10.1152\/jn.00263.2014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The European Higher Education Area (EHEA) requires the student a more autonomous work. This autonomy is related to the outcome of the self-regulated learning process. The self-regulation involves a self-management skill set coping with any adverse contingency and entails the knowledge of the available abilities and the personal control to put in action those skills. The learning self-regulation serves as a critical process to develop learning to learn competences that enable to transform the mental aptitudes into academic competences. However, it is necessary to make modifications of the learning conditions to achieve it in an adequate way. Thus, the academic authorities should empower skills that facilitate autonomous learning as well as contribute with tools to the student proactivity. In this sense, the problem-based learning is an effective method to facilitate the acquisition of transversal competences. This didactic methodology may be performed in terms of individual or team-based-learning (TBL) that is necessary linked to a teaching-learning open system. An adaptation of the PBL to the thermal engineering studies, the project based learning model, was designed to the 'Building Energetic Efficiency' subject of the Research Master.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":58935472,"openaccessinfo":{"externalids":{"MAG":"2161904471","ACL":null,"DOI":"10.3926\/JOTSE.81","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo investigate inter- and intra-individual variation in the levels and outputs (concentration multiplied by salivary flow rate) of salivary metabolites in patients with primary Sj\u00f6gren's syndrome (pSS).\n\n\nMETHODS\nA total of 56 samples of stimulated saliva were collected from 14 female pSS patients during four laboratory visits within 20 weeks and analyzed using proton nuclear magnetic resonance spectroscopy. Single saliva samples from each of 15 controls were also analyzed.\n\n\nRESULTS\nAmong 21 quantified metabolites, choline was significantly elevated in the pSS patients at each time point (P \u2264 0.015), taurine at the last three time points (P \u2264 0.013), alanine at the last two time points (P \u2264 0.007) and glycine at the last time point (P = 0.005). Inter-individual variation in metabolite concentrations was generally larger among the patients than among the controls, and significantly large variations were observed for glycine (P \u2264 0.007, all time points), choline (P \u2264 0.033, three last time points) and alanine (P = 0.028, baseline). Metabolite output analysis showed that choline had the lowest intra-patient variation.\n\n\nCONCLUSION\nIn spite of considerable intra- and inter-individual variation, levels and outputs of specific metabolites in patients with pSS differ from those in controls, and may be potentially applicable as new biological markers for monitoring of the response to treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":226045181,"openaccessinfo":{"externalids":{"MAG":"3096615627","ACL":null,"DOI":"10.2334\/josnusd.19-0504","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/63\/1\/63_19-0504\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This article investigates the corpus-based discourse study of the representations of smog documentary Under the Dome in five Chinese media (Xinhua News, People's Daily, China News, Guangming Daily and Caijing Net) and four American media (The New York Times, The Wall Street Journal, The Washington Post and USA Today). It is found that dialectical relationship between discourse and culture, discourse and politics as exemplified by the historical issues, various linguistic forms and discursive strategies. The findings suggest that Chinese media discourse about Chai's smog documentary tends to be unitary, while American media discourse focuses on the whole story of the event and constructs an integrated discourse event with diverse perspectives. American news reports inclined to take a determinative attitude to accuse Chinese government' censorship while Chinese news report focuses on expressing people's emotion and opinion toward the smog documentary and Chai Jing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53602828,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The highest performance flow cells capable of electrolytically converting CO2 into higher value chemicals and fuels pass a concentrated hydroxide electrolyte across the cathode. A major problem for CO2 electrolysis is that this strongly alkaline medium converts the majority of CO2 into unreactive HCO3\u2013 and CO32\u2013 rather than CO2 reduction reaction (CO2RR) products. The electrolysis of CO (instead of CO2) does not suffer from this same problem because CO does not react with hydroxide. Moreover, CO can be more readily converted into products containing two or more carbon atoms (i.e., C2+ products). While several solid-state electrocatalysts have proven competent at converting CO into C2+ products, we demonstrate here that molecular electrocatalysts are also effective at mediating this transformation in a flow cell. Using a molecular copper phthalocyanine (CuPc) electrocatalyst, CO was electrolyzed into C2+ products at high rates of product formation (i.e., current densities J \u2265200 mA\/cm2), and at high Faradaic efficiencies for C2+ production (FEC2+; 72% at 200 mA\/cm2). These findings present a new class of electrocatalysts for making carbon-neutral chemicals and fuels.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":234641748,"openaccessinfo":{"externalids":{"MAG":"3120054629","ACL":null,"DOI":"10.21203\/rs.3.rs-83176\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-83176\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Objective: Examinations by using tests are very frequently used in educational settings and successful studying before the examinations is a complex matter to deal with. In order to understand the determinants of success in exams better, we need to take into account not only emotional and motivational, but also cognitive aspects of the participants such as dysfunctional beliefs. Our aim is to present the relationship between candidates' characteristics and distorted beliefs\/schemata just before an examination. \nMethod: The subjects of the study were 30 female and 30 male physicians who were about to take the medical specialization exam (MSE) in Turkey. Dysfunctional Attitude Scale (DAS) and Young Schema Questionnaire Short Form (YSQ-SF) were applied to the subjects. The statistical analysis was done using the F test, Mann-Whitney, Kruskal-Wallis, chi-square test and spearman's correlation test. \nResults: It was shown that some of the DAS and YSQ-SF scores were significantly higher in female gender, in the group who could not pass the exam, who had repetitive examinations, who had their first try taking an examination and who were unemployed at the time of the examination. \nConclusion: Our findings indicate that candidates seeking help before MSE examination could be referred for cognitivetherapy or counseling even they do not have any psychiatric diagnosis due to clinically significant cognitive distortion.Measurement and treatment of cognitive distortions that have negative impact on MSE performance may improve thecost-effectiveness and mental well being of the oung doctors.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":141330693,"openaccessinfo":{"externalids":{"MAG":"124574214","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The role of a spin-dependent electronic structure in the giant magnetoresistance effect (GMR) of metallic magnetic multilayers is considered. The general transmission amplitude (coefficient) for an electron Bloch wave passing from one magnetic layer to another one through a nonmagnetic spacer in the ballistic regime is found for the case of perfect interfaces. The Boltzmann equation, which incorporates this transmission coefficient and spin dependent scattering (SDS) in a bulk of magnetic layers, is solved for a magnetic multilayer in the current-in-plane (CIP) geometry. It is shown that, if there is no spin asymmetry in an electron scattering by imperfections, an electron refraction (a difference in the electron velocities in different layers\/different sheets of the Fermi surface) itself results in a negative magnetoresistance and thus can lead to an enhancement of the GMR. The interference of electronic waves leads to the oscillations of the magnetoresistance as a function of the spacer thickness. These oscillations can survive an integration over the Fermi surface and their periods are determined by the stationary vectors of the spacer Fermi surface. The oscillating quantum corrections are calculated explicitly. A new approach to accounting for imperfections of the interfaces is proposed. The general formula for the magnetoresistance, which accounts for both the coherent and diffuse electron scattering at the interfaces, is obtained.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250846775,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/33\/11\/304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present measurements of elliptic flow ($v_2$) of electrons from the decays of heavy-flavor hadrons ($e_{HF}$) by the STAR experiment. For Au+Au collisions at $\\sqrt{s_{\\rm NN}} = $ 200 GeV we report $v_2$, for transverse momentum ($p_T$) between 0.2 and 7 GeV\/c using three methods: the event plane method ($v_{2}${EP}), two-particle correlations ($v_2${2}), and four-particle correlations ($v_2${4}). For Au+Au collisions at $\\sqrt{s_{\\rm NN}}$ = 62.4 and 39 GeV we report $v_2${2} for $p_T<2$ GeV\/c. $v_2${2} and $v_2${4} are non-zero at low and intermediate $p_T$ at 200 GeV, and $v_2${2} is consistent with zero at low $p_T$ at other energies. The $v_2${2} at the two lower beam energies is systematically lower than at $\\sqrt{s_{\\rm NN}} = $ 200 GeV for $p_T<1$ GeV\/c. This difference may suggest that charm quarks interact less strongly with the surrounding nuclear matter at those two lower energies compared to $\\sqrt{s_{\\rm NN}} = 200$ GeV.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119300433,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1103\/PhysRevC.95.034907","PubMedCentral":null,"ArXiv":"1405.6348"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This project aims to investigate the previously undescribed English variety spoken by travelling Showpeople in England. Travelling Showpeople are a cultural group who live a nomadic lifestyle due to their occupation which mainly entails operating travelling funfairs. Despite the fact that funfairs are an important event in the calendar of most English towns and cities, very little is known about the community behind the candyfloss stalls or dodgems. They are described as an extremely close-knit, family-centred community who have little contact with the settled population. \n \nWhy is it important to analyse a dialect spoken by a community \"operating on the fringes of \nsociety\" (Toulmin 2003: 61)? Firstly, English dialectology has tended to shun nomadic speakers since they are often not deemed to represent authentic speakers of a place. Despite \nthe existence of various nomadic groups in England, there has always been a strong focus on \ngeographical continuity and local embeddedness, although studies on nonlocal mobile members of the community have highlighted their importance in influencing and understanding language change (e.g. Cheshire\/Kerswill\/Fox\/Torgersen 2011; Horvath 1985, summarised in Britain 2016). The study of the Showpeople's dialect allows us to analyse the influence of routine forms of mobility on the establishment of community dialect norms. Secondly, the Travelling Showpeople are a relatively isolated community with a distinctive lifestyle. Analysing their dialect will enable us to theorise to what extent such speakers are able to acquire sedentary dialect norms and how language change enters such communities and is transmitted from one generation to the next. \n \nHere, I will briefly introduce you to this research project. In particular, I will present, question and discuss the methodological practicalities of it.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":150349751,"openaccessinfo":{"externalids":{"MAG":"2906272550","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fifty patients undergoing phacoemulsification with posterior chamber intraocular lens implantation were randomly assigned to receive either diclofenac sodium 0.1% eye drops (Voltaren Ophthalmic, CibaVision Ophthalmics, Duluth, GA) or prednisolone acetate 1.0% eye drops (Pred Forte, Allergan Pharmaceuticals, Irvine, CA) as their postoperative anti-inflammatory medication. The patients were examined one day, one week, and one month after surgery, and their postoperative inflammation was evaluated both by slit lamp assessment of cell and flare, and by objective measurement of cell and flare with the Kowa FC-1000 laser cell and flare meter. At each visit, the level of postoperative inflammation was the same for the two study groups. Thus diclofenac sodium was as effective an anti-inflammatory agent for postoperative inflammation as prednisolone acetate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6135266,"openaccessinfo":{"externalids":{"MAG":"2465948740","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Icarus detector is a liquid Argon Time Projection Chamber that requires continuous signal recording for each channel to provide three dimensional images of any ionizing event. A complete drift volume imaging of the next 600 ton module will result in 1.15 Gbit, with a data rate of 1.15 Tbit\/s. The collected data can be highly reduced by recognizing Regions Of Interest (ROI) of the signal by means of a custom hit finding unit (DAEDALUS) working pipelined in the data acquisition path. DAEDALUS is an ASIC that implements an algorithm developed for hit detection and proven to be very efficient both on real and on simulated data. Since only ROI's are saved in memory and contiguous regions can be correlated to enhance detector self triggering capability, a high efficiency zero skipping is obtained in real time. A VME board hosting 16 Icarus digital channels has been designed and built as a demonstrator for functionality and performance test. The board, named ARIANNA, and DAEDALUS chip are here presented in detail.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":110198125,"openaccessinfo":{"externalids":{"MAG":"2171730769","ACL":null,"DOI":"10.1109\/23.710940","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction Tension-type headache (TTH) is the most prevalent neurological disease, with an estimated 1.5\u2009billion cases worldwide. Pharmacotherapy should be considered by patients with TTH who have a limited response to non-pharmacological treatment. However, recommendations for the vast array of therapeutic drugs for TTH partially overlap, with conflicting recommendations for strength in different guidelines; these may confuse the decision-making process of clinicians. Hence, the aims of this study are to analyse the available direct and indirect evidence on different drug monotherapies for TTH in adults, and to generate a treatment ranking according to their efficacy and safety outcomes by using a Bayesian network meta-analysis (NMA). Methods and analysis We will systematically search the Cochrane Library, PubMed, Web of Science, Embase, China Biomedical Literature Database, International Clinical Trials Registry Platform and other resources for eligible studies. Randomised controlled trials on different drug monotherapies for TTH will be included. Two review authors (RX and YW) will independently search and select the studies, extract the data and assess the risk of bias. A Bayesian NMA will afterwards be conducted to pool the effect measures across all types of monotherapy drugs. The ranking probabilities of the efficacy and safety of different drug monotherapies will be estimated. Heterogeneity will be quantified using the Q statistic and the I\u00b2 index. Inconsistency between direct and indirect evidence will be assessed by the node-splitting model. In addition, the overall quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. Ethics and dissemination No ethical issues are foreseen. The results will be published in a peer-reviewed journal, which will be disseminated electronically and in print. PROSPERO registration number CRD42018090554.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58623065,"openaccessinfo":{"externalids":{"MAG":"2909446189","ACL":null,"DOI":"10.1136\/bmjopen-2018-023748","PubMedCentral":"6340443","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/9\/1\/e023748.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The main advantage of Microwave Kinetic Inductance Detector arrays (MKID) is their multiplexing capability, which allows for building cameras with a large number of pixels and good sensitivity, particularly suitable to perform large blank galaxy surveys. However, to have as many pixels as possible it is necessary to arrange detectors close in readout frequency. Consequently KIDs overlap in frequency and are coupled to each other producing crosstalk. Because crosstalk can be only minimised by improving the array design, in this work we aim to correct for this effect a posteriori. We analysed a MKID array consisting of 880 KIDs with readout frequencies at 4-8 GHz. We measured the beam patterns for every detector in the array and described the response of each detector by using a two-dimensional Gaussian fit. Then, we identified detectors affected by crosstalk above -30 dB level from the maximum and removed the signal of the crosstalking detectors. Moreover, we modelled the crosstalk level for each KID as a function of the readout frequency separation starting from the assumption that the transmission of a KID is a Lorenztian function in power. We were able to describe the general crosstalk level of the array and the crosstalk of each KID within 5 dB, so enabling the design of future arrays with the crosstalk as a design criterion. In this work, we demonstrate that it is possible to process MKID images a posteriori to decrease the crosstalk effect, subtracting the response of each coupled KID from the original map.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":115522826,"openaccessinfo":{"externalids":{"MAG":"3105781511","ACL":null,"DOI":"10.1117\/12.2238643","PubMedCentral":null,"ArXiv":"1609.00163"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1609.00163","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This article aims at defining the concept of 'semi-presidential government' and detailing the diversity of its practices. There are in fact three types of semi-presidential regimes: the president can be a mere figurehead, or he may be all-powerful or again he can share his power with parliament. Using four parameters -- the content of the constitution, tradition and circumstances, the composition of the parliamentary majority and the position of the president in relation to the majority -- the author seeks to explain why similar constitutions are applied in a radically different manner.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144299677,"openaccessinfo":{"externalids":{"MAG":"2067521803","ACL":null,"DOI":"10.1111\/J.1475-6765.1997.TB00769.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper investigates the adaptive group consensus of multiple robotic manipulator systems in task space under directed acyclic graph topology. Two adaptive control strategies are proposed based on parameters linearity method and neural network method, respectively. The criteria for solving group consensus problems are established by using Lyapunov approach. It is shown that, under some reasonable assumptions, the group consensus of multiple robotic manipulator systems can always be achieved by the structure of acyclic interaction topology in task space. Finally, numerical simulations are given to demonstrate the effectiveness of the proposed control methodologies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12302241,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/chicc.2016.7554670","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background The initial symptoms of Adult-onset Still Disease (AOSD) are non-specific and confusing with those of common cold, which can lead to the delay of diagnosis and treatment. Objectives To clarify characteristic features in AOSD in very early phase and to find the key symptoms and markers to an earlier diagnosis and treatment. Methods We retrospectively reviewed consecutive AOSD patients in our hospital from April 2012 to July 2017. Symptoms and laboratory data before treatment were collected form their charts and analysed. Results A total of 62 patients were enrolled. The mean age at diagnosis was 45.9 and female was 81%. The duration from the first symptoms to the first visit to a medical facility was 18.7 days, from the first visit to the first blood test was 5.8 days, from the first blood test to the fulfilment of Yamaguchi's Criteria was 11.0 days, and from the fulfilment of Yamaguchi's Criteria to the treatment was 22.2 days. During the course of developing the disease, fever was found in all patients, skin lesion in 91.9%, arthralgia in 87.1%, sore throat in 66.1%. Laboratory and imaging tests demonstrated liver enzyme elevation in 82.2%, white blood cell count (WBC) increase in 80.6%, lymphadenopathy\/splenomegaly in 72.6%, negative RF and ANA in 56.5%, ferritin elevation in 82.3%. Laboratory tests before treatment demonstrated that the mean WBC count 15272.3\/\u03bcL, AST 101.8\u2009U\/L, CRP 15.1\u2009mg\/dl, and ferritin 10103.1\u2009ng\/ml. Patients who presented with sore throat as the first symptom fulfilled Yamaguchi's Criteria in 13.6 days after the onset, which was shorter than patients with any other symptoms (fever, 24.0 days; arthralgia, 45.7 days; skin lesion, 31.5 days). Before treatment, patients with sore throat as the first symptom showed highest AST of 139.6\u2009U\/L (fever, 95.3\u2009U\/L; arthralgia, 100.7\u2009U\/L; skin lesion, 71.6\u2009U\/L) and highest ferritin of 19791.8\u2009ng\/ml (fever, 9508.2\u2009ng\/ml; arthralgia, 13071.5\u2009ng\/ml; skin lesion, 8438.1\u2009ng\/ml). However, the duration from the Yamaguchi's Criteria fulfilment to treatment initiation in patients with sore throat as the first symptom was 38.5 days, which was no less than that in patients with the other symptoms (fever, 15.4 days; arthralgia, 31.0 days; skin lesion, 27.0 days). Conclusions Although symptoms of AOSD developed rapidly with symptoms of sore throat, fever, liver enzyme elevation and ferritin elevation, the diagnosis was frequently delayed. Our study suggests that the delayed diagnosis can be attributed in part to non-assumption of the disease. Paying attention to the combination of these symptoms can lead to an earlier diagnosis. Disclosure of Interest None declared","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":220040231,"openaccessinfo":{"externalids":{"MAG":"2910594558","ACL":null,"DOI":"10.1136\/annrheumdis-2018-eular.3376","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ard.bmj.com\/content\/annrheumdis\/77\/Suppl_2\/1743.3.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Plant-growth-promoting bacteria (PGPB) help plants thrive in polluted environments and increase crops yield using fewer inputs. Therefore, the design of tailored biofertilizers is of the utmost importance. The purpose of this work was to test two different bacterial synthetic communities (SynComs) from the microbiome of Mesembryanthemum crystallinum, a moderate halophyte with cosmetic, pharmaceutical, and nutraceutical applications. The SynComs were composed of specific metal-resistant plant-growth-promoting rhizobacteria and endophytes. In addition, the possibility of modulating the accumulation of nutraceutical substances by the synergetic effect of metal stress and inoculation with selected bacteria was tested. One of the SynComs was isolated on standard tryptone soy agar (TSA), whereas the other was isolated following a culturomics approach. For that, a culture medium based on M. crystallinum biomass, called Mesem Agar (MA), was elaborated. Bacteria of three compartments (rhizosphere soil, root endophytes, and shoot endophytes) were isolated on standard TSA and MA media, stablishing two independent collections. All bacteria were tested for PGP properties, secreted enzymatic activities, and resistance towards As, Cd, Cu, and Zn. The three best bacteria from each collection were selected in order to produce two different consortiums (denominated TSA- and MA-SynComs, respectively), whose effect on plant growth and physiology, metal accumulation, and metabolomics was evaluated. Both SynComs, particularly MA, improved plant growth and physiological parameters under stress by a mixture of As, Cd, Cu, and Zn. Regarding metal accumulation, the concentrations of all metals\/metalloids in plant tissues were below the threshold for plant metal toxicity, indicating that this plant is able to thrive in polluted soils when assisted by metal\/metalloid-resistant SynComs and could be safely used for pharmaceutical purposes. Initial metabolomics analyses depict changes in plant metabolome upon exposure to metal stress and inoculation, suggesting the possibility of modulating the concentration of high-value metabolites. In addition, the usefulness of both SynComs was tested in a crop plant, namely Medicago sativa (alfalfa). The results demonstrate the effectiveness of these biofertilizers in alfalfa, improving plant growth, physiology, and metal accumulation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":258072844,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijms24087003","PubMedCentral":"10138511","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/7003\/pdf?version=1681122987","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Operating far-infrared remote-sensing instruments from inside a pressurized cabin of an aircraft requires a window with high transmittance. Furthermore, the radiometric properties of the window, such as the transmittance and the emitted radiation (i.e., temperature distribution), have to be known. The design of a wedged, antireflection coated single-crystal silicon aircraft window, its modeled transmittance spectrum, and the applied coating technique are presented. Measurements of the window transmittance with the 2.5 THz heterodyne spectrometer TeraHertz OH-Measurement Airborne Sounder (THOMAS) and a Fourier-transform spectrometer are presented, showing a transmittance of about 90% around 84 cm\/sup -1\/. The window was designed and built for the 2.5 THz OH-Sensor THOMAS, operated on the DLR research aircraft FALCON. The transmittance of 90% means a substantial improvement compared to the window used previously. With this new window, systematic errors in the measured atmospheric radiance could be lowered, making the retrieval of atmospheric parameters easier. Several successful flights with the new window up to an altitude of 43000 ft have already been performed.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":3}},"corpusid":33621302,"openaccessinfo":{"externalids":{"MAG":"2137753522","ACL":null,"DOI":"10.1109\/36.774710","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Previous work from this laboratory has reported on the effects of two sequential 5 day periods of fasting and subsequent refeeding on tumor promotion in multistage hepatocarcinogenesis in the rat (Carcinogenesis, 18, 159-166, 1997). In the present extension of the earlier study, the sequential fasting-refeeding regimen was begun at later time points (28 and 54 days post-initiation) than the first study. This was done to determine whether larger-sized altered hepatic foci (AHF) exhibited a depletion similar to that of the relatively small AHF in the published experiment and to study concomitant molecular changes during the fasting periods. Groups of animals were fasted in the presence and absence of 0.05% phenobarbital (PB) in the drinking water. During the fasting periods, both body and liver weights decreased dramatically, less in the fast begun at 54 days. This change was accompanied by a significant decrease in the bromodeoxyuridine (BrdU) labeling indices of hepatocytes within AHF. Apoptotic bodies increased dramatically in the non-focal (surrounding the AHF) hepatocytes during the fasting periods. These parameters were slightly lower in hepatocytes of rats administered PB during the fasting periods, most notably during the 54-66 day period. With the nick end-labeling method, the proportion of hepatocytes undergoing apoptosis was significantly higher in cells within AHF at the end of each of the fasting periods in all but one group. Concomitantly, the number of AHF and percentage of liver volume occupied by AHF decreased dramatically during the fasting periods. Refeeding caused a marked increase in BrdU labeling in hepatocytes within and surrounding AHF during the first week or two, most notably in animals not receiving PB during the fasting period. Both the number and volume percentage of liver AHF returned to control values within approximately 2 weeks of the refeeding regimen. Assays of nuclear DNA fragmentation with samples of whole liver indicated that a 'laddering' effect was most noticeable in livers of animals subjected to the fasting-refeeding regimen when phenobarbital was not present during the fasting period. Studies of the levels of mRNA of several genes in the total liver revealed that the expression of c-myc increased 3- to 9-fold during the fasting periods but rapidly returned to normal levels after refeeding. Levels of albumin and insulin-like growth factor I mRNAs decreased significantly during the fasting period, but rapidly reappeared on refeeding. These results indicate that the extensive loss of AHF during the short-term fasting periods occurs even when the number and volume of AHF are 10- to 50-fold greater at the beginning of the fast than the values published previously. Both the decrease in insulin growth factor I and the elevation of c-myc expression during the fasting period may indicate the role of these genes in the transcriptional regulation of hepatocyte apoptosis in both normal and preneoplastic hepatocytes in the rat.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12554717,"openaccessinfo":{"externalids":{"MAG":"2097976840","ACL":null,"DOI":"10.1093\/CARCIN\/19.8.1417","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This proposal will analyse the motivations that led intellectuals of the third century B.C. to create the canon of Wonders of the World. It is emblematic that the ancient sources do not speak of the Wonders of one civilisation or another; they speak of the Wonders of the World, making this one of the first examples of interculturality in which the protagonist is Man side by side with his History. In the contemporary world, where reference is made to belong to a common reality gravitating around the Mediterranean, we look for a \"global\" culture made of images that can express an idea of universality. The wonders of the world could be the key to recomposing under the common denominator of a glorious past, a fragmented reality, such as the Mediterranean one.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":255586639,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.51596\/sjp2020.hodz3157","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The increasing international acceptance of the term \u203abuilding research\u2039 dates back to 1924. The basic approach of understanding historical buildings through building surveys and precise observations is older. To this day, the core of the method has remained working directly on the object in question: the building itself is the main source, regardless of the period and epoch. The graphic representation of the inventory and the scientific results on building history, building techniques and reconstruction play a key role. This small subject has proven itself in many fields, from university research to the preservation of historical monuments, but is currently facing great challenges. The rapid development of new technologies and innovative partner subjects demands a review of methods, including questions of future publication types and languages. New fields of activity are opening up: architecture after 1945 and the increasing destruction caused by war. The educational situation at the universities is becoming more and more uncertain.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":2}},"corpusid":253802888,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1515\/atc-2020-1007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BackgroundThis work increases the ethnomedicinal plants information in the Uvira Territory and, in particular, the middle plateau. Till now little is known about ethnomedicinal researches in Uvira Territory and no previous study has surveyed the medicinal uses of plants in the middle plateau of Uvira Territory. MethodsThe plant uses information survey was collected through a direct interview conducted with 25 local healers in 7 villages. The ethnobotanical information for each species, including scientific name, family, local name, morphological type, plant parts used, preparation, disease name, plant habitat was collected. The conservation status of plant species was checked by the International Union for Conservation of Nature. various quantitative indices (Relative frequency of citation Use Value, Informant consensus factor, Family Importance Value, Pearson's correlation, Jaccard Index) were calculatedResultsInformation on 69 medicinal plants belonging to 61 genera and 34 families was collected. The total number of species per family showed that Fabaceae, Asteraceae, and Myrtaceae were most represented. Most species were herbs. Leave was the most frequently used part and decoction was the principal preparation method. Significantly higher numbers of medicinal plants were used against digestive system disorders and intestinal parasites. Tetradenia riparia, Syzygium guineense, Morella salicifolia and Erythrina abyssinica were the medicinal plants with the highest UV values. The Pearson correlation coefficient between RFC and UV was 0.95 showing a highly positive significant association. A total of 14 species were recorded as vulnerable.ConclusionThis study was able to show that this area, located in middle plateau of Uvira Territory, can provide a considerable medicinal plant diversity with an heterogenous medicinal importance to the community. With the relative high number of vulnerable species, there is a requirement for a sustainable management for these medicinal plants.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":243669496,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-291478\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-291478\/v1.pdf?c=1631873544000","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Purpose To identify whether advanced cancer patients receiving home hospice care and their primary caregivers view artificial hydration (AH) as food or medicine, and the demographic and clinical factors influencing these perceptions. Methods Participants were enrolled in a randomised, double-blind controlled trial examining the efficacy of AH in cancer hospice patients. In-depth interviews at days 1 and 4 of study enrolment explored the meanings attributed to AH at the end of life. Responses to the question, 'Are these fluids more like food or more like medicine?' were categorised as 'food', 'medicine', 'both' or 'other'. \u03c72 analyses were conducted with data from 122 interviews (54 patients and 68 caregivers) to identify differences between patients and caregivers, and by gender, age, ethnicity and caregiver relationship. Predictors of perceptions were identified using logistic regression analysis. Results Overall, 47 participants (38%) understood the fluids to be more like food, 41 (34%) as medicine, 17 (14%) as both, and 17 (14%) as 'other'. Ethnic minority participants (n=34, 66%) were significantly more likely than non-Hispanic European Americans (n=30, 42%) to view AH as food, or both as food and medicine (p=0.034). Ethnic differences persisted in the final regression model (OR 2.7; 95% CI 1.3 to 5.7, p=0.010). No significant differences were detected between patients and caregivers, or across gender, age, caregivers' relationship to the patients, group assignment, disease severity or cancer type. Conclusions AH was perceived as food\/nutrition by many cancer patients and caregivers in the study, particularly among ethnic minorities. This perception may lead to greater distress if fluids are discontinued or withheld. Asking patients\/caregivers about their AH perceptions may enhance patient\/provider communication and culturally appropriate end-of-life care.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":206922559,"openaccessinfo":{"externalids":{"MAG":"2034168428","ACL":null,"DOI":"10.1136\/bmjspcare-2012-000205","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3962949?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Contact with hydrofluoric acid may produce extensive tissue necrosis. This can be prevented by prompt recognition and specific treatment. Unfortunately, symptoms and therefore treatment are often delayed. Education of employees and physicians should result in the prevention of unnecessary tissue destruction and pain for those inadvertently exposed to hydrofluoric acid.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59258157,"openaccessinfo":{"externalids":{"MAG":"2417099194","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The well-known pebbles finding places are situated around Stranice, north of Celje. They consist of alveolina-nummulites limestone in the Lower Miocene clastite. A new finding place was discovered and the following species were established: Assilina plana, Nummulites aquitanicus and N. partschi , which indicate the Lower Cuisian limestone.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249648521,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gene transfer technology changes some of the characteristics of crops. However, genetically modified foods have been reported to have an impact on human health. We proposed a cost effective and highly sensitive biosensor electrode with self-assembled monolayer of gold nanoparticle on a micro hemisphere array to detect genetically modified soybean. An ordered array of micro hemispherical features was formed on a 6-inch reclaimed silicon wafer using photolithography. Then, a thin gold layer was sputtered onto the hemispheres. The wafer was then immersed into a 5 mM ethanol solution of 1,6-hexanedithiol (1,6-HDT) to enable the attachment of one thio-end of 1,6-HDT to the thin gold layer. Next, a colloidal gold (15 nm) solution was dripped onto the wafer and baked on a hot plate in such a way that the monolayer of gold nanoparticles could self-assemble on the 1,6-HDT surface. Finally, we used electrochemical impedance spectroscopy (EIS) analysis to detect genetically modified soybean. Experimental results demonstrate that our biosensor can successfully distinguish the genetically modified soybeans from the normal ones.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":213652366,"openaccessinfo":{"externalids":{"MAG":"2989608089","ACL":null,"DOI":"10.1115\/detc2019-97112","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the field of autonomous robotics, manipulation planning is a problem of major significance. A very important component within a manipulation planner is a path planner that is able to connect two configurations by a feasible continuous path, provided that such a path exists. Recently, a new probabilistic path planning method, probabilistic cell decomposition (PCD), has been shown to perform well for, amongst other problems, motion planning for a robotic manipulator. In this paper we investigate how the performance of the general method can be further improved when used within the context of manipulation planning by incorporating knowledge of a specific manipulator. We propose pre-computation of a cell decomposition covering self-collision, adjustment of the cell splitting procedure to the articulated structure of the robot and tuning of distance metrics with respect to the robot. To evaluate the algorithms, we present simulations of a Puma 560 robot arm mounted on a Nomadic XR4000 mobile platform.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":14476378,"openaccessinfo":{"externalids":{"MAG":"2097965677","ACL":null,"DOI":"10.1109\/IROS.2004.1389834","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Emotion is a complicated psychological activity. Psychologists hold that emotion is the remnants of animals' origins. In fact, human emotion is not only a kind of sign of animals' origins, but it is also greatly influenced by social and cultural factors. Psychologists have also classified emotion into advanced and lower ranks. Emotion induced by social and cultural factors is considered advanced, and is unique to human beings. In recent years, more cities have tended to demonstrate their cultural values in public environments and facilities, among which street furniture play a crucial role. Researchers and practicing designers have also considered how different emotions relate to the production and reception of street furniture design. Therefore, besides its basic physical function, a considerable number of street furniture is also designed to catch the public's eye and serve to be important windows to illustrate different cultural values. This paper first explores feelings and emotional experiences induced by cultural elements. By using the findings of a survey, this paper compares the effect of different cultures on the emotional experience towards the same street furniture. Taking Hong Kong and Beijing as case studies, several kinds of typical street furniture are analysed and the relevant distinct feelings aroused by street furniture of people from different cultural backgrounds are examined. This paper holds that different cultural factors can arouse users' different emotions such as hate, love, joy, sorrow and so on even when the users use the same street furniture.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":250075552,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Unikernels are minimal, single-purpose virtual machines. This new operating system model promises numerous benefits within many application domains in terms of lightweightness, performance, and security. Although the isolation between unikernels is generally recognized as strong, there is no isolation within a unikernel itself. This is due to the use of a single, unprotected address space, a basic principle of unikernels that provide their lightweightness and performance benefits. In this paper, we propose a new design that brings memory isolation inside a unikernel instance while keeping a single address space. We leverage Intel's Memory Protection Key to do so without impacting the lightweightness and performance benefits of unikernels. We implement our isolation scheme within an existing unikernel written in Rust and use it to provide isolation between trusted and untrusted components: we isolate (1) safe kernel code from unsafe kernel code and (2) kernel code from user code. Evaluation shows that our system provides such isolation with very low performance overhead. Notably, the unikernel with our isolation exhibits only 0.6% slowdown on a set of macro-benchmarks.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":211828465,"openaccessinfo":{"externalids":{"MAG":"3009731533","ACL":null,"DOI":"10.1145\/3381052.3381326","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Persian walnut, Juglans regia L., is a long-lived, wind-pollinated and deciduous tree, which produces large, woody, shelled and edible nuts. J. regia is one of the most economically important cultivated species for timber and nutritious nuts. Its nuts have medicinal importance for human health by high antioxidant capacity. J. regia has been planted in Northern Vietnam for decades. In this study, a survey was conducted in three provinces to understand current planting sites and production of planted trees. The results indicated that J. regia was planted personally in gardens of local people in Lai Chau, Lao Cai and Ha Giang provinces, sharing borderlines with China. The planted trees are 10-30 years old with some exceptions of up to 40-50 years old. Generally, each household owns 2-3 fruited trees with some exceptions of up to 10 trees. After planting 7 years, trees fruit annually. However, the production varies among trees. A best 20-25-year-old tree can yield 55 kg fruits\/year with current market price of 1.5 US$\/ 1 kg fruits. There exists high variation of fruit production among planted sites, as results of climate difference, and unknown source and sexual propagation seedlings. It is concluded that to establish an extensive plantation of J. regia for high fruit production, selecting superior genotypes from local populations should be conducted, then vegetative propagation such as grafting should be applied to produce good and uniform seedlings.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":200028404,"openaccessinfo":{"externalids":{"MAG":"2963988043","ACL":null,"DOI":"10.9734\/AJARR\/2019\/V5I130123","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mutation analysis is an effective, yet often time-consuming and difficult-to-use method for the evaluation of testing strategies. In response to these and other challenges, this paper presents MAJOR, a fault seeding and mutation analysis tool that is integrated into the Java Standard Edition compiler as a non-invasive enhancement for use in any Java-based development environment. MAJOR reduces the mutant generation time and enables efficient mutation analysis. It has already been successfully applied to large applications with up to 373,000 lines of code and 406,000 mutants. Moreover, MAJOR's domain specific language for specifying and adapting mutation operators also makes it extensible. Due to its ease-of-use, efficiency, and extensibility, MAJOR is an ideal platform for the study and application of mutation analysis.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2014-10":1,"2015-18":1}},"corpusid":9168062,"openaccessinfo":{"externalids":{"MAG":"2028990673","ACL":null,"DOI":"10.1109\/ASE.2011.6100138","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract 3195 Poster Board III-132 Background Aplastic Anemia (AA) is characterized by an acquired, progressive loss of hematopoietic tissue from the bone marrow thought to result from an immune reaction targeting the stem cell. Lymphocytes expressing CD8 and cytokines, including tumor necrosis factor alpha and interferon gamma, are known key factors in the pathophysiology. More recently, the role of other T cell populations has been invoked. We undertook the current retrospective study of 19 consecutive pediatric patients to understand the scope of immune dysregulation seen in children with AA. Patients between the ages of 2 and 17 (10 girls, 9 boys) were referred to our center for evaluation of pancytopenia and underwent a staged comprehensive work up to exclude heritable, infectious, infiltrative, or nutritional etiologies for bone marrow failure. Patients were categorized as severe (n=16), or moderately severe (n=3) according to accepted criteria. Association with hepatitis was noted in one patient. Laboratory studies were performed in a certified clinical laboratory, with reference ranges established according to established protocols. Methods In a subset of 9 patients, we performed detailed T- cell immunophenotyping by flow cytometry. As previously described in adult AA patients, 5 of our 9 patients showed decreases in CD56\/CD16 co-expressing NK cells (% range: 1.9-7.5% with reference range of 5-15%) whereas CD2 \/CD25 co-expressing T-regulatory cells were decreased in 1 of 9 patients and increased 3 of 9 patient without correlation with demographic, or clinical parameters (% range: 0.6-15.3% with reference range of 2-10%). Further detailed analysis of T-cell subsets revealed an increase in CD3\/CD4 double-negative T-cells (DNT) in 6 of 9 patients (% range: 2.3-21.7% with reference range of 0-4%). This population is widely considered diagnostic of autoimmune lymphoproliferative syndrome (ALPS), a rare immune mediated disease commonly involving lymphadenopathy, splenomegaly, fevers and variable cytopenias. While ALPS often arises from mutations in components of fas apoptotic signaling pathway, none of the nine patients tested showed abnormalities outside the reference range in cell surface expression of fas -, or fas ligand. Finally, clones of cells lacking expression of glycosylphosphatidyl-inositol (GPI) linked proteins have been reported in adult patients with AA, where clone size fluctuates with response to immunotherapy treatment. Among our patients 4 of 9 showed red cell (% clonal size range 0.1-14.6) or white blood cell (% clonal size range 0.2-38) clones. Conclusion In conclusion, our study in a pediatric AA cohort, while small, confirms key findings of immune dysregulation previously seen in adult patients and for the first time demonstrates the existence of sizable populations of immature double-negative T-cells. Understanding the full spectrum of immune dysfunction is critical in understanding the pathophysiology of AA and may help in guiding immunotherapy. Disclosures No relevant conflicts of interest to declare.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79135516,"openaccessinfo":{"externalids":{"MAG":"2582607825","ACL":null,"DOI":"10.1182\/BLOOD.V114.22.3195.3195","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An application of the R2TR method (1995, Chem. Phys. Lett. 232, 424) to selective homonuclear polarization transfer under magic angle spinning is proposed. It is shown that, for a spinning speed fast enough to remove the maximum homonuclear dipolar coupling constant omegaD involved, the flip-flop and flop-flop mechanisms are suitable for recoupling the spins with a chemical shift difference larger than omegaD and a difference comparable to or smaller than omegaD, respectively. It is also shown that, for fast polarization transfer, the off-resonance frequencies should be much higher than the RF intensity in the flip-flop condition, while for the flop-flop condition, the off-resonance frequencies should be much lower than the RF intensity. Some one- and two-dimensional experiments are proposed by utilizing the capability of the R2TR method to abruptly switch on and off the recoupling condition, and are demonstrated for triply 13C-enriched l-alanine. The mixing time required for population transfer was found to be ca. 0.5 ms for the methine and methyl 13C spins separated by 1.5 A and ca. 5 ms for the methyl and the carboxyl carbons separated by 2.5 A. The experimental results and theoretical simulations show that selective polarization transfer is achieved when the difference in the isotropic chemical shifts between the relevant pair of spins and a neighboring spin is more than 1000 Hz.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40663325,"openaccessinfo":{"externalids":{"MAG":"1983392735","ACL":null,"DOI":"10.1006\/JMRE.1997.1191","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We used skin-grafting to assess the genetic variability between 2 populations of the parthenogenetic lizard Aspidoscelis cozumela. We transplanted 238 skin fragments among individuals of 2 coastal populations at Cozumel Island. Grafts belonging to individuals that survive more than 60 days suggested genetic homogeneity between both populations, consistent with the existence of only 1 clone within this unisexual species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207841446,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper explores the factors that determine firm's RD and in the second stage the factors that affect the choice of partners. And third, we apply an ordered probit model to test the marginal effects of explanatory variables on the different partners. Here we contrast some of the most interesting empirical hypotheses of previous studies, and which emphasize the role of employees with degrees and PhDs in facilitating cooperative R&D between firms and scientific partners.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":115969286,"openaccessinfo":{"externalids":{"MAG":"2729790686","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we describe the design of prototypes of histogram-based visualizations for browsing large, timedependent collections of data. These visualizations are intended to provide an alternative to the standard hierarchical file browsing metaphor currently available, and are used to expose time-related information from the underlying dataset that would not be apparent using standard file browsers. The visualizations are also designed to provide a method of browsing that does not require knowledge of the underlying file storage architecture, as well as to be able to scale to large data stores. Two prototype visualizations are designed and presented to a small group of users to determine if the histogram-based metaphor for file browsing and visualization of large data collections is intuitive and usable.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59656477,"openaccessinfo":{"externalids":{"MAG":"69611101","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 5-month-old Warmblood cross colt was presented with focal swelling of the ventral abdomen extending from the umbilicus to the scrotum in the absence of colic signs. Palpation and ultrasound examination revealed the presence of incarcerated large intestine within the subcutaneous space adjacent to the caudal ventral abdomen and prepuce. Surgery was performed and revealed that the umbilical hernia sac had ruptured, and confirmed that the left dorsal and ventral colon were present in the subcutaneous space. The mild degree of vascular compromise of the large colon did not necessitate resection and so it was replaced within the abdomen. The abdominal wall defect was closed and the subcutaneous dead space was reduced by using a walking suture pattern. Herniation of the large colon through the umbilicus with dissection through the subcutaneous tissues of the ventral abdominal wall and prepuce has not been previously reported in foals. Ultrasonography permits differentiation of herniated small intestine from large intestine.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":71016413,"openaccessinfo":{"externalids":{"MAG":"1547632478","ACL":null,"DOI":"10.1111\/EVE.12163","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: To evaluate a scoring system in predicting difficulty in laparoscopic cholecystectomy. Study Design: Non-Randomized Prospective study. Setting: Surgical Unit-1 of Holy Family Hospital, Rawalpindi. Period: January 2018 to September 2018. Material & Methods: Patients with symptomatic gallstone disease that were admitted in SU-1 of Holy family hospital during the above period were included in the study. For collection of data, a pre-tested questionnaire was used after taking informed oral consent. On admission, one day before the surgery, preoperative points were allotted on basis of patient's history, examination, hematological (CBC), biochemical (LFTs) and ultrasound results. Preoperative scores up to 5 was summed up as easy, scores 6 \u2013 10 as difficult, 11 \u2013 16 as very difficult. Calculated sample size was 229. SPSS version 22 and WHO Anthro calculator version 3.2.2 were used for data entry and analysis. Results: Among 230 patients that were included in the study, 188 were female and 42 were male. Various risk factors were found to have significant positive correlation with intraoperative difficulty during cholecystectomy. These are: Previous episodes of cholecystitis and pancreatitis (p=0.00), ERCP (p=0.00), tenderness in right hypochondrium (p=0.002), hepatitis serology (p=0.02), and Total Leukocyte Count (p=0.006). Whereas the following factors had insignificant relation with intraoperative difficult cholecystectomy: ALT and ALP (p>0.05, p=0.06 and 0.26 respectively) and hepatits serology (p=0.406). A significant correlation was found between preoperative and intraoperative scores of the patients (p=0.003) indicating that preoperative assessment of various risk factors can predict the level of difficulty of cholecystectomy and its conversion to open cholecystectomy. Conclusion: We may conclude that the scoring system evaluated in our study is a sturdy, reliable and useful benchmark to predict difficult cases. Preoperative prediction of the risk factors of conversion or difficulty of operation is an important point for operative planning and the high-risk patients may be informed accordingly.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":249296366,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.29309\/tpmj\/2022.29.06.4674","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/theprofesional.com\/index.php\/tpmj\/article\/download\/4674\/4878","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Three studies investigated a boundary condition on the illusion-of-control effect (the tendency to behave as if one can control random events). Subjects wagered poker chips on the roll of a die, either to win money or to reduce the amount of time they would have to spend on unpleasant tasks. To induce illusory control, half of the subjects were allowed to choose the face of the die on which they would bet and were told they would throw the die. In addition, each chip represented either a small or large amount of money or task time. When potential costs were low, subjects with illusory control wagered more and were more confident of winning than were subjects without illusory control. When potential costs were high, illusory control had no effect on wagers or confidence. Preliminary evidence was found for a mood interpretation of these results. The illusion of control increased positive affect in both the low- and high-cost conditions. When costs were low, this positive affect may have been responsible for...","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":261909162,"openaccessinfo":{"externalids":{"MAG":"1964443172","ACL":null,"DOI":"10.1521\/SOCO.1990.8.3.305","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, we investigate the effects of CO2 laser polishing on microscopic structures fabricated by femtosecond laser assisted carving (FLAC). FLAC is the peripheral laser irradiation of 2.5D structures suitable for low repetition rate lasers and is first used to define the microwell structures in fused silica followed by chemical etching. Subsequently, the bottom surface of patterned microwells is irradiated with a pulsed CO2 laser. The surfaces were characterized using an atomic force microscope (AFM) and scanning electron microscope (SEM) in terms of roughness and high quality optical imaging before and after the CO2 laser treatment. The AFM measurements show that the surface roughness improves more than threefold after CO2 laser polishing, which promises good channel quality for applications that require optical imaging. In order to demonstrate the ability of this method to produce low surface roughness systems, we have fabricated a microfluidic channel. The channel is filled with polystyrene bead-laden fluid and imaged with transmission mode microscopy. The high quality optical images prove CO2 laser processing as a practical method to reduce the surface roughness of microfluidic channels fabricated by femtosecond laser irradiation. We further compared the traditional and laser-based glass micromachining approaches, which includes FLAC followed by the CO2 polishing technique.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":43989387,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":", 1403 (2009); 326 Science et al. Kim F. Rewitz Torso to Initiate Metamorphosis The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): July 12, 2014 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http:\/\/www.sciencemag.org\/content\/326\/5958\/1403.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http:\/\/www.sciencemag.org\/content\/suppl\/2009\/12\/03\/326.5958.1403.DC1.html can be found at: Supporting Online Material http:\/\/www.sciencemag.org\/content\/326\/5958\/1403.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http:\/\/www.sciencemag.org\/content\/326\/5958\/1403.full.html#ref-list-1 , 4 of which can be accessed free: cites 19 articles This article http:\/\/www.sciencemag.org\/content\/326\/5958\/1403.full.html#related-urls 15 articles hosted by HighWire Press; see: cited by This article has been http:\/\/www.sciencemag.org\/cgi\/collection\/development Development subject collections: This article appears in the following","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207770808,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The first interim report on the Eisenhower State Curriculum Frameworks Projects examines the progress grantee states have made in completing mathematics and science curriculum frameworks and developing new approaches to teacher education, certification, recertification, and professional development. In addition, the report describes many of the issues confronting states as the projects move toward completion. The projects have made good progress on the development of curriculum frameworks, completing 22 of the 28 frameworks proposed across 16 states. The projects have established similar vision statements that call for all students to meet high standards in mathematics and science and are developing curriculum frameworks designed to serve as a bridge between national standards and local educators. Having devoted most of their time and resources to the development of curriculum frameworks, the vast majority of projects have not made much progress on the development of model guidelines for teacher education and certification, criteria for teacher rectification, and model professional development programs. Even among those projects that have made progress on the other products, they do not share a clear consensus of definition, purpose, and audience. A preliminary report finding is that aligning education policies, especially assessment systems, with curriculum frameworks is likely to be a slow process. (Author\/MKR) ********************************************* Reproductions supplied by EDRS are the best that can be made from the original document. * * *********************************************************************** Evaluation of the Dwight D. Eisenhower Mathematics and Science State Curriculum Frameworks Projects: First Interim Report","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":207841440,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The recently reevaluated high prevalence of healthy carriers (1\/2,000 in UK) of variant Creutzfeldt-Jakob Disease (v-CJD), whose blood might be infectious, suggests that the evolution of this prion disease might not be under full control as expected. After experimental transfusion of macaques and conventional mice with blood derived from v-CJD exposed (human and animal) individuals, we confirmed in these both models the transmissibility of v-CJD, but we also observed unexpected neurological syndromes transmissible by transfusion: despite their prion etiology confirmed through transmission experiments, these original cases would escape classical prion diagnosis, notably in the absence of detectable abnormal PrP with current techniques. It is noteworthy that macaques developed an original, yet undescribed myelopathic syndrome associating demyelination and pseudo-necrotic lesions of spinal cord, brainstem and optical tract without affecting encephalon, which is rather evocative of spinal cord disease than prion disease in human medicine. These observations strongly suggest that the spectrum of human prion diseases may extend the current field restricted to the phenotypes associated to protease-resistant PrP, and may notably include spinal cord diseases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":51928585,"openaccessinfo":{"externalids":{"MAG":"2887988214","ACL":null,"DOI":"10.1080\/19336896.2018.1505399","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/19336896.2018.1505399?needAccess=true","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The response of a rigid cylinder embedded in a homogeneous, isotropic half space to a step function incident stress wave is investigated. The boundary integral equation method is used directly in the time domain where two types of interfacial stresses are considered: In the first case, the interfacial stresses are not permitted to exceed a prescribed constant maximum value (elastic\u2010perfectly plastic interface behaviour); in the second case, a friction interface is considered where the limiting stresses vary along the interface according to the normal interfacial pressure. The angular distribution of shear stress at different times are examined to illustrate the redistribution of interfacial stresses. The relative displacements between the cylinder and half space are also presented.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":122445727,"openaccessinfo":{"externalids":{"MAG":"2091866026","ACL":null,"DOI":"10.1061\/(ASCE)0733-9399(1987)113:10(1565)","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Babylonian Talmud provides a series of stories about a certain \u1e24anina ben Dosa, the last of the so-called men of deed according to the Mishna. This \u1e24anina ben Dosa appears only sparsely in the earlier Palestinian rabbinic works. It seems therefore that the later, more elaborate, and more numerous stories about this character in the Babylonian Talmud represent a case of fan fiction. Using the distinction between canon and fanon, as is common in fan fiction communities, I reconstruct the conventions applied by the canon (Mishna and Tosefta) to the character \u1e24anina ben Dosa, as well as the expanded conventions accepted by the fannish community (or interpretive community) represented by the Babylonian Talmud. The fanon used in a story cycle will be tested against an isolated \u1e24anina ben Dosa story in a different Talmudic tractate as well as against an extra-Talmudic story. The applied conventions with regard to \u1e24anina ben Dosa as adopted in an\u00a0historiola\u00a0of an incantation on an Aramaic amulet bowl from Mesopotamia will eventually appear to be the same as those of the Talmud.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":214301222,"openaccessinfo":{"externalids":{"MAG":"2995144515","ACL":null,"DOI":"10.3983\/twc.2019.1647","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3983\/twc.2019.1647","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo determine the pathologic risk factors after nephroureterectomy in patients with urothelial carcinoma of the renal pelvis and ureter.\n\n\nPATIENTS AND METHODS\nWe investigated the clinicopathological features of 131 patients (94 males and 37 females) with urothelial carcinoma of the renal pelvis and ureter who underwent nephroureterectomy at our department and related facilities from August, 1994 to August, 1997. The mean age of the patients was 68 years, ranging from 24 to 86 years.\n\n\nRESULTS\nThe 1-, 3- and 5-year cause-specific survival rates (Kaplan-Meier's method) for all of the patients were 91.8%, 76.7%, and 67.8%, respectively. The significant prognostic factors for survival rates by univariate analysis using the log rank test were tumor stage, infiltration pattern, lymphatic invasion, vessel invasion and lymph node metastasis. On the other hand, multivariate analysis using Cox proportional hazards regression model showed the most influential prognostic factors to be vessel invasion and tumor stage.\n\n\nCONCLUSIONS\nFrom these results, in urothelial carcinoma of the renal pelvis and ureter underwent nephroureterectomy, we suggested that vessel invasion and tumor stage were the independent prognostic factors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35301084,"openaccessinfo":{"externalids":{"MAG":"2318826580","ACL":null,"DOI":"10.5980\/JPNJUROL1989.97.786","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Genomic research are currently of key importance in the development of medicine. In order to carry out such activities, it is necessary not only to generate new genetic objects, but also to accumulate samples in the form of various biomaterials. Such collections in recent years are the pride of large biobanks, which spend the maximum amount of effort to save samples for subsequent research or application in practice. However, the functioning of biobanks has another side of the coin: the accumulation of certain information entails an increased level of responsibility for the collected data. In modern Russian conditions, the issues of information leakage from such institutions taking place in foreign countries are still irrelevant. In many ways, the reason for this is only the beginning of the normative legal regulation of the relevant social relations, which are only beginning to appear on the territory of our state. Therefore, there is every reason to believe that such problems will arise and it is important to solve them. Some proposals for such activities are set out in this paper.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":241187081,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17803\/1729-5920.2019.151.6.153-160","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/lexrussica.msal.ru\/jour\/article\/download\/811\/738","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"In the present investigation, the changes in precipitation of the shellac condensates with curing time have been followed turbidimetrically. The experimental data support the saturation limit law. Further, the fractionation of a polymer with low degree of polymerization has been effected by the integral method, and the relation between Wx (the weight fraction of the precipitate) and v (the volume of precipitant added) has been established. In addition, the fractions have been characterized in terms of inherent viscosity. The experimental data, which exhibit alternation behavior, have been confirmed by a number of statistical tests.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":95750312,"openaccessinfo":{"externalids":{"MAG":"2008124886","ACL":null,"DOI":"10.1002\/app.1977.070211011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Housing equity is the principle asset of a large fraction of older Americans. Indeed many retired persons have essentially no financial assets, other then Social Security and, for some, employer-provided pension benefits. Yet we find that housing wealth is typically not used to support non-housing consumption during retirement. Based on data from the Survey of Income and Program Participation, and the Asset and Health Dynamics Among the Oldest Old, we consider the change in home equity as families age. The results are based in large part on families aged 70 and older. We find that, barring changes in household structure, most elderly families are unlikely to move. Even among movers, those families that continue to own typically do not reduce home equity. However, precipitating shocks, like the death of a spouse or entry to a nursing home, sometimes lead to liquidation of home equity. Home equity is typically not liquidated to support general non-housing consumption needs. The implication is that when considering whether families have saved enough to maintain their pre-retirement standard of living after retirement, housing equity should not be counted on to support general non-housing consumption. These conclusions seem to correspond closely with the results of a recent American Association of Retired Persons survey, which found that 95 percent of persons 75 and older agreed with the statement: What I'd really like to do is stay in my current residence as long as possible.'","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":153090729,"openaccessinfo":{"externalids":{"MAG":"1544805571","ACL":null,"DOI":"10.3386\/W7882","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Oral DVT prophylaxis not requiring monitoring is an advantage in orthopaedic patients. Dabigatran etexilate is an oral direct thrombin inhibitor undergoing evaluation for the prevention of venous thromboembolic events (VTE) following orthopaedic surgery. METHODS: In a phase III, multicenter, non-inferiority, double-blind study, patients undergoing total knee replacement were randomized to 3 treatments. The patients received 8\u00b12 days of oral dabigatran etexilate, 150 or 220 mg once daily starting with a half dose (i.e.75 or 110 mg) 1\u20134 hours after surgery, or subcutaneous enoxaparin 40 mg once daily starting 12 hours prior to surgery. The primary efficacy outcome was the composite of total VTE and all causes of mortality during the treatment period. All efficacy and safety outcome events were adjudicated by blinded independent committees. RESULTS: Efficacy could be evaluated for 1541 (75%) treated and operated patients. Total VTE and death occurred in 40.5%, 36.4% and 37.7% of patients assigned to dabigatran etexilate 150 or 220mg once daily or enoxaparin, respectively. Proximal DVT and\/or PE occurred in 3.8%, 2.6% and 3.5% of patients receiving dabigatran 150 or 220mg or enoxaparin, respectively. Three deaths occurred during the treatment period, one in each of the treatment groups. Safety was evaluated for all 2076 patients receiving study treatment. The rate of major bleeding was 1.3%, 1.5% and 1.3% of patients receiving dabigatran 150 or 220mg or enoxaparin. Elevated LFTs (ALT >3xULN) occurred in 3.7%, 2.8% and 4.0% of the patients treated with 150 and 220 mg dabigatran or enoxaparin during the study. A late temporary rise in LFTs was observed in 6 patients (0.5%) who had received dabigatran. CONCLUSIONS: Non-inferiority for the primary efficacy endpoint was met for both doses of dabigatran etexilate compared to enoxaparin. There was no difference in bleeding rates between the treatment groups. Oral administration of dabigatran etexilate once daily, given early in the postoperative period, was effective and safe for the prevention of total VTE in patients undergoing total knee replacement surgery.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":78895487,"openaccessinfo":{"externalids":{"MAG":"2592610323","ACL":null,"DOI":"10.1182\/BLOOD.V108.11.573.573","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Give clear concepts about what is quality, what it is the relationship marketing and how the joint work of these two can help achieve the organizational excellence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":169391170,"openaccessinfo":{"externalids":{"MAG":"2793503767","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"NASA is participating in the International Committee on Global Navigation Satellite Systems (GNSS) (ICG)'s efforts towards demonstrating the benefits to the space user in the Space Service Volume (SSV) when a multi-GNSS solution space approach is utilized. The ICG Working Group: Enhancement of GNSS Performance, New Services and Capabilities has started a three phase analysis initiative as an outcome of recommendations at the ICG-10 meeting, in preparation for the ICG-11 meeting. The first phase of that increasing complexity and fidelity analysis initiative is based on a pure geometrically-derived access technique. The first phase of analysis has been completed, and the results are documented in this paper.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":132702224,"openaccessinfo":{"externalids":{"MAG":"2523461058","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo compare proliferation and blood flow in pelvic and thoracic bone marrow 1 year after pelvic chemoradiation.\n\n\nMETHODS\nSixteen pelvic cancer patients were enrolled in an IRB-approved protocol to acquire FLT PET images during radiation therapy simulation (baseline) and 1 year after chemoradiation therapy. Three subjects also had optional O-15 water PET images acquired 1 year after chemoradiation therapy. Baseline FLT PET images were used to create IMRT plans to spare pelvic bone marrow identified as regions with FLT SUV \u2265 2 without compromising PTV coverage or OAR sparing. Marrow VOIs were defined using a 50% maximum pixel value threshold on baseline FLT PET images (VIEW, PMOD version 3.5) in the sacrum and thoracic spine representing irradiated and non-irradiated regions, respectively. FLT PET and O-15 water PET images acquired 1 year after therapy were co-registered to baseline images (FUSION PMOD) and the same VOIs were used to measure proliferation (FLT SUV) and blood flow (O-15 water uptake). Separate image-based input functions were used for blood flow quantitation in each VOI.\n\n\nRESULTS\nMean 1 year FLT SUV in sacral and thoracic VOIs for were 1.1 \u00b1 0.4 and 6.5 \u00b1 1.7, respectively for N = 16 subjects and were 1.2 \u00b1 0.2 and 5.6 \u00b1 1.6, respectively for N = 3 subjects who also underwent O-15 water imaging. Blood flow measures in equivalent sacral and thoracic marrow regions (N = 3) were 21.3 \u00b1 8.7 and 18.3 \u00b1 4.9 mL\/min\/100mL respectively.\n\n\nCONCLUSION\nDecreased bone marrow proliferation measured by FLT SUV does not appear to correspond to decreased blood flow as measured by O-15 water PET imaging. Based on this small sample at a single time point, reduced blood supply does not explain reductions in bone marrow proliferative activity 1 year after chemoradiation therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":10681765,"openaccessinfo":{"externalids":{"MAG":"2460860734","ACL":null,"DOI":"10.1118\/1.4956130","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"While research on children's humour is growing, few investigations have focused on how children use humour in conflict interactions, and specifically in group early childhood settings. Using data extracts from a project that investigated children's naturally occurring conflict interactions in a multi-ethnic early childhood setting, we use interactional sociolinguistics to analyse how children used humour at unexpected moments during conflict situations. The analysis probes different meanings carried in the children's use of humour, illustrating how humour intersected with personal and relational power to resolve or defuse conflict, or to coerce compliance with existing peer relational positions. The analysis broadens understandings of the significance of humour in children's lives in early childhood settings, and particularly in the context of conflict interactions that have a 'stretchy temporality' connecting interactive moves to others in the past, and to existing power positions in peer relationships.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-18":1,"unknown":2}},"corpusid":258075968,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/1476718X231159300","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the research results of the difficulties faced by students and lecturers during their pronunciation teaching and learning in the pronunciation part in the text book New English File Elemantary. The difficulties found are mainly the attractiveness of pronunciation elements and pronunciation units, the level of difficulties of the English pronunciation elements, and the inappropriate use of the learning and teaching activities which need to be suitable with learners' abilities. Basing on the difficulties, some solutions were suggested in the paper in order to improve the pronunciation teaching and learning\u00a0 for non-major students at Tay Bac University.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":203046948,"openaccessinfo":{"externalids":{"MAG":"2972274393","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A survey of the amphibians and reptiles of Reserva Natural Absoluta Cabo Blanco (RNACB), Puntarenas, Costa Rica was conducted from May to August 2003. Thirteen amphibian and 19 reptile species were found within the RNACB boundaries. Twenty-two of these species were not previously recorded from the lower Nicoya Peninsula and for seven, this locality represents the southernmost extension of their range. One additional amphibian and three reptile species are known from the area based on literature review and examination of museum collections. However, interviews with locals indicate that up to nine other reptile species could be present in the reserve. I observed all but one amphibian species at Laguna Balsitas and at least eight species utilize the lagoon for reproduction. The lagoon is also notable for its population of Kinosternon scorpioides. This study will provide a baseline for further research in the reserve.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":88667198,"openaccessinfo":{"externalids":{"MAG":"2507781943","ACL":null,"DOI":"10.15560\/5.3.446","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/checklist.pensoft.net\/article\/17886\/download\/pdf\/","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract This study analyses the adjustment of the Finnish earnings-related pension system to very low economic growth. The results show that a permanently lower growth rate of the wage bill would raise only moderately the pension contribution rates in the long term. This is because also the benefits are partially linked to wages. But if the rate of return on the pension fund investments would also go down, the contribution rates would increase significantly. External competitiveness and employment would weaken as well as the position of future generations. The study presents a pension reform that stabilizes the contribution rate by raising the retirement age and cutting pensions. These kind of specific reforms are not, however, optimal due to demographic and economic uncertainty. A better solution would be automatic adjustment rules that are designed to provide accepted redistribution of income between various generations.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":152597359,"openaccessinfo":{"externalids":{"MAG":"653552269","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim is to study the features of the influence of local ultraviolet radiation on the organization and structure of collagen fibers in the radiation area. The studies were performed on 30 albino guinea pigs weighing 400-500 g, exposed to local ultraviolet radiation. Animals were removed from the experiment after 2 hours, 4 hours, 3 days, 8 days after irradiation. The control group was intact guinea pigs. To assess the structure and location of collagen fibers, skin sections in the irradiated area were studied using histological methods with polarized light analysis of collagen, and they were also analyzed using a scoring system for three parameters: composition, refraction intensity, and orientation of collagen fibers. The revealed structural features of collagen fibers reflect the course of the process of degeneration of the collagen skeleton of the dermis with a violation of the orientation and ordering of collagen fibers and an increase in the content of type III collagen with an increase in the observation period. According to the results of a semi-quantitative assessment of the state of collagen fibers, a significant deterioration in their structure and composition was recorded starting from 4 hours after exposure to ultraviolet radiation and progressed with an increase in the observation period. On the 8th day, the maximum deviation from the structure of the normal dermis is determined by the total number of points. The influence of local ultraviolet radiation in the minimum erythema dose on the skin of guinea pigs leads to the development of disturbances of the organization (abnormal position and ordering) and structure (increase in collagen content of type III) of collagen fibers of the dermis, which progress with an increase of the observation period.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220587134,"openaccessinfo":{"externalids":{"MAG":"3043267921","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work \"iconolatry and the African Christianity: the Nigerian experience\", examines the resurgence of the veneration and otherwise the worship of icons and symbols that shook the foundation of the early church history now in Nigerian Christianity. It could be recalled that iconolatry as the worship of images or icons, was one of the major issues in Christian history that led to the iconoclastic controversy in the 8 th century of Christianity ( c 725 to 787). More so, iconolatry was one of the burning issues in the 16 th century protestant reformation that vehemently criticized the Roman Catholic Church for idolatry. From the historical perspective of the contemporary trend in African Christianity, especially in Nigeria, this work observed that image worship or veneration has taken a center stage in the beliefs and practices of the entire spectrum of faith in Nigerian Christianity, especially the new Christian religious movements here represented by the Pentecostals. This paper is therefore poised to lead the Nigerian church (Christianity) to cast a retrospective look at Christian history to guide against the obvious resurgent of iconolatry for which the church suffered a great deal in history. Key Words : Iconolatry, African Christianity, Pentecostal, Pentecostalism, Catholicism, Idolatry, Nigeria, Iconography","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":212939409,"openaccessinfo":{"externalids":{"MAG":"2990852690","ACL":null,"DOI":"10.4314\/ijah.v8i4.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ajol.info\/index.php\/ijah\/article\/download\/191447\/180613","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"elcome to the 20th International Conference on Advanced Information Networking and Applications (AINA 2006). The conference will be held in Vienna University of Technology, Vienna, Austria. This international conference is a forum for sharing ideas and research work in the emerging areas of information networking and their applications. Networks of today are going through a rapid evolution. In the last few years we have observed an explosive growth of multimedia computing, communication and applications. This revolution is transforming the way people live, work, and interact with each other, and is impacting the way businesses, education, entertainment, and health care are operating. Presently, a lot of research on high-speed networks and multimedia communication is going on. The papers included in the proceedings cover all aspects of theory, design and application of computer networks and distributed computing systems. W","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":34679810,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/AINA.2006.215","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We will present the status of the LHC proton and ion injector chain as of September 2014. We will briefly recap the main modifications done during LS1, in particular those which influence the LHC beam quality. Then we will review the first months of beam operation of the PS complex machines and the status and plans for commissioning of the SPS. We will in particular focus on the re-start of the injectors after LS1, and highlight thelessons learned and possible improvements for the re-start after LS2. Finally we will have a first look at the first months of the 2015 injector schedule.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":113026843,"openaccessinfo":{"externalids":{"MAG":"2301956687","ACL":null,"DOI":"10.5170\/CERN-2015-002.71","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Endophytes have been identified as reservoirs of novel bioactive secondary metabolites that can serve as a potential candidate for the development of new antimicrobial drugs. The aim of the study was to screen for antibacterial activity of endophytic fungi isolated from Azadirachta indica and Mentha piperita. Endophytic fungi were isolated from healthy leaves of A. indica and M.\u00a0 piperita. The isolates were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Antibacterial activity of ethyl acetate extracts of the isolates was also determined. A total 35 endophytic fungi were isolated out of which 11 showed antibacterial activity against at least two of the test bacterial isolates.\u00a0 Ethyl acetate extracts of these 11 endophytes had varying degree of antibacterial activity with zones of inhibition ranging from 10\u00b110 mm to 26\u00b10.5 mm. Result of this study revealed that endophytic fungi isolated leaves of A. indica and M. piperita produce bioactive compounds with antibacterial activity against the test bacterial isolates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257490816,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.57056\/ajb.v3i2.57","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"http:\/\/journal.univ-eloued.dz\/index.php\/ajb\/article\/download\/57\/47","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Many businesses today save time and money, and increase their agility, by outsourcing mundane IT tasks to cloud providers. The author argues that similar methods can be used to overcome the complexities inherent in increas ingly data-intensive, computational, and collaborative scientific research. He describes Globus Online, a system that he and his colleagues are developing to realize this vision.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":20688299,"openaccessinfo":{"externalids":{"MAG":"2088379928","ACL":null,"DOI":"10.1109\/MIC.2011.64","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Virtually all renal diseases progress, although at different rates, to end-stage renal failure. The main clinical factors which may explain such relentless progression are reviewed and include: the underlying renal pathology, with the most rapid progression rate observed in glomerular disease and in polycystic kidney disease; systemic hypertension, a significant risk factor for progression in any renal disease; the magnitude and duration of proteinuria with the fastest progression rate found in the nephrotic syndrome; the degree of functional renal deterioration at which so called conservative treatment is prescribed. The proper identification of these risk factors may result in rational dietary and non-dietary intervention with the aim of slowing the progression of chronic renal disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24742015,"openaccessinfo":{"externalids":{"MAG":"2414363087","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Partial nephrectomy (PN) either done open, laparoscopic, or robotic is associated with the complication of renal artery pseudoaneurysm (RAP), which is rare but can have grave prognosis. Minimally invasive intervention using endovascular techniques can safely treat this problem with minimal morbidity. We present here two cases of RAP following robotic PN. The first case was a 78-year male patient who underwent robotic PN 3 months prior for a 55 mm \u00d7 53 mm clear cell carcinoma of the left lower renal pole. On his 3-month follow-up computerized tomography (CT), he was incidentally diagnosed with a 48 mm \u00d7 40 mm \u00d7 36 mm well-defined pseudoaneurysm with supply from the lower polar accessory renal artery. The second case was a 42-year male patient who had undergone a robotic PN for a 3.5 cm renal mass. On day 24 postsurgery, he developed hematuria and evaluation with renal CT angiography showed two pseudoaneurysms of approximately 8\u20139 mm each; associated with a hematoma extending from the mid pole of the left kidney to the tail of the pancreas. We managed to successfully embolize the RAPs endovascularly in both the patients; case one with glue and case two with coils. Both patients were discharged on the next day with no side effects, complications, or morbidity. RAP post-PN; though rare, is a dreaded complication that one should be aware of and be able to treat it timely. Knowing how to managing these situations with minimally invasive techniques should be a part of the armamentarium of all endovascular specialists.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":80273146,"openaccessinfo":{"externalids":{"MAG":"2791390448","ACL":null,"DOI":"10.4103\/ijves.ijves_54_17","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/ijves.ijves_54_17","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The vast Lena-Tunguska province in the heart of Siberia is among the world's largest and least explored frontier basins. Some encouraging exploration has nevertheless been carried out in the four southern subbasins: PrePatom (PreBaykal) trough, Nepa-Botuobin anticlise, PreSayan-Yenisey basin, and Angara-Lena terrace. Source rocks are essentially Proterozoic, but younger sediments may contribute about 10% of the region's oil potential. Riphean-Cambrian subsalt reservoirs contribute more than 90% of the hydrocarbons discovered, whereas Cambrian salt provides the most common regional seals. The main hydrocarbon later migration occurred in Vendian-Cambrian. Traps include clastic wedging out along favorable structures and carbonate reef-like buildups. Many traps were transformed or destroyed by the late Paleozoic-early Mesozoic volcanic activity, whereas Hercynian overthrust tectonics developed new traps in the PrePatom trough. About 30 discoveries, mainly gas and condensates, have been made in the area, but operations are hampered by poor logistics and limited infrastructure.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":140586995,"openaccessinfo":{"externalids":{"MAG":"2016243214","ACL":null,"DOI":"10.1306\/0C9B1CAF-1710-11D7-8645000102C1865D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\/introduction Despite presenting indicator conditions, HIV diagnoses are often delayed resulting in higher mortality and morbidity. Aim(s)\/objectives To review the rate of late HIV diagnosis locally and identify factors associated with delayed diagnosis. Methods Retrospective GUM and hospital case note review of all 31 newly diagnosed HIV patients attending the Norwich GUM clinic in 2013. Results 12\/31 (38%) were late presenters with CD4 count persistently below 350 cells\/mm3. At diagnosis 3\/12 had no symptoms or indicator conditions; 2\/12 had symptoms that were immediately acted upon; 7\/12 had indicators illnesses not acted upon in a timely fashion hence the diagnoses were delayed from between 2 months to 2 years. Of these 7 delayed diagnoses 2 presented to GUM and declined testing initially although they were men who had sex with men (MSM). 5\/7 presented as acute admissions; 3 were MSM (2 bisexual), 1 heterosexual male and 1 female. All of the 5 patients presenting with acute admission had medical associations; one was a nurse, 4 had immediate family members or a partner who was a nurse, doctor or pharmacist. The mean age of the male patients who were diagnosed in hospital was 65 years (range 52\u201380 years). Discussion\/conclusion HIV testing may be less likely to be undertaken for older inpatients and those with medical associations.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":58705165,"openaccessinfo":{"externalids":{"MAG":"2417923462","ACL":null,"DOI":"10.1136\/SEXTRANS-2015-052126.125","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues, it remains unclear whether such instructive activity is also critical for directed mesenchymal cell migration. Here, we developed a light-activated version of the non-canonical Wnt receptor Frizzled 7 (Fz7) to analyze how restricted activation of non-canonical Wnt signaling affects directed anterior axial mesendoderm (prechordal plate, ppl) cell migration within the zebrafish gastrula. We found that Fz7 signaling is required for ppl cell protrusion formation and migration and that spatiotemporally restricted ectopic activation is capable of redirecting their migration. Finally, we show that uniform activation of Fz7 signaling in ppl cells fully rescues defective directed cell migration in fz7 mutant embryos. Together, our findings reveal that in contrast to the situation in epithelial cells, non-canonical Wnt signaling functions permissively rather than instructively in directed mesenchymal cell migration during gastrulation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58643050,"openaccessinfo":{"externalids":{"MAG":"2908607257","ACL":null,"DOI":"10.7554\/eLife.42093","PubMedCentral":"6365057","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PROBLEM\nLong turnaround time for radiology reports, unacceptable percentage of misplaced films.\n\n\nSOLUTION\nInstallation of hospitalwide PACS, implementation of voice recognition dictation system, upgrade of RIS.\n\n\nRESULTS\nRapid and significant improvement in reporting times, virtual elimination of misplaced films, integration of radiology services throughout the enterprise.\n\n\nKEYS TO SUCCESS\nDetailed financial model and needs assessment, commitment by management and staff, well-planned implementation, choice of vendor that provides total solution and support.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":34636511,"openaccessinfo":{"externalids":{"MAG":"2407374411","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this contribution, we propose accurate intermolecular benchmarks for the 10 standardized water dimers initially proposed by van Duijneveldt et al., following a study by Smith et al. (J Chem Phys, 1990, 92, 1240). Using the popular triple-zeta aug-cc- pVTZ basis set, symmetry-adapted perturbation theory (SAPT) computations have been performed and compared with supermolecular post-Hartree-Fock techniques up to most recent explicitly correlated methods. Effects of approximated inclusion of third-order corrections to induction and exchange-induction energies are discussed. As SAPT results are close to the best available ab initio ones, detailed analysis of the available individual SAPT contributions to the interaction energy confirms that electron correlation acts not only on its long-range dispersion part but also on its separated physical components. This permits to assess the validity of the usual HFDispersion model as approximation to add pure correlation effects to orbital-based interaction schemes. The study proposes extensive benchmark data in a Supporting Information part to provide useful data for the development and the test of new force field energy functions for water. \u00a9 2009 Wiley Periodicals, Inc. Int J Quantum Chem 109: 3259-3267, 2009","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56304015,"openaccessinfo":{"externalids":{"MAG":"2060256583","ACL":null,"DOI":"10.1002\/QUA.22299","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Nutritional anaemia in India is common morbidity seen in late adolescent and young female population. There are many conflicting opinions regarding dosage of iron folic acid supplementation for managing this simple nutritional deficiency disorder. Hence, this 'Randomized Controlled Trial' was undertaken in adolescent girls suffering from Iron Deficiency Anaemia visiting 'Urban Health and Training Centre' situated in urban slum area. The aim of this study was to assess the (a) Impact of weekly iron folic acid supplementation in comparison with daily iron supplementation for the management of Iron Deficiency Anaemia in adolescent girls visiting 'Urban Health and Training Centre'; (b) Adverse drug reaction profile in 'Weekly Iron Folic Acid Supplementation' and 'Daily Iron Folic Acid Supplementation' regimes; (c) Compliance profile for 'Weekly Iron Folic Acid Supplementation' and 'Daily Iron Folic Acid Supplementation' regimes in adolescent girls. Methods and Material: Randomized controlled trial was conducted in adolescent girls visiting 'Urban Health and Training Centre' during the study period June, 2011 to October, 2012. The 120 anaemic (Haemoglobin < 12 gm%) adolescent girls (10-19 years) were distributed randomly by block randomization in two groups; one receiving daily Iron and Folic Acid supplementation and in other group receiving weekly Iron and Folic Acid supplementation for 3 months. All the study subjects were given de-worming (Albendazole 400 mg) and required health education separately. Both the groups were monitored for Haemoglobin estimation, compliance and adverse drug reactions, if any. Open-Epi Statistical Software was used for data analysis. Results: The mean age of study subjects in 'Daily Iron and Folic Acid Supplementation' and 'Weekly Iron and Folic Acid Supplementation' group was 13.48 and 13.55 years respectively. Their mean pre intervention Haemoglobin was 10.1\u00b11.1 gm\/dl and 10.4\u00b11.1 gm\/dl respectively. The mean rise in Haemoglobin after lean period of 1 month in respective groups was almost equal i.e. 1.0\u00b10.7 gm\/dl and 1.0\u00b10.8 gm\/dl. Adverse Drug Reactions were 8.3% in weekly regime as compared to 13.35% in daily regime, abdominal pain being the commonest adverse drug reaction seen. The compliance calculated as mean of unconsumed 'Iron and Folic Acid' tablets was 6.1\u00b110.98 in 'Daily Iron Folic Acid Supplementation' group, while it was 1.3\u00b13.15 in 'Weekly Iron Folic Acid Supplementation' group (p=0.0012), making weekly regime more promising than daily regime with better treatment compliance. Conclusions: Weekly supplementation of 'Iron and Folic Acid' in 'Iron Deficiency Anaemia' patients is as good as daily supplementation with added benefits of less adverse reactions and better compliance.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":16949706,"openaccessinfo":{"externalids":{"MAG":"1994812525","ACL":null,"DOI":"10.5539\/gjhs.v5n3p188","PubMedCentral":"4776831","ArXiv":null},"license":"CCBY","url":"https:\/\/europepmc.org\/articles\/pmc4776831?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this article is to locate discussions around the need for a Bill of Rights for Northern Ireland within the context of a wider debate across the UK on the role of judges in curbing abuses of power. It will be argued that discourse on the protection of rights in Northern Ireland has been dominated in recent years by a Bill of Rights debate which has focused almost exclusively on how best to incorporate international human rights standards into domestic law via a strong and inclusive Bill of Rights. This approach, it is suggested, has in turn led to positive developments in the UK courts in recent years with regard to common law rights protection being largely overlooked by the Northern Ireland human rights community. As a result, the perception has been created that the only source of law currently available to those seeking redress for violations of rights is under the Human Rights Act 1998. This article seeks to highlight ways in which common law standards, including for example the \"right to consultation\" and the \"right to confrontation\" have delivered the goods in a number of cases in terms of curtailing the actions of the executive. The article will also focus on some recent comments from the Law Lords with respect to the doctrine of the sovereignty of Parliament. Such comments indicate a clear warning to politicians that there are indeed limits beyond which even an Act of the Westminster Parliament might be ruled \"unlawful\" by the courts. The point here is not to suggest that judicial law-making should be a substitute for a strong and inclusive Bill of Rights for Northern Ireland. Rather, the argument in this article is that those seeking to ensure the protection of rights should be familiar with, and be willing to deploy, all the tools at their disposal, including, where appropriate, the common law.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":155637046,"openaccessinfo":{"externalids":{"MAG":"2246202408","ACL":null,"DOI":"10.2139\/SSRN.1623311","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \nPurpose \nTo describe how the digital writing experiences of two collaborating second-grade classrooms are representative of a digital writing cycle that includes barriers, bridges, and outcomes. Additionally, this chapter aims to link theory and practice for teachers working with an increasingly younger generation of multimodal learners by connecting teacher reflections to New Literacies perspectives. \n \n \nDesign\/methodology\/approach \nThe current study is informed by multiple perspectives contributing to New Literacies research. These perspectives blend the traditional disciplines of literacy and technology while recognizing both the growing use of digital tools and the new skills and dispositions required for writing. This chapter uses multiple data points to present (1) how the teachers approached implementation of digital writing tools, (2) how students responded to the use of digital writing tools, and (3) how the digital-related writing experiences aligned with key tenets of New Literacies research. \n \n \nFindings \nThe authors present student barriers for full participation with corresponding bridges implemented by teachers to help students navigate in the digital writing classroom. Each finding is supported with examples from student and teacher interviews as well as classroom observations and artifacts. The chapter concludes with a \"lessons learned\" section from the perspective of the teachers in the study with each tenet supporting a New Literacies perspective by addressing key considerations of multimodal environments such as the importance of early opportunities for teaching and learning with new literacies, the need to help inexperienced students bridge technical skill gaps, and the benefit of social relationships in the digital community. \n \n \nPractical implications \nBy adapting findings of the study to a digital writing cycle, this chapter discusses how guiding principles of New Literacies research reflects classroom practice, thereby granting current and future teachers a practical guide for bridging theory and practice for implementing digital writing experiences for elementary students in multimodal environments.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":63984442,"openaccessinfo":{"externalids":{"MAG":"2550169706","ACL":null,"DOI":"10.1108\/S2048-045820160000007009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective\nTo explore the effectiveness of limited small incision with simple Krackow suture in treatment of acute closed Achilles tendon rupture.\n\n\nMethods\nBetween October 2013 and July 2016, 25 cases with acute Achilles tendon rupture were repaired by simple Krackow suture via limited small incision. There were 21 males and 4 females with an average age of 33.6 years (range, 25-39 years). The left side was involved in 15 cases and the right side in 10 cases. The injury caused by sport in 22 cases and by falling in 3 cases. The time from injury to operation was 3-7 days (mean, 4.4 days). Physical examination showed that the Thompson sign and single heel raising test were positive.\n\n\nResults\nThe operation time was 30-60 minutes with an average of 39.2 minutes. All incisions healed by first intention. There was no complication of wound infection, deep vein thrombosis, tendon re-rupture, and sural nerve injury. All patients were followed up 9-20 months (mean, 14.2 months). The ankle and hindfoot score of American Orthopaedic Foot and Ankle Society (AOFAS) was 92-97 (mean, 94.9) after 9 months. The AOFAS score results were excellent in 13 cases, good in 9 cases, and fair in 3 cases. The range of motion of ankle joint was 49-58\u00b0 with an average of 53.7\u00b0. All single heel raising tests were negative.\n\n\nConclusion\nThe method of simple Krackow suture via limited small incision has the advantages of minimal injury, less incidence of re-rupture and sural nerve injury, quicker recovery and so on.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44138654,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.7507\/1002-1892.201705032","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Deep convection in the Tunuyan Valley region (33 8-348S, 698-708W) on the eastern side of the highest peaks of the Andes Mountains is sometimes associated with damaging hail. Understanding the physical mechanisms responsible for the occurrence of deep convection in that region is therefore a central part of the development of hail suppression projects. In this paper, a case of deep convection that occurred on 22 January 2001 is studied in detail through a combined analysis of radar, satellite, and radiosonde data and numerical simulations using a nonhydrostatic mesoscale atmospheric (Meso-NH) model. The time evolution and stability characteristics are first documented using the data. In order to get insight into the main causes for the deep convection event, numerical simulations of that day were performed. These results are compared with the results corresponding to conditions of 4 January 2001 when no deep convection occurred. The comparison between the 2 days strongly suggests that the deep convection event occurred because of the simultaneous presence of anabatic winds, accumulation of moist enthalpy, and the stability conditions. The present results should be helpful in designing future observational programs in the region.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":55565207,"openaccessinfo":{"externalids":{"MAG":"3046810011","ACL":null,"DOI":"10.1175\/1520-0493(2004)132<2259:ADCEAT>2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper provides an overview of recent historical research regarding scientifically-informed challenges to the idea that the stars are other suns orbited by other inhabited earths \u2013 an idea that came to be known as 'the Plurality of Worlds'. Johannes Kepler in the 17th century, Jacques Cassini in the 18th and William Whewell in the 19th each argued against 'pluralism' based on what in their respective times was solid science. Nevertheless, pluralism remained popular despite these and other scientific challenges. This history will be of interest to the astronomical community so that it is better positioned to avoid difficulties should the historical trajectory of pluralism continue, especially as it persists in the popular imagination.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":260643104,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1017\/s1473550423000174","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Dependence of crystal symmetry, electrical conductivity, chemical state of Fe and optical property of LnFeO 3 (Ln: La, Pr, Nd, Sm) on kinds of Ln 3 + was investigated. All the LnFeO 3 showed orthorhombic structure, with which order of high crystal symmetry was LaFeO 3 > PrFeO 3 > NdFeO 3 > SmFeO 3 . Using tolerance factor, the order was successfully explained. The electrical conductivity of all the specimens could be explained by using small polaron hopping model. With increasing crystallite symmetry, electrical conductivity increased and activation energy for hopping conduction decreased. This can be ascribed to larger overlapping of Fe3d orbital and O2p orbital on nearly linear Fe \u00ad O \u00ad Fe bond in LnFeO 3 with higher crystal symmetry. The larger overlapping of Fe3d orbital and O2p orbital in LnFeO 3 with higher crystal symmetry can also be an origin of larger spin \u00ad spin interaction detected by M\u00f6ssbauer spectroscopy and larger optical band gap observed by diffuse re fl ectance spectroscopy. Since chemical state of Fe, evaluated by M\u00f6ssbauer spectroscopy, in LnFeO 3 is fundamentally constant at + 3 regardless of kinds of Ln 3 + , carrier concentration of LnFeO 3 was revealed to be constant. It is concluded that the predominant factor which determine the electrical property of LnFeO 3 is mobility affected","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":138354090,"openaccessinfo":{"externalids":{"MAG":"2220446433","ACL":null,"DOI":"10.2109\/JCERSJ2.123.501","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nowadays, organizations collect vast quantities of accounting relevant transactions, referred to as 'journal entries', in 'Enterprise Resource Planning' (ERP) systems. The aggregation of those entries ultimately defines an organization's financial statement. To detect potential misstatements and fraud, international audit standards demand auditors to directly assess journal entries using 'Computer Assisted AuditTechniques' (CAATs). At the same time, discoveries in deep learning research revealed that machine learning models are vulnerable to 'adversarial attacks'. It also became evident that such attack techniques can be misused to generate 'Deepfakes' designed to directly attack the perception of humans by creating convincingly altered media content. The research of such developments and their potential impact on the finance and accounting domain is still in its early stage. We believe that it is of vital relevance to investigate how such techniques could be maliciously misused in this sphere. In this work, we show an adversarial attack against CAATs using deep neural networks. We first introduce a real-world 'thread model' designed to camouflage accounting anomalies such as fraudulent journal entries. Second, we show that adversarial autoencoder neural networks are capable of learning a human interpretable model of journal entries that disentangles the entries latent generative factors. Finally, we demonstrate how such a model can be maliciously misused by a perpetrator to generate robust 'adversarial' journal entries that mislead CAATs.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":203952190,"openaccessinfo":{"externalids":{"MAG":"2979487223","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1910.03810"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The drift in the mean values of the charge and mass distributions in deep-inelastic heavy-ion collisions is studied. An explanation of this drift based on a static potential energy surface is seen to be sometimes successful, but generally inadequate. However, the time-dependent Hartree-Fock theory reproduces the fragment mean charge and mass values satisfactorily in the anomalous cases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120524025,"openaccessinfo":{"externalids":{"MAG":"1975369818","ACL":null,"DOI":"10.1088\/0305-4616\/9\/1\/005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this study, optimization and modeling of leaching parameters affecting nickel dissolution from lateritic ore in EskiA\u2026\u0178ehir (MihalA\"\u00b1ccA\"\u00b1k-Yunusemre) were investigated using Box-Behnken design. Stirring speed (100-400 rpm, temperature (40-80\u00b0C), acid concentration (0.1-2 M) and dissolution time (30-180 min) were selected as experimental design parameters. 27 experiments were carried out by Box-Behnken experimental design in Minitab 16.0 program. After leaching experiments, the highest Ni dissolution percentages were obtained as 87.85%. The effective parameters and their interactions in nickel dissolution are described with a mathematical model. The results obtained from the experiments were subjected to ANOVA and multiple regression analysis. The R2 value of the model for nickel dissolution was calculated as 0.980. This showed that the predicted values are in good agreement with the observed values. In addition, three-dimensional response surface and contour graphs of the parameters affecting nickel dissolution efficiency were created and the results were examined.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":215762029,"openaccessinfo":{"externalids":{"MAG":"3011867397","ACL":null,"DOI":"10.37421\/jreac.2020.7.263","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.37421\/jreac.2020.7.263","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background: Craniovertebral junction (CVJ) schwannomas are rare, with surgery and stereotactic radiosurgery (SRS) being effective yet challenging options. We systematically reviewed the literature on CVJ schwannomas. Methods: PubMed, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA statement to include studies reporting CVJ schwannomas. Clinical features, management, and outcomes were analyzed. Results: We collected 353 patients from 101 included articles. Presenting symptoms were mostly neck pain (30.3%) and headache (26.3%), with most cranial neuropathies involving the XII (31.2%) and X (24.4%) nerves. Most tumors originated from C2 (30.9%) and XII (29.4%) nerves, being extracranial (45.1%) and intradural-extradural (44.2%). Erosion of C1\u2013C2 vertebrae (37.1%), the hypoglossal canal (28.3%), and\/or jugular foramen (20.1%) were noted. All tumors were operated, preferably with the retrosigmoid approach (36.5%), with the far-lateral approach (29.7%) or with the posterior approach and cervical laminectomy (26.9%), far-lateral approaches (14.2%), or suboccipital craniotomy with concurrent cervical laminectomy (14.2%). Complete tumor resection was obtained most frequently (61.5%). Adjuvant post-surgery stereotactic radiosurgery was delivered in 5.9% patients. Median follow-up was 27 months (range, 12\u2013252). Symptom improvement was noted in 88.1% of cases, and cranial neuropathies showed improvement in 10.2%. Post-surgical complications occurred in 83 patients (23.5%), mostly dysphagia (7.4%), new cranial neuropathies (6.2%), and cerebrospinal fluid leak (5.9%). A total of 16 patients (4.5%) had tumor recurrence and 7 died (2%), with median overall survival of 2.7 months (range, 0.1\u2013252). Conclusions: Microsurgical resection is safe and effective for CVJ schwannomas. Data on SRS efficacy and indications are still lacking, and its role deserves further evaluation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250470795,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/curroncol29070384","PubMedCentral":"9319499","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1718-7729\/29\/7\/384\/pdf?version=1657599632","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Monoclonal antibodies have emerged as an attractive and successful class of molecules for therapeutic intervention in several areas of human disease. However, evidence is accumulating that targeting a single protein, or single epitope on a protein, is not sufficient to achieve efficacy in certain diseases. The therapeutic range of monoclonal antibodies may therefore be more limited than anticipated. How can multiple antigen targeting be achieved and in what setting can it be beneficial? Intense efforts in antibody engineering have explored different ways to reach this goal and have yielded innovative classes of molecules presenting intrinsic advantages as well as challenges at different development stages.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207494933,"openaccessinfo":{"externalids":{"MAG":"2108912798","ACL":null,"DOI":"10.1517\/17460441.3.8.833","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background\/foreground segmentation has a lot of applications in image and video processing. In this paper, a segmentation algorithm is proposed which is mainly designed for text and line extraction in screen content. The proposed method makes use of the fact that the background in each block is usually smoothly varying and can be modeled well by a linear combination of a few smoothly varying basis functions, while the foreground text and graphics create sharp discontinuity. The algorithm separates the background and foreground pixels by trying to fit pixel values in the block into a smooth function using a robust regression method. The inlier pixels that can fit well will be considered as background, while remaining outlier pixels will be considered foreground. This algorithm has been extensively tested on several images from HEVC standard test sequences for screen content coding, and is shown to have superior performance over other methods, such as the k-means clustering based segmentation algorithm in DjVu. This background\/foreground segmentation can be used in different applications such as: text extraction, separate coding of background and foreground for compression of screen content and mixed content documents, principle line extraction from palmprint and crease detection in fingerprint images.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":4328390,"openaccessinfo":{"externalids":{"MAG":"2138147470","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1412.5126"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Yuriy P. Yekhlakov - Professor, Head of Department of Data Processing Automation, Tomsk State University of Control Systems and RadioelectronicsAddress: 40, Prospect Lenina, Tomsk, 634050, Russian FederationE-mail: firstname.lastname@example.com K. Malakhovskaya - Assistant Professor, Department of Data Processing Automation, Tomsk State University of Control Systems and RadioelectronicsAddress: 40, Prospect Lenina, Tomsk, 634050, Russian FederationE-mail: email@example.com On the basis of conditions of low-budget software product promotion on the market, applied aspects of semiotics, methods of artificial intelligence and the results of practical experience of advertising agencies with Internet advertising for promotion on the corporate market of goods and services, this article proposes a method for developing design pattern for creating the content of communication messages (CM). The article presents a semantic network which describes the model for developing CM design patterns. It identifies key network concepts: the software product, consumer properties, positioning strategy, potential consumers, consumer preferences, features of information perception, a unique proposal, message distribution tools. Associative links between concepts are described. Elements of a semantic network dictionary are offered: the object of definitions, the characteristics of objects, the semantic units of characteristics; semantic unit description of lexical construction dictionary elements - target, key, alternative. Target lexical constructions describe and specify the format of the advertising message in the template. Key lexical constructions determine unique characteristics of the objects' concept. Alternative lexical constructions are designed to strengthen the influence of semantic units and to exert additional impact on potential users. Communication message templates are combinations of semantic units with suggested messages that are most likely to motivate consumers to take certain actions. For practical approval of the use of templates for designing CM in product promotion to the corporate market, a multi-layered production semantic network has been developed. Network layer multiplicity matches a variety of concepts. Each layer consists of a set of objects that reflect the qualitative composition of the layer. The procedure for selecting variants of communication message templates is a non-cyclic chain of the semantic network using production rules. There are consistently selected elements: the representative of the target audience, the type of consumer behavior, the positioning strategy, the tool for disseminating communication messages, the structural element of communication messages. The results obtained can be useful for directors and managers of small IT companies in organizing Internet advertising of their products.The work is conducted under the government assignment of the Ministry of Education and Science of the Russian Federation, project No. 8.8184.2017\/8.9","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":86456609,"openaccessinfo":{"externalids":{"MAG":"2908116621","ACL":null,"DOI":"10.17323\/1998-0663.2018.1.50.60","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.17323\/1998-0663.2018.1.50.60","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We investigate the investments made by accounting firms into recruiting and training new employees into entry-level positions. This includes developing a model to capture both the direct and indirect investments\/ costs associated with recruitment and training. We quantify time, effort, resources, and associated opportunity costs, on entry-level recruits. The model was converted into a quantitative questionnaire and administered to accounting firms. We administered it to twelve accounting firms. The findings from this study build upon earlier studies (Bliss, 2001; Hansen, 1997; Phillips, 1990) which estimated the cost to recruit and train new employees at approximately 150% of their annual salary. Results revealed that the true investment in recruitment and training is significantly greater for the accountants in our study. On average accountants in our study invest an additional 241% of new employees' annual salary. The findings provide insight into the true financial investments firms make during recruitment and the first year of employee training for entry-level positions. Our model is a simple tool which managers can use to quantify their investments in new employees during their first year of employment. It has proved insightful for accounting firms and has potential for use in other industries. Further, we found that generally new employees do not reach full productivity within their first year of employment. This highlights the importance for employers to retain new employees to maximise their returns on investment.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1}},"corpusid":167585429,"openaccessinfo":{"externalids":{"MAG":"2141704506","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aims: Hypophosphatasia, a rare inherited disease characterized by defective mineralization of bone and teeth, is caused by various mutations in the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) gene. Our aim was to determine the mutations on TNSALP gene in three Chinese children diagnosed as having hypophosphatasia. Methods: Genomic DNA was extracted from whole blood samples of patients and their parents. The TNSALP coding regions were then sequenced. Plasmids expressing wild-type or various mutants were built and in vitro studies were performed in order to determine whether these amino acid replacements could affect the TNSALP enzymatic activity. Results: Six missense mutations were identified from three independent pedigrees. Of the six missense mutations, four were novel and two had been previously reported. The Y28D, A111T and T389N mutants displayed only negligible ALP activity in vitro compared to the wild-type (WT) TNSALP. The defect was mainly due to the significantly decreased protein expression in the 66 KD immature forms and the nearly undetectable protein expression in the 80 KD mature forms. Moreover, all three mutants had a dominant negative effect on the WT protein when co-transfected with TNSALP (WT). M219V and R136L mutants both exhibited partial enzymatic activities which were consistent with reduced protein expression in both forms of TNSALP which further exhibited moderate dominant-negative effect. In addition, Y388H mutant showed weak ALP activity. Western blot analysis indicated that the extreme reduction in signal from the mature forms of TNSALP could be the main cause of decreased enzymatic activity, since a strong signal was observed in the immature forms. Conclusion: Six missense mutations were identified in three Chinese hypophosphatasia pedigrees with subnormal serum ALP activity. Our results show that the low activity of serum ALP in the three patients is due mainly to a defect in the protein expression of the mutants. This may be the underling molecular mechanism for hypophosphatasia in these patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5642972,"openaccessinfo":{"externalids":{"MAG":"2054500301","ACL":null,"DOI":"10.1159\/000354467","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/karger.com\/cpb\/article-pdf\/32\/3\/635\/2425742\/000354467.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We report hybrid density functional theory calculations for inelastic electron tunneling spectroscopy (IETS) of a single metallofullerene Gd@C82. It is found that the metal atom inside the carbon cage can have significant impact on the IETS spectral profiles of the system, by modulating both the vibration and electron density. It is demonstrated that the IETS signals are very sensitive to the changes in the metal position and charge states, so that provide a unique tool for identifying the metal-cage coupling in metallofullerenes.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":97027615,"openaccessinfo":{"externalids":{"MAG":"2077949750","ACL":null,"DOI":"10.1063\/1.3455905","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this article we discuss the problem of one-way image transmission through multi-layer of thin distorting media: a special case of thick distorter. We prove the possibility of transmitting image through two layers, as well as multi-layer, of thin distorting media via degenerate four-wave mixing. The theoretical analysis is verified by the experimental results for two thin distorters.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250881748,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0256-307X\/3\/9\/001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on the results of an experimental preliminary investigation, two correlations are presented between the standard 28-day strengths of 2-in. (50-8-mm) portland cement mortar cube specimens and the strengths of companion specimens cured under standard conditions for 1 day, and then subjected to accelerated curing for 1, 2, and 3 days in a water bath at 95 degrees C. The proposed correlations, although by no means conclusive, seem to indicate that a unified approach to prediction of standard 28-day strengths may be possible without resorting to development of individual \"standard curing-accelerated curling\" relationships for each kind of cement of different quality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":135999772,"openaccessinfo":{"externalids":{"MAG":"760436227","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The influence of the substitutional atoms Cr, Mn, Ni, Cu, Mo in iron-based alloys on the stability of the crystalline fcc structure and the change of the electron state density at the Fermi surface are studied by means of conduction electron spin resonance (CESR). The temperature dependence of the CESR g-factor and of its integral intensity is measured and analysed in relation to theoretical predictions. It is shown that Cr, Mn and Mo decrease the state density at the Fermi surface in the fcc iron, whereas Ni and Cu increase it. The study singles out the contributions of three electron subsystems (conduction s electrons, localized isolated d electrons and those included in superparamagnetic clusters) to g(T) and traces the important role of substitutional alloying elements in the formation of clusters in fcc solid solution.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":96249636,"openaccessinfo":{"externalids":{"MAG":"2011584615","ACL":null,"DOI":"10.1088\/0953-8984\/10\/8\/015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Edited by Brownson RC, Petitti DB. 384: Published by Oxford University Press, 2006, $59.95 (05) (hardback). 13: 978-0-19-518741-0, 10: 0-19-518741-5\n\nApplied epidemiology is not a classical book on epidemiology. This text focuses on areas of public health practice in which the systematic application of epidemiological methods can have a large and positive impact. It describes how best to apply traditional epidemiological methods for determining disease aetiology to \"real-life\" problems in public health and health services research. Topics covered in this book highlight the multidisciplinary nature of epidemiology.\n\nEach chapter includes a summary and one or more case studies intended to illustrate major points from the chapter and to provide a basis \u2026","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":74503550,"openaccessinfo":{"externalids":{"MAG":"2166396464","ACL":null,"DOI":"10.1136\/JECH.2007.059543","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pulmonary rehabilitation is important to prevent complications in critically ill patients in the intensive care unit (ICU) who are on mechanical ventilation. However, the effectiveness and adverse events related to pulmonary rehabilitation for patients in the ICU are largely unclear because of the diversity of diseases and various levels of severity in this situation. This review aims to clarify the evidence currently available for pulmonary rehabilitation in critically ill adult patients requiring mechanical ventilation, with a focus on positioning and early mobilization. Prone positioning (PP) does not seem to benefit adults with hypoxemia mechanically ventilated in the ICU. However, it improved survival among patient subgroups like those enrolled within 48 h of meeting the trial entry criteria, those treated with PP for \u226516 h per day, and those with severe hypoxemia at trial entry. PP using the protective lung ventilation strategy for patients with acute respiratory distress syndrome was associated with reduced mortality. On the other hand, PP may cause pressure sores and tracheal tube obstruction. The semi-recumbent position may prevent ventilator-associated pneumonia with no adverse events. Early mobilization (EM) enhances mobility status and muscle strength and increases days of life and out of the hospital for up to 6 months; it also shortens the duration of delirium. The main adverse events with EM are hemodynamic changes and desaturation. Therefore, medical staff should carry out pulmonary rehabilitation for patients in the ICU, given the effectiveness and adverse events. Future studies should identify diseases that would benefit from pulmonary rehabilitation and optimize the method.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79804793,"openaccessinfo":{"externalids":{"MAG":"2728475342","ACL":null,"DOI":"10.17140\/PRRMOJ-SE-2-107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 102nd Annual Meeting 2011\u2010\u2010 Apr 2\u20106, 2011; Orlando, FL\n\nIn patients with locally advanced breast cancer, radiation therapy (RT) and chemotherapy following surgery has been a mainstay of treatment with demonstrated survival advantage in numerous randomized trials. However, despite recent advances in treatment, many women still ultimately succumb to disease highlighting the need to improve therapeutic strategies. Results from several groups have recently revealed that the therapeutic effects of RT are in part dependent on activation of immune-mediated mechanism(s); however, little is known regarding the mechanistic details of this activation. To address this, we examined changes in the immune microenvironment of mammary carcinomas following RT. We found that following RT (5 Gy), the density of infiltrating macrophages was significantly increased (20 vs 35%, p = 0.02) as compared to mammary tumors in mice not receiving RT. When macrophages were depleted following RT, via use of a CSF-1 antagonist, a significant delay in tumor growth, as compared to tumors treated with RT alone was observed. Since this data indicated that macrophage infiltration blunted RT responsiveness, we hypothesized that reprogramming tumor-infiltrating macrophages more towards a classical cytotoxic phenotype would result in enhanced RT response and delayed tumor re-growth. Thus, we treated tumor-bearing mice with anti-IL-4 neutralizing mABs in combination with RT, and evaluated tumor re-growth, as compared to tumor-bearing mice treated with either RT or anti-IL4 mAB alone, and found that indeed, reprogramming tumor-infiltrating macrophages to favor classical (M1)-type activity significantly enhanced RT response and delayed tumor re-growth. Together these studies indicate that: 1) RT induces macrophage infiltration into mammary tumors, 2) protumor-type macrophages infiltrating mammary carcinomas blunt response to RT, and 3) reprogramming of tumor-infiltrating macrophages to favor a cytotoxic phenotype improves efficacy of RT.\n\nThis work was supported by grants from the NIH\/NCI, and Era of Hope (W81XWH-06-1-0416), and Program in Mesothelioma (PR080717) grants from the Department of Defense to LMC.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2840. doi:10.1158\/1538-7445.AM2011-2840","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":71519823,"openaccessinfo":{"externalids":{"MAG":"1997252679","ACL":null,"DOI":"10.1158\/1538-7445.AM2011-2840","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since the first successful organ transplant conducted between twins in 1954, kidney transplant has evolved considerably over the past 50 years. Kidney transplant plays an important role in the treatment of end-stage kidney disease to improve the quality of life and prolong the life of patients. Despite significant advances, postoperative medical and surgical complications still represent important causes of morbidity and mortality. Many problems can be avoided through prophylactic correction of abnormalities detected during the preoperative evaluation; however, it is critical that technical mishaps at all stages of the transplant process (donor nephrectomy, benchwork preparation, and implant) be prevented and that careful postoperative monitoring be carried out, including thorough examination by attending physicians. However, despite these advances, surgical complications still present serious problems in kidney transplant recipients.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":45184363,"openaccessinfo":{"externalids":{"MAG":"2593932547","ACL":null,"DOI":"10.6002\/ECT.2016.0290","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bioassay is the measurement of the potency of a chemical substance by its effect on a living animal or plant tissue. Bioassay data and chemical structures from pharmacokinetic and drug metabolism screening are mined from and housed in multiple databases. Bioassay prediction is calculated accordingly to determine further advancement. This paper proposes a four-step preprocessing of datasets for improving the bioassay predictions. The first step is instance selection in which dataset is categorized into training, testing, and validation sets. The second step is discretization that partitions the data in consideration of accuracy vs. precision. The third step is normalization where data are normalized between 0 and 1 for subsequent machine learning processing. The fourth step is feature selection where key chemical properties and attributes are generated. The streamlined results are then analyzed for the prediction of effectiveness by various machine learning algorithms including Pipeline Pilot, R, Weka, and Excel. Experiments and evaluations reveal the effectiveness of various combination of preprocessing steps and machine learning algorithms in more consistent and accurate prediction. Keywords\u2014Bioassay, machine learning, preprocessing, virtual screen.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":3902448,"openaccessinfo":{"externalids":{"MAG":"2793867624","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ecosystem within the lending industry and beyond is a ULS system. Existing business data and process centric standards have very limited governing power over the quality and evolution of such ULS systems. We have helped to develop an initial reference architecture and associated development guidelines for a lending industry e-business standard, to assist in solving current problems and to promote more sophisticated use of the standard in the context of the LIXI ULS system. The nature of such RA should be quality-centric rather than structure-centric. We have proposed a few technical solutions to help achieve this.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":17024136,"openaccessinfo":{"externalids":{"MAG":"2195009376","ACL":null,"DOI":"10.1109\/ICSEW.2007.179","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceeding from analysis of ample postmortem material--25,589 autopsies for 25 years (1963-1987)--the authors have found that most cases of pancreas cancer were in the fourth, fifth, sixth and seventh decade of life with a peak in the sixth decade. It is important to note that the ratio by sex in the most frequently affected age groups was as follows: in the fourth and the seventh decade 3:1 in favor of males; in the fifth decade 2:1 in favor of males and in the sixth decade 1:1. The unequal proportion of cases between males and females during the fourth and the seventh decade, the relative decrease in the difference in the fifth decade and almost equal incidence in the two sexes during the sixth decade, is of definite importance for the clinical diagnosis and prognosis of the disease. Analysis of the data showed that cancer of the head of the pancreas was the most common localization both in males and in females, followed by the body, the tail and simultaneously in the head and the body. The proportion between males and females as to cancer of the head of the pancreas was approximately 2:1 in favor of males; for cancer of the body the proportion was 3:2 also in favor of males; as for cancer of the tail and of the head + body, the proportions were almost equal-2:1 in favor of males. For all other localization of cancer in the gland the proportions were statistically insignificant because of the small number of cases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28572476,"openaccessinfo":{"externalids":{"MAG":"2409026927","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The properties and characteristics of native rice starch and dual-modified rice starch in relation to dual-modified rice starch films were investigated. In this study, the rice starch was hydroxypropylated with 6\u201312% of propylene oxide followed by crosslinking with 2% sodium trimetaphosphate (STMP). Increasing of propylene oxide concentrations in the dual-modified rice starch yielded an increase in the molar substitution (MS) and degree of substitution (DS) of the modified rice starch. However, the pasting temperature, paste consistency, breakdown, setback and gel strength showed an inverse trend. Biodegradable films were prepared from the dual-modified rice starch. The results showed that the maximum tensile strength (TS) was presented when using the 8% propylene oxide. The Elongation at break (%E) and film solubility (FS) of the films were higher than native rice starch and these tended to increase when the concentration of propylene oxide increased. However, the water vapor permeability (WVP) of the films was lower than the native rice starch and these did not significantly change with an increase in the concentration of propylene oxide ( p >0.05).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":99700373,"openaccessinfo":{"externalids":{"MAG":"2608102370","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lodicules are important organs creating the mating system in grasses, in a range between autogamy in clestogamous flowers and allogamy in chasmogamous flowers. This balance is the main factor determining variation patterns in plant populations. Recognition of variation in lodicule morphology is especially important in wheat, the main crop of the world. For this reason, a broad range of species of wheat was evaluated by means of characters showing the leafy nature of lodicules. The characters were studied under polarizing and epifluorescence microscopes. Development of lodicule stomata is different than that in leaves. Development of stomata and xylem, is distinctly correlated. Other short cells created by epidermal meristemoids are developmentally rather independent of both stomata and xylem. Interrelations between stomata, xylem and morphogenetic traits of the abaxial epidermis of the lodicule are illustrated by pictures and diagrams of numerical analyses, including a non-metric multidimensional scaling method. Some unthreshable wheats, such as Triticum diccocum, T. ispahanicum and T. spelta, have more leafy lodicules, but intraspecific variation appears in the form of +leafy vs. \u2212leafy lodicules. Formation of leafy lodicule morphs does not depend on the ploidy level of wheat. An intraspecific mosaic of + or \u2212leafy lodicules proves a mutational origin of their leafy characters.\u00a0\u00a9 2010 The Linnean Society of London, Botanical Journal of the Linnean Society, 2010, 164, 303\u2013316.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":82519563,"openaccessinfo":{"externalids":{"MAG":"1484105074","ACL":null,"DOI":"10.1111\/J.1095-8339.2010.01090.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Langaco Lake (LGL) is a strong Na2CO3-type lake that sits at an altitude of 4,548 m in the Qinghai-Tibet Plateau of China. LGL exhibits unique hydrochemical characteristics among Na2CO3-type lakes, but little is known about the microbial diversity of LGL and their interactions with environmental factors. Here, high-throughput sequencing of 16S rRNA genes revealed that LGL bacterial diversity comprised 327 genera in 24 phyla (4,871 operational taxonomic units [OTUs]; Shannon index values of 5.20\u20136.07) that represented significantly higher diversity than that of Archaea (eight phyla and 29 genera comprising 1,008 OTUs; Shannon index values of 2.98\u20133.30). The bacterial communities were dominated by Proteobacteria (42.79\u201353.70% relative abundances), followed by Bacteroidetes (11.13\u201315.18%), Planctomycetes (4.20\u201312.82%), Acidobacteria (5.91\u20139.50%), Actinobacteria (2.60\u20135.80%), and Verrucomicrobia (2.11\u20134.08%). Further, archaeal communities were dominated by Crenarchaeota (35.97\u201358.29%), Euryarchaeota (33.02\u201339.89%), and Woesearchaeota (6.50\u201321.57%). The dominant bacterial genus was Thiobacillus (8.92\u201316.78%), whose abundances were most correlated with total phosphorus (TP), pH, CO32\u2212 concentrations, and temperature. The most abundant archaeal genus was Methanoregula (21.40\u201328.29%), whose abundances were most highly correlated with TOC and TS in addition to the concentrations of K+, and Na+. Taken together, these results provide valuable insights towards a more comprehensive understanding of microbial diversity in these unique carbonate alkaline environments, in addition to a better understanding of microbial resources in the Qinghai-Tibet Plateau.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":246570983,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-1243484\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-1243484\/latest.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Rare, but potentially debilitating, injuries in the athlete may originate from trauma to the sesamoid bones of the great toe. Controlled studies comparing conservative versus surgical treatment outcomes are lacking owing to the limited number of suspected and proven cases of sesamoid stress fracture or sesamoiditis, a nondescript, painful condition involving the sesamoid. Thus, familiarity with the anatomy and congenital variations of the sesamoid is necessary to identify possible pathology in this area. Existing studies of surgical and nonsurgical treatment of athletes with great toe sesamoid injuries are reviewed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5820891,"openaccessinfo":{"externalids":{"MAG":"153192722","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"My interest into reflection and portfolio construction was developed during the 2005 Contexts for Teacher Education Module on the EdD course at the Nottingham University. Experiencing and observing some significant problems with the current portfolio stimulated me to undertake a study on portfolio construction by integrating reflection into it. The aim of this study was to examine student teachers' perceptions of their experiences of constructing a portfolio in order to develop a more reflective portfolio construction tool. \n\nThe research was conducted in the Department of Educational Sciences at Eastern Mediterranean University in North Cyprus, focusing on the EDUC 420 Practice Teaching course which is a fourth-year course in B.A in English Language Teaching. Methodologically, the researcher has adopted action research since the phases of the study best suits to the nature of action research. The study consisted of three phases, the first phase of which focused on the student teachers' perceptions of their experiences with the currently used portfolio tool and attempted to diagnose the problematic areas of it as well as its strengths. In the second phase, the researcher attempted to develop a more reflective portfolio construction tool based on the findings of the first phase and on the related theoretical\/empirical knowledge. The third phase was concerned with the implementation of the newly developed portfolio tool and reported on the effectiveness of it. Four broad research questions guided both phases of the study. Interviews and end-of-the-semester reflection essays were used as sources of data and content analysis was done to analyse the data in both the first and the third phases of the study. \n\nThe impact of portfolio in increasing self-awareness, improving certain thinking skills and the importance of communication student teachers had with the supervisor\/cooperating teacher during portfolio construction process were underlined. Lack of sufficient feedback and guidance, of continuous supervision and monitoring, and of depth, diversity and perspective in the guidelines of the reports have been reported as significant weaknesses of the currently used portfolio tool. Specific and focused questions to be integrated into the journals, peer collaboration to be incorporated into the processes and close follow up of all the components and processes were given as suggestions for modification in the first phase of the study.\n\nIn the third phase of the study, student teachers reported that the components of the newly developed portfolio tool increased their self-awareness as prospective teachers making them more conscious of what potentials they have or lack and enabling them to understand or relate theories with practice. Student teachers indicated that they were able to produce solutions since the components of the portfolio guided them to define their weaknesses by examining the underlying reasons. This was achieved through the step-by-step approach and the guiding questions given in the journals\/reports which enabled them to think from multiple perspectives and to behave differently in different situations which contributed to their critical thinking skills. They also claimed that they did not find the observation tasks useful and underlined the importance of the communication and interaction rather than observation in getting acquainted with the students. \n\nStudent teachers reported that the communication and the dialogue held during the feedback sessions provided multiplicity of voices and helped them develop their critical and reflective thinking skills through the questions posed and the reasoning and comments made during guidance. \n\nStudent teachers reported that peer collaboration helped them improve their critical thinking skills by helping them develop a 'critical eye' which enabled them to observe objectively and consciously. However, they also reported about the weaknesses of the peer collaboration suggesting for a necessity of continuous peer observation and of the suitability of partners in improving the weaknesses. The guiding questions, continuous guidance and peer collaboration tasks acted as the instructional scaffolds promoting reflective and self-assessment skills of the student teachers.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":109862145,"openaccessinfo":{"externalids":{"MAG":"1525804341","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although Transposable Elements (TEs) comprise a major fraction of many higher eukaryotic genomes, most TEs are silenced by host defense mechanisms. The means by which otherwise active TEs are recognized and silenced remains poorly understood. Here we analyzed two independent cases of spontaneous silencing of the active maize Ac\/Ds transposon system. This silencing was initiated by Alternative Transposition (AT), a type of aberrant transposition event that engages the termini of two nearby separate TEs. AT during DNA replication can generate Composite Insertions (CIs) that contain inverted duplications of the transposon sequences. We show that the inverted duplications of two CIs are transcribed to produce dsRNAs that trigger the production of two distinct classes of siRNAs: a 24-nt class complementary to the TE terminal inverted repeats (TIRs) and non-coding sub-terminal regions, and a 21-22 nt class corresponding to the TE transcribed regions. Plants containing these siRNA-generating CIs exhibit decreased levels of Ac transcript and heritable repression of Ac\/Ds transposition. This study documents the first case of TE silencing attributable to transposon self-initiated AT and may represent a general initiating mechanism for silencing of DNA transposons. Article summary Transposable Elements (TEs) are often silenced by their hosts, but how TEs are initially recognized for silencing remains unclear. Here we describe two independent loci that induce de novo heritable silencing of maize Ac\/Ds transposons. Plants containing these loci produce dsRNA and Ac-homologous small interfering RNAs, and exhibit decreased levels of Ac transcript and heritable repression of Ac\/Ds transposition. We show that these loci comprise inverted duplications of TE sequences generated by Alternative Transposition coupled with DNA re-replication. This study documents the first case of transposon silencing induced by AT and may represent a general initiating mechanism for TE silencing.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":213009712,"openaccessinfo":{"externalids":{"MAG":"2999636446","ACL":null,"DOI":"10.1101\/2020.01.07.897926","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1101\/2020.01.07.897926","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"HLA-DRB1*0401 has been associated with predisposition to develop rheumatoid arthritis (RA) while *0402 has been linked with resistance to develop RA. Using transgenic mice, we showed that *0401 mice are susceptible to develop collagen-induced arthritis (CIA) that mimics human disease in histopathology, production of autoantibodies and sex-bias while *0402 mice are not susceptible. In this study, we determined if *0401 mice have CD4 T cell repertoire that is predetermined to produce proinflammatory cytokines. The data shown here supports that both *0401 and *0402 mice can produce Th1\/TH17 cytokines although conditions required for production of Th17 cytokines differ between the 2 strains. In context of CIA, *0402 mice generate a Th2 response that may explain its resistance to develop CIA. Further, our data supports that a significant subset of na\u00efve CD4 T cells when activated in polarizing conditions can generate T regulatory cells in *0402 but not *0401 mice. We hypothesize that *0401 has been evolutionarily selected due to its ability to clear infection. Our data suggests that *0401 generates a storm of cytokines in response to bacterial products and may be more efficient in clearing infection than *0402. Autoimmunity is a bystander effect of the cytokine storm ensuing immune dysregulation along with the presence of lower number of T regulatory cells in *0401 mice.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":255630117,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.190.supp.175.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Similar to patients with chronic hypertension, spontaneously hypertensive rats (SHR) develop fast core progression during middle cerebral artery occlusion (MCAO) resulting in large final infarct volumes. We investigated the effect of Sanguinate\u2122 (SG), a PEGylated carboxyhemoglobin (COHb) gas transfer agent, on changes in collateral and reperfusion cerebral blood flow and brain injury in SHR during 2\u2009h of MCAO. SG (8\u2009mL\/kg) or vehicle (n\u2009=\u20096\u20138\/group) was infused i.v. after 30 or 90\u2009min of ischemia with 2\u2009h reperfusion. Multi-site laser Doppler probes simultaneously measured changes in core MCA and collateral flow during ischemia and reperfusion using a validated method. Brain injury was measured using TTC. Animals were anesthetized with choral hydrate. Collateral flow changed little in vehicle-treated SHR during ischemia (\u22128\u2009\u00b1\u20099% vs. prior to infusion) whereas flow increased in SG-treated animals (29\u2009\u00b1\u200910%; p\u2009<\u20090.05). In addition, SG improved reperfusion regardless of time of treatment; however, brain injury was smaller only with early treatment in SHR vs. vehicle (28.8\u2009\u00b1\u20093.2% vs. 18.8\u2009\u00b1\u20092.3%; p\u2009<\u20090.05). Limited collateral flow in SHR during MCAO is consistent with small penumbra and large infarction. The ability to increase collateral flow in SHR with SG suggests that this compound may be useful as an adjunct to endovascular therapy and extend the time window for treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24980512,"openaccessinfo":{"externalids":{"MAG":"2609228678","ACL":null,"DOI":"10.1177\/0271678X17705567","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Probing the near-subsurface in the presence of absorbing media is a very challenging problem. Within that framework, we analyse the capabilities of a mono-frequency\/multistatic set-up for detecting shallowly buried targets. As the antennas constitute an important part of the probing device, an accurate method for modelling the antennas behaviour is proposed. This modelling, performed thanks to a correct balanced set of elementary sources, is then incorporated in the calculation of the scattered field, performed with a home-made Finite Element Method software. Efforts have also been put into the measurement procedure. The measured fields are thus post-processed with an efficient method which takes profit of the spectral bandwidth properties of the scattered field. These fields serve as input data for the inversion algorithm, an extension of the DORT method to elongated targets. This qualitative and fast imaging procedure, which exploits the spectral properties of the multistatic scattering matrix, has been adapted to the present stratified configuration. Imaging results of shallowly buried targets embedded in a high losses medium are presented to assess the well-behaviour of the proposed methodology.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128884561,"openaccessinfo":{"externalids":{"MAG":"1998665847","ACL":null,"DOI":"10.3997\/1873-0604.2014046","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the fierce international competition, how to acquire persistent innovation has become a problem to many nations and companies. TRIZ, the theory of inventive problem solving has attracted a wide attention as a powerful theoretical tool to guide innovation which can lead us to break through thought barriers effectively, analyze the problem in a new way and quickly find the solutions to solve the problem . This paper gives a brief review of the development of the TRIZ theory,and focuses on the introduction of TRIZ's inventive problem solving procedures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":64012520,"openaccessinfo":{"externalids":{"MAG":"2348643684","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives To investigate the value of ultrasound (US) and the US-7 score as a screening tool in a population of volunteers visiting the \"Rheuma-Truck\" Methods \"Rheuma-Truck\" was a mobile rheumatology office located in different city center of North Rhine Westphalia offering a screening for rheumatic diseases including Rheuma-Check questionnaire, lab-tests (MCV capillary test), imaging (US, capillaroscopy), and if positive a consultation with a rheumatologist to everybody free of charge. Ultrasound according to US-7 criteria, which is so far only evaluated as a parameter for therapy monitoring, with addition of the MCP-5 joint of the dominant hand of 605 volunteers was performed (MyLab 25 Gold, Esaote linear scanner, 15, Typ LA435). Moreover, in 236 of these volunteers the foot was assessed. Thus a total of 4102 joints were examined by ultrasound. Descriptive statistics for the patients were obtained and are reported as means \u00b1 standard deviation, ranges, frequencies or proportions as appropriate. Correlation coefficients are Pearson-correlations. Results The mean age of the investigated cohort was 52.72 years (min. 10, max. 89 years). Sex distribution shows 72.2% females and 27.8% males. 181 (29.9%) volunteer showed inflammatory signs in ultrasound. Overall MTP-2 was using the US-7 criteria the most frequently involved joint (11.4% B-mode and\/or powerdoppler) followed by the dorsal wrist (8.9%), the MCP-2 (6.6%), PIP-3 (6.0%), PIP-2 (4.3%), the ulnar wrist (3.0%), MCP-3 (2.6%), the palmar wrist (0.5%) and MTP-5 (0.4%). The additionally evaluation of the MCP-5 joint showed with 7.6% the third most pathological findings anyway. Overall 378 volunteers referred a rheumatologist because of pathological findings in Rheuma-Check, lab-tests or ultrasound. 82 of these volunteers were diagnosed as rheumatoid arthritis (13.5%). First evaluations showed high correlations between ultrasound, MCV capillary test and the Rheuma-Check questionnaire. Conclusions Musculoskeletal ultrasound and US-7 scoring system are sufficient screening- and scoring tools for the detection of inflammatory joint alterations in a volunteer cohort. MCP-5 is a frequently involved joint in musculoskeletal ultrasound, which is not included in the US-7 scoring system yet. This study highlights the value of ultrasound in early detection of inflammatory joint diseases in a population of volunteers. Disclosure of Interest None declared DOI 10.1136\/annrheumdis-2014-eular.4228","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":75478597,"openaccessinfo":{"externalids":{"MAG":"2317997668","ACL":null,"DOI":"10.1136\/annrheumdis-2014-eular.4228","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The interaction of lanthanides and trivalent actinides with borate in dilute to concentrated alkaline NaCl, MgCl2 and CaCl2 solutions was investigated at 22 \u00b1 2 \u00b0C by a comprehensive series of solubility experiments with Nd(OH)3(am), and complemented with Cm(III)\u2013TRLFS studies (TRLFS: time resolved laser fluorescence spectroscopy) under analogous pH and ionic strength conditions. Although there was clear evidence of borate complexation in the pH range of 8.5 to 10, overall no significant increase in Nd(III) solubility occurred in any of the investigated salt systems in the presence of [B]tot \u2264 0.4 M, compared with analogous borate-free solutions. On the contrary, a significant decrease in Nd(III) concentration was observed at pHc \u2264 9 in NaCl and MgCl2 systems with [B]tot \u2265 0.16 M (diluted salt systems) or [B]tot \u2265 0.04 M (concentrated salt systems). This observation, together with a clear change in the slope of the solubility curve and the further confirmation by XPS analyses, indicates the transformation of Nd(OH)3(am) into a so far unknown Nd(III)\u2013borate solid phase with significantly lower solubility. Similar Nd(III) concentrations in the aqueous phase are obtained in undersaturation solubility experiments conducted with a synthesized crystalline phase Nd[B9O13(OH)4](cr). TRLFS confirmed the formation of aqueous Cm(III)\u2013borate complexes in dilute to concentrated NaCl and MgCl2 systems at pHc = 8 and [B]tot \u2265 0.04 M. Two different Cm(III)\u2013borate species are proposed based on the peak shift of the spectra, although the resulting fluorescence emission bands do not allow the definition of an unequivocal chemical model for this system. TRLFS also shows that no Cm(III)\u2013borate complexes form under hyperalkaline conditions (pHc = 12), due to the stronger competition posed by hydrolysis and the predominance of weakly coordinating B(OH)4\u2212 in the aqueous phase. These results show the impact of An(III)\u2013borate interactions on An(III) speciation and highlight the hitherto unknown role of borate in the immobilization of trivalent actinides under repository-relevant conditions due to the formation of borate-bearing solid phases with significantly lower solubility than the corresponding hydroxides.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":96097561,"openaccessinfo":{"externalids":{"MAG":"2012195683","ACL":null,"DOI":"10.1039\/C4NJ01203H","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"................................................................................................................................................. ii Preface ................................................................................................................................................... iv Table of contents.................................................................................................................................... vi List of tables ............................................................................................................................................ x List of figures .......................................................................................................................................... xi List of abbreviations .............................................................................................................................. xvi Acknowledgements ................................................................................................................................xx","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88109326,"openaccessinfo":{"externalids":{"MAG":"2310092718","ACL":null,"DOI":"10.14288\/1.0167619","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work attempts to establish the age and chronologic sequence of mid-Cenozoic tectonic events in Trans-Pecos Texas through the use of radiometric dates, and new or revised structural, lithostratigraphic, and vertebrate biostratigraphic information. Late Mesozoic to early Cenozoic Laramide faulting, folding, and jointing superimposed on older trends, established the fabric governing younger structures. Late Oligocene events, occurring about 28 to 26 m.y.B.P., include right-lateral divergent wrench faulting, local compression, and the last episodes of silicic intrusion-extrusion. The major period of basin-and-range faulting began about 19 m.y.B.P., accompanied by late and mafic minor intrusion. This paper follows the sequence of tectonic events established by Muehlberger in 1980 and DeCamp in 1981 for Trans-Pecos Texas. A widespread low relief surface was cut across Laramide structures as deformation decreased in the Eocene. Integrated, perennial streams flowing southeastward began extensive laterally continuous aggradation in the area south and southwest of the stable Diablo uplift. Mainly fine, volcaniclastic sediments accumulated on surfaces of continued low relief. Initially, sediment sources were distant but became progressively more local. Episodic ignimbrites and flows covered large areas with increasing frequency. Eocene climate in Trans-Pecos Texas was humid and subtropical, but an irregular trend toward increasing dryness was evident by 31 m.y.B.P. Sedimentary bodies younger than middle Oligocene have little lateral continuity. Deposited under semiarid conditions, as destructional volcanic sediment aprons, alluvial fans, or bolson fills, these units show progressive divergence from depositional styles of early Tertiary sediments. Early Arikareean (early late Oligocene) right-lateral divergent wrench faulting interrupted long-established drainage patterns. The faulting, dated by intrusions and biostratigraphy at about 28 to 26 m.y.B.P., closed the interval of laterally continuous, and preceded that of discontinuous, deposition. The irregular Terlingua monocline, long considered a Laramide structure, is re-interpreted as another example of Trans-Pecos Texas linear east-west tectonic elements discussed by Dickerson in 1981. The str cture is a large monocline cut by a set of an echelon-left normal faults and smaller monoclines, modified by compression. Formation of the large monocline involved rocks as young as late Eocene-early Oligocene. The Terlingua monocline provides clear evidence of the sequence of events and some indication of timing. Later Arikareean sediments lie on uneven eroded older rocks, disturbed by early stages of this wrench faulting. About 23 m.y.B.P. downfaulted basins began to retain bolson\/alluvial fan sediments. Deposition may have resulted from progressive deformation of the change to mafic volcanism. Increasing aridity may also have been a factor. Basin-and-range faulting affected Trans-Pecos Texas during the Hemingfordian (early Miocene), and continues. This tectonism faulted the later Arikareean-Hemingfordian alluvium by reactivating old faults and creating new ones. Basin-and-range faulting shifted, deepened, and more completely restricted basins of deposition by forming a series of northwest oriented grabens which received great thickness of later Miocene and younger alluvium. (See Figure on page 615). End_of_Article - Last_Page 552------------","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129649528,"openaccessinfo":{"externalids":{"MAG":"2032276986","ACL":null,"DOI":"10.1306\/03B5B51A-16D1-11D7-8645000102C1865D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Oxidative reactions of VX type compounds and N,N-dialkylaminoethane-2-thiols that are precursors for VX compounds produce N,N-dialkylaminoethane-2-sulphonic acids, N(R(1))(R(2))-CH(2)-CH(2)SO(3)H (where R(1) and R(2) = methyl, ethyl, n-propyl and isopropyl, 1-10), as the degradation products, and these degradation products are considered as markers for the detection of chemicals listed in the schedules of Chemical Weapons Convention (CWC) chemicals. Off-site detection of such degradation products in aqueous samples is an important task in the verification of CWC-related chemicals. Here we report a simple method involving the direct analysis of aqueous samples using positive and\/or negative ion electrospray ionization (ESI) for the screening, detection and identification of N,N-dialkylaminoethane-2-sulphonic acids, avoiding sample preparation and chromatographic steps. The positive ion ESI mass spectra of all the compounds result in abundant [M+Na](+) ions, and the negative ion spectra show abundant [M-H](-) ions to confirm their molecular weight. The collision-induced dissociation spectra of [M+Na](+) and [M-H](-) give characteristic product ions by which it is easy to detect and identify all the studied N,N-dialkylaminoethane-2-sulphonic acids including those of isomeric compounds. The method is successfully applied to detect the spiked chemical, N,N-diisopropylaminoethane-2-sulphonic acid, present in a water sample received in a proficiency test.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20250307,"openaccessinfo":{"externalids":{"MAG":"2092395194","ACL":null,"DOI":"10.1002\/RCM.3300","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Reversible data hiding in encrypted images (RDHEI) consists of embedding data in the encrypted domain. In current state-of-the-art methods, most of them use least significant bit (LSB) substitution or prediction, but fail to embed a significant amount of information. Recently, a new class of RDHEI method, based on most significant bit (MSB) substitution, has emerged. By exploiting the natural correlation between pixels in the clear domain, it is possible to have a payload close to 1 bpp with a very high image quality, without adding overhead. In particular, in the approach based on embedded prediction errors (EPE-based approach) [6], the authors propose to embed the prediction error location information in the encrypted MSB-plane. In this paper, we present a huge-capacity RDHEI (HCRDHEI) method. In fact, we are interested in improving the proposed EPE-based RDHEI approach by using recursively other bit-planes, from MSB to LSB as long as it is possible. Indeed, depending on the image content, bit-planes can easily be predicted, and so most of them can be substituted by bits of a secret message. According to the obtained results, the payload can be much higher than 1 bpp (median equal to 1.749 bpp, on average 1.836 bpp, and 5.408 bpp in the best case), while preserving perfect reversibility.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2024-26":1,"2024-10":1,"2024-30":1}},"corpusid":59554147,"openaccessinfo":{"externalids":{"MAG":"2912379265","ACL":null,"DOI":"10.1109\/WIFS.2018.8630788","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper introduces gMig, an open-source and practical GPU live migration solution for full virtualization. By taking advantage of the dirty pattern of GPU workloads, gMig presents the One-Shot Pre-Copy combined with the hashing based Software Dirty Page technique to achieve efficient GPU live migration. Particularly, we propose three approaches for gMig: 1) Dynamic Graphics Address Remapping, which parses and manipulates GPU commands to adjust the address mapping to adapt to a different environment after migration, 2) Software Dirty Page, which utilizes a hashing based approach to detect page modification, overcomes the commodity GPU's hardware limitation, and speeds up the migration by only sending the dirtied pages, 3) One-Shot Pre-Copy, which greatly reduces the rounds of pre-copy of graphics memory. Our evaluation shows that gMig achieves GPU live migration with an average downtime of 302 ms on Windows and 119 ms on Linux. With the help of Software Dirty Page, the number of GPU pages transferred during the downtime is effectively reduced by 80.0%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":239592414,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1145\/3296975.3186414","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nUstekinumab was recently approved for the treatment of moderate to severe Crohn's disease (CD). Although the ustekinumab Clinical Decision Support Tool (UST-CDST) was able to predict ustekinumab responsiveness in a clinical trial, it is not clear whether UST-CDST can also predict a future clinical relapse following ustekinumab therapy in the real-life setting.\n\n\nMETHODS\nWe enrolled patients with moderate to severe CD who were refractory to conventional therapies and who showed a clinical response after induction therapy with ustekinumab and monitored them until the relapse. We performed a Cox proportional hazard analysis to investigate the predictive capability of UST-CDST for a clinical disease relapse.\n\n\nRESULTS\nClinical remission rates at week 20 were 25.0% for low-probability responders, 66.7% for intermediate-probability responders, and 75.0% for high-probability responders. The high-probability responders were more likely to achieve clinical remission at week 20 compared with the low-probability responders. Among 99 patients with moderate to severe CD, 37 (37.4%) experienced a clinical relapse during the median follow-up period of 18.0 months of ustekinumab treatment. The cumulative relapse rates were 70.0% in the low-probability responders, 35.9% in the intermediate-probability responders, and 22.5% in the high-probability responders (P\u2005=\u2005.001). In a multivariable Cox proportional hazard analysis, the high-probability responders and intermediate-probability responders had a lower risk of clinical relapse than the low-probability responders. Receiver operating characteristic analysis using UST-CDST to predict relapse revealed an area under the curve of 0.698.\n\n\nCONCLUSIONS\nThe UST-CDST can predict clinical relapse in patients with moderate to severe CD subjected to ustekinumab therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249432792,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/ibd\/izac105","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the field of education, information and communication technologies and multimedia tools have become more prevalent then ever that almost all schools can obtain. Physical education which is not only very important component of formal and informal education but also an important part of lifelong learning has been affected by these developments and physical education teachers has begun to use educational technologies and multimedia. On the other hand, because of some reasons like lack of technical facilities and inadequate in-service training, educational technologies and multimedia tools are either not used in physical education classes or used ineffectively. In this study, how often and which educational technologies and multimedia tools are used by physical education teachers and \u2013 if there are \u2013 the reasons for ineffective use of these tools are investigated. Moreover, based on the findings of the study, some suggestions for physical education teachers to use educational technologies better are made.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":61492096,"openaccessinfo":{"externalids":{"MAG":"2154515663","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As is now well known, the very varied symptoms produced by rapid decompression from high atmospheric pressures, and popularly known as \" caisson disease\" or \" diver's palsy,\" are due to liberation of bubbles of gas\u2014chiefly nitrogen\u2014in the blood and tissues. In the course of a recently published investigation, I found that air is much more soluble in certain oils than in water. Dr. J. S. Haldane pointed out to me the interest of this fact in connection with the causation of caisson disease, and at his suggestion I have repeated and extended my observations. The fats experimented with were olive oil, cod liver oil and lard. In the case of the first two, the solubility was measured at 15\u00b0 and at 37\u00b0 C., whilst for lard it was determined at 45\u00b0 C. In the observations made at room temperature, the oil was shaken violently with air in a bottle for several minutes, and was allowed to stand for 1 to 1\u00bd hours till all the air bubbles had risen to the surface. It was then weighed, and about 40 to 50 grammes of it were sucked up into the vacuous flask of a Geissler's mercury pump. This flask contained 70 to 100 c. c. of 0\u00b75 per cent, sulphuric acid which had previously been well boiled for an hour so as to get rid of all traces of air. The mixture of oil and water was now boiled for half an hour, the oil breaking up into a very fine emulsion and giving up practically all of its gas in the first few minutes. This gas was pumped off and analysed with Haldane's gas analysis apparatus. The oil was boiled with dilute acid instead of water, so as to obtain the whole of the carbon dioxide present, both combined and in solution. In determining the solubility at 37\u00b0, the oil, previously saturated at room temperature, was warmed to about 38\u00b0 to 39\u00b0, and was shaken vigorously with air for about two minutes. At the end of this time its temperature had fallen to about 36\u00b0\u00b75. It was warmed up a second time and the shaking repeated, and was then kept in a water bath at 37\u00b0 for about half an hour in the case of the cod liver oil, and an hour in the case of the olive oil, these being the times required for all the bubbles of air to rise to the surface. The gaseous content of a weighed amount of the oil was then determined as before. The results obtained are given in the tables. They represent the volumes of gas, reduced to 0\u00b0 and 760 mm., contained in 100 c. c. of the oil at the temperature recbrded, when saturated with air at a pressure of 760 mm. To calculate these values, it was assumed that the specific gravity of olive oil at 15\u00b0 is 0\u00b7917, and at 37\u00b0, 0\u00b7902. The specific gravity of cod liver oil, compared with that of water at 15\u00b0, was found by direct experiment to be 0\u00b7928 at 15\u00b0, and 0*914 at 37\u00b0.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":98570296,"openaccessinfo":{"externalids":{"MAG":"2051892531","ACL":null,"DOI":"10.1098\/rspb.1907.0029","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/rspb.royalsocietypublishing.org\/content\/79\/533\/366.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We demonstrate a three-wavelength, time-synchronized, ultrashort (\u223c90 fs), energetic (\u223c6.5 nJ) pulse source from a single fiber aperture, uniquely enabled by the recently discovered process of soliton self-mode conversion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221718524,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: To investigate the sensitivity and specificity of confocal corneal microscopy (CCM) in the diagnosis of immune-related motor neuron disease syndrome and evaluation of the response to immunosuppressive therapy. Methods: Seventy-two patients with clinical manifestations of motor neuron disease (MND) were analysed. According to whether they had concomitant rheumatic immune disease or rheumatic immune antibody abnormalities, they were divided into an MND group (33 patients) and an immune-related MND syndrome group (39 patients). Another 10 healthy adults were selected as the control group. All individuals were examined by CCM. Results: For Langerhans cell density (LCD), the area under the ROC curve was 0.8, the best cut-off was 67.7 cells\/mm2, the sensitivity was 79.5%, and the specificity was 72.7%. For inferior whorl length (IWL), the area under the ROC curve was 0.674, the best cut-off was 17.41 mm\/mm2, the sensitivity was 69.2%, and the specificity was 66.7%. After immunosuppressive therapy in 5 patients with immune-related MND syndrome, the LCD was significantly reduced (P<0.05), and there was no statistically significant change in the IWL (P>0.05). Conclusion: The LCD and IWL are ideal for distinguishing MND from immune-related MND syndrome. The LCD reflects immunotherapy response sensitively.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":246318029,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-1210113\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-1210113\/latest.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The double-chained cationic surfactant didodecyldimethylammonium bromide (DDAB) was found to form more stable coatings onto the walls of CE capillaries than similar single-chained surfactants such as cetyltrimethylammonium bromide (C16TAB). After removing DDAB from the buffer, the reversed EOF decreased only 3% over 75 min under continuous electrophoretic conditions. Also, the reversed EOF is 60% greater for DDAB than for C16TAB at pH 2. This greater coating stability is associated with a different aggregate structure for the surfactant at the capillary surface. The more homogeneous coating and greater surface coverage provided by DDAB allows the excess surfactant to be flushed from the capillary prior to performing electrophoretic separations. Separations of a basic protein mixture yielded quantitative recoveries, efficiencies ranging from 560,000 to 750,000 plates\/m, and migration time reproducibility of 0.8-1.0% RSD (n = 10). This performance is similar to that of adsorbed cationic polymers (Polybrene, polyethyleneimine) but is achieved using a coating procedure that is over 10 times faster.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1351935,"openaccessinfo":{"externalids":{"MAG":"1972975780","ACL":null,"DOI":"10.1021\/AC000335Z","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rapid laser annealing of a Cu(In,Ga)Se2 (CIGS) thin film absorber was proposed and demonstrated using a continuous 532-nm Nd:YAG laser, following sputtering with Cu0.9In0.7Ga0.3Se2 target, because the conventional annealing temperature for improving the crystallinity of CIGS thin films is higher than the decomposition temperature of a typical flexible polymer substrate. When the laser optical power was incrementally increased over the range from 2.00 to 3.00 W, for 200 s, XRD patterns showed the formation of CIGS chalcopyrite (112), (220\/204), and (312\/116) phases in the laser-annealed CIGS thin films, at laser optical powers of 2.75 and 3.00 W. The band gaps of these laser-annealed CIGS thin films varied from 1.45 to 1.83 eV and depended on the laser optical power. The relative mean absorbance of the laser-annealed CIGS thin films was 1.806, suggesting that approximately 98.44% of the incident photons were observed by the 600-nm-thick film in the visible spectral region. Conductivity type varied with changes in the laser optical power. The resistivities of the laser-annealed CIGS thin films were of order of 10\u22123 - 101 \u03a9-cm.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256336162,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3938\/jkps.70.809","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Drug-eluting bead transarterial chemoembolization (DEB-TACE) is a relative new endovascular treatment based on the use of microspheres to release chemotherapeutic agents within a target lesion with controlled pharmacokinetics. This aspect justifies the immediate success of DEB-TACE, that nowadays represents one of the most used treatments for unresectable hepatocellular carcinoma. However, there is no consensus about the choice of the best embolotherapy technique. In this review, we describe the available microspheres and report the results of the main comparative studies, to clarify the role of DEB-TACE in the hepatocellular carcinoma management. We underline that there is no evidence about the superiority of DEB-TACE over conventional TACE in terms of efficacy, but there may be some benefits with respect to safety especially with the improvement of new technologies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":51605803,"openaccessinfo":{"externalids":{"MAG":"2827438165","ACL":null,"DOI":"10.2217\/fon-2018-0136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Serotonin immunoreactive fibers were observed under the electron microscopy in all layers of the small intestine, with greatest abundance in the mucosa. Submucosal blood vessels were often surrounded by immuno positive nerves. In the inner circular muscle layer the immunoreactive serotonin positive fibers were closely associated with the smooth muscle cells. In the ganglia of the myenteric and submucous plexuses, labelled fibers surrounded the immunonegative neural cell bodies, but rarely formed conventional synaptic junctions. It is concluded that the serotoninergic system of the small intestine may influence the activity of associated structures in a diffuse non-synaptic manner.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25826356,"openaccessinfo":{"externalids":{"MAG":"2465896828","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Clusters heavier than those observed in the cluster-radioactivity of heavy nuclei can not only be formed in superheavy compound nuclei but also be immediately expelled, because the clusterization energy is very great. This process differs from cluster-radioactivity and constitutes a new type of fission reaction. Its reality is confirmed by recent experimental observations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123499217,"openaccessinfo":{"externalids":{"MAG":"2078606441","ACL":null,"DOI":"10.1209\/EPL\/I2002-00647-9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study finite impulse response (FIR) multi-input multi-output (MIMO) systems with additive noise, treating the finite- length sources and channel coefficients as deterministic unknowns, considering both regularity and identifiability. In blind estimation, the ambiguity set is large, admitting linear combinations of the sources. We show that the Fisher information matrix (FIM) is always rank deficient by at least the number of sources squared and develop necessary and sufficient conditions for the FIM to achieve its minimum nullity. Tight bounds are given on the required source data lengths to achieve minimum nullity of the FIM. We consider combinations of constraints that lead to regularity (i.e., to a full-rank FIM and, thus, a meaningful Cram??r-Rao bound). Exploiting the null space ofthe FIM, we show how parameters must be specified to obtain a full-rank FIM, with implications for training sequence design in multisource systems. Together with constrained Cram??r-Rao bounds (CRBs), this approach provides practical techniques for obtaining appropriate MIMO CRBs for many cases. Necessary and sufficient conditions are also developed for strict identifiability (ID). The conditions for strict ID are shown to be nearly equivalent to those for the FIM nullity to be minimized.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120287805,"openaccessinfo":{"externalids":{"MAG":"1883803668","ACL":null,"DOI":"10.1109\/9780470544198.CH38","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Innovative firms rely increasingly on academic science, yet they exploit only a small fraction of all academic discoveries. Which discoveries in academia do firms build upon? We posit that hubs play the role of bridges between academic science and corporate technology. Tracking citations from patents to approximately 10 million academic articles, we find that hubs facilitate the flow of academic science into corporate inventions in two ways. First, hub-based discoveries in academia are of higher quality and are more applied. Second, firms\u2014in particular young, innovative, science-oriented ones\u2014pay disproportionate attention to hub-based discoveries. We address concerns regarding unobserved heterogeneity by confirming the role of firms' attention to hub-based science in a set of 147 simultaneous discoveries. Importantly, hubs not only facilitate localized knowledge flow but also extend the geographic reach of academic science, attracting the attention of distant firms. This paper was accepted by Ashish Arora, entrepreneurship and innovation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":211300025,"openaccessinfo":{"externalids":{"MAG":"2912980833","ACL":null,"DOI":"10.2139\/ssrn.3006859","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background Our Public Healthcare Service have developed some quality indicators (QI) based on the selection of drugs that support better evidence of efficiency in areas of prescribing where more deviations were detected in the past. Purpose To describe the strategies for improving the indicators, measuring compliance with them after three years and evaluating their financial impact on the public budget. Material and methods Retrospective observational study. The percentage of prescriptions of three QIs (omeprazole versus total PPIs, simvastatin versus total lipid-lowering drugs and ACE inhibitors versus total renin-angiotensin-aldosterone-system inhibitors) was evaluated before and after an educational program consisting of clinical sessions, meetings with the head of medical team (HMT) and Medical Director, periodic written reports for doctors and interviews with low-compliance-rate doctors. Prescription rates were measured in March 2011 and February 2014. Prescribing data and financial impact were obtained from the reimbursed drugs Program (Microstrategy), which enabled us to calculate the possible savings if the optimal level of prescriptions were to be reached. Results 24 clinical sessions were held in 2011, 17 in 2012 and 10 in 2013. Meetings with the HMT and Medical Director were biannual in 2011 and annual in 2012\u201313. 23 interviews were held, all in 2013. Reports were distributed in 100% of Units and possible periods. Omeprazole prescription was 69.3% at the beginning and increased to 85.4% three years later. Simvastatin prescribing also increased from 18.07% to 40.4%, and the percentage of ACE inhibitors rose from 28.44% to 52.82%. Regarding cost savings, in March 2011 drug expenditure in our Healthcare Area was \u20ac244, 717 more than with the theoretical optimum level of prescription, but in February 2014, this excess had reduced to just \u20ac44,803. Conclusion The strategies adopted were well received by the doctors, resulting in a considerable improvement of the indicators evaluated. This improvement now produces direct annual savings of \u20ac200,000 in the public budget in our Healthcare Area compared to three years ago. References and\/or acknowledgements No conflict of interest.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":71686561,"openaccessinfo":{"externalids":{"MAG":"1978304522","ACL":null,"DOI":"10.1136\/ejhpharm-2015-000639.199","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The processes leading to dust formation and the subsequent role it plays in driving mass loss in cool evolved stars is an area of intense study. Here we present high resolution ALMA Science Verification data of the continuum emission around the highly evolved oxygen-rich red supergiant VY CMa. These data enable us to study the dust in its inner circumstellar environment at a spatial resolution of 129 mas at 321 GHz and 59 mas at 658 GHz, thus allowing us to trace dust on spatial scales down to 11 R (71 AU). Two prominent dust components are detected and resolved. The brightest dust component, C, is located 334 mas (61 R ) southeast of the star and has a dust mass of at least 2.5 \u00d7 10\u22124 M . It has a dust emissivity spectral index of \u03b2 = \u22120.1 at its peak, implying that it is optically thick at these frequencies with a cool core of Td <\u223c 100 K. Interestingly, not a single molecule in the ALMA data has emission close to the peak of this massive dust clump. The other main dust component, VY, is located at the position of the star and contains a total dust mass of 4.0 \u00d7 10\u22125 M . It also contains a weaker dust feature extending over 60 R to the north with the total component having a typical dust emissivity spectral index of \u03b2 = 0.7. We find that at least 17% of the dust mass around VY CMa is located in clumps ejected within a more quiescent roughly spherical stellar wind, with a quiescent dust mass loss rate of 5 \u00d7 10\u22126 M yr\u22121. The anisotropic morphology of the dust indicates a continuous, directed mass loss over a few decades, suggesting that this mass loss cannot be driven by large convection cells alone.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":839090,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The differences in terms of access and ICT skills between different groups in society have created a problem of digital divide. To overcome this problem, models and strategies are required to achieve a greater impact on the population and that population can develop skills that enhance inclusion in the society knowledge. This work proposes a service-oriented architecture of digital literacy under the Ecosystem Approach that aims to set a new educational paradigm approach to encourage different learning communities to uses new ICT that allows them to be more competitive in today's world and thus shorten the digital divide. Finally, a case study is shown as an implementation of the model in a learning community of librarians in the state of Aguascalientes, M\u00e9xico.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30199255,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/tla.2016.7530433","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The Unmanned Aerial Vehicle (UAV) is controlled remotely by the operator at the Ground Control Station (GCS) during the mission. Reliable electrical energy is needed to supply energy needs in GCS, such as radio communications, workstations, weather stations, HVAC systems, and lamps when the UAV is operating. GCS is located in Ranai City, Natuna Islands. The UAV mission in Ranai can assist the military in monitoring border surveillance, disaster management, and mapping the area. GCS power source in the initial design, using a diesel generator as the main power source with a power of 12 kW for 192.3 kWh per day energy consumption and 10.8 kW load peak. This paper has shown the study on a hybrid system with 3 scenarios, consisting of a PV system, wind turbine, generator, and battery. The system is simulated by using HOMER for accounting the technical and economic aspects. The results showed that the NPC and LCOE of the third scenario, which consisted of PV\/wind\/battery, were $181,157.38 and $0.15 per kWh, respectively. It has the lowest cost compared to the first scenario with the usage of diesel generator only. The average fuel consumption is 7.97 litre per day, down 87% compared to the existing condition. Thus, this configuration can overcome the costs of delivering fuel supplies for GCS operations and complement the government's efforts to achieve emission reduction targets.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":255150755,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1755-1315\/1121\/1\/012009","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1755-1315\/1121\/1\/012009\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair\/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231720802,"openaccessinfo":{"externalids":{"MAG":"3119029586","ACL":null,"DOI":"10.1155\/2021\/8834590","PubMedCentral":"7806381","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/sci\/2021\/8834590.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The association of COP9 signalosome (CSN) with Constitutive Photomorphogenic 1 (COP1) was characterized in plants for a role in photomorpho-genesis. However, since mammalian cells do not perform photomorphogenesis, roles of these two proteins remain enigmatic. Recently we began to unravel their roles in oncogenesis. \n \nThe CSN is an evolutionarily conserved multiprotein complex. Mammalian CSN consists of eight subunits (CSN1-CSN8) and has diverse functions, including cell cycle control, signal transduction, and tumorigenesis. Interestingly, CSN6, which is involved in stabilizing MDM2 [1] and preserving Cullin neddylation [2], is overexpressed in many types of cancers, implying its oncogenic role in cancer. However, the mechanistic regulation and biological consequence of CSN6 overexpression in cancer remain to be examined. Mammalian COP1 is an evolutionarily conserved E3 ubiquitin ligase, which contains RING-finger, coiled-coil and WD40-repeat domains. Through association with the CSN, COP1 functions as a crucial mediator to block photomorphogenesis in the dark through regulating the ubiquitinated proteasomal degradation of light-induced transcription factor HY5. In mammalian cells, COP1 is overexpressed in a various types of cancers, and it causes ubiquitin-mediated degradation of tumor suppressor p53, suggesting its oncogenic role in cancer. But its other substrates through protein degradation may have roles in tumorigenesis. \n \nRecently, CSN6's interaction with COP1 is characterized in mammalian cells, and CSN6-COP1 axis is involved in 14-3-3\u03c3 degradation [3]. COP1 is an E3 ligase of 14-3-3\u03c3. 14-3-3\u03c3, a tumor suppressor involved in opposing cancer metabolic reprogramming [4] and Akt signaling, is known to be upregulated by p53 and has a positive feedback effect on p53 in response to DNA damage. CSN6 stabilizes COP1 through reducing COP1 self-ubiquitination and thus decelerates COP1's turnover rate. CSN6\/COP1-mediated 14-3-3\u03c3 ubiquitination is compromised when COP1 is knocked down. Subsequently, CSN6-COP1 axis causes 14-3-3\u03c3 downregulation, thereby activating Akt and promoting cancer cell survival. \n \nAlso, the CSN6-COP1 axis regulates the stability p27Kip1, a critical G1 CDK inhibitor involved in cell cycle brake. COP1 is an E3 ligase of p27 to enhance p27 ubiquitination and subsequent degradation, which acts independent of negative regulators (E3 ligases) of p27, such as SKP2, Jab1, Pirh2, or KPC1 [5, 6]. Ectopic expression of CSN6 decreases the expression of p27 while CSN6 knockdown leads to p27 stabilization. Mechanistic studies show that CSN6 interacts with p27 and facilitates ubiquitin-mediated degradation of p27. CSN6-mediated p27 degradation depends on the nuclear export of p27, which is regulated through COP1's nuclear exporting signal. COP1 overexpression leads to the cytoplasmic distribution of p27, thereby accelerating p27 degradation. Importantly, the negative impact of COP1 on p27 stability contributes to elevated expression of genes that are suppressed through p27 mediation. Also, COP1-mediated p27 translocation to the cytoplasm will promote cancer cell migration and invasiveness, phenomena imposed by p27 cytoplasmic distribution. Kaplan-Meier analysis of tumor samples demonstrates that high COP1 or CSN6 expression is correlated with poor overall survival. These data suggest that tumors with CSN6-COP1 axis activation may have growth advantage by regulating p27 degradation and by subsequently impacting on p27 targeted gene expression. \n \nUnderstanding the genome integrity and DNA damage response is critical to cancer treatment. CSN6-COP1 axis can regulate genome integrity [7]. CSN6 overexpression leads to mitotic defect and ROS production. Importantly, COP1 and Aurora A (a p27-mediated suppressed gene involved in mitosis) are involved in this process. p27 levels are elevated after DNA damage, with concurrent reduction of COP1 levels. Mechanistic studies demonstrate that during DNA damage response COP1's function as an E3 ligase of p27 is inactivated due to 14-3-3\u03c3-enhanced COP1 degradation, thereby reducing the ubiquitin-mediated degradation of p27. This process of p27 accumulation in response to DNA damage is not p53-dependent, but it is ATM- and 14-3-3\u03c3-dependent. 14-3-3\u03c3 collaborates with ATM activity to mediate downregulation of COP1 after DNA damage. Congruently, in 14-3-3\u03c3-null cells, COP1 is not downregulated by DNA damage; therefore, p27 levels are not increased. Expression of 14-3-3\u03c3 facilitates the downregulation of COP1 and subsequent increase of p27 in response to DNA damage. Studies show that p27 levels accumulate in the nucleus when COP1 is excluded from the cytoplasm in the presence of the DNA-damaging agent doxorubicin, suggesting that DNA damage affects the subcellular distribution of COP1, which in turn affects p27 levels. Further, COP1 overexpression leads to downregulation of p27Kip1, thereby promoting the overexpression of Aurora A, which correlates with poor survival. These findings provide new insight into CSN6-COP1-p27-Aurora A axis in DNA damage repair and tumorigenesis. \n \nTaken together, data show that COP1 is critical in CSN6-mediated oncogenesis, conferring impacts on 14-3-3\u03c3, p27, Aurora A, Akt, metabolic reprogramming, genome integrity, and others. Further studies should be explored to address the following questions. What are other downstream ubiquitination targets of CSN6-COP1 axis involved in cancer? What are the upstream oncogenic signals in regulating this axis to promote cancer growth? Strategy in hindering the CSN6-COP1 axis activation may be a useful therapeutic strategy for cancer intervention.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15131253,"openaccessinfo":{"externalids":{"MAG":"2317908852","ACL":null,"DOI":"10.18632\/AGING.100778","PubMedCentral":"4543032","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A general model for pressure drop calculations in siphons and riser tubes has been developed. The model takes into account different physical flow phenomena such as the inlet pressure drop and the pressure drop in the tube. For each phenomenon, we applied theory and established correlations to calculate the separate accelerational, frictional, gravitational, and centrifugal pressure drops. Model results agree closely with experimental data for the flow of air and water, without the need to fit any empirical constants. The minimum in the pressure drop curve is accurately predicted.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110642241,"openaccessinfo":{"externalids":{"MAG":"2168603540","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work aimed to analyze the poem \"A Folha\", by Carlos Drummond de Andrade, seeking to identify the ideas of nature that can be enunciated in a Biology teacher training environment. For this, we resorted to Discourse Analysis, using the Bakhtin Circle as a theoretical-methodological framework. From the analysis, it was possible to see that the poem raises dialogues that permeate different ideas of a historically constructed nature, based on the ideas of Plato, Kant, Hegel and Marx and Engels. Furthermore, the analysis of the poem reminds us of the importance of such discussions for teacher education.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245525386,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17271\/1980082717520213058","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.17271\/1980082717520213058","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Gastric mantle cell lymphoma is a rare form of gastrointestinal tumor and represents 2.5\u20137% of all non-Hodgkin's lymphomas. A 69-year-old maleadmitted with spontaneous pneumothorax was found to have a gastric masson CT scan. Results of histopathological,immunohistochemical and genetic analysis were consistent with mantle cell lymphoma(MCL).Patient responded well to intensive chemotherapy and subsequent allogeneic hematopoietic stem cell transplant and remains in complete remission.We would like to emphasize that a gastric mass, as in this case can occur as a rare presentation of MCL involving the gastrointestinal tract without any other overt signs and symptoms. Journal of Advances in Internal Medicine 2013;02(01):24-26 DOI: http:\/\/dx.doi.org\/10.3126\/jaim.v2i1.7635","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":43421195,"openaccessinfo":{"externalids":{"MAG":"2094810171","ACL":null,"DOI":"10.3126\/JAIM.V2I1.7635","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report a detailed first-principles local-density-functional investigation of the structural, electronic, dynamical and superconducting properties of MgB2 focusing on different aspects related to this material. In particular, we examine Al doping, as well as reduced dimensionality and pressure effects on the electronic and superconducting properties of this compound. Our ab initio calculations for the case of 50% Al doping are able to correctly reproduce the measured frequencies of the E2g phonon and explain the disappearance of superconductivity in terms of filling effects on both carrier concentration and electron\u2013phonon coupling. The surface study shows that an enhanced density of states at the Fermi level is found in the B-terminated case. However, we find the Mg-terminated surface to be the most stable structure in the whole range admitted by the chemical potentials, in agreement with very recent experimental results. Finally, the study of the E2g phonon frequency under pressure is able to explain the critical temperature lowering under applied pressure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121659003,"openaccessinfo":{"externalids":{"MAG":"2049034340","ACL":null,"DOI":"10.1088\/0953-2048\/16\/2\/301","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Research efforts have been devoted to evaluating the application of the chitosan (CS)\/glycerol-\u03b2-phosphate (GP) disodium salt hydrogel in peripheral nerve regeneration. The gelation time was determined to be 770 s using ultraviolet spectrophotometry. A standard 10 mm long rat sciatic nerve defect model was employed, followed by bridging the proximal and distal stumps with chitosan conduits injected with the Schwann cell-containing hydrogel. Injections of the blank hydrogel, Schwann cell suspension and culture medium were used as controls. Two months later, electrophysiological assessment and fluorogold retrograde tracing showed that compound muscle action potentials (CMAPs) and fluorogold-labeled neurons were only detected in the Schwann cell suspension group and culture medium group. The rats were then killed, and implanted conduits were removed for examination. There were no regenerated nerves found in groups injected with the blank hydrogel or Schwann cell-containing hydrogel, while the other two groups clearly displayed regenerated nerves across the gaps. In the subsequent histological assessment, immunohistochemistry, toluidine blue staining and transmission electron microscopy were performed to evaluate the regenerated nerves. The relative wet weight ratio, Masson trichrome staining and acetylcholinesterase staining were employed for the examination of gastrocnemius muscles in all four groups. The Schwann cell suspension group showed the best results for all these indexes; the culture medium group ranked second and the two hydrogel-injected groups showed the least optimal results. In conclusion, our data revealed that the implanted CS\/GP hydrogel actually impeded nerve regeneration, which is inconsistent with former in vitro reports and general supposition. We believe that the application of the CS\/GP hydrogel in nerve regeneration requires a further study before a satisfactory result is obtained. In addition, the present study also confirmed that Schwann cell implantation stimulated nerve regeneration.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28413049,"openaccessinfo":{"externalids":{"MAG":"1994143478","ACL":null,"DOI":"10.1088\/1748-6041\/5\/3\/035003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":". The article is devoted to the study of matters in solving applied tasks in computer science by using methods of mathematical and computer modeling. These methods allow to create an innovative approach to solving research tasks that are the basis for the development of key competencies of the future teacher of computer science. The article provides an example of building a model of \"predator\"-\"prey\", which includes: a general description of the model, stating the problem, compilation of a mathematical model for dealing with the task, transferring a mathematical model into a computer one. Modeling in the field of dealing with applied tasks is actively used while teaching students at Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shanskiy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249280833,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A clinical case of herpetic manifestation in the mouth is described as a grave gingivostomatitis in a child aged 12. Chronology and symptomatics of the disease are analyzed in details as well as the difficulties both in diagnostics and treatment. Some important moments are discussed that usually aggravate the clinical picture and the treatment of similar conditions--including an antibiotic from penivillin group in the treatment, the presence of cutting teeth with inflammatory alterations around them, extraction. All possible diseases in the oral cavity are analyzed that could give a similar symptomatics as well as the tactics of the stomatologist until making the final diagnosis. The diagnosis was ex juvantibus elucidated Symptomatic treatment was carried out and paraclinical examinations performed enabling the authors to make the diagnosis recurrent herpetic infection with not typical course upon the oral mucosa induced by the virus of herpes simplex, type I.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41504236,"openaccessinfo":{"externalids":{"MAG":"2418827564","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"While devolution has brought central government geographically and politically closer to local government it has not shielded it from pressures to 'modernise' its political management arrangements. However, devolution has created a different political context to other parts of the UK and this has allowed Scottish local government to voice its views on 'modernisation' with perhaps greater weight than is the case elsewhere. Moreover, 'modernisation' has not resulted in the decline of political parties and the diminution of the 'political' nature of local government decision making. Equally internal council political hierarchies remain important in the decision making processes of councils. However, while the language of 'modernisation' appears to be alien to many Scottish councillors, many of its associated activities are not. While different political parties view the issues relating to 'modernisation' in different lights it is important to note that when councillors form part of a local administration their views on the core issues of 'modernisation' are more similar than the party divide may suggest. Many of the core objectives of 'modernisation' are being delivered within Scottish local government but the forms that 'modernisation' is taking may not be those that Tony Blair or other prominent 'modernisers' may have chosen.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":154621292,"openaccessinfo":{"externalids":{"MAG":"2094336302","ACL":null,"DOI":"10.1177\/095207670301800106","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The 32P-postlabeling method was used to examine the adducts in DNA, polynucleotides, and mononucleotides reacted in vitro with the N-hydroxy and N-acetoxy derivatives of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Adduct profiles were compared to those found in vivo in liver of cynomolgus monkeys fed IQ, MeIQx or PhIP. The N-acetoxy derivatives of IQ, MeIQx and PhIP (generated in situ from the corresponding N-hydroxylamine in the presence of acetic anhydride) each formed three principal adducts in DNA. Adduct 1 of IQ, MeIQx and PhIP was chromatographically identical to the 32P-labeled bis(phosphate) derivative of N-(deoxyguanosin-8-yl)-IQ, N-(deoxyguanosin-8-yl)-MeIQx, and N-(deoxyguanosin-8-yl)-PhIP respectively, and this adduct comprised approximately 65% of total adduct levels found in DNA in vitro. The C8-guanine adduct and the two minor adducts were also found in poly(dG-dC). poly(dG-dC), suggesting that the two minor adducts of IQ, MeIQx and PhIP are also formed on the guanine base. The N-acetoxy derivatives of IQ, MeIQx, and to a much lesser extent PhIP, also formed adducts with adenine-containing polynucleotides including poly(dA), poly(dA).poly(dT) and poly(dA-dT).poly(dA-dT), but these adenine adducts were chromatographically different from those found in DNA. The three guanine adducts of N-acetoxy-IQ, -MeIQx and -PhIP found in vitro in DNA and in guanine-containing polynucleotides were also found in the liver of monkeys fed IQ, MeIQx or PhIP respectively, indicating that metabolic activation via N-hydroxylation and esterification occurred in vivo in monkeys. With each compound, the C8-guanine adduct was the predominant adduct found in vivo. The results indicate similarities among IQ, MeIQx and PhIP in the DNA adducts formed in vitro and in vivo and substantiate the use of the 32P-postlabeling method for comparative adduct studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23521149,"openaccessinfo":{"externalids":{"MAG":"2044465805","ACL":null,"DOI":"10.1093\/CARCIN\/14.7.1389","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to evaluate the multiple dose pharmacokinetics and acute safety of piroxicam and cimetidine alone and in combination in cats. Seven healthy cats were included in this randomized-crossover study. The cats were assigned to groups designated to receive cimetidine alone (15 mg\/kg, p.o., q12 h), piroxicam alone (0.3 mg\/kg, p.o., q24 h), and piroxicam combined with cimetidine (both at aforementioned doses). The cats were dosed for 10 days followed by at least a 2-week washout period between trials. Serial blood samples were collected following the first and last doses and analyzed utilizing a high-performance liquid chromatography with mass spectrometry detection (LC\/MS) assay. Pharmacokinetic parameters were determined using noncompartmental analysis. Endoscopic evaluation of the gastric mucosa was performed and serum urea nitrogen (SUN), creatinine, alkaline phosphatase (ALP), and alanine transaminase (ALT) activities were evaluated. There were not a clinically relevant difference between the pharmacokinetic parameters of piroxicam administered alone or in combination with cimetidine after either the first or last dose. Gastric ulcers were not observed in any cats although gastric erosions were. The SUN, creatinine, ALP, and ALT activities remained within reference ranges for all cats. It appears that once daily, short-term use of piroxicam alone and in combination with cimetidine in cats is relatively safe based on the parameters evaluated in this study. However, further studies are necessary to determine the long-term gastrointestinal safety of piroxicam.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37784147,"openaccessinfo":{"externalids":{"MAG":"2160826337","ACL":null,"DOI":"10.1111\/J.1365-2885.2005.00682.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cerebellar nucleus neurons were recorded in vitro,and dynamic clamping was used to simulate inhibitory synaptic input from Purkinje cells likely to occur in vivo. Inhibitory input patterns with varying synaptic amplitudes and synchronicity were applied to determine how spike rate and spike timing can be controlled by inhibition. The excitatory input conductance was held constant to isolate the effect of dynamic inhibitory inputs on spiking. We found that the timing of individual spikes was controlled precisely by short decreases in the inhibitory conductance that were the consequence of synchronization between many inputs. The spike rate of nucleus neurons was controlled in a linear way by the rate of inhibitory inputs. The spike rate, however, also depended strongly on the amount of synchronicity present in the inhibitory inputs. An irregular spike train similar to in vivo data resulted from applied synaptic conductances when the conductance was large enough to overcome intrinsic pacemaker currents. In this situation subthreshold fluctuations in membrane potential closely followed the time course of the combined reversal potential of excitation and inhibition. This indicates that the net synaptic driving force for realistic input levels in vivo may be small and that synaptic input may operate primarily by shunting. The accurate temporal control of output spiking by inhibitory input that can be achieved in this way in the deep cerebellar nuclei may be particularly important to allow fine temporal control of movement via inhibitory output from cerebellar cortex.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6983811,"openaccessinfo":{"externalids":{"MAG":"2121067468","ACL":null,"DOI":"10.1523\/JNEUROSCI.20-08-03006.2000","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We investigated the effects of supports (CMK-3, SiO2ZrO2, MgO, Al2O3) and promoters (Cu, Ce, Fe) on textual properties of Ni based catalysts. o-Cresol was used as a probe to test the activity of these catalysts under the condition of 230 \u00b0C and nitrogen pressure of 0.1 MPa. The catalysts were characterized by X-ray diffraction, H2 temperature programmed reduction ammonium programmed desorption, and N2 adsorption-desorption isotherms. The results showed that the catalytic performance of Ni\/CMK-3 (the conversion of o-cresol reached 45.4%) was significantly better than the other three kinds of supports. The modification of Ni\/CMK-3 was also investigated and over 60% conversion of o-cresol was obtained after the addition of Ce (64.6%)and Cu (66.8%) in Ni\/CMK-3, whereas the addition of Fe led to a decrease of conversion. In the meantime, Cu changed the products distribution. The appearance of toluene indicated that another pathway existed in the reaction. Accompanied by the ascension of conversion in both sides, side effects also occurred and got more serious. The apparent order of activity for all the tested catalysts was NiCe\/CMK-3> NiCu\/CMK-3>Ni\/CMK-3>NiFe\/CMK-3>Ni\/Al2O3>Ni\/SiO2ZrO2>Ni\/MgO. The reaction pathway, involving three routes, was also mentioned in this study.We investigated the effects of supports (CMK-3, SiO2ZrO2, MgO, Al2O3) and promoters (Cu, Ce, Fe) on textual properties of Ni based catalysts. o-Cresol was used as a probe to test the activity of these catalysts under the condition of 230 \u00b0C and nitrogen pressure of 0.1 MPa. The catalysts were characterized by X-ray diffraction, H2 temperature programmed reduction ammonium programmed desorption, and N2 adsorption-desorption isotherms. The results showed that the catalytic performance of Ni\/CMK-3 (the conversion of o-cresol reached 45.4%) was significantly better than the other three kinds of supports. The modification of Ni\/CMK-3 was also investigated and over 60% conversion of o-cresol was obtained after the addition of Ce (64.6%)and Cu (66.8%) in Ni\/CMK-3, whereas the addition of Fe led to a decrease of conversion. In the meantime, Cu changed the products distribution. The appearance of toluene indicated that another pathway existed in the reaction. Accompanied by the ascension of conversion in both side...","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":98586648,"openaccessinfo":{"externalids":{"MAG":"2083587218","ACL":null,"DOI":"10.1063\/1674-0068\/27\/06\/697-703","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Azacryptophane was obtained by irradiation of the precursor diammonium chloride in the presence of \u03b3-CD (\u03b3-cycodextrin) in aqueous solution. In the liquid-liquid extraction, the azacryptophane showed a moderate affinity toward all alkali metal picrates without any significant selectivity, whereas it selectively extracted both Ag+ and Pb2+ cations in series of heavy metal nitrates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197277493,"openaccessinfo":{"externalids":{"MAG":"2952307068","ACL":null,"DOI":"10.1002\/CHIN.199834192","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this paper is to summarize and evaluate previous attempts at the measurement of cognitive distortions in child molesters. The concept of cognitive distortions has been conceptualized using Ward and keenan's (1999) theory as the manifestation of causal implicit theories concerning the perpetrator, the victim, the surroundings, and the relationships between these elements. After reviewing the research, three generations of studies have been distinguished. The first generation studies were conducted using questionnaires. Their results have provided evidence that child molesters manifest cognitive distortions, but due to insufficient conceptualization, the possibilities of their interpretation were strongly limited. in the second generation studies, a clear conceptualization of the concept of cognitive distortions was delineated and a variety of tools was used, but these did not provide conclusive results. in the third generation studies a simultaneous use of several various methods of measurement of cognitive distortions was postulated. All the previous studies had only partially confirmed the theoretical assumptions. it is necessary to conduct further research, taking into account several groups of participants, with simultaneous measurement of cognitive distortions using several various tools based on the same theoretical conceptualization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53534426,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the findings from an Australian study in which forty-one people, who self-identified as having a psycho-social disability as a result of mental health problems, spoke about their priorities for treatment, care and support within a personalised funding context. The research enabled an improved understanding of the choices about support that people with psycho-social disabilities would make if offered individualised funding packages. Participants prioritised specific supports to improve their health, financial situation, social connection, housing and personal relationships. A relationship with a support worker with a range of skills was identified as a key facilitator of these life goals, but people with psycho-social disabilities also valued opportunities to have discretionary funds to directly address the major problems they face, including stigma, discrimination and poverty. The paper argues that social workers can potentially fill a range of roles and are well placed to work in partnership with people with psycho-social disabilities. Particularly, they have skills in co-production of services, negotiation and advocacy that are required if individual funding is to be maximised for user control, social justice and personal recovery outcomes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":147516376,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/BJSW\/BCV094","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. Luminescence has been studied in the sea pansy Renilla kollikeri , by means of photo-electric recording, and the mode of nervous regulation investigated. 2. The luminescent response is under control of a non-polarized nerve net and is subject to facilitation which occurs terminally, at neuro-photocyte junctions. 3. Facilitation is analysed in detail, and a facilitation-decay curve presented (Fig. 3.). Between successive bursts of stimuli, facilitation may persist for some 10 min. 4. Certain response parameters were measured. Latent period is 0.12 sec.; the response lasts 1 sec., and maximal intensity is reached in 0.22 sec. Conduction speed is 9 cm.\/sec. at 16-17\u00b0C. 5. The refractory period of the response, as determined by high frequency stimulation, is 0.2 sec. It is affected by fatigue and increases under repetitive stimulation. 6. Under repetitive and prolonged stimulation, the animal passes into a hyper-excitatory state and luminous waves continue to arise long after stimulation has ceased. Conditions affecting this post-stimulatory discharge are examined. 7. Comparison of facilitatory processes in quick muscular responses of sea anemones and luminescent responses of sea pens shows that they are essentially similar. From visual observations it appears that facilitation operates by recruitment of photocytes. Luminescence is of sporadic occurrence among coelenterates, and has been independently evolved on many occasions. It is suggested that its mode of regulation has been determined by the characteristics of the nerve net primarily concerned with control of muscles.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":86465236,"openaccessinfo":{"externalids":{"MAG":"2110299508","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Increased rates of reactive oxygen\/nitrogen species (ROS\/RNS) are involved in almost all cancer types, associated with tumor development and progression, causing damage to biomolecules such as proteins, nucleic acids and membrane lipids, in different biological compartments. We used a human tumor xenograft mouse model to evaluate for the first time in parallel the remodeling of fatty acid moieties in erythrocyte membrane phospholipids and the level of ROS-induced DNA lesions in liver and kidney tissues. Using liquid chromatography tandem mass spectrometry the 5\u2032R and 5\u2032S diastereoisomers of 5\u2032,8-cyclo-2\u2032-deoxyadenosine and 5\u2032,8-cyclo-2\u2032-deoxyguanosine, together with 8-oxo-7,8-dihydro-2\u2032-deoxyadenosine, were determined in mice at young (4- and 5-weeks) and old (17-weeks) ages and compared with control SCID mice without tumor implantation. Tumor-bearing mice showed a higher level of ROS-damaged nucleosides in genomic DNA as the age and tumor progress, compared to controls (1.07\u20131.53-fold in liver and 1.1\u20131.4-fold in kidney, respectively). The parallel fatty acid profile of erythrocyte membranes showed a profound lipid remodeling during tumor and age progression consisting of PUFA consumption and SFA enrichment (ca 28% and 58%, respectively, in late stage tumor-bearing mice), markers of enhanced oxidative and proliferative processes, respectively. Membrane lipid remodeling and ROS-induced DNA lesions may be combined to afford an integrated scenario of cancer progression and ageing, reinforcing a holistic vision among molecular markers rather than the biomarker identification in a single compartment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":117737777,"openaccessinfo":{"externalids":{"MAG":"2931837038","ACL":null,"DOI":"10.3390\/cancers11040480","PubMedCentral":"6520748","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6694\/11\/4\/480\/pdf?version=1555932281","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nThe Stroop paradigm evaluates susceptibility to interference and is sensitive to dysfunction in frontal lobes. Performance in the Stroop changes along the development. Despite its usefulness in research and clinical settings, there are few studies with Brazilian samples.\n\n\nOBJECTIVE\nThis study investigates the performance and age effect on Stroop paradigm of Brazilian children.\n\n\nMETHOD\nA sample of 119 children, aged from 7 to 10 years, was submitted to the Victoria version of Stroop.\n\n\nRESULTS\nThe pattern of results observed was similar to that observed in foreign studies with adults and children. Younger children were overall slower than older ones (positive correlation between age and naming time). Also, younger children showed more susceptible to interference than older ones (negative correlation between age and number of errors for the maximal interference condition).\n\n\nCONCLUSION\nThere was an age effect explained in terms of developmental changes in information processing velocity and attention selectivity.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":27613837,"openaccessinfo":{"externalids":{"MAG":"2102031179","ACL":null,"DOI":"10.1590\/S0004-282X2009000300014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel learning algorithm for solving global numerical optimization problems is proposed. The proposed learning algorithm is intense stochastic search method which is based on evaluation and optimization of a hypercube and is called the hypercube optimization (HO) algorithm. The HO algorithm comprises the initialization and evaluation process, displacement-shrink process, and searching space process. The initialization and evaluation process initializes initial solution and evaluates the solutions in given hypercube. The displacement-shrink process determines displacement and evaluates objective functions using new points, and the search area process determines next hypercube using certain rules and evaluates the new solutions. The algorithms for these processes have been designed and presented in the paper. The designed HO algorithm is tested on specific benchmark functions. The simulations of HO algorithm have been performed for optimization of functions of 1000-, 5000-, or even 10000 dimensions. The comparative simulation results with other approaches demonstrate that the proposed algorithm is a potential candidate for optimization of both low and high dimensional functions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10933127,"openaccessinfo":{"externalids":{"MAG":"1766800773","ACL":null,"DOI":"10.1155\/2015\/967320","PubMedCentral":"4538776","ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/cin\/2015\/967320.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We develop a structural cointegrated vector autoregressive (VAR) model with weakly exogenous foreign variables, suitable for a small open economy like South Africa. This type of model is known as an augmented vector error correction model (VECM), referred to by VECX*. We compile the foreign variables with trade-weighted three-year moving average data for 32 countries, to account for the significant change in trade shares over time. This model is novel for South Africa, in two ways: it is the first VECX* developed to analyse monetary policy in the country and the first model that uses time-varying trade weights for the creation of the foreign series. We find three significant long-run economic relations: the augmented purchasing power parity, the uncovered interest parity and the Fisher parity. These long-run relations are imposed on the VECX* to investigate the effect of a monetary policy shock on inflation. The results suggest the effective functioning of the monetary transmission mechanism in South Africa.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55401923,"openaccessinfo":{"externalids":{"MAG":"2099809556","ACL":null,"DOI":"10.1111\/SAJE.12027","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, a practical dynamic resource allocation scheme for real-time variable bit rate (VBR) video transmission is investigated. This scheme uses time-domain adaptive linear prediction, instead of the conventional size prediction of I-, P- and B- frames, to forecast future bandwidth requirement in time. Media delivery index (MDI) is used here as QoS measurement and complementary reference for adjustment. Besides, considering that the practical multi-user application may arouse adjustment collision, an adjustment priorities classified strategy based on the user-level classifications is put forward. Last, a test-bed based on the proposed scheme is constructed and the experimental results show that the bandwidth effective utilization has increased by 20%-60% compared to a fixed service rate with QoS guaranteed and no collisions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":32464684,"openaccessinfo":{"externalids":{"MAG":"2103357660","ACL":null,"DOI":"10.1109\/GLOCOM.2008.ECP.277","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Cagayan de Oro River Basin is the second largest river basin or watershed in Northern Mindanao, occupying an estimated area of 1,373.84 sq. km. The drainage basin was delineated using Shuttle Radar Topographic Mission (SRTM) 90m digital elevation model (DEM). Geographical features were derived from the DEM using geographic information system (GIS) to perform a morphometric analysis of the river basin and evaluate various parameters of linear, areal and relief aspects. Linear aspect analyses showed that the drainage basin has a 7th order stream with a bifurcation ratio of 1.8. Areal aspect demonstrates that the basin has a drainage density of 2.29 km\/mk2 with a circularity and elongation ratios indicating that the basin is less elongated. Relief aspect of the river basin indicates that it has a resistant basement rock formation and susceptible to erosion. Overall evaluation of the various basin parameters revealed that the inherent features of the river basin has made it naturally liable to flooding with anthropogenic activities exacerbating the extent of risks.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":134997294,"openaccessinfo":{"externalids":{"MAG":"2920821515","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Following our previous demonstration that p,p'-DDE (dichlorodiphenylchloroethylene), at environmentally relevant concentrations, can rapidly increase intracellular calcium [Ca2+]i concentrations in human granulosa-lutein cells, we examined whether other pesticides, such as Kepone, o,p-DDE and methoxychlor, have similar effects. Cultured human granulosa-lutein cells were loaded with Fura-2 AM, and changes in [Ca2+]i concentrations within small areas of single cells were studied with a dynamic digital Ca2+ imaging system. Kepone, at concentrations of 0.2-2 nmol\/ml, consistently increased [Ca2+]i concentrations 2-6 times higher than baseline values within minutes of exposure. Methoxychlor at concentrations of 2.8-280 nmol\/ml failed to alter [Ca2+]i levels consistently in cells from 10 patients. However, at 0.28 and 1.4 nmol\/ml, increases in [Ca2+]i concentrations could be elicited by methoxychlor. The isomer o,p-DDE at 3 nmol\/ml increased [Ca2+]i in granulosa cells of 11\/20 patients. Pertussis toxin treatment inhibited the [Ca2+]i increases induced by estradiol, p,p'-DDE, o,p-DDE and methoxychlor, but not by Kepone or progesterone, indicating that Kepone and progesterone may act through an insensitive G protein-coupled receptor. The [Ca2+]i increases induced by Kepone also occurred in Ca2+-free medium, suggesting that [Ca2+]i mobilization occurred from the smooth endoplasmic reticulum. Thapsigargin and cyclopiazonic acid, two inhibitors of the endoplasmic reticulum Ca2+ pump, also stimulated [Ca2+]i increases but did not inhibit the Ca2+ response to all the pesticides. These results demonstrate that pesticides can have a rapid effect on human granulosa-lutein cells, and a nongenomic mechanism of action is suggested.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":26867124,"openaccessinfo":{"externalids":{"MAG":"2049672012","ACL":null,"DOI":"10.1530\/REP.1.00922","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \n \nTheatre training is unique in the sense that it challenges the notions of 'conscious' and 'unconscious' mind, especially when it comes to movement and voice practice. Of course there is a focus on the performance outcome (whether it be scripted or improvised) but the foundations of performance are equally as important, which is sometimes referred to as 'pre-acting'. These necessary skills such as physical and vocal training, and improvisation form some of the foundations of acting. The student actor also needs to have an awareness of self and others, space and time. Being aware of personal habits, then having the skills to eliminate them, and adapting ones own voice and body is empowering. Also dealing with other performance and having an awareness of space prepares them for the stage and beyond. This paper will discuss how I have experimented and combined various Western and non-Western voice and movement methods in order to assist the unlocking of imagination, creativity and discovery of self. \n \nKeywords: Voice, Movement, Performance, Conscious, Pre-acting, Suzuki","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":146234453,"openaccessinfo":{"externalids":{"MAG":"2223193843","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intravenous port-systems are predominantly used for long-term chemotherapy in oncology. 164 of our patients were implanted with a Port-a-Cath and 165 patients with a Chemosite system. Indications, the duration of implantation, the duration of use, the access and complications were analysed. This retrospective study analyses 329 tumor patients, who have been treated at the Cancer Center Klinik im Park from September 1987 until February 1998. The preferred access of implantation were: v. subclavia (47%) and v. cephalica (35%). The average duration of implantation was 279 days for the Port-a-Cath system and 443 days for the Chemosite system. The most frequent complication immediately following surgery was a pneumothorax in 4% of the patients. The frequency of late complications was: thromboses 2%, infections 4%. This study analyses our experiences with fully implantable permanent intravenous catheter-systems in 329 tumor patients. These catheters can be used for very long periods with a low rate of complications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33953097,"openaccessinfo":{"externalids":{"MAG":"2417155672","ACL":null,"DOI":"10.1024\/0040-5930.58.7.425","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract The Human Genome and HapMap projects have provided the tools and information that will aid in understanding how nutrients alter the expression of an individual's genetic information and why individuals differ in metabolism of foods at the molecular level. The study of how genes and gene products interact with dietary chemicals to alter phenotype and, conversely, how genes and their products metabolize nutrients is called nutritional genomics or \"nutrigenomics.\" This new field has received considerable attention in the last 6 years, most of which has been on the promise rather than on scientific results from nutrigenomic experiments. Funding for nutrigenomics research focused primarily on individual laboratory projects in the 1990s and early 2000s. The novelty of combining nutrition and genetics limited that funding to a relatively small number of laboratories. Only in the past 3 years have centers been funded to foster collaborations and conduct large-scale projects that are studying nutrient-gene interactions. The increase in interest and funding is beginning to generate the critical mass to realize the promise of nutritional genomics. Clin Chem Lab Med 2007;45:279\u201387.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25597284,"openaccessinfo":{"externalids":{"MAG":"2091501710","ACL":null,"DOI":"10.1515\/CCLM.2007.057","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae are classified as serious threats to human health by the U.S. Centers for Disease Control and Prevention. Water used for irrigation of fresh produce can transmit such resistant bacteria directly to edible plant parts. We screened ESBL-producing Escherichia coli, Enterobacter cloacae, and Citrobacter freundii isolated from irrigation water for their potential to transmit resistance to antibiotic-susceptible E. coli. All strains were genome-sequenced and tested in vitro for transmission of resistance to third-generation cephalosporins on solid agar as well as in liquid culture. Of the 19 screened isolates, five ESBL-producing E. coli were able to transfer resistance with different efficiency to susceptible recipient E. coli. Transconjugant strains were sequenced for detection of transferred antibiotic resistance genes (ARGs) and compared to the known ARG pattern of their respective donors. Additionally, phenotypic resistance patterns were obtained for both transconjugant and corresponding donor strains, confirming ESBL-producing phenotypes of all obtained transconjugants.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220386694,"openaccessinfo":{"externalids":{"MAG":"3039715920","ACL":null,"DOI":"10.3390\/microorganisms8070978","PubMedCentral":"7409067","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2076-2607\/8\/7\/978\/pdf?version=1594269108","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The adoption and abandonment of first names through time is a fascinating phenomenon that may shed light on social dynamics and the forces that determine cultural taste in general. Here we show that baby name dynamics is governed almost solely by deterministic forces, even though the emerging abundance statistics resembles the one obtained from a pure drift model. Exogenous events are shown to affect the name dynamics very rarely, and most of the year-to-year fluctuations around the deterministic trend may be attributed solely to demographic noise. We suggest that the rise and fall of a name reflect an \"infection\" process with delay and memory. The symmetry between adoption and abandonment speed emerges from our model without further assumptions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8972459,"openaccessinfo":{"externalids":{"MAG":"2150749843","ACL":null,"DOI":"10.1371\/journal.pone.0038790","PubMedCentral":"3380031","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0038790&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Ethics and the Environment includes contributions from distinguished philosophers, humanists, politicians, geologists, chemists and physicists. This volume opens with an historical and philosophical background to provide a basis for discussion of significant contemporary changes in ethical theory. Key themes and concepts in the environmental ethics debate are addressed, including property rights, organism and community, and environmentalist values. The political and legislative dimensions of environmental issues are analyzed. The book concludes with discussion of two environmental problems that affect Long Island, nuclear energy and safe water supply. Contributors: E. Shirk, M. Soupios, A. Berleant, C. Mooney, D. Sprintzen, E. Katz, E. Walther, the Honorable P.G. Halpin, T. Goldfard, J. Kluewer, R. Watson, and J. Kane. Co-published with the Long Island Philosophical Society.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":142298361,"openaccessinfo":{"externalids":{"MAG":"610490208","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Though often observed that the Acts narrative is the defining paradigm for Pentecostal doctrine and practice, in point of fact Mk 16.9-20 functions as the 'litmus test' of the early Pentecostal Movement's fulfilling of the apos tolic mandates given by Jesus and carried out by the church. Despite the well-known text-critical problems surrounding the passage, the place of Mk 16.9-20 was unrivaled within the early Pentecostal literature in position and significance. Drawing on methodological approaches including textual criticism, literary analysis, canonical criticism and Wirkungsgeschichte, this study argues for the reappropriation of Mk 16.9-20 in Pentecostal theology and practice. The study begins by identifying the place of Mk 16.9-20 in early Pentecostal literature, surveys early Pentecostal responses to the textual problems, and compares these responses with others of the period. This is followed by a re-examination of Mk 16.9-20 in the manuscript tradition, a modest attempt to identify the origin of these non-Markan verses, and a discussion of their authority. The final major section of this article offers a variety of literary, theological and canonical observations on this 'Longer Ending'. The study concludes with an invitation to those within the Pentecostal tradition to reappropriate this most significant passage in the articulation of contemporary Pentecostal theologies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":143899987,"openaccessinfo":{"externalids":{"MAG":"1977403447","ACL":null,"DOI":"10.1177\/096673690301100201","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The measurement of total scatter losses is a major prerequisite for the development, optimization and commercialization of high quality optical components. Especially in laser technology, optical scattering gained of importance in the source of the development of laser system with ever increasing output power and improved beam parameters. Besides its influence on the efficiency of laser systems and the beam steering arrangement, total scattering is an important safety aspect for application of these laser systems in materials processing, medicine and fundamental research. As a consequence of this global trend, working groups of TC 172\/SC 9 initialized the development of an International Standard for the measurement of total scattering in optical components.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":109772404,"openaccessinfo":{"externalids":{"MAG":"1966370739","ACL":null,"DOI":"10.1117\/12.360187","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The soybean cyst nematode (SCN), Heterodera glycines, found in most soybean growing regions in the world, is considered the most economically damaging pathogen of soybean worldwide. A survey conducted in the northern provinces of Mazandaran and Golestan, the main soybean-producing areas in Iran, revealed SCN was widespread in different localities of these regions. Of the 55 and 88 soil samples collected from soybean fields in Mazandaran and Golestan provinces, respectively, ten (18.8%) and 23 (26%) samples were infested with H. glycines; the population densities of second-stage juveniles (J2) and eggs ranged from 500 to 60 000 and 500 to \u2265100 000 per 250 cm3 soil, respectively. These population densities of H. glycines are indicative of reductions in soybean yield. HG Type tests were conducted on 16 field populations. HG Type 0 (race 3) was the most common with 94% frequency, whereas HG Type 7 (race 6) was found in 6% of tested populations. Most populations of H. glycines parasitised PI88788 and PI548316. Eight of the most commonly used soybean cultivars were tested against H. glycines HG Type 0; seven of them, Sepideh, Sahar (Pershing), Gorgan 3, Williams 82, JK (Sari), BP (Telar) and Hill, had high female indices and were considered susceptible to HG Type 0. Only the cultivar DPX showed low female indices and was resistant to race 3. The initial observations showed that the first life cycle of SCN required 30-34 days in early-planted fields (late May and early June), whereas in late-planted fields (early July), white females were visible 20 days after planting. Several generations could be expected in a single growing season under field conditions in northern Iran.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":84981602,"openaccessinfo":{"externalids":{"MAG":"2066458738","ACL":null,"DOI":"10.1163\/156854108786161535","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Flax lodging is an\nissue of great interest for producers due to its economic impact. To better\nunderstand its effects at the cell wall and stem scale, new knowledge regarding\nthe cell wall composition dynamics during cell wall development and after a 90\u00b0\ntilt bending stress is reported. Deep-Ultra Violet fluorescence emission (DUV) dynamics\nrecorded at the Synchrotron SOLEIL-DISCO beamline by multichannel\nautofluorescence imaging is reported for five cellular wall types of flax stems\nafter an artificially induced gravitropic reaction. Three flax growth\ndevelopment stages, namely, the vegetative stage (VS), the fast growth (FG) and\nthe mature stage (MS), were selected in normal plants, referred to as the control\nplants, or in gravitropic-induced response plants, referred to as 90\u00b0 tilted\nplants.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":236392255,"openaccessinfo":{"externalids":{"MAG":"3165530945","ACL":null,"DOI":"10.26434\/CHEMRXIV.14665911.V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo establish a scale of knowledge, attitude, and behavior of lifestyle interventions among a population at high risk of diabetes with good cultural adaptability, validity, and reliability.\n\n\nMETHODS\nThe original item pool was formed based on a literature review, group discussions, and interviews with experts. We used the Delphi method to determine core items of the scale (30 cases in the first round and 26 cases in the second round, respectively). We invited 30 experts from clinical medicine, nursing, preventive medicine, health education, and community diabetes prevention and control to completed expert consultation tables. For each item, experts were asked to provide an importance score, the judgment basis, and a familiarity score. We analyzed the positive coefficient, authoritative coefficient, degree of concentration, and harmonious coefficient, to determine the selected items. Using face-to-face questionnaire surveys, 31 participants at high risk of diabetes were selected for the pilot study. We analyzed understanding of the scale's content and presentation and corrected the scale based on the analysis.\n\n\nRESULTS\nWe received 26 and 23 inquiry forms, respectively, in two rounds of consultation. Responses rates of the two rounds were 87% and 88%. The scores of authoritative coefficients were 0.79 \u00b1 0.14 and 0.87 \u00b1 0.10. The score of total scale in the first consultation was 4.32\u00b10.25, the coefficient of variation was 0.06, and the coefficient of concordance was 0.163; in the second consultation, these were 4.58\u00b10.21, 0.05, 0.150, respectively. In the first consultation, 22 experts proposed amendments and made suggestions, a rate of 85% (22\/26). After the second round, 30 items were included in the final scale. In the pilot study, 13 males and 18 females with high risk of diabetes were interviewed. Average age of the population was (62.24 \u00b1 10.23) years. The time to complete the survey was (9.35 \u00b1 2.71) minutes. After the pilot study was completed, the order of the items was adjusted to ensure a reasonable and logical scale.\n\n\nCONCLUSION\nWe developed the scale of knowledge, attitude, and behavior of lifestyle intervention in a diabetes high-risk population, using the Delphi method and a pilot study. Overall, the findings indicate that input from experts during development facilitates achievement of satisfactory concentration and coordination levels, and the use of this scale will produce credible results.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45503828,"openaccessinfo":{"externalids":{"MAG":"2501628389","ACL":null,"DOI":"10.3760\/cma.j.issn.0253-9624.2016.07.003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The determinants of risk attitude in couples are explored using data from the German Socio-Economic Panel over the period 2004 to 2009. The focus of the analysis is the repeated responses to the survey question about general willingness to take risk. Responses to this question are provided on a 0-10 Likert scale. We focus on couples in the data set, and we apply the bivariate panel ordered probit model to the analysis of the simultaneous determination of the male's and the female's risk attitude. A number of individual characteristics, including age, height, education and household income, are found to have strong effects on risk attitude, in some cases differing markedly between the male and the female. Both the individual-specific effects and the observation-specific error terms are assumed to have non-zero correlations between the two equations. These correlations are estimated to be +0.27 and +0.28 respectively. We consider the former to be a key parameter, since its positive sign may be interpreted as a form of homophily: individuals tend to form partnerships with others having a similar risk attitude.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15939845,"openaccessinfo":{"externalids":{"MAG":"2169730980","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Urinary tract infections (UTIs) are common in infancy and childhood, affecting approximately 6\u20137% of girls and 2\u20133% of boys. Fourteen years have passed since the Royal College of Physicians published clinical guidelines for the management of UTI in children. Large numbers of children undergo imaging investigations and receive antibiotic prophylaxis for extended periods. A Cochrane systematic review in 20041 found inadequate data from available randomised controlled trials (RCTs) to provide evidence as to whether any intervention (antibiotics or surgery) in children with vesico-ureteric reflux confers worthwhile health benefits.\n\nIn 1999 the American Academy of Pediatrics published a guideline on the diagnosis and management of UTI in children under the age of 2 years, based on a rigorous literature search.2 However, this did not investigate the evidence for a link between childhood UTIs, renal abnormalities, and long term outcome with or without treatment, and its recommendations are therefore open to question.3 Although the National Institute for Health and Clinical Evidence (NICE) is undertaking an evidence based guideline on the subject, this will not be published until May 2007.\n\nIn the meantime, three recent systematic reviews address aspects of the management of UTI, and provide a useful insight into current evidence as a basis for clinical practice.\n\nThe first was carried out by the York University Centre for Reviews and Dissemination for the National Health Service R&D Health Technology Assessment Programme.4 Its findings are summarised in Effective Health Care .5 It covers the evidence for the diagnosis and evaluation of UTIs in children under 5 years of age.\n\n### Key points","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":72979203,"openaccessinfo":{"externalids":{"MAG":"2100684952","ACL":null,"DOI":"10.1136\/ADC.2005.084517","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The photoluminescence of Si nanocrystals is often assigned to exciton recombination confined within the nanocrystals. However, localized radiative or non\u2010radiative defects at the nanocrystal (NC) interface can drastically influence the NCs ensemble and reduce the luminescence output. In addition, size of the NCs as well as embedding host are playing a major role and have a significant influence on the optical properties. Here we summarize our work on size controlled Si NCs based on the SiOx\/SiO2 superlattice approach. We will discuss how to distinguish between defects at the NC\u2010Si\/SiO2 interface and defects in the matrix and demonstrate ways for effective NC surface passivation. The influence of different annealing ambient used for crystallization will be shown. Such perfectly defect passivated and size controlled samples will be used as a model system to discuss size dependent quantum properties such as the temperature dependent blue shift of the Si NC band gap.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":120059034,"openaccessinfo":{"externalids":{"MAG":"1967788833","ACL":null,"DOI":"10.1002\/pssa.201200734","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Looking beyond the Highway is an examination of road history and roadside attractions specific to the South. Focused in part on numerous aspects of thematerial culture landscape of the Dixie Highway, the essays consider the politics of roadbuilding, roadside entertainment, the buildings and businesses one might encounter along the road, and regional adaptations to the needs and desires of northern tourists. Following the Dixie Highway from southern Illinois to Florida with sidetrips down other southern roads, the essays cover a wide variety of subjects, many of which will resonate with anyone who has ever lived in or vacationed in the South: Harrison Mayes's Get Right With God signs; the park-and-pray craze of outdoor drive-in church services; the rise and demise of brick highways; the fierce political battle over the route of the Dixie Highway; beach music and the evolution of motel architecture in Myrtle Beach; Florida's early tourist towers; and the commercial development of Tennessee caves as tourist attractions. Covering a landscape that includes Tennessee, Georgia, North Carolina, Florida, Mississippi, Indiana, Virginia, Arkansas, Ohio, Kentucky, Alabama, and Illinois, the anthology shows that there was and still is a distinctive southern culture and how roads have influenced that culture. As lively as they are diverse, thearticles provide a solid background for understanding roadside ephemera that have disappeared or are quickly disappearing. Ranging from the serious to the light-hearted and including descriptions of American road and roadside icons to kitsch, the book will appeal to anyone with an interest in road history and roadside architecture.\"","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":126606738,"openaccessinfo":{"externalids":{"MAG":"586663655","ACL":null,"DOI":"10.5860\/choice.44-6425","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this study, a new sensitive and simple method for simultaneous separation and preconcentration of Cu2+, Zn2+, Pb2+, and Cd2+ ions from various real samples prior to their measurements by flame atomic absorption spectrometry has been developed. The proposed method is based on the utilization of multiwalled carbon nanotube in combination with (E)-N1-(4-nitro-benzylidene)-N2-(2-((E)-4-nitrobenzylideneamino)ethyl) ethane-1,2-diamine as a solid phase extractant. The separation parameters for effective adsorption of Cu2+, Zn2+, Pb2+, and Cd2+ ions, including the effects of pH, amount of ligand, sample and eluent flow rate, and common coexisting ions were examined. The optimum pH for the separation of Cu2+, Zn2+, Pb2+, and Cd2+ ions on the new sorbent was 6.0. The detection limits based on 3 sigma (n\u2009=\u200915) for Cu2+, Zn2+, Pb2+, and Cd2+ ions was 0.69, 0.48, 8.9, and 0.25\u2009ng\u2009mL\u22121 while respective preconcentration factor for Cu2+, Zn2+ ions was 80 and for Pb2+ and Cd2+ ion was 20 and 60, respectively, with relative standard deviations between 0.7% and 5.8%. The proposed preconcentration procedure was applied to the analysis of various real samples.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":93475054,"openaccessinfo":{"externalids":{"MAG":"1976857646","ACL":null,"DOI":"10.1080\/02772248.2011.572885","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This practical action research examines the choice between using unabridged novels and graded readers in the context of an extensive reading project. The comparison mainly consists of data on word-count gains as recorded throughout two ten-week sessions with the same target group. For the comparison, thirty-five first year non-English-major Japanese university EFL students in a year-long communication class were assigned to read an unabridged novel through a ten-week period during the first semester of the school year. For another ten-week period during the second semester, the same group read graded readers in tandem with the M-Reader computer-assisted language learning program. The findings suggest that a change in pedagogy in favor of the method involving graded readers with the M-Reader program is the most beneficial choice for the course.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":235329498,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nTo develop a method for the simultaneous and rapid detection of five mushroom toxins (\u03b1-amanitin, phallacidin, muscimol, muscarine and psilocin) in blood by ultra-high performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS).\n\n\nMETHODS\nThe blood samples were precipitated with acetonitrile-water solution(Vacetonitril\u2236Vwater=3\u22361) and PAX powder, then separated on ACQUITY Premier C18 column, eluted gradient. Five kinds of mushroom toxins were monitored by FullMS-ddMS2\/positive ion scanning mode, and qualitative and quantitative analysis was conducted according to the accurate mass numbers of primary and secondary fragment ions.\n\n\nRESULTS\nAll the five mushroom toxins had good linearity in their linear range, with a determination coefficient (R2)\u22650.99. The detection limit was 0.2-20 ng\/mL. The ration limit was 0.5-50 ng\/mL. The recoveries of low, medium and high additive levels were 89.6%-101.4%, the relative standard deviation was 1.7%-6.7%, the accuracy was 90.4%-101.3%, the intra-day precision was 0.6%-9.0%, the daytime precision was 1.7%-6.3%, and the matrix effect was 42.2%-129.8%.\n\n\nCONCLUSIONS\nThe method is simple, rapid, high recovery rate, and could be used for rapid and accurate qualitative screening and quantitative analysis of various mushroom toxins in biological samples at the same time, so as to provide basis for the identification of mushroom poisoning events.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247010010,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.12116\/j.issn.1004-5619.2020.301001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The problem of constructing globally convergent, reduced-order observers for general nonlinear systems is addressed. It is shown that an asymptotic estimate of the unknown states can be obtained by rendering attractive an appropriately selected (invariant) manifold in the extended state space. Current results on nonlinear observer design require that the nonlinearities appearing in the system equations are either linear functions of the unmeasured states or monotonic functions of a linear combination of the states. In this paper we relax these two assumptions by allowing for a wider class of nonlinearities to appear in the system equations. The proposed approach is applied on several examples including a perspective vision system and a general two-degrees-of-freedom mechanical system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":8155243,"openaccessinfo":{"externalids":{"MAG":"2137371449","ACL":null,"DOI":"10.1109\/TAC.2008.2007045","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The modified Reynolds equation for power-law fluid is derived from the viscous adsorption theory for thin film elastohydrodynamic lubrication (TFEHL) of circular contacts. The lubricating film between solid surfaces is modeled as three fixed layers, which are two adsorption layers on each surface and a middle layer. The differences between classical EHL and TFEHL with non-Newtonian lubricants are discussed. Results show that the TFEHL power law model can reasonably calculate the pressure distribution, the film thickness, and the velocity distribution. The thickness and viscosity of the adsorption layer and the flow index influence significantly the lubrication characteristics of the contact conjunction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":109640919,"openaccessinfo":{"externalids":{"MAG":"1720543131","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMM.764-765.160","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Providing information to consumers through the label is a means for food companies to inform consumers about product's attributes, including the country of origin (COO). In the EU, COO labeling has been made mandatory for several categories of food products, to enable consumers to make informed choices at the point of sale. In particular, Regulation (EU) No 29\/2012 has introduced a mandatory country-of-origin labeling system for extra virgin olive oil (EVOO). In the present study, conducted in Italy, we test whether there is a price differential associated with the COO information for EVOO. To this end, we employ a hedonic price model and data about the purchase of EVOO products collected from 982 consumers at the supermarket checkout. Having interviewed these consumers, we also assess the share of EVOO consumers that correctly identify the country of origin of the product purchased. Our findings point out that, in Italy, the EVOO with domestic origin, indicated on the label, benefits of a premium price equal to +35% compared to the product labeled as blend of European EVOOs, while a discount of \u221210.8% is attached to EVOOs from a non-European origin. A significant share of consumers in our sample (19.04%) is, however, unable to correctly identify the origin of the EVOO purchased. This label misuse mostly occurs among consumers who report that they had purchased Italian EVOO, while they had actually purchased a blend of European EVOOs. Female and more highly educated consumers are less likely to misuse label information about the product's origins.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220746638,"openaccessinfo":{"externalids":{"MAG":"3043186201","ACL":null,"DOI":"10.3390\/nu12072150","PubMedCentral":"7400813","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6643\/12\/7\/2150\/pdf?version=1595154055","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Vibrations often occur in industrial machinery. One of solution to reduce excessive vibration is to add Dynamic Vibration Absorber (DVA). The principle of dynamic vibration absorber working is addition mass of absorber and spring in the main system. DVA reduce vibration from main system with resulted vibration which has opposite direction to vibration main system. According to the research by Pachpute [1], Using DVA is proven to reduce main system vibration which operated by natural frequency significantly. This research had been design a mechanism of vibration absorber and energy harvesting with Cantilever Piezoelectric Vibration Absorber (CPVA) method. In this research, the main system is flat plate which supported by four springs. The plate has been received an excitation force from springs below which are connected with eccentric masses on DC motor. Spring used to support flat plate has the same value of spring stiffness 300 N \/ m. So the excitation that occurs on flat plate is only in translational direction. This research are going to analysis various amplitude of eccentric mass at 0.025 m, 0.030 m, and 0.035 m. Rotational velocity of DC motor is 20.61 rad\/s (natural frequency), 22.05 rad\/s (harvesting frequency), and 25 rad\/s (valley frequency). Various number of cantilever piezoelectric which used are 2600, 2800, and 3000 pieces. The result from simulation process shows that the highest value of power generation and percentage of CPVA reduction is 3.52E-7 watt and 20.36% in natural frequency. Furthermore, the simulation also resulted CPVA characteristic and various number of optimum range piezoelectric in 1400 2400 pieces. In that following range, power generation and percentage reduction of main mass displacement that can be reached by CPVA are 5.78E-7 watt and 22.75%.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":53505548,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of winter legume cover crops for erosion control and to provide additional N to the soil is well established. Other potential benefits to legume cover crops besides N additions have been recognized, but have not been quantified. The objective of this study was to separate the fixed-N effects from the rotation effects in a winter legume cover cropping system. A field study was initiated in 1989 on a Norfolk loamy sand (fine, loamy, siliceous, thermic Typic Kandiudult) in east-central Alabama. Corn (Zea mays L.) was grown following (i) 'Tibbee' crimson clover (THfolium incarnatum L.), (ii) a partially ineffective-nodulating crimson clover, CH-1, (iii) rye (Secale cereale L.), and (iv) winter fallow. The plots were split into four rates of fertilizer N (0, 56, 112, and 168 kg N ha -1 ) in a split-plot experimental plan. An evaluation of different methods of distinguishing fixed-N vs. rotation effects of the winter annual legume cover crop to a subsequent corn crop was made. Regression analysis of the effect of N application rates on N 2 fixation by crimson clover (fertilized with 45 kg N ha -1 ) indicated that CH-1 clover biomass contained approximately 40 and 101 kg N ha -1 and Tibbee clover contained approximately 51 and 119 kg N ha -1 in 1990 and 1991, respectively. In both years of the study, crimson clover substantially increased corn yield compared with winter fallow, with a yield increase at the highest fertilizer N application level of 7 and 22% for 1990 and 1991, respectively. Estimates of yield increases due to rotation ranged from negative to 40%. The data indicated that winter cover crops improve corn yield and that besides soil N availability, there was very little difference between the beneficial effects of clover and the rye cover crops to corn.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":3}},"corpusid":84540111,"openaccessinfo":{"externalids":{"MAG":"2016992016","ACL":null,"DOI":"10.2134\/AGRONJ1996.00021962008800040005X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Beans are traditional elements on the table of the Brazilian population. In spite of this, the production of beans has been falling in Brazil in the last years. This article tries to identify the causes for the lack of motivation for growing beans in Brazil. It also aims to point out which factors are the most relevant for obtaining an expressive plantation and bean harvest. Given this, we were able to develop a system based on fuzzy logic that can be useful for measuring the expected loss until the bean harvest. With the output from such system the farmer can be provided incentives to start planting once that loss is considered acceptable.\u00a0 In order to generate the rules of the system the multicriteria TOPSIS method is used. The prototype fuzzy system explained and proposed in this article can be further expanded by agricultural experts thus leading to a large scale planting of beans.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":243871113,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.14807\/ijmp.v9i2.756","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"http:\/\/www.ijmp.jor.br\/index.php\/ijmp\/article\/download\/756\/826","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Mastitis is considered the most costly disease in the U.S. dairy industry. Treatment of clinical mastitis is the major reason for antibiotic contamination of products on U.S. dairy farms. A survey of 183 dairy producers was conducted to determine their perceptions regarding clinical mastitis treatments and what constituted their treatment regimens. Results indicated that 33% of dairy producers used a coliform vaccine, 10% used a Staphylococcus aureus vaccine, and 38% did no prestripping before milking cows. Obtaining a clinical cure (restoration of normal milk) was considered the most important aspect of mastitis treatment success (110\/ 183; 60%) compared to bacteriological cure (absence of bacterial pathogen), somatic cell count cure (cells count back to near normal concentrations), milk production (back to near pre-mastitis levels), and udder firmness (back to near normal firmness). Average treatment success for mastitis reported by the 183 producers was 70%, with a range of 10 to 100%. Seventy-three (92%) producers listed \"off-feed\"\u009d as a good measure of the severity of clinical mastitis, followed closely by general appearance (91%). Appearance of udder and milk, droopy ears, appearance of the eyes, and low milk production were other popular methods used to determine the severity of clinical mastitis. Dairy producers believed that 5.3 days (range of 1 to 45 days) passed between first recognition of a clinical case until normal milk was restored. Only 34% of producers utilized rectal temperatures as a diagnostic tool for mastitis. Many treatments used were extra-label and some were potentially illegal. However, the results presented demonstrate a wide diversity of products used and a general lack of consensus of what is considered efficacious mastitis treatment. In addition, drug dosages and duration of therapy varied considerably. Greater education on proper dosages, durations, and potential efficacy of treatments should be beneficial. A clear need exists for conducting efficacy studies to help establish necessary and justified treatments for clinical mastitis.; Dairy Day, 2003, Kansas State University, Manhattan, KS, 2003;","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":195835148,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The South Carolina Division of Motor Vehicles recently replaced its 22-year-old computer system with a new $40 million system in an effort to resolve longstanding problems and improve service. The implementation of the new system, however, was plagued with difficulties. This article examines the implementation and suggests ways to prepare managers, employees, and other stakeholders before new technology is implemented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36432176,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objective: Therapeutic guidelines recommend the combination of drugs as necessary to control type 2 diabetes (T2D). This research assessed the effectiveness of pioglitazone (Pio), metformin (Met) and sulfonylurea (SU) combinations in the routine clinical practice. Research design and methods: A nationwide, 12-month prospective, observational cohort study was performed in 2294 patients with T2D (50.3% females, mean age: 61.1 years, mean body mass index: 30.2\u2009kg\/m2, mean time since diagnosis: 8.5 years) who started, at the discretion of treating physician, oral antihyperglycaemic treatment with either Pio\u2009+\u2009SU, Pio\u2009+\u2009Met or SU\u2009+\u2009Met because of inadequate control with previous therapy. Fasting plasma glucose (FPG), glycohaemoglobin (HbA1c), lipids, blood pressure, and anthropometric parameters were measured, and 10-year cardiovascular risk was estimated. Results: FPG, HbA1c and total cholesterol at baseline had mean values (184.6\u2009mg\/dl, 8.5% and 246.0\u2009mg\/dl, respectively) associated with an excess of micro- and macrovascular risk. The mean changes from baseline in the Pio\u2009+\u2009SU, Pio\u2009+\u2009Met and SU\u2009+\u2009Met cohorts were, respectively, \u221237.9, \u221232.7 and \u221225.8\u2009mg\/dl for FPG; \u22121.1, \u22121.0 and \u22120.7% for HbA1c; \u221230.7, \u221238.7 and \u221217.1\u2009mg\/dl for triglycerides; and +2.3, +2.5 and +0.6\u2009mg\/dl for HDL cholesterol. In consequence, the estimated 10-year cardiovascular risk decreased more in the Pio cohorts, particularly with Pio\u2009+\u2009Met (1.7% versus 1.4% Pio\u2009+\u2009SU and 1.0% SU\u2009+\u2009Met \u2013Framingham equation\u2013 and 0.6% versus 0.4% SU\u2009+\u2009Met \u2013 Systematic Coronary Risk Evaluation model\u2013). Related adverse events were significantly (p\u2009=\u20090.016) more frequent in Pio cohorts (4.7% with Pio\u2009+\u2009SU, 5.1% with Pio\u2009+\u2009Met) than in the SU\u2009+\u2009Met cohort (2.4%). Conclusions: In patients with T2D failing therapy, mostly SU or Met monotherapy, pioglitazone add-on treatment was associated with a significant improvement of micro- and macrovascular risk estimations. These results from real-life clinical conditions support the findings of prior randomised trials, although they should be interpreted with caution because of the observational, nonrandomised design.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45543554,"openaccessinfo":{"externalids":{"MAG":"2079283767","ACL":null,"DOI":"10.1185\/03007991003733239","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Educational process mining (EPM) is an emerging field in educational data mining (EDM) aiming to make unexpressed knowledge explicit and to facilitate better understanding of the educational process. EPM uses log data gathered specifically from educational environments in order to discover, analyze, and provide a visual representation of the complete educational process. This paper introduces EPM and elaborates on some of the potential of this technology in the educational domain. It also describes some other relevant, related areas such as intentional mining, sequential pattern mining and graph mining. It highlights the components of an EPM framework and it describes the different challenges when handling event logs and other generic issues. It describes the data, tools, techniques and models used in EPM. In addition, the main work in this area is described and grouped by educational application domains. WIREs Data Mining Knowl Discov 2018, 8:e1230. doi: 10.1002\/widm.1230","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":3396412,"openaccessinfo":{"externalids":{"MAG":"2757875814","ACL":null,"DOI":"10.1002\/widm.1230","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Morinda citrifolia L. is a plant of the family Rubiaceae and is known as Indian mulberry or Noni in India. It is a perennial herb native to Southeast Asia and has been used over the years as a food supplement and medicinal plant. Noni fruits are reported to possess anticancer, fungicidal, antiviral and antiarthritic effects. The objective of our study is the screening of the immunomodulatory activity of the total extract, fractions, and isolated compounds of Noni fruits to identify their bioactive compounds. To achieve our goal, an ethanol extract (EE) was prepared from Noni fruits. Fractionation and purification of the EE were accomplished. The cell-mediated immune (CMI) response in prednisolone-induced immunosuppression rats was evaluated. The toxicity of the EE, fractions and isolated compounds on the differentiated THP-1 macrophage was assessed using the MTT viability assay. Moreover, the inflammation-related immune responses in lipopolysaccharide (LPS)-induced THP-1 macrophage activation were evaluated. Fractionation of the EE gave three fractions, dichloromethane (DCMF), water (WF) and methanol (MF). Purification of DCMF yielded stigmast-7-ene-3-ol (M1), 28-hydroxy-3\u03b2-acetoxy-9-dehydrogramisterol (M2), 3\u03b2-acetoxy-taraxast-20(30)-ene-21-ol (M3), 22-dehydroclerosterol (M4) and 22-dehydroclerosterol-3-O-\u03b2-d-glucopyranoside (M5), while purification of MF yielded quercetin (M6), hesperidin (M7), naringin (M9) and gallic acid (M8). The results revealed that DCMF elicited an increase in paw edema to the extent of 35.8%. All the tested samples had no cytotoxic effect on THP-1 macrophages. Co-treatment of the LPS-induced macrophages with DCMF, M2, M3, and M6 decreased the production of TNF-\u03b1, IL-1\u03b2, and IL-6\/IL-10. The expression of iNOS, COX-2, and NF-\u03baB decreased to 0.14 \u00b1 0.02, 0.15 \u00b1 0.02, and 0.17 \u00b1 0.03, respectively, after co-treatment with LPS and DCMF. M2 attenuated the expression of iNOS and NF-\u03baB to 0.18 \u00b1 0.03 and 0.17 \u00b1 0.03, respectively. Additionally, M3 attenuated the expression of iNOS to 0.18 \u00b1 0.03, and after co-treatment with M6 and LPS, the expression of COX-2 and NF-\u03baB was down-regulated to 0.2 \u00b1 0.03. Our study proves the immunomodulatory effect of Noni fruits and specifies for the first time the compounds responsible for their activity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232302435,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1039\/d0fo03402a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently, a training mannequin suitable for ophthalmic blocks has been developed. It provides a new feature of visual feedback to the trainee. A validation of the efficacy of this training system with needle angle visualization, ocular structure proximity, and procedural warning features was conducted in an evaluative study with 41 participants; 21 post graduate trainees and 20 ophthalmic consultants from a tertiary ophthalmic care facility in Chennai, India. The participant's performance was evaluated and analyzed using an appropriate scoring scheme in two sessions with and without visual feedback. The participants were also requested to provide feedback on the anatomical likeness and usage. A two tailed signed rank Wilcoxon test verified the statistical significance of the visual feedback (Pz(4.55, 0.05)= 0.9999, $P\\lt $0.001). The mean score of the participants showed an increase 58.86% and 25.5% for graduate trainee and consultants respectively and a mean reduction of 85.41% in the warning indications provided was also substantiated the efficacy of the visual feedback.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":61812009,"openaccessinfo":{"externalids":{"MAG":"2914171581","ACL":null,"DOI":"10.1109\/CIBEC.2018.8641833","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is critical to understand the behavior of metallic impurities in polycrystalline silicon used for solar cells. These impurities significantly increase the minority carrier recombination rate and, in turn, degrade cell performance. Impurity gettering is a commonly used method to remove these impurities from the material, however, past work has suggested that impurity release from structural defects drastically limits the gettering process. Presently, there is only a limited understanding of impurity release from structural defects. In this work, a correlation between structural defects and the location of metal impurities in as-grown material is established and the release of nickel and copper from structural defects in polycrystalline silicon was studied in as-grown material and after sequential thermal treatments which dissolve the impurities into the silicon matrix. Synchrotron-based x-ray fluorescence impurity mapping with spatial resolution of {approx} 1 {micro}m, was used to determine impurity distributions after each thermal treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":67833825,"openaccessinfo":{"externalids":{"MAG":"2010960751","ACL":null,"DOI":"10.2172\/515591","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/digital.library.unt.edu\/ark:\/67531\/metadc696114\/m2\/1\/high_res_d\/515591.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We present the case of a 22-year-old asthmatic woman, who had undergone high-pressure servo-ventilation as part of the therapy of an otherwise untreatable asthmatic attack. Ventilation-pressures reached peaks of 80 mg H2O while under relaxation and sedation arterial blood pressure fell to 50\/30 mm Hg. Treatment was complicated by pulmonary ruptures, pneumothorax and massive cutaneous emphysema. After successful completion of this treatment phase (day 14), the patient was allowed to regain consciousness and was found to be in a subtotal tetraplegic state: muscles of the neck, shoulders and left leg were slightly less atonic than others. Facial muscles, different qualities of sensitivity, intellectual functions and sense organs did not seem to be afflicted. Restitution of the tetraplegia was complete by day 50 of treatment, a neurological follow up six months after discharge from hospital showed no residual deficit. We hypothesize that the extreme ventilation-pressures together with the decrease of arterial blood-pressure have impaired the blood-flow in the system of the anterior spinal arteries. Together with concordant oedema this effected a localized dysfunction mainly of the ventral medullary areas corresponding to the functions of the anterior spino-cortical tract. Diagnostically we do not fully exclude steroid myopathia, but think in this case the cumulated steroid doses were too small and the course of remission indicates a localized haemodynamic lesion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37169454,"openaccessinfo":{"externalids":{"MAG":"2469574760","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The kinetics of shape evolution of a tetragonal precipitate coherently embedded in a cubic matrix are examined. Specifically, the morphology of tetragonal ZrO2 particles in partially stabilized cubic ZrO2 is discussed. A computer simulation, carried out without any a priori constraint on possible kinetic paths and particle morphologies, shows that a lenslike shape appears during growth of a tetragonal particle. Upon further coarsening, the shape relaxes into a rhombus bounded by facets. Depending on the balance between interfacial and strain energies controlled by the particle size, the facets can be smoothly curved or straight. The predicted particle morphologies are in good agreement with the experimental observations. The kinetic model proposed is quite general for simulating microstructural developments during decomposition involving a crystal lattice symmetry change where elastic strain accommodation plays an important role.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":28490142,"openaccessinfo":{"externalids":{"MAG":"1993977665","ACL":null,"DOI":"10.1111\/J.1151-2916.1993.TB06605.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study aims to reveal confidence in Islamic financial institutions as an institution that operates based on sharia principles to provide public welfare with four disclosure indicators, namely Islamic corporate social responsibility, Islamic corporate governance, zakah funds, and financial performance. This study elaborated path analysis calculations to gain a deep understanding on the provided issues. The population in this study included data on the publication of annual financial reports on Islamic banks in Indonesia which are registered with the Financial Services Authority (OJK) with a total of 14 Islamic banks, while the samples were selected according to the provisions of the purposive sampling method. The findings of this study indicate that partially Islamic, corporate social responsibility, Islamic corporate governance, and zakah funds have a positive and significant effect on financial performance. Also, Islamic corporate social responsibility and Islamic corporate governance have a positive and significant effect on financial performance through zakah funds.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":264887013,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.53787\/iconev.v2i1.3","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Trials have demonstrated that high-dose escalation followed by autologous transplantation can promote better long-term survival as salvage treatment in malignant lymphomas. The aim of the present nonrandomized clinical trial was to demonstrate the role of high-dose cyclophosphamide (HDCY) in reducing tumor burden and also to determine the effectiveness of HDCY followed by etoposide (VP-16) and methotrexate (MTX) in Hodgkin's disease plus high-dose therapy with peripheral blood progenitor cell (PBPC) transplantation as salvage treatment. From 1998 to 2000, 33 patients with a median age of 33 years (13-65) affected by aggressive non-Hodgkin's lymphoma (NHL) (60.6%) or persistent or relapsed Hodgkin's disease (39.4%) were enrolled and treated using high dose escalation (HDCY + HDVP-16 plus HDMTX in Hodgkin's disease) followed by autologous PBPC transplantation. On an \"intention to treat\" basis, 33 patients with malignant lymphomas were evaluated. The overall median follow-up was 400 days (40-1233). Thirty-one patients underwent autografting and received a median of 6.19 x 10(6)\/kg (1.07-29.3) CD34+ cells. Patients who were chemosensitive to HDCY (N = 22) and patients who were chemoresistant (N = 11) presented an overall survival of 96 and 15%, respectively (P<0.0001). Overall survival was 92% for chemosensitive patients and 0% for patients who were still chemoresistant before transplantation (P<0.0001). Toxicity-related mortality was 12% (four patients), related to HDCY in two cases and to transplant in the other two. HDCY + HDVP-16 plus HDMTX in only Hodgkin's disease followed by autologous PBPC proved to be effective and safe as salvage treatment for chemosensitive patients affected by aggressive NHL and Hodgkin's disease, with acceptable mortality rates related to sequential treatment.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2013-20":1,"unknown":2}},"corpusid":262239644,"openaccessinfo":{"externalids":{"MAG":"2098728735","ACL":null,"DOI":"10.1590\/S0100-879X2002000100007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This essay concerns the fundamental principles that will guide congressional deliberations regarding trade policy in the coming months and years. There is no question but that Congress must respond effectively to progressive social demands, such as demands that the environment not be sacrificed to an unbridled adherence to the concept of free trade. At the same time, Congress must not lose sight of certain fundamental principles that have guided U.S. trade policy since the Second World War. The underlying commitment of the United States to liberal trade policy is not based on a simplistic commitment to comparative advantage as an end in itself, but is deeply rooted in a commitment to democratic values. Although a persuasive textbook case might be made for managed trade, central government control over trade has consistently resulted in dramatic economic and social failure, or economic success coupled with social conditions that would be intolerable in the United States.The liberal trading system must become more responsive to the interests of the environment and human well-being. It is capable of being adapted to meet the demands of the twenty-first century. This essay offers a few modest suggestions as to how this goal might be accomplished. The central message of this essay, however, is that adherence to the underlying principles of the liberal trading system and the accomplishment of progressive social goals are not mutually exclusive. It is imperative that progressive social goals not be confused with the interests of industries that have failed to respond to international competition.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":155561676,"openaccessinfo":{"externalids":{"MAG":"2258344326","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to apply the formative aesthetic of human body to the form of clothing. For this purpose I try to find the various methods of analysis used in the work of sculpture. The method of inference and the checklists of design are used to relate the sculpture with the clothing design specifically. This methodology intends to regard human body as an artistic form and use the image of sculpture to the maximum. Especially I try to derive the motives of design and recreate them it clothing design emphasizing silhouette. On this methodology, following results were developed. First, the observations on the formative characteristic of human body show that the transformed form of human body expresses more perfect image of human body than the original form. The power of simplicity heightens the total beauty of the work. Second, the image of human body expressed in simplicity and exaggeration can be variously recreated in a silhouette with the formative and cubic effect, simplicity, and activity. Third, the elegant and static image found in the analysis and synthesis of human body can be used as a motive of clothing design and the changed details lead to the transformation of silhouette. Fourth, in developing designs by the item of checklists, one motive can be variously recreated according to the methods of designs.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":114485725,"openaccessinfo":{"externalids":{"MAG":"2567313231","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In non-rodent toxicity studies supporting pharmaceutical or chemical product registration, the value of histopathology evaluation of all tissues from all animals from all dose groups is an ongoing discussion topic among pathologists. This manuscript documents an examination of this topic through a retrospective review of internal nonclinical study data from non-rodent toxicity studies performed at three pharmaceutical companies (Abbott Laboratories, Eli Lilly, and Pfizer, Inc.) and an informal survey of the current practices within the toxicological pathology community. The retrospective review of 325 non-rodent studies in which all organs in all dose groups were examined revealed no evidence that risk assessment would have changed if only the control and high-dose animals and target organs only in intermediate dose groups had been examined. One study had target tissues in a lower-dose group that were not identified in the high-dose group; however, there was no impact on the overall study interpretation. The recently revised European Medicines Agency guideline regarding repeated-dose toxicity studies encourages the examination of all tissues at all dose levels in non-rodent studies. In conclusion, the evaluation of all tissues from all animals may not be justified as a routine practice; however, regulatory guidance with input from toxicologic pathologists will influence these policy decisions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36403030,"openaccessinfo":{"externalids":{"MAG":"2171893574","ACL":null,"DOI":"10.1177\/0192623312439642","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623312439642","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The ability to fundamentally describe nanoparticle (NP) transport in the subsurface underpins environmental risk assessment and successful material applications, including advanced remediation and sensing technologies. Despite considerable progress, our understanding of NP deposition behavior remains incomplete as there are conflicting reports regarding the effect of fluid flow velocity on attachment efficiency. To directly address this and more accurately describe NP attachment behavior, we have developed a novel protocol using a quartz crystal microbalance with dissipation monitoring (QCM-D) to separate and individually observe deposition mechanisms (diffusion and sedimentation), providing in situ, real-time information about particle diffusion (from the bulk liquid to solid surface). Through this technique, we have verified that the approaching velocity of NPs via diffusion increases (0.8-6.7 \u03bcm\/s) with increasing flow velocity (6.1-106.0 \u03bcm\/s), leading to an increased NP kinetic energy, thus affecting deposition processes. Further, in the presence of a secondary energy minimum associated with organic surface coatings, secondary minimum deposition decreases and primary minimum deposition increases with the flow velocity. NPs deposited at the primary minimum are relatively more resistant to hydrodynamic energies (including detachment associated energies), resulting in an increase of observed attachment efficiencies. Taken together, this work not only describes a novel method to delineate and quantify physical processes underpinning particle behavior but also provides direct measurements regarding key factors defining the relationship(s) of flow velocity and particle attachment. Such insight is valuable for next-generation fate and transport model accuracy, especially under unfavorable attachment regimes, which is a current and critical need for subsurface material applications and implication paradigms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":222421659,"openaccessinfo":{"externalids":{"MAG":"3092705793","ACL":null,"DOI":"10.1021\/acs.est.0c02669","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The theory of the magnetic circular dichroism (MCD) of cyclic re-electron systems with 4 N \u00b1 1 electrons, such as the radical anion of [16] annulene, has been investigated in the perimeter model approximation. General solutions and formulas for the calculation of the Faraday parameters A, B, and C are derived analytically. The calculated and measured spectra of the 17 \u03c0-electron [16] annulene radical are in good agreement.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":96340625,"openaccessinfo":{"externalids":{"MAG":"2018214216","ACL":null,"DOI":"10.1515\/zna-1993-1217","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/zna-1993-1217\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Fast semiconductor radiation detectors operated in current mode provide a valuable diagnostic in pulsed power applications. Si detectors are common due to the availability of high-quality materials and mature fabrication processes, but they offer low absorption for hard x-rays above \u223c10 keV. GaAs can provide increased hard x-ray absorption for the same detector volume due to a higher atomic number. GaAs photodiodes have been produced from epitaxial material grown at Sandia National Laboratories and fabricated at Sandia's microfabrication facility. These detectors have significantly higher hard x-ray absorption (>10\u00d7 at 15 keV) and nearly identical temporal impulse response to similarly sized Si detectors of 0.5 ns full-width half maximum.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208356353,"openaccessinfo":{"externalids":{"MAG":"2988338866","ACL":null,"DOI":"10.1063\/1.5127294","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/aip.scitation.org\/doi\/10.1063\/1.5127294","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"As microelectromechanical systems (MEMS) move rapidly towards commercialization, the issue of mechanical characterization has emerged as a major consideration in device design and fabrication. It is now common to include a set of test structures on a MEMS wafer for extraction of thin film material properties (in particular, residual stress, stress gradient and Young's modulus), and for process and device monitoring. These structures usually consist of micromachined beams and strain gauges. Measurement techniques include tensile testing, scanning electron microscopy (SEM) imaging, atomic force microscopy (AFM) analysis, surface profiling and Raman spectroscopy. However, these tests are often destructive and may be difficult to carry out at the wafer scale. Instead of these methods, this paper uses white-light interferometry surface profiling for material characterization and device inspection. Interferometry is quick, non-destructive, non-contact, and can offer a high density lateral resolution with extremely high sensitivities to the surface in the z-direction\u2014all essential requirements for high volume manufacturing. A range of devices is employed to illustrate the capabilities of white-light interferometry as a measurement and process characterization tool. It is shown that residual stress may be determined by using electrostatic actuation to pull fixed\u2013fixed beams towards the substrate, and interferometry to record the beam deflection profile. Finite-element simulation software is employed to model this deflection, and to estimate the material properties which minimize the difference between the measured and simulated profiles. The results agree well with blanket film measurements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250880031,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0957-0233\/14\/10\/310","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A plethora of bat-associated lyssaviruses potentially capable of causing the fatal disease rabies are known today. Transmitted via infectious saliva, occasionally-reported spillover infections from bats to other mammals demonstrate the permeability of the species-barrier and highlight the zoonotic potential of bat-related lyssaviruses. However, it is still unknown whether and, if so, to what extent, viruses from different lyssavirus species vary in their pathogenic potential. In order to characterize and systematically compare a broader group of lyssavirus isolates for their viral replication kinetics, pathogenicity, and virus release through saliva-associated virus shedding, we used a mouse infection model comprising a low (102 TCID50) and a high (105 TCID50) inoculation dose as well as three different inoculation routes (intramuscular, intranasal, intracranial). Clinical sings, incubation periods, and survival were investigated. Based on the latter two parameters, a novel pathogenicity matrix was introduced to classify lyssavirus isolates. Using a total of 13 isolates from ten different virus species, this pathogenicity index varied within and between virus species. Interestingly, Irkut virus (IRKV) and Bokeloh bat lyssavirus (BBLV) obtained higher pathogenicity scores (1.14 for IRKV and 1.06 for BBLV) compared to Rabies virus (RABV) isolates ranging between 0.19 and 0.85. Also, clinical signs differed significantly between RABV and other bat lyssaviruses. Altogether, our findings suggest a high diversity among lyssavirus isolates concerning survival, incubation period, and clinical signs. Virus shedding significantly differed between RABVs and other lyssaviruses. Our results demonstrated that active shedding of infectious virus was exclusively associated with two RABV isolates only (92 % for RABV-DogA and 67 % for RABV-Insectbat), thus providing a potential explanation as to why sustained spillovers are solely attributed to RABVs. Interestingly, high-resolution imaging of a selected panel of brain samples from bat-associated lyssaviruses demonstrated a significantly increased percentage of infected astrocytes in mice inoculated with IRKV (10.03 %; SD\u00b17.39) compared to RABV-Vampbat (2.23 %; SD\u00b12.4), and BBLV (0.78 %; SD\u00b11.51), while only individual infected cells were identified in mice infected with Duvenhage virus (DUVV). These results corroborate previous studies on RABV that suggest a role of astrocyte infection in the pathogenicity of lyssaviruses. Author Summary Globally, there are at present 17 different officially recognized lyssavirus species posing a potential threat for human and animal health. Bats have been identified as carriers for the vast majority of those zoonotic viruses, which cause the fatal disease rabies and are transmitted through infectious saliva. The occurrence of sporadic spillover events where lyssaviruses are spread from bats to other mammalian species highlights the importance of studying pathogenicity and virus shedding in regard to a potentially sustained onward cross-species transmission. Therefore, as part of this study, we compared 13 different isolates from ten lyssavirus species in a standardized mouse infection model, focusing on clinical signs, incubation periods, and survival. Based on the latter two, a novel pathogenicity index to classify different lyssavirus species was established. This pathogenicity index varied within and between different lyssavirus species and revealed a higher ranking of other bat-related lyssaviruses in comparison to the tested Rabies virus (RABV) isolates. Altogether, our results demonstrate a high diversity among the investigated isolates concerning pathogenicity and clinical picture. Furthermore, we comparatively analyzed virus shedding via saliva and while there was no indication towards a reduced pathogenicity of bat-associated lyssaviruses as opposed to RABV, shedding was increased in RABV isolates. Additionally, we investigated neuronal cell tropism and revealed that bat lyssaviruses are not only capable of infecting neurons but also astrocytes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238261217,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pntd.0009845","PubMedCentral":"8797209","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosntds\/article\/file?id=10.1371\/journal.pntd.0009845&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Copper(II) is one of the essential metal elements in human body, which can accumulate in many organs and finally excrete in urine. Excessive load of Cu2+ can cause liver cirrhosis, kidney dysfunction, and many neurological symptoms in the case of Wilson's disease (WD). Therefore, the selective and efficient detection of Cu2+ is of great importance. Although various fluorescent probes have been reported for the detection of Cu2+, an efficient and capable probe is still rare for patients' self-use on a routine basis. In this study, we developed an easy-to-use probe CY1 based on UV-vis-near-infrared absorption changes with excellent sensitivity and selectivity for Cu2+. The mechanism of oxidation of CY1 by Cu2+ was first explored. We demonstrated the role of the probe in the quantitative detection of Cu2+ in urine from WD patients and showed that it has great potential for clinical applications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44104209,"openaccessinfo":{"externalids":{"MAG":"2805062127","ACL":null,"DOI":"10.1021\/acsami.8b07081","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A four-stage power amplifier (PA) covering 55\u201367GHz band is presented. The broadband performance is achieved owing to \u03c0-section interstage matching network. Three-stage-current-reuse topology is proposed to enhance efficiency. The amplifier has been fabricated in 65 nm digital CMOS. 18 dB power gain and 9.6 dBm saturated power (Psat) are achieved at 60GHz. The PA consumes current of 52 mA at 1.2 V supply voltage, and has a peak power-added efficiency (PAE) of 13.6%. To the best of the authors' knowledge, this work shows the highest PAE among the reported CMOS PAs with less-than-1.2 V supply voltage and covering the worldwide 9GHz millimeter-wave band.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15222911,"openaccessinfo":{"externalids":{"MAG":"2124861452","ACL":null,"DOI":"10.1109\/RFIC.2011.5940686","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background and Aims: Men who have sex with men (MSM) are vulnerable to contracting HBV as a sexually transmitted infection. We evaluated the incidence of HBV infection (HBI) and the prophylactic effect of tenofovir-based pre-exposure prophylaxis (PrEP) on HBI in an MSM cohort. Methods and Results: MSM who were older than 16 years were enrolled from January 2018 and followed up until June 2021 and tested for HIV, bacterial sexually transmitted infections, and HBsAg\/ HBsAb and HBcAb every 3 months based on inclusion criteria, including HBsAg, HBcAb, HBsAb, and HIV negativity at enrollment. HBI was defined as seroconversion of HBsAg or HBcAb status. The log-rank test was used to evaluate the prophylactic effect of PrEP against HBI. As a substudy, individuals excluded from the main study due to HBs Ab positivity were evaluated for HBI incidence. Among 1577 MSM, 786 participants (546 PrEP nonusers, 131 daily PrEP users, and 109 event-driven PrEP users) met the criteria and were included. The annual incidence of HBV among PrEP nonusers (3.8%, 21 infections, with 559.5 person-years) was significantly higher (p = 0.018, log-rank test) than that among daily PrEP users [0.77%, 1 infection (admitted nonadherence), with 129.3 person-years] and event-driven PrEP users (no infection with 93.8 person-years). Although the incidence of HBI and HIV infection decreased with PrEP use, the incidence of other sexually transmitted infections was higher in both daily and event-driven PrEP users. The annual incidence of HBV among HBsAb-positive and HBcAb-negative PrEP nonusers was 1.8% (3 infections, with 167.5 person-years). Conclusions: Tenofovir-based PrEP prevented HBI among MSM in a real-world setting.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257717035,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/HEP.0000000000000384","PubMedCentral":"10187616","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Zhurkov's 'equation for polymer life' (1965) is used to evaluate dipole moments from electrical breakdown data. While that for PET compares with conventional values, that for PE does not. The discrepancy is shown to be due to the electromechanical compression of the PE, which exists in the rubbery phase under the conditions of measurements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250754005,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/13\/1\/006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The dry powdered of Sinapis arvensis, Thymelaea hirsuta, Callistemon lanceolatus and Peganum harmala showed molluscicidal activity against Biomphalaria alexandrina, specific intermediate hosts to Schistosoma mansoni. Effect of LC25 of dry powdered plant molluscicides on hexokinase (HK), glucose phosphate isomerase (GPI), AMP deaminase, adenosine deaminase and phenol oxidase (PO) of B. alexandrina was traced. C. lanceolatus showed the highest molluscicidal activity as it has the lowest LC50 compared to S. arvensis, T. hirsuta, and P. harmala. LC25 of the latter three plants resulted in more significant inhibition of HK, GPI, AMP-deaminase and PO than C. lanceolatus. Treatment of snails with LC10 of these plants markedly affected compatibility of B. alexandrina to S. mansoni infection. Significant decrease in cercarial production recorded in snails treated with sublethal concentrations of S. arvensis, T. hirsuta, and P. harmala. Remarkable impairment of the egg laying capacity of molluscicide-treated snails was also recorded. Correlation between activity levels of HK, GPI and AMP deaminase and compatibility to parasitic infection and role of PO in the egglaying capacity of these snail species were discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27467262,"openaccessinfo":{"externalids":{"MAG":"2405245789","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nThe purpose of this study was to determine whether a correlation exists between passing the United States Medical Licensing Examination (USMLE) Step 1 (USMLE) on the first attempt and performance on National Board Dental Examination Part I (NBDE).\n\n\nMATERIALS AND METHODS\nQuestionnaires were sent to program directors of 52 dual-degree oral and maxillofacial surgery programs. The information requested concerned residents of each program from 1990 to 2000 and included NBDE scores and number of attempts each resident took to pass the USMLE Step 1. Also included was the number of years of medical school each program required, as well as time given to USMLE Step 1 study preparation. The data were analyzed to determine if a relationship exists between NBDE Part I score and pass rate on the USMLE Step 1 on the first attempt. Data presented are the mean +\/- SD.\n\n\nRESULTS\nQuestionnaires were received from 26 of 52 (50%) dual-degree oral and maxillofacial surgery programs regarding 426 residents. The overall average of NBDE Part 1 was 92.55 +\/- 3.62 (range, 83 to 99). The average NBDE Part I score for those candidates who passed the USMLE Step 1 on the first attempt was 93.75 +\/- 3.02, and for those who did not pass the USMLE Step 1 on the first attempt, it was 89.12 +\/- 2.93. The average NBDE Part I score is significantly higher for those subjects who passed the USMLE Step 1 on the first attempt (P <.001). A candidate with an NBDE Part I score of 95 to 99 is 75 times more likely to pass the USMLE Step 1 on the first attempt than is a candidate with a score of less than 90. A marginal association was found with study preparation time and amount of medical school completed during residency.\n\n\nCONCLUSIONS\nA significant correlation exists between NBDE Part I score and pass rate on the USMLE Step 1 examination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23910001,"openaccessinfo":{"externalids":{"MAG":"2133642536","ACL":null,"DOI":"10.1053\/JOMS.2003.50140","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Immune checkpoint inhibitor (ICI)-induced colitis is one of the known complications of therapies targeting cytotoxic programmed cell death protein 1 (PD-1), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and programmed cell death ligand 1 (PD-L1). ICI-associated colitis is routinely treated with immunosuppressive therapy, including corticosteroids and\/or agents targeting tumor necrosis factor-\u03b1 (TNF-\u03b1). In this report, a 69-year-old male patient developed severe ICI-induced colitis 2 weeks after anti-PD-L1 mAb (i.e., durvalumab) treatment; unexpectedly failed to respond to systemic corticosteroid, anti-TNF, and anti-integrin agents; and unfortunately died in 1 month. This case reminds clinical physicians to be on the alert for early-onset acute ICI-induced colitis and emphasizes that urgent optimized rescue measures are required for patients with severe ICI-induced colitis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249997003,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fonc.2022.925964","PubMedCentral":"9259980","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2022.925964\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Teenagers aren't much into following serious news online, but news organizations can ? and should ? cultivate their interest by learning how to catch their eyes, diminish their angst, go where they are on the Web, enlist parents and teachers in the cause and help them develop a news persona, according to this report. The report is based on a qualitative, in-depth study of 65 Chicago-area teens conducted in 2007 by Media Management Center. The purpose was to identify what drives online news consumption of teenagers. Researchers found that while serious news ? particularly news of politics, government and public affairs ? is not currently that important to most teens, they are \"interestable.\" They will look at news online if it catches their eye ? with content that interests them, video, the right topics, humorous and weird news, and new things. The report urged news organizations to make \"catching the eye\" of teenagers the core of a bold new strategy for attracting teens online; to \"work over time to fan whatever sparks of interest they may have in news into a more robust flame of interest in various types of news,\" and to \"make a special effort to encourage ? and even increase the number of ? teens who consider it part of their identity to follow and talk about the news.\"","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":154432986,"openaccessinfo":{"externalids":{"MAG":"2136835602","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pseudomonas aeruginosa is a Gram-negative bacillus associated with waterborne diseases. The objective of this study was to determine whether particular P. aeruginosa sequence types (STs) were associated with drinking water contamination in Brazil. This was achieved by searching the Pseudomonas PubMLST database which contains the records for 8358 strains collected between 1938-2023. The majority (97.2%) had the complete 7-loci multilocus sequence typing profile and were assigned to 3,486 STs. After eBURST (an algorithm used to infer patterns of evolutionary descent among clusters), 1,219 groups with single-locus variant and 575 groups with double-locus variant were formed. Brazil was the South American country with the most isolates (n=219, 58.24%), and the Simpson`s index was 0.9392. Of the 219 Brazilian isolates, eight were isolated in water and identified as STs 252, 1417, 1605, 2502, 2620, 3078 and 3312. ST252, 1417 and 3078 have already been isolated from clinical cases worldwide. Furthermore, ST1605 and 2620, after the eBURST, they were grouped in the same clonal complex as STs involved in human infections. In conclusion, P. aeruginosa STs involved in human infections were found in bottled drinking water commercialized in Brazil, revealing that these types of drinking waters can be a vehicle of contamination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262148233,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/lambio\/ovad109","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Glycyl-adenylate is the simplest model for understanding the central role played by amino- acyl-adenylates in the protein synthesis, and may be also in the prebiotic evolution. Optimized conformation of glycyl-adenylate (GlyAMP), in vacuum, was determined using ab initio RHF\/6\u201331Gdp computations. GlyAMP in vacuum (form corresponding to neutral pH conditions) possesses a specific conformation of the glycyl-phosphate stem with a double seven membered ring that results from the electrostatic interaction between the anionic phosphate and the cationic ammonium. This structure is explained on the basis of the theoretical infrared vibrational spectrum and discussed with regard to those of glycyl-adenylate (GAP1550 and GAP2550 forms) in the active pockets of glycyl-tRNA synthetase. The electrostatic properties of these different conformations are presented, and the influence of the charged residues (anionic GLU188, GLU239, GLU359, and cationic ARG220) and Mg++, in interaction with GAP1550 are discussed, taking into account the computation of the electronic chemical potential, the electron affinity and the electrophilic index.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":810337,"openaccessinfo":{"externalids":{"MAG":"1971593246","ACL":null,"DOI":"10.1080\/07391102.2008.10507215","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The luminescence of AgBr, AgCl, and AgClBr crystals and fibers doped with Pr3+ ions was investigated in the middle-infrared spectral range. We measured the absorption, emission, and kinetic parameters over a broad temperature range. Strong luminescence in the spectral range 4-5.5 microm was observed for the first time to our knowledge in silver halide crystals and fibers at room temperature. No noticeable differences were observed between the crystals and the fibers. We calculated various optical parameters for Pr:AgBr and Pr:AgCl crystals, using the Judd-Ofelt approximation. Both the measured results and the calculated parameters indicate that these doped crystals and fibers would be good candidates for the fabrication of mid-IR solid-state lasers or fiber lasers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23164395,"openaccessinfo":{"externalids":{"MAG":"2064087319","ACL":null,"DOI":"10.1364\/OL.30.001831","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two similar cases of tonal monaural diplacusis are described. When low\u2010intensity sinusoids within a certain range are presented, several distinct tones are heard in addition to the tone presented. The effects are focussed at 3610 cps for one subject and at 3155 cps for the other. Pitch\u2010matching and probe\u2010tone techniques show that the additional tones correspond to combination tones expected in a normal ear stimulated by two tones, one of which is fixed at one of the above frequencies. Hence some basic instability of the auditory mechanism at these frequencies is indicated for these observers. It is suggested that the defect lies in the \"peaking\" process of the cochlea, so that an adequate explanation of the phenomena may be of some importance to auditory theory.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":122094379,"openaccessinfo":{"externalids":{"MAG":"2156545448","ACL":null,"DOI":"10.1121\/1.1907529","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The exact solving of the continuum radial wave equation for the one-electron two-centre problem is achieved through the characteristic exponent parameter which is determined in a rigorous way by a simple mathematical method. Its derivative with respect to the intercentre distance R involved in matrix elements calculations between discrete and continuum states is also given. Illustrative results are presented for several states of , for up to 10 and for and momentum K = 1 au. As an example, the calculated expansion coefficients of the radial continuum wavefunctions expressed in series of the Legendre functions of the first kind with separated exponent are given for the state of . Representative curves of the separation constant as well as the characteristic exponent are displayed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120288690,"openaccessinfo":{"externalids":{"MAG":"1985874262","ACL":null,"DOI":"10.1088\/0953-4075\/29\/5\/013","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Dispersions of CdS powder with or without metal or metal oxide deposits, such as Pt, Au, Ag, Rh, Rh2O3 and RuO2, have been used to sensitise the oxidation of water by PtCl2\u20136. The most active of the CdS-based photosensitisers was found to be one in which Pt was deposited by precipitation of a Pt colloid onto the surface of a CdS sample which had been annealed in air for 3 h prior to platinisation. A study was made to determine the optimum conditions for O2 evolution. The initial rate of O2 evolution was found to depend upon a number of factors including: pH, [CdS\/Pt], [PtCl2\u20136], [O2], Pt loading and CdS annealing temperature and environment. Although a number of different electron acceptors were tried, including PtCl2\u20136, PtCl2\u20134, Pt(OH)2\u20136, H2AuO\u20133, S2O2\u20138, Co(NH3)5Cl2+ and Fe(CN)3\u20136, O2 photogeneration was observed with only PtCl2\u20136 and Fe(CN)3\u20136. A number of other materials were tested as photocatalysts for the oxidation of water by PtCl2\u20136, including TiO2, TiO2\/Pt, TiO2\/Rh2O3, CdO, CdO\/Pt, HgS\/Pt, SiO2\/Rh2O3 and Al2O3\/Pt; however, only the TiO2-based materials showed any activity. The results of this work are discussed with respect to the current controversy over the mechanism for O2 evolution.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97884901,"openaccessinfo":{"externalids":{"MAG":"2140733418","ACL":null,"DOI":"10.1039\/F19898500503","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A generation ago, such a book as this would have been not only a rarity but a treasure. We starry-eyed graduates thought of medicine as a calling to serve man, not Mammon. We had no courses in medical economics, no free magazines telling us that we ought to buy more equipment to handle more customers and to hire more aides to increase our income; no time was spent on figuring out what it cost to see the average patient (all expenses divided by the number of patients seen on an average day with a load factor tossed in and \"x\" equalling the magic figure that we must attain, or fail as medical businessmen); we did not use charge slips to be sure to itemize every fee for each little service\u2014and look like department store sales clerks while doing so; we did not interpose office girls between all contacts with patients","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":57936062,"openaccessinfo":{"externalids":{"MAG":"1968564541","ACL":null,"DOI":"10.1001\/ARCHINTE.1965.03860130120043","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, the influence of flame treatment on the surface properties of polypropylene (PP) and thermoplastic polyolefins with talc and carbon black filler (TPO), and adhesion of the ap -plied coating in the conditions of industrial robotic dyeing process were investigated. The flame treatment was carried out at two distances from the flame (7.5 cm and 12.5 cm) at constant air and methane flows as well as speed of the burner. The thermal stability of untreated samples was investigated using thermogravimetric analysis (TGA). The change in thermal properties before and after flame treatment was investigated using differential scanning calorimetry (DSC). Changes of the samples' surface energy were examined before flame treatment, 1 h and 24 h after flame treatment, by the contact angle method. Qualitative analysis of the surface chemical composition, before and after flame treatment, was performed by ATR \u2013 FTIR analysis, and morphological changes by scanning electron microscopy (SEM). After applying the base layer, dye and topcoat on the surface of the treated samples, the adhesion was determined by standard methods ISO 2409 and ISO 16925\/D25 2018-B. The results showed that TPO containing talc and carbon black filler have better thermal stability compared to PP. Flame treatment influenced the surface character -istics of the samples, namely the increase in surface free energy and the appearance\/structure of the surface. With ATR \u2013 FTIR, the existence of polar groups on the surface after flame treatment were determined. According to the standards, all dyed samples met the requirements of excellent adhesion on the substrate\/coating interface.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":243535008,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15255\/kui.2020.072","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.15255\/kui.2020.072","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The term \" Gargoyle\" was introduced by Ellis, Sheldon, and Capon in 1936. The condition was first recognized by Thomson in 1900, but his original cases were not reported until later (Henderson and Ellis, 1940). Although about 200 cases have been reported, there are few detailed studies of the cardiovascular system. Necropsy material is rare, and has been reviewed by Strauss (1948) and Lindsay (1950). Since then other necropsies have been reported by Jervis (1950), Magee (1950), Henderson et al. (1952), Millman et al. (1952), Schwarz (1952), and Smith et al. (1952), making a total of 32 in all. The following observations were made on two brothers, both with gargoylism, who were studied during life and found to have cardiovascular involvement. One died and the post-mortem findings are reported.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26481762,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell replacement therapy. First-in-human trials, in particular, raise a number of ethical concerns including informed consent, subject recruitment and harm minimisation as well as the inherent uncertainty and risks which are involved in testing medical procedures on humans for the first time. These issues, while a feature of any human research, become more complex in the case of iPS cell therapy, given the seriousness of the potential risks, the unreliability of available animal models, the vulnerability of the target patient group, and the high stakes of such an intensely public area of science. Our paper will present a detailed case study of iPS cell replacement therapy for Parkinson's disease to highlight these broader ethical and epistemological concerns. If we accept that iPS cell technology is fraught with challenges which go far beyond merely refuting the potentiality of the stem cell line, we conclude that iPS cell research should not replace, but proceed alongside embryonic and adult somatic stem cell research to promote cross-fertilisation of knowledge and better clinical outcomes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205565205,"openaccessinfo":{"externalids":{"MAG":"1854922002","ACL":null,"DOI":"10.1111\/j.1467-8519.2011.01896.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/j.1467-8519.2011.01896.x","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Purpose - The purpose of the paper is to report the findings of a Swedish national survey study finalised in late 2010. The purpose of the project was to create a picture of Swedish library services directed to the five minority groups defined as \"national minorities\" in the country: Romani, Sami, Jews, Tornedalians and Swedish Finns. The study focuses on media, cultural activities, and co-operation. Design\/methodology\/approach - In the study, a survey questionnaire was used as the primary method. The questionnaire was sent to all 289 county libraries of Sweden. A total of 181 were returned and used in the study. The theoretical stance is emancipatory in that it takes the position that libraries may play a vital role not only for the social integration of the concerned minority groups, but also for spreading interest in, and understanding of, the unique identities of these groups in the majority society. Findings - The findings of the study show that Swedish public libraries have very limited services towards the national minority groups in focus. In some cases, like service to the elderly and out-reach activity, no activity whatsoever could be measured. Originality\/value - The research reported in the article is original in that it is the first time that the services to the national minority groups of Sweden are mapped and measured at a national level. The value of the result is high as it shows major weaknesses in library services and the study provides a good point of departure for developing minority services in Swedish libraries.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":155384252,"openaccessinfo":{"externalids":{"MAG":"2188485695","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"At present, the deep end-to-end method based on supervised learning is used in entity recognition and dependency analysis. There are two problems in this method: firstly, background knowledge cannot be introduced; secondly, multi granularity and nested features of natural language cannot be recognized. In order to solve these problems, the annotation rules based on phrase window are proposed, and the corresponding multi-dimensional end-to-end phrase recognition algorithm is designed. This annotation rule divides sentences into seven types of nested phrases, and indicates the dependency between phrases. The algorithm can not only introduce background knowledge, recognize all kinds of nested phrases in sentences, but also recognize the dependency between phrases. The experimental results show that the annotation rule is easy to use and has no ambiguity; the matching algorithm is more consistent with the multi granularity and diversity characteristics of syntax than the traditional end-to-end algorithm. The experiment on CPWD dataset, by introducing background knowledge, the new algorithm improves the accuracy of the end-to-end method by more than one point. The corresponding method was applied to the CCL 2018 competition and won the first place in the task of Chinese humor type recognition.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":220403344,"openaccessinfo":{"externalids":{"MAG":"3041199635","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2007.03860"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Current signal recording and processing systems have come a long way since their initial inception and use. There is, however, still ample scope for improvement, not only in the troubleshooting of their limitations, but also in the expansion of the boundaries in the recording of intracardiac signals. Here, we recount our experience with the use of the PURE EP\u2122 signal recording system (BioSig Technologies, Inc., Minneapolis, MN, USA) in the animal laboratory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":49357355,"openaccessinfo":{"externalids":{"MAG":"2615821483","ACL":null,"DOI":"10.19102\/icrm.2017.080407","PubMedCentral":"7252935","ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.19102\/icrm.2017.080407","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Tree houses are no longer just for children. With the growing excitement surrounding tree house architecture, adults around the world are building their own treetop hideaways -- savoring the childhood memories, feelings of nostalgia, and images of fantasy that are evoked by these almost dreamlike constructions. TreeHouses: Living a Dream brings together the most innovative ideas of today' s architects and designers, providing readers with a comprehensive exploration of the unique construction methods that allow these amazing structures to adapt to their changing environments. From Nebraska and Georgia to France and Germany, this book features a variety of projects that include playrooms, weekend retreats, home offices, dining rooms, and more. Each case study includes interior and exterior photography, as well as detailed site and floor plans accompanied by concise, informative text. With more than 350 full-color illustrations, TreeHouses: Living a Dream is sure to help every reader make a reality out of their tree house fantasy.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":106469236,"openaccessinfo":{"externalids":{"MAG":"638357378","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of the study was to determine whether rinsing with a mouthwash after brushing with a fluoridated toothpaste affected oral fluoride (F) retention and clearance compared with an oral hygiene regime without mouthwash. In this supervised, single-blind study, 3 regimes were compared: (A) brushing for 1 min with 1 g of 1,450 \u03bcg F\/g NaF toothpaste followed by rinsing for 5 s with 10 ml water; (B) as A but followed by rinsing for 30 s with 20 ml of 100 mg F\/l NaF mouthwash, and (C) as B but rinsing for 30 s with a non-fluoridated mouthwash. Twenty-three adults applied each treatment once in a randomised order, separated by 1-week washout periods, and used a non-fluoridated toothpaste at home prior to and during the study. Whole saliva samples (2 ml), collected before each treatment commenced and 10, 20, 30, 60, 90 and 120 min afterwards, were subsequently analysed for fluoride by ion-specific electrode. The mean (SD) back-transformed log (area under salivary F clearance curve) values were: A = 2.36 (+3.37, \u20131.39), B = 2.54 (+2.72, \u20131.31) and C = 1.19 (+1.10, \u20130.57) mmol F\/l \u00d7 min, respectively. The values for regimes A and B were statistically significantly greater than that for regime C (p < 0.001; paired t test). These findings suggest that use of a non-F mouthwash after toothbrushing with a F toothpaste may reduce the anticaries protection provided by toothbrushing with a F toothpaste alone. The use of a mouthwash with at least 100 mg F\/l should minimise this risk.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":7931735,"openaccessinfo":{"externalids":{"MAG":"1989102456","ACL":null,"DOI":"10.1159\/000239753","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This article introduces the reader to the role of music in a salutogenic approach to health, focusing on lay musical practice in public health policy and mental health promotion. Several participants reported how they used music as an alternative to medication or medical treatment, often transcending pain and suffering through personal, musical practices. The participants described how musicking can enhance coping mechanisms, providing a sense of coherence and zest for life, for example how using music may activate individuals in difficult periods in their lives, and retrieve or mobilise a stronger self. Individuals have learned how listening, playing and singing for self or others can be used as a 'technology' to achieve a sense of wholeness in body and mind, often described as 'musicking'. According to mood, context, need or situation, it is the combination of musical practices, properties and activities that tends to produce a personal or social healing effect.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1}},"corpusid":144605718,"openaccessinfo":{"externalids":{"MAG":"2044642631","ACL":null,"DOI":"10.1080\/14623730.2010.9721809","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Aggression is common in Huntington's disease. However, at present there are no standard guidelines for managing aggression in Huntington's sufferers due to a lack of empirical research. This paper presents a case study of the treatment of very high levels of aggression with sensory modulation and behaviour support intervention in a Huntington's sufferer. The client exhibited a range of aggressive behaviours, including physical aggression to people, furniture and objects, and verbal aggression. Following an eight week baseline phase, five weeks of sensory modulation intervention were employed. A behaviour support plan was then implemented as an adjunct to the sensory intervention, with aggressive behaviour systematically audited for a further 11 weeks. The results indicate a significant reduction in reported levels of aggression during the combined sensory modulation and behaviour support phase, compared to both the baseline and the sensory modulation therapy alone phases. This case study highlights the efficacy non-pharmacological interventions may have for reducing aggression in HD.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":4231468,"openaccessinfo":{"externalids":{"MAG":"2193846190","ACL":null,"DOI":"10.1080\/09602011.2015.1091779","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Thirdly, the evidence from Brixton prison appears to support the alleged connexion between natural homosexuality and sexual perversion, which is the view put forward by Sir Norwood East and W. H. Hubert2 and Clifford Allen,4 and opposed by Havelock Ellis and others. J. A. Symonds (in an unpublished essay) admits that, although \" a far larger proportion of mental disturbance and nervous hypersensitivity can he proved in Urnings than in normal men, in a vast majority of cases the Urning owing to present laws and social prejudices cannot, like other men, obtain a simple and easy satisfaction of his inborn sexual desires, which for him are as natural as swimming to a fish. It is this forcible suppression of an instinct so deeply rooted in his nature which originates the morbid symptoms that may often be observed in the Urning.\" The same author attributes to homosexual fears *and guilt \" at least half of the suicides of young men.\" Bernard Shaw has stated categorically that \" homosexuality implies no general depravity whatever.\"5 The validity of evidence to the contrary which might be drawn from the present series of cases is dependent entirely upon the support of a series of controls. An examination of the 198 prisoners (presumably males) charged with heterosexuial offences during the same period would probably yield a percentage of degeneracy comparable with that found in the homosexual group, and this again is valuable evidence that should be available before discussion can proceed with profit. But in any case it would be as unreasonable to draw conclusions about clinical and social (as distinct from antisocial) homosexuality from a series of homosexual prisoners as to base arguments concerning normal heterosexuality on the findings in a similar group of heterosexual offenders. General deductions as to treatment would be open to the same error. It would be as unlikely that patients from this series of cases could respond to psychotherapy by making a good social adaptation (even if their homosexuality were left untouched) as that their heterosexual fellow prisoners could be educated to become happy fathers and husbands. Only the dregs of both classes find their way into the prisons, anU unfortunately it is only from this group that statistical evidence about homosexuality can be collected. This evidence is not applicable to the socially adapted natural invert. Lastly, may the opportunity be taken to correct an error that appeared in the B.M.J. last year, and which still stands u(rchallenged, namely-that \" buggery \" is a scriptural term? The appellation of bougre (Fr: Bulgarian) was given to the ultrapuritanical sect of the Albigenses in the South of France during, the eleventh century A.D. on account of their association with the Bogomils, or Bulgarian heretics-heretics only by reason of their steadfast and unyielding opposition to Catholic orthodoxy, for which the sect was exterminated in the Albigensian \" Crusade \" of 1209.' The imputation of unnatural vice (which has been entirely discredited) was the invention of the fertile mind of Pope Innocent III, who was himself a repressed homosexual and a fanatical persecutor of all forms of sexual heterodoxy real or imagined. Cornwall. D. STANLEY-JONES. REFERENCES lAnomaly, The Invert, 1929, London; Stanley-Jones, D., Proc. roy. Soc. Med., 1947, 40, 590. 2Report on the Psychological Treatment of Crime, 1939, H.M.S.O., London. 3Bennet, E. A., British Medical Journal, 1946, 1, 289, 450; Rosanoff, A. J., Manual of Psychiatry, 7th ed., 1938, p. 556, New York; Quoted by Dillon, F., British Medical Journal, 1946, 1, 450; Stantey-Jones, D., Lancet, 1947, 1, 366. 4The Sexual Perversions and Abnormalities, 1940, London. 5 Personal communication, 1947. 6 Stanley-Jones, D., Med. Pr., 1946, 215, 391.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30069320,"openaccessinfo":{"externalids":{"MAG":"1990411473","ACL":null,"DOI":"10.1136\/bmj.2.4529.672","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc2056384?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The period 1997-2000 saw a rapid global consolidation of crop seed companies. The emerging companies are applying genetic engineering to exploit complementarities and substitutabilities between seed and other crop inputs. This article develops a model of competing technologies where one substitutes for a conventional input. A monopolist may cross-subsidize a technology that substitutes for an input in order to price discriminate between user types. In duopoly, a socially excessive or insufficient share of acres may be subject to an input substituting technology. Welfare improving regulations are identified in the case where a technology substitutes for an externality generating input.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":154916487,"openaccessinfo":{"externalids":{"MAG":"2070735356","ACL":null,"DOI":"10.1111\/1467-8276.00311","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The objective of this work was to investigate the variation of lipid content in beans from different varieties of Coffea canephora Pierre specie, from the Coffee Germplasm Bank, of Instituto Agronomico, Campinas, SP, Brazil. Samples of green coffee from 47\u00a0plants were analysed: Robusta (3), Kouilou or Conilon\u00a066 (13), Apoata (12), Guarini (8), Laurentii (7) and Bukobensis (4). Oil content was determined after a petroleum ether extraction. Results showed difference among the average lipid content in Kouilou, at 7.33% and Robusta, at 10.91%. Differences were also observed within plants from the six varieties ranging from 15.57% to 21.63%, for Apoata and Laurentii, respectively.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":85160032,"openaccessinfo":{"externalids":{"MAG":"2072798452","ACL":null,"DOI":"10.1590\/S0100-204X2005001200015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo examine whether transrectal voiding ultrasonography (TRVUS) can evaluate voiding movement in men with dysfunctional voiding.\n\n\nMETHODS\nNinety-nine consecutive men complaining of voiding difficulties without benign prostatic hyperplasia, prostatic cancer, severe bladder neck contracture and urethral stricture received uroflowmetry and TRVUS. Those who had abnormal findings on both uroflowmetry and TRVUS underwent subsequent cystometry combined with electromyography (EMG) to confirm the presence of dysfunctional voiding.\n\n\nRESULTS\nUroflowmetry indicated abnormal findings in 31 of the 99 patients, and TRVUS demonstrated abnormal movements of the posterior urethra during voiding in all of these 31 patients and 11 of the other 68 patients whose uroflowmetry did not indicate abnormality. TRVUS findings of the former 31 were divided into type E (the external urethral sphincter closed or intermittently opened while the bladder neck manifested an opening movement of > 7 mm during voiding in 20) and type I (both the bladder neck and external urethral sphincter manifested an intermittent movement of < 7 mm in 11). Subsequent cystometry combined with EMG in the 31 patients who had abnormal findings on both uroflowmetry and TRVUS revealed overactivity of the external urethral sphincter (OS) and underactivity of the detrusor (UD) in 85 and 35% of type-E group and 55 and 73% of type-I group, respectively. Type E included significantly more OS without UD than type I (65 vs. 18%; p = 0.0233). All of type-E (20\/20) and 91% of type-I (10\/11) patients had voiding difficulty which resulted from either OS or UD, while a very limited number of patients (4\/31) manifested neurological symptoms such as paraplegia except for voiding difficulties.\n\n\nCONCLUSIONS\nBoth uroflowmetry and TRVUS are easy and useful methods to evaluate dysfunctional voiding in men, especially when neural disorders or organic obstruction of the lower urinary tract are not apparent.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37583306,"openaccessinfo":{"externalids":{"MAG":"52488883","ACL":null,"DOI":"10.1159\/000480800","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider the problem of planning a path for image-based eye-in-hand visual servoing applications, when using an uncalibrated camera. Recent developments in this field lead to analytical interpolation between two views of an unknown object, in the projective space. Literature also provides extensions of these approaches that account for the target visibility constraint. Unfortunately, these extensions require an (even weakly) calibrated camera, and involve iterative algorithms that are not proven to converge. In this paper, we propose a modification of an existing projective interpolation algorithm that guarantees the visibility of the observed target, while avoiding the use of any knowledge on the camera calibration parameters, nor on the observed object","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":9196231,"openaccessinfo":{"externalids":{"MAG":"2140099586","ACL":null,"DOI":"10.1109\/TRO.2006.878955","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chemical fibers such as glass fiber and aramid cover a large proportion of sound-absorbing composite materials on the current commercial market. These materials possess superior mechanical properties but have the disadvantages of high production costs and energy consumption and difficult recovery and degradation. In this paper, jute fiber and polypropylene were selected as raw materials, and a series of jute fiber-reinforced polypropylene composite materials were prepared by a mixing-hot-pressing process. The acoustic and mechanical performances of the composites with different fiber contents and fiber residue ratios were discussed. The results showed that the sound absorption coefficient values increased with the increasing fiber content and decreasing residual gum ratio. The mechanical properties varied inversely with the residual gum rate. With the increase of fiber content, the tensile and bending strengths first increased and then decreased. Therefore, the jute fiber-reinforced polypropylene composites can possess favorable sound absorption performance with no mechanical property penalty by adjusting the parameters properly, demonstrating that the composite materials have promising applications in the acoustic field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244105779,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acsomega.1c04605","PubMedCentral":"8613868","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.1c04605","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper introduced an automatic generation method of falling motions for humanoid robots to minimize a damage. The proposed approach used a PGA based optimization technique to find a set of joint trajectories which minimize a damage of the falling over and down. Injection-migration PGA technique is introduced and compared with EMO and various migration topologies. To verify the proposed method, experiments for falling motions were executed for Sony QRIO robot in Webots simulation environments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":106969814,"openaccessinfo":{"externalids":{"MAG":"815011690","ACL":null,"DOI":"10.5302\/J.ICROS.2009.15.3.280","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This is the season to reconsider your faith. Do you believe? Or do you consider that everything you once believed in is without foundation? In that case, how strong was your faith in the first place? Did you believe because that is what you were taught to do? This would be true for many of us who read medical journals. But is your dogma prepared to learn new tricks? It should be\u2014at least, that is the conclusion of Faina Linkov, Mita Lovalekar and Ronald LaPorte, who have decided to ruin the festive season by shattering our faith in peer review\u2014and more importantly, in scientific journals generally (pp. 596-598). \n \nThey expose us to something that Al Gore, the man who could have been president had it not been for a quirk of arithmetic, would have approved of. They expose us to an inconvenient truth, a phrase that Gore coined with his lectures, film and campaign about climate change. And in the true spirit of any self-respecting publication, which is fully prepared to accept a great idea when hit in the face, the JRSM is borrowing that idea and adapting it. \n \nThis issue features a special section that explores the inconvenient truths in the world of medicine and health care, with particular focus on the UK. The brief for our writers was to choose a topic that they believe to be an elephant in our consulting rooms, on ward rounds or in the arena of health policy\u2014something so big, bothersome and probably pungent that nobody dares talk about it. \n \nThe choices of our correspondents are revealing. Ian Forgacs kicks off with a sorry tale of how he shed his principles and seat at the high table of The Medical Committee Against Private Practice to pocket the private shilling (p. 645). Aneez Esmail considers the patient consultation and offers the sensible verdict that our service to patients would improve if general practitioners offered a minimum fifteen minutes for each consultation; something both blindingly obvious and blindingly difficult to implement, although inconvenient truths are not necessarily pragmatic (pp. 645-646). \n \nDaniel Sokol\u2014who elsewhere reviews the ethically dubious but fascinating history of doctors deceiving patients (pp. 633-637)\u2014and Samantha Hettige choose to reprimand clinicians for their love of illegible handwriting, a situation that takes some explanation in a world (rightly) obsessed with patient safety (p. 646). But as somebody with notoriously illegible handwriting, I suggest that the electronic world beloved of Linkov and colleagues might be the answer to the prayers of all practitioners of illegibility. \n \nHasantha Gunasekera tackles the tricky issue of terrorism and our obsessive fear of air travel when we are at greater risk while driving to an airport to catch a flight (p. 647). As he puts it, 'Where are the masses sweating and shaking with fear as they climb into their cars?' While terrorism is a global problem that has to be addressed, Gunasekera reminds us of the words of American public health expert Jeffrey Sachs: 'We need to keep September 11 in perspective, especially because the ten thousand daily deaths (from AIDS, TB, and malaria) are preventable.' \n \nInterestingly, two of our writers focus on a similar theme. Sophie Petit-Zeman and Phil Hadridge identify the lack of compassion demonstrated by the National Health Service as a fundamental failure of medical care (pp. 647-648). We all know that their lament is plausible, but how many of us have ever done anything about it? John Main wraps up this special section and issue with an inconvenient truth for doctors: we have great jobs, we are paid well, and this is as good as it gets, so we should all stop whinging (p. 649). \n \nAnd what of Linkov, Lovalekar and LaPorte? Their article does not appear in the inconvenient truths section, but it is an inconvenient truth for readers, authors, peer reviewers, publishers and even journal editors: the scientific journal process is not a part of the scientific method, journals are not 'fit for purpose', and science deserves a better method of disseminating information, a method that is free of faith but full of rigour. That's one inconvenient truth that I could not possibly agree with\u2014or could I? This issue contains much else to enjoy, debate and disagree with, and as long as journals retain or acquire faith in that formula they will continue to serve scientists and clinicians.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":62273757,"openaccessinfo":{"externalids":{"MAG":"2052458854","ACL":null,"DOI":"10.1258\/jrsm.99.12.595","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1676331?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In this study, we are aimed to prevent grain growth of semi-solid AZ31 magnesium alloys during reheating process. The semisolid AZ31+(Ca) billets were investigated by using metallographic analysis, X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy in order to elucidate the effect of Ca addition during reheating process. The grain growth of semisolid AZ31+(Ca) billet was reduced with increasing Ca content during reheating. The grain size of AZ31+(Ca) billet decreased with increasing volume fraction of Al2Ca particles. The grain growth rate constant K calculated by Oswald ripening LSW theory in AZ31+1.5wt.% Ca billet was the lowest 129.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":199913306,"openaccessinfo":{"externalids":{"MAG":"2963592458","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The following study describes the development of two immunoassays for the semiquantitative determination of the organophosphorus compound methyl phosphonic acid, p-aminophenyl 1,2,2-trimethyl-propyl diester (MATP). These assays are a direct competitive, labelled-hapten, enzyme immunoassay and a competitive enzyme immunoassay with indirectly labelled antibody, both with luminescence determination of peroxidase. A camera luminometer was used to determine final signal strength. A constant light reaction was reached using luminol (5-amino-2,3-dihydro-1,4-phalazinedione), and by adding coumaric acid as an enhancer. A five minute interval was selected as exposure time. This phototechnical system makes a semiquantitative detection of MATP possible. The detection limits for both assays were at 10(-6)mol\/l MATP. With the help of a microtiter luminometer (reader) the detection limit was reduced to 5 x 10(-8) mol\/l MATP, by measuring the real intensity of the chemiluminescence signal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23170996,"openaccessinfo":{"externalids":{"MAG":"2073471690","ACL":null,"DOI":"10.1080\/15321819208021231","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Multivariate Time Series (MTS) forecasting involves modeling temporal dependencies within historical records. Transformers have demonstrated remarkable performance in MTS forecasting due to their capability to capture long-term dependencies. However, prior work has been confined to modeling temporal dependencies at either a fixed scale or multiple scales that exponentially increase (most with base 2). This limitation hinders their effectiveness in capturing diverse seasonalities, such as hourly and daily patterns. In this paper, we introduce a dimension invariant embedding technique that captures short-term temporal dependencies and projects MTS data into a higher-dimensional space, while preserving the dimensions of time steps and variables in MTS data. Furthermore, we present a novel Multi-scale Transformer Pyramid Network (MTPNet), specifically designed to effectively capture temporal dependencies at multiple unconstrained scales. The predictions are inferred from multi-scale latent representations obtained from transformers at various scales. Extensive experiments on nine benchmark datasets demonstrate that the proposed MTPNet outperforms recent state-of-the-art methods.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":261076492,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2308.11946","PubMedCentral":null,"ArXiv":"2308.11946"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Extracting and processing information from Web pages is an important task in many areas like constructing search engines, information retrieval, and data mining from the Web. A common approach in the extraction process is to represent a page as a \"bag of words\" and then to perform additional processing on such a flat representation. We propose a new, hierarchical representation that includes browser screen coordinates for every HTML object in a page. Using visual information one is able to define heuristics for the recognition of common page areas such as header, left and right menu, footer and center of a page. We show in initial experiments that using our heuristics defined objects are recognized properly in 73% of cases. Finally, we show that a Naive Bayes classifier, taking into account the proposed representation, clearly outperforms the same classifier using only information about the content of documents.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":273998,"openaccessinfo":{"externalids":{"MAG":"2121871415","ACL":null,"DOI":"10.1109\/ICDM.2002.1183910","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives: Biomarker research in Parkinsons lacks a systematic bibliometric review, despite a growing body of bibliometric studies. This study aimed to analyze publications on biomarkers that may play an important role in the diagnosis and treatment of Parkinsons disease.\nMaterials and Methods: In the study, bibliometric methods were used to analyze the related research in depth. Data were obtained from the Web of Science Core Collection database. Specific keywords consisting of MeSH terms were used as search criteria. The search was conducted in English and the type of publication was selected as article. Microsoft Excel, VOS viewer and the visualization and analytical capabilities of the Biblioshiny R package were used in the analysis, providing a versatile approach to achieve the study objectives.\nResults: A total of 461 articles on Parkinsons disease biomarkers published between 2002 and 2023 in 170 journals met the criteria and were analyzed. Regarding publications and citations, the year 2022 stood out. Each document had an average of 6.28 co-authors. The main contributing countries were the United States, China and Italy, with a global co-authorship rate of 30.8%. Notable institutions included the University of Washington, Ruhr University Bochum and the Paracelsus Elena Clinic. \"Journal of Neurochemistry,\" was the journal with the most publications. Through their total link strength, prominent terms such as \"Parkinsons disease\", \"biomarker\" and \"alpha-synuclein\" showed significant occurrences and thematic relevance.\nConclusion: The present study presents the inaugural bibliometric evaluation of biomarkers in Parkinsons disease. The gradual increase of papers since 2012 indicates persistent scholarly interest and foretells continued significance over the following ten years. Future research will be aided by the study's depiction of biomarker patterns, which provides insightful information. The term \"Alpha-synuclein\" stood out, highlighting its relevance in our research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":264502031,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5455\/annalsmedres.2023.09.253","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"E-portfolios are student-centred, potentially transformative and disruptive and also can be used for very different purposes within the same institution. It is important to note that e-portfolio Introduction usually requires some changes to approaches to teaching and learning and that the major benefits are for the learners who may be resistant to their use initially as this student-centred approach to learning can be seen as more effortful for them. (JISC 2008) A major strength of e-portfolios is that they can be used for a range of purposes, including formative feedback and summative assessment, application for employment, professional accreditation, transition between institutions and\/or employment, and for less high-stakes purposes such as supporting and recording personal growth and learning (Thanet College, 2011). One of the main elements of DCU's strategy is to provide an ePortfolio for all of our students for life. The main aims of the DCU e-portfolio are: 1) To provide students with an online portfolio, which will help them showcase their work and experiences (curricular and extra-curricular) throughout their academic careers at DCU, and accessible by them\/taken with them following graduation. 2)To provide students with an online repository, for storing relevant materials (documents, weblinks to videoclips etc, powerpoint presentations) which demonstrates the development of the student's Graduate Attributes+ To meet this strategic objective we needed to decide do we buy an ePortfolio system off the shelf or do we build one ourselves. This paper outlines our journey so far in providing an ePortfolio system for students and explains our reasoning for those institutions that face similar decisions","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":117350342,"openaccessinfo":{"externalids":{"MAG":"2751985753","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 58-yr-old woman developed an extreme acute hypernatremia (serum sodium level 200 mmol\/l) with generalized seizures and coma after a laparoscopic intervention for a liver hydatid cyst excision complicated by cyst rupture and followed by a peritoneal sterilization of the cyst content with 30% hypertonic saline solution. Hemodialysis was started with correction of hypernatremia at a speed of 1 meq\/l\/h. Brain magnetic resonance imaging scan, performed within 24 h, is shown in the figure. Fluid attenuated inversion recovery images of the patient (panel A) are compared with those obtained from a normal subject at the same slice level for comparison (panel B). Diffusion weighted images of the patient (panel C) are also compared with those of a normal subject (panel D). Images in panels A and C showed juxtacortical edema in most regions of the limbic system network, namely the amygdala and hippocampus (short black arrows), mamillary body (white arrows), temporalpole,orbitofrontal cortex, insula (shortwhitearrows), anterior cingulum (black arrowhead), and fornix (white arrowhead). The lesions appear hyperintense in diffusion weighted imaging, consistent with prominent cytotoxic edema. Ten days later, a repeated neuroimaging study showed signs of symmetrical coagulative necrosis in the amygdala, hippocampus, and hypothalamus. The patient's state of consciousness partially improved, with neurologic sequelae of amnesia and aphasia. Severe hypernatremia may produce central pontine or extrapontine myelinolysis and neuronal damage, depending on the level and duration of hypernatremia and the rapidity of its onset. Neuroimaging findings presented here demonstrate a selective vulnerability of the regions belonging to the limbic system network to the effects of an acute and extreme hypernatremia. This condition might be sustained by a predisposing condition of the limbic system towards glutamate excitotoxicity, as suggested by observational studies.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":34764489,"openaccessinfo":{"externalids":{"MAG":"2051955017","ACL":null,"DOI":"10.1097\/ALN.0b013e3181eff51a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nMucosal healing is the endoscopic treatment target in inflammatory bowel disease. The treat-to-target strategy, emphasizing proactive assessment and optimizing treatment, is commonly applied in the clinical setting. Although colonoscopies are essential for this strategy to be successful, bowel preparation and sedative drugs are required for paediatric patients. We attempted to verify the usefulness of sigmoidoscopy, which is less invasive than colonoscopy, combined with faecal calprotectin, to assess mucosal healing.\n\n\nMETHODS\nA total of 58 paediatric patients diagnosed with ulcerative colitis and followed up at Severance Children's Hospital from March 2015 to May 2018 were enrolled. Clinical data and laboratory findings (including faecal calprotectin and endoscopic data) were collected from medical records. The predictive power of mucosal healing of sigmoid colon and rectum (s-MH) combined with faecal calprotectin to predict mucosal healing throughout the colon was analysed.\n\n\nRESULTS\nAmong 58 patients (mean age 16.13 \u00b1 2.88 years), 18 (31.0%) were in mucosal healing status. The median faecal calprotectin level was 486.5 \u03bcg\/g. The faecal calprotectin cutoff value for predicting mucosal healing, identified using receiver-operating characteristic analyses, was 148 \u03bcg\/g (area under the curve, 0.81). Sensitivity, specificity, positive predictive value, and negative predictive value of s-MH in predicting mucosal healing were 1.0, 0.82, 0.72, and 1.0, respectively. When we combined s-MH with faecal calprotectin less than the cutoff value, the sensitivity, specificity, positive predictive value, and negative predictive value were 0.56, 1.0, 1.0, and 0.83, respectively.\n\n\nCONCLUSION\nFor patients with a low faecal calprotectin level, sigmoidoscopy might be sufficient to assess mucosal healing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204924082,"openaccessinfo":{"externalids":{"MAG":"2982164479","ACL":null,"DOI":"10.1097\/MEG.0000000000001550","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The exploration of electronic media, among other things, as a veritable tool through which the pristine messages of Islam are conveyed has not gone unrecognisedby contemporary scholars in Nigeria. However, the manner and style adopted by advocates on propagating slam differ and with this difference, the result of the act also differs This work comparatively studied two radio dacwah programmes in Ilorin; Madrasatud-dal\u012blish-shariciy and Manhajahlus Sunnahwaljamaca, with a view to identifying the impact of each of the two programmes on the masses. Giving the structural survey of selected episodes, the study is descriptive, and comparative in focus; therefore, the researchers adopted a combination of descriptive the comparative research methods. Findings of the work revealed that Manhajahlus Sunnahwaljamaca is largely satirical while Manhajdalilish-Sharica is academic. It is,however, recommended that the focus and locus of any dacwah activity should principally be both mild and academic. This, as a matter of fact, could be actualized by creating an institution that regulates dacwah conducts in every society.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":249937298,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.47963\/ojorhv.v6i2.869","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journal.ucc.edu.gh\/index.php\/ojorhv\/article\/download\/869\/446","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The Morph system provides a framework for automatic collection and management of profile information and application of profile-driven optimizations. In this paper, we focus on the operating system support that is required to collect and manage profile information on an end-user's workstation in an automatic, continuous, and transparent manner. Our implementation for a Digital Alpha machine running Digital UNIX 4.0 achieves run-time overheads of less than 0.3% during profile collection. Through the application of three code layout optimizations, we further show that Morph can use statistical profiles to improve application performance. With appropriate system support, automatic profiling and optimization is both possible and effective.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-48":1,"2014-10":1}},"corpusid":1067037,"openaccessinfo":{"externalids":{"MAG":"2153228154","ACL":null,"DOI":"10.1145\/268998.266640","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Code summaries are short natural language (NL) descriptions of code snippets that help developers better understand and maintain source code. Due to the pivotal role of code summaries in software development and maintenance, there is a surge of works on automatic code summarization to reduce the heavy burdens of developers. However, contemporary approaches only leverage the information within the boundary of the method being summarized (i.e., local context), and ignore that using broader context could assist with code summarization. In this paper, we explore two global context information, namely intra-class and inter-class context information, and propose the model CoCoGUM: Contextual Code Summarization with Multi-Relational Graph Neural Networks on UMLs. CoCoGUM first incorporates class names as the intra-class context, which is further fed to a Transformer-based sentence embedding model to extract the class lexical embeddings. Then, relevant Unified Modeling Language (UML) class diagrams are extracted as inter-class context and we use a Multi-Relational Graph Neural Network (MR-GNN) to encode the class relational embeddings. Class lexical embeddings and class relational embeddings, together with the outputs from code token encoder and AST encoder, are passed to the decoder armed with a two-level attention mechanism to generate high-quality context-aware code summaries. We conduct extensive experiments to evaluate our approach and compare it with other automatic code summarization models. The experimental results show that CoCoGUM outperforms state-of-the-art methods.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":225879228,"openaccessinfo":{"externalids":{"MAG":"3036257804","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. Two mitochondrial forms of acetoacetyl-CoA thiolases designated as enzyme A and enzyme B were crystallized from ox liver. They could be shown to be homogenous by polyacrylamide gel electrophoresis. 2. In direction of acetoacetyl-CoA cleavage enzyme A shows a double competitive substrate inhibition when acetoacetyl-CoA is varied at different fixed CoA concentrations. With enzyme B a parallel kinetic pattern is obtained when acetoacetyl-CoA is varied at different fixed CoA concentrations. In direction of acetoacetyl-CoA synthesis both enzymes show linear reciprocal plots of initial velocities against acetyl-CoA concentrations in absence of CoA. These initial velocity kinetics in the forward and in the reverse direction are in accordance with a ping-pong mechanism of reaction for both enzymes involving an acetyl-S-enzyme as intermediate. 3. Under saturating concentrations of substrate, the ratios of acetoacetyl-CoA synthesis\/aceto-acetyl-CoA cleavage is 0.31 for enzyme A and 0.08 for enzyme B. The maximum velocity in direction of acetoacetyl-CoA synthesis of enzymes A and B are 0.43 mumol X min-1 X unit thiolase-1 and 0.10 mumol X min-1 X unit thiolase-1, respectively. 4. Both enzymes show nearly the same affinity for acetyl-CoA. The Km values are 91 muM (enzyme A) and 80 muM (enzyme B). 5. Coenzyme A and acetoacetyl-CoA both act as inhibitors in direction of acetoacetyl-CoA synthesis: coenzyme A is a nonlinear competitive inhibitor of both enzymes. Acetoacetyl-CoA exerts a negative cooperativity on enzyme A (nH = 0.63) and is a competitive inhibitor for enzyme B (Ki = 1.6 muM). 6. The catalytic and regulatory properties of the acetoacetyl-CoA thiolases A and B are discussed in terms of their proposed role in regulating ketogenesis. Intracellular fluctuations of acetoacetyl-CoA\/3-hydroxybutyryl-CoA ratios, resulting in a suspension of inhibition of both enzymes at high NADH\/NAD ratios, are postulated as a control mechanism of ketogenesis in addition to mechanisms already known.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21362207,"openaccessinfo":{"externalids":{"MAG":"1495497568","ACL":null,"DOI":"10.1111\/J.1432-1033.1975.TB02476.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Instructors of econometrics courses sometimes seek an empirical simultaneous equations application that, ideally, (i) goes beyond the two-equation case most often used in textbook examples, (ii) is based on available real-world data that can be used in hands-on exercises, (iii) replicates prominent published results, (iv) can be motivated as being of some historical importance, (v) uses accessible economic theory, and (vi) yields plausible empirical results understandable to students. The seminal but now-forgotten 1955 watermelon study of Daniel Suits is suggested as an empirical application that meets all these criteria.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":214177714,"openaccessinfo":{"externalids":{"MAG":"2998764717","ACL":null,"DOI":"10.58311\/jeconteach\/e850df12eb3d3e2dde8794bdce1d1331d9f2c491","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/downloads.journalofeconomicsteaching.org\/4\/2\/2-4.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Measurement of the energy distribution of photo protons produced in deuterium loaded nuclear emulsions was used to determine the spectral distribution of a high energy X-ray beam. Details of the method are given and experimental results are compared with theory. The results of ionization chamber measurements of the angular distribution of X-rays from various targets are given and discussed. A rough calculation of the fast neutron dose relative to the dose from the X-ray beam is given using data obtained from the nuclear plates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36867156,"openaccessinfo":{"externalids":{"MAG":"2072526207","ACL":null,"DOI":"10.1088\/0031-9155\/4\/4\/309","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Occult hepatitis B is defined as presence of HBV DNA in tissue or serum without hepatitis B surface antigen. The aim of this study is to determine frequency of occult hepatitis B among hepatitis C patients in Tehran and compare the route of transmission and liver enzymes between positive and negative HBV DNA patients. METHODS: In a cross sectional study, serum of 103 hepatitis C cases (79.6% men and 20.4% women) were analyzed for s, x and core genes via a nested polymerase chain reaction technique. RESULTS: HBV DNA was detectable in serum of 20 patients (19.4%). No significant difference in age, sex and route of transmission were seen in HBV DNA positive and negative patients. In HBV DNA positive and negative groups, mean of AST was 73, 47 (p < 0.05) and mean of ALT was 76 and 36 respectively (p < 0.05). CONCLUSION: Occult hepatitis B was observed in a considerable number of hepatitis C patients in Tehran. It was associated with elevation in liver enzyme but was not related to route of transmission.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":32611696,"openaccessinfo":{"externalids":{"MAG":"2146930525","ACL":null,"DOI":null,"PubMedCentral":"3129064","ArXiv":null},"license":"CCBYNCSA","url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We studied the airways response to inhaled isoproterenol in 182 healthy Caucasian children (98 girls and 84 boys). Significant (p < 0.003) mean percentage changes were observed for FEF75 (16 \u00b1 2.8%), FEF25\u221275 (9 + 1.6%), FEF50 (5 \u00b1 1.4%), FEV1 (1.3 \u00b1 0.4%), and FRC (1.5 \u00b1 0.5%).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29427408,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1164\/arrd.1983.128.1.210b","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: To investigate the changes of myocardial contractile function during myocardial stunning in calcium overload rats and the protective effects of tetrandrine. Methods: Forty six rats were randomized into control, myocardial ischemia, myocardial stunning, low and high dose of tetrandrine groups. Another 10 rats were used to identify the calcium overload. vitamin D 3 (0.3 million Unit\/kg) and nicotinic acid were administered. After 16 d when calcium overload occured, left anterior descending artery was ligated. Twenty minutes of myocardial ischemia followed by 60 min of reperfusion was induced. The contractile function parameters were determined dynamically. At the end of experiment, myocardial cytosolic [Ca 2+ ]i was determined in various groups. In tetrandrine groups, tetrandrine (62.2 or 93.6 \u03bcmol\/kg ) was administered by gastrogavage daily.After 16 d, the rats undergone the experiments mentioned above. Results: Sixteen days after vitamin D 3, nicotinic acid were given, [Ca 2+ ]i increased by 2.6 folds (146.8\u00b110.8) vs (368.5\u00b122.6) nmol\/L, ( P 0.01). Whereas, [Ca 2+ ]i in tetrandrine groups were (210.8\u00b116.4) and (198.6\u00b115.3) nmol\/L, which were significantly lower than that of calcium overload group. Twenty minutes of myocardial ischemia resulted in the decrease of dp\/dtmax and Vmax in all groups with the most significant in stunning and calcium overload groups. The contractile function restored gradually after reperfusion. At all time points, dp\/dtmax and Vmax in both tetrandrine groups were higher than those in both stunning and calcium overload groups. And effect with higher dose of tetrandrine were more significant than in low dose of tetrandrine. After 60 min of reperfusion, dp\/dtmax in stunning, calcium overload, low and high dose of tetrandrine groups were 49.7%, 51.5%, 71.0% and 83.4% of that in control, respectively, and Vmax were 55.0%, 49.8%, 73.9% and 77.5% of that in control, respectively. Conclusion: The myocardial contractile function in vitamin D 3 induced calcium overload group is impaired. On basis of myocardiocyte calcium overload, transient ischemia leads to myocardial stunning. At the stage of ischemia, the impaired degree of myocardial contractile function is similar to that in stunning group, suggesting at this stage the effect of ischemia on myocardial function is greater than that of calcium overload. Tetrandrine chronically improves the myocardial function in Vitamin D 3 induced calcium overload rats. [","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":75247923,"openaccessinfo":{"externalids":{"MAG":"2379083655","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The article discusses the need for the formation of the intellectual potential of international students at the preparatory faculties of Russian universities. The ways of development of cognitive abilities of students are presented with an example of chemistry subject of the Faculty of the Russian language and basic disciplines of the Russian peoples' friendship university.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":148841143,"openaccessinfo":{"externalids":{"MAG":"2711725065","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We studied the population structure of South Korea by using the distributions of surnames for all 246 administrative regions. Every 4,177 surnames are distinguished by their bon-gwan which indicates the place of their family clans. Using Fisher's Alpha, we found that the level of inbreeding increases as the distance from the capital Seoul increases. We introduced the Shannon index to measure the level of spatial diffusion for each surname population, and the geographical clusters based on similarities of the surname compositions among the regions show almost exact agreement with those at the administrative districts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256328271,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3938\/jkps.67.1698","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the era of data deluge, Big Data gradually offers numerous opportunities, but also poses significant challenges to conventional data processing and analysis methods. MapReduce has become a prominent parallel and distributed programming model for efficiently handling such massive datasets. One of the most elementary and extensive operations in MapReduce is the join operation. These joins have become ever more complex and expensive in the context of skewed data, in which some common join keys appear with a greater frequency than others. Some of the reduction tasks processing these join keys will finish later than others; thus, the benefits of parallel computation become meaningless. Some studies on the problem of skew joins have been conducted, but an adequate and systematic comparison in the Spark environment has not been presented. They have only provided experimental tests, so there is still a shortage of representations of mathematical models on which skew-join algorithms can be compared. This study is, therefore, designed to provide the theoretical and practical basics for evaluating skew-join strategies for large-scale datasets with MapReduce and Spark\u2014both analytically with cost models and practically with experiments. The objectives of the study are, first, to present the implementation of prominent skew-join algorithms in Spark, second, to evaluate the algorithms by using cost models and experiments, and third, to show the advantages and disadvantages of each one and to recommend strategies for the better use of skew joins in Spark.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":250162123,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/app12136554","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2076-3417\/12\/13\/6554\/pdf?version=1657184030","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In contrast to earlier views that argued for a particular kind of concept (e.g. prototypes), several recent accounts have proposed that there are multiple distinct kinds of concepts, or that there is a plurality of concepts for each category. In this paper, I argue for a novel account of concepts as pluralistic hybrids. According to this view, concepts are pluralistic because there are several concepts for the same category whose use is heavily determined by context. In addition, concepts are hybrids because they typically link together several different kinds of information that are used in the same cognitive processes. This alternative view accounts for the available empirical data, allows for greater cognitive flexibility than Machery's recent account, and overcomes several objections to traditional hybrid views.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":170637949,"openaccessinfo":{"externalids":{"MAG":"2028292938","ACL":null,"DOI":"10.1111\/PHPR.12128","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes a World Wide Web strategic planning process at the East Tennessee State University (ETSU) College of Medicine (COM). The process began when a Web Strategic Planning Committee was charged by the Associate Dean of Academic Affairs to craft a comprehensive plan for development of the COM Web site, because the existing Web site did not serve the needs of students, faculty, staff, or the community. Elements of existing internal documents served as the foundation for developing the strategic plan. The resulting framework outlined guiding principles, current conditions, planning assumptions, and strategies. Strategies were aligned with the COM mission and goals. Recommendations and a framework for implementation were delineated. The resulting living document serves as a guide to help align the COM mission, goals, and values with the information technology infrastructure. It soon became evident that the original charge had broader implications affecting areas such as leadership, instruction, resources, training and support, content, quality control, and technology integration. Because these are common concerns in academia, this strategic planning process may serve as a framework for other institutions. (Contains 14 references.) (Author\/MES) Reproductions supplied by EDRS are the best that can be made from the-original document.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55231577,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A game simulating practical economic decision-making has been devised and integrated into a Rowan University course on engineering economics. This paper describes the game itself, as well as a software package currently under development that will manage the game. The game challenges students to not only learn engineering economic principles such as present worth, but also to use them to make realistic economic decisions in a competitive setting. Each student starts with $10,000, and is presented with a list of investment opportunities. Students apply the principles learned in class to the possible investments and make decisions, such as how much to bid on a particular item in an auction. Additional investment opportunities are introduced weekly throughout the semester. The required analysis grows in complexity as the students' knowledge base increases. The game is interactive; for example the owner of a factory must negotiate the price of raw materials he\/she needs with the owner of a mine. The actual software is currently being developed through an NSF-CCLI sponsored project. The software will be web based, and will be a combination of standard HTML and Active Server Pages with a Microsoft Access Database. The program is designed to include an easily navigable interface for the student, and web based methods for the instructor to make changes to the overall game as necessary.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":109987053,"openaccessinfo":{"externalids":{"MAG":"2183669437","ACL":null,"DOI":"10.18260\/1-2--12528","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.18260\/1-2--12528","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The ultrafast emission dynamics of a 1.3-\/spl mu\/m (GaIn)(NAs)\/GaAs vertical-cavity surface-emitting laser is studied by femtosecond luminescence upconversion. We obtain a minimum peak delay of 15.5 ps and a minimum pulse width of 10.5 ps. Laser operation with picosecond emission dynamics is demonstrated over a temperature range from 30 to 388 K. The bandgap shift with temperature of (GaIn)(NAs)\/GaAs is determined to be about -2.9\/spl middot\/10\/sup -4\/ eV\/K, which is smaller than for GaAs. Our measurements of the optical gain provide gain spectra similar to those of commercial (GaIn)(PAs)\/InP-structures at moderate densities but broaden considerably for elevated carrier densities due to the stronger carrier confinement. We compare our experimental results with gain spectra calculated from a microscopic model and confirm the predictive capability of the model. The theoretical gain spectra are used as the input for a calculation of the temperature dependence of the (GaIn)(NAs)\/GaAs surface-emitter emission which results in very good agreement with experiment.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":120140247,"openaccessinfo":{"externalids":{"MAG":"1973702620","ACL":null,"DOI":"10.1109\/3.980275","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Surface micromachined pressure sensors with step-type bent and nearly flat membranes are compared. The influence of the membrane structure on the sensor characteristics is investigated. The sensors contain four polysilicon piezoresistors arranged at the underside of a polysilicon membrane. For the step-type bent version of the sensor polysilicon is used as sacrificial layer and aqueous TMAH solution for underetching. Devices with a nearly flat structure are fabricated by applying a combined TMAH and HF sacrificial layer etching technique of a polysilicon\/oxide sandwich. Compared to step-type bent, nearly flat structures provide decisive advantages for fabrication and show improved performance. Pressure response, noise behavior as well as the thermal drift of both types of sensors is presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":110364146,"openaccessinfo":{"externalids":{"MAG":"2101680126","ACL":null,"DOI":"10.1109\/16.535348","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The Cri du Chat syndrome (CdC) is a rare genetic disorder caused by variable size deletions of the short arm of chromosome 5 (5p\u2212). It is well known that home-reared patients show better performances as compared to institutionalised cases, and it was reported that continuous educational intervention can ameliorate their performances. To assess the efficacy of educational intervention and to develop new CdC oriented programs of rehabilitation, we compare the results obtained for many developmental skills in two groups of CdC patients undergoing two different rehabilitation programs. Using data on the development of a group of CdC patients obtained by validated Italian translation for the Denver Developmental Screening Test II, we compared a group of 13 patients undergoing an educational program developed for CdC patients, the Mayer Project (MP), with a second group of 15 cases in whom caring was not specifically oriented. A positive impact of the MP was reported by parents, observing an improvement in social skills obtained, even if no significant differences were observed when the items of the Denver Test are studied. The need for personalized care in CdC patients and the choice of different methods to compare the results are also discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58432,"openaccessinfo":{"externalids":{"MAG":"2557457035","ACL":null,"DOI":"10.1155\/2016\/3125283","PubMedCentral":"5149647","ArXiv":null},"license":"CCBY","url":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2016\/3125283.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Introduction Although chronic wounds are a major personal and economic burden, treatment options are still limited. Among those options, adipose-derived stromal cell- (ASC-) based therapies rank as a promising approach but are restricted by the harsh wound environment. Here we use a commercially available fibrin glue to provide a deliverable niche for ASCs in chronic wounds. Material and Methods To investigate the in vitro effect of fibrin glue, cultivation experiments were performed and key cytokines for regeneration were quantified. By using an established murine chronic diabetic wound-healing model, we evaluated the influence of fibrin glue spray seeding on cell survival (In Vivo Imaging System, IVIS), wound healing (wound closure kinetics), and neovascularization of healed wounds (CD31 immunohistochemistry). Results Fibrin glue seeding leads to a significantly enhanced secretion of key cytokines (SDF-1, bFGF, and MMP-2) of human ASCs in vitro. IVIS imaging showed a significantly prolonged murine ASC survival in diabetic wounds and significantly accelerated complete wound closure in the fibrin glue seeded group. CD31 immunohistochemistry revealed significantly more neovascularization in healed wounds treated with ASCs spray seeded in fibrin glue vs. ASC injected into the wound bed. Conclusion Although several vehicles have shown to successfully act as cell carrier systems in preclinical trials, regulatory issues have prohibited clinical usage for chronic wounds. By demonstrating the ability of fibrin glue to act as a carrier vehicle for ASCs, while simultaneously enhancing cellular regenerative function and viability, this study is a proponent of clinical translation for ASC-based therapies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":58034078,"openaccessinfo":{"externalids":{"MAG":"2904834747","ACL":null,"DOI":"10.1155\/2018\/1353085","PubMedCentral":"6313983","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/sci\/2018\/1353085.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Human scabies is caused by an infection of the skin by the human itch mite (Sarcoptes scabiei var. hominis). There are different medications for the treatment of scabies. This study aimed at comparing the efficacy and safety of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies. In total, 420 patients with scabies were enrolled, and randomized into two groups: the first group received a single dose of oral ivermectin 200 \u03bcg\/kg body weight, and the second group received sulfur 10% ointment and were told to apply this for three successive days. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. A single dose of ivermectin provided a cure rate of 61.9% at the 2-week follow-up, which increased to 78.5% at the 4-week follow-up after repeating the treatment. Treatment with single applications of sulfur 10% ointment was effective in 45.2% of patients at the 2-week follow-up, which increased to 59.5% at the 4-week follow-up after this treatment was repeated. A single dose of ivermectin was as effective as single applications of sulfur 10% ointment at the 2-week follow-up. After repeating the treatment, ivermectin was superior to sulfur 10% ointment at the 4-week follow up. The delay in clinical response with ivermectin suggests that it may not be effective against all the stages in the life cycle of the parasite. .","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2269793,"openaccessinfo":{"externalids":{"MAG":"1461275635","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Occurrence of Candida nivariensis and Candida bracarensis, two species phenotypically similar to Candida glabrata sensu stricto, in human clinical samples from different geographical settings remains unknown. This study developed a low-cost multiplex PCR (mPCR) and three species-specific singleplex PCR assays. Reference strains of common Candida species were used during development and the performance of mPCR and singleplex PCR assays was evaluated with 440 clinical C. glabrata sensu lato isolates. The internal transcribed spacer (ITS) region of rDNA was also sequenced from 85 selected isolates and rDNA sequence variations were used for determining genetic relatedness among the isolates by using MEGA X software. Species-specific amplicons for C. glabrata (~360 bp), C. nivariensis (~250 bp) and C. bracarensis (~180 bp) were obtained in mPCR while no amplicon was obtained from other Candida species. The three singleplex PCR assays also yielded expected results with reference strains of Candida species. The mPCR amplified ~360 bp amplicon from all 440 C. glabrata sensu lato isolates thus identifying all clinical isolates in Kuwait as C. glabrata sensu stricto. The results of mPCR were confirmed for all 440 isolates as they yielded an amplicon only in C. glabrata sensu stricto-specific singleplex PCR assay. The rDNA sequence data identified 28 ITS haplotypes among 85 isolates with 18 isolates belonging to unique haplotypes and 67 isolates belonging to 10 cluster haplotypes. In conclusion, we have developed a simple, low-cost mPCR assay for rapid differentiation of C. glabrata sensu stricto from C. nivariensis and C. bracarensis. Our data obtained from a large collection of clinical C. glabrata sensu lato isolates show that C. nivariensis and C. bracarensis are rare pathogens in Kuwait. Considerable genetic diversity among C. glabrata sensu stricto isolates was also indicated by rDNA sequence analyses.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204757258,"openaccessinfo":{"externalids":{"MAG":"2980859565","ACL":null,"DOI":"10.1371\/journal.pone.0223920","PubMedCentral":"6795469","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0223920&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract The author takes an outsider's look at sociolinguistics and aims various criticisms at it. He sees the discipline's reluctance to let go of proper sociological and historical questions while at the same time insisting on remaining strictly a branch of linguistics as its first and foremost problem from which the rest ultimately derive. More specifically, he criticizes the idealistic and ahistorical use of such terms as \"language\" and \"dialect\" and the failure to see the usefulness of \"patois\"; the failure properly to define \"bilingualism\" and \"diglossia\" and to see the fundamental distinction between them; and the unfortunate confusion created around the idea of \"code switching,\" which inextricably mixes together (i) sociologically significant language switching (typical of situations of bilingualism), (ii) cases of diglossia, (iii) the would-be monolingualism of as yet imperfectly assimilated immigrant or subject populations, and (iv) a ragbag of banal individual examples too idiosyncratic to be sociologically meaningful.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":144211681,"openaccessinfo":{"externalids":{"MAG":"2071775876","ACL":null,"DOI":"10.1515\/ijsl.2010.046","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effect of using an indium flux during the MBE growth of GaN layers was investigated. The properties of these layers were studied using electron probe microanalysis, secondary ion mass spectroscopy, photoluminescence and cathodoluminescence. The optical properties of the GaN layers are shown to improve as compared with undoped GaN layers grown under nominally the same conditions but without an additional indium flux.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250821868,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0268-1242\/13\/12\/001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Type X is one of four Post-Lapita pottery styles reported from Huon Peninsula and the Siassi Islands of Papua New Guinea. Previous petrographic work was inconclusive about its likely area of origin but indicated a possible Huon Peninsula source. Renewed analysis of a larger sample supports this conclusion and confirms the use of grog temper. This kind of temper is otherwise not recorded in the New Guinea region, and its use in the production of Type X was probably culturally driven. Comparisons between Type X and grog-tempered pottery from Palau, Yap, and Pohnpei in Micronesia lead to the suggestion that Type X probably derived from an otherwise unrecorded contact between Huon Peninsula and Palau about 1000 years ago. The article reviews other evidence for interaction between the New Guinea-Bismarck Archipelago region and various parts of Micronesia and concludes that the proposed Type X connection with Palau is but one of several prehistoric contacts between different parts of the regions. Recognition of such contacts, which could have been unintentional and on a small scale, may contribute to explaining the complex ethnolinguistic situation of Huon Peninsula.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":54918853,"openaccessinfo":{"externalids":{"MAG":"1966480600","ACL":null,"DOI":"10.1353\/ASI.2006.0015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes the effects of the growth of exports, manufactured and primary exports on the growth of GDP for Jordan between 1964 and 2004. This contribution shows that structural changes have such an impact on the sources of growth, which in turn will affect the export-growth relationship. A VAR analysis of Jordanian yearly trade and GDP growth has been used; causality tests are applied to the entire period as well as two subperiods. Statistical tests confirm export-led growth for the full period and for the first subperiod, but tests on the recent subperiod 1989-2004, show growth causing primary exports. In addition, there is a bidirectional causal relationship between primary exports and manufactured exports. Therefore, policies in Jordan should not discriminate against the export of primary products. Instead, they should conform to policies that aim at export promotion.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":154970880,"openaccessinfo":{"externalids":{"MAG":"2173559584","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The propagation characteristics of a surface acoustic wave (SAW) that travels along the surface of a solid object can vary significantly depending on the surrounding environment. SAW devices are employed in sensors that measure many different kinds of environments and their changes. This paper discusses a SAW sensor used to measure the concentration of methanol, a fuel required by methanol fuel cells. The permittivity of methanol exhibits significant variation depending on the concentration and the temperature. Two SAW resonators were used to measure the permittivity of a liquid; one with the cavity surface as an electrically open circuit, and the other short-circuited. Two resonating systems were constructed from an amplifier and a SAW resonator, and fluid was allowed to run through the cavities of the two resonators to measure the difference in the oscillation frequency. This difference in frequency changed in proportion to the permittivity of the liquid, so that its concentration could be measured. It was also experimentally demonstrated that the use of SAW resonators can stabilize measurements and improve reproducibility. A sensing system made of liquid flow cells and SAW sensors was then proposed. The proposed system is able to measure the real time concentration of methanol independently of the temperature and with good reproducibility.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":12666736,"openaccessinfo":{"externalids":{"MAG":"2109770763","ACL":null,"DOI":"10.1109\/FREQ.2008.4623054","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Local farmers in South Kalimantan (Banjarese farmers) use to grow local rice cultivars. The local rice growing areas are varied with distance from the coastal line. Consequently, the degree of salinity also varied. To overcome the salinity problem, farmers do their last transplanting earlier than the farmers in the inland area and grow the local rice cultivars that they believe tolerant to salinity. In this study, we investigate the local rice cultivars grown by the farmers in the coastal areas. Sixty paddocks were selected in Pulantan, Aluh-Aluh, Simpang Warga and Bunipah Villages, Aluh-Aluh District, Banjar Regency, South Kalimantan. The rice yield of each paddock was estimated by sampling 3 x 5 hills in 3 replicates. The soil was collected within the 3 x 5 hills area and analysed their electric conductivity (EC) and pH. We found that there were four families of local rice cultivars grown, namely, Palas, Bayar, Pandak and Siam families. Among all local rice cultivars grown, it was revealed that Pandak Putih and Siam Unus produced the highest yields. However, according to the farmers, Palas and Bayar families are the common rice tolerant to salinity. The good price of Siam family and good yield of Pandak family at other paddocks might become the considerant of growing such rice families in the study site.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":134828814,"openaccessinfo":{"externalids":{"MAG":"2909862267","ACL":null,"DOI":"10.5400\/JTS.2008.V13I2.103-109","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One of the most desired aspects for power suppliers is the acquisition\/sell of energy in a future time. This paper presents a study of load forecasting for power suppliers, presenting a comparative application of the techniques of wavelets, time series methods and neural networks, considering short and long term forecast; both of great importance for power suppliers in order to define the future power consumption of a given region.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110145011,"openaccessinfo":{"externalids":{"MAG":"2036335960","ACL":null,"DOI":"10.1117\/12.748397","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Interstrand cross-links in cellular DNA are highly deleterious lesions that block transcription and replication. We recently characterized two new structural types of interstrand cross-links derived from the reaction of abasic (Ap) sites with either guanine or adenine residues in duplex DNA. Interestingly, these Ap-derived cross-links are forged by chemically reversible processes, in which the two strands of the duplex are joined by hemiaminal, imine, or aminoglycoside linkages. Therefore, understanding the stability of Ap-derived cross-links may be critical in defining the potential biological consequences of these lesions. Here we employed bacteriophage \u03c629 DNA polymerase, which can couple DNA synthesis and strand displacement, as a model system to examine whether dA-Ap cross-links can withstand DNA-processing enzymes. We first demonstrated that a chemically stable interstrand cross-link generated by hydride reduction of the dG-Ap cross-link completely blocked primer extension by \u03c629 DNA polymerase at the last unmodified nucleobase preceding cross-link. We then showed that the nominally reversible dA-Ap cross-link behaved, for all practical purposes, like an irreversible, covalent DNA-DNA cross-link. The dA-Ap cross-link completely blocked progress of the \u03c629 DNA polymerase at the last unmodified base before the cross-link. This suggests that Ap-derived cross-links have the power to block various DNA-processing enzymes in the cell. In addition, our results reveal \u03c629 DNA polymerase as a tool for detecting the presence and mapping the location of interstrand cross-links (and possibly other lesions) embedded within regions of duplex DNA.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":43990599,"openaccessinfo":{"externalids":{"MAG":"2461808601","ACL":null,"DOI":"10.1021\/acs.biochem.5b00482","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc4826736?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Measurements were performed on leaves of Clusia rosea Jacq. trees in the moist central mountains (330 to 365 m above sea level) and at the dry south coast of St John Island (US Virgin Islands, Lesser Antilles). Seedlings of C. rosea were also studied in the central hills. During the study period (March 1989) all trees showed crassulacean acid metabolism (CAM), in which net CO2 uptake extended for a remarkably long time in the morning (phase II of CAM: until about 11 to 12 h) and contributed about 1\/3 of total net CO2 -uptake. During the night (phase I of CAM) malic acid and citric acid were accumulated concurrently at a molar ratio of malic: citric acid of about 1.6. Internal recycling of respiratory CO2 was 20% of total CO2 fixed during the night. Water-use-efficiency (mol CO2 taken up: mol H2 O transpired) was 0.014 to 0.022. The pH of leaf-cell sap at the end of the dark period was 2.85. This would still allow an H+ -ATPase at the tonoplast to transport 2H+ into the vacuole per ATP hydrolysed when operating near thermodynamic equilibrium. Free sugars, glucose and fructose, and starch were used as precursors for the CO2 -acceptor phosphoenolpyruvate during the dark period; contributions of the two hexoses were about equal and together four-times that of starch. Xylem tensions showed increases of up to 8 bar during day-time. Leaf-sap osmotic pressures did not change significantly; the trend was a small decline during day-time. Among the seedlings, three different modes of photosynthesis were encountered, namely C3 -photosynthesis in terrestrial and in epiphytic seedlings, continuous stomatal opening and CO2 -uptake day and night in epiphytic seedlings, and CAM in seedlings growing in the tanks of Aechmea lingulata (L.) Baker.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":83559352,"openaccessinfo":{"externalids":{"MAG":"1936072105","ACL":null,"DOI":"10.1111\/J.1469-8137.1991.TB00012.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients' survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox's analyses were performed to identify the independent factors. Results The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25-6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59-6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98-41.73; p<0.001) were independent prognostic markers for poor survival rates. Conclusion In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7554095,"openaccessinfo":{"externalids":{"MAG":"2106881558","ACL":null,"DOI":"10.4046\/trd.2014.76.5.218","PubMedCentral":"4050069","ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.e-trd.org\/upload\/pdf\/trd-76-218.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper continues the analysis of political theory in the Hebrew Bible. In earlier work I argue that the Garden of Eden story explores why people have an obligation to obey the law. The narratives that follow describe a \"Dark Age\" characterized by accelerating violence and ending in a catastrophic flood. These texts expand the analysis of the Eden narratives by asking whether human beings can achieve a good and decent life in the absence of government and law. The narratives describe an experiment in which people interact strategically in an environment where cooperation can generate a surplus but defection is always possible. The message of the Dark Age texts is people cannot achieve a good and decent life in the absence of government and law. The story of Noah's Flood expands the analysis by arguing that human beings can achieve a good and decent life in the presence of government and law. The Tower of Babel story explains why, even with government and law in place, human societies do not achieve their full potential.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":142821252,"openaccessinfo":{"externalids":{"MAG":"1554211833","ACL":null,"DOI":"10.2139\/SSRN.1577725","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": A substantial political economy literature claims that an abundance of natural resource wealth\u2014 most particularly crude oil\u2014creates and perpetuates authoritarian regimes. Improvements in statistical techniques and data generation over the past decade have allowed scholars to evaluate that claim. That new literature finds that the evidence is inconsistent with law-like statements about the effect of crude oil abundance on authoritarianism. The rise and fall of the resource curse hypothesis may therefore be instructive as scholars advance and test other theories about the distribution of authoritarianism and democracy around the planet. Specifically, it suggests the importance of taking history seriously both in the testing of theories and in their development.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":261478966,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.4558080","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In order to obtain accurate frame-level target bit allocation and improve encoding quality, this paper presented an adaptive frame-level optimal scheme of bit allocation. This algorithm made full use of texture complexity between frames compensating the inadequacy of average bit allocation scheme in JVT-G012 rate control algorithm. Extensive experimental results show that the proposed algorithm under the circmstances of high-movement or scene change, can significantly enhance the quality of video encoding and achieve the goal of optimizing bit allocation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208853298,"openaccessinfo":{"externalids":{"MAG":"1024052558","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Selective dehydrogenation of formic acid (FA, HCOOH) is a promising alternative to fossil fuels, to provide a clean energy carrier for the future energy economy. The preparation of highly efficient catalysts for hydrogen release from FA at room temperature has attracted much attention but still remains a great challenge. Herein, ultrafine bimetallic PdIr nanoparticles (NPs) immobilized by amine-functionalized SBA-15 (PdIr\/SBA-15-NH2) have been successfully synthesized via a facile surface functionalization and co-reduction method. The characterized results showed that ultrafine bimetallic PdIr NPs with a small size of around 1.1 nm were highly dispersed on SBA-15-NH2. Among all the as-synthesized catalysts, the optimized Pd0.85Ir0.15\/SBA-15-NH2 nanocomposites (NCs) exhibited the highest catalytic activity and 100% H2 selectivity toward the selective dehydrogenation of FA, giving an initial turnover frequency (TOF) value as high as 3087 h\u22121 at room temperature. To the best of our knowledge, this is the first report showing that the Ir-containing heterogeneous catalyst can achieve a complete dehydrogenation of FA to H2. The excellent catalytic performance of this catalyst might be attributed to the modified electronic effects of Pd with Ir, the ultrafine size and high dispersion of PdIr NPs, and the synergetic interaction between the PdIr NPs and SBA-15-NH2. The amine functional groups of SBA-15-NH2 not only can lead to ultrafine and well-dispersed PdIr NPs and stabilize the PdIr NPs, but also can serve as Bronsted basic sites, which facilitates the O\u2013H bond dissociation of FA and forms a formate intermediate. The present PdIr\/SBA-15-NH2 NCs with efficient catalytic effects on the dehydrogenation of FA may greatly promote the practical application of the FA system on fuel cells.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":213292913,"openaccessinfo":{"externalids":{"MAG":"2990770262","ACL":null,"DOI":"10.1039\/c9qi01375j","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:Charles Reznikoff, according to established scholarship, is an exemplar of disinheritance, an ideal representative for the modernist and modern Jewish self. But Reznikoff also inherits and finds in this an alternative to both urban capitalism and market-influenced modernist publishing. Manually setting type at a printing press in his parents' basement, Reznikoff self-published many of his early books while also working in the family clothing business. Writing was a craft that continued, rather than broke from, his family trade. His production of texts, following his depiction of his parents' textile-work in the rarely examined memoir Family Chronicle, takes part in what we can term a \"fabriculture\" that resists commodity valuation in modern industry and modernist publishing. In the 1930 novel By the Waters of Manhattan, Reznikoff's protagonist uses the fabricultural lessons of material production to rescue the individuality of the self from the anonymity and interchangeability of the modern city. Reznikoff's poetry and prose weave together his parents' lives in textile with his own in text, establishing this inherited family trade as a metaphor for crafting a whole garment from the disparate elements of the modern Jewish self.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":192423483,"openaccessinfo":{"externalids":{"MAG":"2793283567","ACL":null,"DOI":"10.5325\/STUDAMERJEWILITE.37.1.0037","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Europe has a long and rich tradition as a centre of research and teaching in the arts and humanities. However, the huge digital transformation that affects the arts and humanities research landscape all over the world requires that we set up sustainable research infrastructures, new and refined techniques, state-of-the-art methods and an expanded skills base. Responding to these challenges, the Digital Research Infrastructure for Arts and Humanities (DARIAH) was launched as a pan-European network and research infrastructure. After expansion and consolidation, which involved DARIAH's inclusion in the ESFRI roadmap, DARIAH became a European Research Infrastructure Consortium (ERIC) in 2014. \n \nThe Horizon 2020 funded project DESIR (DARIAH ERIC Sustainability Refined) sets out to strengthen the sustainability of DARIAH and help establish it as a reliable long-term partner within our communities. Sustaining existing digital expertise, tools, resources in Europe in the context of DESIR involves a goal-oriented set of measures in order to first, maintain, expand and develop DARIAH in its capacities as an organisation and technical research infrastructure; secondly, to engage its members further, as well as measure and increase their trust in DARIAH; thirdly, to expand the network in order to integrate new regions and communities. \n \nThe DESIR consortium is composed of core DARIAH members, representatives from potential new DARIAH members and external technical experts. \n \nThe sustainability of a research infrastructure is the capacity to remain operative, effective and competitive over its expected lifetime. In DESIR, this definition is translated into an evolving 6-dimensional process, divided into the following challenges: \n \n\u2022Dissemination \n\u2022Growth \n\u2022Technology \n\u2022Robustness \n\u2022Trust \n\u2022Education \n \nWith our poster, we would like to show how the project helps sustaining DARIAH. \n \nWithin DESIR, dissemination is the ability to communicate DARIAH's strategy and benefits effectively within the DARIAH community and in new areas, spreading out to new communities. Through the international workshops held at Stanford University and at the Library of Congress, DARIAH has been introduced to many non-European DH scholars. These events were an important first step to foster international cooperation between US and European colleagues as well as a catalyst for ongoing collaborations in the future. A third workshop took place in Canberra at the Australian Research Data Commons in March 2019. \n \nDARIAH has currently 17 members from all over Europe. Nevertheless, efforts should be made to include as many countries as possible to bring in and scale, to a European level, even more state-of-the-art DH activities. \n \nSix candidates ready for building strong national consortia have been identified, enabling a substantial expansion of DARIAH's country coverage. Additionally, thematic workshops are organised in each country as well as tailored training measures. \n \nDESIR widens the research infrastructure in core areas which are vital for DARIAH's sustainability but are not yet covered by the existing set-up. As DARIAH expands across Europe, continuously enhancing and further developing the ERIC exceeds DARIAH's internal technological capacities. Two notable results were achieved so far: firstly, the publication of a technical reference as a result of a workshop organised in October 2017 with CESSDA and CLARIN. It's a collection of basic guidelines and references for development and maintenance of infrastructure services within DARIAH and beyond, addressing an ongoing issue for research infrastructures, namely software sustainability. Secondly, the organisation of a Code Sprint, focusing on bibliographical and citation metadata, which helped shaping DARIAH's profile in four technology areas (visualisation, text analytic services, entity-based search and scholarly content management). Another Code sprint is expected to take place in Summer 2019. \n \nAnother output is the implementation of a centralized helpdesk. This helpdesk is hosted by CLARIN-D and the solution of integration within the existing DARIAH website was the creation of a WordPress plugin. This plugin is used to connect our website with the OTRS server and allows the creation of issues easily by users unfamiliar with OTRS. \n \nSustaining a research infrastructure involves also two important aspects: trust and education. For DARIAH, it is crucial to increase trust and confidence from its users. In DESIR we develop recommendations and strategies accordingly, targeting new cross-disciplinary communities, based on the results of a survey and interviews addressed to the scientific community, with different levels of approach - national, institutional and individual. \n \nIn addition, education is a key area and the project contributes to the ongoing discussions about the role and modalities of training and education in the development, consolidation and sustainability of digital research infrastructures. We believe that investing time and efforts into training and educating users is a way of securing the social sustainability of a research infrastructure.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":216625377,"openaccessinfo":{"externalids":{"MAG":"3012310104","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Internet of Things (IoT) composed of large number of sensing devices with a variety of features applicable for various applications. In such scenarios, due to low data handling capabilities, limited storage, and security aspects, it is quite challenging to protect networks against illegal information access and utilizes storage efficiently. Though researchers provide various solutions for security and data storage, but a few solutions are appropriate for wireless sensor networks (WSNs)-enabled IoTs. Therefore, a blockchain-based decentralized framework integrated with authentication and privacy-preserving schemes is developed for the secure communication in WSNs-enabled IoTs. Registration, certification, and revocation process are employed for the communication with sensor nodes and base station (BS) in a cloud computing environment. In this scheme cluster heads forward the collected information to the BS. Consequently, BS records all the key parameters on the distributed blockchain and large data is forwarded to clouds for the storage. The revoked certificates of all malicious nodes are eliminated from blockchain by BS. The performance of the proposed scheme is scrutinized in terms of detection accuracy, certification delay, computational, and communicational overheads. The simulated results, comparative analysis, and security validation support the superiority of the proposed solution over the existing approaches.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":226734655,"openaccessinfo":{"externalids":{"MAG":"3080941383","ACL":null,"DOI":"10.1109\/jiot.2020.3019074","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Some of coronary artery anomalies, such as origin of all coronary arteries from three separate ostiums in the right sinus of valsalva, represent a small amount of coronary anomalies. We describe a 63-year-old female patient which coronary angiogram revealed an origin of all coronary arteries from three separate ostiums in the right sinus of valsalva, with significant atherosclerotic plaque at the midportion of the right coronary artery. The stenosis was treated through percutaneous coronary intervention.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19113014,"openaccessinfo":{"externalids":{"MAG":"2151991785","ACL":null,"DOI":"10.4021\/cr29e","PubMedCentral":"5358230","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.4021\/cr29e","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investigated the mRNA and protein expression of nine CKs in melanoma cell lines and tissues, in particular the prognostic significance of CK18 mRNA expression. Reverse transcription (RT)-PCR (CK6\u201310, 14 and 18\u201320), in-situ hybridization (ISH) (CK18), and western blotting (CK18 and pan-cytokeratin AE1\/AE3) were performed on MM cell lines A375, A875, M14, and SK-MEL-1. Eighty MM tissue samples were analyzed by ISH and immunohistochemistry for CK18 expression. The mRNA of CK6\u20138, 10, 14, 18, and 19 (but not CK9 and 20) was detected in one to four of the melanoma cell lines by RT-PCR. CK18 was detected in all four cell lines by RT-PCR, ISH, and western blotting. CK18 mRNA ISH was positive in three of 30 (10.0%), 10 of 25 (40.0%), and 12 of 25 (48.0%) of primary cutaneous, primary mucosal, and metastatic melanomas, respectively (overall positivity: 25 of 80, 31.3%). CK18 immunostaining was only observed focally in eight of 80 (10.0%) of MM tissue samples, and AE1\/AE3 immunostaining was altogether negative. Significantly, CK18 mRNA ISH positivity (but not protein immunohistochemistry) was associated with poorer prognosis by both univariate analysis (P<0.001) and multivariate analysis (relative risk=5.430, 95% confidence interval 2.246\u201313.128, P<0.001). CK18 mRNA could be identified in one-third of melanoma tissue samples and is an adverse prognostic factor. ISH is superior to immunohistochemistry for analyzing CK18 expression in MM.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12087899,"openaccessinfo":{"externalids":{"MAG":"2054271113","ACL":null,"DOI":"10.1097\/CMR.0b013e3283252feb","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In 1975 caries epidemiologic investigations were performed in 1,017 preschoolchildren of Baja, aged 3--6 years. The data were analyzed and compared with those of 620 preschoolchildren of the same city in 1955. A mean increase of 10.9% of the caries frequency (percentage of examinees with caries), and a mean increase of 43.5% of the caries intensity(dmft count per examinee) could be observed in spite of a better vitamin D prophylaxis. The possible cariogenic role of the increased surgar consumption (37.5 kg from 24.4 kg per individual during 20 years) is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26985330,"openaccessinfo":{"externalids":{"MAG":"2131182776","ACL":null,"DOI":"10.1111\/J.1600-0528.1977.TB01627.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: To investigate the value of baseline anti-mutated citrullinated vimentin (MCV) antibody for predicting one-year radiographic progression in patients with rheumatoid arthritis (RA). Methods: Consecutive RA patients were recruited from November 2014 to July 2018 at Department of Rheumatology, Sun Yat-sen Memorial Hospital, Clinical data were collected including disease activity score in 28 joints with four variables including C-reactive protein (CRP).Serum anti-MCV antibody at baseline was detected by enzyme-linked immunosorbent assay. X ray assessment of both hands\/wrists was performed and assessed according to the Sharp\/van der Heijde modified score (mTSS) at baseline and the 12th month. Univariate and multivariate logistic regression analyses were used to identify the risk factors for one-year radiographic progression. Results: Among 220 RA patients recruited, the positive rate of anti-MCV antibody at baseline was 77.7%. Compared with those with negative anti-MCV antibody, RA patients with positive anti-MCV antibody had higher disease activity score in 28 joints with four variables induding CRP [3.8 (2.4, 5.0) vs. 3.1 (2.1, 4.0), P=0.007], more physical dysfunction (21.6% vs. 8.2%, P=0.033) and higher radiographic indicators including mTSS [11 (2, 27) vs. 4 (1, 10), P=0.003], joint space narrowing [JSN, 4 (0, 14) vs. 2 (0, 6), P=0.024] and joint erosion[JE, 5 (1, 18)vs. 3 (0, 5), P=0.003]. After one-year follow-up, sixty-six RA patients (30.0%) developed radiographic progression, the percentage of whom was significantly higher in positive anti-MCV group than that in negative anti-MCV group (33.9% vs.16.3%, P=0.018). Multivariate logistic regression analysis suggested that positive anti-MCV antibody at baseline was an independent risk factor for one-year radiographic progression (OR=2.341, 95%CI 1.002-5.469). Conclusion: Positive anti-MCV antibody at baseline predicts one-year radiographic progression in RA patients. In the future, anti-MCV antibody can be used not only as a supplementary laboratory marker, but also in disease activity assessment and prognosis prediction for RA.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231770082,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3760\/cma.j.cn112138-20200318-00261","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The overtone spectrum of H2S has been recorded by intracavity laser spectroscopy in the 14100-14400 cm-1 spectral region. The rovibrational analysis was performed allowing one to assign not only lines involving the pair of interacting states {(402), (303)} ({(60(+), 0), (60(-), 0)} in local mode notation), but also lines involving the interacting states {(322), (223)} ({50(+), 2), (50(-), 2)} in local mode notation). Indeed, apart from the strong H22 interactions that link the rotational levels of the states (60(+\/-), 0) on the one hand, and the rotational levels of the states (50(+), 2) on the other hand, we observe that the rotational levels of the two pairs of states interact strongly through anharmonic and Coriolis-type resonances. These resonances transfer intensity to lines involving the (50(+), 2) pair of states. Altogether 80 rotational upper-state levels have been observed and reproduced satisfactorily using an Hamiltonian matrix that takes explicitly into account the various interactions and assumes the same vibrational energy and rotational constants for the two components of the local mode pairs. The following band centers have been obtained: nu0 (60(+), 0) = 14291.122 cm-1 and nu0 (50(+\/-), 2) = 14284.705 cm-1. Finally a local mode-type behavior is evidenced by the values of the Hamiltonian constants, and refined vibrational local mode parameters are obtained. Copyright 1998 Academic Press.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24055744,"openaccessinfo":{"externalids":{"MAG":"106137629","ACL":null,"DOI":"10.1006\/JMSP.1998.7581","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Leukemic cells can be recognized and attacked by the immune system. However, emerging studies suggest that dominant peripheral tolerance is a major mechanism of immune escape in disseminated leukemia. Therefore, novel strategies are needed to overcome the tolerance and restore the anti-leukemia T cell function for both leukemia clearance and relapse prevention. Using an established murine acute myeloid leukemia (AML) model, we have demonstrated that systemic administration of recombinant IL-33 dramatically inhibits leukemia relapse and prolongs the survival of leukemia-bearing mice in a CD8+ T cell dependent manner. Exogenous IL-33 treatment enhanced anti-leukemia activity by increasing the expansion and IFN- g production of leukemia-reactive CD8+ T cells. Moreover, IL-33 induced dendritic cell (DC) maturation and activation in favor of its cross presentation ability to evoke a vigorous anti-leukemia immune response. Finally we found that the combination of PD-1 blockade with IL-33 further prolonged the survival with half of the mice achieving complete regression. Our data establish a role of exogenous IL-33 in reversing T cell tolerance and suggest its potential clinical implication into leukemia immunotherapy.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":255730300,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.196.supp.73.2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper the multicarrier direct-sequence code-division multiple access (MC DS-CDMA) using space-time spreading assisted transmit diversity is investigated in the context of broadband wireless communi-cations systems constructed based on the generalized approach to signal processing in noise over frequency-se-lective Rayleigh fading channels. We consider the issue of parameter design for the sake of achieving high-ef-ficiency communications in various dispersive environments. In contrast to the conventional MC DS-CDMA wireless communication system employing the time (T)-domain spreading only, in the present paper the broad-band wireless MC DS-CDMA wireless communication schemes employ both the time (T)-domain and frequen-cy (F)-domain spreading, i.e., employ the TF-domain spreading. The bit-error rate (BER) performance of the space-time spreading assisted broadband MC DS-CDMA wireless communications system is investigated for down-link transmissions associated with the single user and multiuser generalized detectors and is compared with that of the single user correlation detector and the multiuser decorrelating detector. Our study demonstra-tes that with appropriately selecting the system parameters, the broadband MC DS-CDMA wireless communi-cation system using the space-time spreading assisted transmit diversity constitutes a promising downlink tran-smission scheme. This scheme is capable to support ubiquitous communications over diverse communication environments without the BER performance degradation","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":244258272,"openaccessinfo":{"externalids":{"MAG":"3202334985","ACL":null,"DOI":"10.37394\/23204.2021.20.21","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/doi.org\/10.37394\/23204.2021.20.21","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Revista Ci\u00eancia & Sa\u00fade Coletiva has dedicated publications to the theme of evaluation assessing mainly methodological approaches and alternative designs for evaluative research. This edition seeks to contribute to the dissemination of research work carried out in order to foster debate on the problems faced by the SUS in the development of health management and thus provide more objective decision-making and effective alternatives in pursuing the principles of universality, comprehensiveness and equity. The papers presented cover topics such as: the potential provided by the use of evaluation for decision-making with greater effectiveness; methodologies for creating a monitoring panel applicable to the management of the SUS; basic guidelines necessary for the evaluation of performance; analysis of the scope and limits of decentralized management; budgetary\/financial evaluation methodologies; the identification of key steps for the planning and monitoring of municipal management and the conditions necessary for the evaluation of policy, and the creation of strategic agendas. In addition to disseminating theoretical and experimental approaches attempted in the field of evaluation of health, this edition also reflects part of the effort made by members of the Abrasco Evaluation WG in order to foster the performance of evaluations at all levels of management. This work had the important and significant contribution of the Department for Strategic and Participative Management of the Ministry of Health in 2010, via the Department of Monitoring and Evaluation of Management of the SUS. We are aware that despite our best efforts it was not possible to cover all the important aspects of management that would benefit from evaluation work. However, a careful reading of the articles will enable managers and researchers to identify important contributions that evaluation can offer to improve the management of services, systems and programs in the SUS.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10621061,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo evaluate the feasibility and safety of a new style of Laparoscope and Endoscope Cooperative gallbladderpreserving Surgery (LECS), an improved method of minimally invasive gallbladder-preserving polypectomy.\n\n\nSTUDY DESIGN\nAn experimental study.\n\n\nPLACE AND DURATION OF STUDY\nDepartment of General Surgery, The Second Affiliated Hospital of Soochow University, China, from January 2009 to July 2013.\n\n\nMETHODOLOGY\nClinical data of patients subjected to LECS and Laparoscopic Cholecystectomy (LC) was analysed. The inclusion criteria were normal size clear gallbladder bile with total volume (FV) of the gallbladder = 15 - 25 ml, the Residual Volume (RV) = 5 ml, and the Emptying Figure (EF) > 75%, with polyps diagnosed definitively by B-type ultrasonic imaging or CTdesirous of preserving gallbladder. Exclusion criteria were a history of midsection surgery, serious diseases of any organ, hepatic injury, or coagulation disturbance. Mean hospital stay and complications were also noted. Independent sample t-test, the frequency comparison used chi-square test (N > 5), and Fisher's exact test (N < 5) were used for statistical test.\n\n\nRESULTS\nThe mean hospital stay after LECS was 3.50 \u00b10.31 days, and 3.50 \u00b10.31 days for the LC group. The mean age in LC and LECS group was 50 \u00b125.4 and 44 \u00b112.1 years, respectively. Complications after operation in the LECS were indigestion and diarrhea; LC group had indigestion (9.33%), diarrhea (10.67%), and gastroesophageal reflux (6.6.7%). In the 3 months follow-up after discharging from the hospital, no patient had recurrence of any gallbladder disease; at 1 year follow-up, 1 patient (1.28%) developed cholesterol crystals; at 3-year follow-up, 3 cases (3.84%) were found to have recurring polyps (2~4 pieces), and 2 (2.56%) patients developed cholesterol crystals.\n\n\nCONCLUSION\nMinimally invasive gallbladder-preserving polypectomy which used a CHIAO cholecystoscopy compared with a laparoscope is safe, feasible, and can effectively reduce the vestiges and recrudescence of polyps in gallbladderpreserving surgery.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10463585,"openaccessinfo":{"externalids":{"MAG":"2418665680","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aims of this study were to assess the processing window of hypromellose acetate succinate (HPMCAS) as a polymeric carrier for hot-melt extrusion, and to investigate the effect of screw configuration and processing parameters on the physicochemical properties of HPMCAS extrudates. The processability was investigated using a Brabender\u00ae mixer and a Pharma 11 Twin Screw Extruder. HPMCAS extrudates were characterized with regard to glass transition temperature, true density, yellowness index, crystallinity, morphology, and free succinic acid\/acetic acid\/succinoyl group\/acetyl group content. The specific energy input and mean residence time were also calculated and correlated to the physicochemical properties of final extrudates. Additionally, the effect of the die opening size of the twin screw extruder was investigated. The glass transition temperature of HPMCAS was found to be 137 and 133\u00b0C, using dynamic mechanical analyzer and oscillatory rheometer, respectively. HPMCAS demonstrated a shear thinning behavior at all temperatures tested (150, 160, and 170\u00b0C). The process conditions, screw configurations, as well as the diameter of die opening significantly affect the amount of free acetic acid and succinic acid. With a modified screw configuration and 1-mm die, the amounts of free acetic acid and succinic acid from the material processed at 180\u00b0C were 0.114% and 0.337%, respectively. Moreover, when the die was removed, the amounts of free acetic acid and succinic acid were further reduced to 0.084% and 0.294%, respectively. In conclusion, we successfully extruded HPMCAS at a temperature as low as 130\u00b0C and up to 180\u00b0C without any significant thermal degradation.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-30":1}},"corpusid":138251036,"openaccessinfo":{"externalids":{"MAG":"2265380974","ACL":null,"DOI":"10.1002\/ADV.21652","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a genome assembly from an individual male Agriphila tristella (the common grass-veneer; Arthropoda; Insecta; Lepidoptera; Crambidae). The genome sequence is 802 megabases in span. Most of the assembly (99.83%) is scaffolded into 23 chromosomal pseudomolecules with the Z sex chromosome assembled. The mitochondrial genome was also assembled and is 15.3 kilobases in length.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":254805661,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.12688\/wellcomeopenres.18568.1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.12688\/wellcomeopenres.18568.1","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Complex disorders manifest by the interaction of multiple genetic and environmental factors. Through the construction of genetic modules that consist of highly co-expressed genes, it is possible to identify genes that participate in common biological pathways relevant to specific phenotypes. We have previously developed tools MAGI and MAGI-S for genetic module discovery by incorporating co-expression and protein-interaction networks. Here we introduce an extension to MAGI-S, denoted as Merging Affected Genes into Integrated Networks - Multiple Seeds (MAGI-MS), that permits the user to further specify a disease pathway of interest by selecting multiple seed genes likely to function in the same molecular mechanism. By providing MAGI-MS with pairs of seed genes involved in processes underlying certain classes of neurodevelopmental disorders, such as epilepsy, we demonstrate that MAGI-MS can reveal modules enriched in genes relevant to chemical synaptic transmission, glutamatergic synapse, and other functions associated with the provided seed genes. Availability and implementation MAGI-MS is free and is available at: https:\/\/github.com\/jchow32\/MAGI-MS","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":237550424,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/bioadv\/vbac025","PubMedCentral":"9710684","ArXiv":null},"license":"CCBY","url":"https:\/\/academic.oup.com\/bioinformaticsadvances\/article-pdf\/2\/1\/vbac025\/43513233\/vbac025.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo explore the expression of PI3K in esophageal squamous cell carcinoma (ESCC) and its clinical significance.\n\n\nMETHODS\nThe expression of PI3K proteins was detected by immunohistochemical SP staining in 91 ESCC tissues and normal mucosa of 10 cases. RT-PCR was used to detect the expression of PI3K mRNA in 30 ESCC tissues and adjacent normal mucosa. The relation between PI3K expression and the clinicopathological features and prognosis was analyzed.\n\n\nRESULTS\nThe positive rate of expression of PI3K protein in ESCC was 86.8%, significantly higher than that in normal esophageal mucosa (10.0%, P<0.001). There was a positive correlation between P13K expression and the degrees of differentiation, invasion depth, and clinical stage. No positive correlation was found between the expression of PI3K protein and age, gender and lymph node metastasis (P>0.05). The poorer is the differentiation of ESCC, the stronger is expression of PI3K protein (r = 0.351, P<0.05); the deeper is the invasion depth of ESCC, the stronger is expression of PI3K protein (r = 0.210, P<0.05); and the higher is the clinical stage of ESCC, the stronger expression of PI3 K protein (r = 0.240, P<0.05). RT-PCR results demonstrated that the level of PI3K mRNA expression in ESCC was 0.675 +\/- 0.029, significantly higher than that in the adjacent normal mucosa (0.349 +\/- 0.073, P<0.05). The high expression of PI3K mRNA was correlated with poor differentiation, deep invasion and clinical stage of ESCC (P<0.05). The result was consistent with SP staining immunohistochemistry. By Kaplan-Meier analyses, following factors were observed to be significantly associated with prognosis: PI3K expression, the degrees of differentiation, invasion depth, lymph node metastasis, clinical stage, tumor embolus and stump invaded (all P<0.05). The multivariate analysis showed that clinical stage (P<0.05), invasion depth (P<0.05) and stump invaded (P<0.05) were significantly correlated with the prognosis. The multivariate analysis of Cox model showed that PI3K was not an independent prognostic indicator of prognosis (chi2 = 1.235, P = 0.266).\n\n\nCONCLUSIONS\nThe expression levels of PI3K protein and mRNA in ESCC tissues are significantly increased and PI3K plays a role in the carcinogenesis and development of ESCC. The enhanced PI3K expression may serve as a reference index indicating a poor prognosis in ESCC.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24944510,"openaccessinfo":{"externalids":{"MAG":"2394973136","ACL":null,"DOI":"10.3760\/CMA.J.ISSN.0253-3766.2011.08.009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Purpose: Human capabilities in medicine, including communication skills, are increasingly important within the complex, challenging and dynamic landscape of healthcare. Supporting medical students to manage unavoidable role-related stressors adaptively may help mitigate the anguish that is too commonly reported among the profession. We developed a model, \"MaRIS\", underpinned by contemplative pedagogy, to support medical students to enhance their human capabilities, across all three domains of Bloom's taxonomy, and their personal resilience. It is the first to integrate Mindfulness, affective Reflection, Impactive experiences and a Supportive environment into medical curriculum design. Here, we describe the theoretical basis underpinning MaRIS and present a preliminary study to evaluate its impact on students' subjectively-rated capabilities. Materials and Methods: A questionnaire capturing self-ratings of competence, empathy and resilience, as well as impressions of their experiences, was administered to foundation year medical students before (T0), during (T1) and after delivery (T2). Results: Fifty-five students completed the survey at all time points. Mean scores for all domains increased significantly from T0 to T1 and from T0 to T2. Free-text comments suggest learning impact across the cognitive, psychomotor and affective domains. Conclusions: MaRIS appears to facilitate medical students' establishment of the foundations for building the human capabilities and personal resilience required for professional practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204545966,"openaccessinfo":{"externalids":{"MAG":"2980168064","ACL":null,"DOI":"10.1080\/0142159X.2019.1670340","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background The Falsified Medicines Directive (FMD) and the Delegated Regulation (DR) 2016\/161 will require, from 9 February 2019, hospital pharmacies to check the authenticity of each medicinal product they receive. Our hospital participates in a test with the National Medicines Verification Organisation to evaluate possible strategies, compatible with legislation, for the implementation of serialisation. Purpose The aim of the first test is to evaluate the feasibility of decommissioning of each unique identifier at the reception of medicinal products in the pharmacy. Material and methods During 14 days (summer 2018), the pharmacy technician scanned the data-matrix of each box received with an Optel certa tabletop (possibility of switching between vertical and handheld scanner). Quantitative indicators (number of boxes received, number of serialised drugs in circulation, products with a non-compliant data matrix) were recorded. The scanning time of each carton was measured and the equipment's ergonomics evaluated. Results During the study, the pharmacy received an average of 822 boxes\/day (min: 273; max: 1737), of which 90% were in the scope of the FMD and the RD. The average scanning time per pack was 5\u2009s, totalling an average of 56\u2009minutes\/day to scan all boxes. Only 3\/530 medications displayed a serial number, while three of them (nicardipine, pemetrexed, midazolam) had a non-readable data-matrix (colour inversion) on their packaging and thus could not be scanned. The Optel certa tabletop and its software are considered easy to use. But the manoeuverability and malfunctions of the handheld scanner contributed to inflate the scanning time. Conclusion This first test demonstrated the technical feasibility of decommissioning boxes on their reception in real working conditions. The connection to the National Medicines Verification System was not effective during the test, so the upload time between interfaces could not be evaluated. The imposing equipment leads to opting for mobile and compact scanning devices. Decommissioning at reception confronts us with repeated interruptions of tasks (deliveries, phone calls \u2026) but avoids the storage of non-authentic and non-conforming boxes. A second decommissioning test just before dispensing to patients is planned to assess the feasibility of this scenario. References and\/or acknowledgements Falsified Medicines Directive. Delegated Regulation 2016\/161. No conflict of interest.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":87448289,"openaccessinfo":{"externalids":{"MAG":"2921143503","ACL":null,"DOI":"10.1136\/ejhpharm-2019-eahpconf.62","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ejhp.bmj.com\/content\/ejhpharm\/26\/Suppl_1\/A28.3.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Sepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. We investigated the effects of clinically relevant plasma concentrations of the calcium sensitizer levosimendan during the first 6 h of endotoxemia in a model of experimental sepsis in pigs (21.8-44.0 kg). Levosimendan given to endotoxemic pigs receiving moderate volume resuscitation elicited tachycardia, hypotension and myocardial ischemia, as evidenced by a negative myocardial lactate flux (study I). Likewise, compared to non-treated controls, levosimendan did not improve systemic or hepatosplanchnic perfusion during endotoxin shock: the animals developed signs of tissue hypoperfusion with elevated blood lactate and low oxygen venous saturations (study II). Aggressive volume resuscitation before levosimendan treatment induced a hyperdynamic state that was sustained by levosimendan and norepinephrine treatment, whereas control animals gradually developed shock. Nevertheless, splanchnic blood flow was redistributed and the superior mesenteric artery, the hepatic artery and the portal vein blood flows (PVF) decreased. Similarly to study II, there were signs of systemic and hepatosplanchnic tissue hypoperfusion. In contrast, administration of dobutamine and norepinephrine, increased cardiac output (CO) and oxygen delivery, maintained PVF and improved tissue perfusion (study III). Load independent measurements of cardiac function showed that systolic function was actually enhanced during the first 2 h of sepsis, whereas diastolic function was depressed in both ventricles. The initial decrease seen in CO was a result of volume depletion, and recovered with aggressive volume resuscitation. Although endotoxin-induced lung injury caused early right ventriculovascular uncoupling and increased right ventricular (RV) myocardial oxygen demand, right coronary artery blood flow improved markedly with resuscitation, maintaining adequate myocardial perfusion (study IV). In resuscitated septic pigs, levosimendan supported RV function by increasing RV contractility at a low energy cost. CO and left ventricular ejection fraction increased, and right ventriculovascular coupling and mechanical efficiency tended to improve (study V). In conclusion, early treatment with levosimendan during resuscitated sepsis can increase CO and improves RV contractility at a low energy cost, but it does not improve hepatosplanchnic perfusion significantly, which is better achieved with dobutamine-norepinephrine. In addition, because levosimendan is an inodilator, its use in sepsis should be restricted to thoroughly fluid-resuscitated subjects.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":70945307,"openaccessinfo":{"externalids":{"MAG":"1806311562","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With rare exceptions, natural evolution is an extremely slow process. One particularly striking exception in the case of protein evolution is in the natural production of antibodies. Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM). Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation). The avian B cell line DT40, a cell line which is highly amenable to genetic manipulation and exhibits a high rate of targeted integration, utilizes both GC and SHM. Targeting the DT40's diversification machinery onto transgenes of interest inserted into the Ig loci and coupling selective pressure based on the desired outcome mimics evolution. Here we further demonstrate the usefulness of this platform technology by selectively pressuring a large shift in the spectral properties of the fluorescent protein eqFP615 into the highly stable and advanced optical imaging expediting fluorescent protein Amrose. The method is advantageous as it is time and cost effective and no prior knowledge of the outcome protein's structure is necessary. Amrose was evolved to have high excitation at 633 nm and excitation\/emission into the far-red, which is optimal for whole-body and deep tissue imaging as we demonstrate in the zebrafish and mouse model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17498082,"openaccessinfo":{"externalids":{"MAG":"2015765406","ACL":null,"DOI":"10.1371\/journal.pone.0107069","PubMedCentral":"4156574","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0107069&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A recent issue of the journal Bioethics discussed whether conscientious objectors within the healthcare context should be required to give their reasons to a specially convened tribunal, who would have the power to reject the objection. This is modeled on the context of military conscription. Advocates for such a tribunal offer two different justifications, one based on determining the genuineness of the applicant's beliefs, the other based on determining their reasonableness. I limit my discussion to a doctor's objection to abortion in the UK, and argue against both justifications: I thereby defend the status quo, where such doctors are not formally required to defend their beliefs. My argument has to do with the particular nature of the abortion debate in the UK, and the more general nature of ethical disagreement.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":44362182,"openaccessinfo":{"externalids":{"MAG":"2087183704","ACL":null,"DOI":"10.1136\/medethics-2015-102692","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"House dust mites play an important role in causing various allergic disorders. Many factors like temperature, humidity as well as different microclimatic conditions may influence mite growth. The aim of this study was to analyse the mite fauna of Kolkata, West Bengal, India. House dust was collected from 20 selected houses located in and around Kolkata from January 2017 to December 2017. House dust samples were processed following the flotation technique and house dust mites were isolated from all the samples surveyed. A total of 51 species belonging to 34 genera and 17 families were isolated from positive samples. Dermatophagoides pteronyssinus, Blomia tropicalis and Cheyletus malaccensis were present in all positive samples. Most abundant mite in house dust was Dermatophagoides pteronyssinus, constitute 47% of the mites collected from dust samples. Amblyseius longispinosus was first time reported from Indian house dust.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":234678593,"openaccessinfo":{"externalids":{"MAG":"3124687906","ACL":null,"DOI":"10.47121\/ACAROLSTUD.786681","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Almost ten years after the detection of the Xylella bacterium in southern Apulia (Saponari, 2013), the landscape now appears almost entirely desiccated, missing an organic vision of the future. The systematic estrangement between the different actors of knowledge and the substantial administrative immobilism has produced today a political, economic and environmental starvation. Our aim is to provide an adequate reading of the stalemate in the descriptive grids proper to the sociological analysis of socio-environmental (De Marchi, 2004) and botanical conflicts (Sheikh and Gray, 2018)\u00a0 which opens up to the social action ofthe other-than-human world (Puig de la Bellacasa, 2017b; Pyyhtinen, 2016).\u00a0 \nThe material of a double field research - an ethnographic one underway since 2018; and a more recent qualitative sociological research, highlights the role of olive growers, as well as non-profit associations active in reforestation actions, and supports the hypothesis of at least two different interpretive paths.\u00a0\u00a0 \nThe representations of the crisis adopted by social groups in the infected area, are investigated starting from the definition of conflict issues on the landscape and the economy in terms of aspirational capacity (Appadurai, 2004; De Leonardis, 2012) of local communities, such as to manifest a rupture of identity constructions and social cohesion following an extreme event. Thus, if the ecological disaster succeeded on the one hand in undermining the vulnerability of social groups and their ability to renegotiate their understanding of the disaster and their relationship with non-human actors, the ethnographic research conducted also shows another side. Numerous social entities have allowed a regenerative dimension to emerge from the disaster, characterized by a critical reinterpretation of past agricultural practices and the ability to question conventional boundaries between nature and culture. The challenge of communities not only to build, but to imagine a new landscape, has given rise in Capo Leuca and few but widespread areas of Salento to experimental practices of agro-forestry regeneration of the highest social relevance (Papadopoulos 2018), which also interrogate through the commons the economic and political agendas of trade associations and the region on the one hand, and speculators on the other.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":244618993,"openaccessinfo":{"externalids":{"MAG":"3207687110","ACL":null,"DOI":"10.6093\/2723-9608\/8002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on Global Tuberculosis Control WHO 2012, Indonesia went up from fifth to forth rank after India, China, and South Africa, obviously problem within restraint of Tuberculosis has increased. On 2008 North Sulawesi classified Pulmonary TB diseases as the top 10 infectious diseases with a prominent number of 1,571 cases. Manado City on 2012 Pulmonary Tuberculosis with BTA positive number was 1.645 cases. Basically, this condition exhibit an efforts development of healthy in order to improve risk factors for Pulmonary TB until now has not been entirely successful. The type of this research is cross sectional that purpose to know risk of factors (age, gender, education, employment, level of income, knowledge and the side effects of anti-tuberculosis drugs related with obedience of treatment pa-tients with Pulmonary Tuberculosis in five health centers in the city of Manado. There were 171 samples taken from a total population of 119 people. Data obtained from direct interviews using questionnaires. The statistical test used was Chi square. The result of research indicates that the variable, which relates with treatment compliance of TB pa-tient, is education. (p=0,000) and knowledge (p=0,000). Variable that are not related to obedience of treatment TB patients are age, gender, education, occupation, level of income and side effect OAT (p=0,05). Keywords: Clean and Health Behaviour, Knowledge, Attitude and Behaviour","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70395540,"openaccessinfo":{"externalids":{"MAG":"1540755622","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In recent years, marine oil pollution resulting from exploitation spills and accidents during oil transportation and use has affected the marine ecosystem safety, and oil polluted sea water remediation becomes a global problem. Peanut shell possesses a good property of adsorption pollutants and it can be easily obtained from the abundant produce of peanut all around the world. This experiment used carbonized peanut shell (CPS) as adsorbent; aiming to purify oil polluted sea water and explore optimal adsorption conditions and effects. Six sets of experiments were done under the initial oil concentration of 1.35 mg\/L and CPS dosages of 0, 6.67, 13.33, 20, 26.67, 33.33 g\/l, separately. Seventy percent of oil was removed under the ideal dosage of 13.33 g\/l, getting the minimum oil concentration of 0.39 mg\/l. Another six sets of experiments were also done under the adsorption time of 0 h, 1 h, 2 h, 3 h, 4 h, 5 hand the same CPS dosage of 13.33 mg\/l. The ideal removals of Chemical Oxygen Demand (COD) (35.5%) and oil (71%) were obtained after 3 hours adsorption, while the highest COD removal gets to","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":235598309,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Quantum dots (QDs) are a unique class of emitters with size-tunable emission wavelengths, saturated emission colors, near-unity luminance efficiency, inherent photo- and thermal- stability and excellent solution processability. In the past few years, efficiency and lifetime of quantum-dot light-emitting diodes (QLEDs) achieved tremendous progress. These encouraging facts foreshadow the commercialization of QLEDs, which promises an unprecedented generation of cost-effective, large-area, energy-saving, wide-color-gamut, ultra-thin and flexible displays. Here we review our activities associated with QLEDs, including exciton-generation mechanisms, material chemistry of charge-transporting layers and device engineering.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225270946,"openaccessinfo":{"externalids":{"MAG":"3080748845","ACL":null,"DOI":"10.1117\/12.2566976","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objectives. Levosimendan is an inodilator indicated for acute heart failure (AHF). Its vasodilatory and anti-ischemic effects are mediated by the opening of ATP-dependent potassium channels (KATP channels). Diabetes mellitus is common in AHF patients and sulfonylureas are often prescribed. Sulfonylureas act by blocking the KATP channels. An interaction between levosimendan and sulfonylureas has been shown in preclinical models and could be hypothesized in clinical practice. Design. We produced a pooled analysis of six randomized levosimendan trials (in total of 3004 patients of which 1700 were treated with levosimendan and 226 both with levosimendan and sulfonylureas) with the aim to study the influence of concurrent sulfonylurea treatment to the levosimendan effects. Invasive and non-invasive hemodynamics, biomarkers (BNP), adverse events related to myocardial ischemia, and survival were evaluated. Results. In our relatively small data set, we could not detect any clinically relevant interactions between the sulfonylureas and levosimendan. Similar decreases in systolic and diastolic blood pressure, pulmonary capillary wedge pressure and BNP, and similar survival and adverse event profiles were seen in sulfonylurea users and non-users exposed to levosimendan. Conclusions. Concomitant use of sulfonylureas with levosimendan does not attenuate the hemodynamic or other effects of levosimendan.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2013-20":1,"unknown":2}},"corpusid":27566875,"openaccessinfo":{"externalids":{"MAG":"2035778415","ACL":null,"DOI":"10.3109\/14017431.2012.725206","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The emergence of service providers and brokers who are independent of network providers has opened the way to a spot market in free network resources: it is under everybody's eyes that market enabled service provision based on Service Level Agreements (SLAs) will be essential for the delivery of many services such as bandwidth on demand. In order for those services to be created, configured and delivered dynamically via automated SLAs, a market enabling mechanism is required that is sufficiently flexible to convey the varying information requirements of the various stakeholders involved in the service delivery chain, together with their internal processes. In this paper an innovative framework for the negotiation of services with quality assurances is presented. The study is conducted keeping an eye on the latest standard proposals coming from the electronic business research community, with respect to both the modeling methodology and the actual design for implementation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":33359171,"openaccessinfo":{"externalids":{"MAG":"2083447064","ACL":null,"DOI":"10.1145\/568760.568875","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This work aims to explore the use of a new gesture-based interaction built on automatic recognition of Soundpainting structured gestural language. In the proposed approach, a composer (called Soundpainter) performs Soundpainting gestures facing a Kinect sensor (Microsoft). Then, a gesture recognition system captures gestures that are sent to a sound generator software. The proposed method was used to stage an artistic show in which a Soundpainter had to improvise with 6 different gestures to generate a musical composition from different sounds in real time. The accuracy of the gesture recognition system was evaluated as well as Soundpainter's user experience. In addition, a user evaluation study for using our proposed system in a learning context was also conducted. Current results open up perspectives for the design of new artistic expressions based on the use of automatic gestural recognition supported by Soundpainting language.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":198311912,"openaccessinfo":{"externalids":{"MAG":"2953710094","ACL":null,"DOI":"10.5281\/zenodo.3672866","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/hal.science\/hal-02162875\/document","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Mexico has more than 40 years of researching, investing, and obtaining electric power through wind energy. Within the country, there are highly windy areas, such as the Isthmus of Tehuantepec or the state of Tamaulipas, and there are about 2500 MW installed and 70,000 MW tested, all onshore. There are still no offshore wind farms in Mexico, despite having two main coasts, the East and the West, with the Gulf of Mexico and the Pacific Ocean, respectively. Although the Mexican coastal states of the Gulf of Mexico are Tamaulipas, Veracruz, Tabasco, Campeche, and Yucat\u00e1n, this work focuses on the study and feasibility of offshore wind energy use on the coasts of the states of Tabasco, Campeche, and Yucat\u00e1n. This is because of the availability of data in that region; however, sustainability criteria that can be used in other regions are also presented. MERRA-2 and ERA5 data were used employing WAsP and Windographer software. It was found that the capacity factor in the area of Tabasco, Campeche, and Yucat\u00e1n is 32%, 37%, and 46%. It can be noted that, in the WF100% scenario, each of the wind farms could contribute more than 35% of the region's electricity consumption; those of Campeche and Yucat\u00e1n stand out with contributions of more than 70%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":2,"2024-22":1}},"corpusid":248791134,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/su14105877","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2071-1050\/14\/10\/5877\/pdf?version=1652358468","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"One third of all extranodal lymphomas are located at the gastrointestinal tract, and 10-20% of gastrointestinal lymphomas are located in the colon. Primary colorectal lymphomas constitute 0.1-0.5% of all large bowel malignancies. The most common type of lymphoma is diffuse large B cell lymphoma. It is twice as common in males than females and generally is encountered in 6 th and 7 th decade of life. Abdominal pain and weight loss are the most common symptoms, and because these symptoms are non-specific, time of diagnosis is usually delayed. Isolated surgical therapy or chemotherapy can be employed, and combination treatment might be preferred. In this case report, we present a colonic non-Hodgkin lymphoma patient who was admitted with weight loss and abdominal pain. This case reports on a patient who was younger than what has generally been reported in the literature","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":203418849,"openaccessinfo":{"externalids":{"MAG":"2114268571","ACL":null,"DOI":"10.17940\/ENDOSKOPI.74777","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Previous studies have shown that spatial memory and semantic aids can help users learn and remember gestural commands. Using the body as a support to combine both dimensions has therefore been proposed, but no formal evaluations have yet been reported. In this paper, we compare an on-body interaction technique (BodyLoci) to mid-air Marking menus in a virtual reality context. We consider three levels of semantic aids: no aid, story-making, and story-making with background images. Our results show important improvement when story-making is used, especially for Marking menus (28.5% better retention). Both techniques performed similarly without semantic aids, but Marking menus outperformed BodyLoci when using them (17.3% better retention). While our study does not show a benefit in using body support, it suggests that inducing users to leverage simple learning techniques, such as story-making, can substantially improve recall, and thus make it easier to master gestural techniques. We also analyze the strategies used by the participants for creating mnemonics to provide guidelines for future work.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":29157747,"openaccessinfo":{"externalids":{"MAG":"2797722071","ACL":null,"DOI":"10.1145\/3206505.3206524","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.archives-ouvertes.fr\/hal-01764757\/file\/bodyloci-hal-v1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Anatomy is a self depiction, a series of body \nimages in the manner of self portraits, created without \nrecourse to a mirror image. The work comprises largescale \ncoloured etchings, which are assemblages of body \nprints and collaged 'found' anatomical drawings. The \nsymbolism refers to the pre-Oedipal relation. This \nissue is met in Julia Kristeva's discussion of the semiotic \nchora, Luce Irigaray's discussion of Merleau-Ponty's \nanalysis of vision, and other sources that I have \nreferred to which reconsider the Lacanian narrative in \npsychoanalysis. \nMuch of the debate about women's place in the \nsymbolic realm has been conducted at the level of \nlanguage. Anatomy contributes a visual parallel: a \nmove to subvert the symbolic centrality of the female \nbody as a passive plane or surface upon which \nmeanings are projected, and to reconfigure a body \nimage which acts as an active signifying entity. \nThe pictorial solution that I arrived at utilises \nback-lighting to activate the body images, adding a \nvisceral, immediate, and deliberately auratic element to \nthe etched images. The illumination notionally returns \nthe viewer's gaze and creates an intimacy - something \nlike a caress - which alludes to the pre-Oedipal \nmaternal gaze.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":193511220,"openaccessinfo":{"externalids":{"MAG":"1009213293","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: This study evaluates the prevalence of diastolic dysfunction (DD) in several stages of chronic kidney disease (CKD) in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: 107 ADPKD patients performed echocardiographic and Doppler studies and a tissue Doppler imaging (TDI) study. Patients were divided in three groups: group 1, 57 patients with CKD stage I, group 2, 37 patients in stages II and III, and group 3, 13 patients with CKD stages IV and V (not on dialysis). Results: In transmitral Doppler, 1 patient in group 1 compared to 5 in group 2, and 4 in group 3 exhibited DD (p < 0.005); moreover, E\/A ratio decreases progressively from group 1 to 3 (p < 0.0001). In TDI, DD was observed in 8 patients in group 1, 17 in group 2, and 8 in group 3 had DD (p < 0.001). Em velocity, the best TDI parameter for DD, correlated with age, renal function and blood pressure. When adjusted for age, increased left ventricular mass index and decreased renal function were independent risk factors of DD. Conclusions: DD occurred progressively as renal function deteriorates in patients with ADPKD and this effect is independently related to age and blood pressure.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":35771796,"openaccessinfo":{"externalids":{"MAG":"1988136330","ACL":null,"DOI":"10.1159\/000104092","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The positive influence of the upper extremities swing on the effect of take-off in jumping is well known. Such movement is used in vertical jump, long jump, high jump and others. This effect causes increase of the ground reaction force produced by each segment (Luhtanen and Komi, 1978) and in addition the upper extremities swing has also a coordinative meaning, for example while double overarm movement at running is to be change into parallel movement at take off (high jump), There are also such situations like in basketball and volleyball (Wielki and Dangre, 1983; Wilkerson, 1983) in which the desired arms swing is limited by the other task which has to be performed like blocking or passing the ball. \nLoss in the height of the vertical jump -while the arms swing is not executed -and diminishing ground reaction force at take-off and the possible changes in biomechanical variables during take-off, are the object of this experiment.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":73629982,"openaccessinfo":{"externalids":{"MAG":"563828921","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article is a study to determine the validity and reliability model of vocational teacher efforts to support graduates' work readiness using outer model analysis. The model points out relationship of factors associated with vocational teachers with graduate work readiness. Data was collected using a questionnaire method with a survey design of 60 vocational teachers (Audio Video Engineering) in Yogyakarta. Development of hypotheses and questionnaires with a theory testing approach. Convergence validity in terms of outer loading shows that there are WR1 (mastering basic skills) and WR7 (interest) indicators which have values below 0.7. Based on the AVE value all indicators are greater than 0.5. Discriminant validity shows that all values in each construct are greater than values in other constructs. Based on AVE and cross-loading values, as well as construct representation, WR1 and WR7 are maintained. Both the composite reliability and the Cronbach's alpha value are \u2265 0.70, so reliability is accepted. From these results, the instrument can be used for further research because it has been valid and reliable. The indicators on the construct variables can be used to analyze the relationship of on the efforts of Vocational Teachers (Audio Video Engineering) to support graduates' work readiness.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":221354367,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Peak is an important feature in Synthetic Aperture Radar(SAR), which represents essence of scattering centre. There are two general approaches in the literature to extract peak. One way is to extract peak after speckle suppression filtering. Using this method, the extracted feature is in accurate, and the algorithm is more complicated. Another is that detecting the amplitude of the peak directly. In order to have a fast and accurate peak extraction, we proposed using the Sinc peak model algorithm in this paper. It directly extracts peak features from the original SAR image without any noise suppression filtering, which is instead of Gauss mask function. The estimation parameters of peaks use QE theorists. Finally, we can get accuracy three parameters to describe peak features. Analytic fluctuation of parameters is compared with Gauss model peaks using truth SAR images. Experimental demonstrate that the new algorithm is more effective than others for extracting peak features in SAR images.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":59057290,"openaccessinfo":{"externalids":{"MAG":"2292832791","ACL":null,"DOI":"10.5194\/ISPRSARCHIVES-XL-7-W4-45-2015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It principally affects the cooler parts of the body, mainly skin and peripheral nerves. Leprosy involves wide range of biochemical as well as immunological changes in the body including trace elements such as zinc, copper and magnesium. After iron, zinc is the second most abundant trace element in the body. \nThis study has been undertaken to correlate with clinical presentations wherever possible and to investigate the level of serum zinc in leprosy. Study included 63 newly diagnosed leprosy. Cases were further distributed according to clinical subtypes and were compared to controls. Venous blood samples were collected and estimation of serum zinc level has been done with serum. \nMaximum patients detected were of Intermediate Leprosy (26.9) where as lesser (1.58)were of Histoid type. Pure tuberculoid and Indeterminate leprosy group showed minimum decrease and pure lepromatous and Erythema nodosum leprosum group showed maximum decrease in Serum Zinc level i.e. leprosy patients with increased bacterial load have decreased serum zinc levels. This suggests that there could be a correlation of serum zinc levels and the bacillary load.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":6473258,"openaccessinfo":{"externalids":{"MAG":"2276424107","ACL":null,"DOI":"10.9734\/bpi\/nfmmr\/v1\/11351d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The influence of laser processing parameters on mechanical properties and microstructure of pure titanium models made by selective laser melting is investigated. The density of the models can reach higher than 95% under proper conditions. Although the tensile strength test shows results comparable to the wrought material, the impact and torsional fatigue strengths are low because of porosity and oxygen pick-up suggested by increasing of hardness. Hot isostatic pressing allows almost full densification and greatly improves mechanical properties.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":44019689,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Polarized positron and electron beams are ideal for searching for new physics at the International Linear Collider (ILC). In order to properly orient and preserve the polarization of both beams at the interaction point (IP) the beam polarization must be manipulated by a series of spin rotators along the beam line. Furthermore, the polarization for both beams should be known with a relative uncertainty of about 0.5% or better, therefore, all sources of depolarization along the ILC should be identified. We report on a spin rotator design for the ILC and polarization studies between damping ring extraction and the IP.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":19767889,"openaccessinfo":{"externalids":{"MAG":"2992008755","ACL":null,"DOI":"10.1109\/PAC.2007.4441121","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have investigated the site of synthesis of the 2\u2032,3\u2032\u2010cyclic nucleotide 3\u2032\u2010phosphodiesterases (CNPs I and II) in rat brain. Rapid kinetics of incorporation of CNPs into oligodendrocyte plasma membrane in the intact brain are consistent with their synthesis on free polysomes. This hypothesis was confirmed by the translation in vitro of RNA isolated from free and bound polysomes, respectively. Unlike myelin basic protein (MBP) mRNAs, CNP mRNAs are not enriched in a myelin\u2010associated pool of RNA. MBPs, but not CNPs, were found to readily associate in vitro with membrane vesicles derived from rough endoplasmic reticulum. The avidity of MBPs in binding to membranes is probably related to the previously observed spatial segregation of MBP mRNAs into actively myelinating cellular processes of the oligodendrocyte. Such a segregation would ensure that newly synthesized MBPs are immediately incorporated into myelin. In contrast, the CNPs probably associate with the cytoplasmic surface of the oligodendrocyte plasma membrane through interaction with a membrane\u2010bound receptor.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39670535,"openaccessinfo":{"externalids":{"MAG":"1999164770","ACL":null,"DOI":"10.1111\/j.1471-4159.1990.tb01921.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Biodiesel has become an important renewable fuel, especially with the high price of petroleum and growing concern for the environment. This article analyses the impact of the rise in biodiesel demand on the price of Malaysian palm oil. The demand for biodiesel would reduce the volume of palm oil available in the market, putting upward pressure on its price and those of other vegetable oils. With this recent new demand, the palm oil price has increased sharply since July 2006, which can be taken as the date when the palm oil price began to be influenced by the traditional economic factors, such as its production, price of soyabean oil, stock-usage ratio and weather, as well as by the new demand for biodiesel. The autoregressive integrated moving average (ARIMA) method was used to estimate the palm oil price from July 2006 to end 2007 without the effect of biodiesel. This showed a rising trend \u2013 as with biodiesel included but much less steep than with the effect of biodiesel included. This result was confirmed by the time-varying parameters model used to compensate for the ARIMA results. Using the model and considering all the factors, including biodiesel demand, the palm oil price is forecast to remain high, averaging RM 3500\/t for 2008.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":195061169,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The general ASIC (application-specific integrated circuit) design flow is discussed. Critical management milestones in the flow requiring judgement, action, or decisions are isolated and discussed. Key prerequisites that should be addressed as the designer moves from step to step in the flow are also discussed. The ASIC design process has a well established flow that is easily understood and managed. The techniques discussed can be adapted to most companies. Some companies will emphasize certain management milestones over others, depending on how many devices they have designed, the complexity of the devices they are attempting to design, the organization under which the CAE (computer-aided engineering) will be accessed and operated, and the relationship with the ASIC vendor.<>","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":29489569,"openaccessinfo":{"externalids":{"MAG":"2139573547","ACL":null,"DOI":"10.1109\/TEST.1988.207848","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Initial reports of blood T cell subsets in insulin-dependent (type I) diabetes mellitus (IDDM) are conflicting and, consequently, difficult to relate to animal models of the disease. To minimize technical artefacts, which may have contributed to previous results, we used direct immunofluorescence on whole blood and counted 3,000 lymphocytes by flow cytometer. Forty-two IDDM patients divided in three groups of 14 according to the disease duration and 12 age and sex matched controls were studied for T3, T4, T8 and HLA-DR expression. No statistically significant differences were found in their total blood lymphocyte counts or in the percentage of T3, T4 and T8 positive cells, although mild lymphopenia was found in the group of long-standing diabetics. The percentage of activated T cells, identified as T3+\/DR+ cells, was significantly increased in the groups of patients studied more than a month after diagnosis and in four of 14 patients studied within a month from diagnosis. Seven new onset IDDM patients were studied for co-expression of T8 and Leu 15 antigens (putative suppressor cell phenotype), but no significant differences was found compared with controls. We conclude that T4\/T8 ratio abnormalities previously reported in Ficoll separated cells are not reproduced when unseparated cells are analysed by flow cytometry, although the presence of HLA-DR+ T cells is confirmed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8815921,"openaccessinfo":{"externalids":{"MAG":"24406010","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper argues that the death of Elder Citizen Michael Igiebor Okhokpa represents a \nmanifestation of human dignity abuse in Africa. It calls for a theological response against the dehumanizing circumstances and \ncontexts surrounding his death. Humiliating and maltreating persons created in the image of God, people who expended a better \npart of their gifts of life serving God through serving humanity, is unacceptable. The circumstances leading to Michael's death \n are summarized, while its theological implications are outlined as: public theological response; public theology as prophetic \n discourse; advocacy as a theological response; conscientization as a theological response to public opinion (re)formation; and \n status confessionis \/ processus confessionis as good news to the wounded hearts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":147304055,"openaccessinfo":{"externalids":{"MAG":"2281361312","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Feather-pecking behavior in laying hens (Callus gallus) may be considered a behavioral pathology, comparable to human psychopathological disorders. Scientific knowledge on the causation of such disorders strongly suggests involvement of the serotonergic (5-hydroxytryptamine; 5-HT) system in feather pecking. Previously, chicks from a high-feather-pecking (HFP) line were found to display lower 5-HT turnover levels than chicks from a low-feather-pecking (LFP) line (in response to acute stress; Y. M. van Hierden et al., 2002). The present study investigated whether low 5-HT neurotransmission modulates feather pecking. First. S-15535, a somatodendritic 5-HT-sub(1A) autoreceptor agonist, was demonstrated to be an excellent tool for reducing 5-HT turnover in the forebrain of LFP and HFP chicks. Second, the most effective dose of S-15535 (4.0 mg\/kg body weight) significantly increased severe feather-pecking behavior. The results confirmed the postulation that the performance of feather pecking is triggered by low 5-HT neurotransmission.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28645912,"openaccessinfo":{"externalids":{"MAG":"2026477114","ACL":null,"DOI":"10.1037\/0735-7044.118.3.575","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"1 Following denervation of the human parotid salivary gland, pilocarpine caused an intensified stimulant response on salivation and a stimulant effect of atropine on salivary secretion was revealed. However, despite its stimulant effect on salivary secretion, atropine retained its action in blocking the salivatory response to pilocarpine. 2 This dualism in the action of atropine is explained by an action on different muscarinic receptor sub-types, i.e. on some sub-types atropine behaves as an antagonist and on others as an agonist. 3 Under the particular conditions in which the studies were performed, pilocarpine neither prevented nor increased the subsequent paradoxical response to atropine. Moreover, when injected at the peak of the atropine salivatory response it caused neither addition nor synergism to the atropine response. 4 Following the simultaneous injection of both pilocarpine and atropine, atropine initially suppressed the effect of pilocarpine and then itself caused a powerful paradoxical salivation. 5 Pilocarpine injected at the end of the paradoxical secretory response to atropine caused no secretion indicating that atropine retained its antisecretory effect against pilocarpine. 6 The extent of pilocarpine secretory responses is dependent upon the presence or absence of atropine, whilst the atropine effect is independent of the presence of pilocarpine. This points to the presence of differing populations of cholinoreceptors to explain the agonist effects of pilocarpine and atropine.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42446652,"openaccessinfo":{"externalids":{"MAG":"1991309913","ACL":null,"DOI":"10.1111\/J.1474-8673.1987.TB00151.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Linear spectral mixture analysis (LSMA) is a theory that can be used to perform spectral unmixing where three major LSMA techniques, least squares orthogonal subspace projection (LSOSP), non-negativity constrained least squares (NCLS) and fully constrained least squares (FCLS) have been developed for this purpose. Subsequently, these three techniques were further extended to Fisher's LSMA (FLSMA), weighted abundance constrained LSMA (WAC-LSMA) and kernel-based LSMA (K-LSMA). This paper combines both approaches of KLSMA and WAC-LSMA to derive a most general version of LSMA, kernel-based WACLSMA (KWAC-LSMA), which includes all the above-mentioned LSMA as its special cases. In particular, a new version of kernelizing FLSMA, referred to as kernel FLSMA (K-FLSMA) can be also developed to enhance the FLSMA performance by replacing the weighting matrix used in WAC-LSMA with a matrix specified by the within-class scatter matrix. The utility of the KWAC-LSMA is further demonstrated by multispectral and hyperspectral experiments for performance analysis.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":22521391,"openaccessinfo":{"externalids":{"MAG":"2090589577","ACL":null,"DOI":"10.1109\/JSTARS.2012.2234441","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper on topological spaces we formulate new monotone principles of fixed point, forked point and fixed apex. This text continues the further study of the paper by M. R. T a s k o v i \u0107 [A monotone principle of fixed points, Proc. Amer. Math. Soc., 94 (1985), 427-432, Lemma 2 and Theorem 2]. New monotone principles to include some recent results of author, which contains, as special cases, some results of S. Banach, J. Dugundji and A. Granas, F. Browder, D. W. Boyd and J. S. Wong, J. Caristi, T. L. Hicks and B. E. Rhoades, B. Fisher, S. Massa, \u00d0. Kurepa, M. Kwapisz, W. Kirk, S. Park, M. Krasnoselskij, V. J. Ste\u010denko, T. Kiventidis, I. Rus, K. Is\u00e9ki, J. Walter, J. Dane\u0161, A. Meir and E. Keeler, L. Collatz, J. Istr\u01ce\u0163escu, A. Miczko, and B. Palczewski, C. S. Wong, and many others.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":126225670,"openaccessinfo":{"externalids":{"MAG":"2794207985","ACL":null,"DOI":"10.5937\/MATMOR1002019T","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Policy based management and process based management are two main management paradigms that are widely used in modern information management systems. To integrate the two paradigms and take the advantages from both, a conceptual framework is presented in this paper. Some key issues to implement the framework are addressed: during build time, policy definitions, translation and mapping among policies and sub-processes, and policy conflict detection and resolution; at run-time, interaction between policy server and workflow engine, policy-enabled component, and policy deployment. A simple example of resource policy is provided","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":15017043,"openaccessinfo":{"externalids":{"MAG":"1976327330","ACL":null,"DOI":"10.1109\/CSCWD.2006.253052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Over the past few decades the Arctic has warmed up more than the lower latitudes. Soil organic carbon (SOC) in the Arctic is vulnerable to climate change, and carbon dioxide (CO2) produced via SOC decomposition can amplify atmospheric temperature increase. Although SOC composition is relevant to decomposability, studies on its compositional changes with warming are scarce, particularly in the Arctic. Therefore, we investigated the responses of SOC and the bacterial community to climate manipulation under Cassiope and Salix heath vegetation communities in permafrost\u2010affected soil in Zackenberg, Greenland. After 8\u20139\u2009years of experimental warming, we evaluated changes in SOC quantity and quality of three density fractions of soil: free light fraction (FLF), occluded light fraction (OLF) and heavy fraction (HF). The SOC content at 0\u20135\u2010cm depth was significantly reduced with warming under Cassiope, and it was accompanied by decreased FLF content, attributed to accelerated decomposition of the FLF by warming. However, SOC molecular composition and bacterial community composition were not affected by warming. By contrast, there was no warming effect on SOC under Salix, which could be partially due to smaller temperature increases caused by higher moisture levels associated with larger silt and clay contents, or to different responses of the dominant plant species to temperature. In both soils, more than 55% of SOC was associated with minerals, and its molecular composition indicated microbial decomposition. Our results suggested that long\u2010term warming in the high Arctic could induce the loss of SOC, particularly in the FLF; however, the response could vary with vegetation type and\/or soil properties, that is, soil texture.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":208737709,"openaccessinfo":{"externalids":{"MAG":"2977370791","ACL":null,"DOI":"10.1111\/ejss.12896","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: This review addressed the focused question of what is the predictability of vertical ridge augmentation techniques for patients, who were diagnosed with insufficient alveolar bone volume for the placement of dental implants. Material and Methods: A systematic online review of three main databases was performed between 1966 and 1 November 2007. Four groups of vertical bone augmentation techniques have been identified and evaluated: (1) guided bone regeneration, (2) distraction osteogenesis, (3) onlay bone grafting, and (4) an array of different techniques. Data extraction was based on the following outcomes: (a) success and failure rate of the procedure (vertical bone gain\/loss), (b) complication rate of the procedure, and (c) implant survival, success and failure rate. Results: The initial search identified 189 papers from the electronic database. The review produced seven papers for GBR, 13 reporting distraction osteogenesis, five for onlay bone grafting and three describing different techniques. Conclusions: For the concept of vertical ridge augmentation to enable dental implant placement, there are clinical and histological data supporting its potential use. Given the confined number of investigators using these techniques and the low number of patient treatments reported in the literature, the generalizability of this approach is limited at this time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137949768,"openaccessinfo":{"externalids":{"MAG":"2182815147","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A coherent way of interpolating 3-D data obtained by stereo, for example, with a simplicial polyhedral surface is discussed. The method is based on constrained Delaunay triangulation; the polyhedral surface is obtained by using a simple visibility property to mark tetrahedra likely to be empty. The method is intrinsically discontinuity-preserving and yields both a surface representation of objects and a volume representation of free space which may be useful in robotics. Algorithms to implement the method are described and their complexity analyzed in the worst case and average case situations where tools of probabilistic geometry are used.<>","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-06":1}},"corpusid":33292472,"openaccessinfo":{"externalids":{"MAG":"2106350541","ACL":null,"DOI":"10.1109\/ROBOT.1988.12326","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Wireless communication at the terahertz (THz) frequency bands (0.1\u201310 THz) is viewed as one of the cornerstones of tomorrow's 6G wireless systems. Owing to the large amount of available bandwidth, if properly deployed, THz frequencies can potentially provide significant wireless capacity performance gains and enable high-resolution environment sensing. However, operating a wireless system at high-frequency bands such as THz is limited by a highly uncertain and dynamic channel. Effectively, these channel limitations lead to unreliable intermittent links as a result of an inherently short communication range, and a high susceptibility to blockage and molecular absorption. Consequently, such impediments could disrupt the THz band's promise of high-rate communications and high-resolution sensing capabilities. In this context, this paper panoramically examines the steps needed to efficiently and reliably deploy and operate next-generation THz wireless systems that will synergistically support a fellowship of communication and sensing services. For this purpose, we first set the stage by describing the fundamentals of the THz frequency band. Based on these fundamentals, we characterize and comprehensively investigate seven unique defining features of THz wireless systems: 1) Quasi-opticality of the band, 2) THz-tailored wireless architectures, 3) Synergy with lower frequency bands, 4) Joint sensing and communication systems, 5) PHY-layer procedures, 6) Spectrum access techniques, and 7) Real-time network optimization. These seven defining features allow us to shed light on how to re-engineer wireless systems as we know them today so as to make them ready to support THz bands and their unique environments. On the one hand, THz systems benefit from their quasi-opticality and can turn every communication challenge into a sensing opportunity, thus contributing to a new generation of versatile wireless systems that can perform multiple functions beyond basic communications. On the other hand, THz systems can capitalize on the role of intelligent surfaces, lower frequency bands, and machine learning (ML) tools to guarantee a robust system performance. We conclude our exposition by presenting the key THz 6G use cases along with their associated major challenges and open problems. Ultimately, the goal of this article is to chart a forward-looking roadmap that exposes the necessary solutions and milestones for enabling THz frequencies to realize their potential as a game changer for next-generation wireless systems.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":231925099,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/comst.2022.3143454","PubMedCentral":null,"ArXiv":"2102.07668"},"license":null,"url":"https:\/\/vbn.aau.dk\/files\/518923077\/nbnfi_fe2022090257043.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper presents the development, validation, and application of new approximate (semi-analytical) solutions for the wellbore pressure and fractional flowrate responses of commingled layered reservoirs \u2014 without interlayer crossflow (crossflow is only permitted in the wellbore, not in the reservoir). These formulations use \"basis\" pressure drop relations for each layer as a mechanism to create multilayer solutions in the Laplace domain \u2014 and due to the choice of these basis relations; the formulation can be analytically inverted into the real domain. This process provides a direct (albeit approximate) solution for multilayer reservoir systems. The basis relations include a \"constant\" pressure case and \"linear\" pressure case. In addition to these methods, we also provide a \"Total Pressure\/Rate Averaging\" (TPRA) formulation which is used to provide an average rate and pressure response for each layer. These semi-analytical solutions can be used to construct well test or production profiles in a simple computational environment (e.g., a spreadsheet). These solutions can also be used to diagnose well test and production data in terms of layered reservoir behavior. The \"linear\" pressure case (non-zero intercept) gives the best performance \u2014 however, from a practical standpoint, the algebra involved limits this approach to 2-layer reservoir case. The TPRA formulation is very consistent, but not as accurate as the other solutions \u2014 however; the TPRA formulation is easily be extended to n-layers. Objectives The primary objectives of this work are: \uf06c To develop approximate (semi-analytical) solutions for the wellbore pressure and fractional flowrate responses of commingled layered reservoirs\u2013\u2013without interlayer crossflow (crossflow is only permitted in the wellbore, not in the reservoir). \uf06c To apply these new solutions for the analysis\/modeling of well performance behavior in multilayer reservoir systems. Introduction We begin with a brief discussion of the concepts of pressure transients and differential depletion which exist in the multilayer reservoirs. We consider a layered reservoir to be a geologic formation that consists of horizontally continuous, homogeneous, and isotropic layers which differ markedly in permeability and porosity, but not necessarily in gross lithologic features. Thus, a reservoir that is lithogically homogeneous on a macroscopic scale is considered layered if it could be divided into laterally continuous layers of differing permeabilities and porosities. For the purpose of this study, a layered reservoir system is defined as a reservoir that is composed of two or more layers of differing physical characteristics, such as permeability, porosity, thickness, outer radius, and skin. The term \"layer\" is defined as a reservoir body that has a particular combination of permeability and porosity which allows fluid to flow. Each layer could be separated by impermeable barriers where no interlayer crossflow occurs \u2013\u2013 this is also known as a commingled reservoir, where crossflow is only permitted in the wellbore (not in the reservoir). Fig. 1 shows a schematic of an actual multilayer reservoir system which consists of a sand and shale sequence [Gringarten et al (1981)]. Fig. 2 illustrates the schematic multilayer reservoir model used in this study. The reservoir consists of two or more layers with different physical characteristics such as permeability, thickness, porosity, skin, and outer radius. These layers are unconnected except at the well. Each layer of the reservoir is assumed to be homogeneous and isotropic, and is filled with a fluid of small and constant compressibility. The reservoir is initially at a uniform pressure and at all times is produced in such a manner that the total production rate measured at initial reservoir conditions is held constant. Gravity and capillary pressure effects are assumed to be insignificant. (Revision: 15 June 2008) 2 E.P. Lolon, R.A. Archer, D. Ilk, and T.A. Blasingame SPE 114946 Figure 1\u2014 Schematic of an actual multilayer reservoir system. k3, h3, \uf0663, s3, re3 k1, h1, \uf0661, s1, re1 k2, h2, \uf0662, s2, re2","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":15612131,"openaccessinfo":{"externalids":{"MAG":"2015352846","ACL":null,"DOI":"10.2118\/114946-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A wireless sensor network can be divided into several clusters. Each cluster has a number of sensors nodes and one of the nodes is elected as the coordinator. The coordinator is responsible for not only the general mission but also collecting the sensed data of other nodes and routing to the sink. Accordingly, the energy-consumption is higher than other nodes. Therefore, the coordinator selection methods will affect the life-time of a network. Besides, the conventional coordinator selection method cannot be available to different requests of sensor networks. In this study, we divided the missions into two types. One is that a mission can be performed by most of the sensor nodes. The other is that a mission can be performed by just few of the sensor nodes. Accordingly, we give different selection methods to suitable the requests. Simulation results demonstrate our study can enlarge the life time for different requests of the sensor networks.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":22854998,"openaccessinfo":{"externalids":{"MAG":"2119379195","ACL":null,"DOI":"10.1109\/NCM.2009.279","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Eco-friendly waste utilization helps in the development of sustainable infrastructures. Recently, researchers have focused on the production of road infrastructures using the circular economy concept of human safety. The objective of this study is to investigate and explore the utilization of optimum polymer waste content for the development of polymer-modified asphalt mixtures using response surface methodology (RSM). RSM based on Box\u2013Behnken design (BBD) was employed to optimize experimental design and included three factors: X1, polymer type; X2, polymer contents; and X3, testing day. The optimized responses determined by the RSM were as follows: MS of 42.98 kN, MF of 5.08 mm, and MQ of 8.66 kN\/mm, indicating a favorable and consistent precision in comparison with experimental values. Moreover, the Marshall characteristics of samples prepared with PE were quite improved compared to PET. In conclusion, the incorporation of such polymer wastes in road construction is a sustainable and cost-effective way of improving their engineering properties. This study will help in the development of sustainable road infrastructures supporting human safety and environmentally friendly practices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249908741,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/polym14122493","PubMedCentral":"9228266","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-4360\/14\/12\/2493\/pdf?version=1655804125","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose: To inform healthcare providers about waterpipe smoking, a new trend in tobacco use that is gaining popularity among adolescents and young adults. Data sources: American Lung Association Tobacco Policy Alert on Waterpipe Smoking, World Health Organization Tobacco Regulation Advisory Note on Waterpipe Smoking, and pertinent publications available in the literature. Conclusions: Waterpipe smoking is a new trend in tobacco use that is associated with multiple health problems, including addiction. Healthcare providers should be aware of new tobacco trends that may affect patients, such as waterpipe smoking, that are potential gateways to nicotine addiction. Implications for practice: Tobacco comes in many forms, all of which are addicting. Healthcare providers must be knowledgeable about new forms of tobacco to address all types of tobacco use with patients. Healthcare providers also have a responsibility to educate patients about the health risks inherent in these products to help prevent the long\u2010lasting problem of nicotine addiction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34616496,"openaccessinfo":{"externalids":{"MAG":"2092801667","ACL":null,"DOI":"10.1111\/j.1745-7599.2009.00402.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Dysfunction of spinal inhibitory neurotrans- mission is a major pathogenetic factor in the development of neuropathic pain. Restoration of effective inhibition hence represents a promising thera- peutic strategy. Glycine is, beside GABA, the major inhibitory neurotransmit-ter in the CNS. Its concentration in the synaptic cleft is controlled by the two glycine transporters GlyT1 and GlyT2. Inhibitors of both transporters act anti-nociceptive in various animal pain models, when applied as bolus [1]. Yet, in some studies, serious neuromotor side effects were reported [2]. Aim of the present study was to elucidate whether continuous inhibition of the respective GlyT can ameliorate neuropathic pain without significant Finding new drugs to alleviate neuropathic pain is indispens- able but getting new molecules through the funnel of clinical trial is an ardu-ous process. We therefore choose to test the potential of rufinamide (RUF), a Na channel blocker anticonvulsant licensed for treatment of Lennox-Gastaud syndrome (a severe form of epilepsy resistant to conventional therapy). Dys- regulation of voltage-gated Na channels (Nav1.x) is a central feature of pain hyperexcitability. Nav1.7 isoform is essential to pain perception since muta- tions in its gene are associated to either inherited pain syndromes or insensi-tivity to pain. In the present study, we compared the effect of RUF to amitrip- tyline (AMI, currently used to treat chronic pain) on a model of neuropathic pain and on Nav1.7 channel Methods: We used the SNI 10\/group). One A 20mg\/kg) allodynia von Frey filaments for 1 day. were on na\u00efve Whole-cell patch clamp was performed to test RUF and AMI on Nav1.7 expressed in HEK293 however a shift in the steady-state inactivation curve was observed (-5.76mV for RUF and -9.56mV for AMI, p< 0.005). Use dependent block was observed at 5, 10, 25 and 50Hz (p< 0.05). RUF and AMI modulate Nav1.7 in vitro and demonstrated efficacy in alleviat-ing neuropathic in an animal model. At equipotent doses on SNI induced allo- dynia, AMI showed alteration in behavioral response in na\u00efve animals possibly due to either alteration of basal pain sensitivity or a sedative effect. Conclusion: Side effect is a major problem with drugs such as AMI. RUF shows a better tolerability in an experimental pain model. Taken together our results suggest RUF could be a new alternative for the treatment of neuropathic Background and Goal of Study: Pain relief after surgical procedures con- tinues to be a major medical challenge. The recognition that unrelieved pain contributes to postoperative morbidity and mortality has inspired many insti- tutions to develop an Acute Pain Service (APS) in an attempt to provide safe and effective postoperative relief. The goal of the study is to assess the impact of postoperative pain management provided by a nurse based-anaesthesiolo-gist supervised APS on quality of care and costs. Materials and Methods: Conclusion(s): The identification of","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264587689,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the complex metallic alloys (CMA) it is often found that some parts of the unit cell form well-defined nanoscale building blocks, called clusters, which are characterized by a specific local symmetry and separated from the 'matrix' crystal lattice by a partially disordered interface zone. The interior of the cluster is usually a close packed structure, the structure of which is not always exactly known, because of the partial disorder in the outer coordination shells. In many CMA's the clusters form a high-symmetry superlattice structure, what usually leads to a giant cubic or pseudo cubic unit cell. The present paper shows a possibility to analyze the changes in local symmetry of the clusters (objects decorating the superlattice nodes) during transformations of the global crystal symmetry. The symmetry analysis method applied to tensor objects, attributed to the clusters, provides information about the symmetry relations between the objects located in different nodes as well as the local symmetry of individual objects (local principal axes, local anisotropy etc.)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250674736,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1742-6596\/104\/1\/012023","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/104\/1\/012023\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"For ABR multicast 1 (point-to-multipoint) ow, ATM Forum 9] proposes to have fusion of feedbacks, coming from multiple destinations of the connection, at branch-points. For that matter, many fusion algorithms are proposed in the past for multicast ABR applications 3, 2, 4, 1]. In the conception of these fusion algorithms, the possible sharing of bandwidth by a n y unicast ABR ow on the same link has not been taken into account which m a k es that the fusion algorithms lack i n m a i n taining a service balance between unicast and multicast ABR ows and eventually the optimal utilization of available bandwidth is not attained. We solve these problems by employing, at switches, an arbitration algorithm, that observes the rate at which queues, for unicast as well as for multicast connections at an output port, are served and accordingly assigns them certain priority levels. The results show that the service balance is maintained between unicast and multicast queues in accordance to their fair share and the utilization of link available bandwidth is improved .","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264167072,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Core-shell nanoparticles composed of ferromagnetic cobalt platinum cores covered by non-magnetic silica shells were synthesized by laser ablating a composite target in a helium background gas. The average diameter of the CoPt core was controlled by adjusting the CoPt\/SiO2 ratio of the ablation target. The particles were also classified in the gas phase using an electrical mobility classifier. The present method successfully synthesized nearly monodispersed nanoparticles with an average core diameter of 2.5nm. This article describes the synthesis of the core-shell nanoparticles and investigates their magnetic properties.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250681197,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1742-6596\/59\/1\/054","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/59\/1\/054\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective: This study investigated effects of S-allylmercaptocysteine (SAMC), diallyl disulfide (DADS), and vitamin B12 on inner ear functions and morphology after long-period high-level broadband noise exposure. Materials and Methods: Twenty-four healthy rats were randomly divided into four groups. First group was chosen as the control group. Vitamin B12, SAMC, and DADS were applied to other groups for 4 weeks. On the 14th day, each group was exposed to broadband noise. Auditory brainstem response test was performed before and immediately after noise exposure and repeated on the 2nd and 14th day. Results: Permanent threshold shifts were significantly lower in groups treated with vitamin B12, SAMC, and DADS. Histologically, cochleae of SAMC and DADS groups were found to be better preserved than the cochleae of vitamin B12 and control groups. Conclusion: Physiologically and histologically, SAMC and DADS reduced the long-term effects of noise. However, physiological recovery was not consistent with the morphological findings in vitamin B12 group.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":209317608,"openaccessinfo":{"externalids":{"MAG":"2995999172","ACL":null,"DOI":"10.4103\/nah.NAH_33_18","PubMedCentral":"6924192","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to determine whether there is a strong relationship between . reading attitlldes and achievement of adult male inmates and what motivates them to want to learn to read. Eighty (80) inmates enrolled in the Pre-GED classes at a medium security prison in western New York were given a . reading attitude inventory designed by the researcher based on the Estes Reading Attitude Scale. Reading scores for each student were also gathered from the TABE test. The relationship of the attitude inventory and achievement was then analyzed. It was found that in this study, reading attitude was a poor predictor for achievement. Five inmates were then randomly selected from those who scored high on the TABE tests and five from those who scored lowest. These inmates were asked a series of motivation questions which were recorded by the researcher. It was found that in the inmates' view, learning to read was important in everyday living, especially in getting a job and obtaining\u00b7 a high school diploma.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":150067968,"openaccessinfo":{"externalids":{"MAG":"2802704539","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Crystallite refers to a single crystalline grain in crystal aggregates, and multiple crystallites form a grain boundary or the inter-crystallite interface1. A grain boundary is a structural defect that hinders the efficient directional transfer of mechanical stress or thermal phonons in crystal aggregates. We observed that grain boundaries within anaggregate of a-few-nanometers-wide fibrillar crystallites of cellulose were crystallized by enhancing their inter-crystallite interactions; multiple crystallites were coupled into single fusion crystals without passing through a melting or dissolving state. Accordingly, the crystallinity of naturally occurring cellulose, which has previously been considered irreversible once decreased2, was recovered, and the thermal energy transfer in the aggregate was significantly improved. Other fibrillar crystallites of chitin also showed a similar fusion phenomenon by enhancing the inter-crystallite interactions. Crystallite fusion in aggregates may occur for other biopolymers.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":236349889,"openaccessinfo":{"externalids":{"MAG":"3161255632","ACL":null,"DOI":"10.21203\/RS.3.RS-518217\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Effective second language medium of instruction refers to an instructional approach that differs from that of regular, first language content instruction or a language across the curriculum approach. This approach uses language teaching strategies in subjects other than the formal language classes, to promote both conceptual and language development in language learners. The purpose of this article is to suggest a scheme for training effective second language medium of instruction teachers in the South African context. In order to determine how teachers should be trained (both on in-service and pre-service level), the article proposes a profile of what can be construed as effective English second language medium of instruction (L2MI). It is then used as a template for identifying outcomes that need to be attained by L2MI teachers and for the design of a checklist that may be used for teacher training at inservice or pre-service level. Keywords : English medium of instruction; language across the curriculum; teacher training Journal for Language Teaching Vol. 39(2) 2005: 321-335","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":62726980,"openaccessinfo":{"externalids":{"MAG":"2058140800","ACL":null,"DOI":"10.4314\/JLT.V39I2.6065","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Inertial Confinement Fusion (ICF) research has historically been a driver in the development of high performance, high damage threshold optical coatings. This is particularly the case now as the ICF community develops plans for a proposed 1.8 mega-joule solid state (Nd+3-phosphate glass) laser system. The new system, the National Ignition Facility, is possible in part due to advances in optical coatings technology including the laser-conditioning of multilayer dielectrics and broadened applications for room-temperature deposited coatings. Sol-gel AR coatings are the standard for large, high-power laser optics and sol-gel HR coatings are being developed. For mirror and polarizer coatings, e-beam-deposited dielectrics continue to provide the highest damage threshold coatings, but their laser damage thresholds and optical performance are limited by micrometers -scale defects and poor control over layer thickness, respectively. More energetic deposition techniques such as IAD and IBS, now popular in the commercial market, offer both advantages and disadvantages in this high-damage- threshold coatings market.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":135750699,"openaccessinfo":{"externalids":{"MAG":"2057193343","ACL":null,"DOI":"10.1117\/12.185807","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/digital.library.unt.edu\/ark:\/67531\/metadc1402001\/m2\/1\/high_res_d\/10181248.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Multi-targeting antibiotics, i.e. single compounds capable to inhibit two or more bacterial targets offer a promising therapeutic strategy, but information on resistance evolution against such drugs is scarce. Gepotidacin is an antibiotic candidate that selectively inhibits both bacterial DNA gyrase and topoisomerase IV. In a susceptible organism, Klebsiella pneumoniae, a combination of two specific mutations in these target proteins provide an over 2000-fold increment in resistance, while individually none of these mutations affect resistance significantly. Alarmingly, gepotidacin-resistant strains are found to be as virulent as the wild-type K. pneumoniae strain in a murine model, and extensive cross-resistance was demonstrated between gepotidacin and ciprofloxacin, a fluoroquinolone antibiotic widely employed in clinical practice. This suggests that numerous fluoroquinolone-resistant pathogenic isolates carry mutations which would promote the evolution of clinically significant resistance against gepotidacin in the future. We conclude that prolonged antibiotic usage could select for mutations that serve as stepping-stones towards resistance against antimicrobial compounds still under development. More generally, our research indicates that even balanced multi-targeting antibiotics are prone to resistance evolution.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":92486991,"openaccessinfo":{"externalids":{"MAG":"2904823130","ACL":null,"DOI":"10.1101\/495630","PubMedCentral":null,"ArXiv":null},"license":"CCBYND","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2018\/12\/13\/495630.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"What is the best way to improve access and learning outcomes for girls? This review brings together evidence from 267 educational interventions in 54 low- and middle-income countries \u2013 regardless of whether the interventions specifically target girls \u2013 and identifies their impacts on girls. To improve access and learning, general interventions deliver average gains for girls that are comparable to girl-targeted interventions. General interventions have similar impacts for girls as for boys. Taken together, these findings suggest that many educational gains for girls may be achieved through nontargeted programs. Many of the most effective interventions to improve access for girls relax household-level constraints (such as cash transfer programs), and many of the most effective interventions to improve learning for girls involve improving the pedagogy of teachers. Girl-targeted interventions may make the most sense when addressing constraints that are unique to, or most pronounced for, girls.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":243331555,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/wber\/lhab007","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/academic.oup.com\/wber\/article-pdf\/36\/1\/244\/42803867\/lhab007.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Plasma immersion ion implantation (PIII) of a dielectric object is not straightforward to simulate because the surface will be charged during the process. The one-dimensional analytic equation developed by Emmert [J. Vac. Sci. Technol. B Microelectron. Process. Phenom., vol. 12, pp. 880, 1994] cannot be applied to a two-three-dimensional dielectric object. In this paper, the author develops a numerical model that can handle the surface charging effect of a complex dielectric object. The model is used to simulate the metal PIII and deposition of a dielectric wedge. The potential of the internal volume of the wedge is solved by Laplace's equation, the boundary between the wedge and metal plasma is handled by Gauss' law, and the bulk metal plasma region is simulated by the hybrid model of particle-in-cell ions and Boltzmann distribution of electrons. It shows that the equilibrium steady-state ion sheath formed by the sample stage biased at -8 kV is modified by the thinner dielectric wedge with the height of 0.03 m. The tip of the dielectric wedge is touched by the main stream of the metal plasma","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":35557965,"openaccessinfo":{"externalids":{"MAG":"2161411027","ACL":null,"DOI":"10.1109\/TPS.2006.878432","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is widely accepted that most natural language expressions do not have precise universally agreed definitions that fix their meanings. Except in the case of certain technical terminology, humans use terms \nin a variety of ways that are adapted to different contexts and perspectives. Hence, even when conversation participants share the same vocabulary and agree on fundamental taxonomic relationships (such as subsumption and mutual exclusivity), their view on the specific meaning of terms may differ significantly. Moreover, even individuals themselves may not hold permanent points of view, but rather adopt different semantics depending on the particular features of the situation and what they wish to communicate. \n \nIn this thesis, we analyse logical and representational aspects of the semantic variability of natural language terms. In particular, we aim to provide a formal language adequate for reasoning in settings where different agents may adopt particular standpoints or perspectives, thereby narrowing the semantic variability of the vague language predicates in different ways. \n \nFor that purpose, we present standpoint logic, a framework for interpreting languages in the presence of semantic variability. We build on supervaluationist accounts of vagueness, which explain linguistic indeterminacy in terms of a collection of possible interpretations of the terms of the language (precisifications). \nThis is extended by adding the notion of standpoint, which intuitively corresponds to a particular point of view on how to interpret vague terminology, and may be taken by a person or institution in a relevant context. A standpoint is modelled by sets of precisifications compatible with that point of view and does not need to be fully precise. \nIn this way, standpoint logic allows one to articulate finely grained and structured stipulations of the varieties of interpretation that can be given to a vague concept or a set of related concepts and also provides means to express relationships between different systems of interpretation. \n \nAfter the specification of precisifications and standpoints and the consideration of the relevant notions of truth and validity, a multi-modal logic language for describing standpoints is presented. The language includes a modal operator for each standpoint, such that $\\standb{s}\\phi$ means that a proposition $\\phi$ is unequivocally true according to the standpoint $s$ --- i.e.\\ $\\phi$ is true at all precisifications compatible with $s$. \nWe provide the logic with a Kripke semantics and examine the characteristics of its intended models. \nFurthermore, we prove the soundness, completeness and decidability of standpoint logic with an underlying propositional language, and show that the satisfiability problem is NP-complete. \nWe subsequently illustrate how this language can be used to represent logical properties and connections between alternative partial models of a domain and different accounts of the semantics of terms. \n \nAs proof of concept, we explore the application of our formal framework to the domain of forestry, and in particular, we focus on the semantic variability of `forest'. In this scenario, the problematic arising of the assignation of different meanings has been repeatedly reported in the literature, and it is especially relevant in the context of the unprecedented scale of publicly available geographic data, where information and databases, even when ostensibly linked to ontologies, may present substantial semantic variation, which obstructs interoperability and confounds knowledge exchange.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":228132906,"openaccessinfo":{"externalids":{"MAG":"3032884960","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The oxygen surface kinetics of Sr 2 Fe 1.5 Mo 0.5 O 6\u2212\u03b4 was determined using the 16 O 2 \/ 18 O 2 isotope exchange method with gas phase analysis at 600\u2013800 \u00b0C. The heterogeneous exchange rates ( r H ) and the oxygen diffusion coefficients ( D ) were calculated by processing the concentration dependences of the 18 O fraction using Ezin's model. The rates of oxygen dissociative adsorption ( r a ) and incorporation ( r i ) were calculated based on a model using the three exchange type rates. It has been established that the rates r a and r i were comparable in this temperature range. Assumptions were made about the effect of the chemical composition of the surface on the rate of oxygen adsorption. It was found that the oxygen exchange coefficient ( k ) of Sr 2 Fe 1.5 Mo 0.5 O 6\u2212\u03b4 is comparable to that of La 0.6 Sr 0.4 MnO 3\u00b1\u03b4 oxide. High values of the oxygen diffusion coefficient were found for Sr 2 Fe 1.5 Mo 0.5 O 6\u2212\u03b4 . The values were comparable to those of the double cobaltite praseodymium-barium and exceed by more than an order those of lanthanum-strontium manganite.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212765164,"openaccessinfo":{"externalids":{"MAG":"2997381631","ACL":null,"DOI":"10.3390\/en13010250","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/13\/1\/250\/pdf?version=1578371054","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The prediction of minimum-energy protein structures starting from a sequence of amino acids is a computationally challenging problem even in simplified lattice protein models. A hybrid evolutionary model is designed and tested in the current paper to address this well-known NP-hard problem. Hill-climbing strategies are integrated in the search operators and a meaningful diversification of genetic material occurs during the population evolution. The main features of the proposed algorithm refer to a weak hill-climbing application of uniform crossover and pull-move transformations and the randomization of genetic material based on the fingerprint of the protein conformations. Numerical experiments are performed for several difficult bidimensional instances from lattice models (the hydrophobic-polar model and functional model proteins). The results are competitive with those obtained by related population-based optimization algorithms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":20595925,"openaccessinfo":{"externalids":{"MAG":"2168843981","ACL":null,"DOI":"10.1109\/CEC.2011.5949901","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this thesis, chapter 1 addresses the introduction to the project. It deals with the energy efficiency and energy savings. Apart from that, the objectives of this project are described as well as the scope of project. Chapter 2 includes the methodology of the project. Chapter 3 introduces the district cooling concept in brief. The theory of airconditioning is presented in chapter 4. All the theories are based on the thermodynamics and heat transfer point of view. In this chapter, the relevant equations that is important for the energy analysis is defined. Chapter 5 and 6 put forward the energy analysis of the plant land 2. In these chapters, the system's energy balance is analysed. Chapter 7 relates the costing analysis of plant 1. This includes the cost analysis to the theoretical design and actual operating modes. The cost for partial and full-storage system is carried out based on the theoretical operating design. Hence, the payback period for partial and full storage system is obtained. Some improvements to the system is analysed in chapter 8. It involves the modification and replacement of certain component. This analysis is followed by the savings gained through the improvements. The discussion, conclusion and recommendation are imparted in chapter 9, 10 and 11 respectively.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":116151116,"openaccessinfo":{"externalids":{"MAG":"2907126236","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For information devices such as hard disk drives, actuators must be controlled quickly and precisely as much as possible. To satisfy these requirements, feedforward input design is very important. For this problem, we have proposed a frequency-shaped final-state control method. This method can obtain a feedforward input that has lower spectrum at desired frequency points so as to reduce residual vibration after positioning. Furthermore, the method has been extended to generate the feedforward input by a polynomial. By using the polynomial, the required memory size can be drastically reduced because it only requires to store the coefficients of polynomial. However, in the frequency-shaped final-state control method by polynomial input, it is not guaranteed that the solution always exist theoretically. In order to solve this problem, final-state control methods in which the feedforward input is generated by both of a polynomial and time-series data are proposed. The effectiveness of the proposed methods are verified by simulation using the plant model of the HDD benchmark problem. The simulation results show that the proposed method outperform the conventional methods.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":52871892,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the topological properties of compact homogeneous manifolds using the natural bundle as a main construction. We show how to calculate the cohomology of a compact homogeneous manifold considered up to a finite covering. The topology of various special classes of compact homogeneous manifolds is also studied.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122590735,"openaccessinfo":{"externalids":{"MAG":"2072292994","ACL":null,"DOI":"10.1070\/IM2007V071N03ABEH002364","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": The article offers an overview of the deontic theory developed by the philosophical school of M \u012b m (cid:1) a \u1e43 s (cid:1) a, which is, and has been since the last centuries BCE, the main source of normative concepts in Sanskrit thought. Thus, the M \u012b m (cid:1) a \u1e43 s (cid:1) a deontics is interesting for any historian of philosophy and constitutes a thought-provoking occasion to rethink deontic concepts, taking advantage of centuries of systematic re fl ections on these topics. Some comparison with notions currently used in Euro-American normative theories and metaethical principles is offered in order to show possible points of contact and deep divergences. In more detail, after an introduction explaining the methodology and aims of our work, we discuss how M \u012b m (cid:1) a \u1e43 s (cid:1) a authors distinguished and de fi ned some fundamental deontic concepts, such as different types of prescriptions and prohibitions. We then discuss how M \u012b m (cid:1) a \u1e43 s (cid:1) a authors approached the problem of con fl icts among commands without jeopardising the validity of the normative text issuing them. In the second part of the article we introduce our formal apparatus, which is construed around the main taxonomic and conceptual distinctions used in the fi rst part. Our formal rendering captures the most important features of the M \u012b m (cid:1) a \u1e43 s (cid:1) a theory and can thus serve as a concise and rigorous presentation of it for scholars working in deontic logic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252068726,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During the last few years geophysical survey has developed considerably in terms of instrumentation and image processing. Together with remote sensing and GIS, it is becoming increasingly, if still slowly, integrated into archaeological investigations in the Mediterranean. This article reviews how, and with what success, geophysical techniques--and, to a lesser extent, geochemical methods, aerial\/satellite remote sensing and GIS--have been applied to Mediterranean (especially Greek) archaeology, bearing in mind the environmental constraints of the region, and the significance, diversity and number of its ancient monuments. The application of all the main techniques of geophysical survey and some geochemical methods to a wide range of archaeological targets carried out over the last 40 years is discussed critically. Current developments in instrumentation and data processing are presented, and the next generation of geophysical work, which will have to meet challenges in relation to the protection and management of cultural resources, is also considered. In view of the need to create a common platform for the preservation of cultural heritage, it is argued that geophysical prospection techniques have to become an inseparable component of the archaeological investigative process.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":162912216,"openaccessinfo":{"externalids":{"MAG":"2156393223","ACL":null,"DOI":"10.1558\/JMEA.V13I1.3","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report a case of unilateral conjunctival ulcer due to Stenotrophomonas maltophilia infection in an immunocompetent individual. A 44-year-old male presented with complaints of pain and yellowish discharge in the right eye for one week. Patient underwent complete ophthalmic evaluation and relevant laboratory investigations. Anterior segment examination revealed localized conjunctival and episcleral congestion with conjunctival ulceration on the bulbar conjunctiva in the right eye. Gram's stain revealed gram-negative bacilli. Culture and sensitivity revealed S. maltophilia and responded well to topical moxifloxacin with systemic co-trimoxazole therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207454645,"openaccessinfo":{"externalids":{"MAG":"2013647802","ACL":null,"DOI":"10.4103\/0301-4738.94056","PubMedCentral":"3339074","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/0301-4738.94056","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Compensating Government Employees for Price Increase Basis, Trends and Forecasts Poonam Gupta Sanjeev Gupta Does the existing policy of dearness allowance (DA) payments compensate government employees for price increase without introducing distortions in the pay structure? Also, by how much wilt the liability of the govern- ment increase by the turn of the century if present trends in DA payments are maintained? In this paper, the recommendations made by various pay commissions and other bodies on DA since its inception are summarised to bring out the underlying rationale. This is followed by a discussion of the present trends in DA payments. Subsequently, forecast of such payments by the Union government as well as different state governments upto the year 2000 are made. Conclusions are drawn in the last section.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":155648490,"openaccessinfo":{"externalids":{"MAG":"2212715659","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"High power experiments, up to 9.2 MW with LHCD and ICRH, have been carried out in the full tungsten tokamak WEST. Quasi non inductive discharges have been achieved allowing to extend the plasma duration to 53 s with stationary conditions in particular with respect to tungsten contamination. Transitions to H mode are observed, and H-modes lasting up to 4 s have been obtained. The increase in stored energy is weak since the power crossing the separatrix is close to the L\u2013H threshold. Hot L mode plasmas (central temperature exceeding 3 keV) with a confinement time following the ITER L96 scaling law are routinely obtained. The weak aspect ratio dependence of this scaling law is confirmed. Tungsten accumulation is generally not an operational issue on WEST. Difficulty of burning through tungsten can prevent the discharge from accessing to a hot core plasma in the ramp-up phase, or can lead to rapid collapse of the central temperature when radiation is enhanced by a slight decrease of the temperature. Except a few pulses post-boronization, the plasma radiation is rather high (P rad\/ P tot \u223c 50%) and is dominated by tungsten. This fraction does not vary as the RF power is ramped up and is quite similar in ICRH and\/or LHCD heated plasmas. An estimate of the contribution of the RF antennas to the plasma contamination in tungsten is given.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":252654333,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1741-4326\/ac9691","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/cea.hal.science\/cea-03520558\/file\/RF%20heating%20scenarios%20on%20WEST%20Goniche%20FEC2020%20paper.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Introduction: Group 3 pulmonary hypertension (PH) is a common complication of advanced chronic lung disease, with no demonstrated benefit of specific therapy. Objectives: Our hypothesis was that group 3 PH is associated with a more severe baseline presentation and a worse prognosis compared to group 1 pulmonary arterial hypertension (PAH), chronic thromboembolic PH (group 4) and group 5 PH. Methods: We retrospectively analysed consecutive incident patients with PH, from a single center between January 2006 and November 2014. Data were acquired from a prospective database. Clinical, functional and haemodynamic characteristics as well as survival were compared between the 4 precapillary PH groups. Results: 363 patients were included, with a median age of 69 years. 164 patients (45.2%) belonged to group 1 PAH, 109 (30%) to group 3 PH, 65 (17.9%) to group 4 and 25 (6.9%) to group 5 PH. Group 3 patients had more frequently NYHA class III or IV. Patients with groups 3 and 4 PH were older, had significantly lower 6 minute walk distance, higher mean pulmonary arterial pressure, higher pulmonary vascular resistance and lower cardiac index. Group 3 patients had significantly lower values of total lung capacity, forced vital capacity and carbon monoxyde transfer coefficient (KCO). PH specific therapy was used in 90.9% of group 3 patients. Compared to PAH, group 3 patients had significantly higher mortality. In multivariate analysis, age > 65 years and group 3 PH were significantly associated with mortality. Conclusions: Patients with group 3 PH are older, have more severe clinical, functional and haemodynamic characteristics, and worse survival, than PAH patients, despite specific therapy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79336751,"openaccessinfo":{"externalids":{"MAG":"2556764906","ACL":null,"DOI":"10.1183\/13993003.CONGRESS-2016.PA2447","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Type 2 diabetes mellitus (T2DM) is closely associated with the risk of developing cardiovascular complications. A new approach to treatment of T2DM, based on the inhibition of the sodium-glucose cotransporter type 2 (SGLT2) ensures reliable insulin-independent glycemic control with quick overcome of glucotoxicity, reduction of insulin resistance, and positive effects on body mass, blood pressure and other rates. Besides, pronounces clinical efficacy of SGLT2 inhibitor is marked by its use safety and minimized frequency of adverse events. Along with this, the results of carried-out, randomized clinical studies of cardiovascular safety of different SGLT2 inhibitors showed, that apart from bearing on the risk factors, the inhibition of sodium-glucose cotransporter type 2 leads to cardioand renoprotective effects. In addition, their influence on cardiovascular and renal outcomes is the stronger the more different the pre-existing status of cardiovascular diseases of the patient is, the condition of his renal function and the severity of albuminuria. This article summarizes the main results of carried-out randomized clinical studies of SGLT2 inhibitors, which demonstrate their cardiovascular advantages and compile encouraging results of multicentered studies VERTIS, examining different aspects of the use of the ertugliflazine SGLT2 inhibitor in patients with type 2 diabetes. There is data provided demonstrating a powerful glucoselowering, body-mass lowering and hypotensive impacts of ertugliflazine comparable to the same performance of the best representatives of the class. This article describes an evidence base of the use of the drug in monotherapy and its ability to be combined with other oral hypoglycemic agentsand highlightes a high level of safety of the use of ertugliflazine correspondinding to minimized frequency of adverse outcomes of SGLT2 inhibition and so the potential of SGLT2 inhibitors as a new promising class for the treatment of patients with type 2 diabetes and established cardiovascular disease is revealed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":240661181,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21518\/2079-701x-2020-7-32-41","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.med-sovet.pro\/jour\/article\/download\/5653\/5152","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Liquefied petroleum gas is an alternative, relatively clean and a supreme source of energy, which is being used as a key component in the global energy supply. The international trade agreements and the chemical and non-chemical demand of liquefied petroleum gas with the increase in the world's population have brought its production from the processing of natural gas to the limelight. During its processing, a variety of different components are extracted from it, including methane and ethane which remains in the bulk as natural gas. The objective of this research work is to find the capability of investigating the liquefied petroleum gas recovery performance to make the process economical by saving the processing cost and energy. The novelty of this work is to deal with the design and simulation of a liquefied petroleum gas plant using Aspen HYSYS. To make this process energy efficient and economical, different schemes of process alternatives were applied by reducing the sizes of the exchanger and other pieces of equipment. Three cases are studied in which feed is precooled by rerouting the stream and\/or by repositioning of the chiller for the recovery of liquefied petroleum gas from natural gas by analyzing their cost and process parameters. The modelling and simulation base case and three different case studies are realized in Aspen HYSYS. It has been observed that case study 2 results in about 10% increase in LPG production where the chiller is repositioned in the separation section of the LPG production flowsheet. Case study 3 shows a maximum decrease in hot side utilities in the flowsheet of about 20% while 10 and 14% decreases are observed for case studies 1 and 2, respectively. Furthermore, economic analysis indicates about 18 and 22% in the capital cost for case studies 2 and 3, respectively, due to the lower size of process units. The outcome of this investigation is to present plenty of suggestions to improve the process efficiency and minimize the requirement to over design the plant components.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1}},"corpusid":245427427,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fenrg.2021.785827","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3389\/fenrg.2021.785827","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The currently available treatment techniques for concrete structures affected by alkali-silica reaction (ASR) are limited and electrochemical lithium migration has been proposed as an alternative. Lithium compounds have shown to have beneficial effects on ASR expansion when used as admixtures to fresh concrete. During the electrochemical treatment, lithium ions area transported into concrete (or mortar) by the action of an electrical field. The same principle is behind well-established techniques such as electrochemical chloride extraction (ECE). Like during ECE treatments, the reinforcement may be used as cathode during electrochemical lithium migration. In this paper, an investigation of the use of an embedded cathode during electrochemical lithium migration is presented. Mortar specimens were cast with embedded titanium meshes, which worked as cathodes. Results showed that potassium and sodium ions accumulated in the region around the embedded mesh and, under the tested conditions, few lithium ions reached that area. The accumulation of sodium and potassium is an undesirable side effect that increases the pH, which may possibly induce further ASR development, if not enough lithium ions reach the area.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":103094667,"openaccessinfo":{"externalids":{"MAG":"2814063300","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To determine the effect of F ions on the structure of the molten alkali silicate systems, quenched Na2O-SiO2-NaF systems were investigated by Raman spectroscopy and molecular dynamics simulation. The systematic increase of 1100 cm\u22121 band intensity in the Raman spectra of the silicate melts accompanying the replacement of O by F provides the evidence for concomitant polymerization of melts. From the molecular dynamics simulation, it was confirmed that most of substituted F was mainly coordinated to Na+ ions but not Si4+ ions at least up to 12.5 mol% of F ion content. A small amount of F was found to be coordinated to Si as a non-bridging ion from the molecular dynamics simulation, although there was no recognizable evidence from Raman spectroscopy. These results were consistent with the mechanism in which F associated with otherwise network-modifying Na rather than with network-forming Si. Since F was associated to Na+ ions, the replace of O ion by two F ions promote the polymerization of silicate melts.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":96760001,"openaccessinfo":{"externalids":{"MAG":"2163286413","ACL":null,"DOI":"10.2355\/ISIJINTERNATIONAL.43.1897","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The alkali-silica reaction (ASR) remains a major challenge regarding the durability of concrete structures. The reaction mechanism is not sufficiently understood owing to the difficulty in characterizing the structure of the alkali-silica reaction gel (ASR gel) in concrete. Synthetic ASR gels with different compositions, i.e. Na\/Si and Ca\/Si molar ratios, were synthesized and analysed by Raman spectroscopy and, for comparison,\u00a029Si NMR spectroscopy. The results show that higher Na\/Si ratios increase the number of non-bridging oxygens in the gel structure, thus leading to a decrease in the degree of cross-linking. With increasing calcium content of the sodium-calcium silica gel, the structure tends towards that of C-S-H phases. Raman spectroscopy is a promising method to characterise synthetic ASR gels and provide new information on the effect of alkalis on the gel structure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248465710,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3989\/mc.2022.15621","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/materconstrucc.revistas.csic.es\/index.php\/materconstrucc\/article\/download\/2931\/3784","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Consumption of vegetable crops grown on soil irrigated with industrial wastewater has been the order of the day in most urban towns and cities of Nigeria, despite reports of its serious health impact. This study assessed the possibility of uptake of heavy metals by crops grown on soil receiving industrial wastewater during rainy and dry seasons. The crops investigated are Spinach, Cayenne Pepper, Jute mallow, roselle and lady's fingers okra. The initial composition of the wastewater was analyzed to contain 0.89 mg\/l of chromium, 0.74 mg\/l of cadmium, 1.04 mg\/l of copper and 2.81 mg\/l of iron. Control water used for this experiment contain no trace of any of these heavy metals. The experimental soil was also analyzed and contained 0.10 mg\/kg of chromium, 0.06 mg\/kg of iron before irrigation in dry season. After irrigation at the wastewater plots, the heavy metal concentrations in soil had increased to 6.24 mg\/kg of chromium and 7.50 mg\/kg of iron. In wet season, the concentrations of heavy metals in the soil were 0.00 mg\/kg of chromium and 2.32 mg\/kg of iron before irrigation. After irrigation in wet season, the concentrations increased to 6.01 mg\/kg of iron. Mean difference of heavy metal concentrations were significantly high in vegetables in dry season, with values ranging from 0.03 mg\/kg to 211mg\/kg in wastewater plots, 0.20 mg\/kg to 215 mg\/kg in wet seasons wastewater plots, 0.00 mg\/kg to 157 mg\/kg in dry season. It is however recommended that consumption of vegetables irrigated with domestic\/industrial wastewater be strongly discouraged because of its serious health implications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":197432618,"openaccessinfo":{"externalids":{"MAG":"2951463470","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The nursing staff holds pride of place in medical com-munities amidst the modern dimension of the world's requirements for this profession. In addition to basic professional qualities and competencies, a nurse must have significant spiritual values because it influences the patient's life and health and the treatment of his soul as an essential component of personality, most importantly not only at the final stages of life caused by disease progression but also in remission. The pur-pose of the study is to elucidate research findings to determine the motivation for the spiritual development of personality and spiritual values of a palliative care nurse. Methods. To achieve the purpose, theoretical research methods were used: analysis, synthesis, and generalization. Solving research problems involved the methodology for diagnosing thinking direction and predominant personal motives \"Bookshelf\" (Pomytkin, 2013). The methodology covers the basic qualities of a nurse's spiritual development, as follows: physiological needs, security and confidence, love for neighbor, appreciation and respect, self-actualization, spiritual self-improvement, service, wisdom, righteousness, and holiness. Nurses working in different fields of medical care, including palliative and hospice, participated in the study. Results. It was found that the vast majority of respondents believe that the main directions of their thinking and ideas about personal development are determined by the level of physiological needs, a sense of security and confidence, love, appreciation, and respect. At the same time, holiness, righteousness and wisdom are insignificant to most respondents. According to the questionnaire, we concluded that nurses need in-depth work to actualize their spiritual development to fully cooperate with palliative patients and create the most favorable envi-ronment for their stay in a health care facility, hospice, or home.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":250552380,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"New reports of dinosaur tracksites in the Tuchengzi Formation in the newly established Yanqing Global Geopark, Beijing, China, support previous inferences that the track assemblages from this formation are saurischian-dominated. More specifically, the assemblages appear theropod-dominated, with the majority of well-preserved tracks conforming to the Grallator type (sensus lato), thus representing relatively small trackmakers. Such ichnofaunas supplement the skeletal record from this unit that lacks theropods thus far, proving a larger diversity of dinosaur faunas in that region. Sauropods are represented by medium to large sized and narrow and wide-gauge groups, respectively. The latter correspond with earlier discoveries of titanosauriform skeletons in the same unit. Previous records of ornithischian tracks cannot be positively confirmed. Purported occurrences are re-evaluated here, the trackways and imprints, except of a single possible specimen, re-assigned to theropods. Palecologically the Tuchengzi ichnofauna is characteristic of semi-arid fluvio-lacustrine inland basins with Upper Jurassic-Lower Cretaceous deposits in northern China that all show assemblages with abundant theropod and sauropod tracks and minor components of ornithopod, pterosaur and bird tracks.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13927933,"openaccessinfo":{"externalids":{"MAG":"2007914382","ACL":null,"DOI":"10.1371\/journal.pone.0122715","PubMedCentral":"4406591","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0122715&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose: To investigate the ethnic differences of corneal parameters in Arabs and other ethnicities. Methods: This study recruited 250 Saudi Arabian participants, 18\u201345 years of age. The McMonnies questionnaire was used to exclude participants with dry eye. The KR8800 auto refractometer (Topcon, Japan) was used to measure the refractive error. Oculus Keratograph 4 topography was used to assess 16 corneal parameters, including the k-readings, horizontal visible iris diameter, mean eccentricity index, asphericity, corneal shape factor, corneal flattening factor, sagittal height, sagittal curvature, and vertical palpebral aperture. Results: A statistically significant difference was found between male and female participants. Corneal parameters were compared to other ethnicities, including Caucasians and Asians, and those of Mongoloid origin. The horizontal visible iris diameter was wider in Saudi Arabians than in Asians but similar to Caucasians. The sagittal height was deeper and the corneal shape factor was higher than in the other ethnicities, and the eccentricity index was lower than that in Caucasians and Asians of Mongoloid origin. Conclusion: Our data provided normative corneal parameters of Saudi Arabians that may be useful for ophthalmic clinicians and designers of contact lenses. Furthermore, the parameters suggest that the corneal characteristics of Arabians are distinct from those of major ethnicities.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":233622310,"openaccessinfo":{"externalids":{"MAG":"3139096435","ACL":null,"DOI":"10.2174\/1874364102115010013","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/openophthalmologyjournal.com\/VOLUME\/15\/PAGE\/13\/PDF\/","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Since 1970 the government brings differrenciated pressure to bear on production prices but this policy goes with the emergence of France as a big world food exporter. However since 1974 the instability of external trade and the sensible drop in agricultural income has led, 20 years after the i960's laws, to a new agricultural policy. Despite the large current debates, the definition of this new policy seems to have to await the post-crisis phase.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":152961164,"openaccessinfo":{"externalids":{"MAG":"608441964","ACL":null,"DOI":"10.7202\/701163AR","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Problems inherent in conventional p-n junction solar cells are discussed. The principle of operation of min m.i.s. solar cells is then described. Among other advantages it is shown that the min m.i.s. solar cells are capable of giving a much higher Voc compared to the p-n junction solarcells. Problems associated with the min m.i.s. solar cells are also discussed. These include the incompatibility of light transmission and conductivity properties of the metal contact in the case of the contact covering the whole of the top surface, the contact linewidth\/space ratio in the case of grating cells, resistivity dependence of Voc and degradation of cell performance in time.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109302278,"openaccessinfo":{"externalids":{"MAG":"2028519096","ACL":null,"DOI":"10.1049\/REE.1981.0068","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The recent article by Unno et al. evaluated the preventative effect of potassium-sodium citrate (KNa-cit) in the development of renal microcalculi among patients with a history of calcium component stones. However, I was concerned by the high dropout rate in the KNa-cit group (exposure group) where more than half of the patients (53.1%) from the exposure group were excluded from the analysis, whereas there was no exclusion in the non-exposure group. It is widely known that such differential selection or dropout can result in bias in longitudinal studies. In the present study, the excluded patients were described by the authors as increasing their dose of citrate and switching their treatment plan to surgery with no further details. I would like to know the reasons for the increased dosage and the use of surgical treatment. Did they increase the KNa-cit dose because the current treatment showed no improvement? Did they choose surgical procedures because the stones grew larger? Answers to these questions might threaten the validity of this study, and overestimate the effects of KNa-cit if the answers are yes. In addition, the results from the present study showed a sex difference in that the use of KNa-cit was associated with asymptomatic microcalculi disappearances and fewer pain events in women, but not in men. The authors did not provide an explanation for this observation, but there was a different stone composition by sex at baseline, which could have contributed to the observed results, or could have modified the effects of the treatment. I would like to know the authors' interpretation of this.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32903339,"openaccessinfo":{"externalids":{"MAG":"2569158888","ACL":null,"DOI":"10.1111\/iju.13277","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/iju.13277","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We suggest the use of a Miller capacitor as the variable capacitance circuit of the BJT-VCXO (VCXO using a bipolar junction transistor). When the external MOSFET's gate-drain capacitance is 10 pF, we show that the BJT-VCXO using this variable capacitance circuit has a wide frequency variation of about 500 ppm. Also, we suggest the use of the MOSFET's resistance change as the variable capacitance circuit of the CMOS-VCXO (VCXO using a CMOS crystal oscillator). When the external gate-drain capacitance is 30 pF, we show that the CMOS-VCXO using this variable capacitance circuit has a wide frequency variation of over 330 ppm.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":109272187,"openaccessinfo":{"externalids":{"MAG":"1912095154","ACL":null,"DOI":"10.1109\/FREQ.1996.560246","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Experimental lifetime performance data obtained from 156 straightbred Hereford, Angus, and Shorthorn and 172 first-cross heifers were used to estimate heterosis for economic efficiency in a 100-cow herd at age equilibrium under three culling policies and at terminal ages from 6 to 12 yr. All nonpregnant heifers and cows greater than 9 yr of age were culled. The culling policy for removal of nonpregnant cows from second parity through 9 yr of age were 1) no culling, 2) after two consecutive years (actual), and 3) all (imposed). Efficiency was calculated as input cost per unit of output value. A 10-yr average was used for costs of replacement heifers, cow units, and the ratio of calf:cull cow prices (PR), plus higher and lower PR. Input included costs for both cow units and purchased replacements. Output value included both weaned calves and cull cows. Optimum terminal age was mainly a function of PR: 9 yr for average and high PR, but 6 through 9 yr when PR was low, regardless of culling policy or breed groups. Efficiency differences among culling policies were small for high or average PR, but more culling for infertility was beneficial when PR was low. Estimated reductions in unit costs of output value under any culling policy or terminal age were approximately 6% from crossbred cows plus another 6% from crossbred calves, or a total of 12% from specific three-breed crossing of these British breeds. Cost reductions would be somewhat less for rotation crossbreeding but greater for mating smaller crossbred cows with sires of superior growth-carcass breeds.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43228426,"openaccessinfo":{"externalids":{"MAG":"2422873050","ACL":null,"DOI":"10.2527\/1992.7082328X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Group 3 innate lymphoid cells (ILC3) as a family member of innate lymphoid cells (ILCs), have been defined as novel innate immune cells in the past decade. ILC3 include a variety of heterogenous subsets with different phenotypes and functions, which are mainly distributed in barrier organs such as the intestine, lung and skin. They play an important role in immune regulation, tissue repair and lymphoid tissue formation. However, in various inflammatory diseases, ILC3 become dysregulated and participate in the pathogenesis through secreting a series of cytokines such as interleukin (IL)-17, IL-22, interferon-\u03b3 (IFN-\u03b3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to modulate other immune cells and induce the formation of ectopic lymphoid structures. Therefore, it is of great significance to explore the phenotype and function of ILC3 in order to advance the understanding of inflammatory diseases and find new therapeutic targets. In this article, the phenotypic characteristics, biological functions and research progress of ILC3 in inflammatory diseases were reviewed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248503636,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An analytical approach is presented to obtain the sloshing natural frequencies and modes of ideal liquid in a rigid cylindrical container with a rigid annular baffle. The free surface waves of the liquid are considered in the analysis. The artificial interfaces are introduced to divide the complicated liquid domain into several simple sub-domains. The exact analytical solutions of velocity potential of liquid corresponding to every sub-domain are obtained by using the method of separation of variables and the superposition principle. The Eigen-frequency equation is precisely derived by using the Fourier-Bessel expansion on the free surface and the artificial interfaces of the liquid. The convergence study shows high accuracy and fast convergence of the present approach. The comparative studies with those available from literature are made, excellent agreements have been achieved. Numerical results showing the variations of natural frequencies and modes versus position and inner diameter of the annular baffle are provided.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":122311812,"openaccessinfo":{"externalids":{"MAG":"2063143789","ACL":null,"DOI":"10.3233\/SAV-2012-0681","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract In this paper, I pursue the question whether extending democratic rights to work is good in the broadest possible sense of that term: good for workers, firms, market economies, and democratic states. The argument makes two assumptions in a broadly consequentialist framework. First, the configuration of any relationship among persons in which there is less rather than more coercion makes individuals better off. Second, extending democratic rights to work will entail costs and benefits to both the power and authority of employers and meaningful work for employees. These costs and benefits cannot be determined in advance because they are largely empirical, but there are still good reasons for expanding worker participation all-things-considered. First, I examine the parallel case for extending democratic rights to the workplace based on several similarities between politics and work organization. In addition, I consider the objections from voluntariness and efficiency. Although both objections raise interesting problems I believe that a properly formulated conception of democratic workplaces can answer them. In the final section, I sketch a minimal conception of these rights at the level of the firm that does not require a large-scale transformation of the market economy.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":154712592,"openaccessinfo":{"externalids":{"MAG":"2083709018","ACL":null,"DOI":"10.1080\/0020174X.2012.696351","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Increased levels of lactic dehydrogenase (LDH) in the cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. No studies have been performed on patients with Guillain\u2013Barr\u00e9 syndrome (GBS). Aims: To study LDH isoenzymes in CSF of children with GBS. Methods: CSF samples collected from nine patients with GBS were analysed for total LDH isoenzymes activity, and compared to samples from 15 patients with normal results. Results: Mean total LDH activity was 33.33 (6.63) U\/l. All patients had significantly increased LDH-3 isoenzyme compared to controls. LDH-3 was the predominant fraction, accounting for more than 50% of total LDH activity and present in more than twice the percentage of LDH-1 or LDH-2. By contrast, in the control group, there were high percentages of mainly LDH-1 and LDH-2. Conclusions: GBS is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-3, as serial CSF analyses are unavailable, and to determine the optimum time of analysis when this finding first becomes detectable.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":23677534,"openaccessinfo":{"externalids":{"MAG":"2007227832","ACL":null,"DOI":"10.1136\/adc.87.3.257","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/adc.bmj.com\/content\/archdischild\/87\/3\/257.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"IT IS our usual practice in January of each year to make known to our readers any proposed changes in the policy of the editors and in the content of the Journal for the coming year. Little space need be devoted to this subject on this occasion. We believe that we have arrived at a format which meets the requirements of our readers and fills a need in medical literature. If we are mistaken in our assumption, then only our readers can correct us. After three years it has been decided to discontinue the Industrial Health series. This is done because we believe that many of the aspects of this speciality which are of general interest have been adequately covered. An extension of the series would inevitably lead to the inclusion of papers of a particular interest to a restricted number of people. In place of the Industrial Health articles a new series entitled' The Significance of Clinical Manifestations in Childhood' appears. This series is under editorship of a member of our editorial board, DR. c. W. KESSON. The aim is to present a discussion of the significance of some common symptoms or physical signs in childhood. The first in this series is ' Convulsions in Childhood' which appears in this issue. Other papers which win appear in the course of 1959 deal with vomiting, jaundice, diarrhoea, blindness, haemorrhages, deafness and so on. These are, then, the sum total of the changes in our Journal. We hope that in this New Year our established readers will continue to derive pleasure and enjoyment from our pages and that new readers win find that an hour with this Journal is one well spent.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153006290,"openaccessinfo":{"externalids":{"MAG":"2953898049","ACL":null,"DOI":"10.1111\/j.1742-1241.1959.tb03709.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Experimental and theoretical work is reported on four tasks: bundle geometry (wrapped and bare rods), subchannel geometry (bare rods), LMFBR outlet plenum flow mixing, and theoretical local temperature files in LMFBR fuel rod bundles. (DLC)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210251229,"openaccessinfo":{"externalids":{"MAG":"2985584442","ACL":null,"DOI":"10.2172\/6735941","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/digital.library.unt.edu\/ark:\/67531\/metadc1191820\/m2\/1\/high_res_d\/6735941.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The issue of the effective enforcement of public obligations is of the essence in case of the increasing migration of people to various directions, as well as the intensifying flow of international capital. For these reasons it was necessary to establish legal frames for the assistance between the EU member states for the recovery of public claims. The main purpose of the work was to show the development of recovery of public claims of EU member states for the recovery of public claims. First part of work shows short historical outline of European regulations concerning international mutual assistance for the recovery of public claims. The main part of work concentrates on current legal frames of forms of mutual assistance. Current EU regulations retains three forms of mutual assistance the provision of information by one member state, notification of an interested party or other persons of legal acts, and enforcement or indemnification of public claims. The most significant form of mutual assistance specified as the fundamental one is the assistance for the recovery of claims. A wider analysis of the discussed issue shows that international mutual assistance of the member states for the recovery of public claims will further deepen.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":159100291,"openaccessinfo":{"externalids":{"MAG":"223960521","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Today, embedded systems often consist of many different processing, communication, and memory units. This makes an embedded system a multiprocessor system. There are usually many possible multiprocessor architectures and therefore we need tool support for fast evaluation of numerous design alternatives. However, there is a lack of this type of tools which is partially caused by the inherent complexity of the design process. On the other hand, most designers do not have enough confidence to use and trust such tools, since the designer interaction with a tool is usually strongly limited.\n\nThe special concern in this work are memory constraints. This is motivated by the fact that memory is a dominant factor in current designs. The memory influences the performance of embedded systems as well as their energy consumption. There are different types of optimizations which can improve memory utilization. Design space exploration can identify those designs which use memory system efficiently.\n\nThis thesis presents a framework, based on constraint programming (CP), for design space exploration. CP suits this task perfectly, since it offers means to model and solve problems with heterogeneous constraints. This framework makes it possible to refine a specification manually by a designer or automatically. The automatic refinement is done by adding constraints produced by specially designed exploration algorithms. In manual case, the designer decides the nature of the refinement constraints. Design space exploration framework provides an invaluable support. It helps to find (near)optimal designs given optimization criterion. When multi-objective criteria is specified then it provides (near) Pareto-optimal designs.\n\nThis thesis shows that despite the complexity of architecture selection, task assignment, task scheduling, data assignment, and data access scheduling problems, the designer is not left unaided. The presented formulation using a constraint framework coupled with problem specific search heuristics makes it possible to efficiently prune a huge design space. The exploration space pruning helps to find better designs within the same exploration time limit.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":35894736,"openaccessinfo":{"externalids":{"MAG":"859441851","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this research perspective and attitude about the role of women in institutions, jobs and career advice in creating women's employment in Isfahan is a survey research methods are statistical and society to include all women at the time of research of educational services, students and professional are advice Job had requested. Simple random sampling method among women was above the number of centers 142 women in this study were included as examples. Questionnaire data collection tool that is made through the study of the validity of teachers and eliminate ambiguous questions (content validity) and to assess its reliability and alpha Kronbakh method established that 86% figure for total questions has been reported . In order to analyze the data from descriptive and inferential statistical methods (K square test) revealed that variance was used. The results indicate that the type of skills and employment between women and their attitudes toward career counseling programs Meaningful relationship exists. The job counseling programs for increasing women's skills and abilities are useful and effective","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":74687832,"openaccessinfo":{"externalids":{"MAG":"2188312028","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Infectious spleen and kidney necrosis virus (ISKNV) has been reported in the ornamental fish and this virus belongs to the genus Megalocytivirus. Even though this \nvirus have been reported in many countries such as Japan, China, Korea, Taiwan,Thailand and Singapore, the impact and extent of this disease is unknown hitherto at \nMalaysia. This is due to lack of knowledge on the host range, geographical distribution and the differences between strains if any. Hence to elucidate this gap of knowledge,'gold standard' OIE reference polymerase chain reaction (PCR) assay was utilized to detect the presence of ISKNV in farmed ornamental fish from Peninsular Malaysia. A total of 210 ornamental fish samples were collected. Of these, ISKNV was detected in 36 ornamental fish samples and they were asymptomatic. Three restriction enzymes analyses showed that the fish were infected by identical strains of same virus species \nwithin Megalocytivirus genus. Major capsid protein (MCP) gene of 10 ISKNV strains were sequenced and compared with 9 other reference nucleotide sequences acquired \nfrom GenBank. Sequence analysis of MCP gene showed that all strains detected in this study were closely related to the reference ISKNV with nucleotide sequence homology \nranging from 99.8 % to 100 %. In addition, phylogenetic analysis of MCP gene revealed that the reference ISKNV which was obtained from GenBank and all other strains that were detected in this study were included in genotype 1. Since all the infected fish appeared healthy, there was a concern over possible transmission of asymptomatic ISKNV infection in freshwater ornamental fish species. To clarify this, an experimental trial was conducted to investigate the possible transmission of ISKNV infection in ram cichlid by cohabitation. The ISKNV is able to transmit from treated fish to cohabited fish within first week of trial and the infected fish were asymptomatic. The presence of ISKNV in the experimentally infected fish was confirmed by PCR assay and histopathology. The ISKNV carrier pose serious risk to the Malaysian aquaculture industry as this virus can spread without any sign of disease. The inclusion body-bearing cells (IBCs) which are pathognomonic for Megalocytivirus infection were present in the liver and spleen. In addition, other histopathological changes such as accumulation of inflammatory cells in splenic pulp and well defined melano-macrophage centers varied from yellow-brown to black deposition of melanin were noted in the spleen. Visual inspection for clinical signs is not suitable to monitor ISKNV infection as this disease can be asymptomatic in fish. Hence, a highly specific and simple loop-mediated isothermal amplification (LAMP) method was developed in this study for the detection of ISKNV. A set of four primers was designed based on the ISKNV MCP gene sequences. The optimum temperature and time for the LAMP assay were 65 oC and 60 min, respectively. This assay does not require any sophisticated equipments and allows the investigators to carry out the diagnostic test at farm. Compared to other molecular diagnostic methods such as PCR and qPCR, the reaction time for LAMP assay is shorter and gives instant result without the need of any lengthy post reaction procedures. Accurate identification of the pathogens using highly specific diagnostic tool is paramount to control the spread of infectious diseases. One of the advantages of present LAMP assay was its specificity towards ISKNV. The primers were specific for ISKNV and there was no cross amplification with red sea bream iridovirus (RSIV), white spot syndrome virus (WSSV), Aeromonas hydrophila or Vibrio parahaemolyticus. The detection limit of LAMP assay was 20 fg. Diluted acridine orange was used to detect the presence of amplified product and this novel step turns the amplified LAMP product into yellow indicating positive reaction and remains orange on negative reaction. In addition, usage of acridine orange in LAMP product gives clear qualitative result which can be visualized without the aid of special lighting or agarose gel electrophoresis. \nIn summary, the extent of ISKNV infection in farmed ornamental fish which includes information on the host range and geographical distribution in Peninsular Malaysia has been revealed in this study. This baseline information is essential to mitigate the spread \nof this disease. Present study also confirms the transmission of the asymptomatic ISKNV infection in ram cichlid by cohabitation. There were no previous reports on the transmission of asymptomatic ISKNV by cohabitation. The current LAMP technique for \nthe detection of ISKNV is a simple, specific and inexpensive diagnostic tool under laboratory conditions and also in the field.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":90479828,"openaccessinfo":{"externalids":{"MAG":"2792825814","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Anthropology's recent turn to ontology extends a trajectory of rethinking established analytical domains, such as kinship, politics, and ritual. I reassess ritual by exploring the concept of \"showing\" among Chagga-speaking people of Rombo District, in Tanzania's Kilimanjaro Region, where substances such as eleusine (finger millet), entrails, milk, and beer have the capacity to reveal the past and point to the future. Through this case, I consider the analytical limitations of notions such as \"interpretation,\" \"symbol,\" and \"signification\" as I investigate how \"showing\" and the substances it involves acquire a conceptual character and the capacity to enunciate Deleuzian \"events.\" \"Showing\" is thus revealed as a moment that posits and creates concepts, a revelation that transforms and reorients anthropological notions of ritual.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":143000211,"openaccessinfo":{"externalids":{"MAG":"1887926972","ACL":null,"DOI":"10.1111\/AMET.12119","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PCB technology is particularly important in electronic industry. However, the increasing of technology complexity makes it difficult to inspect the quality of PCB. AOI system greatly improves the PCB inspection efficiency, and it has become one of the most instructive subjects that how to identify the text information in the chip image rapidly and accurately. Since the chip images have complex natural background, and are greatly affected by light, shadow, noise, font and size, texture, color, position and arrangement., it is often difficult to inspect, extract and identity the text.This paper presents an effective algorithm of scene character segmentation and recognition in natural scene images. The algorithm segments lines of character,then segments every line of character into individual words for further processing,such as feature extraction and character recognition according to the known features of character. After the segmentation of character, we use an advanced BP algorithm to recognize the character. It improves BP mainly through restructuring gradient in the SIGMOID. The experiment shows a significantly improvement in PC: the recognition accuracy rate of this system is above 96% and the response time is 5ms\/100 words.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":65319973,"openaccessinfo":{"externalids":{"MAG":"2750503732","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Spontaneous and experimentally induced twinning and conjoined placentation were studied in Swiss-Webster (SW) mice. Conjoined placentation was noticed at a rate of 0.4% for twins and 0.06% for triplets. Placentally conjoined embryos were either symmetrical or asymmetrical. A single spontaneous monozygotic conjoined twin was observed among 2,000 blastocysts cultured in vitro. The yield of twins could not be increased by manipulating explanted embryos in vitro, or by treating in utero during the early postimplantation stage of development with vincristine.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38100342,"openaccessinfo":{"externalids":{"MAG":"1982714933","ACL":null,"DOI":"10.1002\/JEZ.1402210110","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The word \"theranostic\" derives from the fusion of two terms: therapeutic and diagnostic. It is a promising research field that aims to develop innovative therapies with high target specificity by exploiting the therapeutic and diagnostic properties, in particular for metal-based nanoparticles (NPs) developed to erase cancer. In the framework of a combined research program on low dose X-ray imaging and theranostic nanoparticles (NPs), high resolution Phase-Contrast Tomography images of mice organs injected with gadolinium and gold-NPs were acquired at the European Synchrotron Radiation Facility (ESRF). Both compounds are good X-ray contrast agents due to their high attenuation coefficient with respect to biological tissues, especially immediately above K-edge energy. X-ray tomography is a powerful non-invasive technique to image the 3D vasculature network in order to detect abnormalities. Phase contrast methods provide more detailed anatomical information with higher discrimination among soft tissues. We present the images of mice liver and brain injected with gold and gadolinium NPs, respectively. We discuss different image processing methods used aiming at enhancing the accuracy on localizing nanoparticles.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":126359001,"openaccessinfo":{"externalids":{"MAG":"2789933666","ACL":null,"DOI":"10.1088\/1748-0221\/13\/01\/C01049","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Experimental and computational studies of the turbulent flow field in a model gas turbine disk cavity have been carried out. The experiments were performed in a rig which features a rotor disk- stator disk configuration with stator vanes, rotor blades, and rim discouragers with axial overlap. Particle Image Velocimetry was used to map the flow field in the cavity at three positions along the axial gap between the disks for various mainstream and secondary air flow rates, and rotor speeds. Static pressure distribution in the cavity at the stator disk and the circumferential distribution of the same at the mainstream passage outer shroud were measured. A recirculation region developed radially inboard in the disk cavity where a strong radial outflow was found close to the rotor disk and a weak radial inflow near the stator disk. This is the source region where the rotation of the core fluid is minimal, its radial extent increasing with the secondary air flow rate. Radially outboard, in the core region, the flow was rotation-dominated except when the secondary air flow rate was high. The peak-to-peak amplitude of the circumferential pressure asymmetry in the mainstream flow path increased as the square of the main air flow rate, attained its maximum value at the stator vane exit, and decreased rapidly downstream. For the experiments performed, no circumferential pressure asymmetry could be found in the disk cavity, even near its rim. The rotating fluid in the core region of the cavity gave rise to an adverse radial pressure gradient, its magnitude increasing as the secondary air flow rate decreased. This feature can facilitate ingress of mainstream gas into the cavity. Concurrently with the experiments, the flow field was simulated numerically using the commercial CFD code FLUENT\/DNS. The agreement between the measurements and the computed results is generally good.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110344037,"openaccessinfo":{"externalids":{"MAG":"2181488185","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Naked barley (Hordeum vulgare var. nudum L.) is a traditional, culturally important, climate-resilient winter cereal crop of Nepal. Evaluation of the naked barely genotypes for yield and disease is fundamental for their efficient utilization in plant breeding schemes and effective conservation programs. Therefore, to identify high yielding and yellow rust resistant landraces of naked barley for hilly and mountainous agro-ecosystem, twenty naked barley landraces collected from different locations of Nepal, were evaluated in randomized complete block design (RCBD) with three replications during winter season of 2016 and 2017 at Khumaltar, Lalitpur, Nepal. Combined analysis of variances revealed that NGRC04902 (3.46 t\/ha), NGRC00886 (3.28 t\/ha), NGRC02309 (3.21 t\/ha) and NGRC06026 (3.10 t\/ha) were the high yielding landraces and statistically at par with the released variety 'Solu Uwa' (3.15 t\/ha). The landraces namely NGRC00837 (ACI Value: 1.86) was found resistant to yellow rust diseases. Landraces NGRC06034 (131.7 days) and NGRC02363 (130.8 days) were found early maturing and NGRC02306 (94.36 cm) was found dwarf landraces among tested genotypes. These landraces having higher yield and better resistance to yellow rust need to be deployed to farmers' field to diversify the varietal options and used in resistant breeding program to improve the productivity of naked barley for Nepalese farmers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":214620372,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ensemble performance of ML decoded turbo codes using coherent BPSK signaling on fully interleaved (memoryless) Rician fading channels is considered, where the ensemble is generated by a uniform choice of the interleaver. The improved bound proposed here is advantageous over the ubiquitous union bound, and it is especially pronounced in the rate region exceeding the cutoff rate (where the performance of turbo codes is most appealing but the union bounds become useless). The upper bounds are compared to simulation results of the log-MAP iterative decoding algorithm for various degrees of space diversity, demonstrating a good match. Hence the improved bounds can be used also as a fast technique to approximately assess the performance of efficient iterative decoding.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":22674952,"openaccessinfo":{"externalids":{"MAG":"2158563943","ACL":null,"DOI":"10.1109\/ICC.2000.853565","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The magnetic characteristics of Goss-oriented 3% silicon-iron are dependent to a large extent on mechanical stress. This paper describes some effects of applying orthogonal planar stresses to single samples of commercial silicon-iron. Tensile or compressive stresses up to 10 MN\/m2were applied simultaneously along and perpendicular to the rolling direction and the material was magnetized along either direction sinusoidally up to 1.7 T. Power loss and magnetostriction were measured under various stress conditions. The stress dependence of the properties did not vary with flux density in the samples tested. Orthogonal stresses of opposite signs always caused a degradation of properties whereas stresses of the same sign usually improved the characteristics. Previously, it has been shown that a stress in the transverse direction had the same effect as a longitudinal stress of half its value. In these experiments this was found not to be the case possibly because the elastic properties of the steel were different due to complex coating stresses.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":2}},"corpusid":121667157,"openaccessinfo":{"externalids":{"MAG":"2042749381","ACL":null,"DOI":"10.1109\/TMAG.1978.1059884","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper inquires into the relation between the reality of Jacobean politics and the rise of English Tacitism. King James I's unruly desire to extend his prerogatives brought about the encroachment upon old liberties of the commons and freedom of speech. The Jacobeans were prompted to seek a voice warning of the dangers of royal misrule, when they recognized the potential perils of James's prerogatives. Tacitism served as a rallying cry against the incipient tyranny, as Tacitus's historiography was based on antipathy towards tyrannical rule, and as its method was to critique the present state through parallels between the past and the present. James's reign was characterized as a tug of war between the King and the adherents of Tacitism, as the tension between the two heightened. This paper investigates this power struggle between the monarch and the English Taciteans through a study of Sejanus, where Ben Jonson uses Tacitus as a means of political criticism. Jonson adopts the Tacitean method in his work by uncovering a true picture of his times through depictions of similarities between Tiberian Rome and James's England. Not only in the place of Jacobean court but also in the literary world did English Taciteans strive to offer political advice.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":153608394,"openaccessinfo":{"externalids":{"MAG":"1903490362","ACL":null,"DOI":"10.17054\/MEMES.2014.22.1.95","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently the trade show is a massive marketing effort of a particular industry and introduces new products to potential customers, as well as the ability to elevate the brand\"s image and corporate identity. It is increasing its importance as a venue of communication. In these changes, the exhibition is required to have the emotional approach to enhance the dynamic and creative image of companies. Therefore, the product itself as well as the importance of various visual contents of the exhibition is increasing positive effect of the image and marketing on their products. In this sense, this study analyzes video contents of the exhibition that was held in Amsterdam, the Netherlands, Europe\"s largest display show \"ISE (Integrated Systems Europe)\" in 2013, focusing on the domestic company, Samsung, LG Electronics and other four foreign companies. The analysis is based on the Herbert Zettl's applied media aesthetics related to the video contents, through which we can find the way to the development of exhibition video contents making for Trade show.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108931145,"openaccessinfo":{"externalids":{"MAG":"1591231260","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"IT HAS BECOME evident in recent years that the syndrome of \"inappropriate\" secretion of antidiuretic hormone (ADH) 2 is a manifestation of various diseases of multiple and unrelated etiologies. 1 The syndrome has been reported in association with bronchogenic carcinoma, 2 cerebral disease of several kinds 3-5 (neoplasm, vascular accidents, head trauma, malformations, tuberculous meningitis), 6,7 acute intermittent porphyria, 8,19 and tuberculosis (miliary and advanced pulmonary). 9 The single endocrinological disturbance implicated in association with this syndrome to date has been hypothyroidism. Goldberg and Reivich 10 recently reported a case of myxedema manifesting impaired water excretion and hyponatremia consistent with inappropriate secretion of ADH. Their patient's hypothyroidism was secondary to the administration of radioactive iodine. We believe that we have observed the syndrome of inappropriate secretion of the antidiuretic hormone in a patient with primary (idiopathic) hypothyroidism. Report of a Case The patient (No. 09-65-71), a 73-year-old Spanish-American woman, was admitted to the Bernalillo County-Indian Hospital","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":2}},"corpusid":46615758,"openaccessinfo":{"externalids":{"MAG":"2066755001","ACL":null,"DOI":"10.1001\/ARCHINTE.1965.03870060069014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": Gunshot injuries involving the head and neck confer a high potential for profound morbidity and mortality rates by damaging vital neurovascular structures, including the central nervous system, carotid arteries, and jugular veins. The main manners of firearm-related death comprise homicide, suicide, and accidental events, the rates of which largely vary depending on region and country. Although a bullet is commonly thought to travel through the body in a straight line, a few patients with head and neck gunshot injuries who survived without lethal organ damage thanks to a nonlinear bullet trajectory have been reported. However, there is no report of a patient who survived a gunshot wound transversely penetrating the entire neck across its deep structures. India's rates of violence vary greatly and in a majority of firearm related injuries illegal, unlicensed weapons are used. As in 2006, India was home to roughly 40 million civilian firearms, out of an estimated 650 million civilian owned guns then believed to exist worldwide. But only 6.3 million (just over 15%) are licensed. The unpredictable nature of the bullet also emphasizes the importance of projecting the missile trajectory. A missile trajectory-tracing software program could be an important tool in the diagnosis and management of patients with bullet injuries.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":245759808,"openaccessinfo":{"externalids":{"MAG":"3214182266","ACL":null,"DOI":"10.5281\/ZENODO.5656741","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reports the permanent deformation evaluation of crushed rock under repeated cyclic loading triaxial tests performed at different stress levels, in order to improve permanent deformation prediction for unbound granular materials (UGMs). Road rutting is the main cause of damage in flexible pavements which the most explanation is crushed rock still not obviously understanding about plastic deformation under service load. The permanent deformation that accumulates under the repeated loading can normally describe and define the types of responses. Theoretical approach of the UGMs permanent deformation used to describe the behaviour of tested materials subject to repeated cyclic loading triaxial (RLT) tests by macro-mechanical observations of the UGMs response. The plastic limit is able to use predict the accumulated plastic deformation in the UGMs layer of road pavement or whether deterioration will be unacceptable. Tested material will be determined the limit of working stress level and the plastic deformation should be considered in this behaviour. The paper presents permanent deformation prediction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59448058,"openaccessinfo":{"externalids":{"MAG":"2284074617","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Domain generalization (DG) aims to learn a robust model from source domains that generalize well on unseen target domains. Recent studies focus on generating novel domain samples or features to diversify distributions complementary to source domains. Yet, these approaches can hardly deal with the restriction that the samples synthesized from various domains can cause semantic distortion. In this paper, we propose an online one-stage Cross Contrasting Feature Perturbation (CCFP) framework to simulate domain shift by generating perturbed features in the latent space while regularizing the model prediction against domain shift. Different from the previous fixed synthesizing strategy, we design modules with learnable feature perturbations and semantic consistency constraints. In contrast to prior work, our method does not use any generative-based models or domain labels. We conduct extensive experiments on a standard DomainBed benchmark with a strict evaluation protocol for a fair comparison. Comprehensive experiments show that our method outperforms the previous state-of-the-art, and quantitative analyses illustrate that our approach can alleviate the domain shift problem in out-of-distribution (OOD) scenarios.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260926332,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2307.12502"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nociceptive pain signals are relayed in the spinal cord as they are transmitted from \nthe periphery to higher brain centers. The neuronal populations in the spinal cord that transmit peripheral stimuli are very heterogeneous. This has hampered the \nidentification of interneuron subtypes involved in pain processing and the \ncharacterization of their functional connectivities. In this study, I obtained a \ntranscriptomic profile of spinal cord cells specifically activated by a peripheral painful stimulus using the recently developed phospho-ribosome profiling technique, and identified Protein targeting to glycogen (Ptg) as a pain-induced gene in spinal astrocytes. Ptg is known to play an important role in glycogenesis. I observed elevated spinal cord glycogen levels in response to different painful stimuli and proposed a correlation between the magnitude and duration of glycogen elevation with the persistency of different pain models. Moreover, manipulation of Ptg expression and glycogen metabolism led to altered pain sensitivity. My study points toward a new perspective of the role of astrocytes in pain processing and a potential link between changes in the metabolic state and pain processing in the spinal cord.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":227345059,"openaccessinfo":{"externalids":{"MAG":"3028316433","ACL":null,"DOI":"10.11588\/HEIDOK.00024156","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In microwave processing of dielectric materials which completely fill a waveguide, the distribution of the electric field within the material needs to be known. This paper presents the theoretical conditions for the microwave cure of large pieces, the size of which is more than the wavelength. The mathematical description of heterogeneously multilayer-filled waveguides presents certain difficulties because of the involved transcendental equations. A computer treatment to determine the electric-field spatial distribution is developed. The influence of the dielectric constants and the thickness of the dielectric materials on the spatial distribution of the electric field and power flow in each layer is studied. In particular, the field strength is enhanced in the dielectric with the highest permittivity. A numerical resolution of the transcendental equations defining the cutoff frequencies of propagation modes allows one to enumerate the modes, which can successively appear in a dielectric-loaded waveguide as functions of dielectric and geometric parameters. The attenuation constant and the microwave power dissipated in each material are determined. A balance sheet of energy is established.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":111091951,"openaccessinfo":{"externalids":{"MAG":"2149464778","ACL":null,"DOI":"10.1109\/22.618402","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Technostructural interventions are an expensive typology of organisation development interventions. Commercial banks in Kenya have however been seen to increasingly adopt these interventions in a bid to drive up performance. The literature, on the other hand, indicates that empirical studies on the effects of these interventions have indicated varied results across different sectors and settings. This study therefore sought to establish the effect of technostructural interventions on the performance of commercial banks in Kenya. The typologies of technostructural interventions considered were job enrichment, employee involvement and physical layout. The study adopted a cross sectional research design. Multivariate analysis indicated that job enrichment and physical layout do not have an effect on performance of commercial banks in Kenya. Employee involvement was however found to have a positive and significant effect on the perfomance of commercial banks in Kenya.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":197890737,"openaccessinfo":{"externalids":{"MAG":"2951064623","ACL":null,"DOI":"10.18535\/IJSRM\/V7I6.EM03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Little is known about the importance of mycoplasmas in equine respiratory disease, and this project was undertaken to investigate the occurrence of mycoplasma antibody in horses. Two mycoplasmas, M. equirhinis and an unnamed species, N3, were selected from 13 strains recently isolated from the nasopharynx of horses. Immunization of rabbits and horses resulted in the development of specific antibody. Complement-fixation (CF) was found to be more sensitive than metabolic-inhibition and growth-inhibition for the detection of antibody in equine hyperimmune sera, and this method was used for the survey of antibody in other horses. Six ponies were chosen which were apparently free of mycoplasmas, without CF antibody to M. equirhinis and with low levels to N3. Two were inoculated intranasally with M. equirhinis, two with N3 and two remained as controls. N3 was not recovered from any pony, but within five days M. equirhinis was recovered from every animal, indicating that it had spread naturally from the inoculated ponies to the others. After six weeks it became difficult to isolate the organisms, and levels of CF antibody rose first in the nasal secretions and later in the sera. After several weeks antibody declined to indetectable levels. No clinical signs of infection were seen. In a survey of 817 sera taken over one year from 85 racehorses in seven stables, every horse was found to have CF antibody to M. equirhinis and N3 at some time during the sampling period. In five stables most horses had no M. equirhinis antibody when they entered the stable, but within two months they invariably developed significant titres, implying that they had been infected. When compared with a survey of 256 sera from 81 horses completed two years previously, it appeared that antibody to both mycoplasmas was more prevalent in the recent survey.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":91572849,"openaccessinfo":{"externalids":{"MAG":"2890514064","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The reduction of environmental burdens is required in recent years to mitigate global warming, ozone layer depletion and etc. in manufacturing fields. Hence, prediction system of environmental burden for machining operation has been developed so far. Hence, the evaluation indicator for ecoefficiency of process and operation planning is also proposed with considering the environmental burden, manufacturing time and total number of work piece setup times in this research. Global warming is selected as impact category and the feasibility of the developed system and evaluation indicator for eco-efficiency is demonstrated in this paper.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110429196,"openaccessinfo":{"externalids":{"MAG":"2034782004","ACL":null,"DOI":"10.1299\/JEE.3.307","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\"Acute coronary syndrome (ACS) is a term that encompasses both unstable angina and myocardial infarction (MI) with or without ST-segment elevation. \"It is a life-threatening disorder that remains a source of high morbidity and mortality despite advances in treatment. \"Risk assessment done by using risk factors and risk markers. \"One of the emerged risk markers is high circulating level of PPAR-\u03b3 (a potentially important transcription factor). \"This study represents a try to evaluate the role of this analyte as a risk biomarker for future cardiovascular events, and evaluation of PPAR-\u03b3 as a possible diagnostic biomarker for MI. \"It was a case \u2013control study enrolled 160 subjects; 80 patients diagnosed as ACS patients by expert physicians. \"An equivalent age and sex matched population without coronary disease with similar risk factors considered a control group. Serum levels of PPAR-\u03b3 were measured by using ELISA technique, cTpI was investigated by qualitative membrane- based immunoassay. \"Independent sample t-test was used to compare means between two groups. \"ANOVA were used to compare means between different groups, p value \u2264 0.05 is significant. \"There were significant differences in mean serum levels of PPAR-\u03b3, by patients and control. \"There was a significant difference in PPAR- \u03b3 serum levels between positive and negative cTpI groups. \"There was an insignificant difference in PPAR- \u03b3 level among different ECG finding groups. \"Circulating level of PPAR-","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":124276690,"openaccessinfo":{"externalids":{"MAG":"2470956611","ACL":null,"DOI":"10.21474\/IJAR01\/639","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The increase in electoral volatility in European democracies has raised the question whether volatile voters are just randomly switching or actually making more informed vote choices. This study addresses this question by examining the underlying mechanisms through which political campaign exposure influences two types of electoral volatility: crystallization and conversion. Specifically, it examines how political information efficacy and campaign cynicism mediate the impact of campaign exposure on both types of vote change. We use a Dutch panel survey (N = 1349), collected during the 2014 European Parliament elections. A structural equation model analysis reveals that campaign exposure positively affects electoral volatility, both directly and indirectly via information efficacy. Both effects were especially pronounced among voters who were undecided at the onset of the campaign.1 1 This chapter is under review as: Geers, S., Bos, L., & De Vreese, C.H. (2016). Informed switchers? How the impact of campaign exposure on vote change depends on political information efficacy. International Journal of Communication. INFORMED SWITCHERS? 103","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53532829,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Poly(hydroxybutyrate), or 'Biopol' as it is commercially known, is a naturally occurring, biodegradable thermoplastic, produced by bacterial culture. It can be processed and used in similar ways to conventional thermoplastics, offering the same versatility and convenience, whilst also being much more 'environmentally friendly'. Thus, as a marketable product it has sparked great interest, but to become a commercial success a number of intrinsic difficulties have to be overcome. Although workable, pure PHB has relatively poor mechanical properties with respect to other thermoplastics, and it ages, worsening this situation. It is also difficult to work with because it decomposes at its melt temperature, again depressing its physical properties. The aim of this project was to explore the possibility of using additives to improve the thermal stability of poly(hydroxybutyrate) to enable easier processing of the material. To enable this, new techniques were developed to examine the kinetics and mechanism of degradation, along with methods for determining the effect of additives. By screening a large number of additives, a number of compounds have been identified that demonstrate a stabilising effect, reducing the rate of degradation. The new methods have included quantitative and kinetic measurements by FT-IR upon degrading systems by analysing either the molten polymer, using a heated mirror, or examining the volatile gases in a heated gas cell. A number of modifications to the TVA (thermal volatilisation analysis) apparatus were explored. Internal thermocouples have been shown to be able to detect cold ring formation, and a thermal volatilisation mass spectrometry system (TVMS) was constructed and used to great effect. A technique to quantitatively determine the degradation products from PHB by gas chromatography, was devised, successfully identifying PHB chain fragments up to six monomer units long. This operated by chemically forming derivatives of these degradation products The effectiveness of the additives was examined in a number of ways. Many techniques were discarded, either being too unwieldy or of poor reproducibility. It turned out that weight loss measurements were the most straightforward and reliable, and proved to be effective for rapidly assessing additives. Kinetic measurements were also made using this technique. Molecular weight determinations were performed on degraded samples prepared using the same apparatus, allowing further comparisons and kinetic measurements to be made. A system was designed that made it possible to record IR spectra of a degrading film of the polymer, in real time, that was being heated on a reflective surface. Loss of material from the polymer and changes in its chemical nature could be observed easily, and allowed further comparison of additives. In summary, a number of new and novel techniques have been successfully developed to assess the kinetics and mechanism of degradation, and a number of additives have been identified that demonstrate stabilising effects.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":224439849,"openaccessinfo":{"externalids":{"MAG":"3005508431","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":". Land surface models (LSMs) represent terrestrial hydrology in weather and climate modelling operational systems and research studies. We aim to improve hydrological performance in the Joint UK Land Environment Simulator (JULES) LSM that is used for distributed hydrological modelling within the new land\u2013atmosphere\u2013ocean coupled prediction system UKC2 (UK regional Coupled environmental prediction system 2). Using river flow observations from gauge stations, we study the capability of JULES to simulate river flow at 1 km 2 spatial resolution within 13 catch-ments in Great Britain that exhibit a variety of climatic and topographic characteristics. Tests designed to identify where the model results are sensitive to the scheme and parameters chosen for runoff production indicate that different catch-ments require different parameters and even different runoff schemes for optimal results. We introduce a new parameter-isation of topographic variation that produces the best daily river flow results (in terms of Nash\u2013Sutcliffe efficiency and mean bias) for all 13 catchments. The new parameterisation introduces a dependency on terrain slope, constraining surface runoff production to wet soil conditions over flat-ter regions, whereas over steeper regions the model produces surface runoff for every rainfall event regardless of the soil wetness state. This new parameterisation improves the model performance across Great Britain. As an example, in the Thames catchment, which has extensive areas of flat terrain, the Nash\u2013Sutcliffe efficiency exceeds 0.8 using the new parameterisation. We use cross-spectral analysis to evaluate the amplitude and phase of the modelled versus observed river flows over timescales of 2 days to 10 years. This demonstrates that the model performance is modified by changing the parameterisation by different amounts over annual, weekly-to-monthly and multi-day timescales in different catchments, providing insights into model deficiencies on particular timescales, but it reinforces the newly developed parameterisation","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":264308470,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The main purpose of this paper is to study the stock price jump process is more common than Poisson process -a kind of special renewal process-the incident time interval is independent random variable sequence and identical subordinate to Gamma distribution. The object of study is European bi-direction option, It also known as the double two-way options. Also, European bi-direction option is an exotic option. Then, build up stochastic differential equation under the circumstance of the market no arbitrage based on stochastic analysis and martingale theory. Based on the above discussion, we obtain the European bi-direction option pricing formulas under jump diffusion model by simple mathematical induce by means of martingale method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206888518,"openaccessinfo":{"externalids":{"MAG":"1914216102","ACL":null,"DOI":"10.1109\/IFITA.2009.161","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We developed a highly birefringent micro-structured optical fiber that, in combination with a fiber Bragg grating sensor, allows measuring transverse strains in reinforced composites. The first generation of this dedicated fiber sensor featured a hydrostatic pressure sensitivity of \u221215 pm\/MPa and yielded a transverse strain sensitivity of \u22120.16 pm\/\u00b5\u03b5 when embedded in a carbon fiber reinforced polymer. The second generation of this sensor has now been fabricated and hydrostatic pressure experiments and FEM simulations show that this generation returns a sensitivity of more than twice that of the first generation. FEM simulations additionally show an increased sensitivity when this sensor is embedded in a reinforced composite, achieving an unprecedented transverse strain sensitivity of 0.29 pm\/\u00b5\u03b5. We explain how the optimized micro-structure yields this record-high sensitivity. In addition we demonstrate the selectivity of the bare fiber sensor, which remains insensitive to temperature changes or axial strain. This sensor can therefore play an important role in the domain of structural health monitoring.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-20":1,"2015-11":1}},"corpusid":40705518,"openaccessinfo":{"externalids":{"MAG":"2075109785","ACL":null,"DOI":"10.1109\/ICSENS.2011.6127305","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Kysuce, situated on the border with the Czech Republic and Poland, belongs among distinctive regions in the Slovak Republic. This region offers tourism many interesting sites. Few decades ago, Kysuce offered tourists and visitors well-preserved national architecture, which is nowadays concentrated in an open-air museum Vychylovka. Thanks to the rich afforestation and a sophisticated network of signs for hikers, hiking has been very popular. The ground relief and climatic conditions also encourage winter sports. The world-wide development of geotourism has also concerned this region. Despite a low-varied geological structure, there are unique geological formations that have attracted attention for years. For example, tourists visit the interesting mineralized springs and a remarkable crude oil seep in Korna. Geologically unique are also the occurrences of 'stone balls' from sandstone and conglomerates. This phenomenon has attracted attention of both geologists and esotericism supporters.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":133203955,"openaccessinfo":{"externalids":{"MAG":"2534517991","ACL":null,"DOI":"10.1088\/1755-1315\/44\/3\/032013","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1755-1315\/44\/3\/032013","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A new kind of topographic experiment is presented which makes it possible to depict the energy flow in the three-beam case of diffraction in Laue-Laue geometry. The crystal is illuminated by a highly collimated x-ray beam which is reduced in both cross-section dimensions (pinhole topography). These experiments allow the investigation of the dynamical interaction of the three diffracted waves in three-beam interference and also allow the predictions of the theory to be tested. The results are discussed with reference to the dispersion surface and are compared with the images taken in the arrangement for conventional slit limited section topography.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250789532,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/32\/10A\/328","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article analyzes the history of university studies in relation with the establishment of the Greek elites from the mid-19th century until today, based on primary and secondary sources and on available statistical data. Particular attention is given to studies at universities abroad and to students' pathways. By examining the prominent position of the elites among students abroad we pose the question to what extent there has been a pattern change since the past. We highlight that the possession of a degree adds power to one's personal course, especially in two periods (early 1860s until mid-1890s, end of 1950s until mid-1980s). A common feature of these periods is the upward structural social mobility. During the first and especially the second period, shortages in certain professions, along with state expansion, led to the increase in demand for degrees, aside from immediate graduate absorption. The article also ascertains that lately a \u00abreservoir\u00bb with a significant number of foreign studied Greeks has \u00abaccumulated\u00bb abroad. Though comparable with the case in other European countries, this becomes noteworthy when taking into account the relatively smaller Greek population. This mobility concerned a reasoned economic choice, together with being attributed to the social value attached to education. Simultaneously, it was linked to the expectation of global quality education, acquisition of a personal cultural experience, along with improved credentials that create better professional prospects and high income. Nonetheless, in the case of certain groups, this mobility was governed by the spirit of a family tradition and the reproduction of social and cultural capital.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201034222,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: Formation of TiB2, TiN and Al2O3 powder mixtures were obtained through self-propagating high-temperature synthesis (SHS), starting from TiO2 + BN + Al mixtures. As a diluent, NaCl was added in 0-40 wt% range to the starting mixture in order to refine the size of the formed particles. Thermochemical calculations were performed by Factsage software. The products were subjected to XRD, SEM and particle size analyses. Intended reaction products were obtained in the TiB2, TiN and Al2O3 system according to XRD analyses, with no cross reaction products. The crystallite size of the products decreased with the increasing amount of NaCl according to the broadening of the peaks on the XRD patterns of the products. Particle size measurements revealed that near-nano size particles were formed. A decrease in the adiabatic temperature was calculated, a decrease in the velocity of the SHS wave front was observed and a decrease in the particle size of the obtained products was measured as a result of the increase in the diluent amount.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":249871492,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two-dimensional recursive filters are useful only if stable, that is, if their outputs remain bounded for bounded inputs. The stability of a recursive filter depends on the phase spectrum of its denominator array. A two-dimensional generalization of the discrete Hilbert transform leads to a scheme producing stability with nominal distortions of the filter's desired amplitude spectrum. The method is therefore an attractive alternate to a least-squares procedure recently described by Shanks et al.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":122747120,"openaccessinfo":{"externalids":{"MAG":"2135620361","ACL":null,"DOI":"10.1109\/TGE.1973.294304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 16-wk feeding experiment was conducted to investigate the effects of a prebiotic, isomaltooligosaccharide (IMO), a probiotic, PrimaLac\u00ae, and their combination as a synbiotic on the chemical compositions of egg yolks and the egg quality of laying hens. One hundred and sixty 16-wk-old Hisex Brown pullets were randomly assigned to 4 dietary treatments: (i) basal diet (control), (ii) basal diet + 1% IMO (PRE), (iii) basal diet + 0.1% PrimaLac\u00ae (PRO), and (iv) basal diet + 1% IMO + 0.1% PrimaLac\u00ae (SYN). PRE, PRO, or SYN supplementation not only significantly (P < 0.05) decreased the egg yolk cholesterol (24- and 28-wk-old) and total saturated fatty acids (SFA; 28-, 32-, and 36-wk-old), but also significantly (P < 0.05) increased total unsaturated fatty acids (UFA; 28-, 32-, and 36-wk-old), total omega 6 and polyunsaturated fatty acids (PUFA), including linoleic and alpha-linolenic acid levels in the eggs (28-wk-old). However, the total lipids, carotenoids, and tocopherols in the egg yolks were similar among all dietary treatments in the 24-, 28-, 32-, and 36-wk-old hens. Egg quality (Haugh unit, relative weights of the albumen and yolk, specific gravity, shell thickness, and yolk color) was not affected by PRE, PRO, or SYN supplementation. The results indicate that supplementations with IMO and PrimaLac\u00ae alone or in combination as a synbiotic might be useful for improving the cholesterol content and modifying the fatty acid compositions of egg yolk without affecting the quality of eggs from laying hens between 24 and 36 wk of age.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23077157,"openaccessinfo":{"externalids":{"MAG":"1496947737","ACL":null,"DOI":"10.1111\/1750-3841.12947","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/psasir.upm.edu.my\/id\/eprint\/44048\/1\/Chemical%20compositions%20of%20egg%20yolks%20and%20egg%20quality%20of%20laying%20hens%20fed%20prebiotic%2C%20probiotic%20and%20synbiotic%20diets.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Medication adherence is critical for the realization of pharmacotherapy benefits and reduced healthcare expenditure. Studies have shown up to 60% of people with Multiple sclerosis (MS) experience suboptimal medication adherence, which is associated with poorer health outcomes and subsequent discontinuation. The current systematic review reported on objectively measured adherence and discontinuation rates for self-administered oral and injectable disease-modifying therapies (DMTs). OBJECTIVES: To identify whether, in people with MS, the introduction of oral DMTs has improved medication adherence when compared with injectable DMTs. The secondary aim was to report synthesized objectively measured medication adherence and persistence rates for both oral and injectable DMTs in MS across varying study durations. METHODS: Literature searches were conducted through PubMed, Web of Science, Scopus, and PsycINFO. Inclusion criteria were limited to English, peer-reviewed, objective, self-administered DMT articles, published between July 1993 to December 2019. Publications reporting combined intravenous and self-administered DMT data, or that did not account for DMT switching in discontinuation rates, were excluded. Data were synthesized into observation lengths ranging from less than 8 months to greater than 36 months. Meta-analysis and meta-regression were undertaken on both oral and injectable 12-month adherence and discontinuation data. RESULTS: In total, 61 articles were included; 46 articles examined adherence and 26 examined discontinuation. Twelve-month adherence ranged between 53.0% to 89.2% for oral (N = 7) and 47.0% to 77.4% for injectable DMTs (N = 7). Results from the meta-analysis and meta-regression show significantly higher pooled mean medication possession ratio (MPR) adherence for oral DMTs (91.0%) when compared to injectable DMTs (77.0%) over 12 months (\u03b2 = \u22120.146; 95% CI: \u22120.263 to \u22120.029). Results indicate major asymmetry across studies (LFK index: \u22125.18), proposing the presence of significant publication bias. Mean discontinuation over 12 months was between 10.5% to 33.3% for oral (N = 7) and 15.2% to 50.8% for injectable DMTs (N = 10), with meta-analysis results indicating the presence of significant heterogeneity (I2 Injectable: 99.5%; I2 Oral: 93.1%) between studies included in each subgroup. However, no appreciable difference in mean discontinuation rates across groups (Injectable: 27%; 95% Cl: 19.0%-34.0%; Oral: 24%; 95% CI: 17.0%-31.0%) was found. CONCLUSIONS: Medication adherence for oral DMTs suggests a significant improvement compared to adherence for injectable DMTs. No significant difference in discontinuation rates between oral and injectable DMTs was found. Oral DMT adherence and persistence studies are limited, given their relatively recent introduction. Suboptimal medication adherence and discontinuation issues remain present for both oral and injectable DMTs. Future studies would benefit from improved consistency in methodology, such as comparable adherence and persistence definitions.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-30":1}},"corpusid":237371863,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18553\/jmcp.2021.27.9.1273","PubMedCentral":"10391062","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10391062","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Fischer 344 rats were fed a low-fat high carbohydrate (HC) diet, an isocaloric fat-containing (IC) diet, a hypercaloric fat-containing (HF) diet or a commercial rodent chow. The effects of these diets were studied on the binding of aflatoxin B (AFB1) to exogenous DNA, and on the activities of hepatic glutathione transferases (GSTs), cytochromes 2B1 and 1A1. Microsome-mediated binding of [3H]AFB1 to exogenous DNA was significantly lower in the HC-rats than in the chow and IC-fed rats. No significant differences were noted between HF and either HC or IC rats. There was no significant difference in hepatic GST activity of rats fed the different diets. Our results suggest that high-carbohydrate low-fat diets reduce microsome mediated epoxidation of AFB1 to a larger extent than high-fat diets. In general, high fat diets increased cytochrome 1A1 and 2B1 activities relative to chow and high carbohydrate diet. This suggests greater detoxification of AFB1, thus reducing the amount of AFB1 available for hepatic macromolecular binding.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":37620333,"openaccessinfo":{"externalids":{"MAG":"2418184168","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Clinical case reports, clinical series, and a small number of controlled studies provide evidence that many commonly prescribed psychiatric drugs may have untoward effects on sexual function. Both heterocyclic antidepressants and monoamine oxidase inhibitors appear to be associated with ejaculatory impairment. Erectile dysfunction and retarded ejaculation have been associated with neuroleptics. Several benzodiazepines have been reported to interfere with ejaculation. This information has clear significance for the prescribing physician.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9497219,"openaccessinfo":{"externalids":{"MAG":"2108708894","ACL":null,"DOI":"10.2190\/FL1D-RCW5-2XYN-89LR","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Humans in modern society utilize cell phones, with interest expected to increment constantly in coming years. Cell phone users partly absorb electromagnetic radiation (EMR) through signals from cellular phones. Therefore, understanding the biological effects of radiofrequency electromagnetic radiation (RF-EMR) exposure is very important for human health. Owing to close proximity use of cell phones to user's head, human brain is adversely affected. One of the affected brain regions is known as hippocampus. The major intracellular signalling pathway implemented in the hippocampus includes activation-dependent molecular changes which are mediated by a rise in intracellular calcium leading to the activation of protein kinases. In the literature, little is known about the effects of long term GSM-2100 cell phone radiation exposure on hippocampal levels of kinases including Ca2+\/calmodulin-dependent protein kinase II (CaMKII) and protein kinase A (PKA) on rats. Hence, the present study has been focused on 3G cell phone radiation effects on hippocampal level of kinases with 50 days of exposure. Rats were divided into \"sham-exposed\" and \"GSM-2100 exposed\" groups. Sham-exposed rats were housed in the same room under the same conditions with equal time period without antenna. GSM-2100 exposure group of rats were exposed to 2100MHz RF-EMR emitted from the signal generator for 2 hours per day. Hippocampal level of kinases was determined by western blotting. The comparison of hippocampal levels of CaMKII\u03b1 and PKA between \"sham-exposed\" and \"GSM-2100 exposed\" groups revealed that hippocampal levels of these kinases were significantly higher in \"GSM-2100 exposed\" groups than \"sham-exposed\" groups. Our results provide experimental data suggesting that long term exposure to GSM-2100 cell phone radiation had increased effect on hippocampal kinases which might encourage further research investigating molecular effects of RF-EMR exposure on signaling pathways in the central nervous system.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":212635925,"openaccessinfo":{"externalids":{"MAG":"3009484471","ACL":null,"DOI":"10.1109\/PIERS-Spring46901.2019.9017912","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study tests whether gold can effectively hedge exchange rate risks. We take into account the asymmetric characteristic of exchange rate fluctuations and use the dynamic panel threshold model in order to select gold prices in major gold-related currencies in the world: the Australian dollar, the Canadian dollar, the euro, the Indian rupee, the Japanese yen, the South African rand, and the British pound. Using monthly data from January 1999 to January 2010, with lagged one-period exchange rate returns (US dollar depreciation rate) as the threshold variable, the estimation results suggest that there are two thresholds at -7.5% and -3.7%. These can be divided into regime 1 (exchange rate returns \u2264 -7.5%), regime 2 (-7.5% > exchange rate returns \u2264 -3.7%), and regime 3 (exchange rate returns > -3.7%). Regarding the effectiveness of gold hedging, regime 2 is higher than is regime 3. The risk hedging effect of regime 1 is not significant because it might be caused by the excessive devaluation of the US dollar in the short-term and the overshooting of the exchange rate adjustment, making gold unable to hedge the devaluation risks of the US dollar.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":153737038,"openaccessinfo":{"externalids":{"MAG":"2021144079","ACL":null,"DOI":"10.3846\/16111699.2012.670133","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.vilniustech.lt\/index.php\/JBEM\/article\/download\/3750\/3160","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Issues of public health raised by sickle cell disease and available solutions vary greatly between countries. Two main variables lead the choices: the affordable health resources, and the distribution of the abnormal genes in the population. Three examples have been chosen to illustrate these challenges. 1. In continental France, the level of health resources is good but the distribution of sickle traits is very heterogeneous among the population. Health policies against sickle cell disease aim at organizing screening and care to reach populations at risk, and concentrate the efforts upon them. This task is made difficult by two usual characteristics of these minorities: their rather poor social condition, and their cultural isolation. 2. In Guadeloupe (French West Indies) available health resources are similar to those of France but the sickle trait is common and has a homogeneous distribution in the population (14% carriers). Sickle cell disease is a health priority. Such conditions have recently favoured the organization of an efficient program for prevention and care of the disease. 3. In Benin (West Africa) a very high prevalence of sickle trait (more than 30% individuals are carriers, and about 4% have the disease) comes along with quite precarious resources that have to be shared with several other health priorities. An efficient and sustained policy against sickle cell disease has not yet been developed, which impedes a rational use of the few available resources, and creates much distress for diseased individuals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24472049,"openaccessinfo":{"externalids":{"MAG":"200814882","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim: To assess the effectiveness and cost-effectiveness of a universal childhood varicella-zoster vaccination programme in Belgium (1) using the most recent Belgian data on varicella-zoster burden, (2) exploring different options for the timing of the second dose, (3) obtaining results with and without exogenous natural boosting, and (4) investigating the possible additional benefit of zoster booster vaccination for adults at age 50 or 60 years. Methods: An extensively studied and improved dynamic model is used to estimate primary and breakthrough chickenpox and zoster cases over time. For a range of vaccination options, we compared the direct costs (health care payer perspective) and health outcomes (including Quality-Adjusted Life-Years (QALYs) lost) associated with chickenpox and herpes zoster. Estimates of social contact patterns, health care use, costs and QALY losses are almost exclusively based on Belgian databases and surveys. Results and Conclusions: If exogenous natural boosting exists, a net loss in QALYs is expected for several decades after implementing a universal chickenpox vaccination programme, due to an increase in zoster mainly in persons aged 50-80 years. This result holds also for scenarios that minimise or counteract the expected increase in zoster incidence (e.g. additional booster vaccinations in adults). However, if the boosting hypothesis is not true or if costs and QALYs are cumulated over at least 33 to more than 100 years after vaccination (depending on the assumptions made), different options for universal 2-dose vaccination against chickenpox in Belgium would be cost-effective at a vaccine price of \u20ac43\/dose or lower.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25313913,"openaccessinfo":{"externalids":{"MAG":"2014949716","ACL":null,"DOI":"10.4161\/hv.23334","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/hv.23334?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"When monthly business surveys are not completely overlapping, there are two different estimators for the monthly growth rate of the turnover: (i) one that is based on the monthly estimated population totals and (ii) one that is purely based on enterprises observed on both occasions in the overlap of the corresponding surveys. The resulting estimates and variances might be quite different. This paper proposes an optimal composite estimator for the growth rate as well as the population totals.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":123402123,"openaccessinfo":{"externalids":{"MAG":"2186610963","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Theoretical computations utilising both CCSD and MP2 methods and the cc-pVTZ basis set have been carried out to determine the structures of several conformations as well as the internal rotation potential energy functions for 2-cyclopropen-1-ol, 2-cyclopropen-1-thiol and 2-cyclopropen-1-amine. The energies and wavefunctions for these potential functions have also been computed. Each of these molecules has an energy minimum corresponding to a conformation with intramolecular \u03c0-type hydrogen bonding. The \u03c0 bonding stabilisation is about 2.3\u2009kcal\/mole for the alcohol, 2.1\u2009kcal\/mole for the thiol, and about 2.5\u2009kcal\/mole for the amine. The results for the thiol demonstrate a rare example of intramolecular \u03c0-type hydrogen bonding. The calculated O\u2013H, S\u2013H, N\u2013H, and C=C stretching frequencies have also been compared for the conformations with and without the \u03c0-type hydrogen bonding. The C=C stretching frequency is substantially lower in all cases for the hydrogen bonded conformers. GRAPHICAL ABSTRACT","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":104346325,"openaccessinfo":{"externalids":{"MAG":"2908422901","ACL":null,"DOI":"10.1080\/00268976.2018.1554192","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Alzheimer's disease (AD) is characterized by progressive neurodegeneration. The critical molecular trigger is believed to be the accumulation of A\u03b2 neurotoxic oligomers. Given the proteolytic processing of Amyloid Precursor Protein (APP) by \u03b2-secretase (beta-site APP cleaving enzyme 1, BACE1) as the key step in the building up of A\u03b2 oligomers, BACE inhibitors come with therapeutic prospects of preventing or delaying the onset of Alzheimer's. To find inhibitory peptides against BACE1, a library of 'dark peptides' was constructed from 4400 intergenic DNA sequences of Escherichia coli. The sequence level analysis was followed by protein structure predictions, molecular docking, and simulation. Based on bioinformatics analysis, 5 potential peptides were screened for experimental validation. Out of these two peptides were identified as lead molecules based on BACE1 inhibitory activity, followed by FRET inhibitory assay, western blot, and RT-PCR. An 86.7 % drop in BACE1 level was observed in the presence of the ECOI2 peptide. Though encouraging results were obtained from in-silico and in-vitro studies, more work is required to study the efficacy of these peptides in suitable animal models.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259276417,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2023.06.23.546343","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2023\/06\/24\/2023.06.23.546343.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"When one attempts to modulate and control the characteristics of composite materials, the mathematical threshold of the percolation transition dictates the modulation limit. Using a series of computer simulations, we have been investigating the dependence of the percolation threshold on particle size distributions. However, one of the other factors that can deeply affect percolation behavior, the design of lattice, is always fixed to simple square or cubic lattices. This report presents the first calculation of a percolation threshold in a 2D triangular lattice with binary size distributions of conductor particles. Although a small quantitative difference was found, the results qualitatively matched to the results already reported for 2D square lattices, thus confirming our previous finding: the introduction of large conductor particles increases the percolation threshold in 2D. [doi:10.2320\/matertrans.M2012029]","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":55945628,"openaccessinfo":{"externalids":{"MAG":"1977261780","ACL":null,"DOI":"10.2320\/MATERTRANS.M2012029","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This chapter reviews literature on probiotics. Probiotics are defined and different microbial cultures used as probiotics will be considered. It further discusses delivery vehicles for probiotic cultures, with their advantages and disadvantages. Since the presence of viable probiotic cultures in products is vital to their functionality, different methods used for their detection in products will be examined. The beneficial health effects of probiotics, the methods that are currently used in an attempt to overcome some of the challenges faced will also be discussed. Different strategies for protection of probiotic cultures and challenges for the probiotic industry are highlighted. In addition to these, alternative strategies increasing numbers of beneficial microorganisms through administration of prebiotics and synbiotics are briefly mentioned.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":129491494,"openaccessinfo":{"externalids":{"MAG":"1558443548","ACL":null,"DOI":"10.5772\/32889","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.intechopen.com\/citation-pdf-url\/35442","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The present study examines whether the daily rhythm of distal skin temperature (DST) is associated with brown adipose tissue (BAT) metabolism as determined by 18F-fluorodeoxyglucose (18F-FDG) uptake in young adults. Using a wireless thermometer (iButton) worn on the nondominant wrist, DST was measured in 77 subjects (26% male; age 22 \u00b1 2 years; body mass index 25.2 \u00b1 4.8 kg\/m2) for 7 consecutive days. The temperatures to which they were habitually exposed over the day were also recorded. The interday stability of DST was calculated from the collected data, along with the intraday variability and relative amplitude; the mean temperature of the 5 and 10 consecutive hours with the maximum and minimum DST values, respectively; and when these hours occurred. Following exposure to cold, BAT volume and mean and peak standardized 18F-FDG uptake (SUVmean and SUVpeak) were determined for each subject via static 18F-FDG positron emission tomography\/computed tomography scanning. Relative amplitude and the time at which the 10 consecutive hours of minimum DST values occurred were positively associated with BAT volume, SUVmean, and SUVpeak (p \u2264 0.02), whereas the mean DST of that period was inversely associated with the latter BAT variables (p \u2264 0.01). The interday stability and intraday variability of the DST were also associated (directly and inversely, respectively) with BAT SUVpeak (p \u2264 0.02 for both). All of these associations disappeared, however, when the analyses were adjusted for the ambient temperature to which the subjects were habitually exposed. Thus, the relationship between the daily rhythm of DST and BAT activity estimated by 18F-FDG uptake is masked by environmental and likely behavioral factors. Of note is that those participants exposed to the lowest ambient temperature showed 3 to 5 times more BAT volume and activity compared with subjects who were exposed to a warmer ambient temperature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":199469307,"openaccessinfo":{"externalids":{"MAG":"2966096849","ACL":null,"DOI":"10.1177\/0748730419865400","PubMedCentral":"6732824","ArXiv":null},"license":"CCBYNC","url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0748730419865400","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"DNA methylation is an epigenetic modification with a very long evolutionary history. However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome-wide distribution of methylation diversifies rapidly in different lineages, and DNA methylation is lost altogether surprisingly frequently. The growing availability of genomic and epigenomic sequencing across organisms highlights this diversity but also illuminates potential factors that could explain why both the DNA methylation machinery and its genome-wide distribution evolve so rapidly. Key to this are new discoveries about the fitness costs associated with DNA methylation, and new theories about how the fundamental biochemical mechanisms of DNA methylation introduction and maintenance could explain how new genome-wide patterns of methylation evolve.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248543842,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1042\/BST20210725","PubMedCentral":"9246332","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we propose a novel low-power Carry-Select Adder (CSA) design called Cascaded CSA (CSA). Based on the prediction of the critical path delay of current operation, CSA can automatically work with one or two clock-cycle latency and a scaled supply voltage to achieve power improvement. Post-layout simulations of a 64-bit CSA in 180nm Technology show that CSA can operate at a lower supply voltage, attaining 40.7% energy saving, while maintaining a similar (average) Latency Per Operation (LPO) compared to standard CSA.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":54815196,"openaccessinfo":{"externalids":{"MAG":"66243231","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"--- The recent pneumonia spread brought about by a novel corona virus (COVID-19) in china is representing an incredible risk and proclaimed a worldwide emergency of public health. It has spread to the world and infected people with COVID-19 disease. In addition to the absence of explicit treatment as well as vaccine, COVID-19 are currently known to reveal a noteworthy environmental resistance. The transmission of virus was found to be spread through human \u2013to \u2013 human that make it easily diffused. The transmission comes from the droplets of infected when sneezing or coughing. These droplets can survive on the inanimate surface even in air and transmitted the virus to human. The aim of our project is to design and develop an antiseptic disinfection spraying system has ability to disinfect large scale area with less time consuming and minimal human interactions. The range of drone is 100m and speed 8m\/s","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250648097,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The initial singularity is the most troubling feature of the standard cosmology, which quantum effects are hoped to resolve. In this paper, we study quantum cosmology with conformal (Weyl) invariant matter. We show it is natural to extend the scale factor to negative values, allowing a large, collapsing Universe to evolve across a quantum \"bounce\" into an expanding Universe like ours. We compute the Feynman propagator for Friedmann-Robertson-Walker backgrounds exactly, identifying curious pathologies in the case of curved (open or closed) universes. We then include anisotropies, fixing the operator ordering of the quantum Hamiltonian by imposing covariance under field redefinitions and again finding exact solutions. We show how complex classical solutions allow one to circumvent the singularity while maintaining the validity of the semiclassical approximation. The simplest isotropic universes sit on a critical boundary, beyond which there is qualitatively different behavior, with potential for instability. Additional scalars improve the theory's stability. Finally, we study the semiclassical propagation of inhomogeneous perturbations about the flat, isotropic case, at linear and nonlinear order, showing that, at least at this level, there is no particle production across the bounce. These results form the basis for a promising new approach to quantum cosmology and the resolution of the big bang singularity.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119373475,"openaccessinfo":{"externalids":{"MAG":"2561370183","ACL":null,"DOI":"10.1103\/PhysRevD.95.103510","PubMedCentral":null,"ArXiv":"1612.02792"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tournament water skiing is an increasingly popular and internationally successful sport in Great Britain, despite the climate. The kinematics and injury patterns of the three disciplines will be unfamiliar to most clinicians and are described, with estimation of the stresses. Advances in equipment over the last 15 years have reduced the risk of severe injury in the tricks event, while high speed impacts are responsible for the majority of trauma in slalom and jump. There is a surprisingly high incidence of injury to the lumbar spine during the high impact jump event. Comparison with findings in other sports suggests that the spine may be damaged by overuse, particularly before skeletal maturity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37469521,"openaccessinfo":{"externalids":{"MAG":"1995545425","ACL":null,"DOI":"10.1136\/bjsm.30.2.90","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/bjsm.bmj.com\/content\/bjsports\/30\/2\/90.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Objective: To compare the therapeutic effects of endovascular and open surgery on abdominal aortic aneurysms. \u00a0Methods: From June 2019 to May 2020, 60 cases of abdominal aortic aneurysms (AAA) were divided into observation group (30 cases in endovascular technique group) and control group (30 cases in open technique group). Results: The blood loss, operative time and blood transfusion of the observation group were significantly lower than those of the control group (P<0.05). The incidence of postoperative complications is low, and the incidence of long-term complications is relatively high. \u00a0Conclusion: In the treatment of abdominal aortic aneurysm, endovascular technology has the advantages of low risk, less trauma, and quick recovery after surgery. Open surgery is suitable for patients who cannot receive endovascular treatment. In order to achieve good treatment effects, it is necessary to choose an appropriate treatment method according to the actual situation of the patient.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":231674489,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.26689\/par.v4i6.1682","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.26689\/par.v4i6.1682","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"One-dimensional ZnO nanorods and nanowires are separately synthesized on Zn substrate by simple hydrothermal processes at low temperatures. Electro-catalytic responses of glucose oxidase\/ZnO\/Zn electrodes using these two synthesized nanostructures of ZnO are reported and compared with others available in literature. It is apparent the Michaelis\u2013Menten constant, K M app ?> , for the present ZnO nanowire, having a greater aspect ratio, is found to be the lowest when compared with others. This sensor shows lower oxidation peak potential with a long detection range of 6.6 \u03bcM\u2013380 mM and the highest sensitivity of \u223c35.1 \u03bcA cm\u22122 mM\u22121, among the reported values in the literature. Enzyme catalytic efficiency and turnover numbers are also found to be remarkably high.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2749469,"openaccessinfo":{"externalids":{"MAG":"2039228768","ACL":null,"DOI":"10.1088\/0957-4484\/24\/22\/225502","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper deals with the important problem of parameter estimation in the presence of bounded data uncertainties. Its recent closed-form solution leads to more meaningful results than alternative methods (e.g., total least-squares and robust estimation), when a priori bounds about the uncertainties are available. The derivation requires the computation of the SVD of the data matrix and the determination of the unique positive root of a nonlinear equation. This paper establishes the existence of a fundamental contraction mapping and uses this observation to propose an approximate recursive algorithm that avoids the need for explicit SVDs and for the solution of the nonlinear equation. Simulation results are included to demonstrate the good performance of the recursive scheme.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":17626803,"openaccessinfo":{"externalids":{"MAG":"1961103898","ACL":null,"DOI":"10.1109\/ICASSP.1997.604635","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"one of the important challenges in grid is quality of service (QoS) for all the accepted users or applications, while increasing the utilization of resources through resource sharing. An effective resource management approach must guarantee the QoS and balance the load among grid nodes which are frequently highly dynamic and heterogeneous. Grid resources are commonly varied regarding their software and hardware formations. Collecting and supervision of these resources, and discovering appropriate resources is an important topic. So semantic can be very useful for resource discovery and resource selection. Fuzzy theory is another intelligent approach which shows uncertainty in Phenomena. In this paper, a novel approach, which is using semantic and fuzzy theory, is proposed to discover grid resource in Grid environment. Search expressiveness, efficiency and scalability, precision and also discover more related resources are the characteristics of the proposed framework.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":61829629,"openaccessinfo":{"externalids":{"MAG":"2243188946","ACL":null,"DOI":"10.11113\/IJIC.V2N1.11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The HiSCORE detector, a new non-imaging wide-angle Air-Cherenkov ground based array, is currently in its engineering phase. Time synchronization to nsec-level between detector stations, distributed over 10-100km2, is essential to reach best angular resolution for high energy gamma rays. A dedicated time-synchronization and trigger time-stamping system has been developed, and is operating at the Tunka site since October 2012. The system is based on White Rabbit, a new synchronization standard using synchronous Gigabit Ethernet. This first White Rabbit application in a field setup confirms long-term operation with nsec clock precision and phase stability to sub-nsec level; the system is ready for use.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":165154950,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"O6-Methylguanine-DNA methyltransferase (MT) specific activity (fmol\/mg protein) was measured in human T lymphocytes which were maintained as exponentially growing cultures from 6 to 17 days. The T lymphocytes were not transformed and were grown under the same conditions used previously for determination of spontaneous human mutant frequencies. Although large inter-individual differences in activity were found, the differences were not attributable to donor age, sex or time in culture. The reported specific activity results, including the age and sex independence, were similar to other laboratories even though non-cultured peripheral blood T lymphocytes were previously used. Since cells from Alzheimer's disease (AD) patients have been shown to be overly sensitive to alkylation damage induced by N-methyl-N'-nitro-N-nitrosoguanine, and since no one has previously assayed MT activity in cells from AD patients, we compared MT activities in cultured T lymphocytes from AD patients, healthy controls and neurological controls. Similar levels of MT specific activity were found in each category analysed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30220403,"openaccessinfo":{"externalids":{"MAG":"2036290919","ACL":null,"DOI":"10.1093\/MUTAGE\/5.2.169","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Appointment of the Vacant Canons in the metropolitan chapter of Olomouc, according to the statutes of 1826, included the Metropolitan Chapter and the Emperor. This type of occupation was abolished by the new Code of Canon Law (1917) and in 1918 the monarchy ceased to exist. While at the time of the episcopate of Archbishop Stojan the controversy over the Appointment of Vacant Canons took place especially with the newly established Czechoslovak state, which had forfeited the privileges of the \"Habsburg Monarchy\". Stojan was able to appoint new Canons in 1923. His successor Leopold Precan also had to deal with the issue of vacant Canons as well as the question of the approval of the new statutes of the Olomouc metropolitan chapter, which would be in accordance with the new Code of Canon Law. While the appointment of the vacant canons was achieved in 1933 and 1938, the approval of the recalculated chapter statutes was not achieved until the end of his episcopate. Precan's successor, Archbishop Matocha, also called for the chapter to present revised statutes, but due to the emergence of the Communist totalitarian system in Czechoslovakia, it was not the appropriate time to approve the statutes. The capital statutes of 1826 thus applied until 1994, when new statutes were approved by Archbishop Jan Graubner, which were modified to be in accordance with the Code of Canon Law.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":204411419,"openaccessinfo":{"externalids":{"MAG":"2782207408","ACL":null,"DOI":"10.5507\/STH.2017.066","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"I read the article by Rubab et al. with considerable interest [1]. The study assessing self-esteem and depression in burn afflicted women should be regarded as an important aspect in the welfare of the patients and is commendable on what the study has tried to achieve in this aspect. The findings showed that depression is dependent on burn status, religion, age and marital status of the patient, whereas selfesteem is dependent on burn status. I would like to point out some points or suggestions, I noticed in methodology and term used in the article.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":212476632,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the conditions that favour boxiness of isodensities in the face-on views of orbital 3D models for barred galaxies. Using orbital weighted profiles we show that boxiness is in general a composite effect that appears when one considers stable orbits belonging to several families of periodic orbits. 3D orbits that are introduced due to vertical instabilities play a crucial role in the face-on profiles and enhance their rectangularity. This happens because at the 4:1 radial resonance region we have several orbits with boxy face-on projections, instead of a few rectangular-like x1 orbits, which, in a fair fraction of the models studied so far, are unstable in this region. Massive bars are characterized by rectangular-like orbits. However, we find that it is the pattern speed that affects the elongation of the boxy feature most, in the sense that fast bars are more elongated than slow ones. Boxiness in intermediate distances between the centre of the model and the end of the bar can be attributed to x1v1 orbits, or to a combination of families related to the radial 3:1 resonance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":14328624,"openaccessinfo":{"externalids":{"MAG":"2131216930","ACL":null,"DOI":"10.1046\/j.1365-8711.2003.06511.x","PubMedCentral":null,"ArXiv":"astro-ph\/0302198"},"license":null,"url":"https:\/\/academic.oup.com\/mnras\/article-pdf\/342\/1\/69\/3590357\/342-1-69.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"While just over one in three heterosexual women will experience intimate partner violence (IPV) in her lifetime, 61% of bisexual women and 78% of non-monosexual women will. Combining previous research and theories on power, social resources, binegativity, and gender-based violence, this article analyzes the role of power and inequality in non-monosexual women's IPV victimization. Using data from the National Intimate Partner and Sexual Violence Survey, this article first examines rates of IPV victimization for statistically significant differences between monosexual (e.g., only have dating, romantic, and sexual partners of one sex\/gender) and non-monosexual (e.g., have dating, romantic, and sexual partners of multiple sexes\/genders) women in the United States and, second, introduces theoretically important variables to logistic regression analyses to determine the correlates of IPV victimization among non-monosexual women (age, race ethnicity, income, education, immigration status, and indigeneity; partner gender; sexual identity). Findings indicate that non-monosexual women are more likely to experience sexual, emotional, and psychological\/control violence, and intimate stalking, but have an equivalent risk of experiencing physical violence. Moreover, having an abusive partner who is a man, having a lot of relative social power, and self-identifying as \"bisexual\" are all significant factors in violence victimization. Importantly, this is the first study using nationally representative data that confirms non-monosexual women are particularly at risk for sexual identity-based violence at the hands of their male\/man partners, suggesting binegativity and biphobia may indeed be linked to hegemonic masculinity. Suggestions for moving research forward include improving data collection efforts such that we can disentangle gender from sex and individual aggregate power from relationship inequalities, as well as more adequately account for the timing of sexual identity disclosures within relationships, relative to the timing of violent episodes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":809650,"openaccessinfo":{"externalids":{"MAG":"2751214824","ACL":null,"DOI":"10.1177\/0886260517726415","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug\/polymer ratio, stirring rate and type of polymer on the mean particle size, drug entrapment efficiency, yield, drug content, micromeritic properties and drug release of the microspheres were studied. Results: It was observed that as the stirring speed increased from 600 to 1800 rpm, microsphere size decreased and hence drug release rate increased. Drug release rate at 1:2 drug: polymer for microspheres produced at a stirring rate of 1200 rpm was in the following order: carbopol 934P > HPMC > ethyl cellulose > chitosan. The formulations containing carbopol 934P (CA3) and HPMC (HPMC3) released drug faster than chitosan microspheres (CH3).\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Conclusion: Amongst the developed microspheres, CH3 formulation (with chitosan as the polymer) exhibited maximum prolonged drug release at gastrointestinal pH or at least 15 h. This oral sustained metformin formulation could potentially improve the bioavailability of the drug as well as patient compliance. Keywords: Metformin, Microspheres, Prolonged release, Solvent evaporation, Ethylcellulose, Hydroxypropyl methylcellulose, Chitosan","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":10501605,"openaccessinfo":{"externalids":{"MAG":"2124939196","ACL":null,"DOI":"10.4314\/TJPR.V11I4.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Asparagine potentiates the growth-promoting effect of bovine growth hormone in rats when injected 3h after the latter, but not earlier. Tryptophan potentiates only when injected simultaneously with the hormone. The possible mode of action of growth hormone, and the likelihood that asparagine is a limiting factor in the growth of animals, are discussed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":19191997,"openaccessinfo":{"externalids":{"MAG":"2345799777","ACL":null,"DOI":"10.1042\/BJ1360441","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study homogeneous, independent percolation on general quasi-transitive graphs. We prove that in the disorder regime where all clusters are nite almost surely, in fact the expectation of the cluster size is nite. This extends a well-known theorem by Menshikov and Aizenman & Barsky to all quasi-transitive graphs. Moreover we deduce that in this disorder regime the cluster size distribution decays exponentially, extending a result of Aizenman & Newman. Our results apply to both edge and site percolation, as well as long range (edge) percolation. The proof is based on a modication of the Aizenman & Barsky method.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":124929347,"openaccessinfo":{"externalids":{"MAG":"2336217962","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Ectopic thyroid tissue, 90% presenting in lingual zone, is often scanned by ultra-sonography or computed tomography. Most surgeons regard ectopic thyroid as metastatic foci from thyroid cancer, thus resection is recommended. Here, we reported a man with bilateral papillary thyroid cancer, accompany with normal ectopic thyroid tissue in right sternocleidomastoid muscle. In this case, we highlighted: (i) It is rarely reported that ectopic normal thyroid tissue presented in sternocleidomastoid muscle. (ii) The ectopic thyroid tissue may not always be metastatic foci even though bilateral thyroid tumors were confirmed to be papillary cancer. (iii) Contrary to radical excision of all ectopic thyroid tissue, we advocate that only patients who need to receive the radioactive iodine therapy after total thyroidectomy should remove the ectopic normal thyroid tissue.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245702205,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/jscr\/rjab578","PubMedCentral":"8711861","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1093\/jscr\/rjab578","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Local authorities were involved in Further Education (FE) from 1889 to 1993, but it was not until 1944 that LEAs were obliged to provide facilities for FE. This study considered economic, political and social factors when examining changes in the roles of central and local government and other policy changes. Such factors included national economic policies, recessions, two World Wars, and changes in dominant political views. Policy changes and local implementation were examined by analysing contemporary national and local documents. The Local Education Authority (LEA) chosen for investigation in this study was Worcestershire which, after the reorganisation of local government in 1974, joined Herefordshire and the County Borough of Worcester to become the County of Hereford and Worcester. The Worcestershire FE College selected was Redditch College, which merged with North Worcestershire College in 1988 to form North East Worcestershire College. \nChanges in the relationship between central and local government were brought about by legislation and from 1964 by the introduction of agencies, such as the Manpower Services Commission. These agencies were established as one way of increasing the number of skilled workers. However, they also reduced the LEAs\" control of FE, because they had to approve some FE college courses and provided funding. The advent of the Audit Commission in the mid-1980s further reduced the LEAs\" control of the FE sector and ensured LEAs focused more closely on efficiency measures than they had previously. Legislation in 1968 and 1988 reduced the proportion of governors who could be LEA representatives. The movement away from local control exercised by elected politicians meant that central government had greater control over the implementation of FE policy. From the 1980s the Conservative Government\"s policy included developing a quasi-market in FE, while from the mid-1980s a new business discourse was found in both national and local FE documents. \nSince the 1860s governments have frequently regarded an inadequately skilled workforce as the reason for Britain becoming less economically competitive. One solution offered was raising the school leaving age, so that more pupils would be able to benefit from a scientific or technical education. It took from 1918 to 1972 for the school leaving age to be raised from 14 to 16. Compulsory part-time day courses for school leavers until they were 18 were proposed in 1918, and also recommended in 1943 and 1959, but they did not materialise. With the constant decline of manufacturing, fewer unskilled jobs and the increased complexity of skills required, the 2008 Education and Skills Act planned that by 2015 16 and 17 year olds would have to undertake some form of education or training until they are 18. The analysis in this study suggested some of the problems that might be encountered. While there was government exhortation for a more qualified workforce, there was less enthusiasm for making it compulsory that FE lecturers should have a teaching qualification. Some explanations were offered for this state of affairs until 2001.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":154917400,"openaccessinfo":{"externalids":{"MAG":"2209215357","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Murine monoclonal antibodies (MoAbs) directed against DAF (Decay Accelerating Factor, CD55 antigen) and MIRL (Membrane Inhibitor of Reactive Lysis, CD59 antigen) were used to identify the affected red cells (CD55-\/CD59-) of PNH patients. MoAbs NaM16-4D3 (CD55, IgG2a) and NaM77-1E5 (CD59, IgG3) weakly agglutinate red cells and represent powerful tools to quantitate normal (PNHI) and abnormal (PNHII and PNHIII) cells from PNH patients by indirect flow cytometry. MoAbs NaM125-7H10 (CD55) and NaM123-6G12 (CD59), both IgM, were selected for their agglutinating properties and used for the separation of PNHI from PNHII and PNHIII red cells by the gel test technology. From analysis of artificial mixtures of DAF+ and DAF- cells, a direct relationship was established between fluorescent cells detected by flow cytometry, and erythrocytes agglutinated in microtyping cards. The method was further confirmed by analysis of ten blood samples from PHN patients and represent an alternative to classical hemolysis tests. On the basis of our experience we propose the following for the diagnosis of PNH: 1) agglutination test with NaCl microtyping cards using IgM CD55 and CD59; 2) flow cytometry analysis for accurate quantitation of CD55-\/CD59- red cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6073031,"openaccessinfo":{"externalids":{"MAG":"2395778609","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel vesicle, referred to as a precursor-accumulating (PAC) vesicle, mediates the transport of storage protein precursors to protein storage vacuoles in maturing pumpkin seeds. PV72, a type I integral membrane protein with three repeats of epidermal growth factor, was found on the membrane of the PAC vesicles. PV72 had an ability to bind to pro2S albumin, a storage protein precursor, in a Ca(2+)-dependent manner, via the C-terminal region of pro2S albumin, which was found to function as a vacuolar targeting signal. This implies that PV72 is a vacuolar sorting receptor of the storage protein. PV72 was specifically and transiently accumulated at the middle stage of seed maturation in association with the synthesis of storage proteins. Subcellular fractionation showed that PV72 was also accumulated in the microsomal fraction. A fusion protein consisting of GFP and the transmembrane domain and the cytosolic tail of PV72 was localized in Golgi complex. PV72 in the isolated PAC vesicles had a complex type of oligosaccharide, indicating that PV72 passed though the Golgi complex. These results suggest that PV72 is recycled between PAC vesicles and Golgi complex\/post-Golgi compartments. PV72 appears to be responsible for recruiting pro2S albumin molecules from the Golgi complex to the PAC vesicles.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22448012,"openaccessinfo":{"externalids":{"MAG":"1963980596","ACL":null,"DOI":"10.1093\/PCP\/PCF152","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For the past few years, poor safety records in the conventional civil construction industry has tarnished its reputation and image. In addition to that, better safety management and practices in the oil and gas construction industry as compared to conventional civil construction industry are primely due to contractual requirements and consistent drives by the clients\/project owners. Hence, the aim of this study is to justify best safety practices in the oil and gas construction industry that can be adopted for the conventional civil construction industry. A total of 100 sets of questionnaire were prepared and distributed to targeted respondents from construction companies ranging from CIDB Grade G1 to G7 around localised areas such as Johor Bahru, Kuala Lumpur and part of Selangor. The feedbacks from 83 respondents were analysed using frequency and relative index analysis. Based on the survey findings, it shows an excellent trend in basic practices of construction safety management. Conversely, it shows very low commitment and concern on the importance of ERT in handling emergency situations. Finally, only 52.61% (slightly more than half) of the surveyed safety management practices implemented in the conventional civil construction industry. Overally the respondents' perceptions are in the 'agree' and 'strongly agree' categories for the levels of key elements surveyed. Whereas they perceived '5-Excellent' and only '3-Good' for levels of overall safety management and practices in oil and gas and conventional civil construction industries respectively. The six (6) interview respondents have also given the similar ratings. There is a strong need for the company management to implement the improvement measures in order to further improve the construction safety management. The respondents also tend to 'strongly agree' that implementing all the proposed measures can improve the construction safety management, safety investment is a viable and worthy effort and safety indicators implementation is low. Among recommended safety best practices are guiding policies, certifications, good HSE plannings, programs, rules and practices, safety indicators and safety campaigns and celebrations.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":113199422,"openaccessinfo":{"externalids":{"MAG":"2270504738","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Depression is much more than just tiredness or unpleasantness for a few days. Some individuals believe that depression is a minor ailment rather than a serious medical disease. However, depression is not a weakness that can be \"snapped out of\" by \"getting yourself together.\" Depression is a disease which can be recovered by taking proper treatment and support. Depression symptom may be easily detected when a man or woman goes into depression. For the purpose of medication and assistance purpose, prediction of prognosis of the depression is important. In this research paper, five Machine Learning algorithms such as Decision Tree Classifier (DTC), Random Forest Classifier (RFC), Multi-layer Perceptron Classifier (MLP), Support Vector Machine (SVM), and AdaBoost Classifier are used to apply to for prediction of depression prognosis. As a result, it is found that SVM machine learning algorithm performs the best. It has an accuracy rate of 85 percent. Also indicated is the age at which men and women are most likely to become depressed. Support Vector Machine classifiers also have low FP (False Positive) and FN (False Negative) rates. Some visualization is applied to generate a view of depression rate in different types of people. This study also used principal component analysis to Figure out the selective data for analysis algorithms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":247795251,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ICAIS53314.2022.9742757","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A report is given of the results of investigations of electronic-vibrational spectra of chlorophyll molecules and their analogs, embedded in solid-state matrices, which were carried out using modern selective spectroscopic methods such as laser monochromatic excitation of the fluorescence and spectral hole burning. The fundamentals of the application of these methods to complex impurity molecules are considered together with the problems encountered in the analysis of the structure of the selective spectra, mechanisms of the appearance of stable and dynamic spectral holes, and determination of homogeneous spectral profiles and relaxation times. Special attention is given to a theory of the appearance of zero-phonon lines under energy transfer conditions and experimental detection of these lines in model and native systems.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":118777410,"openaccessinfo":{"externalids":{"MAG":"2110198118","ACL":null,"DOI":"10.1070\/PU1988V031N03ABEH005718","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, micro dried bio-potential electrodes are demonstrated for sEMG (surface ElectroMyoGraphic) signal measurement using conductive epoxy on the textile fabric. Micro dried bio-potential electrodes on the textile fabric substrate have several advantages over the conventional wet\/dry electrodes such as good feeling of wearing, possibility of extended-wearing due to the good ventilation. Also these electrodes on the textile fabric can easily apply to the curved skin surface. These electrodes are fabricated by the screen-printing process with the size of and the resultant resistance of these electrodes have the average value of . The conventional silver chloride electrode shows the average value of . However, the electrode on the textile fabric are able to measure the sEMG signal without feeling of difference and this electrode shows the lower resistance of than conventional silver chloride electrode with in the condition of the very sharp curve surface (the radius of curvature is 40 mm).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":135759566,"openaccessinfo":{"externalids":{"MAG":"1999671219","ACL":null,"DOI":"10.4313\/JKEM.2013.26.5.367","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A hexagonally ordered mesoporous carbon, CMK-3, was utilized as a support for a Fischer-Tropsch catalyst. Each array of elongated pore structures with Co nanoparticles can be regarded as a nanochannel reactor. Due to the pore confinement and the hydrophobic nature of the support, this catalyst demonstrated excellent catalytic performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205834652,"openaccessinfo":{"externalids":{"MAG":"2031479741","ACL":null,"DOI":"10.1039\/c3cc00297g","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/oasis.postech.ac.kr\/bitstream\/2014.oak\/10025\/1\/OAIR000753.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Recently, there has been an explosion of information concerning bacterial-epithelial cell interactions. These studies have revealed various mechanisms by which bacterial pathogens exploit host cell machinery to their own advantage and have demonstrated that pathogenic organisms can interfere with the pathways that regulate barrier function, one of the basic properties of epithelia.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":86116387,"openaccessinfo":{"externalids":{"MAG":"2147713505","ACL":null,"DOI":"10.1152\/PHYSIOLOGYONLINE.1995.10.4.160","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the increase in the global population observed since the 20th century, urban centers are becoming more prominent, and its dynamic is now far from the natural. The impact of urbanization on the rainfall has been noticed since 1921 when Horton observed that cities with more than 100,000 inhabitants created favorable conditions for convective precipitation. Later, Huff and Changnon (1972) estimated an increase of 6 to 15% on average rainfall during the summer in these regions. Several other studies confirmed the trend and pointed out that on a small and medium scale, precipitation change is usually justified by the effect of heat islands. To understand these changes, high-resolution precipitation data is needed; however, due to the lack of monitored data, especially on the largest cities in the developing countries, new sources of information should be used. MSWEP is a three hourly gridded precipitation dataset, with 0.1o spatial resolution that combines data from gauges, satellite, and reanalysis-based data to provide precipitation estimates over the entire globe (Beck, 2019). In this study, MSWEP precipitation was used in order to observe the variability of intense precipitation over the Metropolitan Area of Porto Alegre in Southern Brazil, where some previous studies indicated urban effects on precipitation. Statistical analysis was performed to evaluate changes in the intense precipitation throughout the decades. The results show that the spatial distribution patterns of intense precipitation are maintained; however, in all statistics, it was possible to observe an increase in intense precipitation over the decades, that follows the increase of the urbanized area over time.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":224387371,"openaccessinfo":{"externalids":{"MAG":"3091518682","ACL":null,"DOI":"10.5194\/egusphere-egu2020-12716","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A graph is a circular arc graph if each vertex of the graph is associated with an arc on a circle in such a way that two vertices of the graph are adjacent if and only if the corresponding arcs overlap. A circular arc graph is proper if none of the representing arcs is contained within another. An O(n 2) algorithm is given for determining whether a proper circular arc graph with n nodes may be colored with k colors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15554858,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on the Swarm platform and adaptive multi-agents of complex system, the simulation model of mobile telecommunications market's regulation has been developed with the aim to simulate the effects of regulatory policies. Through the different simulation results, the implementation of regulatory policies having impact on the mobile telecommunications market can be analyzed, which provides theoretical support and basis for the future development of mobile telecommunications market's regulatory policy, in order to avoid the unpredictable and potential risk of the regulatory policies in the effective implementation process.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108635081,"openaccessinfo":{"externalids":{"MAG":"1985604456","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMM.556-562.5417","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": We present vertex operators for ambitwistor strings around generic Yang-Mills, gravity and NS-NS backgrounds. The requirement that vertex operators lie in the BRST cohomology of the worldsheet theory enforces the appropriate linear equations of motion (as well as gauge fixing conditions) for the respective perturbations in these backgrounds. Due to the nature of ambitwistor strings, no approximation is taken and all calculations around the backgrounds are exact.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251800852,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel continuous camera calibration algorithm is proposed, which can address the calibration for non-goal area of soccer video. By considering the fact that the position of main camera is stable, a novel continuous camera calibration algorithm is proposed for soccer video analysis. There are two stages for calibration: the first stage addresses the calibration only for goal area and the position of camera is computed and recorded, and then the second stage can address calibration for any area including non-goal area where the camera position is given at first stage. Thus, the proposed algorithm can address the calibration for non-goal area of soccer video, which cannot be addressed by traditional calibration algorithms since the inadequate of calibration objects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":131474253,"openaccessinfo":{"externalids":{"MAG":"2188730824","ACL":null,"DOI":"10.14257\/IJUNESST.2015.8.3.08","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the quadratic bottleneck problem (QBP) which generalizes several well\u2010studied optimization problems. A weak duality theorem is introduced along with a general purpose algorithm to solve QBP. An example is given which illustrates duality gap in the weak duality theorem. It is shown that the special case of QBP where feasible solutions are subsets of a finite set having the same cardinality is NP\u2010hard. Likewise the quadratic bottleneck spanning tree problem (QBST) is shown to be NP\u2010hard on a bipartite graph even if the cost function takes 0\u20131 values only. Two lower bounds for QBST are derived and compared. Efficient heuristic algorithms are presented for QBST along with computational results. When the cost function is decomposable, we show that QBP is solvable in polynomial time whenever an associated linear bottleneck problem can be solved in polynomial time. As a consequence, QBP with feasible solutions form spanning trees, s\u2010t paths, matchings, etc., of a graph are solvable in polynomial time with a decomposable cost function. We also show that QBP can be formulated as a quadratic minsum problem and establish some asymptotic results. \u00a9 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":122617797,"openaccessinfo":{"externalids":{"MAG":"2081756636","ACL":null,"DOI":"10.1002\/nav.20446","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The present study was carried out with the objective of evaluating the effect of artificial pollination and gibberellic acid (GA3 ) in different doses and times of application in the fruit set, effective fruiting and the quality of 'Gefner' atemoieira fruits. The experimental design was in randomized blocks, with thirteen treatments, four replicates and five plants per plot. The treatments applied were different doses of GA3 : 100, 150, 200, 250, 500 and 1000 mg L-1 associated or not with artificial pollination. It was evaluated every seven days the fruit set, length and diameter of the fruits, and after the harvest the physical and chemical characteristics of the fruits. The growth rate of fruit length and diameter showed a sigmoid pattern with the highest growth peaks in all treatments at the 4th and 5th weeks after the anthesis. The application of 1000 mg L-1 GA3 , without artificial pollination, divided in four times from the anthesis yielded seedless fruits with physical and chemical quality equivalent to the fruits of artificial pollination. The artificial pollination associated to two applications of 250 mg L-1 of GA3 showed high fruit set and fruits with greater length, diameter, mass of the fruits and reduction of the total fresh mass of the seeds.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":92300622,"openaccessinfo":{"externalids":{"MAG":"2920722509","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of industrial waste and\/or by-products as alternative sources of raw materials in building materials has become standard practice. The result, more sustainable construction, is contributing to the institution of a circular economy. Nonetheless, all necessary precautions must be taken to ensure that the inclusion and use of such materials entail no new health hazard for people or their environment. Due to the processes involved in generating industrial waste\/by-products, these alternative or secondary materials may be contaminated with heavy metals, other undesirable chemicals or high levels of natural radioactivity that may constrain their use. In-depth and realistic research on such industrial waste is consequently requisite to its deployment in building materials. This paper reviews the basic concepts associated with radioactivity and natural radioactivity, focusing on industrial waste\/by-products comprising Naturally Occurring Radioactive Materials (NORM) used in cement and concrete manufacture. Updated radiological data are furnished on such waste (including plant fly ash, iron and steel mill slag, bauxite and phosphogypsum waste) and on other materials such as limestone, gypsum and so on. The paper also presents recent findings on radionuclide activity concentrations in Portland cements and concretes not bearing NORMs. The role of natural aggregate in end concrete radiological behaviour is broached. The radiological behaviour of alternative non-portland cements and concretes, such as alkali-activated materials and geopolymers, is also addressed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238653214,"openaccessinfo":{"externalids":{"MAG":"3195169372","ACL":null,"DOI":"10.3989\/mc.2021.13520","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/materconstrucc.revistas.csic.es\/index.php\/materconstrucc\/article\/download\/2329\/3165","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important in order to help diagnostic accuracy and provide prognostic information about coronary cardiac disease. In acute coronary syndromes and percutaneous coronary intervention, elevated levels of almost all subtypes of white blood cell counts, including eosinophils, monocytes, neutrophils, and lymphocytes, and neutrophil\u2013lymphocyte ratio and eosinophil\u2013leukocyte ratio constitute independent predictors of adverse outcomes. Eosinophil count and eosinophil\u2013leukocyte ratio, in particular, emerge as novel biomarkers for risk stratification in patients with coronary artery disease. Since the presence of eosinophils denotes hypersensitivity inflammation and hypersensitivity associated with Kounis syndrome, this reality is essential for elucidating the etiology of inflammation in order to consider predictive and preventive measures and to apply the appropriate therapeutic methods.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7169114,"openaccessinfo":{"externalids":{"MAG":"2129306023","ACL":null,"DOI":"10.1177\/1076029614531449","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1076029614531449","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo determine whether anti-Giardia lamblia secretory IgA (sIgA) antibodies in human milk protect infants from acquisition of or symptoms associated with Giardia infection.\n\n\nMETHODS\nOne hundred ninety-seven Mexican mother\/infant pairs were followed weekly from birth for diarrheal disease and feeding status. Infant stool specimens were collected weekly and were cultured for bacterial pathogens and tested for Giardia and rotavirus by enzyme-linked immunosorbent assay. Maternal milk samples were collected weekly for 1 month postpartum and monthly thereafter. To determine the protective effect of anti-Giardia sIgA in milk against infection and against diarrhea due to Giardia, milk samples from mothers of infected infants and appropriately matched controls were assayed for anti-Giardia sIgA by enzyme-linked immunosorbent assay.\n\n\nRESULTS\nAsymptomatic, infected infants ingested significantly (P = .046) higher amounts of milk anti-Giardia sIgA compared with symptomatic, infected infants. However, milk anti-Giardia sIgA concentrations did not differ between Giardia-infected and noninfected infants.\n\n\nCONCLUSION\nThe amount of anti-Giardia sIgA in human milk was associated with prevention of symptoms of diarrhea due to Giardia, but not with acquisition of the organism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19394199,"openaccessinfo":{"externalids":{"MAG":"1581336773","ACL":null,"DOI":"10.1542\/peds.93.1.28","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Density functional theory calculations have been performed on the active species (Compound I) of cytochrome c peroxidase (CcP) and ascorbate peroxidase (APX) models. We have calculated a large model containing oxo-iron porphyrin plus a hydrogen-bonded network of the axial bound imidazole ligand connected to an acetic acid and an indole group, which mimic the His(175), Asp(235), and Trp(191) amino acids in cytochrome c peroxidase. Our optimized geometries are in good agreement with X-ray and crystallographic structures and give an electronic ground state in agreement with EPR and ENDOR results. We show that the quartet-doublet state ordering and the charge distribution within the model are dependent on small external perturbations. In particular, a single point charge at a distance of 8.7 A is shown to cause delocalization of the charge and radical characters within the model, thereby creating either a pure porphyrin cation radical state or a tryptophan cation radical state. Thus, our calculations show that small external perturbations are sufficient to change the electronic state of the active species and subsequently its catalytic properties. Similar effects are possible with the addition of an electric field strength along a specific coordination axis of the system. The differences between the electronic ground states of CcP and APX Cpd I are analyzed on the basis of external perturbations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21929138,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/jp053873u.s001","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/figshare.com\/articles\/journal_contribution\/What_Affects_the_Quartet_Doublet_Energy_Splitting_in_Peroxidase_Enzymes_\/3252880\/1\/files\/5088247.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The term g-government, a subset of e-government, was first introduced in 2000 as the convergence of geographical information systems (GIS) and the Internet to create more effective government interaction with citizens. More recently, it has been revised to describe the combination of GIS and Web 2.0 technologies that can enhance government services and delivery. Most government data is spatially based and can be visualised and interpreted using a Web GIS mapping application, but this data is often not available to other government departments, or the general public, frustratingly so.\nIn South Africa, problems with accessing spatial data continue to exist. The Gauteng City-Region Observatory (GCRO) recognised that g-government remains a challenge within the Gauteng city-region (GCR), and in 2010 developed a GIS website for the GCRO and Gauteng Provincial Government. This article is presented in the context of the global shift to fully connected governments through technologies such as Government 2.0 and g-government. It provides a specific focus on the GCRO GIS website and how it enables g-government by providing local and provincial government with the spatial data and tools required to better understand the city-region, and to make informed decisions about future development in the city-region. The article also reviews Technology Acceptance Model (TAM) scores measured at the launch of the website. Finally, monthly website visits are examined. This confirms that local and provincial government are ready to utilise the g-government website.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":130273874,"openaccessinfo":{"externalids":{"MAG":"1562123917","ACL":null,"DOI":"10.23962\/10539\/19709","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/journals.co.za\/doi\/pdf\/10.10520\/EJC134068","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Developing coordinated motor control is essential for competent interactions with the surrounding world and requires a balanced multisensory integration. This integration can be challenged under altered sensory feedback, as is the case for vision in immersive virtual reality (VR). While recent works suggest that a virtual sensory environment alters visuomotor integration in healthy adults, little is known about the effects on younger individuals. Here, we assessed the development of head-trunk coordination in children aged 6 to 10 years and young adults using an immersive flight simulator and a virtual joint angle reproduction task. Contrarily to previous results, when vision was decoupled from the steering body part, only older children and adults displayed a joint ('en-bloc') head-torso operation mode. Our results reveal that immersive VR affects the coordination strategy in younger children and highlight the immaturity of postural control through the inability to implement a simplified coordination strategy. These findings have implications for pediatric applications of immersive VR, and reveal its usability as an investigation tool for sensorimotor maturation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":224817980,"openaccessinfo":{"externalids":{"MAG":"3092878390","ACL":null,"DOI":"10.1101\/2020.10.14.338749","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1101\/2020.10.14.338749","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background Astrocytoma is the most common primary tumor of the brain. High-grade astrocytomas are aggressive tumors with poor prognosis. Biomarkers that predict patient outcome and response to a specific treatment will provide patients with personalized estimation of prognosis and customized therapeutic regimens with maximal effectiveness and minimal toxicity. Aim The aim of this work was to explore the ability of the expression of IDH1 R132H, pSTAT3, and Tbx2 proteins to predict outcome of patients with high-grade astrocytoma. Materials and methods The expression of IDH1 R132H, pSTAT3, and Tbx2 proteins was assessed by immunohistochemistry in 41 high-grade astrocytoma cases. They were correlated with patients' clinicopathological features, recurrence-free survival, overall survival (OS), and response to therapy. Results A significant direct association was observed between IDH1 R132H immunoreactivity and response to TMZ therapy (P=0.01), better progression-free survival (PFS) as well as OS (P<0.001). The expression of both Tbx2 and pSTAT3 proteins was inversely correlated with response to TMZ therapy (P=0.019 and 0.014, respectively). Survival analysis revealed that Tbx2 and pSTAT3 immunoreactivity was significantly associated with shorter PFS (P=0.021 and 0.047, respectively), as well as poor OS (P=0.005 and 0.007, respectively). Conclusion IDH1 R132H protein expression and loss of Tbx2 and pSTAT3 proteins are associated with prolonged PFS and OS and better response to TMZ chemotherapy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":80521374,"openaccessinfo":{"externalids":{"MAG":"2793440769","ACL":null,"DOI":"10.1097\/01.XEJ.0000526550.33535","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Ticks are hematophagous arthropods which normally attach to the surface of the skin of the host for the blood meal. Their aberrant presence in the subcutaneous tissue of few carnivores, predominantly foxes has been reported. However, there are no reports in other carnivores such as mustelids or golden jackals. Our aim was to investigate and broaden the host spectrum for this aberrant localization of ticks.Methods: Between 2015 and 2020, 198 carnivore carcasses from 12 species have been examined by parasitological necropsy. If subcutaneous ticks were found, the nodules were removed, carefully dissected, and stored in ethanol. The identification of the subcutaneous ticks was carried out at the species level.Results: A single subcutaneous tick was found in one sample, a golden jackal and was identified as a female Ixodes ricinus. All other carcasses were negative for subcutaneous ticks.Conclusion: The present paper represents the first report of a subcutaneous tick in a golden jackal (Canis aureus), extends the host spectrum of this unusual phenomenon and demonstrates to date its presence only in canid carnivores.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":243014430,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-50745\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-50745\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This study was carried out to assess the time course of pulmonary clearance impairment and persistence of inflammation following high-dose inhalation exposures to titanium dioxide (TiO2) or carbonyl iron (CI) particles. Male rats were exposed to air, TiO2 or CI particles 6 hr\/day, 5 days\/week, for 4 weeks at concentrations of 5, 50, and 250 mg\/m3 and evaluated at selected intervals through 6 months postexposure. Indices of pulmonary inflammation as well as alveolar macrophage clearance functions (i.e., morphology, in vivo and in vitro phagocytosis, and chemotaxis), cell proliferation, and histopathology endpoints were measured at several postexposure time periods through 6 months. In addition, amounts of TiO2 or CI in lungs and tracheobronchial lymph nodes were measured to allow an evaluation of particle clearance and translocation patterns. Four-week exposures to TiO2 or CI particles at concentrations of 250 mg\/m3 resulted in lung burdens of 12 mg titanium and 17 mg iron, respectively, with particle retention half-times ranging from 68 days for 5 mg\/m3 TiO2 to approximately 330 days for 250 mg\/m3. The impact of this TiO2 dust load and similar lung burdens of CI particles produced a sustained pulmonary inflammatory response measured through a period of 3-6 months postexposure concomitant with increases in BrdU cell labeling of terminal airway and pulmonary parenchymal cells. The impairment of particle clearance mechanisms was accounted for by deficits in in vitro phagocytic and chemotactic potential of alveolar macrophages recovered from the lungs of high-dose, TiO2- or CI-exposed rats. Free granular pigment (TiO2 or CI) was present on the hypertrophic mucosal surfaces of bronchioles and bronchi, and particle-laden macrophages, found individually, were numerous throughout alveoli and within lymphoid tissues immediately after exposure. Aggregates of particle-laden macrophages were present within alveoli and alveolar ducts from 1 week postexposure through the entire 6-month recovery period. Macrophage accumulations increased in size and number from 1 week through 1 month postexposure and then appeared to remain constant through the remaining 5-month postexposure period. Minimal cellular hypertrophy and hyperplasia were evident at alveolar duct bifurcations adjacent to macrophage aggregates, and this effect was most prominent at 3 to 6 months postexposure. The results of this study clearly demonstrate that exposure to high dust concentrations of two different innocuous particle types produced sustained pulmonary inflammation, enhanced proliferation of pulmonary cells, impairment of particle clearance, deficits in macrophage function, and the appearance of macrophage aggregates at sites of particle deposition. In addition, the mass deposition rate determination appears to be a less sensitive indicator of \"overload\" when compared to biomarkers of pulmonary toxicity, such as macrophage function and cellular inflammation and proliferation indices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36337761,"openaccessinfo":{"externalids":{"MAG":"1996838083","ACL":null,"DOI":"10.1006\/TAAP.1997.8102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An analytical approximation is developed for purely conductive heat transfer from impermeable blocks of rock to fluids sweeping past the rocks in fractures. The method was incorporated into a multi-phase fluid and heat flow simulator. Comparison with exact analytical solutions and with simulations using a multiple interacting continua approach shows very good accuracy, with no increase in computing time compared to porous medium simulations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":128451585,"openaccessinfo":{"externalids":{"MAG":"1549561733","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The idea of pushing computation to storage devices has been explored for decades, without widespread adoption so far. The definition of Computational Programs namespaces in NVMe (TP 4091) might be a breakthrough. The proposal defines device-specific programs, that are installed statically, and downloadable programs, offloaded from a host at run-time using eBPF. In this paper, we present the design and implementation of Delilah, the first public description of an actual computational storage device supporting eBPF-based code offload. We conduct experiments to evaluate the overhead of eBPF function execution in Delilah, and to explore design options. This study constitutes a baseline for future work.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1,"unknown":2}},"corpusid":259149408,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1145\/3592980.3595319","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3592980.3595319","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of \u03bc1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208436518,"openaccessinfo":{"externalids":{"MAG":"2980088972","ACL":null,"DOI":"10.17650\/1726-9776-2019-15-3-42-45","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.17650\/1726-9776-2019-15-3-42-45","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The temperature dependences of the intensities of the second and composite optical harmonics of lines (\u03bb = 510.5 and 578.2 nm) emitted by a copper vapour laser were determined. The harmonics were generated in crystals of ferroelectric sodium nitrite. The dependences were affected significantly by the excitation conditions. The observed effects were attributed to the characteristics of the phase state of the surface layers of the ferroelectric.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":117029517,"openaccessinfo":{"externalids":{"MAG":"229231500","ACL":null,"DOI":"10.1070\/QE1994V024N04ABEH000087","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Palearctic staphylinid beetles of the subfamily Aleocharinae occuring in North America are discussed. The record of Meotica exilis (Knoch) is regarded doubtful. The records of seven species doubtfully reported from North America are confirmed: Atheta amicula (Stephens), A. coriaria (Kraatz), A. fungi (Gravenhorst), A. islandica (Kraatz), A. pallidicornis (Thomson), A. palustris (Kiesenwetter) and Dinaraea angustula (Gyllenhal). Nine Palearctic species are recorded for the first time from North America: Atheta botanicarum Muona, A. dilutipennis (Motschulsky), A. harwoodi Williams, A. longicornis (Gravenhorst), A. nigricornis (Thomson), Geostiba circellaris (Gravenhorst), Gnypeta caerulea (C. R. Sahlberg), Dochmonota rudiventris (Eppelsheim) and Meotica apicalis G. Benick. The genera Homia Blackwelder and Schistoglossa Kraatz are occuring in North America. Pragensiella Machulka, 1941 is regarded a junior subjective synonym of Thecturota Casey, 1893. By the 16 species added here the number of Holarctic species of Aleocharinae amounts to 32.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86402865,"openaccessinfo":{"externalids":{"MAG":"2095006353","ACL":null,"DOI":"10.1163\/187631284X00190","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SUMMARY: In our earlier study of amygdaloid kindling in Papio papio (Pp), the development of partial complex seizure and of focal motor seizure was correlated with bifrontal theta discharge and increasing Rolandic spike discharge respectively and the final stage was characterized by primary generalized convulsive seizure. Since the latter seizure pattern is known to originate from the frontal focus in man, the frontal cortex became suspect in the development of the final stage seizure pattern. Daily prefrontal stimulation showed that Pp can be kindled from this site, culminating in a recurrent spontaneous seizure state identical to that induced by amygdaloid kindling in this species. However, our observation did not support our original assumption regarding the genesis of primary generalized convulsive seizure. Prefrontal and amygdaloid kindling are significantly different with respect to morphology, distribution and propagation of afterdischarge and interictal spike discharge, and speed and pattern of clinical seizure development. Most intriguingly, inter-ictal behavioral aberration associated with depth EEG changes was observed only in the prefrontal animals and not in the amygdaloid animals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1020729,"openaccessinfo":{"externalids":{"MAG":"2419005518","ACL":null,"DOI":"10.1017\/S031716710002062X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The work investigates the importance of the K-T approach in the modelling of pressure cracked structures. T-stress is the constant in the second term of the Williams expression; it is often negligible, but recent literature has shown that there are cases where T-stress plays the role of opening the crack, also T-stress improves elastic modeling at the point of crack. In this research study, the most important effects of the T-stress are collected and analyzed. A numerical analysis was carried out by the extended finite element method (X-FEM) to analyze T-stress in an arc with external notch under internal pressure. The different stress method (SDM) is employed to calculate T-stress. Moreover, the influence of the geometry of the notch on the biaxiality is also examined. The biaxiality gave us a view on the initiation of the crack. The results are extended with a comparison to previous literature to validate the promising investigations.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":233294516,"openaccessinfo":{"externalids":{"MAG":"3133848483","ACL":null,"DOI":"10.3390\/MATH9050507","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Mild encephalitis\/encephalopathy with a reversible splenial lesion (MERS) is a rare clinicoradiological syndrome characterized by transient mild encephalopathy and magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of the corpus callosum (SCC). Multiple causes have been proposed for the pathogenesis of MERS, with infection as the most pre-eminent. Case Presentation: We report the case of a 10-year-old girl with MERS due to scrub typhus. Her clinical manifestations of headache and drowsiness, together with lesions involving the SCC, as shown by MRI, and their complete resolution upon follow-up fulfilled the diagnosis of MERS. At the same time, the characteristic eschar of the skin and the positive Weil-Felix test result confirmed the existence of scrub typhus infection. Conclusions: To the best of our knowledge, we described the first pediatric case of MERS associated with scrub typhus. The case indicated that an MERS patient with fever should be considered as possibly having a scrub typhus infection. The characteristic black eschar of scrub typhus generally occurs after bite of mite that is important and useful to the doctor for making proper diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247629017,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1089\/vbz.2021.0068","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The subject of the study is the role of Christianity in a multicultural society. The ongoing discussion on the relationship of Christianity, especially Catholicism in Poland, and national culture, is the justification for this kind of reflection. It is necessary to separate the functions of institutional Church whose task is to accomplish the mission of salvation, regardless of nationality or state. These are Christians who shall participate in broadly understood public life by implementing Christian values in their lives and decisions. This is guaranteed to them by the human rights. The involvement of the institutional Church in public life constitutes a threat for the Church. The Church is universal in nature and, as such, it is not related to any state system. Such understanding of Christianity allowed for its rapid development in ancient Rome.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":261133333,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32084\/tekapr.2019.12.1-18","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ojs.academicon.pl\/tkppan\/article\/download\/6063\/6334","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"An\u00a0antibody\u00a0(Ab), also known as an\u00a0immunoglobulin\u00a0(Ig),\u00a0is a large, Y-shaped\u00a0protein\u00a0produced mainly by\u00a0plasma cell\u00a0that is used by the\u00a0immune system\u00a0to neutralize\u00a0pathogens\u00a0such as\u00a0pathogenic bacteria\u00a0and\u00a0viruses. The antibody recognizes a unique molecule of the pathogen, called an\u00a0antigen, via the\u00a0fragment antigen binding\u00a0(Fab) variable region.\u00a0Each tip of the \"Y\" of an antibody contains a\u00a0paratope\u00a0(analogous to a lock) that is specific for one particular\u00a0epitope\u00a0(similarly, analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can\u00a0tag\u00a0a\u00a0microbe\u00a0or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by inhibiting a part of a microbe that is essential for its invasion and survival). Depending on the antigen, the binding may impede the biological process causing the disease or may activate\u00a0macrophages\u00a0to destroy the foreign substance. The ability of an antibody to communicate with the other components of the immune system is mediated via its\u00a0Fc region\u00a0(located at the base of the \"Y\"), which contains a conserved\u00a0glycosylation\u00a0site involved in these interactions.\u00a0The production of antibodies is the main function of the\u00a0humoral immune system.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":262238748,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32553\/ijmbs.v6i12.2637","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.ijmbs.info\/index.php\/ijmbs\/article\/download\/2637\/2163","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"As a variation of random linear network coding, segmented network coding (SNC) has attracted great interest in data dissemination over lossy networks due to its low computational cost. In order to guarantee the success of decoding, SNC can adopt a feedbackless forward error correction (FEC) approach by applying a linear block code to the input packets before segmentation at the source node. In particular, if the empirical rank distribution of transfer matrices of segments is known in advance, several classes of coded SNC can achieve close-to-optimal decoding performance. However, the empirical rank distribution in the absence of feedback has been little investigated yet, making the whole performance of the FEC approach unknown. To close this gap, in this paper, we present the first comprehensive study on the transmission scheduling issue for the FEC approach, aiming at optimizing the rank distribution of transfer matrices with little control overhead. We propose an efficient adaptive scheduling framework for coded SNC in lossy unicast networks. This framework is one-sided (i.e., each network node forwards the segments adaptively only according to its own state) and scalable (i.e., its buffer cost will not keep on growing when the number of input packets goes to infinity). The performance of the framework is further optimized based on a linear programming approach. Extensive numerical results show that our framework performs near-optimally with respect to the empirical rank distribution.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":13309895,"openaccessinfo":{"externalids":{"MAG":"2284037143","ACL":null,"DOI":"10.1109\/TC.2015.2435792","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conventionally, a single rank-2 tensor is used to assess the white matter integrity in diffusion imaging of the human brain. However, a single tensor fails to describe the diffusion in fiber crossings. Although a dual tensor model is able to do so, the low signal-to-noise ratio hampers reliable parameter estimation as the number of parameters is doubled. We present a framework for structure-adaptive tensor field filtering to enhance the statistical analysis in complex fiber structures. In our framework, a tensor model will be fitted based on an automated relevance determination method. Particularly, a single tensor model is applied to voxels in which the data seems to represent a single fiber and a dualtensor model to voxels appearing to contain crossing fibers. To improve the estimation of the model parameters we propose a structure-adaptive tensor filter that is applied to tensors belonging to the same fiber compartment only. It is demonstrated that the structure-adaptive tensor-field filter improves the continuity and regularity of the estimated tensor field. It outperforms an existing denoising approach called LMMSE, which is applied to the diffusion-weighted images. Track-based spatial statistics analysis of fiber-specific FA maps show that the method sustains the detection of more subtle changes in white matter tracts than the classical single-tensor-based analysis. Thus, the filter enhances the applicability of the dual-tensor model in diffusion imaging research. Specifically, the reliable estimation of two tensor diffusion properties facilitates fiber-specific extraction of diffusion features.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":40398362,"openaccessinfo":{"externalids":{"MAG":"2055580072","ACL":null,"DOI":"10.1117\/12.2080759","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We introduce a new agent-based model of historical warfare, designed to maintain a structure of command between a regiment and its soldiers. It can model various tactics of dierent kinds of military forces and is simple enough to build massive simulations. The model is used to simulate the Battle of Kokenhausen (1601), waged between armies of the Polish-Lithuanian Commonwealth and the Kingdom of Sweden. After producing results very close to historical data, alternative scenario of the battle is considered.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":112114439,"openaccessinfo":{"externalids":{"MAG":"2340202023","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In article the ratio of concepts the official and the municipal employee is considered. The official of local government opkredelyatsya as \"the elective or working under \nthe contract person who is carrying out organizational functions in local governments and not belonging to category of public servants\". The persons which are carrying out service at positions in bodies of a local samokupravleniye are municipal employees.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":154388140,"openaccessinfo":{"externalids":{"MAG":"2110463481","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo research many clinical data of nonunion cases and discover the reasons for low capacity of bone growth.\n\n\nMETHODS\nFrom October 1999 to April 2009,the source material of 280 nonunion cases were conducted and followed up. The data of the study included 230 males and 50 females,with an average age of 39.4 years old ranging from 19 to 62 years. The fracture position was femur in 129 cases,tibia in 83 cases,humerus in 47 cases, feet radius bone in 21 cases, the ratio was 46:29.6:16.8:7.5. The survey included primary injury process,damage degree and the effect of first treatment,hospital level of first treatment,timing of surgery for the first time, the early callus growth conditions and whether there were obvious technical errors.\n\n\nRESULTS\nThere were 129 femoral nonunion cases with complete data,121 cases derived from closed fractures, 8 cases from open fractures; 111 cases was aseptic nonunion. 90% of femoral aseptic nonunion had no obvious callus growth, 80% of first treatment performed intraday surgical internal fixation, 10% were undergone operation within three days and 90% was early surgery totally.\n\n\nCONCLUSION\nLow quality of bone callus growth is the main reason for current nonunion and the early surgical fixation has much to do with low quality of bone callus growth.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35784927,"openaccessinfo":{"externalids":{"MAG":"2381365615","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nThe aim of this study was to explore the influence of different bone grafts, demineralized freeze-dried bone allograft (DFDBA, OraGraft), and deproteinized bovine bone mineral (DBBM, Bio-Oss) implanted in mouse calvaria defects on gene expression.\n\n\nMATERIALS AND METHODS\nMale C57BL\/6MLac mice were separated into three groups as follows: group 1-defect without graft as control, group 2-DFDBA, and group 3-DBBM. Affymetrix DNA microarrays were used to characterize gene expression in bone after 3 months of graft healing. Differential expression of designated genes discovered by microarray analysis was confirmed using real-time polymerase chain reaction (PCR) and immunohistochemistry.\n\n\nRESULTS\nCompared with normal bone healing, 355 and 1,108 coding genes of bone grafted with DFDBA were upregulated and downregulated, respectively. The upregulated genes were mainly involved in chemokine signaling, macrophage activity, osteoclast activity, cytokine expression, T-cell receptor signaling, apoptosis, and MAPK signaling. The downregulated genes were predominantly involved in calcium regulation in cardiac cells, chemokine signaling, MAPK signaling, and adipogenesis. A total of 306 and 817 coding genes of bone grafted with DBBM were upregulated and downregulated, respectively. The upregulated genes were mainly involved in osteoclast activity, chemokine signaling, B cell receptor signaling, macrophage activity, and signaling of T-cell receptor, MAPK, IL-5, and IL-1. The downregulated genes were predominantly involved in calcium regulation in the cardiac cell and osteoclast activity. Real-time PCR revealed that the DFDBA and DBBM groups showed a higher mRNA level of MMP12, Bcl2A1, S100A4, and Postn compared with the control (P < .05). Histology showed that, compared with the control, the volume of new bone was higher in both types of bone grafts. Immunohistochemistry using an MMP12 antibody confirmed the microarray results because the MMP12 immunoreactivity intensified, and a positive expression of MMP12 increased significantly in the DFDBA and DBBM groups.\n\n\nCONCLUSION\nBoth DFDBA and DBBM had a gene expression network involved in new bone formation, which coincided with an increased expression of MMP-12 and osteoclast activity. Both types of graft materials appeared to connect with genes that stimulate bone remodeling at 3 months of bone grafting.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233447046,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.11607\/jomi.8776","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Delio Ruggiu, who died on August 8th 2004, was an outstanding colleague, but first and foremost a beloved and irreplaceable friend. We heard the news of his sudden and untimely death with immense sadness and a great sense of emptiness, along with a feeling of incredulity: he had got through apparently desperate times before, and none of us thought that this time he had come to the end. In the many years of our life at the Institute, Delio was always there to share so much of significance in the research activity, and his participation was invariably marked by a great sense of responsibility, intellectual rigour and enthusiasm.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86289254,"openaccessinfo":{"externalids":{"MAG":"2123422153","ACL":null,"DOI":"10.4081\/JLIMNOL.2004.157","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This research paper investigates my childhood, the notion of play expressed in self-made toys and their relationship to my sculptural practice. My studio research has been engaged in forming object-based ceramic works that form a series of hand-built artworks. Another aspect embedded in the studio research was to examine the relationships between ancient ceramic history and customs alongside select contemporary practitioners. My paper also investigates civilizations that created ceramic objects and how I consider these traditions when making sculptures.\nMy process stems from my engagement with childhood memories, in my homeland, as a basis to identify themes of my research project. These ideas integrate my family background, the community I was raised in, happiness and creativity. In identifying symbols surrounding these characteristics throughout my investigation, I have focused on games and toys emanating from a particular time of my childhood. My studio research, the creation of ceramic sculptures that have permanent material qualities, has been a personal pursuit, in an attempt to understand my own cultural origins combine with childhood memory.\nThis aim has required me to travel back to my hometown of Kampung Baru, Jitra, Kedah, in Malaysia. The journey allowed me to contemplate my past, document my surroundings and re-experience the process of fabricating self-made toys. Through identification and selection of such objects, studio research and a number of technical strategies implemented such as: material investigations, prototype studies, kiln tests and surface treatments \u2212 were all examined as a basis in for producing sculptural forms.\nThis document is divided into five segments. The first Chapter highlights childhood experiences including play and resourcefulness. The second Chapter explores types of toys and games in childhood. Chapter Three focuses on sculptural elements and influences from various prominent artists. In Chapter Four, studio methodologies are examined using clay-slip and absorbent materials. Chapter Five expands on conceptual approaches to ceramic sculpture as relevant to this thesis.\nThe studio research distinguishes itself from the production of other contemporary ceramic sculptors through adopting a hybrid approach of using clay and fabric as a vehicle for driving innovation and expression. And, by incorporating my cultural background and memories of childhood and those objects significant to me, this thesis brings together a personal artistic case-study that highlights my journey of discovery, contemplation and creative engagement.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":115950867,"openaccessinfo":{"externalids":{"MAG":"2917144319","ACL":null,"DOI":"10.4225\/03\/58AE5DCEA02D9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"About 480 Ba III lines have been identified in the 10 800-400 A range. The spectrum was emitted from a sliding spark discharge. 53 even and 58 odd energy levels have been established, including all levels of the 5p55g, and parts of the 6g and 6h configurations. The 4f orbits show the contraction characteristic of the rare earths. Configuration interaction giving rise to s-f and p-g transitions have been observed. The 2P3\/2 series limit is determined to be 289 100 \u00b1 20 cm-1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120433646,"openaccessinfo":{"externalids":{"MAG":"2005150925","ACL":null,"DOI":"10.1088\/0031-8949\/13\/3\/004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Ninety-four children with idiopathic nephrotic syndrome (17 steroid-resistant with a histological diagnosis of a focal segmental glomerulosclerosis) were typed for HLA-A, B and DR antigens. The patients showed a significant increase of DR7 (58% vs 18%, p less than 0.0001) and of B8-DR3 (27% vs 5%, p less than 0.05). Combination of both markers (DR7 and B8-DR3) was observed in 14 per cent of patients but in none of the controls (relative risk 15.2). Patients with B8-DR3 and DR7 had a more severe course of INS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39513386,"openaccessinfo":{"externalids":{"MAG":"2416183720","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Attention has been focused on the specific pharmacokinetics and clinical pharmacology present during the perinatal period following clinical accidents due to high concentrations of oxygen, vitamin K2, sulfonamides, novobiocin, chloramphenicol or drugs of the tetracycline family. The mechanisms of these therapeutic accidents are subject to certain parameters: renal excretion, inactivation systems, binding to plasma albumin, affinity of the tissues for the drugs, intra and extra-vascular compartment distribution, and pharmacogenetics. The special cases of maternal passage of drugs, either during labor or after birth in the milk given to the newborn, are discussed. Lastly, the ethical problem of \"therapeutic trials\" in newborns are analyzed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":282076,"openaccessinfo":{"externalids":{"MAG":"2419491965","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo explore the distribution the tyes- of human papillomavirus (HPV) in cervical biopsy tissue or exfoliated cell specimen of Chinese women and to estimate the perspective of HPV prophylactic vaccine in China.\n\n\nMETHODS\nA total of 18 studies using polymerase chain reaction to detect HPV types were included in this Meta-analysis. There were 1335, 394, 381 and 2584 cases included in invasive cervical cancer (ICC), high-grade squamous intraepithelial lesions (HSIL), low-grade squamous intraepithelial lesions (LSIL) and normal group respectively. The overall HPV prevalence was estimated by adjusting the variables using unconditional multiple logistic regression model. HPV type-specific HPV prevalence rates of 18 types including HPV6, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 70, 73 and 82 were estimated, after stratified by cervical lesion of Chinese women.\n\n\nRESULTS\nIn ICC, HSIL, LSIL and normal group, the overall HPV prevalence rates were 82.7%, 88.5%, 69.3% and 13.1% respectively, and the HPV16 type-specific prevalence were 61.9%, 46.7%, 21.0% and 3.1%. HIPV16 was the predominant type in all cervical lesion specimen followed by HPV18 and 58 in ICC group, then HPV58 and 52 in HSIL, LSIL and normal. The estimated HPV16\/18-positive fractions were 69.6%, 59.1%, 32.3% and 4.4% respectively in ICC, HSIL and normal. Data from the Meta-analysis showed that the top five common HPV types in ICC women were HPV16, 18, 58, 52 and 31 which contributed for 82.9% of the ICC. Thus the HPV16, 18, 31, 33, 35, 45, 52 and 58 were accounted for 87.7% ICC in China mainland.\n\n\nCONCLUSION\nThe proportional impact of HPV16\/18 vaccine on ICC was estimated as high as 69.6% in China. HPV58 seemed the priority HPV type and should be emphasized enough to be included in the development of new generation HPV vaccine. However, more uniform standardized multi center studies were necessary to get more exact figure about HPV distribution in China.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7690078,"openaccessinfo":{"externalids":{"MAG":"2279809879","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study assesses the fireside erosion-corrosion behavior of nanostructured NiCr coatings in a power plant boiler operating at 750 \u00b0C. In the experiments, Ni-20Cr nanocrystalline powder was synthesized by ball milling and deposited on T91 boiler steel substrates by HVOF spraying. Coated and uncoated steel specimens were thermally cycled in the superheater zone of a coal fired boiler. After 15 heating and cooling cycles, the specimens were examined and erosion-corrosion kinetics were established via weight-change and thickness-loss measurements. The results show that the nanostructured coatings reduced the erosion-corrosion rate of T91 steel by 85%.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":259476466,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.31399\/asm.cp.itsc2014p0546","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Meningiomas are one of the most frequent primary intracranial tumours, representing one-third of all intracranialneoplasms. The vast majority of meningiomas are histologically benign, but recurrence and progression is quite frequent. They occur usually between the 6th and 7th decade, the female\/male ratio is 3:2. Although rare in pregnancy, when occurring, they can cause serious, life-threatening complications due to rapid growth and unfavourable localisation. There are two dominant hypothesis explaining rapid growth in pregnancy: the role of hormonal effects and hemodynamic changes. Several studies tested these theories but none provided unequivocal answer probably because the pathomechanism is complex and multifactorial. We provide an overview of the pathomechanism of meningiomas in pregnancy with emphasis on data obtained by advanced neuropathological, molecular biological, bioinformatic, imaging and epidemiological methods. A better understanding of the processes leading to meningioma development and growth in pregnancy will help us to design personalized therapy and reduce morbidity and mortality.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":3392343,"openaccessinfo":{"externalids":{"MAG":"2512181342","ACL":null,"DOI":"10.18071\/isz.69.0220","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract The encapsulation of rimifon on natural (NZ) and acid-modified (AMZ) zeolites was investigated by UV\/VIS, FTIR, and equilibrium sorption studies in aqueous medium. The UV\/VIS and FTIR spectral investigations provided data on the nature and characteristics of the drug\u2013zeolite complexes. The probable host\u2013guest interactions during rimifon encapsulation in AMZ include van der Waals interactions, as well as H-bonds established between the O-atom from the carbonyl (>C=O) group and N-pyridine\/N-hydrazine atoms in rimifon and zeolite OH-groups. The maximum experimental equilibrium sorption capacity of AMZ (qmax = 7.17 mg\/g) was approximately 24 times higher than that of NZ. Baudu and Fritz\u2013Schlunder isotherms almost overlapped and seemed to be the best-fitting models with regard to the experimental equilibrium data of rimifon sorption on AMZ. The unique properties of AMZ and the established high extend of rimifon encapsulation proved the possibility of its successful application as rimifon-carrier for environmental and medical purposes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34079231,"openaccessinfo":{"externalids":{"MAG":"1697113566","ACL":null,"DOI":"10.1080\/23312009.2015.1069723","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23312009.2015.1069723?needAccess=true&role=button","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We present an overview of recent work on quantum-based atomistic simulation of materials properties in transition metals performed in the Metals and Alloys Group at Lawrence Livermore National Laboratory. Central to much of this effort has been the development, from fundamental quantum mechanics, of robust many-body interatomic potentials for bcc transition metals via model generalized pseudopotential theory (MGPT), providing close linkage between ab initio electronic-structure calculations and large-scale static and dynamic atomistic simulations. In the case of tantalum (Ta), accurate MGPT potentials have been so obtained that are applicable to structural, thermodynamic, defect, and mechanical properties over wide ranges of pressure and temperature. Successful application areas discussed include structural phase stability, equation of state, melting, rapid resolidification, high-pressure elastic moduli, ideal shear strength, vacancy and self-interstitial formation and migration, grain-boundary atomic structure, and dislocation core structure and mobility. A number of the simulated properties allow detailed validation of the Ta potentials through comparisons with experiment and\/or parallel electronic-structure calculations. Elastic and dislocation properties provide direct input into higher-length-scale multiscale simulations of plasticity and strength. Corresponding effort has also been initiated on the multiscale materials modelling of fracture and failure. Here large-scale atomistic simulations and novel real-time characterization techniques are being used to study void nucleation, growth, interaction, and coalescence in series-end fcc transition metals. We have so investigated the microscopic mechanisms of void nucleation in polycrystalline copper (Cu), and void growth in single-crystal and polycrystalline Cu, undergoing triaxial expansion at a large, constant strain rate - a process central to the initial phase of dynamic fracture. The influence of pre-existing microstructure on the void growth has been characterized both for nucleation and for growth, and these processes are found to be in agreement with the general features of void distributions observed in experiment. We have also examined some of the microscopic mechanisms of plasticity associated with void growth.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250741485,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0953-8984\/14\/11\/305","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: Treatment for ruptured dissecting aneurysms of the vertebral artery (VA) varies according to the origin of the posterior inferior cerebellar artery (PICA). However, a PICA originating from the V3 segment has not been reported. Case Presentations: A 49-year-old man with a World Federation of Neurosurgical Societies (WFNS) grade III subarachnoid hemorrhage developed headache and bilateral lower limb weakness. Computed tomographic angiography revealed a right hemorrhagic dissecting aneurysm of the VA at the V4 segment, with a PICA originating from the V3 segment. On the day after endovascular coil embolization of the parent artery, magnetic resonance imaging (MRI) identified ischemic complications of the lateral medullary, ipsilateral cerebellar hemisphere. He had no other complications and was transferred to a rehabilitation hospital with modified Rankin scale (mRS)4. Conclusion: Considering the origins of the PICA and anterior spinal artery (ASA) is important when selecting treatment for hemorrhagic vertebral artery dissecting aneurysm. The morphological features of aneurysms, such as that described herein, are challenging, and perforated vessels might become occluded and initiate ischemic complications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":74790637,"openaccessinfo":{"externalids":{"MAG":"2313655984","ACL":null,"DOI":"10.5797\/JNET.CR.2016-0026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Brantas River has vital functions, such as being a source of drinking water, as a cultivation facility, as a means of transportation, as a recreation area, and as a conservation site. Therefore, there needs to be a system that can monitor the water quality of Brantas River. The purpose of this research was to develop a prototype of the Brantas River geographic information system dashboard as a water quality monitoring system. The research stages included area study, wireless sensor network selection, system architecture design, physical data modelling, system application module development, and system implementation. The research prototype can be used as a real-time water quality monitoring system with good results from testing evaluation.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":108316557,"openaccessinfo":{"externalids":{"MAG":"2922877514","ACL":null,"DOI":"10.1088\/1755-1315\/245\/1\/012052","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1755-1315\/245\/1\/012052\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"An analog VLSI circuit that rank-order filters an array of analog inputs is presented. To prevent the rank-order filtering elements from consuming a prohibitively large amount of space on the input plane, ranks are computed only partially in parallel. This semi-parallel implementation of rank-order filtering is based on the inhibition of winner-take-all circuit elements that have been presented previously in the literature. These rank-order filtering elements are capable of ranking an unlimited number of analog inputs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62760436,"openaccessinfo":{"externalids":{"MAG":"2100609933","ACL":null,"DOI":"10.1109\/ISCAS.1996.539819","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a unified treatment of the phase space of a spatially flat homogeneous and isotropic universe dominated by a phantom field. Results on the dynamics and the late time attractors (Big Rip, de Sitter, etc.) are derived without specifying the form of the phantom potential, using only general assumptions on its shape. Many results found in the literature are quickly recovered and predictions are made for new scenarios. PACS numbers: 98.80.-k, 04.90.+e","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8862345,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives Whilst radiological evidence of compression is the hallmark of degenerative cervical myelopathy [DCM], it is unable to stage or prognosticate. Moreover, asymptomatic spinal cord compression is common and therefore new methods of assessing spinal cord function are required. We aimed to: 1) Evaluate the evidence-base for serum and CSF biomarkers of spinal cord damage in diagnosis, prognosis or predicting response to treatment in DCM 2) Identify serum and CSF biomarkers of spinal cord damage studied in other conditions, which may have relevance to DCM. Design Scoping review. Subjects Human only. Methods A search of MEDLINE and EMBASE was performed. Studies involving DCM patients or biomarkers relevant to spinal cord pathobiology were included. Results 852 results were screened, of which 83 were included. 9 studies explored 12 biomarkers in DCM. NFH (n=3), S100b and NSE (n=2) received most study. 74 studies explored a further 118 biomarkers in other conditions; S100b (n=13), NFH (n=11) and GFAP (n=10) received most study. Overall, 72 studies used targeted approaches, in which candidate biomarkers were chosen in advance. 11 used unbiased approaches, in which high throughput analyses identified candidate biomarkers during the study. Conclusions The evidence-base for use of biomarkers in DCM is limited. Whilst targeted approaches have identified a number of candidate spinal cord markers, few have shown clinical utility. There is a shift towards investigating panels of multiple markers and unbiased, high-throughput approaches.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":86827055,"openaccessinfo":{"externalids":{"MAG":"2913193888","ACL":null,"DOI":"10.1136\/jnnp-2019-ABN.147","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Biological, histological, and ultrastructural studies were made on tumors produced in weanling hamsters inoculated with hamster embryo fibroblasts (HEF) transformed by herpes simplex virus type 2 or with cultured cells (tumor cell lines T1 and T2) derived from the tumor tissues. The malignancy of transformants increased through passages in vitro and in vivo. Histologically, two tumor cells lines (155-4T1 and U-15T1) produced fibrosarcomas and one (U-26T1) produced lesions resembling \"malignant fibrous histiocytomas.\" Ultrastructurally, fibrosarcomas produced by 155-4T1 and U-15T1 consisted mainly of fibroblast-like cells with extracellular collagen fibers, whereas malignant fibrous histiocytoma-like lesions produced by U-26T1 consisted of undifferentiated cells, multinuclear giant cells, histiocyte-like cells, and fibroblast-like cells. Frequently, various kinds of \"nuclear bodies\" were found in the nuclei of tumor cells. Several herpes virus-like particles (120 approximately 140 nm in diameter) were detected in some nuclei of undifferentiated tumor cells produced by U-26T1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21224827,"openaccessinfo":{"externalids":{"MAG":"2408486358","ACL":null,"DOI":"10.20772\/CANCERSCI1959.68.5_653","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of social media has increased considerably the recent years, and users share a lot of their daily life in social media. Many of the users upload images to photo-sharing applications, and categorize their images with textual tags. Users do not always use the best tags to describe the images, but add tags to get \"likes\" or use tags as a status update. For this reason, searching on tags are unpredictable, and does not necessary return the result the user expected. This thesis studies the impact of expanding queries in image searches with terms from knowledge bases, such as DBpedia. We study the methods TF-IDF, Mutual Information and Chi-square to nd related candidates for query expansion. The thesis reports on how we implemented and applied these methods in a query expansion setting. Our experiments show that Chi-square is the method that yields the best result with the best average precision, and was slightly better than a search without query expansion. TF-IDF gave the second best result with query expansion, and Mutual information was the method that gave the worst average precision. Query expansion with related terms is an exiting eld, and the information from this thesis gives a good indication that this is a eld that should be more explored in the future.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":60205345,"openaccessinfo":{"externalids":{"MAG":"587913975","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Engineers increasingly using software to design mat as flexible foundation to save concrete. Instead of soil bearing capacity these software programs often ask for a property called \"modulus of subgrade reaction\". Why this soil property is needed? Is there any relationship between these two parameters? Can one parameter be estimated from the other? This paper digs dip to explain the significance of these parameters and how one parameter relates to the other.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":174786968,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper attempts to investigate the application of Harm Reduction Model that is largely in practice, in the context of Bangladesh. The Injective Drug Users (IDU) is considered to be most susceptible to blood borne diseases and Harm Reduction approach is vital in containing the epidemic of such contagion and depleting the threat eventually. This paper applies mixed methods to identify the commitment and activity of Drop in Centers (DIC's) of major NGOs, which are locally and globally funded, with the support of local government to attain the Health Millennium Development Goal (MDG) of 2021. The paper is investigative to the operational effectiveness of Harm Reduction Model and suggestive to social policy development.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":79558888,"openaccessinfo":{"externalids":{"MAG":"2726524310","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel book-like K0.23V2O5 crystal is obtained by a simple hydrothermal method and is explored as a cathode material for Li-ion batteries for the first time. It exhibits a high reversible capacity (of ca. 244 mA h g(-1) at a current density of 50 mA g(-1)), along with a good rate capability (80 mA h g(-1) at a current density of 1800 mA g(-1)) and a good capacity retention (185.3 mA h g(-1) after 100 cycles).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205941622,"openaccessinfo":{"externalids":{"MAG":"1955079766","ACL":null,"DOI":"10.1039\/c5cc05425g","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The pathway from glucose 6-phosphate (G 6-P) to myoinositol 1-phosphate (Ins 1-P) and myo-inositol (Ins) is essential for the synthesis of various metabolites. In the halophyte Mesembryanthemum crystallinum (common ice plant), two enzymes, myo-inositol O-methyltransferase (IMT1) and ononitol epimerase (OEP1), extend this pathway and lead to the accumulation of methylated inositols, D-ononitol and D-pinitol, which serve as osmoprotectants. This paper describes transcripts for the enzyme, Inps1, encoding myo-inositol 1-phosphate synthase (INPS1), from the ice plant. Two Inps-like sequences are present in the genome. The deduced amino acid sequences of the cloned transcript are 49.5% and 87-90%, respectively, identical to those of yeast and other higher plant sequences. Inps1 RNA amounts are upregulated at least fivefold and amounts of free Ins accumulate approximately 10-fold during salinity stress. Inps1 induction is by transcription, similar to the induction of Imt1. In contrast, Arabidopsis thaliana does not show upregulation of Inps1 or increased amounts of Ins when salt-stressed. The lack of Inps1 induction in Arabidopsis exemplifies differences in glycophytic and halophytic regulation of gene expression at the point of entry into a pathway that leads to osmoprotection. The stress-induced coordinate upregulation of this pathway and its extension by novel enzymes in the ice plant also highlights biochemical differences.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":30010298,"openaccessinfo":{"externalids":{"MAG":"2041433712","ACL":null,"DOI":"10.1046\/J.1365-313X.1996.09040537.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: An association between hearing impairment (HI) and congenital hypothyroidism (CH) has been reported previously. However, in general, studies were retrospective and had small sample sizes, and the results were variable and inconclusive. The aim of our study was to assess the prevalence of HI among patients with CH and to examine factors potentially predictive of HI including severity of CH, etiology of CH, and timing of treatment initiation. Methods: Audiometry was undertaken prospectively in 66 patients aged 3\u201321 years diagnosed with primary CH and 49 healthy matched controls. All patients with HI underwent examination by an otolaryngologist, and in patients with sensorineural loss, brainstem evoked response audiometry was performed. A next-generation sequencing (NGS) panel for genes involved in deafness was performed in patients with sensorineural HI to exclude additional genetic etiologies. Results: HI was found in 19 patients (28.7%). Among them, 5 (7.6%) had moderate to severe bilateral sensorineural impairment and 14 (21.2%) had mild conductive HI. Conductive HI was bilateral in 5 of these patients (36%). None of the controls had HI. No specific etiology was found in patients with HI, and no differences were identified in age at diagnosis, age at initiation of levothyroxine (LT4) therapy, gender, or ethnicity between patients with and without HI. A nonsignificant trend toward lower mean screening TT4 levels was found in patients with HI (compared to those without HI) (3.42 vs. 5.34 \u03bcg\/dL, p = 0.095). No pathogenic variants in genes attributed to HI were identified by NGS in the 5 patients with sensorineural deafness, indicating that HI in these patients was likely attributable to CH rather than other genetic etiologies. Conclusions: Our findings indicate a high prevalence of HI among patients with CH, predominantly of the conductive type. HI was not associated with the etiology of CH or with delayed initiation of LT4 therapy. Audiometry is recommended for children diagnosed with CH and repeat monitoring may be warranted to identify acquired HI and to prevent long-term sequelae of undiagnosed deafness.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225280346,"openaccessinfo":{"externalids":{"MAG":"3083750272","ACL":null,"DOI":"10.1159\/000509775","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.karger.com\/Article\/Pdf\/509775","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Rejection of the Western i.e. North-West European and US model of development in its several varieties is now widespread throughout the 3rd world and there are many new and existing efforts on the part of intellectuals and political elites throughout these areas to assert new and indigenous models of development. These efforts represent serious and fundamental challenges to many cherished social science assumptions and understandings and to the presumption of a universal social science of development. Underestimating or continuing to disregard such changes raises the risk of both perpetuating malcomprehension of the 3rd world areas and retaining a social science of development that is parochial and ethnocentric rather than accurate and comprehensive. The 3rd world critique of the Western model and pattern of development as inapprorpiate and irrelevant or partially so to their circumstances and conditions is both widespread and growing. Recent trends differ from earlier critiques of Western modernization theory because the attacks have become far more pervasive they are shared more generally by society as a whole they have taken on global connotations and the criticisms are no longer solely negative but are now accompanied by an assertion of other alternative often indigenous approaches. The debate is no longer policy implications as well. A nonethnocentric theory of development is coming to the fore. The implications of dealing with indigenous institutions and of nonethnocentric theories and concepts of development are enormous. 3 major areas of impact may be noted. The first concerns the 3rd world and nonwestern nations themselves e.g. their efforts to overcome historical inferiority complexes their reconceived possibilities for development the newfound importance of their traditional institutions the rediscovery of many and complex routes to development and their new sense of pride and accomplishment. It will take a while before the 3rd world can articulate and mold these diverse concepts into viable and realistic development models. Second it is necessary to reexamine a host of essentially Western science assumptions and to be prepared to accept an Islamic African and\/or a Latin American social science of development and to strike some new balances between what is particularin the development process and what does in fact conform to more universal patterns. The third area is major foreign policy implications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204320446,"openaccessinfo":{"externalids":{"MAG":"1794537170","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sweet to the core: Enantioselective formal total syntheses of the title compounds were accomplished in 24 steps from 2-deoxy-D-ribose. The synthesis features a novel cascade of reactions culminating in an intramolecular dipolar cycloaddition to form the tricyclic core of the stemofoline alkaloids from an acyclic diazo imine intermediate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5772006,"openaccessinfo":{"externalids":{"MAG":"2148819995","ACL":null,"DOI":"10.1002\/anie.201205274","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3541778?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Studies of 16 polymorphic loci in the fish Fundulus heteroclitus have uncovered significant directional changes in gene frequencies with latitude (i.e., clines). These spatial patterns could have arisen by primary and\/or secondary intergradation. While we cannot presently distinguish between these two models, mitochondrial DNA analyses indicate that if previous isolation occurred as required for secondary intergradation, it must have been relatively recent and of short duration. Herein we discuss the roles of genetic drift, random migration, nonrandom migration, selection and others as potential driving forces for both modes of cline formation. In addition, we address the potential role of the last glacial period in (1) creating isolating barriers, (2) the opening of unoccupied habitats for range extension, and (3) as a mechanism for thermal selection. While some evidence exists that at least one of the driving forces is selection, the extent to which it and other deterministic forces participate as opposed to various stochastic processes must await further analysis","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":84112343,"openaccessinfo":{"externalids":{"MAG":"1968122116","ACL":null,"DOI":"10.1093\/ICB\/26.1.131","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Learning Objectives: The role of intravenous lidocaine (IVLI) in the adjunctive management of pain in the intensive care unit (ICU) is promising because it uniquely targets sodium channels and has a low potential to contribute to respiratory depression. The safety and effectiveness of IVLI as an adjunct for pain in the ICU setting have not been well studied. The aim of this study was to determine the safety and effectiveness of IVLI for the treatment of pain in ICU patients with varying degrees of organ dysfunction. Methods: This was a retrospective cohort study of ICU patients who received IVLI for any duration as an adjunct to opioids during ICU stay from March 2014 to March 2015. The primary outcomes included the time to a \u2265 20% reduction in pain scores after the initiation of IVLI and the difference in opioid requirements as well as pain scores prior to and during IVLI treatment. Other variables of interest included the presence of IVLI-related adverse events, the dosage and duration of IVLI, ICU and hospital length of stay, and the need for mechanical ventilation while on IVLI. A paired Wilcoxon rank-sum test was used to compare opioid requirements between preand post-treatment. Results: Twenty-one ICU patients with a mean age of 66 years (SD= 14) were included from two different hospitals. Patients received IVLI at an average rate of 0.93 mcg\/min (SD= 0.61) for a mean duration of 48 hours (SD= 33). The mean time to a \u2265 20% reduction in pain scores from the start of IVLI was 3.3 hours (SD= 2.2). The median morphine dose equivalents required during 6, 12, and 24 hours pre-IVLI were significantly higher than post-treatment time periods. (18.3 vs. 10 mg, p=0.002; 41.8 vs. 18.3 mg, p=0.002; 93.5 vs. 30.5 mg, p=0.037). Neurological adverse effects of lidocaine were noted in 3 patients, but the effects were reversed upon IVLI discontinuation. Conclusions: This report suggests that IVLI can be utilized effectively and safely as an adjunctive treatment for selected ICU patients. Additional studies are warranted to confirm safety and identify ICU patients most likely to benefit from IVLI.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37119458,"openaccessinfo":{"externalids":{"MAG":"2557132998","ACL":null,"DOI":"10.1097\/01.CCM.0000509461.31648.7E","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Measuring Your Health (MY-Health) study was designed to fill evidence gaps by validating eight Patient Reported Outcomes Measurement Information System \u00ae (PROMIS \u00ae ) domains (Anxiety, Depression, Fatigue, Pain Interference, Physical Function, Sleep Disturbance, Applied Cognitive Function, and Ability to Participate in Social Roles and Activities) across multiple race-ethnic and age groups in a diverse cohort of cancer patients. This paper provides detailed information on MY-Health study design, implementation, and participant cohort; it identifies key challenges and benefits of recruiting a diverse community-based cancer cohort. Between 2010 and 2012, we identified eligible patients for the MY-Health study in partnership with four Surveillance, Epidemiology, and End Results (SEER) program cancer registries located in California, Louisiana, and New Jersey. \u00a0The overall response rate for the MY-Health cohort ( n = 5,506) was 34 %, with a median response time of 9.5 months after initial cancer diagnosis. The cohort represented meaningful diversity of age (22 % under 49 years of age) and race\/ethnicity (41 % non-Hispanic White) across seven cancers. \u00a0Challenges included lower response rates by race\/ethnic minorities, young, and advanced-stage cancer patients, use of non-final registry information for eligibility identification, and lower use of translated surveys than expected. The MY-Health cohort represents one of the largest efforts to measure the full range of patient-reported symptoms experienced after initial cancer treatment.\u00a0 It provides sufficient diversity in terms of sociodemographics, symptoms, and function to provide a meaningful validation of eight PROMIS measures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":78137376,"openaccessinfo":{"externalids":{"MAG":"2474983714","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This review is based on a symposium\/roundtable session, sponsored by the Division of Toxicology of the American Society for Pharmacology and Experimental Therapeutics, that was held at the 2002 Experimental Biology meeting in New Orleans, LA. The focus is on the role of pharmacogenomics in determining individual susceptibility to chemically induced toxicity. An individual's risk of disease from exposure to toxic chemicals is determined by a complex interplay between genetics, physiology, and concurrent or prior exposures to drugs and other chemicals. The first section of the review defines the basics of pharmacogenetics and pharmacogenomics and assesses the current state of the science. Selected applications to specific enzyme systems are summarized by way of example. New, state-of-the-art approaches to studying genetic determinants of susceptibility, including analytical methods and transgenic technology, are then discussed. Finally, ethical and legal concerns with the application of this knowledge and methodology to human health will be discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9711508,"openaccessinfo":{"externalids":{"MAG":"2015010030","ACL":null,"DOI":"10.1124\/JPET.102.039925","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Prostate cancer is the most commonly diagnosed non-cutaneous solid malignant tumor in the United States. Traditionally, Asian men have been considered low risk for prostate cancer. However, recent research suggests that the prevalence of prostate cancer is increasing in Asian men. This may represent an emerging public health problem with potentially serious consequences for patients and for health care systems. Given a predicted increase in the number of men diagnosed with prostate cancer in Asian countries, there is a clear and present need for optimized protocols for diagnosis and management of this condition in Asian men. Development of such protocols may benefit from novel technologies and lessons learned in Western countries; in this manner patients may receive optimal care and healthcare systems may mitigate the burden of over diagnosis (and subsequent overtreatment) which has complicated management of prostate cancer in the US and other Western nations. Genomic and other molecular testing offers a unique way to stratify oncological risk beyond simple serum, histological, and radiographic markers. These technologies measure genomic or molecular markers that provide novel insights into the biology of prostate tissue and prostate tumors. A variety of molecular biomarkers are in commercial use currently; these include tests designed to: (I) appropriately identify men for prostate biopsy, (II) select men likely to benefit from definitive treatment, and (III) determine which men who should consider adjuvant treatment after initial therapy. Integration of these molecular markers into the care of prostate cancer patients will require changes in how physicians make clinical decisions and counsel patients. These technologies must also be considered in light of improvements in imaging for prostate cancer. In the future, appropriate utilization of traditional, molecular, and radiographic tools will hopefully optimize care of the prostate cancer patients while simultaneously reducing costs to healthcare systems.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":183809256,"openaccessinfo":{"externalids":{"MAG":"2337730784","ACL":null,"DOI":"10.21037\/tau.2016.s002","PubMedCentral":"4842494","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.21037\/tau.2016.s002","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The Segment Anything Model (SAM) has established itself as a powerful zero-shot image segmentation model, employing interactive prompts such as points to generate masks. This paper presents SAM-PT, a method extending SAM's capability to tracking and segmenting anything in dynamic videos. SAM-PT leverages robust and sparse point selection and propagation techniques for mask generation, demonstrating that a SAM-based segmentation tracker can yield strong zero-shot performance across popular video object segmentation benchmarks, including DAVIS, YouTube-VOS, and MOSE. Compared to traditional object-centric mask propagation strategies, we uniquely use point propagation to exploit local structure information that is agnostic to object semantics. We highlight the merits of point-based tracking through direct evaluation on the zero-shot open-world Unidentified Video Objects (UVO) benchmark. To further enhance our approach, we utilize K-Medoids clustering for point initialization and track both positive and negative points to clearly distinguish the target object. We also employ multiple mask decoding passes for mask refinement and devise a point re-initialization strategy to improve tracking accuracy. Our code integrates different point trackers and video segmentation benchmarks and will be released at https:\/\/github.com\/SysCV\/sam-pt.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259316593,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2307.01197","PubMedCentral":null,"ArXiv":"2307.01197"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We investigate the reliability of the `Furfine filter' often used to identify interbank loans and interest rates from interbank payments settled at central banks. To this end, we have been granted access to records of all unsecured overnight interbank loans during a month from the banks that participated in Norges Bank's real-time gross settlement system. The filter applied was able to identify each of these loans and correctly derive the associated interest rates. The filter's reliability is also supported by additional evidence based on the Norwegian Overnight Weighted Average (NOWA) interest rates beyond the survey month. Sensitivity analyses suggest the share of false or overlooked loans may remain small if the filter design largely incorporates interbank market conventions regarding loan size requests and interests rate quotes.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":169081020,"openaccessinfo":{"externalids":{"MAG":"2900070602","ACL":null,"DOI":"10.2139\/SSRN.3334894","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In brief: Physicians of all specialties are likely to treat surfing injuries as the sport increases in popularity and is done in nontraditional areas-such as in commercial aquatic parks. Articles in the medical literature suggest that head lacerations and nose fractures are the most common injuries; these usually occur when the surfboard strikes the surfer. This finding was supported in a survey of 55 plastic surgeons in San Diego County, who reported the number and kinds of surfing injuries they had treated over the past ten years. The survey results indicated that lacerations may be deeper than expected from their surface appearance, and that surfboard fragments are often driven into the wound if the board breaks. The author describes the techniques used to irrigate, debride, and close lacerations caused by surfboards.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205466747,"openaccessinfo":{"externalids":{"MAG":"2465341755","ACL":null,"DOI":"10.1080\/00913847.1989.11709734","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We study the chaotic and secular evolution of hierarchical quadruple systems in the $3+1$ configuration, focusing on the evolution of mutual inclination of the inner binaries as the system undergoes coupled Lidov-Kozai (LK) oscillations. We include short-range forces (SRF; such as those due to tidal and rotational distortions) that control the eccentricity excitation of the inner binary. The evolution of mutual inclination is described, a priori, by two dimensionless parameters, $\\pazocal{R}_0$, the ratio between the inner and outer LK time-scales and $\\epsilon_{SRF}$, the ratio between the SRF precession and the inner LK precession rates. We find that the chaotic zones for the mutual inclination depend mainly on $\\pazocal{R}_0$, while $\\epsilon_{SRF}$ controls mainly the range of eccentricity excitation. The mutual inclination evolves chaotically for $1\\lesssim \\pazocal{R}_0\\lesssim 10$, leading to large misalignments. For $0.4 \\lesssim \\pazocal{R}_0 \\lesssim 0.8$, the system could be weakly excited and produce bimodal distribution of mutual inclination angles. Our results can be applied to exomoons-planets in stellar binaries and Warm\/Hot Jupiters in stellar triples. Such systems could develop large mutual inclination angles if the inner binary is tight enough, and also high eccentricities, depending of the strength of the short-range forces. Future detections of tilted Warm\/Hot Jupiters and exomoons could put our mechanism under observational tests.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":96442225,"openaccessinfo":{"externalids":{"MAG":"2766189559","ACL":null,"DOI":"10.1093\/mnras\/stx3005","PubMedCentral":null,"ArXiv":"1710.05920"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1710.05920","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We present a technique for stabilising the unstable calcaneocuboid joint. The joint is approached laterally, elevating the extensor digitorum brevis muscle. Once the joint is exposed, two parallel tunnels are drilled into the calcaneal neck and cuboid. The harvested gracilis tendon is prepared with whip stitches, and passed through the tunnels in a plantar-dorsal manner. The dorsal limbs of the graft are then pulled across the joint in parallel. The ends are fixed in the calcaneum and cuboid, respectively, using biotenodesis screws (Arthrex; Florida, USA). This technique recreates the dorsal support of the cuboid part of the bifurcated ligament and the dorsal calcaneocuboid ligament, while also augmenting the plantar calcaneocuboid ligament. So far, we have used this technique in one patient with a good result. \n \n \n \nFigure 1 \n \nAnatomical calcaneocuboid joint stabilisation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29823276,"openaccessinfo":{"externalids":{"MAG":"113200561","ACL":null,"DOI":"10.1308\/003588408X285991f","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary. A previous study demonstrated the establishment of a murine testicular antigen (mTA)\u2010specific CD4+ T\u2010cell line (designated BT.1) which was capable of transferring experimental autoimmune epididymo\u2010orchitis to naive recipient mice. The disease transfer was antigen\u2010specific, because no inflammatory lesion was observed in any other organs and tissues of the recipients. In this study, to investigate the local environment of BT.1 cells, the effect of the cells and their culture supernatant on a local tissue integrity was studied. When BT.1 cells were seeded on cultured fibroblastoid cell monolayers, the cells completely disrupted these monolayers in spite of the absence of the specific antigens. Moreover, the culture supernatant of BT.1 cells induced non\u2010specific dermal inflammation when injected into skin tissue of normal syngeneic mice. Therefore, BT.1 cells were shown to devastate a tissue integrity and cause attraction and activation of inflammatory cells of the recipient origin in a local environment. These results suggest that the transferred BT.1 cells will specifically home to the testis and epididymis of recipients but the following devastation of seminiferous tubules and epididymal ducts might be non\u2010specifically produced by the inflammatory cells of both donor and recipient origin in the lesion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20678271,"openaccessinfo":{"externalids":{"MAG":"2059424336","ACL":null,"DOI":"10.1111\/j.1439-0272.1993.tb02688.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1111\/j.1439-0272.1993.tb02688.x","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A selfish behavior detection technique is investigated to assist secure cooperative transmission at the physical layer. The detection technique calculates the correlation ratio between signals received from the diversity branches to determine the relay's behavior in amplify and forward cooperation strategy. The correlation ratio is considerably reduced because the relay's selfish behavior makes the correlation between the received signals in the diversity branch degraded. Simulation results show that the proposed mechanism can effectively detect selfish nodes and performance will be improved significantly with the destination's detection technique.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":111982104,"openaccessinfo":{"externalids":{"MAG":"2378558192","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Early reversal of profound rocuronium-induced neuromuscular blockade by sugam-madex in a randomized multicenter study: efficacy, safety, and pharmacokinetics. management of rocuronium-induced anaphylactic reactions with sugammadex: a case report. Editor\u2014An otherwise healthy 14-yr-old child underwent T3\u2013 L2 posterior spine fusion for progressively worsening idiopathic scoliosis. Invasive arterial pressure and intraoperative neuro-physiological monitoring (IONM) were planned in addition to standard ASA monitoring for the procedure. After uneventful induction of general anaesthesia, a radial arterial line and electrodes for somatosensory evoked potential (SSEP\u2014bilateral median and posterior tibial nerves) and trans-cranial motor evoked potential (MEP) were placed. General anaesthesia was maintained with 0.6 MAC of sevoflurane supplemented with remifentanil infusion. Neuromuscular blockers were avoided in order to optimize MEP signals. An hour into the procedure, without any abrupt changes in the depth of anaesthesia or surgical stimulus, we noted the sudden appearance of a persistent double systolic peak in the arterial line tracing with concurrent changes in the plethysmographic trace (Fig. 1). ECG tracing, arterial pressure, and SSEP signals remained stable during this episode. The arterial line tracing looked similar to pulsus bisferiens which has been described in patients with hypertrophic obstructive car-diomyopathy (HOCM) and aortic regurgitation. 1 The tracing suddenly reverted back to normal only to reappear intermittently. We noted that the distortion of arterial and plethysmographic waveform was temporally associated with repeated flexion of the wrist secondary to median nerve stimulation for SSEP monitoring and correlated with the stimulation frequency (3 Hz) which was being used for SSEP. Invasive arterial monitoring is a commonly used haemo-dynamic monitoring tool in the operating theatre and intensive care units and its signals are subject to artifacts arising from catheter clotting, transducer flushing, over-and under-damping, and various movements. 2 Eipe and Bertram 3 have reported similar interference to arterial line tracing from SSEP signals. In this particular scenario, the temporal association of the aberrant arterial and ple-thysmographic trace with the SSEP stimulation, approximation of the plethysmographic heart rate tracing with SSPE stimulation frequency, unaltered ECG trace, and stable haemodynam-ics all pointed towards a mechanical artifact rather than the unmasking of a potentially ominous clinical scenario (HOCM Note: Yellow arrow showing double systolic peaked arterial line tracing Orange arrow shows two peaks in plethysmograph tracing per QRS complex with apparent doubling of heart rate (frequency ~3 Hz which correlated with stimulation frequency of SSEP) Fig 1 Photograph of the screen of the monitor to show the artifacts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15778071,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Environmental planning, oriented towards recognising \"natural, historic and cultural values\" throughout the territory, tests innovative techniques and methods based on the convergence of expert and local knowledge which creates an overall context used to evaluate the compatibility of the transformation carried out. To this, criteria is applied which is long-term in the sustainable use of resources and effective in the developmental planning of the territory. The environmental approach to planning is therefore able to interface scientific, technical and other knowledge, facilitating an ethical decision making process in order to reach an agreement. \nThe conflict between the fragmentation of expert knowledge, unequivocal position of the environment and the plurality of the developmental proposals for use or transformation of the territory, requires reflection and a concise vision based on recognising local values. Experience of park planning and historic cultural resources has helped in developing this theme, above all in the light of innovations introduced by law 394\/1991 which have required a critical re-evaluation of the \"planning view\" regarding environmental problems. In particular, the nature of substitution which the law has impressed on park planning as opposed to other types of planning (urban, territorial, environmental, and landscape planning) seems to imply the need to create, for every protected area, an instrument to manage the territory. As far as possible this should be able, on the one hand to systematise an interdisciplinary summary of knowledge and on the other to coherently effect the multiple norms afferent to the various disciplinary and environmental components. \nThe experience of park planning repeatedly highlighted the need to codify new paradigms o recognition, interpretation of values and consequent issues in the use of the environment. The inadequacy of traditional methodological apparatus \u2013 urban planning instruments, manifests itself, in these cases, in the problem of using the zoning paradigm to assess the complexity of environmental phenomenon. Problems present themselves following the environmental system networks in order to pinpoint boundaries of areas where action needs to be taken to conserve and protect the landscape, acts to guarantee the variety and abundance of fauna and flora present and at the same time to guaranteeing economical development. In the case of historic centres, by recognising characteristics, places, architecture and identifying signs in social and productive spaces incentives should be provided for coherent policies of urban protection and redevelopment which encourage transformation and use, compatible with the conservation of present historical and cultural values. \nBased on these considerations, the thesis tests an innovative approach which uses an informative \ngeographic system with an interdisciplinary analytical basis. This reveals the systemic interaction between the natural components and signs of man in the construction of environments and highlights how to conserve them. For this purpose a SIT was carried out in order to highlight environmental, historical and cultural sensitivity and anthropological activity allowing the construction and sharing of contextual knowledge in order to plan and monitor the interventions considered admissible in sensitive areas of the territory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":128214080,"openaccessinfo":{"externalids":{"MAG":"7680729","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo evaluate the influence of 2% ibopamine eye drops on the results of computerized visual field exams.\n\n\nMETHODS\nNormal volunteers from CEROF-UFG were selected, with no variance in the ophthalmologic examination that could affect the visual field test. The volunteers underwent computerized visual field test before and after dilation with 2% ibopamine eye drop or cyclopentolate, with a minimum interval of three days between them and in a random order. Global indices and number of altered points were compared between the groups.\n\n\nRESULTS\nThirty eyes of 30 normal individuals were selected. There was no statistically significant difference on Mean Deviation (MD) before and after dilation with ibopamine (MD: -1.05 +\/- 0.26 dB vs. -1.47 +\/- 0.20 dB, P=0.08). However, after cycloplegia (MD: -3.19 +\/- 0.29 dB), there was a significant difference on MD (P<0.001 for both ibopamine and pre-dilation). No significant difference was detected in the Pattern Standard Deviation when comparing ibopamine with pre-dilation and cycloplegia values, but it was statistically significant comparing pre-dilation to cycloplegia (P=0.04). The number of altered points in the Pattern Deviation graphic were not significant comparing all pairs. There was a statistically significant difference in the number of altered points in the total deviation graphic before dilation and after cycloplegia (n: 8.86 +\/- 1.51 vs. 25.72 +\/- 2.96 points, P<0.001), and comparing cycloplegia with ibopamine (ibopamine: 9.75 +\/- 1.85 points, P<0.001).\n\n\nCONCLUSION\nIbopamine 2% eye drops seem to not modify the results of visual field tests in normal individuals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22100398,"openaccessinfo":{"externalids":{"MAG":"2973390616","ACL":null,"DOI":"10.1590\/S0004-27492009000300016","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SETTING\nQueen Elizabeth Central Hospital (QECH) and Blantyre district, Malawi.\n\n\nOBJECTIVE\nTo investigate the use that tuberculosis (TB) patients in Malawi make of traditional healers and traditional medicine.\n\n\nDESIGN\nA questionnaire study was carried out on 89 smear-positive pulmonary TB patients admitted to QECH. Seven traditional healers in Blantyre were also interviewed about their knowledge, attitudes and practice of patients whom they considered to have TB.\n\n\nRESULTS\nOf the 89 patients, 33 (37%) visited a traditional healer before seeking regular medical care. Patients spent a median length of 4 weeks with the traditional healer. During this time, 24 patients did not improve or deteriorated while on traditional treatment. No patient was referred to the medical services by the traditional healer. All traditional healers claimed to know about TB. Four said they would refer a patient to hospital if their treatment was not curative. In 1995, six traditional healers claimed to have cured 116 patients with TB.\n\n\nCONCLUSION\nIt is important to involve traditional healers in the educational activities of the National TB Control Programme. These healers need to be taught to recognise and refer patients with TB, whom they should not treat, but at the same time be encouraged to administer safe treatments for conditions which are more amenable to their practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12495357,"openaccessinfo":{"externalids":{"MAG":"2335388925","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The nuclear factor of activated T-cells (NFAT), originally identified in T-cells, has since been shown to play a role in mediating Ca2+-dependent gene transcription in diverse cell types outside of the immune system. We have previously shown that nuclear accumulation of NFATc3 is induced in ileal smooth muscle by platelet-derived growth factor in a manner that depends on Ca2+ influx through L-type, voltage-dependent Ca2+ channels. Here we show that NFATc3 is also the predominant NFAT isoform expressed in cerebral artery smooth muscle and is induced to accumulate in the nucleus by UTP and other Gq\/11-coupled receptor agonists. This induction is mediated by calcineurin and is dependent on sarcoplasmic reticulum Ca2+ release through inositol 1,4,5-trisphosphate receptors and extracellular Ca2+ influx through L-type, voltage-dependent Ca2+ channels. Consistent with results obtained in ileal smooth muscle, depolarization-induced Ca2+ influx fails to induce NFAT nuclear accumulation in cerebral arteries. We also provide evidence that Ca2+release by ryanodine receptors in the form of Ca2+ sparks may exert an inhibitory influence on UTP-induced NFATc3 nuclear accumulation and further suggest that UTP may act, in part, by inhibiting Ca2+ sparks. These results are consistent with a multifactorial regulation of NFAT nuclear accumulation in smooth muscle that is likely to involve several intracellular signaling pathways, including local effects of sarcoplasmic reticulum Ca2+release and effects attributable to global elevations in intracellular Ca2+.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29701620,"openaccessinfo":{"externalids":{"MAG":"1976527906","ACL":null,"DOI":"10.1074\/jbc.M203596200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sense Organs of Nereis.F. E. Langdon 1 has described three kinds of sense organs in the, skin of Ne;-eis virens Sars. The diffuse sense organs consist of groups of bipolar nerve cells whose bodies form a part of the external epidermis, whose peripheral ends extend as sense bristles into the surrounding water, and whose central projections are in the form of nerve fibres terminating probably as pericellular nerve baskets around ganglion cells in the central nervous organs. The diffuse sense organs are most numerous in those parts of the body most exposed to contact, and represent organs for mechanical and possibly chemical stimulation. The prostomium possesses an anterior and a posterior pair of cephalic organs, each of which consists of a group of bipolar cells whose peripheral processes end in the epidermis, and whose central processes terminate in the brain. The anterior pair differ from the posterior in that their cell bodies lie between epidermis and brain instead of in the brain. The third class of organs consists of groups of spirally arranged cells, hence called spiral organs. The central processes from these organs take a direction appropriate for nerve fibres, but have not been traced into nervous organs. Their function as epidermal eyes is, therefore, hypothetical. P","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":222322514,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1086\/277637","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.journals.uchicago.edu\/doi\/pdfplus\/10.1086\/277637","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nGenetic background has a major influence on the manifestation of multifactorial diseases such as hypertension in which severe complications may be caused through an interaction with additional factors, which may be genetically determined. We have previously described a genetic model of malignant hypertension (MH) in rats carrying the mouse Ren2 gene (TGRmRen2-27), in which the phenotype is dependent on the genetic background.\n\n\nMETHODS\nUsing a single homozygous TGRmRen2-27 male as transgene donor, we produced two F1 populations with (a) 100% penetrance of MH in progeny heterozygous for the Fischer F344 genetic background and (b) 58.5% penetrance in progeny heterozygous for the Lewis genetic background. To identify the modifier loci affecting the phenotype, a cohort of 252 males was produced by breeding the same single male with Fischer-Lewis F1 females. The progeny were phenotyped for clinical and pathological features of MH.\n\n\nRESULTS\nGenome-wide screening and quantitative trait loci (QTL) analysis identified two loci, on chromosome 10 (LOD 4.4) and on chromosome 17 (LOD 3.9) close to the Ace and At1 genes, respectively, which contribute to the lethal MH phenotype. Their influence on mortality was consistent with a multiplicative effect of the two loci. In addition, we found higher plasma angiotensin-converting enzyme activity in progeny receiving the Fischer allele than in progeny receiving the Lewis allele (123.5 +\/- 9.5 vs. 91.8 +\/- 4.9 U\/liter, P < 0.01), suggesting the association of angiotensin-converting enzyme and MH.\n\n\nCONCLUSIONS\nOur study demonstrates the application of a transgene as a \"major gene\" to facilitate the identification of modifier loci, which can affect the phenotype of MH, and reveals Ace and At1 as candidate genes involved in the manifestation of the MH phenotype.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-26":1,"unknown":2}},"corpusid":40712559,"openaccessinfo":{"externalids":{"MAG":"2055316655","ACL":null,"DOI":"10.1046\/J.1523-1755.1999.00571.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A model has been developed to describe the emission of electrons from silicon across the oxide energy barrier of metal-oxide-silicon structures. An optical absorption coefficient, exclusively describing the transmission of electrons which are emitted across the barrier, is split from the corresponding experimental quantity for the entire absorption range. This makes it possible to approximate the photo yield in terms of absorption coefficients and density of states without need for explicitly calculated matrix elements of optical transitions. Using this method, theoretical emission yield curves are found in good agreement with measured data. An important conclusion from this work is that values of oxide energy barrier heights should be extracted from different features of the yield data than most often done in the literature. This replaces a commonly used practice for determining the barrier heights, which is shown to be based on optical bulk properties of the silicon crystal. VC 2012 American Institute of Physics. [http:\/\/dx.doi.org\/10.1063\/1.4754512]","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55863706,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The VX2 carcinoma-bearing rabbit is an animal model for tumor-induced hypercalcemia, thought to be due to increased bone destruction effected by prostaglandin E2. The present experiments suggest that the pathophysiology of the hypercalcemia differs from that previously proposed. Tumor was transplanted intramuscularly into 2.5- to 3-kg male New Zealand White rabbits, which were conditioned to a 1.5% calcium diet and treated with daily subcutaneous injections of dichloromethane diphosphonate (10 mg . kg-1 . day-1), a potent inhibitor of bone resorption, or 0.9% NaCl (2 ml . kg-1 . day -1). The diphosphonate had no significant effect on plasma Ca2+ in either group. After day 31, half the animals of each group were fed a calcium-free diet. This normalized the plasma Ca2+ in each VX2-bearing rabbit within 3 to 4 days but had little effect in control rabbits. In a second series of experiments, VX2-bearing rabbits maintained on standard rabbit chow were treated for 11 days with parenteral indomethacin (30--60 mg\/day) or 0.9% NaCl. Although indomethacin normalized the markedly elevated urinary excretion of prostaglandin E2, both treatment groups became severely hypercalcemic. Dietary calcium restriction promptly restored to normal the plasma Ca2+ concentration. In a third series of experiments, rabbits were fed standard rabbit chow and treated with oral indomethacin (40 mg\/day) while control-rabbits were pair fed in identical chow. Transplantation of VX2 tumor into both groups caused hypercalcemia. We conclude that the hypercalcemia produced by this tumor strain is indomethacin resistant and dependent on an increase in gastrointestinal calcium absorption, not on skeletal calcium mobilization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2987221,"openaccessinfo":{"externalids":{"MAG":"2004174737","ACL":null,"DOI":"10.1073\/PNAS.79.2.640","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: Matrix population models have entered the mainstream of conservation biology, with analysis of proportional sensitivities (elasticity analysis) of demographic rates becoming important components of conservation decision making. We identify areas where management applications using elasticity analysis potentially conflict with the mathematical basis of the technique, and we use a hypothetical example and three real data sets (Prairie Chicken [\u2003\u2003Tympanuchus cupido], desert tortoise [Gopherus agassizii], and killer whale [Orcinus orca]) to evaluate the extent to which conservation recommendations based on elasticities might be misleading. First, changes in one demographic rate can change the qualitative ranking of the elasticity values calculated from a population matrix, a result that dampens enthusiasm for ranking conservation actions based solely on which rates have the highest elasticity values. Second, although elasticities often provide accurate predictions of future changes in population growth rate under management perturbations that are large or that affect more than one rate concurrently, concordance frequently fails when different rates vary by different amounts. In particular, when vital rates change to their high or low values observed in nature, predictions of future growth rate based on elasticities of a mean matrix can be misleading, even predicting population increase when the population growth rate actually declines following a perturbation. Elasticity measures will continue to be useful tools for applied ecologists, but they should be interpreted with considerable care. We suggest that studies using analytical elasticity analysis explicitly consider the range of variation possible for different rates and that simulation methods are a useful tool to this end.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1}},"corpusid":53135946,"openaccessinfo":{"externalids":{"MAG":"2020447892","ACL":null,"DOI":"10.1046\/j.1523-1739.1999.98232.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"It has been reported that the three pairs of antagonistic muscles including the mono- and bi-articular muscles in human limbs showed the perfectly coordinating activity pattern, and contributed to the output force control and force direction control at the wrist or ankle joint. This paper deals with a method of the functional evaluation of effective muscle strengths in the muscle coordinate system based on the functional role of the muscles contributing to the output force distribution. The output force distribution demonstrated a hexagonal shape, and the effective strengths of the functionally individual muscles could be calculated from the characteristics of this hexagonal shape. This will lead a human model into much more reality than the model operating in the conventional joint coordinate system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":138870562,"openaccessinfo":{"externalids":{"MAG":"2315915987","ACL":null,"DOI":"10.2493\/JJSPE.65.1772","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article reviews a novel technology, named photochemical internalisation (PCI), for light-directed delivery of transgenes. Most gene therapy vectors are taken into the cell by endocytosis and, hence, are located in the endocytic vesicles. Although viral vectors have developed the means to escape from these vesicles, poor endosomal release is one of the major obstacles for non-viral vectors. PCI is a technology that allows liberation of the entrapped vectors carrying a gene in response to illumination. The method is based on chemical compounds (photosensitisers) that localise specifically in the membranes of endocytic vesicles and, following activation by light, induce the rupture of the vesicular membranes. The released transgenes can further be transferred to the nucleus, transcribed and translated. As gene liberation depends on light, enhancement of gene expression is achieved only at illuminated regions. PCI substantially improves gene transfer in vitro not only with non-viral gene vectors, but, surprisingly, also with adenoviruses and adeno-associated viruses. This article will review the background for the PCI technology and its role for gene delivery using both non-viral and viral vectors. Some aspects of the potential of PCI for site-specific gene delivery in therapeutic situations will also be discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40141151,"openaccessinfo":{"externalids":{"MAG":"2066836739","ACL":null,"DOI":"10.1517\/14712598.4.9.1403","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"With the continuous development of conventional oil and gas resources, the strategic transformation of energy structure is imminent. Shale condensate gas reservoir has high development value because of its abundant reserves. However, due to the multi-scale flow of shale gas, adsorption and desorption, the strong stress sensitivity of matrix and fractures, the abnormal condensation phase transition mechanism, high-speed non-Darcy seepage in artificial fractures, and heterogeneity of reservoir and multiphase flows, the multi-scale nonlinear seepage mechanisms are extremely complicated in shale condensate gas reservoirs. A certain theoretical basis for the engineering development can be provided by mastering the percolation law of shale condensate gas reservoirs, such as improvement of productivity prediction and recovery efficiency. The productivity evaluation method of shale condensate gas wells based on empirical method is simple in calculation but poor in reliability. The characteristic curve analysis method has strong reliability but a great dependence on the selection of the seepage model. The artificial intelligence method can deal with complex data and has a high prediction accuracy. Establishing an efficient shale condensate gas reservoir development simulation technology and accurately predicting the production performance of production wells will help to rationally formulate a stable and high-yield mining scheme, so as to obtain better economic benefits.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":257386011,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/en16052446","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/16\/5\/2446\/pdf?version=1677858409","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In addition to creating or modifying habitat, ecosystem engineers interact with other species as predators, prey, or competitors. The earthworm, Lumbricus terrestris, interacts with the common woodland salamander, Plethodon cinereus, via: (1) ecosystem engineering, by providing burrows that are used as a refuge, (2) direct effects as a prey item, and (3) indirectly, by competing with microinvertebrates, another prey item for P. cinereus. Using enclosures in the forest, I examined the relative strengths of these component pathways between seasons and salamander age classes. I found that the relative strength (partial eta2) of the positive direct (trophic) effect of L. terrestris on the change in mass of P. cineresus was greater than that of the negative indirect effect, but only in summer. Positive effects of ecosystem engineering were only evident over the winter as increased adult survival. This research has implications for how habitat provisioning complements more well-studied species interactions, such as competition and predation, within communities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10730890,"openaccessinfo":{"externalids":{"MAG":"2144656658","ACL":null,"DOI":"10.1890\/11-2024.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The sex of a person with malformation of the external genitals and malformation or absence of the internal organs of generation may be difficult to determine. In recent years it has not been unusual to perform a biopsy on the gonads (at times necessitating laparotomy) to arrive at a valid conclusion. In two instances of malformation we have definitely established the sex of the patients by demonstrating the presence of the female sex hormone in the circulating blood by injecting lipoid extract of the blood into castrated mice and thereby producing a positive (estrual) vaginal spread. 1 The theoretical considerations involved are that a person possessing functioning ovaries, irrespective of whether the tubular tract (vagina, uterus, tubes) and external genitals are malformed or aplastic, should have a demonstrable quantity of female sex hormone in the circulating blood some time between the fifth and fifteenth days after ovulation has taken place.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":72449537,"openaccessinfo":{"externalids":{"MAG":"2055291605","ACL":null,"DOI":"10.1001\/JAMA.1926.02680080020007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A Monte Carlo type reconstruction algorithm (Saxs3D) to yield low-resolution three-dimensional structures from one-dimensional small-angle X-ray scattering data (SAXS) is presented. It is demonstrated that Saxs3D reliably reproduces the shape of several test protein structures, with their respective SAXS profiles calculated theoretically from their known high-resolution atomic coordinate sets. A reconstruction for experimentally obtained scattering data for GroEL, a molecular chaperone, correctly reproduced the gross structural features of GroEL. Compared to other reconstruction methods described in the literature, Saxs3D has the advantage of allowing for any topology of the target structure, does not require any prior estimation of its dimensions, is fast and conceptually very simple.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-30":1}},"corpusid":93237202,"openaccessinfo":{"externalids":{"MAG":"1985447198","ACL":null,"DOI":"10.1107\/S0021889899015976","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules inducing targeted protein degradation have exploited such complexes, proving successful as therapeutics against previously undruggable targets. The C-terminal to LisH (CTLH) complex, also called the glucose-induced degradation deficient (GID) complex, is a multi-subunit E3 ligase complex highly conserved from Saccharomyces cerevisiae to humans, with roles in fundamental pathways controlling homeostasis and development in several species. However, we are only beginning to understand its mechanistic basis. Here, we review the literature of the CTLH complex from all organisms and place previous findings on individual subunits into context with recent breakthroughs on its structure and function.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249087163,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijms23115863","PubMedCentral":"9180843","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1422-0067\/23\/11\/5863\/pdf?version=1653378321","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Diets of red and processed meat have been reported as important risk factors for developing colorectal cancer. Given the racial and ethnic differences in the incidence of colorectal cancer, patterns of food consumption, and areas of residence, particularly in the South, more data is needed on the relationship between residing in a high stroke area, colorectal cancer incidence levels, and red meat and processed meat consumption. We created online surveys to ascertain meat, red meat, and healthy food consumption levels. We used OLS regression to evaluate the association between residence in Stroke Belt states and colorectal cancer incidence quartiles with food consumption. We further used path analysis using structural equation modeling to evaluate if age, sex, race\/ethnicity, income, and comorbidity index mediated the association between residence in the eight-state Stroke Belt, colorectal cancer incidence groups, and meat consumption. Our sample included 923 participants, with 167 (18.1%) residing in the Stroke Belt and 13.9% being in the highest colorectal cancer incidence group. The findings show that residing in a Stroke Belt state is predictive of the consumption of overall meat 0.93 more days per week or red meat 0.55 more days per week compared to those not residing in a Stroke Belt state. These data can be used to develop future diet interventions in these high-risk areas to reduce rates of colorectal cancer and other negative health outcomes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256977425,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/nu15040993","PubMedCentral":"9958908","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/993\/pdf?version=1676538938","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aim: To compare the effect of herbal extract mouthwash and chlorhexidine mouthwash on the dental plaque level. Materials and Methods: The subjects (60 healthy medical students aged ranges between 20 and 25 years) were randomly divided into two groups, that is, the herbal group and the chlorhexidine gluconate mouthwash group. The data were collected at the baseline and 3 days. The plaque was disclosed using erythrosine disclosing agent and their scores were recorded using the Quigley and Hein plaque index modified by Turesky-Gilmore-Glickman. Statistical analysis was carried out later to compare the effect of all the two groups. Results: Our result showed that the chlorhexidine group shows a greater decrease in plaque score followed by herbal extract, but the result was statistically insignificant. Conclusion: The results indicate that herbal mouthwash may prove to be an effective agent owing to its ability to reduce plaque level, especially in low socioeconomic strata.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2861270,"openaccessinfo":{"externalids":{"MAG":"1973238434","ACL":null,"DOI":"10.4103\/0974-8490.155874","PubMedCentral":"4471655","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/europepmc.org\/articles\/pmc4471655","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Perceptual sensors play a crucial role in the next generation of robots due to their potential application in agriculture, biomedicine and industry fields. In this field, with dependence on visual, auditory and tactile techniques, sensors are utilized to intelligently assess their environment. Here, this study investigates a bio-inspired whisker sensor with self-power capability based on triboelectric nanogenerators (TENG) for building an robotic perceptual system. The whisker sensor is composed of cylindrical structure house (52mm in height and 10mm in diameter), a PTFE pellet fixed to the spring-fixed base, four copper (Cu) films attached symmetrically to inner of house, and memory alloys (50mm in length). Generally, the displacement of the whisker rod causes the change in voltage in four direction because of generated tensile. From experiments to data analysis and modeling, the sensor is characterized by simple structure, convenient fabrication, high sensitivity and self power supply without external power supply. Thus, this 3D printable self-powered whisker sensor should be applicable to a wide range of automaton applications.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":231851692,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/YAC51587.2020.9337588","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Let \u03bb ( G ) denote the smallest number of vertices that can be removed from a non-empty graph G so that the resulting graph has a smaller maximum degree. In a recent paper, we proved that if n is the number of vertices of G , k is the maximum degree of G , and t is the number of vertices of degree k , then \u03bb ( G ) \u2264 n +( k \u2212 1) t 2 k . We also showed that \u03bb ( G ) \u2264 nk +1 if G is a tree. In this paper, we provide a new proof of the first bound and use it to determine the graphs that attain the bound, and we also determine the trees that attain the second bound.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264192431,"openaccessinfo":{"externalids":{"MAG":"2897267149","ACL":null,"DOI":"10.20429\/tag.2018.050205","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/digitalcommons.georgiasouthern.edu\/cgi\/viewcontent.cgi?article=1066&context=tag","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was twofold: firstly to investigate differences of values and risk perceptions among young people in rural and urban areas. Secondly to propose a qualitative alternative to examine values in the tradition to Inglehart and Rokeach, who have a quantitative approach. The hypotesis of this study was that it is possible to understand differences of risk perceptions between young people in rural versus urban areas by analysing differences of values between the groups. In this study risk perceptions have been studied according to Beck's theory of risk and risk society. Four homogenous (age, sex) focus groups were made, two in a rural and two in a urban area of Sweden. The respondents had to make decisions togehter about values. They also discussed risk in general and specific examples of risks. The validity of the results was guarantied by using valid tests, trasformed for use in focus groups. The results indicate that a qualitative approach, i.e. focus groups, gives a deeper understanding of Inglehart and Rokeach theories of values, and the study also demonstrates very interesting tendencies when it comes to differences in values and risk perceptions among young people in risk society.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":141839220,"openaccessinfo":{"externalids":{"MAG":"379082245","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Autonomous operations in the proximity of Near Earth Objects (NEO) are perhaps the most challenging and demanding type of mission operation currently being considered. The exceptional variability of geometric and illumination conditions, the scarcity of large scale surface features and the strong perturbations in their proximity require incredibly robust systems to be handled. Robustness is usually introduced by either increasing the number and\/or the complexity of on-board sensors, or by employing algorithms capable of handling uncertainties, often computationally heavy. While for a large satellite this would be predominantly an economic issue, for small satellites these constraints might push the ability to accomplish challenging missions beyond the realm of technical possibility. The scope of this paper is to present an active approach that allows small satellites deployed by a mothership to perform robust navigation using only a monocular visible camera. In particular, the introduction of Non-cooperative Artificial Visual landmarks (NAVLandmarks) on the surface of the target object is proposed to augment the capabilities of small satellites. These external elements can be effectively regarded as an infrastructure forming an extension of the landing system. The quantitative efficiency estimation of this approach will be performed by comparing the outputs of a visual odometry algorithm, which operates on sequences of images representing ballistic descents around a small non-rotating asteroid. These sequences of virtual images will be obtained through the integration of two simulated models, both based on the Apollo asteroid 101955 Bennu. The first is a dynamical model, describing the landing trajectory, realized by integrating over time the gravitational potential around a three-axis ellipsoid. The second model is visual, generated by introducing in Unreal Engine 4 a CAD model of the asteroid (with a resolution of 75 cm) and scattering on its surface a number N of cubes with side length L. The effect of both N and L on the navigation accuracy will be reported. While defining an optimal shape for the NAV-Landmarks is out of the scope of this paper, prescriptions about the beacons geometry will be provided. In particular, in this work the objects will be represented as high-visibility cubes. This shape satisfies, albeit in a non-optimal way, most of the design goals. TABLE OF CONTENTS","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233467870,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tumor angiogenesis contributes to the development of tumor progression. Several vascular endothelial growth factor(VEGF)-targeted agents, administered either as single agents or in combination with chemotherapy, have been shown to benefit patients with advanced-stage malignancies. In particular, bevacizumab is a humanized monoclonal antibody that specifically targets VEGF, inhibiting angiogenesis, thereby impeding tumor growth and survival. It is also possible that combined VEGF and the epidermal growth factor (EGFR) pathway blockade could further enhance antitumor efficacy and help prevent resistance to therapy. Preclinical and clinical studies have shown new various molecular targets and the functional characteristics of tumor angiogenesis, which may provide strategies for improving the therapeutic benefit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30137436,"openaccessinfo":{"externalids":{"MAG":"2340971224","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Combined geological and geochemical evidence suggests that the age of the basement through which the Wudalianchi, Erkeshan, and Keluo (WEK) volcanic rocks in NE China were erupted is post-Archaean. Sr, Nd, and Pb isotope analyses demonstrate that the Miocene to Recent WEK potassic volcanic rocks were derived from an enriched mantle source which had been metasomatised during the Proterozoic. The primary potassic magmas are the products of partial melting of either this enriched mantle source or, more probably, a mixture of this enriched source with an OIB source. In either case, a post-Archaean subcontinental lithospheric mantle with an EM1 signature has made a significant contribution to the WEK potassic rocks.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-26":1,"unknown":2}},"corpusid":129325186,"openaccessinfo":{"externalids":{"MAG":"2051204612","ACL":null,"DOI":"10.2343\/GEOCHEMJ.25.387","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper deals with the hardware implementation of a shunt active filter (SAF) for compensation of reactive power, unbalanced loading, and harmonic currents. SAF is controlled using an adaptive-linear-element (Adaline)-based current estimator to maintain sinusoidal and unity-power-factor source currents. Three-phase load currents are sensed, and using least mean square (LMS) algorithm-based Adaline, online calculation of weights is performed and these weights are multiplied by the unit vector templates, which give the fundamental-frequency real component of load currents. The dc bus voltage of voltage source converter (VSC) working as a SAF is maintained at constant value using a proportional-integral controller. The switching of VSC is performed using hysteresis-based pulsewidth-modulation indirect-current-control scheme, which controls the source currents to follow the derived reference source currents. The practical implementation of the SAF is realized using dSPACE DS1104 R&D controller having TMS320F240 as a slave DSP. The MATLAB-based simulation results and implementation results are presented to demonstrate the effectiveness of the SAF with Adaline-based control for load compensation.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-48":1,"2014-10":1}},"corpusid":19578720,"openaccessinfo":{"externalids":{"MAG":"2161378781","ACL":null,"DOI":"10.1109\/TIE.2009.2014367","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Automated pavement crack image segmentation is challenging because of inherent irregular patterns, lighting conditions, and noise in images. Conventional approaches require a substantial amount of feature engineering to differentiate crack regions from non-affected regions. In this paper, we propose a deep learning technique based on a convolutional neural network to perform segmentation tasks on pavement crack images. Our approach requires minimal feature engineering compared to other machine learning techniques. We propose a U-Net-based network architecture in which we replace the encoder with a pretrained ResNet-34 neural network. We use a \"one-cycle\" training schedule based on cyclical learning rates to speed up the convergence. Our method achieves an $F1$ score of 96% on the CFD dataset and 73% on the Crack500 dataset, outperforming other algorithms tested on these datasets. We perform ablation studies on various techniques that helped us get marginal performance boosts, i.e., the addition of spatial and channel squeeze and excitation (SCSE) modules, training with gradually increasing image sizes, and training various neural network layers with different learning rates.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":220265488,"openaccessinfo":{"externalids":{"MAG":"3036991312","ACL":null,"DOI":"10.1109\/ACCESS.2020.3003638","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background. Multiple myeloma (MM) is the most common hematologic malignancy affecting African Americans, with a younger age of onset and standardized incidence and mortality rates that are twofold higher compared to European Americans despite the presence of clinical features, which are consistent with milder clinical course. The basis for this paradox remains poorly understood. However, evidence suggests a shared genetic susceptibility. Methods. Using 720 participants (259 confirmed MM cases; 461 age-, sex-, ancestry-matched controls) enrolled in the Molecular and Genetic Epidemiology (iMAGE) study of myeloma, we examined the risk of MM associated with a positive family history of cancer and the excess risk observed among AA patients. Family history of cancer was obtained from structured interviews and risk estimates were calculated using odds ratios (OR) and corresponding 95% confidence intervals (CI) from logistic regression stratified by ancestry and median age of MM onset (65 years). Results. Of the total participants included (42% African American), the majority reported a positive family history of cancer (80%), including solid tumors (75%), hematologic malignancies (17%) and MM (4%). A positive family history of any cancer in any relative was strongly associated with an increased risk of MM overall (OR=1.73, 95% CI 1.14-2.60; P=0.008), as well as among African Americans (P=0.03) and participants less than 65 years of age (P=0.0005). MM risk was markedly increased for participants who reported any relative with MM overall (OR=3.06, 95% CI 1.42-6.58; P=0.004) and among participants less than 65 years of age (OR=4.06, 95% CI 1.44-11.5; P=0.005). The magnitude of this effect was greater in African Americans (OR=18.6, 95% CI 2.32-148; P=0.0002) compared to European Americans, and was notable among first-degree relatives (OR=9.90, 95% CI 1.14-85.9; P=0.01). In contrast, MM risk was not significantly elevated for participants who reported relatives with any hematologic malignancy other than MM (OR=1.47, 95% CI 0.96-2.27; p=0.08) nor a positive family history of solid tumors (OR=1.36, 95% CI 0.95-1.95; P=0.09), and these estimates did not differ by ancestry, age of onset or degree of relative. Conclusions. Our observations suggest that the excess risk of MM observed among African Americans and among those with early age of onset may be attributed to shared susceptibility including underlying heritable genetic and environmental factors. Future studies are warranted to examine the relationship between family history of MM with clinical and cytogenetic factors, which are known to differ by ancestry. Citation Format: Gwendolyn I. Pruitt, Howard W. Weiner, Racquel D. Innis-Shelton, Donna Salzman, Kelly N. Godby, Vishnu B. Reddy, Fady M. Mikhail, Andrew J. Carroll, Elizabeth E. Brown. Effect of family history of cancer on the risk of multiple myeloma: Differences by ancestry and age of onset. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1299. doi:10.1158\/1538-7445.AM2014-1299","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":72002431,"openaccessinfo":{"externalids":{"MAG":"2015656707","ACL":null,"DOI":"10.1158\/1538-7445.AM2014-1299","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Eunsil Lee is a Ph.D. candidate in Engineering Education Systems and Design program at Arizona State University (ASU) in the Fulton Schools of Engineering, The Polytechnic School. She earned a B.S. and M.S. in Clothing and Textiles from Yonsei University (South Korea) with the concentration area of Nanomaterials and Biomaterials in Textiles. She began her Ph.D. study in Textile Engineering but shifted her path toward Engineering Education a year later. Her research interests currently focus on engineering doctoral students in underserved populations such as women and international students.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237430754,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Latin America and Africa's large hydrocarbons reserves and China's growing demand for oil have the potential of being a win\u2013win. China's state-owned oil companies have already acquired prime acreage and Chinese state banks also lent billions to oil-producing countries in Latin America and Africa during the opening decades of the twenty-first century in exchange for oil. China's repeated oil deals with countries with a track record of poor governance performance has been much criticised and sometimes showcased as validation of Beijing's larger geopolitical expansion interests. This paper argues that there is still not enough evidence to assert the truthfulness of that claim. By contrast, there are ample examples of governance problems in the oil producing countries China engages with in Latin America and Africa. The author analyses in particular poor performance shown by three governance indicators \u2014\u00a0transparency, accountability, and corruption\u2014 in the oil sector relationship between China, Latin America and Africa. She argues that it is ultimately the responsibility of host countries to take up the long-due task of tackling those weaknesses in order to take full advantage of a potentially promising oil relationship with China.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":203185755,"openaccessinfo":{"externalids":{"MAG":"2970527438","ACL":null,"DOI":"10.4000\/poldev.3174","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.4000\/poldev.3174","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The fundamental question posed in this study is how to approach the construction sector in order to cover its wide scope of activities, its great variety of actors and the external influences on it from the market and institutional environment. Construction includes such diverse economic activities as new production and as repair\/maintenance, itinerant production and stationary manufacture, the production of buildings and constructions, and it involves a large number of actors representing different professions and types, e.g. companies, public utilities and private persons. Thus, the construction sector includes a large number of interrelated actors who are involved in more or less specialised economic activities under the influences of market forces and state regulations. One well-established way to approach construction is the construction process model, which divides construction into its three principal phases, namely, design, production and real estate management. However, this process model puts production issues in focus but does not include manufacture or the growing importance of repair and maintenance, which is becoming apparent in developed European countries. Thus, the construction process model provides a too narrow approach to construction, which is inadequate to capture the diversity and complexity of construction activities. This study presents, as its basic objective, an analysis model of construction, based on the need for a comprehensive approach to construction. The analysis model has its theoretical basis in mesoeconomics, which is described as the intermediate level between micro- and macroeconomics. The analysis model for construction based on mesoeconomics aligns with the structure of a systems analysis, with specific emphasis on a comprehensive aggregation level and consideration of the influences of the institutional environment. Thus, the analysis model developed in this study, referred to as the mesoeconomic analysis, describes the construction sector as an open system, composed of interacting components that carry out economic activities ranging from manufacture, production, to asset management. A test of the mesoeconomic analysis, applied to the construction sectors of Denmark, Germany and Sweden, concluded that the analysis model developed in fact provides an appropriate framework for the analysis of construction at a sector aggregation level and as such, it provides a basis for comparative analysis of the construction sectors of different, developed countries. However, the review of the application of the analysis model also identified difficulties concerning the structure and accessibility of the information required for the analysis and difficulties related to the characteristics of a systems analysis. The conclusion is that the mesoeconomic analysis of construction provides a comprehensive approach, which facilitates a broad field of potential applications. (Less)","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110781578,"openaccessinfo":{"externalids":{"MAG":"2131839914","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A concise account is given of the theory and use of the instrument, together with descriptions of the customary arrangements of apparatus and the methods of etalon adjustment. An approximate expression for resolving power is deduced; values obtained with it are tabulated and shown. Details are given of a photographic method of finding the reflecting power of the metallic films of the etalon. If it is desired to use the instrument in the infra-red or ultra-violet, combinations other than silver films on glass must be used. A list of such combinations is given, with the region for which each is best suited. Finally, as an aid to comparison, some of the most important properties of the etalon, Lummer plate, and echelon are gathered together and tabulated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":95102138,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0950-7671\/3\/5\/301","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper utilizes a novel data on consumer choice under uncertainty, obtained in a laboratory experiment in order to gain substantive knowledge of individual decision-making and to test the best modeling strategy. We compare the performance of logistic regression, discriminant analysis, na\u00efve Bayes classifier, neural network, decision tree, and Random Forest (RF) to discover that the RF model robustly registers the highest classification accuracy. This model also reveals that apart from demographic and situational factors, consumer choice is highly dependent on social network effects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250981232,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim Dissolvable antibiotic-loaded calcium sulphate beads have been utilized for management of periprosthetic joint infection (PJI) and for aseptic revision arthroplasty. However, wound drainage and toxic reactive synovitis have been substantial problems in prior studies. Currently a commercially pure, physiologic product has been introduced that may reduce complications associated with this treatment modality. We aim to answer the question: does a commercially pure, physiologic version of antibiotic-loaded calcium sulfate beads reduce wound drainage and provide efficacious treatment for PJI and aseptic revision arthroplasty? Method Starting January 2010, 756 consecutive procedures were performed utilizing a set protocol of Vancomycin and Tobramycin antibiotics in commercially pure dissolvable antibiotic beads. There were 8 designated study groups: Results Wound drainage in the entire series was 4.2%. Wound drainage was generally seen in cases using higher bead volumes (\u226530cc). The rate of heterotopic ossification was 1.6%. With bead volumes of \u226530cc, we did notice transient hypercalcemia in 12% of the study group (14% hips, 10% knees). The overall rate of infection failure was 2.5%. In the DECRA groups, reinfection failure rate was encouraging, measuring 9.1% in knees and 6.3% in hips. The non-DECRA group with the highest infection rate was Reimplant TKA (6.2%). Conclusions We utilized a large series of commercially pure dissolvable antibiotic-loaded beads in a wide variety of clinical scenarios in patients with substantial comorbidities. Our rate of wound drainage, compared to prior studies utilizing gypsum products, was reasonably good. Additionally, our infection failure rates were encouraging. Over-stuffing knee joints with too many beads, in our clinical review, does affect wound drainage rates. By removing impurities from calcium sulfate, we do not see the substantial toxic synovial reaction compared to the traditional gypsum-washed products. We feel that commercially pure, physiologic antibiotic-loaded dissolvable beads are an acceptable delivery tool for local antibiotic delivery in aseptic and septic revision joint arthroplasty of the hip and knee. In our opinion, further study is warranted. We advocate future randomized studies to examine the potential of improving outcomes of PJI and aseptic revision arthroplasty.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78641458,"openaccessinfo":{"externalids":{"MAG":"2580956574","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The value of specially designated sites in conserving biodiversity has been a hotly debated issue for many years in the UK and elsewhere. The debate recently has been given fresh impetus in England by the creation of Natural England, the new Government Agency responsible for the protection and enhancement of the natural environment, and the challenges facing the management of designated sites resulting from the increasingly tangible effects of climate change. In the freshwater environment, the role of designated sites is under a particular spotlight because of the implementation of the European 'Water Framework Directive', which aspires to holistic, ecologically based management of aquatic habitats. This paper explores the underlying premises of, and rationale for, special site designations for wildlife and provides a frank account of the inevitable clash of management philosophies that designations create in the freshwater environment. It draws on experiences of managing designated freshwater sites in England over the past decade from within English Nature, the former statutory agency for nature conservation (succeeded by Natural England). The issues and principles discussed, are however, highly relevant to the rest of the UK, other European Member States and countries further afield. A positive role is outlined for designated sites in freshwater conservation, which addresses these management conflicts in a way that not only meets Government obligations towards these sites but also paves the way for informed, progressive management of the wider freshwater resource. As part of this account, attempts are made to clarify the relationship between key biodiversity-related policy drivers in the freshwater environment and to explain how the spectre of climate change can be addressed within designated site management. The importance of strategic freshwater science, collaboratively designed and funded, in maximising the value of the designated freshwater site network to the wider freshwater habitat resource, is stressed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55084865,"openaccessinfo":{"externalids":{"MAG":"1998269403","ACL":null,"DOI":"10.1608\/FRJ-1.1.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\ufffd\ufffd ! \ufffd\ufffd !\" \ufffd\ufffd !\"#$% \ufffd\ufffd !\" \ufffd\ufffd \ufffd\ufffd ! Objectives. To review evidence of iodine deficiency and clinical thyroid disorders in Hong Kong. Data sources. Publications on local dietary iodine intake, the iodine content of local food items, and clinical thyroid problems in the Hong Kong population. Data extraction. Data was extracted and evaluated independently by the authors. Data synthesis. Iodine is an essential nutrient. Iodine deficiency can lead to goitre, hypothyroidism, mental deficiency, and impaired growth. It is now appreciated that determination of goitre incidence in children alone may grossly underestimate the problem of iodine deficiency in a population. In total, the evidence indicates that iodine deficiency exists in Hong Kong, leading to clinical problems of transient neonatal hypothyroidism, goitrogenesis, and thyroid disorders in pregnant women and neonates, as well as thyroid dysfunction in the elderly. Conclusion. A supplementation programme aimed at a relatively uniform iodine intake is recommended to avoid deficient or excessive iodine intake in subpopulations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":196426477,"openaccessinfo":{"externalids":{"MAG":"2165775394","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This research aims to understand how leaders' self-perception of their gender role identity, described as agentic or communal, influences their followers' perception of transformational leadership. Agentic attributes are stereotypically masculine while communal attributes are stereotypically feminine. Drawing on role congruity theory (Eagly\u00a0&\u00a0Karau, 2002) and leadership prototype theory (Lord\u00a0&\u00a0Maher, 1993), we propose a theoretical model to investigate the influence of leader sex and stereotypical gendered perception of leaders on perceptions of transformational leadership among their followers. Using a sample of\u00a0260 employees and their\u00a065\u00a0immediate supervisors from French organizations, the results of multilevel structural equation modeling suggest that female leaders who self-describe as highly communal are perceived by followers as more transformational than male leaders. Contrary to our hypothesis, the results reveal an unexpected positive relationship between women's agentic attributes and follower perceptions of transformational leadership. Our findings develop role congruity theory by demonstrating the influence of gendered stereotypes not only for female but also male leaders.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":149452981,"openaccessinfo":{"externalids":{"MAG":"2904662470","ACL":null,"DOI":"10.3917\/MANA.213.0944","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is shown that a stretcher consisting of a mirror optical system and reflecting diffraction gratings can be calculated by geometrical optics methods. Expressions are derived which describe the influence of parameters of the stretcher optical system (including its aberrations) on the stretcher group velocity dispersion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122353551,"openaccessinfo":{"externalids":{"MAG":"2055477754","ACL":null,"DOI":"10.1070\/QE2008V038N11ABEH013830","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"AIMS AND OBJECTIVES\nTo compare the accuracy and appropriateness of auscultatory (manual) and oscillometric (automated) devices for measuring blood pressure in clinical settings.\n\n\nBACKGROUND\nAccurate measurement of blood pressure is integral to early recognition of deterioration in the condition of a patient. Despite recommendations regarding the use of auscultatory devices in situations where treatment decisions are made dependent on blood readings, the use of automated machines is becoming common practice.\n\n\nDESIGN\nSystematic review.\n\n\nMETHODS\nA search of the Medline, CINAHLPlus and The Cochrane Library databases was undertaken for papers published in English between January 1997-May 2009. Sixteen studies were identified that fulfilled the inclusion criteria. After quality assessment, all were included in the review. Results are presented in tabular and narrative form.\n\n\nRESULTS\nIn 10 of the studies reviewed, the authors came to the conclusion that oscillometric devices were less accurate than auscultatory devices. However, in most cases the oscillometric device appears sufficiently accurate for clinical use, the exceptions being use with hypertensive patients, patients with arrhythmia and after trauma. Only two studies assessed the comparative accuracy of aneroid devices, and these indicated that they were more accurate than oscillometric devices, but the differences were not clinically important.\n\n\nCONCLUSIONS\nThere are situations where the substitution of oscillometric for auscultatory devices could have particularly serious repercussions for the patient, such as when the patient is either hypertensive or hypotensive. However, further research is required on the use of aneroid sphygmomanometers as a replacement for mercury devices.\n\n\nRELEVANCE TO CLINICAL PRACTICE\nPractitioners should be made aware of the need to use auscultatory devices in specific circumstances, such as in management of hypertension, after the patient has experienced trauma or where there is significant potential for deterioration in the patient's condition.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":205329036,"openaccessinfo":{"externalids":{"MAG":"1937811818","ACL":null,"DOI":"10.1111\/j.1365-2702.2010.03528.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The alpha4 integrins, which are constitutively expressed on all human leukocyte subtypes except neutrophils, interact with vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule (MAdCAM-1) on endothelium to mediate selective recruitment of leukocyte subpopulations, other than neutrophils, to sites of inflammation. However, here we report that a different paradigm of leukocyte recruitment may exist in the rat. Flow cytometric analysis of rat neutrophils using a panel of monoclonal antibodies which recognize rat alpha4 and beta1 integrins showed consistent, low levels of expression. Although alpha4 was expressed at lower levels on neutrophils than all other rat leukocytes, this level of expression was sufficient to mediate significant levels of alpha4- and beta1-dependent neutrophil adhesion to rat and human VCAM-1, and alpha4-dependent, but beta1-independent, adhesion to human MAdCAM-1. These data suggest that rat neutrophils, unlike other species, may use alpha4 integrins to traffic to sites of inflammation in vivo.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29102557,"openaccessinfo":{"externalids":{"MAG":"2249687304","ACL":null,"DOI":"10.1182\/BLOOD.V91.7.2341.2341_2341_2346","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract\u2014This paper investigated the simulation of two-phase interleaved boost converter (IBC) with free and open-source software Scilab\/Xcos. By using interleaved method, it can reduce current stress on components, components size, input current ripple and output voltage ripple. The required mathematical model is obtained from the equivalent circuit of its different four modes of operation for simulation. The equivalent circuits are considered in continuous conduction mode (CCM). The average values of the system variables are derived from the state-space equation to find the equilibrium point. Scilab is now becoming more and more popular among students, engineers and scientists because it is open-source software and free of charge. It gives a great convenience because it has powerful computation and simulation function. The waveforms of output voltage, input current and inductors current are obtained by using Scilab\/Xcos.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":54031403,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A method of fabricating a flat type electrochemical device, which is constructed by placing in a case comprising first and second case half bodies a separator and first and second functional substances for an electrochemical device so arranged as to interpose the separator. Peripheral portions of the first and second case half bodies are overlapped with each other, the peripheral portions are welded by a welding process during the application of pressure whereby the peripheral portions are joined with substantially no gaps. The portions welded by the welding process with pressure are then further welded using a laser beam welding.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":141161346,"openaccessinfo":{"externalids":{"MAG":"2932233336","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present thesis, four studies are included within the scientific discipline of pedagogy and collaborative professional development research field\u2014the thesis is based on a practice-based research approach. This thesis addresses identified problems in previous research and large-scale studies such as the OECD study Teaching and Learning International Survey (TALIS) and school leaders' and teachers' attitudes. Furthermore, the need to design teaching that is content-inclusive and accessible to all students. The study's overall question is: What factors of importance for promoting content-inclusive teaching emerge in the studies? Since the thesis aims to contribute with knowledge of how collaborative professional efforts can support teachers' understanding of developing inclusive teaching in the classroom regarding the accessibility of teaching content for all students, the theoretical perspective is motivated by a cultural-historical perspective as an overall theoretical framework. Within the cultural-historical perspective, situated learning and communities of practice (CoP) are in the foreground. The framework of variation theory has been chosen to analyse which teaching content the students are offered to distinguish. The articles used both specific subject content to show how conditions for inclusive teaching can contribute to increased availability of the content knowledge and more comprehensive studies of how teachers' collaborative competence can contribute to increased accessibility. Finally, teachers' perspectives and experiences are in the foreground. The design of the four studies is based on a mixed-methods approach. That means the design of the thesis used qualitative and quantitative methods, both individually and in combination, in the different studies. Since two-year time perspective, it is defined as a longitudinal process. The synthesis describes the factors necessary for promoting content inclusion that has been highlighted in the dissertation studies. Three factors have been identified in the dissertation's results of significance for how collaborative professional efforts can support teachers' understanding of developing inclusive teaching in the classroom regarding the teaching content's accessibility for all students: 1. Development of CoP with a focus on content-inclusive teaching 2. Collaborative professional development that challenges teachers' views on inclusive teaching 3. Analysis of intentional and enacted teaching to identify what is inclusive Within the framework of the studies the dissertation consists of, the results show that the cyclical classroom models, Lesson and Learning study, have contributed to the teachers gaining an in-depth understanding of which aspects have been particularly successful in developing their teaching design. The studies show factors that are important for promoting content-inclusive teachings, such as when the entire teaching team takes collective responsibility for content-focused teaching and is given time for collaborative professional development. Another factor is that teachers are given the opportunity to develop their ability to analyse how teaching can be planned and implemented to identify what contributes to inclusive teaching, where the content and learning situation is put in the foreground. This change has meant a higher focus on the availability of teaching content to all students, compared to a previous focus on individual students' need for special support. The present dissertation results can be seen as a contribution to practicebased professional development research where researchers' and teachers' joint competence is the basis for systematically and structurally approaching the object of learning, thereby reducing the gap between theory and practice.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1,"unknown":2}},"corpusid":251859794,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.24834\/isbn.9789178772773","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.24834\/isbn.9789178772773","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"A p-CuCNS photocathode coated with methyl violet, lightly platinised and then coated with acridine orange was found to be stable in aqueous KI. Photophysics and photochemistry of the mechanism of stabilisation are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250744003,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/19\/9\/005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of the present study was to develop regression models based on ultra-sonographic measurements of fetal eyes (orbital diameter (OD) and eyes volume (EV)) to determine mare gestational age (fetal age) in Arab-Barb breed and to compare the obtained formula with similar formulas used in practice. Twenty-two Arab-Barb mares were included in this study. For each mare, an average of 6 ultrasound examinations per month of gestation, from day 90 of pregnancy to foaling were performed. The parameters examined, OD and EV, were used to establish regression models to determine gestational age of mares. The results led to establish linear regressions of the two parameters, EV and OD. The derived gestational age (GA) prediction formulas were: GA = 0,0097EV + 93,887; GA = 8.687OD + 0.6598 (GA in day; EV in mm3; OD in mm). The coefficients of correlation (R) between EV (R=0.96), OD (R=0.93) and mare gestational age were highly significant (P<0.001) indicating that the two eye measurements can be used to determine accurately mare gestational age after 90 days of pregnancy in Arab-Barb breed. In addition, the formula established in the present work from the OD is more accurate in determining the GA in the Arab-Barb compared to that predefined for English Thoroughbred. This comparison reveals that the growth of fetal orbit of Arab-Barb breed is slower than that of the English Thoroughbred.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245052110,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15835\/buasvmcn-vm:2021.0008","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.15835\/buasvmcn-vm:2021.0008","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Heavy metals pollution had become one of the biggest issue happening in this world and is getting worse each day which could bring adverse effects toward organisms such as plants. Cadmium released to environment through anthropogenic activities such as metal extraction & combustion of fossil fuels whereas nickel is released into the air by power plants and trash incinerators. Plants uptake heavy metals such as cadmium and nickel that are present in the environment which affect their growth or eventually die. This study was carried out to determine the effect of heavy metals namely Cadmium (Cd) and Nickel (Ni) on the seed germination and growth of Extreme Yield Red Chili. Firstly, the seeds were grown in Petri dishes containing different concentrations ranging from 0 to 300 mg\/L of both cadmium (Cd) and nickel (Ni) solution for 14 days. Negative control is prepared by just adding deionized water. All treatments were prepared in 4 replicates. The length of shoots and roots for each treatment were observed and measured at day 7 and day 14. As shown in the results, 0.1 mg\/L and 0.5 mg\/L for Ni concentration did not had massive effect on the growth as both of them had a longer roots and shoots formation which is 1.86 cm and 1.37 cm at day 14. Cd shown the similar results which 0.1 mg\/L and 0.5 mg\/L had the longest length of roots and shoots which is 3.6 cm and 2.7 cm at day 14. The germination percentage was also calculated at day 7 and day 14 and the results showed that Ni had a 100% of seed germination when the concentration was at 1, 50 and 150 mg\/L while Cd concentration at 1 mg\/L. In conclusion, Ni and Cd were not able to affect the seed germination but could affect the growth of shoots and roots","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":104402794,"openaccessinfo":{"externalids":{"MAG":"2909383293","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The function of supervision is to make people safe, quality practitioners. They feel able to do the job to the best of their ability and to give their clients the maximum service they can within a cost-effective system and the confines of their service delivery. (Ormond, 2004)\nSupervision is an activity that, when effective, contributes significantly to service delivery and the ongoing learning and development of staff. Conversely, an organisation dedicating considerable time to an activity that is not benefiting practitioners and clients actually detracts from direct service provision. A national supervision project was commenced in October 2004 to maximise the effectiveness of supervision in the Ministry of Education \u2013 Special Education (GSE). One of the goals of this project was to develop a national supervision framework outlining thekey indicators of effective supervision.\nA reference group was formed of thirteen staff spread across regions, tiers of the organisation, occupational groups and cultural perspectives, as well as extent of experience with GSE and with supervision. The group took an evidence-based approach to the project, with the term \"supervision\" encompassing professional, clinical and cultural supervision. This evidence-based approach was conceptualised as the intersection between the research evidence, practitioner expertise and the lived experiences of the people involved. Therefore, information was gathered from three main sources: a literature review (the research evidence), interviews with twelve luminaries in the field of supervision (practitioner expertise) and an internal online survey (the lived experience of the people involved). Additionally, reference group members scoped existing supervision practices in their districts and regions.\nThe online survey, which had a response rate of nearly 40 percent, gathered a variety of quantitative and qualitative information on the current practices of staff in relation to supervision. Results from the survey, enhanced with information from districts, were used to develop a snapshot of supervision within the organisation. This snapshot was examined against the effective practices outlined by the literature and key luminaries, and informed the development of GSE's national supervision framework.\nThis article seeks to synthesise the evidence underpinning each of the key themes, examine them against the current picture of supervision with GSE and translate them into practical ways of enriching supervision practices.\nSupervision helps a person reach their highest potential in their work and personal life. (Ormond, 2004)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145045257,"openaccessinfo":{"externalids":{"MAG":"233980017","ACL":null,"DOI":"10.54322\/kairaranga.v6i2.31","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/www.kairaranga.ac.nz\/index.php\/k\/article\/download\/31\/19","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Herein, we report controlled protein adsorption and delivery of thermo- and pH-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels at different temperatures, pH values and ionic strengths by employing bovine serum albumin (BSA) as a model protein. For these dual-responsive microgels, we found that the BSA adsorption was driven by several of six competing contributions, viz., physical diffusion (PD), hydrophobic interactions (HI), electrostatic attraction (EA), hydrogen bonding (HB) and temperature or pH-induced seizing action (SAT or SApH), depending on the temperature and pH of the solution. Compared to the pure PNIPAM microgels, the higher swelling degree of the PNIPAM-co-MAA microgels allowed a large amount of BSA loading under any experimental conditions. A largest BSA adsorption of 45.1 \u03bcg mg-1 was achieved at 40 \u00b0C and pH 4 due to the presence of all six contributions. The BSA adsorption and delivery could be further tuned by changing the crosslinking density within the microgels. The BSA binding onto the microgels was found to be ionic strength dependent, which could be attributed to the charge shielding of Na+ ions, salting out of BSA and aggregate formation of the microgels. The adsorbed BSA could be controllably released by adjusting the temperature and pH of the experiment, and with the help of sodium dodecyl sulphate (SDS) addition so as to eliminate each interaction between BSA and the microgels. Thus, this study can be useful to design a stimuli-responsive microgel-based carrier for controlled release of proteins.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238581386,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1039\/d1sm01197a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Double cusps have been observed on a few occasions by polar orbiting spacecraft and ground-based observatories. On 7 Aug. 2004, Cluster 4 was moving poleward through the Northern cusp, followed by Cluster 1, Cluster 2, and finally Cluster 3. The Wind spacecraft detected a Southward turning of the Interplanetary Magnetic Field (IMF) at the beginning of the cusp crossings and IMF-Bz stayed negative throughout. Cluster 4 observed a high energy step in the ion dispersion around 1 keV on the equatorward side of the cusp. Cluster 1, entering the cusp around 1 minute later, did not observe the high energy step anymore but a partial dispersion with a low energy cut-off reaching 100 eV. About 9 minutes later, Cluster 3 entered the cusp and observed full ion dispersion from a few keV down to around 50 eV. All spacecraft observed a less structured and strong ion precipitation region in the centre of the cusp. The flow deduced from the ion distributions was directed poleward and Eastward in the step\/dispersion, whereas in the centre of the cusp, the ion and electron fluxes were higher and the flow was directed mainly westward. This event could be explained by the onset of dayside reconnection when the IMF turned southward. The step would be the first signature of component reconnection, and the injection in the centre of the cusp be produced by anti-parallel reconnection in the northern dusk flank. A three-dimensional magnetohydrodynamic (MHD) simulation is used to help us to locate the sources of the ions and the topology of the magnetic field during the event.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":118287905,"openaccessinfo":{"externalids":{"MAG":"1637866139","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Advances of high-throughput experimental techniques have generated large amounts of gene expression data. Biologically meaningful dynamic structures are expected to be hidden in these data, which are important for understanding the mechanism of cellular activities and identifying the function of genes. In this paper, a novel scheme is presented to reveal the dynamics of gene expression. State-Space Model(SSM) is developed based on the modern control theory. Based on the decomposition of functional modules, an effective strategy is designed to determine the SSM's parameters. Via SSM, gene expression dynamics can be well revealed. To validate our approach and demonstrate its application, numerical experiments are designed by using cell cycle-regulated gene data sets of Yeast Saccharomyces cerevisiae.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1}},"corpusid":1492006,"openaccessinfo":{"externalids":{"MAG":"1985106501","ACL":null,"DOI":"10.1109\/ITCS.2009.290","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nOilseeds and their related products are known to have various bioactive and health-promoting ingredients. In this research, we investigated the effects of phytosterols and fatty acids of Pistacia vera on spermatogenesis process and testis histological changes in Wistar male rats for the first time.\n\n\nMATERIALS AND METHODS\nA total number of 64 adult male Wistar rats were divided randomly into eight groups including one control group, and seven test groups. Test groups received phytosterols, fatty acids, and pistachio oil orally for 30 days. Then, LH, FSH and serum testosterone levels were determined. Also, the spermatogenesis process and changes in testicular tissue in rats were investigated.\n\n\nRESULTS\nThe results of this research suggest that phytosterols in doses 10 and 50 mg\/kg reduce spermatogenesis process. Fatty acid in a low dose of 10 mg\/kg increases spermatogenesis, but when a high dose of 50 mg\/kg was used, it harmed the spermatogenesis process. When low levels of phytosterols and fatty acids are used simultaneously in dose 5 mg\/kg, improvement in spermatogenesis process is observed but when these were used together in the dose of 25 mg\/kg, the spermatogenesis process was disrupted. Using pistachio oil alone also improved spermatogenesis process.\n\n\nCONCLUSION\nIt seems that phytosterols reduce spermatogenesis at high and low doses, while fatty acids increase spermatogenesis when used in low doses and reduce this process when used in high doses. The use of fatty acids extracted from pistachios to treat infertility in men seems hopeful.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263487467,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.22037\/uj.v18i.6605","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nThe pentavalent rotavirus vaccine has been registered in Russia, however, the vaccination coverage remains low, and an annual increase in the incidence of rotavirus infection is unavoidable. In this regard, molecular monitoring of rotaviruses in order to search for new variants possessing epidemic potential is an urgent task.\n\n\nMATERIAL AND METHODS\nPCR genotyping and VP4 and VP7 genes sequencing were used to characterize rotaviruses circulating in Nizhny Novgorod in 2012-2020. The phylogenetic analysis of the strains was carried out using the BEAST software package.\n\n\nRESULTS\nThe spectrum included 17 genotypes with predominance of G9P[8] (37,4%). Detected in this study genotypes G1P[4], G1P[9], G2P[8], G4P[4], G4P[6], G8P[8], and G9P[4] were not previously identified in Nizhny Novgorod. The circulation of DS-1-like strains possessing genotypes G1P[8], G3P[8], G8P[8], or G9P[8] and a short RNA pattern had been shown. Rotaviruses of the common genotypes were genetically heterogeneous and belonged to different phylogenetic lineages and\/or sublineages (P[4]-IV-a; P[4]-IV-b; P[8]-3.1; P[8]-3.3; P[8]-3.4 and P[8]-3.6; G1-I; G1-II; G2-IVa-1; G2-IVa-3; G3-1; G3-3; G4-I-c; G9-III; G9-VI).\n\n\nDISCUSSION\nThese results extend the available data on the genotypic structure of rotavirus populations in Russia and show the genetic diversity of viral strains. G3P[8] DS-1-like viruses were representatives of the G3-1 lineage, new for the territory of Russia, and had the largest number of amino acid substitutions in the VP7 antigenic epitopes.\n\n\nCONCLUSION\nThe emergence and spread of strains with new genetic features may allow rotavirus to overcome the immunological pressure formed by natural and vaccine-induced immunity, and maintain or increase the incidence of rotavirus infection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234746626,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.36233\/0507-4088-46","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/virusjour.crie.ru\/jour\/article\/download\/498\/314","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Microdeletions of Y chromosomes frequently occur in 3 subregions of the AZF, namely, AZFa, AZFb, and AZFc, with 6 basic STS marker sequences, which are sY84, sY86 (AZFa), sY127, sY134 (AZFb), and sY254, sY255 (AZFc). According to EAA\/EMNQ guidelines, 11 additional AZFabc marker sequences should be used to determine the extent of the microdeletion in the AZF region of infertile men, which is known as 11 extended STSs. By applying mPCR, the authors develop an optimal detection procedure for the 6 basic STS and 11 extended STS using 3 multiplex PCR reactions. The first multiplex PCR reaction includes 6 basic STS plus the 2 control sequences sex-determining region Y (SRY) and zinc finger protein X\/Y-linked (ZFX\/Y). The second multiplex PCR reaction includes the 6 extended STS sY88, sY1182, sY105, sY121, sY1191, and sY1291 and the 2 control sequences SRY and ZFX\/Y. The third multiplex PCR reaction includes the 5 extended STS sY153, sY160, sY82, sY143, and sY83 and the 2 control sequences SRY and ZFX\/Y. Six basic primer sequences and eleven extended primer sequences are redesigned to simultaneously pair and amplify STS in the same multiplex reaction: set of 8 primers for 6 basic STS: 6 basic STS + 2 (SRY, ZFX\/Y), 8 extension primers set E1: 6 extended STS + 2 (SRY, ZFX\/Y), and 7 extension primers set E2: 5 extended STS + 2 (SRY, ZFX\/Y). We successfully designed primer pairs with high specificity and stability and successfully amplified 6 basic STS and 11 extended STS, which ensures that the STSs have the correct sequence as recommended by EAA\/EMQN and are consistent with the NCBI gene bank. This study has successfully developed a procedure to simultaneously detect 17 STSs, including 6 basic STSs and 11 extended STSs in the AZF region using 3 multiplex PCR reactions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":239166738,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.31276\/vjste.63(3).48-55","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.31276\/vjste.63(3).48-55","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We propose to achieve the proof-of-principle of the PTOLEMY project to directly detect the Cosmic Neutrino Background (CNB). Each of the technological challenges described in [1,2] will be targeted and hopefully solved by the use of the latest experimental developments and profiting from the low background environment provided by the LNGS underground site. The first phase will focus on the graphene technology for a tritium target and the demonstration of TES microcalorimetry with an energy resolution of better than 0.05 eV for low energy electrons. These technologies will be evaluated using the PTOLEMY prototype, proposed for underground installation, using precision HV controls to step down the kinematic energy of endpoint electrons to match the calorimeter dynamic range and rate capabilities. The second phase will produce a novel implementation of the EM filter that is scalable to the full target size and which demonstrates intrinsic triggering capability for selecting endpoint electrons. Concurrent with the CNB program, we plan to exploit and develop the unique properties of graphene to implement an intermediate program for direct directional detection of MeV dark matter [3,4]. This program will evaluate the radio-purity and scalability of the graphene fabrication process with the goal of using recently identified ultra-high radio-purity CO2 sources. The direct detection of the CNB is a snapshot of early universe dynamics recorded by the thermal relic neutrino yield taken at a time that predates the epochs of Big Bang Nucleosynthesis, the Cosmic Microwave Background and the recession of galaxies (Hubble Expansion). Big Bang neutrinos are believed to have a central role in the evolution of the Universe and a direct measurement with PTOLEMY will unequivocally establish the extent to which these predictions match present-day neutrino densities.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119362633,"openaccessinfo":{"externalids":{"MAG":"2885780362","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1808.01892"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"After rapid changes in social policy and increases in social expenditures over the past five years, many of the uniformly negative assessments of China's record on health care, retirement pensions, and other forms of social security have to be reconsidered. This article examines the rapid expansion in social policy coverage and spending, and considers the possible significance of these changes for Chinese politics. The administrative and territorial categories that have defined access to social welfare provision over the history of the People's Republic of China have not yet receded, but their significance has diminished with programs that create uniform eligibility across rural and urban categories of citizenship. Large gaps in benefits remain, and are likely to generate political demands in the future as urbanization continues to erode the administrative distinctions between urban and rural.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":57572125,"openaccessinfo":{"externalids":{"MAG":"2113814141","ACL":null,"DOI":"10.1162\/DAED_a_00273","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Over the past two decades, helioseismology has revolutionized our understanding of the interior structure and dynamics of the Sun. Asteroseismology will soon place this knowledge into a broader context by providing structural data for hundreds of Sun\u2010like stars. Solar\u2010like oscillations have already been detected from the ground in several stars, and NASA's Kepler mission is poised to unleash a flood of stellar pulsation data. Deriving reliable asteroseismic information from these observations demands a significant improvement in our analysis methods. We report the initial results of our efforts to develop an objective stellar model\u2010fitting pipeline for asteroseismic data. The cornerstone of our automated approach is an optimization method using a parallel genetic algorithm. We describe the details of the pipeline and we present the initial application to Sun\u2010as\u2010a\u2010star data, yielding an optimal model that accurately reproduces the known solar properties.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16303676,"openaccessinfo":{"externalids":{"MAG":"1557181960","ACL":null,"DOI":"10.1063\/1.3246558","PubMedCentral":null,"ArXiv":"0906.4317"},"license":null,"url":"http:\/\/arxiv.org\/pdf\/0906.4317v1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The purpose of the ASME\/DOE Gen IV Task 7 Part I is to review the current experience on various high temperature reactor intermediate heat exchanger (IHX) concepts. There are several different IHX concepts that could be envisioned for HTR\/VHTR applications in a range of temperature from 850C to 950C. The concepts that will be primarily discussed herein are: (1) Tubular Helical Coil Heat Exchanger (THCHE); (2) Plate-Stamped Heat Exchanger (PSHE); (3) Plate-Fin Heat Exchanger (PFHE); and (4) Plate-Machined Heat Exchanger (PMHE). The primary coolant of the NGNP is potentially subject to radioactive contamination by the core as well as contamination from the secondary loop fluid. To isolate the radioactivity to minimize radiation doses to personnel, and protect the primary circuit from contamination, intermediate heat exchangers (IHXs) have been proposed as a means for separating the primary circuit of the NGNP (Next Generation Nuclear Plant) or other process heat application from the remainder of the plant. This task will first review the different concepts of IHX that could be envisioned for HTR\/VHTR applications in a range of temperature from 850 to 950 C. This will cover shell-and-tube and compact designs (including the platefin concept). The review will then discuss the maturitymore\u00a0\u00bb of the concepts in terms of design, fabricability and component testing (or feedback from experience when applicable). Particular attention will be paid to the feasibility of developing the IHX concepts for the NGNP with operation expected in 2018-2021. This report will also discuss material candidates for IHX applications and will discuss specific issues that will have to be addressed in the context of the HTR design (thermal aging, corrosion, creep, creep-fatigue, etc). Particular attention will be paid to specific issues associated with operation at the upper end of the creep regime.\u00ab\u00a0less","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":109875549,"openaccessinfo":{"externalids":{"MAG":"1546099191","ACL":null,"DOI":"10.2172\/974284","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/servlets\/purl\/974284","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We have previously reported the phenotypic characterization of methicillin\u2010resistant Staphylococcus aureus (MRSA) clinical strains isolated in Malaya University Hospital in the period 1987 to 1989 using antibiogram, coagulase typing, plasmid profiles, and phage typing. Here, we report the analysis of the same strains with three genotyping methods; ribotyping, pulsed\u2010field gel electrophoresis (PFGE) typing, and IS431 typing (a restriction enzyme fragment length polymorphism analysis using an IS431 probe). Ribotyping could discriminate 46 clinical MRSA strains into 5 ribotypes, PFGE typing into 22 types, and IS431 typing into 15 types. Since the differences of the three genotyping patterns from strain to strain were quite independent from one another, the combined use of the three genotyping methods could discriminate 46 strains into 39 genotypes. Thus, the powerful discriminatory ability of the combination was demonstrated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43113353,"openaccessinfo":{"externalids":{"MAG":"1992466746","ACL":null,"DOI":"10.1111\/j.1348-0421.1997.tb01912.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/j.1348-0421.1997.tb01912.x","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In machining process, the machine, cutting and the work piece are integrated to form structural \nsystems which create a dynamic characteristic. Soliman, Ismail [1] observed that vibration can \nbe divided into three types, free vibrations, force vibrations and self-excited vibrations (chatter). \nAs in this project, the focus is more on the chatter that contribute for the tool wear during the \nmachining of material under certain conditions of cutting processes. Chatter is an abnormal tool \nbehavior which it is one of the most critical problems in machining process and must be avoided \nto improve the dimensional accuracy and surface quality of the product. Chatter is originated \nfrom the disturbance that occur in the cutting zone to lack of homogeneity between surface of the \nwork piece, change in the types chips being produced or change in the frictional conditions at the \ntool-chip interface influenced by cutting fluids being used. The forces then strain the structure \nelastically and can cause a relative displacement between tool and work piece. The theory of \nchatter quoted by Budak, E, and Altintas Y. [2,3] suggested the chatter as a coupling \nvibration phenomenon between the workpiece and tool. Wiercigrocch M. and Budak [4] \nstates that mode of coupling resulted from the vibration in the thrust force direction \ngenerate vibration in the thrust and cutting force direction. However, Amin and Anayet [5] \nfound that the root cause of chatter lies in the coincidence of the frequency of instability of chip \nformation with one of the natural frequencies of the machine-spindle-tool system components \nduring end milling machining operation. \nKim et al. [6] explained that most of the drawbacks that come from chatter are excessive \ntool wear, noise, tool breakage, and deterioration of the surface quality. Moreover chatter \nalso results in reduced material removal rate (MRR), increased costs in terms of time, \nmaterials and energy, as well as the environmental impact of dumping non-valid final \nparts and having to repeat the manufacturing process as quoted from Quintana et al. [7]. The chatter phenomenon actually can be suppressed by some of methods. Nakagawa et al \n[8] showed that end mill with different helix angles could prevent generative chatter \nvibration at lower cutting speeds and was also effective in suppressing chatter vibration at \nhigher cutting speed. On the other hand, a laser Doppler vibrometer has recently been \ndeveloped to observe such high frequency vibration phenomena. Furthermore, a fuzzy \nlogic approach for chatter suppression in end milling process is discussed by M. Liang, T. \nYeap and A. Hermansyah [9]. Chatter is detected using the peak sound spectrum \namplitudes at chatter frequency ranges. For this research, the study is mainly focused to \ninvestigate the chatter amplitude effect on surface roughness at various cutting conditions with \nduring end milling operation of medium carbon steel.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107268061,"openaccessinfo":{"externalids":{"MAG":"165273472","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this review paper is to update the current and potential future role of probiotics for Clostridium difficile-associated disease (CDAD). Included in this review, is an update on the testing of newer probiotics (e.g., Bacillus coagulans GBI-30, 6086) in animal models of CDAD. There is a focus on the modulation of signal transduction pathways (i.e., transcription factors like cAMP response element-binding, activator protein 1, and nuclear factor kappa B), as well as the inhibition of certain kinases (e.g., p38 mitogen activated protein kinases) by probiotics. Inhibition of signal transduction by probiotics, such as Saccharomyces boulardii, result in multiple effects on intestinal fluid secretion, neutrophil influx into the colon, inflammation, and colonocyte apoptosis that may positively impact CDAD. Recent clinical approaches with probiotics, for the prevention of primary and recurrent CDAD, are also summarized in this review paper. Future directions for the treatment of CDAD by probiotics are also mentioned in this review. In particular, the use of multi-strain probiotic formulations such as Ecologic(\u00ae) AAD and VSL #3(\u00ae) may represent a rationale pharmacological approach, particularly as adjunctive therapies for CDAD. Understanding the mechanistic basis of CDAD, and how probiotics interfere at ceratin steps in the pathogenic process, may also present the opportunity to design other multi-strain probiotics that could have a future impact on CDAD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1206677,"openaccessinfo":{"externalids":{"MAG":"1992643331","ACL":null,"DOI":"10.4291\/wjgp.v4.i3.47","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4291\/wjgp.v4.i3.47","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"When imperative (value- or state-oriented) programming and logical (relation-oriented) programming are combined into a single language, the combination is even more powerful than when either technique is used alone. Leda, a strongly typed compiled language that tries to combine features of both, is described. Suggestions for blending the two styles are offered. Logical features of Leda are examined.<>","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-06":1,"unknown":2}},"corpusid":6472564,"openaccessinfo":{"externalids":{"MAG":"2046881171","ACL":null,"DOI":"10.1109\/52.62933","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Numerous technologic advances have greatly facilitated the noninvasive analysis of right ventricular function. Nevertheless, important clues continue to be available to the astute clinician by physical examination. The chest x-ray is of rather limited utility. The electrocardiogram can show evidence of right atrial enlargement or right ventricular hypertrophy. Unfortunately, both sensitivity and specificity are deficient. Echocardiography is a widely available and potentially very accurate source of information concerning right ventricular dysfunction. Careful temporal analysis of the M-mode echocardiogram can give information beyond chamber size and wall thickness. Two-dimensional echocardiography allows more accurate determination of chamber size and wall thickness and also permits analysis of segmental wall motion and chamber contour. Doppler echocardiography allows measurement of pressure differences and flow kinetics. Preliminary data indicate that one can accurately assess pulmonary artery pressure and possibly right ventricular diastolic function. Color-flow mapping allows for accurate determination of valvular regurgitation and enhances the accuracy of standard Doppler echocardiographic techniques. Radionuclide analysis of the right ventricle by blood-pool imaging allows accurate determination of ejection fraction and wall motion. In addition, it may be possible to estimate pulmonary artery pressure. Use of short-acting radionuclides allows for serial imaging of the right ventricle after pharmacologic intervention or exercise. Perfusion scanning can show evidence of exercise-induced ischemia, although applicability to the right ventricle is somewhat limited. Avid scanning allows localizing of myocardial injury to the right ventricle. CT scanning of the heart is of limited clinical utility, because cardiac motion occurs too rapidly for accurate imaging. The advent of the cine-CT may overcome this problem and allow evaluation of right ventricular volumes and wall motion. Digital subtraction imaging allows for accurate video densitometric calculation of ejection fractions, but offers no advantage over other currently available techniques. Magnetic resonance imaging may prove to be the methodology of choice for analysis of right ventricular function, because it can give accurate measurement of right ventricular wall motion, ejection fraction, and (similar to Doppler flow studies) some indication of flow within the right-sided chambers. It will soon be possible to generate information concerning the biochemical content of the right ventricular myocardium, perhaps providing early evidence of hypertrophy or myopathy.(ABSTRACT TRUNCATED AT 400 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":77589774,"openaccessinfo":{"externalids":{"MAG":"2417008697","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present years, population of vehicles increased enormously which increases the demand of fossil fuel, The availability of conservative fuels decreased continuously, these reasons makes to find the alternative fuels especially biofuels . The use of biodiesel considerably reduced emission and increase the performance of the engine. Now a days researchers have reported the possibility for the production of biodiesel from non edible oil jatropha curcus , pongamia pinnata etc. There is a best source of raw material that is calophyllum inophyllum oil for biodiesel production. In present study calophyllum inophyllum is used as fuel in C.I engine.Blends such as CIME10, CIME20, CIME30, CIME100 are taken for the experiment From this blends CIME20 gives good results and for this blend Isobutanol is added as fuel additive with concentration of 10%,15%. The Performance was improved and emissions were reduced by using Isobutanol with CIME20. ---------------------------------------------------------------------***---------------------------------------------------------------------","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":221838124,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The CMS experiment recorded 177.75 fb\u22121 of proton-proton collision data during the RUN-1 and RUN-2 data taking period. Successful data taking at increasing instantaneous luminosities with the evolving detector configuration was a big achievement of the collaboration. The CMS RPC system provided redundant information for the robust muon triggering, reconstruction, and identification. To ensure stable data taking, the CMS RPC collaboration has performed detector operation, calibration, and performance studies. Various software and related tools are developed and maintained accordingly. In this paper, the overall performance of the CMS RPC system and experiences of the data taking during the RUN-2 period are summarised.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2,"unknown":2}},"corpusid":218889841,"openaccessinfo":{"externalids":{"MAG":"3038926557","ACL":null,"DOI":"10.1088\/1748-0221\/15\/10\/C10027","PubMedCentral":null,"ArXiv":"2005.12532"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Hiking is a demanding form of exercise that may cause delayed responses of the postural muscles and a loss of somatosensory information, particularly when repeatedly performed for several days. These effects may negatively influence the postural control of hikers. Therefore, the aim of this study was to investigate the effects of a four-day hike on postural control. Twenty-six adults of both sexes travelled 262 kilometers, stopping for lunch and resting in the early evening each day. Force platforms were used to collect center of pressure (COP) data at 100 Hz for 70 seconds before hiking started and immediately after arriving at the rest station each day. The COP time course data were analyzed according to global stabilometric descriptors, spectral analysis and structural descriptors using sway density curve (SDC) and stabilometric diffusion analysis (SDA). Significant increases were found for global variables in both the anterior-posterior and medial-lateral directions (COP sway area, COP total sway path, COP mean velocity, COP root mean square value and COP range). In the spectral analysis, only the 80% power frequency (F80) in the anterior-posterior direction showed a significant increase, reflecting the increase of the sway frequencies. The SDC revealed a significant increase in the mean distance between peaks (MD) and a significant decrease in the mean peak amplitudes (MP), suggesting that a larger torque amplitude is required for stabilization and that the postural stability is reduced. The SDA revealed a decrease in the long-term slope (Hl) and increases in the short-term (Ks) and the long-term (Kl) intercepts. We considered the likelihood that the presence of local and general fatigue, pain and related neuromuscular adaptations and somatosensory deficits may have contributed to these postural responses. Together, these results demonstrated that four days of hiking increased sway frequencies and deteriorated postural control in the standing position.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17938575,"openaccessinfo":{"externalids":{"MAG":"2010704857","ACL":null,"DOI":"10.1371\/journal.pone.0123214","PubMedCentral":"4406731","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0123214&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper looks at the history of game industry platforms in Finland and Sweden between 1979 and 2020 via 745 games. Both are relatively small countries where developers perform exceptionally well in a global market context. Developers and games developed in both countries are rather similar with some notable differences: Finnish developers focused on mobile games on Symbian in the 2000s, whereas Swedish developers focused on PC and console games, continuing a PC focus during the 2010s. The number of game companies has increased rapidly in Finland and Sweden since 2010 but peaked in Finland in 2014. From a platform studies perspective our data highlights rewarding historical insights about the dynamics of game industry platforms in Finland and Sweden with dimensions such as influence by demo scene, price of hardware\/software (computers), mathematics education, third-party game engines, and finally higher education programmes in game development, consequently framing the data in socio-material perspectives on game industry platforms as application ecologies.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2}},"corpusid":258051063,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1145\/3582437.3587214","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3582437.3587214","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Titan, after Venus, is the second example in the solar system of an atmosphere with a global cyclostrophic circulation, but in this case a circulation that has a strong seasonal modulation in the middle atmosphere. Direct measurement of Titan's winds, particularly observations tracking the Huygens probe at 10 deg S, indicate that the zonal winds are mostly in the sense of the satellite's rotation. They generally increase with altitude and become cyclostrophic near 35 km above the surface. An exception to this is a sharp minimum centered near 75 km, where the wind velocity decreases to nearly zero. Zonal winds derived from temperatures retrieved from Cassini orbiter measurements, using the thermal wind equation, indicate a strong winter circumpolar vortex, with maximum winds of 190 m\/s at mid northern latitudes near 300 km. Above this level, the vortex decays. Curiously, the stratospheric zonal winds and temperatures in both hemispheres are symmetric about a pole that is offset from the surface pole by about 4 deg. The cause of this is not well understood, but it may reflect the response of a cyclostrophic circulation to the onset between the equator, where the distance to the rotation axis is greatest, and the seasonally varying subsolar latitude. The mean meridional circulation can be inferred from the temperature field and the meridional distribution of organic molecules and condensates and hazes. Both the warm temperatures near 400 km and the enhanced concentration of several organic molecules suggest subsidence in the north polar region during winter and early spring. Stratospheric condensates are localized at high northern latitudes, with a sharp cut-off near 50 deg N. Titan's winter polar vortex appears to share many of the same characteristics of isolating high and low-latitude air masses as do the winter polar vortices on Earth that envelop the ozone holes. Global mapping of temperatures, winds, and composition in the troposphere, by contrast, is incomplete. The few suitable discrete clouds that have been found for tracking indicate smaller velocities than aloft, consistent: with the Huygens measurements, Along the descent trajectory, the Huygens measurements indicate eastward zonal winds down to 7 km, where they shift westward, and then eastward again below 1 km dawn to the surface. The low-latitude dune fields seen in Cassini RADAR images have been interpreted as longitudinal dunes occurring in a mean eastward zonal wind. This is not like Earth, where the low-latitude winds are westward above the surface. Because the net zonal-mean time-averaged torque exerted by the surface on the atmosphere should vanish, there must be westward flow over part of the surface; the question is where and when. The meridional contrast in tropospheric temperatures deduced from radio occultations at low, mid, and high latitudes. is small, approximately 5 K at the tropopause and approximately 3 K at the surface. This implies efficient heat transport, probably by axisymmetric meridional circulations. The effect of the methane \"hydrological\" cycle on the atmospheric circulation is not well constrained by existing measurements, Understanding the mature of the surface-atmosphere coupling will be critical to elucidating the atmospheric transports of momentum, heat, and volatiles.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":126898742,"openaccessinfo":{"externalids":{"MAG":"779171789","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Maillard reaction products (MRPs) are widely consumed as a part of the human diet. A 2 week randomised two-period crossover trial to determine whether MRP intake affects the antioxidant defence system in male adolescents (11\u201314 years, n = 18) was carried out using two diets rich and poor in MRPs (brown diet, BD, and white diet, WD, respectively). Fasting blood samples were collected after the dietary intervention periods to measure oxidative status. The in vitro antioxidant activity of the diets was also assessed. RESULTS: The BD had stronger in vitro antioxidant activity to scavenge free radicals and greater ability to reduce lipid peroxidation. However, in the in vivo assay, markers of oxidative damage (serum thiobarbituric acid-reactive substances and erythrocyte hydroperoxides) and antioxidant defence parameters (serum antioxidants and enzymatic activities of catalase, superoxide dismutase and glutathione peroxidase) were unchanged after the dietary treatments. Only treatment of biological samples with external oxidants revealed higher values of the antioxidant capacity after consumption of the MRP-rich diet. CONCLUSION: In spite of the higher antioxidant activity of the BD shown in vitro, consumption of diets rich in MRPs does not seem to modify oxidative status in healthy male adolescents. However, a protective effect against induced oxidation was shown. Copyright \u00a9 2008 Society of Chemical Industry","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":84548885,"openaccessinfo":{"externalids":{"MAG":"2044058366","ACL":null,"DOI":"10.1002\/JSFA.3213","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effects of feeding system (indoor vs rangeland) and olive-cake (OC) supplementation (control vs supplemented) on fatty acid (FA) composition, lipid oxidation status and meat-colour stability were studied. Lambs were fed indoor with hay (OH) or reared on improved rangeland (RL). All lambs received concentrate at a rate of 400 g\/head.day. Twenty-four 6-month-old Barbarine lambs with an average weight of 24.3 \u00b1 1.1 kg were assigned into the following four groups: OH without OC, OH with OC, RL without OC and RL with OC. Supplemented groups received 280 g\/day of OC. Lambs were reared for ~3 months and then slaughtered at 33 kg. Feeding lambs on rangeland increased proportions of polyunsaturated fatty acids (PUFA, P < 0.05), n-3 PUFA (P < 0.01) and long-chain n-3 PUFA (P < 0.01) and decreased those of C16:0 and monounsaturated fatty acids (P = 0.052). Higher PUFA\u2009:\u2009saturated FA (SFA) (P < 0.001) and lower n-6\u2009:\u2009n-3 PUFA (P < 0.01) ratios were found for RL lambs. The peroxidisability index was higher (P = 0.024) for RL lambs. Whereas, a lower malondialdehyde concentration (P < 0.001) was found for meat of RL group after 5-day storage, because of a higher vitamin E concentration (P < 0.001) and catalase activity (P\u2009=\u20090.002). Moreover, colour was more stable for meat of RL lamb. OC supplementation reduced only superoxide dismutase activity (P\u2009=\u20090.033) and did not have any effect on lipid peroxidation and colour stability. No interactions were noted between the feeding system and olive-cake supplementation. Meat lambs produced on rangeland had a healthier fatty acid composition. Lipids were more stable to oxidation than was meat produced indoor with hay and concentrate.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":89860909,"openaccessinfo":{"externalids":{"MAG":"2603738634","ACL":null,"DOI":"10.1071\/AN16352","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Skid mounted surface pipelines have been used to cross four major creek valleys on the Westcoast Energy 762 mm Fort Nelson mainline where very large deep-seated slides are progressively failing. The surface pipeline segments range up to 2.2 km long and were used to cross very large slides on the creek approach slopes, or in one case, down valley sliding of the valley floor, which had resulted in major operational problems for the originally buried pipelines. The surface pipeline segments were used for slides where there were no other options for a conventional buried pipeline. During the studies to support the design of the surface pipelines, comprehensive geotechnical investigations included drilling, installation of slope indicators, and electric piezocone penetrometer testing to monitor subsurface pore water pressures and to detect deep seated slide surfaces. Typical peak movement rates of the slides varied to a maximum of several meters per year. The unstable soils were predominantly medium to high plastic silty clay tills and high plastic glaciolacustrine clays with residual internal angles of friction of 7.5 to 8.5\u00b0.The pipelines were placed on pressure treated timber skids on graded rights-of-ways (RoW) with comprehensive surface and subsurface water control. Aerial clear span crossings were used across the watercourses with geogrid reinforced abutments on the unstable soil. Geogrids were also used to add stability to structural fills and to reinforce an area of the RoW subject to encroachment from a rapidly moving earth flow up to 6 m deep. The general maintenance and operational guidelines are also discussed. Provincial and Federal regulatory concerns and their abatement are presented and discussed. Over the past five years of operation of the pipelines, one of the slopes moved 1.5 m in a twenty-four hour period and related total movements left a 5 m high head scarp on the RoW. Displacement of soil and areas of thrusting resulted in unsupported pipe spans of 35 m with negligible deleterious impact on the pipeline. This magnitude of movement would have almost certainly caused a failure of the original buried line. All of slopes have continued to move and would have caused a varying magnitude of operational problems had the pipelines still been buried.Copyright \u00a9 1998 by ASME","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":114853906,"openaccessinfo":{"externalids":{"MAG":"2536097756","ACL":null,"DOI":"10.1115\/IPC1998-2019","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 33-year-old male was admitted because of severe neutropenia (55\/microliter) in 1985. A diagnosis of autoimmune neutropenia was not made. CD4+ T-lymphocyte count was 128\/microliter and CD4\/CD8, 0.1, though the titers of immunoglobulins were in normal range. Nine times examinations of CD4+ T-lymphocyte count resulted in 5 times lower counts than 300\/microliter between 1985 and 1993. His HIV (type 1 and type 2) studies were negative. He suffered from EB virus infection in 1987. The titers of VCA-IgG and EA-IgG had been elevated for half a year after that. He was operated polyp-like tumors in bilateral nasal cavities on February in 1994. The diagnosis was Burkitt's lymphoma that was also demonstrated by in situ hybridization using EB virus RNA. He was treated with a modification of COPBLAM III, but he died on June in 1994. Autopsy revealed tumor cell infiltrations in multiple organs. We suspect that he developed Burkitt's lymphoma 82 months later, when he had complicated EB virus infection in condition of idiopathic CD4+ T-lymphocytopenia caused by unknown origin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42996816,"openaccessinfo":{"externalids":{"MAG":"2415089918","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Insight into how H2O is oxidized to O2 is envisioned to facilitate the rational design of artificial water oxidation catalysts, which is a vital component in solar-to-fuel conversion schemes. Herein, we report on the mechanistic features associated with a dinuclear Ru-based water oxidation catalyst. The catalytic action of the designed Ru complex was studied by the combined use of high-resolution mass spectrometry, electrochemistry, and quantum chemical calculations. Based on the obtained results, it is suggested that the designed ligand scaffold in Ru complex 1 has a non-innocent behavior, in which metal\u2013ligand cooperation is an important part during the four-electron oxidation of H2O. This feature is vital for the observed catalytic efficiency and highlights that the preparation of catalysts housing non-innocent molecular frameworks could be a general strategy for accessing efficient catalysts for activation of H2O.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":7714440,"openaccessinfo":{"externalids":{"MAG":"2118082954","ACL":null,"DOI":"10.1002\/chem.201406613","PubMedCentral":"4517172","ArXiv":null},"license":"unspecified-oa","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/chem.201406613","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Agriculture is most dominantly shaping the German environment, providing our basic food resources as well as the sources for bioenergy. This implies an intense societal exposure to the influences brought about by agricultural practices. Hence, a well functioning system of R&D is urgently required as prerequisite for constant and sustainable advancement of the sector. The study will present the structures and resources of the German agricultural research landscape including the most important sponsors, institutes, capacities and foci of agricultural R&D. A special focus will be laid on the field of animal production. It will be evaluated whether current research activities are suitable to provide solutions for contemporary questions and problems in the agricultural sector.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":158693543,"openaccessinfo":{"externalids":{"MAG":"2769212615","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Accumulation of \u03b2-amyloid (A\u03b2) in the brain has been implicated in the pathology of Alzheimer's disease (AD). A\u03b2 is produced from the A\u03b2 precursor protein (APP) through the amyloidogenic pathway by \u03b2-, and \u03b3-secretase. Alternatively, APP can be cleaved by \u03b1-, and \u03b3-secretase, precluding the production of A\u03b2. Thus, stimulating \u03b1-secretase mediated APP processing is considered a therapeutic option not only for decreasing A\u03b2 production but for increasing neuroprotective sAPP\u03b1. We have previously reported that 7-deoxy-trans-dihydronarciclasine (E144), the active component of Lycoris chejuensis, decreases A\u03b2 production by attenuating APP level, and retarding APP maturation. It can also improve cognitive function in the AD model mouse. In this study, we further analyzed the activating effect of E144 on \u03b1-secretase. Treatment of E144 increased sAPP\u03b1, but decreased \u03b2-secretase products from HeLa cells stably transfected with APP. E144 directly activated ADAM10 and ADAM17 in a substrate-specific manner both in cell-based and in cell-free assays. The Lineweaver\u2013Burk plot analysis revealed that E144 enhanced the affinities of A Disintegrin and Metalloproteinases (ADAMs) towards the substrate. Consistent with this result, immunoprecipitation analysis showed that interactions of APP with ADAM10 and ADAM17 were increased by E144. Our results indicate that E144 might be a novel agent for AD treatment as a substrate-specific activator of \u03b1-secretase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":211049789,"openaccessinfo":{"externalids":{"MAG":"3003227861","ACL":null,"DOI":"10.3390\/molecules25030646","PubMedCentral":"7037359","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1420-3049\/25\/3\/646\/pdf?version=1580730750","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Rangelands contain between 10 and 30% of global soil organic C reserves and may be an important sink for atmospheric CO2, but less C tends to be stored in rangelands cultivated for agricultural use than undisturbed rangelands. Establishing perennial plant communities on formerly cultivated rangelands is expected to stabilize soil properties and increase the amount of C stored in rangeland soils, but there is little information on what plant communities are most effective at building soil C reserves. The purpose of this study was to compare soil C, N, and P pools in ungrazed native rangelands with ungrazed, unfertilized rangelands that were cultivated and then 1) abandoned, 2) seeded with non-native perennial grasses or legumes, or 3) cropped annually for 5 to 6 years. Three study sites in southern Alberta, Canada with native Stipa-Bouteloua, Stipa-Bouteloua-Agropyron and Festuca campestris plant communities represented the major ecotypes of the Northern Great Plains. The total C, N, and P content of rangeland soils were greatest at the Festuca campestris site, followed by the Stipa-Bouteloua-Agropyron and Stipa-Bouteloua sites, probably due to climatic conditions (precipitation and temperature). Generally, soils under modified plant communities contained less total C and N than soils under native rangeland, but the total P content was related more to site preparation than experimental treatments. Soils under alfalfa, orchardgrass and bromegrass tended to have more total C and N than soils cultivated annually in continuous wheat or wheat-fallow systems. The accumulation of C and N in soils under permanent cover was not related to net primary productivity and may be influenced more by the chemical composition and rate of decomposition of plant residues. DOI:10.2458\/azu_jrm_v56i6_whalen","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":59939682,"openaccessinfo":{"externalids":{"MAG":"2185600728","ACL":null,"DOI":"10.2458\/AZU_JRM_V56I6_WHALEN","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objective Antilock braking systems (ABS) prevent wheels from locking during hard braking and have been shown to reduce motorcyclists' crash risk. ABS has proliferated in the United States fleet, and the objective of the current study was to update the effectiveness estimate for ABS with additional years of data and a broader variety of motorcycle types. Methods Motorcycle drivers involved in fatal crashes per 10,000 registered vehicle years during 2003\u201319 were examined for 65 motorcycle models offering ABS as an optional feature. Fatal crash rates for motorcycles with ABS were compared with rates for the same models without it. Results ABS was associated with a statistically significant 22% reduction in motorcycle driver fatal crash involvements per 10,000 registered vehicle years. Conclusion This finding adds to the growing literature demonstrating the safety benefits of motorcycle ABS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":2,"2024-26":1}},"corpusid":247616104,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/15389588.2022.2047957","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We examine cash holdings and leverage levels of German listed (non-financial and non-utility) firms. We document a secular increase in cash ratios over the last twenty years (1992\u20132011), reducing the net debt book leverage ratio for the average sample firm close to zero. Using pre-diction models with standard firm characteristics, our results suggest a fundamental change in firms' financial policies: In the second half of the sample period, both established firms and IPO firms exhibit substantially higher (lower) cash (net debt leverage) levels than predicted. The unexpected changes among established firms are associated with measures of uncertainty faced by firms. Our results suggest that German firms have increased (reduced) their cash (net debt leverage) levels over time in order to adopt more precautionary financial policies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":166878993,"openaccessinfo":{"externalids":{"MAG":"169978765","ACL":null,"DOI":"10.2139\/ssrn.2434505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Iteratively reweighted least squares (IRLS) is a widely-used method in machine learning to estimate the parameters in the generalised linear models. In particular, IRLS for L1 minimisation under the linear model provides a closed-form solution in each step, which is a simple multiplication between the inverse of the weighted second moment matrix and the weighted first moment vector. When dealing with privacy sensitive data, however, developing a privacy preserving IRLS algorithm faces two challenges. First, due to the inversion of the second moment matrix, the usual sensitivity analysis in differential privacy incorporating a single datapoint perturbation gets complicated and often requires unrealistic assumptions. Second, due to its iterative nature, a significant cumulative privacy loss occurs. However, adding a high level of noise to compensate for the privacy loss hinders from getting accurate estimates. Here, we develop a practical algorithm that overcomes these challenges and outputs privatised and accurate IRLS solutions. In our method, we analyse the sensitivity of each moments separately and treat the matrix inversion and multiplication as a post-processing step, which simplifies the sensitivity analysis. Furthermore, we apply the {\\it{concentrated differential privacy}} formalism, a more relaxed version of differential privacy, which requires adding a significantly less amount of noise for the same level of privacy guarantee, compared to the conventional and advanced compositions of differentially private mechanisms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":10764136,"openaccessinfo":{"externalids":{"MAG":"2407235586","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1605.07511"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Morphology of microparticles of the microencapsulated measles vaccine was studied by cryofractography, transmission electronic microscopy and by atomic force microscopy; co-polymers of polyacrylic acid and of sodium-alginate (spermidine) complexes were used as the matrix. The different-composition microcapsules had clear-cut borders and a certain range of sizes; but they were different in morphology, and their structures and densities varied identically with regard for a medium acidity, which is apparently preconditioned by some conformation-type alterations of matrix molecules. The studied preparations can, probably, protect the viral material in the stomach aggressive medium and release the material to ensure its contact with the intestine lymph tissue; thereof, they can be referred to as promising for further study of mucosal vaccines.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22316568,"openaccessinfo":{"externalids":{"MAG":"2419527570","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: Damage to Schwann cells play a crucial role in diabetic peripheral neuropathy (DPN) . To observe whether HMGB1 inhibitor (Glycyrrhizic acid, GA) can prevent diabetic Schwann cells damage and its potential mechanisms.\n Methods: RSC96 cells were divided into 5 groups: NG group (5.6 mmol\/L) and HG group (25.0 mmol\/L) , HG+GA (1\u03bcM) group, HG+GA (10\u03bcM) , HG+GA (100\u03bcM) . Small interfering RNA was used to knock out HMGB1. CCK8 assay was used to detect the proliferation of RSC96 cells. The levels of inflammatory factors were determined by ELISA. The mRNA expression of NGF and neuritin-1 was detected by qRT-PCR. The expression levels of NSE, cleaved-caspase-3, RAGE, p38MAPK, ERK, JNK and NF-\u03baBp65 in cells were measured by western blot.\n Results: GA at the concentration of \u03bcM for 24h had significant inhibitory effect on HMGB1 synthesis and secretion (P<0.05) . Schwann cell viability in high glucose was restored due to GA and siHMGB1 (P<0.05) . GA intervention and siHMGB1 potently prevented inflammatory substance generation (TNF-\u03b1, IL-1\u03b2, IL-6, MCP-1 and ICAM-1) , alleviated the neurotrophic factor reduction (NGF and neuritin-1) , and suppressed cellular apoptosis related protein activation (cleaved caspase-3) in Schwann cells exposed to high glucose ambience (P<0.05) . Moreover, we found that RAGE expression, p38MAPK phosphorylation and nuclear NF-\u03baBp65 expression in high glucose-stimulated Schwann cells was reversed by GA or siRNA interference with HMGB1 (P<0.05) .\n Conclusions: GA and siHMGB1 can not only inhibit HMGB1 expression in Schwann cells exposed to high glucose, but also enhance cell viability. GA and siHMGB1 restored neurotrophic factors level and reduce cleaved caspase-3 expression in Schwann cell due to its anti-inflammatory ability, which may be related to the inhibition of RAGE\/p38MAPK\/nuclear NF-\u03baBp65 pathway. HMGB1 may implicate in Schwann cells lesion in high glucose milieu and HMGB1 inhibition protects Schwann cells from high glucose induced cytotoxicity.\n \n \n National Natural Science Foundation of China Grant Award (81700723)","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":249265188,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2337\/db22-456-p","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Direct measurements of hypoxanthine (Hx) in fish flesh were carried out using a sardine and a grunt twice with the same fish, and the average of 10 successive measurements (from 120 sec to 480 sec after pressing the probe against fish tissue) was taken as the Hx concentration by direct measurement. Results with two nearby tissues of one sample were 42.9 \u00b1 4.9 \u03bcM and 42.6 \u00b1 2.6 \u03bcM for the sardine, and 639 \u00b1 33 \u03bcM and 598 \u00b1 29 \u03bcM for the grunt. For sardine, Hx results from this direct method did not agree well with perchloric acid extraction measurements, but they were much better for grunt.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97813315,"openaccessinfo":{"externalids":{"MAG":"2076453892","ACL":null,"DOI":"10.1111\/J.1365-2621.1996.TB12193.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intergenerational correlations of time preference are well documented. However, there is still limited empirical evidence about the role of genetics in this transmission process. In our paper, we use data on roughly 3,000 twins from the German TwinLife project to estimate the heritability of time preference. We rely on an experimentally validated survey measure of temporal discounting, namely, self-assessed patience. The analysis of monozygotic and dizygotic twins enables us to apply standard biometric models. We find that genetic differences explain up to 23 percent of individual variation in patience. Whereas the additive genetic effect and common environmental effects are of minor importance, a major dominant genetic effect is present. These results indicate a notable degree of genetic influence on economic time preferences.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210990461,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"3D real-time acquisition plays a vital role in computer graphics and computer vision. In this paper, we present a dynamic IR structured light sensing system with high resolution and accuracy for real-time 3D scanning. We adopt the Gray code combined with stripe shifting as our 3D acquisition's coding strategy and parallelize the algorithm via the GPU in our IR 3D scanning system. Our built-up system can capture dense and high-precision 3D model sequences with a speed of 29 Hz. Furthermore, we propose a practical calibration method to obtain accurate calibration parameters for our system. Finally, various experiments are performed to verify the feasibility and accuracy of our proposed IR structured light sensing system.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":218814473,"openaccessinfo":{"externalids":{"MAG":"3016299367","ACL":null,"DOI":"10.1364\/ao.388483","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using a dense motion vector field as the main information the authors develop a region segmentation algorithm in which each region is matched to a four-parameter motion model. Based on Markov random fields the segmentation model detects moving parts of the human body with different apparent displacement such as the hands. The motion vector field has been estimated by a Baaziz pel-recursive method and considered together with others sources of information such as intensity contours, intensity values and non-compensated pixels as inputs of the Markov random field model. The maximum a posteriori criterion (MAP) is used for the optimization of the solution, and performed with a deterministic method: iterated conditional modes (ICM). Results on segmenting and classifying real sequences are shown and, based on a roughly defined directional dictionary, one application is pursuing the use of the segmented regions as commands for a virtual robot. The classification is based on the correlation coefficient (between the trained sequences and others) of wavelet coefficients, of the projected sum of the intensity of the segmentation field (in its binary version).","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":14770921,"openaccessinfo":{"externalids":{"MAG":"2114155311","ACL":null,"DOI":"10.1109\/VSMM.1997.622347","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo construct recombinant lentiviral vectors of porcine bone morphogenetic protein 2 (BMP-2) gene and to detect BMP-2 gene activity and bone marrow mesenchymal stem cells (BMSCs) osteogenetic differentiation so as to lay a foundation of the further study of osteochondral tissue engineering.\n\n\nMETHODS\nBMSCs were isolated from bone marrow of 2-month-old Bama miniature porcines (weighing, 15 kg), and the 2nd generation of BMSCs were harvested for experiments. The porcine BMP-2 gene lentiviral vector was constructed by recombinant DNA technology and was used to transfect BMSCs at multiplicity of infection (MOI) of 10, 25, 50, 100, and 200, then the optimal value of MOI was determined by fluorescent microscope and inverted phase contrast microscope. BMSCs transfected by BMP-2 recombinant lentiviral vectors served as experimental group (BMP-2 vector group); BMSCs transfected by empty vector (empty vector group), and non-transfected BMSCs (non-transfection group) were used as control groups. RT-PCR, immunohistochemistry staining, and Western blot were performed to detect the expressions of BMP-2 mRNA and protein. Then the BMSCs osteogenesis was detected by alkaline phosphatase (ALP) staining, ALP activities, and Alizarin red staining.\n\n\nRESULTS\nThe recombinant lentiviral vectors of porcine BMP-2 gene was successfully constructed and identified by RT-PCR and gene sequencing, and BMSCs were successfully transfected by BMP-2 recombinant lentiviral vectors. Green fluorescent protein could be seen in the transfected BMSCs, especially at MOI of 100 with best expression. The immunohistochemistry staining and Western blot showed that BMSCs transfected by BMP-2 recombinant lentiviral vectors could express BMP-2 protein continuously and stably at a high level. After cultivation of 2 weeks, the expression of ALP and the form of calcium nodules were observed.\n\n\nCONCLUSION\nThe porcine BMP-2 gene lentiviral vector is successfully constructed and transfected into the BMSCs, which can express BMP-2 gene and protein continuously and stably at a high level and induce BMSCs differentiation into osteoblasts.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":41314362,"openaccessinfo":{"externalids":{"MAG":"2386244174","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Claus process is one of the promising technologies for acid gas processing and sulfur recovery. Hydrogen sulfide primarily exists as a byproduct in the gas processing unit. It must be removed from natural gas. The Environmental Protection Agency (EPA) notices that increasing SO2 and CO2 in the air harms the environment. Sulfur generally has an elemental content of 0.1\u20136 wt % in crude oil, but the value could be higher than 14% for some crude oils and asphalts. It produces SO2 and CO2 gases, which damage the environment and atmosphere of the earth, called primary pollutants. When SO2 gas is reacted with water in the atmosphere, it causes sulphur and nitric acid, called a secondary pollutant. The world countries started desulphurization in 1962 to reduce the amount of sulfur in petroleum products. In this research, the Claus process was modeled in Aspen Plus software (AspenTech, Bedford, MA, USA) and industrial data validated it. The Peng\u2013Robinson method is used for the simulation of hydrocarbon components. The influence of oxygen gas concentration, furnace temperature, the temperature of the first catalytic reactor, and temperature of the second catalytic reactor on the Claus process were studied. The first objective of the research is process modeling and simulation of a chemical process. The second objective is optimizing the process. The optimization tool in the Aspen Plus is used to obtain the best operating parameters. The optimization results show that sulfur recovery increased to 18%. Parametric analysis is studied regarding operating parameters and design parameters for increased production of sulfur. Due to pinch analysis on the Claus process, the operating cost of the heat exchangers is reduced to 40%. The third objective is the cost analysis of the process. Before optimization, it is shown that the production of sulfur recovery increased. In addition, the recovery of sulfur from hydrogen sulfide gas also increased. After optimizing the process, it is shown that the cost of heating and cooling utilities is reduced. In addition, the size of equipment is reduced. The optimization causes 2.5% of the profit on cost analysis.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245545709,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/math10010088","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2227-7390\/10\/1\/88\/pdf?version=1640607028","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The chlorination of norbornene and cyclooctadienes with sulfuryl chloride and phosphorus(V) chloride has been investigated mainly in carbon tetrachloride under various conditions. From the studies of the product distributions and the effect of radical scavengers, the following facts have been revealed for the first time in olefin chlorination: chlorination with sulfuryl chloride proceeds through an ionic pathway at room temperature or in the presence of silica gel and that with phosphorus(V) chloride through a radical pathway at elevated temperature, and an ionic chlorination with phosphorus(V) chloride in nonpolar solvents does not seem to involve C\u2013P bond formation through the reaction.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":95093239,"openaccessinfo":{"externalids":{"MAG":"2025512259","ACL":null,"DOI":"10.1246\/BCSJ.51.3568","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The pervasive ambiguity of language allows sentences that differ in just one lexical item to have rather different inference patterns. This would be no problem if the different lexical items fell into clearly definable and easy to represent classes. But this is not the case. To draw the correct inferences we need to look how the referents of the lexical items in the sentence (or broader context) interact in the described situation. Given that the knowledge our systems have of the represented situation will typically be incomplete, the classifications we come up with can only be probabilistic. We illustrate this problem with an investigation of various inference patterns associated with predications of the form 'Verb from X to Y', especially 'go from X to Y'. We characterize the various readings and make an initial proposal about how to create the lexical classes that will allow us to draw the correct inferences in the different cases.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":14797130,"openaccessinfo":{"externalids":{"MAG":"2252033034","ACL":"W10-0914","DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor kidney for rejection, and contributes to the long-term risk of graft loss. In the last decade, epidemiological studies have linked even mild episodes of AKI to chronic kidney disease (CKD) progression, and innate immunity seems to play a crucial role. The ischemic insult triggers an acute inflammatory reaction that is elicited by Pattern Recognition Receptors (PRRs), expressed on both infiltrating immune cells as well as tubular epithelial cells (TECs). Among the PRRs, Toll-like receptors (TLRs), their synergistic receptors, Nod-like receptors (NLRs), and the inflammasomes, play a pivotal role in shaping inflammation and TEC repair, in response to renal IRI. These receptors represent promising targets to modulate the extent of inflammation, but also function as gatekeepers of tissue repair, protecting against AKI-to-CKD progression. Despite the important considerations on timely use of therapeutics, in the context of IRI, treatment options are limited by a lack of understanding of the intra- and intercellular mechanisms associated with the activation of innate immune receptors and their impact on adaptive tubular repair. Accumulating evidence suggests that TEC-associated innate immunity shapes the tubular response to stress through the regulation of immunometabolism. Engagement of innate immune receptors provides TECs with the metabolic flexibility necessary for their plasticity during injury and repair. This could significantly affect pathogenic processes within TECs, such as cell death, mitochondrial damage, senescence, and pro-fibrotic cytokine secretion, well-known to exacerbate inflammation and fibrosis. This article provides an overview of the past 5 years of research on the role of innate immunity in experimental and human IRI, with a focus on the cascade of events activated by hypoxic damage in TECs: from programmed cell death (PCD) and mitochondrial dysfunction-mediated metabolic rewiring of TECs to maladaptive repair and progression to fibrosis. Finally, we will discuss the important crosstalk between metabolism and innate immunity observed in TECs and their therapeutic potential in both experimental and clinical research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220365418,"openaccessinfo":{"externalids":{"MAG":"3038692776","ACL":null,"DOI":"10.3389\/fimmu.2020.01346","PubMedCentral":"7358591","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.01346\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Recent investigations of the microbial communities in an oil reservoir using culture-independent molecular techniques has indicated that this environment contains many uncultured assemblages, and that the cultured bacteria may represent very minor components of the true microbial diversity. In this study, 16S rDNA based PCR amplification and denaturing gradient gel electrophoresis (PCR-DGGE) was used to monitor the microbial diversity in an injection well (12#9-11) and two related production wells (12#9-9S, 13#11-8) in the KELAMAYI oilfield (Xin Jiang Autonomous Region) . The DGGE gel profiles showed significant difference between the microbial community structure of injection and production wells. The bacterial species richness in the injection well was higher than those of the production ones. Unweighted Pair Group Method Clustering (UPGMC) showed the similarity between the injection well and two production wells was 30% and 20% respectively, whereas the similarity between the two production wells was 54%. In addition, the dominant bands in the DGGE gel were excised and analyzed by nucleotide sequence analysis. This analysis of 10 excised bands showed that the dominant microorganisms in all samples had high sequence identity with rRNA genes from uncultured bacteria in the GenBank database (NCBI). Nine sequences of excised band were affiliated with alpha, gamma, delta, epsiv-Proteobacteria, and one was related to Bacteroides. Two bands exhibited 100% identity to sequences of Pseudomonas stutzeri and Aminobacter sp. cox, respectively. Three bands showed relatively low identity (92% to 93%) to cultured bacteria in the GenBank database, indicating possible new taxa. This work analyzed the composition of the microbial community in KELAMAYI oilfield, which provides important data which may facilitate the isolation of new bacteria from this special underground environment. It also provides useful information for understanding the mechanism of MEOR and applying MEOR in practical oil production in KELAMAYI oilfield.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13093518,"openaccessinfo":{"externalids":{"MAG":"2151662632","ACL":null,"DOI":"10.1109\/ICBBE.2009.5162946","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study solar radiation data obtained from Eskisehir region is mathematically modeled using a two dimentional (2D) approach. The approach and model is novel in the literature of solar radiation modeling. The analysis is based on mathematical behavior of hourly and daily behavioral cross-sections of the 2D data. It is observed that the deviation of the hourly data within a day exhibits a Gaussian shape, and the deviation of daily data in the year has a sinusoidal behavior. The hourly behaviour of daily data is tested by single and double Gaussian source models, whereas the daily behavior of yearly data is only modeled using sinusoidal function. By this way two different equations corresponding two different surfaces are obtained. It is concluded that single-source Gaussian surface represents the data more accurate than two dimentional Gasussian surface. Consequently, a very simple but an accurate 2D model is obtained for solar radiation data.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":22166811,"openaccessinfo":{"externalids":{"MAG":"2138962693","ACL":null,"DOI":"10.1109\/SIU.2008.4632560","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives Increased cardiac troponin I (TI) has been suggested to be a sensitive indicator of intraoperative myocardial injury. We investigated the association of transfusion on TI levels post-surgery and outcomes in patients undergoing elective cardiac surgeries. Methods We conducted a retrospective review of 542 patients. Patients were divided into two groups based on TI levels at 24 hours (TI24) (> 6.5 \u00b5g\/L vs. \u2264 6.5 \u00b5g\/L). The impact of transfusion on TI levels was estimated using logistic regression and adjusted for using a multivariable model that included aortic cross-clamp time and preoperative ejection fraction. The effect of TI on the clinical outcomes was examined. Results Red blood cell (RBC) transfusion was found to be associated with high TI levels (odds ratio (OR) = 2.33, p = 0.007, 95% confidence interval (CI): 1.30\u20134.30). A trend was observed when aortic cross-clamp time and preoperative ejection fraction were adjusted for (OR = 2.06, p = 0.080, 95% CI: 0.90\u20134.70). An association was found between aortic cross-clamp time and high TI levels in the multivariable model (OR = 1.01, p = 0.028, 95% CI: 1.00\u20131.02). Elevated TI levels was associated with higher mortality (OR = 4.15, p = 0.017, 95% CI: 1.29\u201313.08), renal failure (OR = 2.99, p = 0.004, 95% CI: 1.41\u20136.32), and increased length of stay in-hospital (OR = 4.50, p = 0.020, 95% CI: 0.69\u20138.30). Conclusions RBC transfusion is associated with increased TI24 post-cardiac surgery and worse outcomes, albeit a confounding effect cannot be excluded. Larger studies are required to confirm these findings.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58947980,"openaccessinfo":{"externalids":{"MAG":"2910545754","ACL":null,"DOI":"10.5001\/omj.2019.03","PubMedCentral":"6330194","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.5001\/omj.2019.03","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Maternal blood leptin levels are positively associated with adiposity. Recent studies suggest that leptin is also abundantly produced by the placenta and may function as a regulator of foetal growth. Our goal was to examine mid\u2010pregnancy levels of leptin in maternal blood in relation to birthweight for gestational age (BW\/GA) and timing of delivery after accounting for maternal prepregnancy body mass index (prepreg\u2010BMI) and pregnancy complications.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204990732,"openaccessinfo":{"externalids":{"MAG":"2071160543","ACL":null,"DOI":"10.1111\/cen.12029","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc4004085?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The results of verification strength test in site of the switch type R65 mark 1\/11 of the design Dn 355 are presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":258934768,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15802\/stp2010\/8886","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/stp.diit.edu.ua\/article\/download\/8886\/7698","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Thirty adult patients who had thoracoplasties for pulmoary tuberculosis were carefully studied to define the syndrome of thoracoplastic scoliosis. After thoracoplasty, a mild-to-moderate cervicothoracic scoliosis occurs. In most cases the convexity is toward the side of resection and the rotation is toward the concavity. The major curve is limited to the segments of the thoracic spine adjacent to the resected ribs and the apex of the curve is centrally placed in the region of the resected ribs. The degree of curvature is directly proportional to the number of ribs resected, and those patients who have had transversectomies have greater degrees of curvature. Most of the angular deformity develops within one week after surgery and there is virtually no progression after one year in adult patients.\n\nIt is clear from this study and the experimental studies of others that the rib cage is an important support of the vertebral column. Several theories are presented regarding the role of the rib cage.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":26802346,"openaccessinfo":{"externalids":{"MAG":"10646559","ACL":null,"DOI":"10.2106\/00004623-196648020-00014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT: In recent years, several researchers have been studying obesity in national horse breeds; however, no studies demonstrating the dynamic of body and regional fat accumulation (adiposity) Mangalarga Marchador horses subjected to hypercaloric diets have been found. This study aimed to characterize the deposition of body and regional fat in horses with diet-induced weight gain. A total of nine Mangalarga Marchador adult horses with initial body condition score (BCS) of 2.9 \u00b11\/9 (mean \u00b1SD) were subjected to a hypercaloric, grain-rich diet for five months. Body weight and the following morphometric regional adiposity variables were analyzed: BCS, cresty neck scores (CNS), neck circumferences (NC) at 25, 50 and 75% of its length, and accumulation of subcutaneous adipose tissue at the base of the tail using ultrasonography (BTU). These data were collected at baseline and fortnightly after beginning the diet-induced weight gain until the end of the experiment. The effect of time on the variables was verified by analysis of variance (ANOVA) in randomized blocks or the Friedman's test, and the means were compared by the Tukey's test (p\u22640.05). Exposure to hypercaloric diet promoted a mean weight gain of 27.45% (p<0.001). Significant values were observed for NC at 25 and 75% during the first 45 days of the experiment, and for NC at 50% during the first 30 days. BTU presented significant changes after 60 days, with an increase of 268% compared with the baseline value. These findings demonstrate the weight gain and the dynamic and magnitude of regional adiposity in Mangalarga Marchador horses subjected to hypercaloric diet.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":226104875,"openaccessinfo":{"externalids":{"MAG":"3032945081","ACL":null,"DOI":"10.1590\/1678-5150-pvb-6178","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"http:\/\/www.scielo.br\/pdf\/pvb\/v40n3\/1678-5150-pvb-40-03-170.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The value of peat bogs as open habitats and stores of carbon may be lost if they are planted with trees. The number of bogs being restored is increasing but still modest in scale relative to the area of afforested peatland. Research is currently being carried out to determine the feasibility and methodology for restoring afforested bogs. Two experiments were set up to compare a range of methods for managing trees and drainage. In the blanket bog experiment, treatments that involved both felling trees and damming plough furrows were more successful than others in terms of raising the water table. Bog vegetation recovered rapidly in the felled treatments, particularly those with furrows dammed. In the lowland raised bog experiment, the water table rose dramatically in all treatments. Only during a prolonged dry summer was there a difference between treatments, the water table falling deeper in the whole-tree removal than in the fellto-waste treatment, with conventional harvesting intermediate. Bog vegetation recovered best in the whole-tree removal treatments and least well in the fell-to-waste treatments. Felling is necessary for restoring afforested bogs, but removing lop and top is not. Damming plough furrows can help to restore blanket bog but damming main drains may suffice on lowland raised bogs. Damming furrows is ineffective if the peat is severely cracked. Tree seedlings often colonise bogs undergoing restoration \u2013 removing brash mats after harvesting and periodic maintenance should reduce this problem. Research Note","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":131511624,"openaccessinfo":{"externalids":{"MAG":"2206304068","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Film bulk acoustic resonators (FBAR) are promising candidates to replace surface acoustic wave devices as filters or delay lines, but also offer exciting opportunities as biological or gas sensors. In this work, solidly mounted FBARs were manufactured by substituting commonly used pure aluminium nitride (AlN) by scandium doped aluminium nitride (ScAlN) thin films as the piezoelectric layer. The ScAlN-based resonators feature a significant improvement of the electromechanical coupling factor from ~3% to ~12% compared to the pure AlN, while the decreased stiffness of ScAlN results in a decrease of the quality factor from ~300 to ~100 due to increased damping losses in the piezoelectric material.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":141156842,"openaccessinfo":{"externalids":{"MAG":"2924842974","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aetiology of equine grass sickness (EGS) is still unknown. There is increasing evidence that toxicoinfection with Clostridium botulinum type C is involved. Epidemiological evidence shows that resistance to EGS can occur in older horses and those that have been on a particular pasture for longer or have been in prior contact with the disease. This resistance may be in the form of an immune response to the aetiological agent. Levels of systemic antibodies to the surface antigens of C. botulinum type C (using the closely related and safe C. novyi type A as a phenotypic marker) and to the botulinum type C neurotoxin (BoNT\/C) were investigated in horses with and without EGS. Horses with grass sickness were found to have significantly lower levels of systemic IgG to both surface antigens and BoNT\/C. Horses with low levels of systemic immunity to these antigens may be more susceptible to developing EGS. There were no significant differences in antibody levels between the different categories of EGS, suggesting systemic immunity to C. botulinum type C does not play a significant role in influencing the severity of the disease. However, horses that had been in contact with EGS or that were grazing land where it had occurred frequently in the past had significantly higher antibody levels to these antigens. These horses may have been exposed to subclinical doses of C. botulinum type C and BoNT\/C, resulting in the production of a protective immune response against the putative aetiological agent. This finding is of potential significance for the prospect of prevention of EGS by vaccination against C. botulinum type C.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25674910,"openaccessinfo":{"externalids":{"MAG":"1975185368","ACL":null,"DOI":"10.2746\/042516401776563418","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we endogenously compute worst-case weather events in a transmission system expansion planning problem using the robust optimization approach. Mathematically, we formulate a three-level mixed-integer optimization problem, which we convert to a bi-level problem via the strong duality concept. We solve the problem using a constraint-and-column generation algorithm. We use cardinality-constrained uncertainty sets to model the effects of extreme weather realizations on supply from renewable generators.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":253047406,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/EEM54602.2022.9921145","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Promontories and embayments along the late Precambrian-early Paleozoic Appalachian-Ouachita continental margin of south-eastern North America are framed by a northeast-striking rift system offset by northwest-striking transform faults. Inboard from the continental margin, basement fault systems have two sets of orientation; one is northeast parallel with rift segments, and the other is northwest parallel with transform faults. Late Precambrian clastic and volcanic syn-rift rocks overlie Precambrian basement rocks along the Appalachian Blue Ridge. Lower Cambrian sandstone at the base of a transgressive passive-margin succession over-steps the rift-fill successions and basement rocks, defining the time of transition from an active rift to a passive margin along the Blue Ridge. Locally thick Early Late Cambrian and older sedimentary rocks fill downthrown blocks of the intracratonic Mississippi Valley-Rough Creek-Rome graben system and Birmingham basement fault system. These basement fault systems, which indicate north-west-southeast extension like the Blue Ridge rift, are overstepped by Upper Cambrian strata. The northwest-striking Southern Oklahoma fault system is interpreted to be a transform fault that propagated into the continent from the Ouachita rift. Early and Middle Cambrian rift-related igneous rocks along the fault system and adjacent Precambrian basement are overstepped by Upper Cambrian sandstone. The differences in age of rift-related rocks suggest a spreading-center shift at the beginning of the Cambrian Period from the Blue Ridge rift to the Ouachita rift southwest of the Alabama-Oklahoma transform fault. From Early to Early Late Cambrian, a small component of extension propagates north-eastward to form the intracratonic fault systems northeast of the transform fault, but most of the extension of the Ouachita rift was transformed along the Alabama-Oklahoma transform fault to the Mid-Iapetus Ridge outboard from the Blue Ridge passive margin.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":140645354,"openaccessinfo":{"externalids":{"MAG":"2096158709","ACL":null,"DOI":"10.1130\/0016-7606(1991)103<0415:TAORMO>2.3.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract We propose a new, more actionable view of neural network interpretability and data analysis by leveraging the remarkable matching effectiveness of representations derived from deep networks, guided by an approach for class-conditional feature detection. The decomposition of the filter-n-gram interactions of a convolutional neural network (CNN) and a linear layer over a pre-trained deep network yields a strong binary sequence labeler, with flexibility in producing predictions at\u2014and defining loss functions for\u2014varying label granularities, from the fully supervised sequence labeling setting to the challenging zero-shot sequence labeling setting, in which we seek token-level predictions but only have document-level labels for training. From this sequence-labeling layer we derive dense representations of the input that can then be matched to instances from training, or a support set with known labels. Such introspection with inference-time decision rules provides a means, in some settings, of making local updates to the model by altering the labels or instances in the support set without re-training the full model. Finally, we construct a particular K-nearest neighbors (K-NN) model from matched exemplar representations that approximates the original model's predictions and is at least as effective a predictor with respect to the ground-truth labels. This additionally yields interpretable heuristics at the token level for determining when predictions are less likely to be reliable, and for screening input dissimilar to the support set. In effect, we show that we can transform the deep network into a simple weighting over exemplars and associated labels, yielding an introspectable\u2014and modestly updatable\u2014version of the original model.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":202235043,"openaccessinfo":{"externalids":{"MAG":"2971795534","ACL":"2021.cl-4.25","DOI":"10.1162\/coli_a_00416","PubMedCentral":null,"ArXiv":"1906.01154"},"license":"CCBYNCND","url":"https:\/\/direct.mit.edu\/coli\/article-pdf\/47\/4\/729\/1979432\/coli_a_00416.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Using a method of in vivo labeling of erythrocytes and subsequent whole-body scanning, we investigated the effect of nitroglycerin (NTG) on regional blood pooling in patients with chronic left heart failure (six men and two women). A group of eight patients with coronary heart disease who did not receive any NTG served as controls. These data were compared with the effects of NTG in ten male patients suffering from coronary artery disease. Up to 25 min after sublingual administration of 1.6 mg NTG we observed a significant decrease in radioactivity in the regions of heart, lung, and liver (maximal per hundred 6.0, 6.5, and 4.8 respectively) indicating the reduction in local blood volume. In the abdomen, the arms, and the legs we observed an increase in regional blood volume (maximum 9.7%, 8.3%, and 6.5% respectively). An overall significant change usually began approximately 5 min after NTG and lasted for about 20 min. In contrast to patients with left heart failure, patients with coronary artery disease did not show any significant difference in pulmonary and abdominal regions after NTG. The noninvasive method used allows an immediate determination of drug-induced regional blood volume pooling.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":21097389,"openaccessinfo":{"externalids":{"MAG":"2405216558","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The society as a whole, and many vertical sectors in particular, is becoming increasingly digitalized. Machine Type Communication (MTC), encompassing its massive and critical aspects, and ubiquitous wireless connectivity are among the main enablers of such digitization at large. The recently introduced 5G New Radio is natively designed to support both aspects of MTC to promote the digital transformation of the society. However, it is evident that some of the more demanding requirements cannot be fully supported by 5G networks. Alongside, further development of the society towards 2030 will give rise to new and more stringent requirements on wireless connectivity in general, and MTC in particular. Driven by the societal trends towards 2030, the next generation (6G) will be an agile and efficient convergent network serving a set of diverse service classes and a wide range of key performance indicators (KPI). This white paper explores the main drivers and requirements of an MTC-optimized 6G network, and discusses the following six key research questions: \n- Will the main KPIs of 5G continue to be the dominant KPIs in 6G; or will there emerge new key metrics? \n- How to deliver different E2E service mandates with different KPI requirements considering joint-optimization at the physical up to the application layer? \n- What are the key enablers towards designing ultra-low power receivers and highly efficient sleep modes? \n- How to tackle a disruptive rather than incremental joint design of a massively scalable waveform and medium access policy for global MTC connectivity? \n- How to support new service classes characterizing mission-critical and dependable MTC in 6G? \n- What are the potential enablers of long term, lightweight and flexible privacy and security schemes considering MTC device requirements?","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":216642118,"openaccessinfo":{"externalids":{"MAG":"3021735486","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2004.14146"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We show a pointwise estimate for the Fourier transform on the line involving the number of times the function changes monotonicity. The contrapositive of the theorem may be used to find a lower bound to the number of local maxima of a function. We also show two applications of the theorem. The first is the two weight problem for the Fourier transform, and the second is estimating the number of roots of the derivative of a function.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197502827,"openaccessinfo":{"externalids":{"MAG":"2950962490","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Current problems in the protection of economic rights in Eastern Europe (the impact of the oil industry on the environment and human health, discrimination in employment, including the abuse of the rights of migrant workers and women) determine the potential for economic development. This scientific article based on: qualitative and quantitative methodology; combination of comprehensive and systematic approaches; case method; analysis of statistical indicators. The aim of the research is to analyze the protection of economic rights in Eastern European countries and their negative impact on the lives of citizens. It has been found that in addition to unresolved issues of non-payment of salaries and discrimination against various social groups, these countries have new problems in the field of protection of intellectual property rights through the development of the digital economy. The legal system carefully and slowly integrates the practice of developed countries to provide guarantees for the most vulnerable (women, migrant workers). As a result, Eastern European countries are characterized by slow structural changes in the economy and an average level of GDP per capita. Discrimination, which is characterized by differences, is among the main problems. Discrimination does not ensure equal access for women to all spheres of public life. The revealed connection between gender equality and the economic well-being of the population proves the importance of protecting economic rights as a tool to ensure the formation of a socially oriented market economy. In Eastern European countries, there is no consistent concept of equality regardless of the social-economic characteristics of the citizen. Judicial practice remains quite cautious in sentencing and there are cases of return to formal equality.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":235567252,"openaccessinfo":{"externalids":{"MAG":"3159361872","ACL":null,"DOI":"10.37394\/23207.2021.18.76","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.37394\/23207.2021.18.76","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The huge impact that Darwinian Evolutionism has effected over Chinese intellectuals through Yan Fu's translation of Huxley's \"Evolution and Ethics\" into the Tianyanlun, is in fact based on Chinese traditional worldview on the one hand and the novel ideas it brings to the Chinese mind facing the challenge of transition. However, Yan Fu's translation is not as scientific as it should be when dealing with Huxley's discourse. Ma Junwu's translation of Darwin's \"On the Origin of Species\" attempts to be more scientific, in an effort to supply exact scientific terms and discourse in Chinese. However, at the end it is social Darwinism that has won the mind of the Chinese people. This paper analyses the ideas in Chinese past that leads to Chinese perception of Darwimism evolutionism and examines the ways it has been translated by Yan Fu and Ma Junwu.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53414348,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chemical Cartography, or mapping, of our Galaxy has the potential to fully transform our view of its structure and formation. In this work, we use chemical cartography to explore the metallicity distribution of OBAF-type disk stars from the LAMOST survey and a complementary sample of disk giant stars from Gaia DR3. We use these samples to constrain the radial and vertical metallicity gradients across the Galactic disk. We also explore whether there are detectable azimuthal variations in the metallicity distribution on top of the radial gradient. For the OBAF-type star sample from LAMOST, we find a radial metallicity gradient of \u0394[Fe\/H]\/\u0394R \u223c\u22120.078 \u00b1 0.001\u00a0dex\/kpc in the plane of the disk and a vertical metallicity gradient of \u0394[Fe\/H]\/\u0394Z \u223c\u22120.15 \u00b1 0.01\u00a0dex\/kpc in the solar neighborhood. The radial gradient becomes shallower with increasing vertical height while the vertical gradient becomes shallower with increasing Galactocentric radius, consistent with other studies. We also find detectable spatially-dependent azimuthal variations on top of the radial metallicity gradient at the level of \u223c0.10\u00a0dex. Interestingly, the azimuthal variations appear be close to the Galactic spiral arms in one dataset (Gaia DR3) but not the other (LAMOST). These results suggest that there is azimuthal structure in the Galactic metallicity distribution and that in some cases it is co-located with spiral arms.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":250426001,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/mnras\/stad1244","PubMedCentral":null,"ArXiv":"2207.04542"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/2207.04542","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The present understanding of the magnetic field lines reconnection, both the externally driven and spontaneous ones, is reviewed. The discussion of the theory is centered around the nonlinear limitation of the reconnection rate. Modification of the magnetic field structure in the region of plasma outflow by the plasma current near the neutral X-line limits the reconnection rate to the value lower than that given by Petschek. In collisionless plasma the ion trapping by the space charge near the X-line imposes slightly weaker limitation. The structure of the dissipation region in the case of nonvanishing (sheared) magnetic field is described for the tearing mode reconnection and the implications of this analysis for the externally driven reconnection of the strained magnetic field lines are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119750250,"openaccessinfo":{"externalids":{"MAG":"1980994494","ACL":null,"DOI":"10.1088\/0031-8949\/1994\/T52\/002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conflicts between humans and animals have been a challenge due to rapid urbanization. Most of the forest is cleared to build roads and highway. Thus, animals need to migrate or move for their survival. This paper aims to review wildlife roadkill data from PERHILITAN and arranged it under several groups of species. Here, quantitative analysis of the roadkill data is used to select one species as the primary subject (Malayan Tapir). It has been observed that Malayan Tapir has involved in 68 vehicle collisions with a total loss of RM6.8 million in 5 years. From these results, long-term mitigation measures have been addressed in this study.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":232555071,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction:\n Macrophage activation syndrome (MAS) is a life threatening disease that is increasingly recognized in children with inflammatory conditions including Kawasaki disease (KD). We describe the prevalence, clinical features and outcomes of patients with MAS secondary to KD.\n \n \n Methods:\n All patients diagnosed and treated for KD at The Hospital for Sick Children between 2001 and 2013 were included and reviewed for features of MAS. A diagnosis of MAS required 4 out of the following clinical findings: fever, hepatosplenomegaly, cytopenia in at least 2 cell lines, hyperferritinemia, hypofibrinogenemia and\/or hypertriglyceridemia, and presence of biopsy-proven hemophagocytosis.\n \n \n Results:\n Of 1,020 patients included in this study, 21 met MAS diagnostic criteria for an incidence of 2.1% (95% CI: 1.4-3.1%). All patients had fever, 9 (43%) hepatosplenomegaly, 10 (47%) hypofibrinogenemia and\/or hypertriglyceridemia, 19 (90%) hyperferritinemia, 19 (90%) cytopenia, and 7 (33%) biopsy-confirmed hemophagocytosis. MAS was associated with: older age at KD diagnosis (median 5.7 vs. 3.0 years, p=0.06), longer fever duration prior to diagnosis (median 10 vs. 6 days, p=0.01), and higher incidence of incomplete KD (57% vs. 32%, p=0.04) and confirmed infection during acute phase (48% vs. 19%, p=0.02). Treatment included multiple IVIGs for 12 patients (57%), methylprednisolone for 15 (71%), oral prednisone for 13 (62%) and cyclosporine for 2 (10%). Median total duration of fever was 13 days (vs. 7 days, p=0.001), duration of fever after first IVIG treatment was 4 days, and median duration of hospital stay was 6 days (vs. 3 days, p=0.01). 5 patients received pRBC transfusions, 3 required ICU care, 1 had severe CNS involvement, and 1 developed multisystem organ failure dying 28 days after admission. Mild transient coronary dilatation was seen in 3 patients\n \n \n Conclusions:\n The clinical presentation of KD and MAS are quite similar. Both entities are syndrome complexes defined by massive immune activation and share pro-inflammatory cytokine signatures. MAS is a rare but important complication with KD. Further research is needed to optimize diagnosis and management.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":81003289,"openaccessinfo":{"externalids":{"MAG":"2902374626","ACL":null,"DOI":"10.1161\/circ.131.suppl_2.o28","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In order to maintain the historical scaling of computational power in information processing beyond the 2020 technology node, switches that are based on state variables other than electron charge are currently being investigated. Examples of alternate state variables include the electron spin, pseudo-spin in graphene, and excitons. This paper discusses different communication mechanisms for on-chip local interconnects for post-CMOS devices. Models for delay and energy dissipation for novel interconnects are obtained, and a comparison is provided with their CMOS counterpart. It is shown that novel interconnects can potentially consume less energy per bit as compared to the CMOS interconnects. However, they pose significant delay penalty. The paper highlights some of the major implications of the novel interconnects on the post-CMOS circuits.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":39694540,"openaccessinfo":{"externalids":{"MAG":"2169479028","ACL":null,"DOI":"10.1109\/IITC.2010.5510448","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To study effects of drought stress on growth and photosynthetic characteristics of Eucalyptus grandis saplings,a pot experiment kept under continuous drought was performed. Growth and photosynthetic parameters of the saplings were monitored once every two days after irrigation,that is,on D_2,D_4,D_6,D_8,D_(10),D_(12),D_(14) and D_(16),while the sampling with normal irrigation as DO. Results show that( 1) during the first 6 days,although growth of the saplings in ground diameter and plant height declined,it did not differ much from that on D_0( P 0. 05); however,with the stress going on( D_8-D_(16)),the growth of the saplings in ground diameter and plant height dropped significantly.( 2) with the stress going on,the content of chlorophyll a( Chl a) in the saplings decreased significantly( P0. 05),whereas chlorophyll a \/ chlorophyll b ratio( Chl a \/ b) followed a rising-and-then-falling trend,and the content of Chlorophyll b and carotenoids on D2 did not change much from their respective ones on D_0( P0. 05),but were getting much lower from D_4 than those on D_0( P 0. 05);( 3) with the stress going on,net photosynthetic rate( Pn),transpiration rate( Tr),stomatal conductance( Gs) of the saplings decreased significantly( P0. 05) while intercellular CO_2concentration( Ci) decreased first and then increased;( 4) with the stress going on,apparent quantum yield( YAQ),Ru BP apparent carboxylation rate( Ec),light saturation point( Lsp) and CO_2 saturation point( Csp) of the saplings were all on declining trends,while light compensation point( Lcp),CO_2 compensation point( Ccp) on rising ones and maximum net photo-syntheticrate( Pmax) was on a declining one. In summary,with the drought stress aggravating,the content of photosynthetic pigments in the saplings decreased; stomata closed partly; photosynthetic organs were damaged to some extent,thus greatly reducing the saplings' ability to use light and CO_2 and their photosynthetic rate,and consequently suppressing growth of the E. grandis saplings.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":88051195,"openaccessinfo":{"externalids":{"MAG":"2386977681","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The main objective of this work, was the isolation, chemical and nutritional (in vitro) characterization of the two main protein fractions of bovine blood serum. Immediatly after hygienic collection at the slaughter house the blood was coagulated and the cellular fraction separated by centrifugation under appropriate conditions. The globulin (GB) fraction was precipitated from blood serum by 50% saturation with ammonium sulfate. The supernalant was separated by centrifugation and the (NH4)2SO4 saturation elevated to 80%. Under this condition BSA precipitated. Precipitation (recovery) of proteins amounted to 98% of total serum protein, in the two fractions. Both GB and BSA were characterized as to proximate percent composition, mineral, amino acid profiles, essential amino acid score (EAE), protein digestibility, and protein digestibility corrected amino acid scoring (PDCAAS). Protein concentration in both fractions was around 85%. BSA presented high concentrations of lysine, histidine and sulfur amino acids, particulary cistine. The EAE for BSA was 70%, tryptophan being the most limiting amino acid, and for GB the EAE score was 87.8% with isoleucine as the most limiting amino acid. PAGE-SDS and densitometry permitted the fractions characterization as the number of protein bands molecular weight and relative proportions among the various proteins.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85266812,"openaccessinfo":{"externalids":{"MAG":"2080661466","ACL":null,"DOI":"10.1590\/S0101-20612005000200025","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The basis of the quasiclassical operator (QO) method is described. Application of the method for series of problems are discussed. These are processes in the superposition of plane wave and constant field, radiation in linear colliders, radiation in inhomogeneous fields, the new approach to the pair creation by a photon in a magnetic field, the theory of radiation in oriented crystals, radiation spectra taking into account the energy loss.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121383105,"openaccessinfo":{"externalids":{"MAG":"2027023933","ACL":null,"DOI":"10.1088\/1742-6596\/198\/1\/012003","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/198\/1\/012003\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Introduction: Anti-inflammatory, topical therapy of severe keratitis in dry eye disease (DED) and ocular graft-versus-host disease (oGvHD) includes steroids, cyclosporine (Cs), and others. In Germany, a commercial product containing 0.1% Cs in a cationic formulation is available since 2015. Objective: The aim of this study was to present real-life data using cationic 0.1% Cs in oGvHD patients. Methods: This was a retrospective study of 26 oGvHD and 41 DED patients with corneal staining of at least Oxford grade III. Parameters analyzed were Ocular Surface Disease Index, corneal staining, intraocular pressure, tear film break-up time, Schirmer, and visual acuity. In addition, it was evaluated how different Cs formulations were tolerated. Results: Corneal staining improved significantly in 1 eye in DED but not in oGvHD. In DED, cationic 0.1% Cs was not tolerated by 32% of the patients, in contrast to 0.05% Cs in castor oil not tolerated by 47% and liposomal 0.05% Cs by 63%. In oGvHD patients, cationic 0.1% Cs was not tolerated by 62%, 0.05% Cs in castor oil by 33%, and liposomal 0.05% Cs by 39% of the patients. Conclusions: This study demonstrates differences between the tolerance of different Cs formulations depending on the underlying cause of severe keratitis. Cationic 0.1% Cs is considerably less tolerated in oGvHD, and its use should be considered with care.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219171673,"openaccessinfo":{"externalids":{"MAG":"3029831217","ACL":null,"DOI":"10.1159\/000509034","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.karger.com\/Article\/Pdf\/509034","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study is to investigate the usefulness of statistical decomposition measures in the prediction of industrial bond rating changes. Further, the predictive ability of decomposition measures is compared with multiple discriminant analysis on the same sample. The problem of this study is twofold. It stems in general from the statistical problems associated with current techniques employed in the study of bond ratings and in particular from the lack of attention to the study of bond rating changes. Two main hypotheses are tested in this study. The first is that bond rating changes can be predicted through the use of financial statement data. The second is that decomposition analysis can achieve the same performance as multiple discriminant analysis in duplicating and predicting industrial bond rating changes. To explain and predict industrial bond rating changes, statistical decomposition measures were computed for each company in the sample. Based on these decomposition measures, the two types of analyses performed were (a) a univariate analysis where each decomposition measure was compared with an industry average decomposition measure, and (b) a multivariate analysis where decomposition measures were used as independent variables in a probability linear model. In addition to statistical decomposition analysis, multiple discriminant analysis was used in duplicating and predicting bond rating changes. Finally, a comparison was made between the predictive abilities of decomposition analysis and discriminant analysis.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":153145155,"openaccessinfo":{"externalids":{"MAG":"608882083","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the ciliate Euplotes raikovi, a 631-amino acid Er-MAPK1 protein kinase was found to localize in nucleoli of the transcriptionally active nucleus (macronucleus) and act as a key component of an autocrine, cell-growth promoting self-signaling mechanism. While its 283-amino acid N-terminal domain includes all the structural specificities of the mitogen-activated protein kinases required for a catalytic function, the 348-amino acid C-terminal domain is structurally unique with undetermined functions. By expressing the two Er-MAPK1 domains tagged with the green fluorescent protein in mammalian fibroblasts, the yeast Schizosaccharomyces pombe and the ciliate Tetrahymena thermophila, evidence was obtained that the C-terminal domain contains all the sequence information responsible for the Er-MAPK1 subcellular localization. However, in fibroblasts and S. pombe this information determined a nucleolar localization of the GFP-tagged C-terminal domain, and a ciliary localization in T. thermophila. In the light of these findings, the Er-MAPK1 localization in E. raikovi was re-examined via immunoreactions and shown to be ciliary besides that nuclear, as is the case for the mammalian intestinal cell kinase with which the Er-MAPK1 N-terminal domain shares a strong sequence identity and a catalytic function.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204737685,"openaccessinfo":{"externalids":{"MAG":"2981294198","ACL":null,"DOI":"10.3389\/fcell.2019.00244","PubMedCentral":"6811501","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2019.00244\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper presents the integration of three-axis accelerometers sensors and the ZigBee networks for assess the gait cycle, in order to monitor a gait at any time and at any- where, it through ambulatory a wearable gait monitoring system for application in a hospital network, or continuous monitoring in a patient's diary life. The biomechanical analysis proposal of gait was conducted in two stages: (1) Integration of network nodes and the accelerometers sensors, and the private profile design for multiple ZigBee devices over the wireless network and (2) Assembly of the experimental evaluation of normal gait with the ZigBee accelerometers devices over a normal human lower limb. Finally, this work presents the experimental results based on measurements of three-axis accelerations in the ankle, knee and hip with a biomechanical analysis of the stance and swing phase in the normal gait.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":114860768,"openaccessinfo":{"externalids":{"MAG":"2560552731","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lymph node metastasis indicates a poor prognosis in colorectal cancer. To better understand the underlying mechanisms of lymph node metastasis, we analyzed transcriptome characteristics of the pre-metastatic lymph node, a putative microenvironment favorable for the seeding and proliferation of cancer cells. Thus, we tried to compare and elucidate the transcriptional and immune characteristics of sentinel lymph nodes (SNs) with matched non-sentinel lymph nodes (NSNs) in colorectal cancer patients. In this study, a total of 38 pairs of SNs and NSNs were collected, in which 26 pairs of non-metastatic lymph nodes were subjected to RNA-seq and bioinformatics analysis for the gene expression profiles. There were 16 differentially expressed genes between SNs and NSNs being identified, including 9 upregulated and 7 downregulated genes in SN. Gene Ontology (GO) classification analysis revealed that the differentially expressed genes were mainly involved in leukocyte differentiation, chemokine secretion, and immune system regulation. In the meantime, gene set enrichment analysis (GSEA) showed that immune-related signaling pathways, such as transforming growth factor beta (TGF-\u03b2) signaling and tumor necrosis factor alpha (TNF-\u03b1)\/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) signaling, were enriched in NSN, while cell proliferation\u2013related signaling pathways were enriched in SN, including MYC signaling and G2M checkpoint signaling. We further identified SIGLEC15 as a top upregulated gene in SN. However, RNAscope assay showed that SIGLEC15 was not largely co-expressed with M2 macrophage marker CD163. We then selected eight pairs of lymph nodes for further cytological studies. Flow cytometry analysis revealed that Siglec-15 was expressed on all myeloid cell subsets. The relative expression of SEGLEC15 (SN\/NSN) was correlated with the microsatellite instability (MSI) status in colorectal cancer patients. Further studies found that small interfering ribonucleic acid (siRNA)-mediated silencing of SLGLEC15 can enhance the anti-tumor function of T cells, as indicated by cytokine release analysis. In conclusion, we presented here a first report on the gene expression profiling of the pre-metastatic lymph node in colorectal cancer. The findings in this study suggest that SIGLEC15 plays an important role in SN immunosuppression. SEGLEC15 silencing could be a therapeutic strategy for restoring T cell function in tumor SNs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238639493,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fcell.2021.691937","PubMedCentral":"8548766","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.691937\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to find out factors influencing dropout among boys in public primary schools in Dagoretti District, Nairobi, Kenya. The objectives of the study were; to determine the influence of pupil's peer pressure, to establish the effect of family stability, to determine the influence of school leadership and to establish the influence of overcrowded classrooms, on the dropout rates among boys in public primary schools. The study might be significant to Ministry of Education planners in developing sustainable interventions to keep the boy child in school, based on the various factors that affect their dropout rates. The study was conducted in public primary schools in Dagoretti District using descriptive survey. The study sample comprised of 24 head teachers, 72 teachers, 126 boys who had dropped out of school and 148 boys in class eight, the year 2012. Reliability of the instrument was determined by piloting instruments in the neighbouring Langata district and validity was enhanced by requesting experts in the area of research methods to examine the instruments for content validity. Qualitative and quantitative data was analysed and presented in tables of frequencies, percentages and figures. Key findings revealed that; broken families, poverty in households and poor supervision by parents, level of education of parents, loss of parent and households having low value for education negatively affected retention of boys in school. Attachment to negative peer xm groups, involvement in income generating activities, low self-motivation and lack of interest in education were identified by teachers as being the major factors influencing dropout. The boys who had dropped out of school identified involvement in bad company, separation of father and mother and income generating activities as the major factors that influence dropout. Similarly, the boys still in school singled out drug abuse, bad company, income generating activities and health related problems as the major contributors to boys' dropouts. From the study, it is recommended that the government should introduce and enforce parental laws to ensure children do not fall victim to abuse, public primary schools should enhance co-curricular activities so the pupils can develop their talents. The \\ \u2022 government should conduct awareness campaigns to ensure parents and pupils fully appreciate the importance of basic education.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":156284821,"openaccessinfo":{"externalids":{"MAG":"2410512108","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In a double blind prospective study of side effects to cervical myelography 38 patients were evaluated with neurologic examination, electroencephalography (EEG), brainstem evoked response (BER), somatosensory evoked responses (SSER), and continuous reaction times prior to and at 6 h and 24 h after myelography with either metrizamide or iohexol. A difference in the incidence of side effects (for example headache, dizziness, nausea, and neck pain) to the two different contrast media indicated that the inconveniences related to myelography were not only due to the spinal puncture. A contrast medium effect on the central nervous system varying from one agent to another was present. A high frequency of EEG deteriorations among patients with adverse clinical reactions and on only discrete affection upon BER indicated the reaction to be located to the cerebral cortex. Weakened tendon reflexes and reduced strength in the upper extremities were probably caused by blockade in the motor roots as SSER were normal indicating no affection of the sensory pathways. This hypothesis is in agreement with the fact that the patients were in the prone position in the first phase of the investigation causing the highest concentration of contrast medium around the motor roots and the anterior part of the spinal cord. Difference in metabolic effect may explain differences in side effects of metrizamide and iohexol.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7625935,"openaccessinfo":{"externalids":{"MAG":"1990988114","ACL":null,"DOI":"10.1177\/028418519103200516","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Importance Neonatal abstinence syndrome, which occurs as a result of in utero opioid exposure, affects between 6.0 and 20 newborns per 1000 live US births. There is substantial variability in how neonatal abstinence syndrome is diagnosed and managed. Objective To summarize key studies examining the diagnosis and management (both pharmacologic and nonpharmacologic) of neonatal abstinence syndrome published during the past 10 years. Evidence Review PubMed, Web of Science, and CINAHL were searched for articles published between July 1, 2007, and December 31, 2017. Abstracts were screened and included in the review if they pertained to neonatal abstinence syndrome diagnosis or management and were judged by the authors to be clinical trials, cohort studies, or case series. Findings A total of 53 articles were included in the review, including 9 randomized clinical trials, 35 cohort studies, 1 cross-sectional study, and 8 case series\u2014representing a total of 11 905 unique opioid-exposed mother-infant dyads. Thirteen studies were identified that evaluated established or novel neonatal abstinence syndrome assessment methods, such as brief neonatal abstinence syndrome assessment scales or novel objective physiologic measures to predict withdrawal. None of the new techniques that measure infant physiologic parameters are routinely used in clinical practice. The most substantial number of studies of neonatal abstinence syndrome management pertain to nonpharmacologic care\u2014specifically, interventions that promote breastfeeding or encourage parents to room-in with their newborns. Although these nonpharmacologic interventions appear to decrease the need for pharmacologic treatment and result in shorter hospitalizations, the interventions are heterogeneous and there are no high-quality clinical trials to support them. Regarding pharmacologic interventions, only 5 randomized clinical trials with prespecified sample size calculations (4 infant, 1 maternal treatment) have been published. Each of these trials was small (from\u200926 to 131 participants) and tested different therapies, limiting the extent to which results can be aggregated. There is insufficient evidence to support an association between any diagnostic or treatment approach and differential neurodevelopmental outcomes among infants with neonatal abstinence syndrome. Conclusions and Relevance Evidence pertaining to the optimal diagnosis and treatment strategies for neonatal abstinence syndrome is based on small or low-quality studies that focus on intermediate outcomes, such as need for pharmacologic treatment or length of hospital stay. Clinical trials are needed to evaluate health and neurodevelopmental outcomes associated with objective diagnostic approaches as well as pharmacologic and nonpharmacologic treatment modalities.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":4705740,"openaccessinfo":{"externalids":{"MAG":"2796095066","ACL":null,"DOI":"10.1097\/01.aoa.0000552878.14739.d6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Purpose. The purpose of this article is to reflect on the concept of habit as an under-explored, but critically important factor that might help explain the lack of uptake of new, scientifically sound practices by rehabilitation clinicians. Method. The complexity relating to being a scholarly practitioner is first presented. The transtheoretical model of behaviour change, developed to better understand behaviour change such as stopping a 'bad' habit or implementing a 'good' one for health improvement purposes, is used to foster reflection on factors involved in uptake of best practices in rehabilitation. To illustrate simply the different scenarios relating to uptake of best practices, such as the use of a standardised tool over a home-grown one, two well known approaches to assessment (use of thermometer versus hand on forehead) that could be used to assess the same construct (body temperature) are contrasted. Results. As rehabilitation clinicians, we are potentially blocked in our uptake of best practices by our habits. Although habits are often comfortable, and change is less so, we need to move away from our comfort zone if we are to adopt best practices. Conclusions. Given the extensive literature suggesting that there are major gaps between best practice and actual practices, it behoves us to explore the impact of habits to a greater extent.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21566942,"openaccessinfo":{"externalids":{"MAG":"2088493653","ACL":null,"DOI":"10.1080\/09638280902803773","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract : An experimental study has been conducted at the Air Force Research Laboratory at Edwards Air Force Base to explore the receptivity of cryogenic coaxial jet flows to transverse acoustic disturbances. The shear coaxial jet flow employed liquid nitrogen in the inner jet and cooled helium in the outer annular jet to represent the nominal fluid dynamical conditions of an oxygen\/hydrogen liquid rocket engine injector. The injector flow is submerged in a chamber that experiences a monotonic transverse acoustic resonance characteristic of a rocket chamber in the presence of combustion instability. The coaxial jet is exposed to a variety of acoustic conditions including different frequencies, amplitudes, and locations within the resonant mode shape. High-speed back-lit images were captured to record the behavior of the natural (unforced) and forced coaxial jets. Proper orthogonal decomposition and spectral analysis were used to extract natural and forced modes. Convective modes are extracted, and a new Strouhal number is used to characterize the dominant natural convective mode that is analogous to the preferred mode in free jets. The threshold of receptivity was found for a number of different injector flows and acoustic forcing conditions. The results indicate that the dimensionless frequency plays an important role, and there exists a finite forcing amplitude at which the threshold of receptivity occurs. The receptivity threshold and post receptivity response provides useful insight on the suitability of a given injector design for specific rocket combustion chamber conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26964417,"openaccessinfo":{"externalids":{"MAG":"2091766237","ACL":null,"DOI":"10.2514\/6.2014-3487","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An analog memory prototype containing 8*128 cells has been designed in a commercial quarter-micron CMOS process. The aim of this work is to investigate the possibility of designing large dynamic range mixed-mode switched capacitor circuits for high-energy physics (HEP) applications in deep submicron CMOS technologies. Special layout techniques have been used to make the circuit radiation tolerant. The memory cells employ gate-oxide capacitors for storage, permitting a very high density. A voltage write-voltage read architecture has been chosen to minimize the sensitivity to absolute capacitor values. The measured input voltage range is 2.3 V (the power supply voltage V\/sub DD\/ is equal to 2.5 V), with a linearity of almost 8 bits over 2 V. The dynamic range is more than 11 bits. The pedestal variation is \/spl plusmn\/0.5 mV peak-to-peak. The noise measured, which is dominated by the noise of the measurement setup, is around 0.8 mV rms. The characteristics of the memory have been measured before irradiation and after 100 kGy (SiO\/sub 2\/), and they do not degrade after irradiation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2555729,"openaccessinfo":{"externalids":{"MAG":"2156931751","ACL":null,"DOI":"10.1109\/23.940095","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/cds.cern.ch\/record\/521706\/files\/cer-002278353.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background Both under- and overinflation of endotracheal tube cuffs can result in significant harm to the patient. The optimal technique for establishing and maintaining safe cuff pressures (20\u201330\u2009cmH2O) is the cuff pressure manometer, but this is not widely available, especially in resource-limited settings where its use is limited by cost of acquisition and maintenance. Therefore, anesthesia providers commonly rely on subjective methods to estimate safe endotracheal cuff pressure. This study set out to determine the efficacy of the loss of resistance syringe method at estimating endotracheal cuff pressures. Methods This was a randomized clinical trial. We enrolled adult patients scheduled to undergo general anesthesia for elective surgery at Mulago Hospital, Uganda. Study participants were randomized to have their endotracheal cuff pressures estimated by either loss of resistance syringe or pilot balloon palpation. The pressures measured were recorded. Results One hundred seventy-eight patients were analyzed. 66.3% (59\/89) of patients in the loss of resistance group had cuff pressures in the recommended range compared with 22.5% (20\/89) from the pilot balloon palpation method. This was statistically significant. Conclusion The loss of resistance syringe method was superior to pilot balloon palpation at administering pressures in the recommended range. This method provides a viable option to cuff inflation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":3412041,"openaccessinfo":{"externalids":{"MAG":"2781235080","ACL":null,"DOI":"10.1155\/2017\/2032748","PubMedCentral":"5804330","ArXiv":null},"license":"CCBY","url":"http:\/\/downloads.hindawi.com\/journals\/arp\/2017\/2032748.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this study, we investigated the torque characteristics of large low-speed direct-drive permanent magnet synchronous generators with stator radial ventilating air ducts for offshore wind power applications. Magnet shape optimization was used first to improve the torque characteristics using two-dimensional finite element analysis (FEA) in a permanent magnet synchronous generator with a common stator. The rotor step skewing technique was then employed to suppress the impacts of mechanical tolerances and defects, which further improved the torque quality of the machine. Comprehensive three-dimensional FEA was used to evaluate accurately the overall effects of stator radial ventilating air ducts and rotor step skewing on torque features. The influences of the radial ventilating ducts in the stator on torque characteristics, such as torque pulsation and average torque in the machine with and without rotor step skewing techniques, were comprehensively investigated using three-dimensional FEA. The results showed that stator radial ventilating air ducts could not only reduce the average torque but also increase the torque ripple in the machine. Furthermore, the torque ripple of the machine under certain load conditions may even be increased by rotor step skewing despite a reduction in cogging torque.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12139378,"openaccessinfo":{"externalids":{"MAG":"2520664724","ACL":null,"DOI":"10.1631\/FITEE.1500238","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Author(s): Yu, Sooyoun | Advisor(s): Myung, Nosang V | Abstract: Electrospun nanofibers have gained great research interest for decades as attractive nanomaterial for various applications due to their ultra-high specific surface area, flexibility in materials, and ease of fabrication. Furthermore, fine tuning of electrospinning or post-electrospinning process conditions can allow for precise control of morphology, composition, physical, electrical, and electrochemical properties to tailor the nanofibers for a specific application. In this work, the effect of various electrospinning-related conditions on properties of polyacrylonitrile (PAN)-derived nanofibers was elucidated by series of systematic variation of parameters called design of experiment (DOE). Analyses on the DOE revealed solution viscosity, mainly controlled by polymer concentration, was the predominant factor for nanofiber morphology, while the addition of composite materials such as multi-walled carbon nanotubes and zinc acetate also strongly affected the nanofiber dimensions.To study the suitability of the PAN nanofibers with controlled properties for applications in energy harvesting and generation, piezoelectric and electrochemical properties of PAN-derived as-spun and heat-treated nanofibers were characterized. For the first time, size-dependent piezoelectric properties for PAN nanofibers was carefully investigated, which showed the voltage generated perpendicular to the direction of the fiber (V33) increased as a function of decreasing fiber dimensions, similar to more commonly studied piezoelectric polymers. Electroanalytical methods such as cyclic voltammetry, linear polarization and electrochemical impedance spectroscopy were employed to investigate the feasibility of various carbonaceous nanofibers as electrode material.Enzymatic fuel cell was chosen as the device of interest for energy generation application in this work. In an attempt to utilize the naturally abundant yet complex cellulose as fuel, a multienzyme cascade complex in nature called cellulosome was biomimetically fabricated by site-specific immobilization of 5 enzymes on customized DNA scaffold for sequential hydrolysis of cellulose followed by catalytic oxidation of glucose for electricity generation. With successful demonstration of the synergistic effect of enzyme immobilization on DNA scaffold, similar system was functionalized onto an electrode for preliminary electrochemical studies, which exhibited great promise as multienzyme cascade-based bioanode for cellulolytic fuel cell.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":234547861,"openaccessinfo":{"externalids":{"MAG":"3093855549","ACL":null,"DOI":"10.1149\/ma2020-02161468mtgabs","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/escholarship.org\/content\/qt01h168g7\/qt01h168g7.pdf?t=qijrlw","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The behavioral responses of three colonized strains of Culex quinquefasciatus, two from recent field collections in Thailand (Nonthaburi and Mae Sot) and one from a long-established colony from the National Institute of Health (NIH), Ministry of Public Health, Thailand, were compared during and after exposure to deltamethrin (0.02 g\/m2), propoxur (0.2 g\/m2), and fenitrothion (0.2 g\/m2) using an excito-repellency escape chamber system. We observed striking differences in behavioral response and excito-repellency between mosquito strains and test compounds. Greater escape responses were observed in the NIH strain during direct contact with deltamethrin and fenitrothion compared with the two field populations. Deltamethrin was the most irritant, followed by fenitrothion. Escape responses with propoxur were significantly delayed but increased slightly towards the end of the 30-min exposure period, more notably in the Nonthaburi strain (P<0.05). Non-contact repellent responses were generally much weaker than irritancy, with the greatest escape response seen with NIH and Nonthaburi. Deltamethrin showed the weakest repellent response overall (< 10% escape), while propoxur again demonstrated a delayed effect (NIH and Mae Sot) before escape occurred. We conclude that irritant and repellent behavioral responses by Cx. quinquefasciatus are important components for assessing the impact of residual spraying in mosquito control programs. A better understanding of chemical properties that elicit behavioral responses in mosquitoes should be considered in formulating control strategies designed to control mosquitoes or mitigate disease transmission risk.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23425546,"openaccessinfo":{"externalids":{"MAG":"2167961996","ACL":null,"DOI":"10.3376\/1081-1710(2006)31[266:SAABBC]2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Human immune serum recognition of outer membrane components from commensal and pathogenic Neisseria cultured under neutral and acidic conditions was investigated. Acid stress caused no detectable alterations in lipooligosaccharide migration and (or) staining, in outer membrane protein profiles, or in immune serum recognition of outer membrane components from Neisseria mucosa or Neisseria sicca. There was also no difference in the lipoologosaccharide electrophoretic pattern of acid- and neutral-grown Neisseria lactamica, but there were differences in outer membrane protein expression. The outer membrane protein alterations induced by acid stress in N. lactamica were not the same as those seen in isolates from patients with uncomplicated gonococcal infection, pelvic inflammatory disease, and disseminated gonococcal infection. Many differences were detected in the immune serum recognition of outer membrane components from acid- and neutral-cultured N. lactamica and from the clinical isolates of Neisseria gonorrhoeae, and these should be considered in vaccine design.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44439400,"openaccessinfo":{"externalids":{"MAG":"2071263701","ACL":null,"DOI":"10.1139\/CJM-47-9-871","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0Determining the ultimate cause and effect of millennial-scale climate variability remains an outstanding problem in paleoceanography, partly due to the lack of high-resolution records predating the last glaciation. Recent cores from Santa Barbara Basin provide ~2500\u20135700 year \"windows\" of climate with ~10\u201350 year resolution. Ages for three cores, determined by seismic stratigraphic correlation, oxygen isotope stratigraphy, and biostratigraphy, date to ~293 ka (MIS 8), ~450 ka (MIS 12), and ~735 ka (MIS 18). These records sample the Late Pleistocene, during which the 100 kyr cycle strengthened and the magnitude of glacial-interglacial cyclicity increased. Thus, these records provide a test of the dependence of millennial-scale behavior on variations in glacial-interglacial cyclicity. The stable isotopic (\u03b418O) composition of planktonic foraminifera shows millennial-scale variability in all three intervals, with similar characteristics (duration, cyclicity) to those previously documented during MIS 3 at this site. Stadial G. bulloides \u03b418O values are 2.75\u20131.75\u2030 (average 2.25\u2030) and interstadial values are 1.75\u20130.5\u2030 (average 1\u2030), with rapid (decadal-scale) interstadial and stadial initiations of 1-2\u2030, as in MIS 3. Interstadials lasted ~250\u20131600 years and occurred every ~650\u20131900 years. Stadial paleotemperatures were 3.5\u20139.5\u00b0C and interstadial paleotemperatures were 7.5\u201313\u00b0C. Upwelling, evidenced by planktonic foraminiferal assemblages and \u03b413C, increased during interstadials, similar to MIS 3; high productivity during some stadials was reminiscent of the Last Glacial Maximum. This study builds upon previous records in showing that millennial-scale shifts were an inherent feature of Northern Hemisphere glacial climates since 735 ka, and they remained remarkably constant in the details of their amplitude, cyclicity, and temperature variability.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129001098,"openaccessinfo":{"externalids":{"MAG":"1861409246","ACL":null,"DOI":"10.1002\/PALO.20022","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The article is devoted to analyzing the characteristic features and peculiarities of the organization and functioning of the \"Ukrsilprombud\" trust, as well as its role in the recovery and development of the economy and infrastructure in Sumy region in the post-war period.\nThe Republican Construction and Assembly Trust \"Ukrsilprombud\" existed during 1947-1954 and was an economic unit subordinated to the Ministry of Agriculture of the Ukrainian SSR. The trust specialized in constructing machine-tractor stations, machine-tractor workshops and other objects that were supposed to ensure the mechanization of agriculture.\nThe research highlights the formation and development of the organizational structure of the trust. The regional division of \"Ukrsilprombud\" \u2013 the Sumy Regional Construction and Installation Office \u2013 operated in Sumy oblast. The level of financing of this enterprise and the state of its provision of building materials and qualified personnel are characterized.\nIt was revealed that a lagging pace, non-fulfilment of plans, violation of the order and unevenness of work in the districts of Sumy region characterized the trust's participation in reconstruction. The leading cause of these phenomena was the ineffectiveness of the system of organizing the process at both the state and regional levels, manifested by insufficient funding, a lack of construction materials, a shortage and low qualification of workers. Sometimes the negative impact on the productivity of construction organizations was caused by a subjective factor \u2013 negligence and corruption on the part of managers.\nThe research is based on materials from the funds of the Central State Archives of Supreme Bodies of Power and Government of Ukraine and the State Archive of Sumy Region, as well as information from the local press issued in the late 1940s \u2013 early 1950s.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":259653292,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21272\/shaj.2023.i40.p.19","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.21272\/shaj.2023.i40.p.19","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Aims The aim of this study was to compare the rate of mortality and causes of death in Korean patients who undergo surgery for a fracture of the hip, up to 11 years after the injury, with a control group from the general population. Materials and Methods National cohort data from Korean Health Insurance Review and Assessment Service \u2010 National Sample Cohort were used. A ratio of 1:4 matched patients with a fracture who underwent surgery (3383, fracture group) between 2003 and 2012, and controls (13 532) were included. The matches were processed for age, gender, income, and region of residence. We also undertook analyses of subgroups according to age and gender. The mean follow\u2010up was 4.45 years (1 to 11). Results The prevalence of hypertension, diabetes, and stroke was significantly higher in the fracture group and dyslipidemia in the controls. Both crude and adjusted hazard ratios (HR) for the rate of mortality in the fracture group were > 2 (crude HR 2.03, 95% confidence interval (CI) 1.91 to 2.17, p < 0.001; adjusted HR 2.07, 95% CI 1.94 to 2.21, p < 0.001). The HRs were also > 2 for both men and women, and for both those aged \u2265 50 years and < 50 years. However, for those aged < 50 years, they were insignificant. The rates of mortality due to all 11 major causes of death classified following Korean standard classification of diseases were significantly higher in the fracture group compared with the control group, except those in the mental and behavioral disorders category. Conclusion The rate of mortality in the fracture group was significantly higher than in the control group up to 11 years after the surgery. The rate of death due to almost every major cause was significantly higher in the fracture group compared with the control group.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":4706206,"openaccessinfo":{"externalids":{"MAG":"2797262503","ACL":null,"DOI":"10.1302\/0301-620X.100B4.BJJ-2017-0993.R2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chromolaena odorata, Siam weed, a very important weed of Java Island (Indonesia) is native to Central and South America. In the laboratory it showed rapid growth (1.15 g\/g\/week) in the first 8 weeks of its growth. The biomass was mainly as leaves (LAR : 317.50 cm'\/g total weight). It slowed down in the following month as the biomass was utilized for stem and branch formation. This behavior supported the growth of C. odorata into a very dense stand. It flowered, fruited during the dry season, and senesced following maturation of seeds from inflorescence branches. These branches dried out, but soon the stem resumed aggressive growth following the wet season. Leaf biomass was affected by the size of the stem in its early phase of regrowth, but later on it was more affected by the number of branches. The introduction of Pareuchaetes pseudoinsulata to Indonesia, was successful only in North Sumatera. In Java it has not been reported to establish succesfully. The introduction of another biological control agent, Procecidochares conneca to Indonesia was shown to be specific and upon release in West Java it established immediately. It spread exponentially in the first 6 months of its release. Field monitoring continues to evaluate the impact of the agents. Other biocontrol agents (Actmole anteas and Conotrachelus) wilt be introduced to Indonesia in 1997 through ACIAR Project on the Biological Control of Chromolaena odorata in Indonesia and Papua New Guinea. Keywords: Indonesia \/ North Sumatra \/ West Java \/ Biological control \/ Chromolaena odorata i Pareuchaetes pseudoinsulata I Procecidochares conneca.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":83515313,"openaccessinfo":{"externalids":{"MAG":"1939531574","ACL":null,"DOI":"10.11598\/BTB.1998.0.11.140","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Returning to sport following an injury is a process that is riddled with difficulties, especially so for competitive athletes. This is a quantitative research employed survey method. A total of 130 cheerleaders (age = 25.66 \u00b1 4.928 years old) participated in this study where they have suffered from an injury that has put them out from sports for 1 4 weeks. Two inventories were completed: 1) Adapted Sport Motivation Scale and 2) Readiness to Return to Sport Questionnaire. The demographic data collected were age, team cheer division, position in team and injury duration. Descriptive statistics and inferential statistics (Pearson product-moment correlation, Independent T-test and One-way ANOVA) were used to analyze the data. Results from the study showed that there were significant effects (p <0.05) of intrinsic motivation (toward accomplishment and experience stimulation) and extrinsic motivation (identified regulation, introjected and external regulation) of athletes towards returning to sport after injury. This demonstrated that motivation significantly influenced athletes' readiness to return to sport following an injury. Correlation analyses revealed that the effects of intrinsic and extrinsic motivation towards athletes' readiness to return to sports following injury were associated with a positive renewed perspective on engaging in sports. As the athletes perceived themselves to be psychologically ready to return to sport after injury; it also reflected on their self-determination to attempt the sport again without fear, worry, concern and anxiety of reinjure from occurring. This study indicated the importance of motivation in assisting injured athletes in returning to sport. Most athletes returned to sport because of others' expectations on themselves although they were not fully mentally prepared to return to sport due to their fear and concerns of performing at peak performance again.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":233601489,"openaccessinfo":{"externalids":{"MAG":"3146407293","ACL":null,"DOI":"10.15282\/MOHE.V10I1.496","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The hydrolytic stability of polymers to be used for coatings in aqueous environments, for example, to confer anti-fouling properties, is crucial. However, long-term exposure studies on such polymers are virtually missing. In this context, we synthesized a set of nine polymers that are typically used for low-fouling coatings, comprising the well-established poly(oligoethylene glycol methylether methacrylate), poly(3-(N-2-methacryloylethyl-N,N-dimethyl) ammoniopropanesulfonate) (\"sulfobetaine methacrylate\"), and poly(3-(N-3-methacryamidopropyl-N,N-dimethyl)ammoniopropanesulfonate) (\"sulfobetaine methacrylamide\") as well as a series of hitherto rarely studied polysulfabetaines, which had been suggested to be particularly hydrolysis-stable. Hydrolysis resistance upon extended storage in aqueous solution is followed by 1H NMR at ambient temperature in various pH regimes. Whereas the monomers suffered slow (in PBS) to very fast hydrolysis (in 1 M NaOH), the polymers, including the polymethacrylates, proved to be highly stable. No degradation of the carboxyl ester or amide was observed after one year in PBS, 1 M HCl, or in sodium carbonate buffer of pH 10. This demonstrates their basic suitability for anti-fouling applications. Poly(sulfobetaine methacrylamide) proved even to be stable for one year in 1 M NaOH without any signs of degradation. The stability is ascribed to a steric shielding effect. The hemisulfate group in the polysulfabetaines, however, was found to be partially labile.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":52490472,"openaccessinfo":{"externalids":{"MAG":"2805336342","ACL":null,"DOI":"10.3390\/POLYM10060639","PubMedCentral":"6403559","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The symptoms and anatomical structure of loquat seedlings, which were planted in pots on K,P,Ca deficiency, were studied. The activity of root, the leaf content of chlorophyll and photosynthesis were measured. The results showed: the seedling leaves of P-deficiency were in dark green and photosynthesis was less than that of controlled seedling; veins of leaves were purple-red. There were some yellow scars on the leaves of those seedlings caused by deficiency of K; the content of chlorophyll was significantly lower than that of others and the photosynthesis was the lowest. The seedlings with Ca-deficiency were undersized; the leaves were deformed, small and the color of leaf edge was yellow; the root system was not developed well.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209295562,"openaccessinfo":{"externalids":{"MAG":"1026417816","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Well preserved transitional cells were found between differentiated cells and horny cells of the frog epidermis, thus facilitating the study of the sequential events involved in horny cell formation. Autolysosomes appear to play an important role in the formation of horny cells. These structures preferentially digest those cytoplasmic components which are not necessary constituents of the terminal horny cell. The release of the contents of the small mucous granules into the intercellular spaces is one of the initial events in horny cell formation. Filaments and large mucous granules seem to be resistant to the lytic digestion and contribute to the bulk of the horny cell. Loss of fluids through the plasma membrane and consolidation of the remaining constituents, results in a flattened horny cell. The appearance of a thickened membrane around the horny cell signifies the completion of the transformation process.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":10801055,"openaccessinfo":{"externalids":{"MAG":"2012391451","ACL":null,"DOI":"10.1002\/jmor.1051420402","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Should your PhD sacrifice your mental health? Seems like a silly question to ask in 2020, maybe even rhetorical to some. However, a great deal of postgraduate researchers experience mental health issues as an unwanted by-product of their PhD. At what point does this become too much? Mental health has become one of the biggest issues put under the public spotlight in recent years, so why do we still have this archaic culture in academia? Maybe it is time for a change in how we think about what is and is not acceptable, and what resources are available to those of us who find ourselves struggling with our mental health during our research.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":216297777,"openaccessinfo":{"externalids":{"MAG":"3015006078","ACL":null,"DOI":"10.1042\/bio04202010","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1042\/bio04202010","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":": The implications of AIDS for health care are unknown. Precise data about the extent to which patients appeal to hospital health care facilities and resulting costs are not available, mainly due to the absence of suitable methods for the registration of demographic, medical and financial data on individual patients in hospitals. In this paper we present the preliminary results of application of a new system which allows such a detailed collection and analysis of data. By evaluating patients with HIV infections treated in the University Hospital Utrecht between January 1, 1987 and July 1, 1988, the mean yearly costs of in- and outpatient treatment of a patient with AIDS (CDC-IV) were found to be Dfl. 40,267.-; those of treatment of patients with other HIV infections ranged from Dfl. 3,629.-(CDC-III) to Dfl. 5,115.-(CDC-II). Comparison of the mean costs for patients who died in that period with those for patients who did not, reveals that patients dead of AIDS would have cost Dfl. 75,289.-yearly and those with AIDS who were alive at July 1, 1988 Dfl. 27,308.-.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":68216024,"openaccessinfo":{"externalids":{"MAG":"40215821","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We introduce the subspace density matrix functional embedding theory (sDMFET), in which optimization of the nonlocal embedding potential and subsequent embedded correlated wave function calculations are carried out within a truncated subspace determined by a Schmidt decomposition. As compared to the original density matrix functional embedding theory [K. Yu and E. A. Carter, Proceedings of the National Academy of Sciences 2017 , 114 , E10861 ], the computational cost of sDMFET is significantly reduced while the accuracy is preserved. We perform test calculations for both covalently and noncovalently bound molecular systems to demonstrate the feasibility of our theory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58656746,"openaccessinfo":{"externalids":{"MAG":"2906190043","ACL":null,"DOI":"10.1021\/acs.jctc.8b00990","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/biblio\/1813038","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The real-time control system (RCS), reference model architecture for intelligent control systems has been used for the design and implementation of a wide variety of intelligent systems applications. The RCS reference model architecture defines hierarchical heterogeneous layers of control. Each layer has characteristic timing and bandwidth of sensory processing and servo control loops. Each layer also has characteristic range and resolution of world model maps, and characteristic spatial-temporal range and resolution of goals and plans. Each layer consists of one or more computational nodes, and each node contains sensory processing, world modeling, and task decomposition modules. These modules are interconnected within the nodes and the nodes are interconnected within and between layers by a communications system that provides database services and message passing functions. The RCS reference model is currently being used as a control system architecture for the US Army\/Marine Corps unmanned ground vehicle Robotics Testbed vehicle. This paper suggests how the RCS reference model architecture might be adopted for the design of advanced vehicle control systems, and for advanced traffic management systems, and for advanced traveler information systems.<>","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":111062669,"openaccessinfo":{"externalids":{"MAG":"2145070573","ACL":null,"DOI":"10.1109\/IVS.1992.252289","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to synthesis ternary hybrid composite PMMA polymer matrix with TiO2, Al2O3 and ZrO2 as additives using casting technique. Range of weight fractions (84-92 wt %) of Poly (methyl methacrylate), fixed percentage (4%) of TiO2 and range of weight fractions (4-12 wt %) of Al2O3 and ZrO2 were used as started materials. Structure characterization was examined through XRD and AFM. Obtained micrograph revealed homogeneity structure and XRD pattern display present of crystals for ZrO2. Dielectric properties like dielectric constant were carried out for range (10-10) Hz frequency .The addition of Alumina filler exhibit slightly effect on values of dielectric constant for prepared ternary hybrid composite (PMMA-TiO2-Al2O3) compared with ZrO2 for ternary hybrid composite (PMMA-TiO2-ZrO2) which dielectric constant increase as concentration . Dissipation factor decrease with increasing frequency in composite of alumina and zirconia but in case the later yield good compatible. D.C electrical conductivity was conducted at temperature range (313-373) K. Markedly increasing of the D.C electrical conductivity for Zirconia filler respect to addition concentration and applied temperature.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":136381732,"openaccessinfo":{"externalids":{"MAG":"2589080692","ACL":null,"DOI":"10.22401\/JNUS.19.2.12","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper develops an economic theory of empire building. This theory addresses the choice among three strategies that empire builders historically have used. We call these strategies Uncoerced Annexation, Coerced Annexation, and Attempted Conquest. The theory shows how the choice among these strategies depends on such factors as the economic gains from imperial expansion, the relative effectiveness of imperial armies, the costs of projecting imperial military power, and liquidity constraints on financing imperial armies. This theory also addresses the scope of imperial ambitions. The paper uses examples from the history of the Roman, Mongol, Ottoman, and Nazi German empires to illustrate the applicability of the theory.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":16944206,"openaccessinfo":{"externalids":{"MAG":"2950742293","ACL":null,"DOI":"10.2139\/ssrn.310602","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/papers.nber.org\/papers\/w8109.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Borel summation techniques are developed to obtain exact invariants from formal adiabatic invariants (given as divergent series in a small parameter) for a class of differential equations, under assumptions of analyticity of the coefficients; the method relies on the study of associated partial differential equations in the complex plane. The type and location of the singularities of these associated functions, important in determining exponentially small corrections to formal invariants are also briefly discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250844673,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0951-7715\/17\/4\/019","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arxiv.org\/pdf\/math\/0608315","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Andrew M Aneese Justine A Nasr Alexandra Halalau 1Department of Internal Medicine, Beaumont Health, Royal Oak, MI 48073, USA; 2Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA Introduction: Evidence based medicine (EBM) skills are often lacking in the general internal medicine physician population. Our aim is to evaluate the impact of our internal medicine EBM curriculum on the residents' EBM skills and knowledge through mixed methods. Methods: A prospective study was performed that evaluated the EBM curriculum: quantitatively, with pre\/posttests and qualitatively through a focus group that addressed residents' opinion on the educational and clinical impact of each aspect of the curriculum. Results: A total of 60 internal medicine residents were surveyed. Short-term EBM skills: therapy workshops (N=25) median pretest score of 8 (IQR): [6\u20139]) vs posttest 8 (IQR: [8\u20139]), (p=0.006); diagnosis (N=16) pretest score of 6 (IQR: [3\u20136]) vs posttest 7 (IQR: [6\u20139]), (p=0.006); systematic review (N=13) pretest score of 4 (IQR: [4\u20136]) vs posttest 7 (IQR: [6\u20138]), (p=0.002); and harm (N=16) pretest score of 6 (IQR: [5\u20137]) vs posttest 7 (IQR: [7\u20138]), (p=0.004). Long-term EBM skills: Fresno test of competence in EBM, pretest median score of 110.5\/212 (IQR: 96.0\u2013124.0) and a median posttest score of 115\/212 (IQR: 100.0\u2013130.0) (p=0.60). Having previous EBM training, being actively involved in research and being the first author on a publication was associated with higher Fresno test scores. Focus group provided qualitative feedback on the residents' EBM curriculum perception. Conclusion: This curriculum adds a significant contribution to the current field of medical education as it fills an important educational gap, through defining ways of effectively delivering EBM concepts which led to improvement in residents' ability to evaluate and apply medical literature. The EBM curriculum was overall well received by the residents.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208051329,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recent advances in our understanding of the boundary layer and cumulus convection in the tropics are reviewed. The review reflects the interactive nature of the atmosphere-ocean system. It discusses the observational picture of the atmosphere that is emerging from tropical field experiments, results of diagnostic studies of convective transports and structure, and the progress in both modeling and parameterizing convection and the tropical boundary layer.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":121124231,"openaccessinfo":{"externalids":{"MAG":"2021761729","ACL":null,"DOI":"10.1175\/1520-0477(1974)055<1195:AROTTB>2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Wood is among the most universe substantial resources and one of the main common kinds of occupational exposure. For this , the research goal was the assess of the genotoxicity effects of wood dust exposure for some Iraqi workers employed in a wooden furniture factories using alkaline comet assay based on measuring the DNA damage that occurred in the white blood cells (WBC) , aimed to minimize the health risks from dangerous substances in the workplace. Fifty workers in a wooden furniture factories and 50 apparently healthy control were used in this study. DNA damage was significantly higher in the wood's workers , than in the control subjects according to the comet parameters. Thus , significantly higher levels of DNA damage observed in wood's workers in whom either smoked ( tail length 40.15 \u00b1 0.54; tail DNA % 32.12 \u00b1 0.87 and tail moment 12.90 \u00b1 0.98) or non-smokers (tail length 36.21 \u00b1 0.43 ; tail DNA % 29.56 \u00b1 0.34 and tail moment 10.70 \u00b1 0.10) than in smoker (tail length 12.81 \u00b1 0.89; tail DNA % 6.60 \u00b1 0.06 and tail moment 0.846 \u00b1 0.02) and nonsmokers (tail length 2.63 \u00b1 0.33 ; tail DNA % 2.29 \u00b1 0.07 and tail moment 0.060 \u00b1 0.03) of control group. Present study deduce the relationship of the exposure to wood dust with high level of DNA damage. In conclusion, the results indicated that there was a possibility of using the changes in the level of comet assay as try for the detection of DNA damage of workers employed in a wooden furniture factories . Also, the results obtaining was confirmed by usefulness of the alkaline comet assay as a sensitive additional marker in the regular health screening of workers occupationally exposed to dangerous wooden dust .","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219685847,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Policy implementation is a complex process and the theoretical problem has been approached in different ways for a long time. Perspectives have converged around governance, negotiation and adaptation and the learning perspective is increasingly acknowledged. This paper explores how policy implementation may be understood from a learning perspective, affected by universal tendencies for humans to draw biased conclusions from specific events. The Advocacy Coalition Framework is used as a point of reference when applying concepts of learning and decision-making biases and heuristics. From a set of three separate events of a continuous implementation of the 1994 LSS Act (The Act Concerning Support and Service for Persons with Certain Functional Impairments), empirical illustrations are forwarded based on both primary and secondary data sources. The paper contributes to the field of policy implementation, first of all, with authentic empirical representations of policy implementation as a learning process. Second, the paper supports the ACF learning tenets about the importance of actors, forums, conflicts, and stimuli. Thirdly, it indicates that ignoring the inherent human tendencies of biased decision- making may leave explanations and understanding of policy implementation incomplete","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":145042339,"openaccessinfo":{"externalids":{"MAG":"2747295555","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The isoelectronic In-doping effect in GaN films grown by metalorganic chemical vapor deposition was investigated by using Raman scattering, scanning electron microscopy (SEM), and x-ray and photoluminescence (PL) measurements. In our study, the phonon spectra of films remain sharp without alloy formation after incorporation of small amounts of In atoms. The SEM pictures of the sample surface reveal greatly reduced nanopits indicating better surface flatness that is also supported by the multiple interference effect in the PL signals. More importantly, isoelectronic doping has caused the linewidth at 15 K of the near-band-edge emission of GaN to decrease sharply to 10 meV or less, reflecting improved optical property.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":121489207,"openaccessinfo":{"externalids":{"MAG":"2022721886","ACL":null,"DOI":"10.1063\/1.121933","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nTo determine the accuracy of diagnosis of ophthalmic disorders as well as the adequacy of referral of patients with ophthalmic disorders for specialist eye care by the general practitioners (GP).\n\n\nMATERIALS AND METHODS\nThis was a hospital-based descriptive study. Patients selected by systematic random sampling at the General Out-Patient Department (GOPD) of a tertiary hospital were evaluated by the ophthalmologist after they had been independently assessed by the General Practitioners. Diagnoses and referral decisions of the GP were compared with those of the ophthalmologist using Kappa Statistics.\n\n\nRESULTS\nA total of 382 patients were studied while 22 GPs participated in the study. Ocular disorders were found by the ophthalmologist in 112 (29.3%) patients while the remaining 270 (70.7%) were normal . Only 36 (32.1%) of those with ocular disorders had a diagnosis of ocular disorders by the General Practitioners. A correct diagnosis was made by the GPs for 18 (16.1%) patients (k=0.102, p =0.001); and the highest diagnostic agreement was obtained for conjunctivitis (k=0.464, P= 0.001). No patient with posterior segment disorder was diagnosed by the GPs. Majority (81%; k = 0.616, p=0.001) of referrals were in agreement with expected referral decision. However, 28 (25.0%) under-referrals and 16 (19.0%) over-referrals were noted.\n\n\nCONCLUSION\nAbout one-third of all the patients assessed had an ocular disorder, but the general practitioners detected these disorders only one-third of the time; a correct diagnosis of ocular disorders was made in only 16.1%, while no posterior segment disease was diagnosed. Wrong referral decisions were made in up to one-third of patients. Regular update courses for general practitioners on ophthalmic evaluation will help address these observed deficiencies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249988472,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"While alliances continue to be an important tool for airlines as they seek to expand their networks to compete more effectively with other larger networks, the effects of alliances and market liberalization on air transport market competition and airline performance have received relatively little attention. This research empirically investigates the effects of liberalization, and airline alliances, on airline competition. The analysis is based on 5,021 data sets focusing on 197 routes between the gateway cities of the major airlines' home countries. Findings show that airline passenger market share and route network share are significantly increased with increasing alliance activity. Also, airlines have a greater number of flights, passengers and passenger seats on routes for which they are involved in higher levels of cooperation and operate in more liberal markets. This suggests that multiple cooperation structures contribute more than bilateral airline service agreements to the overcoming of restrictive regulatory frameworks, enabling more effective competition.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":154581637,"openaccessinfo":{"externalids":{"MAG":"2054984112","ACL":null,"DOI":"10.5367\/000000004773166501","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5367\/000000004773166501","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Aim. To study cytokine status in patients with chronic obstructive pulmonary disease (COPD) and its interrelations with bone metabolism.\nMaterial and methods. The levels of pro-inflammatory and anti-inflammatory cytokines, bone metabolism markers in the blood were evaluated in 80 patients with COPD.\nResults. Changes in cytokine status in COPD patients was established: an increase in pro-inflammatory cytokines and change in anti-inflammatory cytokines. There was hyperproduction of serum proinflammatroy cytokines (IL-lp, IL-6, 1L-8, TNF-a) dependent on FEV1. IL-10 was markedly elevated (p 0.05) in patients with COPD. A correlation analysis showed a positive correlation between IL-10, IL-4 and FEV1; IL-10, IL-4 and osteocalcine (bone formation marker), pro-inflammatory cytokines (IL-ip, IL-6 and TNFa) and Crosslaps (bone resorption marker). A negative correlation was discovered between IL-lp, TNFa and body mass index; IL-8 and osteocalcine.\nConclusion. A significant role of cytokine-mediated mechanism in pathogenesis of pulmonogenic osteopenia.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238503208,"openaccessinfo":{"externalids":{"MAG":"3028853583","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present study aimed to investigate the possible morphological and skeletal fetotoxicity of the new antiepileptic drug, gabapentin (GBP) during the organogenesis phase of the rat embryonic development and to examine the possible ameliorative role of ginger (Zingiber officinale). Morphologically, there was evident growth retardation and a high frequency of malformations in the skin, head, trunk, limbs and tail of fetuses maternally injected with GBP. Skeletal investigation revealed that rat fetuses of the GBP group exhibited delayed ossification and various skeletal malformation. Limb deformities was the most prominent feature observed followed by coastal malformations, vertebral deformities, skull anomalies and sternal defects, respectively. The most evident skull malformation was maxillary and mandibular hypoplasia. Ginger extract caused an evident decrease in GBP-induced fetotoxicity at the investigated parameters. In conclusion, treatment with GBP should be approached with highly caution during pregnancy and ginger is recommended to be taken in parallel for its ameliorative role in this regard.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":182027978,"openaccessinfo":{"externalids":{"MAG":"2946461322","ACL":null,"DOI":"10.33980\/AJABS.2019.V07I01.001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Herbaspirillum frisingense strain ureolyticus VT-16-41 is a clinical cystitis isolate. Here, we report the draft genome sequence of the uropathogenic H. frisingense strain ureolyticus VT-16-41, which contains various antibiotic resistance genes and virulence factors that enable it to colonize and persist in the urinary tract.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1933211,"openaccessinfo":{"externalids":{"MAG":"2608870066","ACL":null,"DOI":"10.1128\/genomeA.00279-17","PubMedCentral":"5408125","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"MicroRNAs (miRNAs) are well established as global gene regulators and thus, slight alterations in miRNA levels as well as their ability to regulate their targets may cause important cellular changes leading to cancer risk. 3\u00b4 untranslated region (UTR) miRNA binding site single nucleotide polymorphisms (SNPs) have added another layer of possible genetic variation involved in the complex process of oncogenesis. Identifying these key genetically inherited effectors of miRNA functioning has improved our understanding of the complexity of disease. Interest in the field has grown rapidly in only the last 5 years, with several studies reporting on the role of 3\u00b4UTR binding site SNPs as genetic markers of increased cancer susceptibility, as well as biomarkers of cancer type, outcome and response to therapy. Currently, there are numerous known miRNA binding site SNPs associated with multiple cancer subtypes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207219402,"openaccessinfo":{"externalids":{"MAG":"2013241897","ACL":null,"DOI":"10.1586\/erm.10.59","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3832135?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper explores the tensions and complexities for two principals as they work towards equity and improved social and educational outcomes for their Indigenous students. Drawing on Foucault's fourfold ethical frame and poststructuralist notions of the subject, this paper presents the different ways the white female principals of Indigenous schools are formed as subjects. We illustrate how the multiplicities of their subject formation are influenced by the historicity and contextual factors of the schools and communities. These factors play a significant part in how these principals work as advocates and differently experience and negotiate the tensions around representation of and for Indigenous schools and communities. In realising equity goals for Indigenous students, the paper draws on Foucault's work to illustrate the imperative of school leaders' cognisance of, and capacity to work with, these factors.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":143060372,"openaccessinfo":{"externalids":{"MAG":"1965235460","ACL":null,"DOI":"10.1080\/09518398.2013.771223","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Proc Amer Assoc Cancer Res, Volume 47, 2006\n\n4691 \n\nMutations in the TP53 tumor suppressor gene occur in approximately 20% Diffuse Large B-cell Lymphoma (DLCBL) and are associated with resistance to doxorubicin-containing combination chemotherapies and a more aggressive clinical course. TP53 mutations also result in resistance to DNA damaging drugs in vitro, in part, through activation of G2 checkpoint kinases and a G2\/M arrest that is essential for recovery from genotoxic stress. Therefore, abrogation of G2\/M arrest may result in sensitization of p53-deficient tumor cells to chemotherapeutic agents. Heat-Shock Protein 90 (HSP90) is a major molecular chaperone involved in the conformational folding of many cellular proteins. HSP90 inhibitors, the naturally occurring ansamycin antibiotic geldanamycin (GA) and its derivatives, 17-Allylamino-17-Demethoxygeldanamycin (17-AAG) and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), bind the ATP-binding pocket of HSP90 and inhibit the essential ATPase activity, leading to destabilization and eventual degradation of HSP90 client proteins. It is becoming apparent that inhibition of HSP90 may provide an advantage over single-target agents for the treatment of tumors bearing multiple oncogenic mutations. Furthermore, 17-AAG and 17-DMAG have been shown to be effective, alone or in combination with other agents, in preclinical models of cancer, and are currently in Phase I\/II clinical trials. We found that human lymphoblastoid cells expressing wild type p53 underwent apoptosis in response to Doxorubicin, whereas cells that lack functional p53 and DLBCL with mutant p53 accumulated in G2\/M. Addition of low concentrations of HSP90 inhibitors after Doxorubicin had a synergistic effect, resulting in significant increase in cell death and abrogation of G2\/M arrest. Addition of both drugs simultaneously or in reverse order resulted in only additive or even moderately antagonistic response on cell survival. Consistent with checkpoint activation upon DNA damage, the checkpoint kinases, CHK1 and CHK2, were phosphorylated in response to Doxorubicin, but their expression decreased after exposure to 17-DMAG alone and they were further degraded by combination therapy. These data indicate that chemotherapy-resistant tumors that lack functional p53 and rely on G2\/M arrest can be forced into apoptosis by inhibition of checkpoint kinases. Our study offers insight into the molecular pathways underlying sensitization of p53 mutant DLBCL to HSP90 inhibitors and provides a guiding principle supporting the design of clinical trials for combination therapy.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":82261162,"openaccessinfo":{"externalids":{"MAG":"1555114806","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mastery of mathematics depends on the people's ability to manipulate and abstract values such as negative numbers. Knowledge of arithmetic principles does not necessarily generalize from positive number arithmetic to arithmetic involving negative numbers (Prather & Alibali, 2008, https:\/\/doi.org\/10.1080\/03640210701864147). In this study, we evaluate the relationship between participant's knowledge of the Relation to Operands arithmetic principle in both positive and negative numbers and their spontaneous on numerical relations. Additionally, we tested if the feedback that directs attention to relations affects participants' attention to relation and their arithmetic principle knowledge. This study contributes to our understanding of the specific skills and cognitive processes that are associated with understanding high-level mathematics.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":260364740,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5964\/jnc.10057","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/jnc.psychopen.eu\/index.php\/jnc\/article\/download\/10057\/10057.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Glucose transporter protein type 1 deficiency syndrome is a metabolic disorder manifesting as cognitive impairment, acquired microcephaly, epilepsy, and\/or movement disorder caused by mutations in the SLC2A1 gene. We describe a cohort of isolated and familial cases of glucose transporter protein type 1 deficiency syndrome, emphasizing seizure semiology, electroencephalographic (EEG) features, treatment response and mutation pathogenicity. SLC2A1 mutations were detected in 3 sporadic and 4 familial cases. In addition, mutations were identified in 9 clinically unaffected family members in 2 families. The phenotypic spectrum of glucose transporter protein type 1 deficiency is wider than previously recognized, with considerable intra-familial variation. Diagnosis requires either hypoglycorrachia followed by SLC2A1 sequencing or direct gene sequencing. A ketogenic diet should be the first line of treatment, but more flexible diets, like the Atkins modified diet, can also be followed. Carbonic anhydrase inhibitors, such as acetazolamide or zonisamide, can be effective for seizure control.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":860096,"openaccessinfo":{"externalids":{"MAG":"2040312782","ACL":null,"DOI":"10.1177\/0883073812471718","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Improved control of prosthetic voice aids for laryngectomees might be possible to obtain with residual laryngeal motor nerve signals. We were able to recover motor signals from the recurrent laryngeal nerve (RLN) by transposing it into the ipsilateral denervated sternohyoid muscle (SH) in 8 guinea pigs. Reinnervation was monitored by electromyographic recordings from surface and intramuscular needle electrodes in awake animals. Within 4 to 14 weeks after surgery, all animals demonstrated laryngeal-like motor activity in the reinnervated SH, including activity during respiration, sniffing, swallowing, and\/or vocalizing. After 3 to 6 months, the animals were reanesthetized, and nerve stimulation and section experiments confirmed the RLN as the source of reinnervation in all cases. In several animals, activity of the RLN-innervated SH was demonstrated to be correlated with that of contralateral laryngeal muscles. Histochemical analysis of the SH indicated a unilateral transformation from mostly fatigable to mostly fatigue-resistant fiber types ipsilateral to the RLN transposition, a phenotype more typical of laryngeal muscles. Thus, RLN transposition at the time of laryngectomy may be a method for salvaging laryngeal control signals that could be used to control prosthetic voice devices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44397793,"openaccessinfo":{"externalids":{"MAG":"1968545960","ACL":null,"DOI":"10.1177\/000348940010901012","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: HFNO is considered as a treatment option in patients with de novo AHRF prior to intubation or where admission to ICU is deemed inappropriate.We retrospectively reviewed the clinical outcomes of all patients who received NHFO over 12 months in our ARCU. Method: Patients identified from the admission database were evaluated for length of stay(LOS),duration of HFNO,clinical outcome,in-hospital and 90-day mortality.A subgroup analysis between the survivors and non survivors was done to evaluate for any predictive parameters. Results: 71 patients [age-72 +\/-13,males-68%] were included.90% (n=64) had significant co-morbidities (cardio-respiratory, metabolic and malignancy).Diagnosis on admission was Pneumonia(76%), Pulmonary Oedema(11%),Pulmonary Embolism(6%),ILD(6%) and Pneumothorax(1%).72% were not for escalation to level 3 care and had an active Do not resuscitate status.The median LOS on ARCU was 4 (2-8) days and median duration of HFNO was 3 (2-6) days.86% (n=61) had HFNO only,8%(n=6) were escalated to CPAP\/NIV,3% (n=2) were transferred to ICU.The in hospital and 90 day mortality was 42% and 63%. Subgroup analysis between survivors and non survivors showed no significant difference in age(71 +\/-12 v\/s 73 +\/-14,P=0.5),gender(P=0.61,OR=0.41),WHO PS(P=0.15,OR=0.95),RR(25 +\/-6 v\/s 26+\/-5, P= 0.34) and PO2(7.8 +\/-1.6 v\/s 7.4 +\/-1.4,OR=0.22). Conclusions: HFNO can be an option both in de novo AHRF and in patients who are deemed not for invasive ventilation.Patients with ILD subgroup have a high failure rates with worse mortality and early palliation may be beneficial.Further large scale studies are warranted to evaluate the role of NHFO in ILD.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":235499845,"openaccessinfo":{"externalids":{"MAG":"3157796794","ACL":null,"DOI":"10.1183\/23120541.SLEEPANDBREATHING-2021.57","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The media often link Black characters and violence. This is especially true in video games, in which Black male characters are virtually always violent. This research tested the effects of playing a violent game as a Black (vs. White) avatar on racial stereotypes and aggression. In Experiment 1, White participants (N = 126) who played a violent video game as a Black avatar displayed stronger implicit and explicit negative attitudes toward Blacks than did participants who played a violent video game as a White avatar or a nonviolent game as a Black or White avatar. In Experiment 2, White participants (N = 141) who played a violent video game as a Black (vs. White) avatar displayed stronger implicit attitudes linking Blacks to weapons. Implicit attitudes, in turn, related to subsequent aggression. Black violent video game avatars not only make players more aggressive than do White avatars, they also reinforce stereotypes that Blacks are violent.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":44058340,"openaccessinfo":{"externalids":{"MAG":"2122401267","ACL":null,"DOI":"10.1177\/1948550614528008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT\n The growth of the global video game industry has resulted in an inflow of new entrants who aspire to create novel video games and preferably new video game genres. From an empiricist perspective presented by Gilles Deleuze, a video game is an agencement that materialize on the basis of the relations between the elements included in the game (e.g. computer code, game design ideas, the narrative structure of the game, interface design, etc.). A study of indie video game developers examines how the video game as agencement is composed of technical and narrative elements, and how the subject-formation process of the developer is bound up with the creation of video games. That is, indie video game developers are part of the creative work to develop new digital artefacts that per se are relational and composite in nature, as premised by the concept of agencement.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":236633168,"openaccessinfo":{"externalids":{"MAG":"3170685057","ACL":null,"DOI":"10.1080\/14759551.2021.1919893","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14759551.2021.1919893?needAccess=true","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The study was carried out to examine participants of current war conflicts and World War II in order to compare the development of the formation of stereotype of old age. It was established that participants of World War II have higher level of the formation of pessimistic stereotype of old age than participants of current war conflicts have.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36662151,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Learning to race autonomously is a challenging problem. It requires perception, estimation, planning, and control to work together in synchronization while driving at the limit of a vehicle's handling capability. Among others, one of the fundamental challenges lies in predicting the vehicle's future states like position, orientation, and speed with high accuracy because it is inevitably hard to identify vehicle model parameters that capture its real nonlinear dynamics in the presence of lateral tire slip. We present a model-based planning and control framework for autonomous racing that significantly reduces the effort required in system identification. Our approach bridges the gap between the design in a simulation and the real world by learning from on-board sensor measurements. Thus, the teams participating in autonomous racing competitions can start racing on new tracks without having to worry about tuning the vehicle model.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1}},"corpusid":218581432,"openaccessinfo":{"externalids":{"MAG":"3023209277","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2005.04755"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many tasks in natural language processing involve predicting structured outputs, e.g., sequence labeling, semantic role labeling, parsing, and machine translation. Researchers are increasingly applying deep representation learning to these problems, but the structured component of these approaches is usually quite simplistic. In this work, we propose several high-order energy terms to capture complex dependencies among labels in sequence labeling, including several that consider the entire label sequence. We use neural parameterizations for these energy terms, drawing from convolutional, recurrent, and self-attention networks. We use the framework of learning energy-based inference networks (Tu and Gimpel, 2018) for dealing with the difficulties of training and inference with such models. We empirically demonstrate that this approach achieves substantial improvement using a variety of high-order energy terms on four sequence labeling tasks, while having the same decoding speed as simple, local classifiers. We also find high-order energies to help in noisy data conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":222141642,"openaccessinfo":{"externalids":{"MAG":"3092283719","ACL":"2020.emnlp-main.449","DOI":"10.18653\/v1\/2020.emnlp-main.449","PubMedCentral":null,"ArXiv":"2010.02789"},"license":"CCBY","url":"https:\/\/www.aclweb.org\/anthology\/2020.emnlp-main.449.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The Lecroq algorithm is the best current solutions of single pattern string matching for binary text. In this paper, we simplify Lecroq and propose a more practical variant which is named S-Lecroq. We analysis the complexity of S-Lecroq and proof that S-Lecroq is optimal in average.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15067106,"openaccessinfo":{"externalids":{"MAG":"2086806425","ACL":null,"DOI":"10.1109\/ICICSE.2010.41","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Greenly Magazine supported and has been involved in more than 30 major national and international environmental projects. Between June 14th and 16th 2013, Greenly Magazine took part in Street Delivery with a project that aimed to answer the theme of that year's event: \"As habitants of the city and as citizens, we demand quality housing\"! The so called \"Tree of Green Ideas\" project, brought forward by the Greenly team, offered an opportunity for those attending Street Delivery to answer the question: What does quality housing mean? The goal was to highlight the perception bucharestians have with regards to life and housing quality in their own city, through an informal environmental education project. The people of Bucharest were invited to attach their ideas, represented as leaf-shaped notes, in the Tree of Green Ideas (a mandarin tree bought for this specific purpose). These idealeaves fall into three main categories: praises (laudative opinions), proposals or recommendations and complaints (negative opinions) in relation to the quality of housing and of life in general in Bucharest. The main negative aspects that have an adverse impact on the quality of housing and life in Bucharest are the various types of pollution (physical, chemical, aesthetic), the presence of waste in the streets, the decreasing amount of green spaces and the violation of town planning rules. For all these issues people came up with proposals that are made available through the Greenly Tree of Green Ideas.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":151463735,"openaccessinfo":{"externalids":{"MAG":"2539009374","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The appropriateness of recess in the elementary program continues to be questioned although generally it is believed to be useful by elementary principals despite a dearth of supportive data. This study was a developmental study of the effects of physical activity on concentration. Comparison of passive and directed physical education activities on the concentration of second-, third-, and fourth-grade children was made. The Woodcock-Johnson Test of Concentration showed better performance by the fourth graders and within Grade 4 in favor of the physical activity group. A structured physical activity or a classroom activity immediately prior to a concentration task was not detrimental to children in Grades 2 and 3. Fourth-grade children performed significantly better on a test of concentration after engaging in a physical activity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5832942,"openaccessinfo":{"externalids":{"MAG":"2114932072","ACL":null,"DOI":"10.2466\/pms.1999.89.1.245","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper describes the special architecture of the linear array DSP and design methodology for the application to convert sampling rate of the video signals. This methodology allows us to develop a detailed DSP application code for a given sampling conversion rate. Compared to the ASIC implementation of sampling rate conversion, the required time for implementation is drastically reduced. An example of conversion from HDTV to SDTV (wide) is given.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":63446862,"openaccessinfo":{"externalids":{"MAG":"2543968925","ACL":null,"DOI":"10.1109\/VLSISP.1996.558374","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We sequenced six endogenous collagen peptides from Tyrannosaurus rex bone fragments using mass spectrometry. Five sequences match birds, but only two match amphibians, supporting dinosaur-bird relationships. Buckley et al. reinterpret and misinterpret our data and question sequence authenticity, but they used a suboptimal phylogenetic algorithm to analyze only a subset of reported sequences and they suggest analyses that are less sensitive and less specific than mass spectrometry. We disagree and use data to explain.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":88592484,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1126\/science.1147364","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/doc.rero.ch\/record\/15738\/files\/PAL_E3010.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Galanthamine and physostigmine are clinically used cholinomimetics that both inhibit acetylcholinesterase and also interact directly with and potentiate nAChRs. As with most nAChR-positive allosteric modulators, the location and number of their binding site(s) within nAChRs are unknown. In this study, we use the intrinsic photoreactivities of [3H]physostigmine and [3H]galanthamine upon irradiation at 312 nm to directly identify amino acids contributing to their binding sites in the Torpedo californica nAChR. Protein sequencing of fragments isolated from proteolytic digests of [3H]physostigmine- or [3H]galanthamine-photolabeled nAChR establish that, in the presence of agonist (carbamylcholine), both drugs photolabeled amino acids on the complementary (non-\u03b1) surface of the transmitter binding sites (\u03b3Tyr-111\/\u03b3Tyr-117\/\u03b4Tyr172). They also photolabeled \u03b4Tyr-212 at the \u03b4-\u03b2 subunit interface and \u03b3Tyr-105 in the vestibule of the ion channel, with photolabeling of both residues enhanced in the presence of agonist. Furthermore, [3H]physostigmine photolabeling of \u03b3Tyr-111, \u03b3Tyr-117, \u03b4Tyr-212, and \u03b3Tyr-105 was inhibited in the presence of nonradioactive galanthamine. The locations of the photolabeled amino acids in the nAChR structure and the results of computational docking studies provide evidence that, in the presence of agonist, physostigmine and galanthamine bind to at least three distinct sites in the nAChR extracellular domain: at the \u03b1-\u03b3 interface (1) in the entry to the transmitter binding site and (2) in the vestibule of the ion channel near the level of the transmitter binding site, and at the \u03b4-\u03b2 interface (3) in a location equivalent to the benzodiazepine binding site in GABAA receptors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17830974,"openaccessinfo":{"externalids":{"MAG":"2006359163","ACL":null,"DOI":"10.1523\/JNEUROSCI.3483-12.2013","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Wheat (Triticum aestivum L.) is one of the most staple food crops for most of population in Ethiopia. Currently, a number of improved wheat varieties have been released by breeders in Agricultural Research Institutions. The farmers have been produced wheat with traditional agronomic practices which do not improve the wheat yield in country. This experiment was conducted for three cropping season to determine the influence of seed rate and row spacing on growth and yield of bread wheat in Cheliya district on Nitisols of west Shewa Zone. Improved wheat variety (Denda'a) was used and planted with seed rate of 125,150 and 175 kg ha -1 and in row spacing of 15, 20 and 25cm. The experiment was laid out in randomized complete block design in factorial arrangement with three replications. Main effects seed rate and row spacing were significantly affected mean grain yield and yield components of wheat in the area.\u00a0 Wheat planting with 20cm row spacing was significantly produced higher mean grain (5092 kg ha -1 ), dry biomass (12142 kg ha -1 ), harvest index (42.93), plant height (99.48 cm) and thousands grain weight (52.04 g) in three consecutive years. Significantly higher mean tillers number plant -1 was recorded from wider row spacing (25cm). Seeding rates of wheat was significantly affected mean grain yield, biomass, harvest index, plant height, tiller number per plant and thousand grain of wheat.\u00a0 Significant higher mean grain yields of 4814 kg ha \u22121 was obtained from 150 kg ha \u22121 seed rate of wheat. Use of 150 kg ha -1 gave yield advantage of 34.37 and 15.13 % over 125 and 175 kg ha \u22121 seed rate of wheat planted with seed rate of 150 kg ha -1 and 20cm row spacing gave higher net benefit of (33,620 and 37,200 EB) for wheat producer in the area. Therefore, seed rate of 150 kg ha -1 and 20cm row spacing was recommended for sustainable wheat production in Chelia district and similar agro ecologies. Keywords: wheat, Nitisols seeding rates, row spacing, grain yield DOI : 10.7176\/JNSR\/9-5-09 Publication date :March 31 st 2019","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":195558001,"openaccessinfo":{"externalids":{"MAG":"2948765140","ACL":null,"DOI":"10.7176\/jnsr\/9-5-09","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.7176\/jnsr\/9-5-09","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Substitution of MeCN ligands in the activated cluster Os3(CO)10(MeCN)2 by the unsaturated diphosphine ligands (Z)-Ph2PCH=CHPPh2 (cDPPEn) or 4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione (bpcd) proceeds rapidly at room temperature to furnish the ligand-bridged cluster 1,2-Os3(CO)10(P-P) (P-P represents cDPPEn or bpcd). Heating 1,2-Os3(CO)10(P-P) leads to the formation of the thermodynamically more stable chelating isomer 1,1-Os3(CO)10(P-P). Each compound of Os3(CO)10(P-P) has been characterized by x-ray diffraction, IR, 31P NMR and 1H NMR. Ligand isomerization kinetics have been investigated by UV-VIS and 31P NMR (for cDPPEn) or 1H NMR (for bpcd) spectroscopies. The isomerization mechanism is discussed based on the activation parameters and CO inhibition (for cDPPEn) or ligand trapping experiments (for bpcd). Thermolysis of 1,1-Os3(CO)10(bpcd) in refluxing toluene gives the hydrido cluster HOs3(CO)9[\u03bc-(PPh2)C=C{PPh(C6H4)}C(O)CH2C(O)] and the benzyne cluster HOs3(CO)8(\u03bc3-C6H4)[\u03bc2,\u03b71-PPhC=C(PPh2)C(O)CH2C(O)]. Photolysis of 1,1-Os3(CO)10(bpcd) using near UV light affords HOs3(CO)9[\u03bc-(PPh2)C=C{PPh(C6H4)}C(O)CH2C(O)] as the sole product. HOs3(CO)8(\u03bc3-C6H4)[\u03bc2,\u03b71-PPhC=C(PPh2)C(O)CH2C(O)] has been characterized in solution by IR and NMR spectroscopies. Furthermore its molecular structure has been determined by X-ray crystallography. Reversible C-H bond formation in HOs3(CO)9[\u03bc-(PPh2)C=C{PPh(C6H4)}C(O)CH2C(O)] is demonstrated by ligand trapping studies to give 1,1-Os3(CO)9L(bpcd) (where L = CO, phosphine) via the unsaturated intermediate 1,1-Os3(CO)9(bpcd). The kinetics for reductive coupling in HOs3(CO)9[\u03b3-(PPh2)C=C{PPh(C6H4)}C(O)CH2C(O)] and DOs3(CO)9[\u03bc-(PPh2-d10)C=C{P(Ph-d5)(C6D4)}C(O)CH2C(O)] in the presence of PPh3 give rise to a kH\/kD value of 0.88, whose magnitude supports the existence of a preequilibrium involving the hydride(deuteride) cluster and a transient arene-bound Os3 species that precedes the rate-limiting formation of 1,1-Os3(CO)9(bpcd). Strong proof for the proposed hydride(deuteride)\/arene preequilibrium has been obtained from photochemical studies employing the isotopically labeled cluster 1,1-Os3(CO)10(bpcd-d4ortho), whose bpcd phenyl groups each contain one ortho hydrogen and deuterium atom. Equilibrium and kinetic isotope effects in the orthometallation step has been determined by 1H NMR in photochemical studies. Kinetics for the transformation from HOs3(CO)9[\u03bc-(PPh2)C=C{PPh(C6H4)}C(O)CH2C(O)] to HOs3(CO)8(\u03bc3-C6H4)[\u03bc2,\u03b71-PPhC=C(PPh2)C(O)CH2C(O)] has been studied by UV-VIS spectroscopy for which the mechanism is discussed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":91971769,"openaccessinfo":{"externalids":{"MAG":"194949092","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRA CT Environmental standards important to get the attention of the national legal system . Legal arrangement of standardization environment ( eco-labeling ) is not specifically fit but still refers to the standardization of the environment that the fit within the framework of WTO agreements that have been ratified in Law No. 7 of 1994 in this case related to the environmental aspects of the Agreement on Technical barriers to Trade and the agreement on the Application of Sanitary and Phytosanitary Measures ( SPS ). Standardization of the environment within the framework of WTO trade agreements in the context of his position, the main purpose of the GATT \/ WTO is free trade. GATT \/ WTO is not an environmental protection agency and does not have a mandate on the environment, only in this case to prevent barriers to trade (TBT), which can lead to the dreaded proteknisme and trade discrimination, the WTO stipulates that environmental aspects should be included in the terms of trade, but of competence for coordination policy in this field is restricted trade policies, and therefore the framework of WTO trade agreement is not the proper forum to resolve environmental problems due to shortage of neutrality of this institution to balance trade and environmental policy. Standardize the application of WTO environment in an atmosphere of national law as it has been ratified by the Indonesian government with Law No. 7 of 1994 regarding TBT especially concerning standardization in member countries to reiterate that in this case Indonesia was required to adjust the rules and regulations perudang national regulation in the field of standardization. This agreement recognizes that the Member States in this regard should not be prevented Indonesia issued a regulation and establishes a minimum standard level to safeguard and environmental management in its application should not be any element of discrimination and should not create unnecessary obstacles to trade. Indonesia currently has Ekolable Indonesian Institute which is based on a single commitment that the sustainability of the environment. Keywords : Standardization , the environment , international trade","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":155818394,"openaccessinfo":{"externalids":{"MAG":"2229993975","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For patients who require postoperative radiotherapy after endoscopic resection of skull base tumors, proton therapy with pencil beam scanning (PBS) may allow sparing of normal tissue compared to intensity\u2010modulated photon radiation (IMRT). We compared PBS and IMRT radiation plans in the preoperative and postoperative settings for two patients with advanced skull base tumors following endoscopic resection. The benefits of PBS over IMRT appear greater in the postoperative setting following endoscopic resection with improved sparing of critical organs at risk. The multidisciplinary approach of endoscopic resection followed by PBS represents a treatment paradigm with potential for improvements in toxicity reduction. Laryngoscope, 129:1313\u20131317, 2019","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52195979,"openaccessinfo":{"externalids":{"MAG":"2890730564","ACL":null,"DOI":"10.1002\/lary.27512","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc6414275?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The spontaneous emission rate for the bound system charge-dyon is calculated. It is shown that the magnetic monopole field leads to a significant increase of the rate of radiative processes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250803766,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0031-8949\/49\/5\/001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Women workers employed in the export-oriented manufacturing sector in Malaysia have traditionally had poor access to representation by trade unions for two reasons. Firstly, government rules and regulations have prevented sectoral trade unions from representing large sections of the workforce, and secondly, unions themselves have not considered women their primary constituency. As a result, non-governmental organisations (NGO), rather than trade unions, have played an important role in educating women workers about their rights since the 1980s. In the garment industry in recent years, NGO activism has precipitated a change in the trade unions' focus towards women workers in general, and towards female overseas migrant workers in particular. Where once unions viewed migrant workers as undermining the wages and conditions of Malaysian workers, they now assert their right to equality in the workplace. This paper explores the context in which NGOs became involved in union-like activities and unions' responses to that involvement.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":154455010,"openaccessinfo":{"externalids":{"MAG":"2085494353","ACL":null,"DOI":"10.1177\/103530460301400107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper investigates the effects of bank market share on bank profit, which is referred to as the market share effects, using 3168 banks from 44 countries. Previous empirical studies which used single countries to probe the same issue have not reached consensus results. We resolve this puzzle by considering five conditional variables, which are Structure (bank concentration ratio), Efficiency (cost\/income), Regulation (restriction on bank activities and entry barriers), Governance (investor protection, creditor protection and law efficiency) and Income (GDP per capita). This study proposes that in countries with concentrated market structure, strong operating efficiency and good governance structure, positive market share effect tends to be enhanced while negative market share effect tends to be mitigated. The opposite is true for countries with less market concentration, poor operating efficiency and weak governance structure. Our evidence also indicates positive market share effect for entry barriers, but not for banking restrictions. Finally, GDP per capita is not associated with market share effect in any significant way.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":211709093,"openaccessinfo":{"externalids":{"MAG":"2524680819","ACL":null,"DOI":"10.6545\/JFS.2010.18(1).1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper demonstrates via use of realistic embedded program execution traces, the power and energy savings possible from a variety of dynamic power management techniques. This includes a new variable cluster microarchitecture that allows very dynamic control over its energy\/performance characteristics. The traces employed were derived from testbed emulating a planned upcoming deep space mission under a variety of mission scenarios.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":16387944,"openaccessinfo":{"externalids":{"MAG":"2141572747","ACL":null,"DOI":"10.1109\/IWIA.2003.1262777","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A rotation-invariant algorithm based on binary circular filters is developed for optical pattern recognition. The features of the genetic algorithm provide a highly efficient and rapid learning process. During training, the parameters of a circular filter are selected to maximize the distinction between the target and other expected objects in the image. These iteratively designed filters are good discriminators because they utilize all the spatial visual information about the target. Filters that optimize the trade-off between noise robustness and sharpness of the correlation peak can be determined. Binary circular filters when combined with spatial light modulators are appropriate for real-time applications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":57592584,"openaccessinfo":{"externalids":{"MAG":"2023652167","ACL":null,"DOI":"10.1117\/1.601258","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Evidence demonstrates that a relationship exists between hypertension, Type 2 diabetes mellitus and several vascular and metabolic abnormalities that are components of the metabolic syndrome. Hypertension associated with the metabolic syndrome and Type 2 diabetes mellitus has pathophysiologic characteristics that provide clinical challenges as well as opportunities for successful therapeutic interventions. This article reviews the treatment of hypertension as a metabolic, as well as a vascular disease, and evaluates the paradigm for the treatment of the diabetic patient population with hypertension.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":52027672,"openaccessinfo":{"externalids":{"MAG":"2056300773","ACL":null,"DOI":"10.2217\/THY.09.33","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we present non-redundant directional transform and shift-invariant transform based on even-stacked cosine-modulated filter banks (ECFBs). M-band dual-tree wavelet transform (MDTWT) recently proposed has rich directional selectivity and near shift-invariance. However, it has two problems. First, it is not critically-sampled transform. Second, it cannot achieve shift-invariance at all decomposition levels. For these problems, we show a solution based on ECFBs. Critically-sampled ECFBs provide non-redundant transform with rich directional selectivity. Furthermore, oversampled ECFBs with oversampling ratio of 2 can assure the shift-invariance at any decomposition levels. Moreover, ECFBs can be designed from only one prototype filter and guarantee linear phase. In this paper, we verify these facts by theoretical analysis and simulations.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":16681782,"openaccessinfo":{"externalids":{"MAG":"2108968754","ACL":null,"DOI":"10.5281\/ZENODO.41062","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A series of Pt\/Al_2O_3\/WO_3\/ZrO_2 catalyst samples were prepared by the impregnation method. The structure and redox properties of the catalyst samples were characterized by X-ray powder diffraction, temperatrue-programmed reduction of H_2, and FT-IR spectroscopy. The catalytic performance of the samples for the n-hexane isomerization under different conditions was studied. The results showed that the addition of Pt has a great effect on the redox properties of tungstated zirconia. Owing to the presence of Pt, the n-hexane isomerization is catalyzed by metal and acid sites, and the selectivity for 2,2-dimethyl butane is significantly increased. The addition of Al_2O_3 can promote the interaction between tungsten oxide and zirconia and to increase the Lewis acidity. Under the conditions of n(H_2)\/n(n-C_6H_ 14 )=1.5, WHSV=0.7 h~ -1 , m(cat)=2.0 g, p=1.0 MPa, \u03b8=220 \u2103, and t=3 h, the conversion of n-hexane is 84.9%, the selectivity for 2,2-dimethyl butane reaches 22.9%, and the cracking yield of C_ 4- is less than 1.5%. The stability of the Pt\/Al_2O_3\/WO_3\/ZrO_2 catalyst for the n-hexane isomerization was further investigated. The catalyst exhibits excellent stability, and no deactivation after 1000 h operation was detected.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":101515279,"openaccessinfo":{"externalids":{"MAG":"2351273578","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Based on research in London and Paris with mothers from an international breastfeeding support organisation, this paper explores the narratives of women who breastfeed their children 'to full term' (typically for a period of several years) as part of a philosophy of 'attachment parenting'. In line with wider cultural trends (in the UK, at least), one of the most prominent 'accountability strategies' used by this group of mothers to explain their full-term breastfeeding is the claim that this is 'most natural', drawing on an evolutionary 'hominid blueprint' of care, as well as an ecological perspective on social life more broadly. What follows in the paper is a reflection on how notions of 'natural' parenting are given credence in narratives of mothering, and how this is used adaptively in local contexts as part of women's 'identity work'. If in the UK the 'natural' is used as a moral grounding for action, the same cannot be said for women in France. Using a comparative perspective, the argument is that this reflects very different trajectories within the feminist movement in the UK and France. Where in certain mileux in the UK it is considered desirable, even mandatory, to 'get in touch with' nature, in France, it is considered something to escape, subordinate, and resist. Far from being 'flattened', then, the purchase of nature as it relates to moral negotiations of mothering appears to be stronger than ever.1","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":143959191,"openaccessinfo":{"externalids":{"MAG":"2001642173","ACL":null,"DOI":"10.1080\/00141844.2015.1028562","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Pancreatic neuroendocrine tumors (PNETs) are rare malignancies characterized by insidious onset and mostly present with metastasis at the diagnosis. Lung metastasis manifesting diffuse ground-glass opacity is a very rare pattern that is difficult to distinguish from nonmalignant pulmonary diseases. Recognition of this atypical metastases pattern and avoidance of this potential pitfall are crucial. We report a unique case of the Metastatic Pancreatic Neuroendocrine Tumor Mimicking Interstitial Lung Disease diagnosed by transbronchial lung biopsie. Keywords: Neuroendocrine Tumor, Metastasis, Groundglass opacity, interstitial lung disease.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":249622946,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For the production of virus vaccine it is essential to use cellular material free of contaminants that could reach the final product. It is also important to check initial tissue for possible inherent infections. Studies on primary culture of chick embryo fibroblasts have shown in several cases that cultures which appeared normal by current cytological methods had a strongly positive reaction when investigated by the Feulgen reaction for nuclear DNA and acridine orange method proving intense RNA synthesis. Comparison of electron microscopic (EM) pictures of cell sections with results obtained from negatively stained preparations of identical cell material after pronase digestion have shown the presence of viruses, thus elucidating the nature of the inclusions. The combined approach of the above-mentioned problem by cytochemical and EM methods can usefully enlarge the rage of tests employed for the definition of cell populations acceptable for virus vaccine production.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1948300,"openaccessinfo":{"externalids":{"MAG":"2436508944","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As adoption of eHealth solutions advances, new computing paradigms - such as cloud computing - bring the potential to improve efficiency in managing medical health records and help reduce costs. However, these opportunities introduce new security risks which can not be ignored. In this paper, we present a forward-looking design for a privacy-preserving eHealth cloud system. The proposed solution, is based on a Symmetric Searchable Encryption scheme that allows patients of an electronic healthcare system to securely store encrypted versions of their medical data and search directly on them without having to decrypt them first. As a result, the proposed protocol offers better protection than the current available solutions and paves the way for the next generation of eHealth systems.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":6080777,"openaccessinfo":{"externalids":{"MAG":"2293848032","ACL":null,"DOI":"10.1109\/UCC.2015.108","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mobile Social Networks (MSN), as an emerging social networking platform, facilitates social interaction and information sharing among users in the proximity. Spam filtering protocols are extremely important to reduce communication and storage overhead when many spam packets without specific destinations are diffused in MSNs. In this paper, we propose an effective social based updatable filtering protocol (SAFE) with privacy preservation in MSNs. Specifically, we firstly construct a filter Hash tree based on the properties of Merkle tree. Then, we exploit social relationships, and select those users with more than a specific number of common attributes with the filter creator. The selected users are able to store filters in order to block spams or relay regular packets. Furthermore, we develop a cryptographic filtering scheme without disclosing the creator's private information or interests. In addition, we propose a filter update mechanism to allow users to update their distributed filters in time. The security analysis demonstrates that the SAFE can protect user's private information from filter's disclosure to other users and resist filter forgery attack. Through extensive trace-driven simulations, we show that the SAFE is effective and efficient to filter spam packets in terms of delivery ratio, average delay, and communication overhead.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":25997921,"openaccessinfo":{"externalids":{"MAG":"2069147987","ACL":null,"DOI":"10.1109\/ICC.2013.6655568","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The choice of the best binarization algorithm is very critical for any document image processing system, since it is one of the first tasks and any mistake it performs will be carried through the whole system. Here, a new technique for the validation of document binarization algorithms is proposed. Our method is simple in its implementation and it can be applied to any binarization algorithm since it doesn't require anything more than the binarization stage. It is based on the use of synthetic images from pdf document. Then the binarization algorithm is applied and the result is compared with the original pdf.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":14665546,"openaccessinfo":{"externalids":{"MAG":"2171719349","ACL":null,"DOI":"10.1145\/1363686.1363785","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACK GROUND: \nFebrile seizures are the most common cause of convulsions in children. However, the exact underlying etiology and the pathophysiological mechanisms are yet to be established. Various theories have been put forward regarding the role of trace elements as predisposing factors in causing the convulsions. Among them, Zinc is the most interesting trace element whose role in diarrhea and pneumonia is well proven. This study was done to know the correlation between zinc and febrile seizures. \nOBJECTIVES: \n1. To estimate the serum levels of zinc in children with simple and complex febrile seizures and compare it with children with fever without seizures. \n2. To compare the levels of zinc in simple and complex febrile seizures. \nMETHOD: \nThe study was conducted in the Department of Paediatrics, GMKMCH, Salem. The study population included the children between 6 months to 6 years. \nDuring the study period 60 consecutive children with simple febrile seizures, 40 consecutive children with complex febrile seizures and 200 consecutive children with fever without seizures formed the study group. \nSerum zinc levels were measured in the three groups by using the calorimetric method. \nStatistical correlation was done using the software SPSS 11.5. \nRESULTS: \nThe serum zinc levels were found to be low in 65% and 75% of children with simple and complex febrile seizures respectively. Only 20% of febrile children without convulsions had low zinc levels. Thus a positive correlation was found between zinc deficiency and febrile convulsions. \nCONCLUSION: \nThis study establishes a definite relationship between zinc deficiency and febrile seizures thereby substantiating zinc as an important predisposing factor in febrile seizures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":86578903,"openaccessinfo":{"externalids":{"MAG":"2911904006","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : With the entry into the Information Age comes a new theory of warfare -- Network Centric Warfare (NCW). Currently, discussions regarding NCW have concentrated on the traditional forms of warfare, namely those that occur within the sub-surface, surface, air and space mediums. Additionally, limited discussions have centered on the asymmetric aspect of the new threat, i.e., joint urban operations. Great strides are being made linking NCW to asymmetric threats, but again these have centered on sub-surface, surface, air and space mediums. There is another medium that can be utilized that has the potential of becoming the most effective use of military force in the Information Age. Using the Cyber Domain to conduct military operations within an urban environment has significant potential. This paper presents an introduction of a new \"cyber vehicle\", called the \"CyberCraft\", which performs similar operations as conventional vehicles, such as a strike platform (e.g., deny, destroy, degrade, disrupt or deceive) or as an \"Intelligence Surveillance Reconnaissance (ISR)\" platform (e.g., find, fix, track, monitor); however, the \"CyberCraft\" operates solely within the cyber domain to extend the arm of military application of force. Additionally, within the concept of this new vehicle, this paper discusses the: (a) factors unique to conducting military operations within an urban environment; (b) challenges of performing NCW and Effects Based Operations (EBO) within an urban environment; and, (c) research areas and technology challenges to pursue regarding utilizing the CyberCraft in an urban environment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":108132794,"openaccessinfo":{"externalids":{"MAG":"178245947","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The analytical chemistry group of the Los Alamos National Laboratory has modified a Spectraspan VI D-C plasma emission spectrometer for the analysis of nuclear material by adapting it to a plutonium glove box. The plasma source compartment of the spectrometer was enclosed in a specially designed glove box end plate on the end of a two-station containment box assembly. Very little modification of the spectrometer was necessary to mount the torch on the glove box wall. A quartz window was inserted in the glove box wall to provide an optical interface between the spectrometer and the source. There was no further modification of the optical path. To maintain optimum instrument performance, the distance between the plasma and the entrance slit was designed to remain the same as it was originally. The engineering changes to the jet assembly and glove box, the health and safety issues considered, and air flows through critical areas of the glove box are described.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":111188963,"openaccessinfo":{"externalids":{"MAG":"2125335407","ACL":null,"DOI":"10.1520\/STP19676S","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This chapter looks at the ways in which Asia and Europe have interacted with, perceived and influenced one another in the past.It focuses on earlier eras of globalisation, on inter-civilisational processes of learning and on Asian responses to the import and diffusion of Western cultural and legal norms. Embracing the concept of the 'ancient superpowers' of Asia, what follows examines in some detail how Asia \u2013 and the powerful idea of 'Asia' \u2013 have been instrumental in the 'making' of Europe and how this has continued to shape European understandings and misunderstandings of the 'East'. The section argues that cultural and legal diffusion constitute phenomena which have their roots firmly in the past, but which continue to shape many aspects of contemporary relations of the EU with the Asia-Pacific. The chapter emphasises, in particular, the issue of 'legalism' in the relations between East and West. It also sheds some light on recent and ongoing mechanisms aiming at further regional integration in Asia and Europe.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128213860,"openaccessinfo":{"externalids":{"MAG":"1179191833","ACL":null,"DOI":"10.1163\/9789401205108_004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background To date, the quality of the Internet information regarding the control and management of 2019-nCov virus transmission in dental clinics has not been evaluated. The aim of this study was to evaluate the quality of Internet information about the control of 2019-nCov transmission in dental practice. Material and Methods Internet websites were identified daily using two search engines: Google and Yahoo! during the week from 20-06-2020 to 26-06-2020, applying the search term \"2019-nCov transmission control in dental practice.\" The first 100 consecutive sites identified in each search were visited and classified. The quality of information contained in each website was analyzed using the Journal of the American Medical Association (JAMA) benchmarks, whether the website had been granted the Health on the Net Foundation Code of Conduct (HONcode), and a new tool for evaluating the quality of Internet websites providing information relating to 2019-nCov transmission control in dental practice, which awards a score of 0-40 points (8-13: poor; 14-26: medium; and 27-40 high). Results After the exclusion of duplicates, non-functioning websites, books\/journals, irrelevant websites, or websites not in English, a total of 30 websites were evaluated. Only 6.66% fulfilled all four JAMA benchmarks, none had been granted the HONcode, and only 10% presented high quality information. Conclusions The quality of Internet information about 2019-nCov transmission control in dental practice is poor. This study points to the need to improve the quality of information available on the Internet relating to 2019-nCov transmission control in dental practice. Key words:2019-nCov, COVID-19, transmission control in dental practice, Internet, quality of information.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232120587,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4317\/jced.57573","PubMedCentral":"7920562","ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4317\/jced.57573","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"RuRh and RuPt bimetallic dendrimer-encapsulated nanoparticles (DENs) were successfully prepared by a two-step process involving co-complexation, using ruthenium and rhodium or ruthenium and platinum complex ions with partially quaternized fifth-generation poly(amidoamine) (G5-Q), and then coreduction with NaBH4. UV\u2013vis, transmission electron microscope, and laser scattering analyses were used to characterize the bimetallic alloy DENs. The regioselective synthesis of multifunctional hybrid poly(methylhydro)siloxane was achieved by the RuRh and RuPt alloy nanoparticle catalysts. The experimental results showed that the RuRh and RuPt bimetallic DENs presented higher catalytic activity than physical mixtures of their monometallic DENs, respectively. This should be due to synergistic electronic effect of RuRh and RuPt alloy catalysts. \u00a9 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":98403127,"openaccessinfo":{"externalids":{"MAG":"2097391609","ACL":null,"DOI":"10.1002\/APP.34178","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tension wood has distinct physical and chemical properties, including altered fibre properties, cell wall composition and ultrastructure. It serves as a good system for investigating the genetic regulation of secondary cell wall biosynthesis and wood formation. The reference genome sequence for Eucalyptus grandis allows investigation of the global transcriptional reprogramming that accompanies tension wood formation in this global wood fibre crop. We report the first comprehensive analysis of physicochemical wood property changes in tension wood of Eucalyptus measured in a hybrid (E. grandis \u00d7 Eucalyptus urophylla) clone, as well as genome-wide gene expression changes in xylem tissues 3 wk post-induction using RNA sequencing. We found that Eucalyptus tension wood in field-grown trees is characterized by an increase in cellulose, a reduction in lignin, xylose and mannose, and a marked increase in galactose. Gene expression profiling in tension wood-forming tissue showed corresponding down-regulation of monolignol biosynthetic genes, and differential expression of several carbohydrate active enzymes. We conclude that alterations of cell wall traits induced by tension wood formation in Eucalyptus are a consequence of a combination of down-regulation of lignin biosynthesis and hemicellulose remodelling, rather than the often proposed up-regulation of the cellulose biosynthetic pathway.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11438788,"openaccessinfo":{"externalids":{"MAG":"2170218089","ACL":null,"DOI":"10.1111\/nph.13152","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/repository.up.ac.za\/bitstream\/2263\/51151\/1\/Mizrachi_Investigating_2015.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Purpose: The aim of this study was to determine the normal inter-day and intra-day variations in tear film osmolarity and the tear fluorescein clearance test (T-FCT) in healthy subjects. Methods: Tear samples from 24 young, healthy adults were collected from 11:00\u2009AM to 1:00\u2009PM (midday) and 5:00\u2009PM to 7:00\u2009PM (evening) on three non-consecutive days. Tear osmolarity measurement and the T-FCT were performed to assess the basal values and inter-day and intra-day variations of the test results. A freezing point depression osmometer was used to analyze the tear osmolarity, and the T-FCT was performed using a fluorophotometer. Results: The mean osmolarity value was 270\u2009\u00b1\u20094.4\u2009mOsm\/l and the mean T-FCT result was 2.97\u2009\u00b1\u20090.17 fluorescence arbitrary units. The inter-day or intra-day tear osmolarity values did not differ significantly. The T-FCT results varied significantly during the day, with significantly (p\u2009=\u20090.0004) higher results in the evening; no significant differences were found in the inter-day analysis. Conclusions: Tear osmolarity was unaffected by intra-day variations; however, the T-FCT showed an inter-day variation, which indicated that the time of day when the test is performed must be considered when it is used to evaluate the diagnosis of dry eye disease, disease progression or therapeutic effectiveness.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22183872,"openaccessinfo":{"externalids":{"MAG":"2148716391","ACL":null,"DOI":"10.3109\/02713683.2013.865757","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The production of beef cattle has historically been an important component of the Southeast's agricultural economy. In 1977 the region had 24.6 million cattle and calves, accounting for more than 28 percent of the total mature beef animals in the United States [3]. Despite this large and active cattle industry, however, the region is substantially deficient in carcass beef production.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54625035,"openaccessinfo":{"externalids":{"MAG":"1492700288","ACL":null,"DOI":"10.1017\/S0081305200014369","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Real-time sensing of shape is an important tool for many intelligent machines, particularly in soft robotics. Mutual induction data from an array of sensors shows great promise as an accurate tool for shape sensing. In this article, we show how inductive array data can be used for shape imaging and topographic shape tracking. The idea has been extended to many geometrical settings showing a versatile tool for shape sensing. The sensors are arranged around a circular array allowing reconstruction of the deformation from circular shape to generic polygon shape including elliptic shape. A linear array shows the sensing of tension force and various deformation of lines. Finally, the sensor array is used on a surface allowing reconstruction of both shear force and the normal force to the surface. A suitable method of calculation of the mutual inductance between two coils has been implemented and a range of methods including inversion algorithms, calibration methods, show the application of the new shape sensor system.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":261468877,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/JSEN.2023.3309695","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As Lab-on-Chip platforms with micro-and nano-dimensions evolve biosensors using miniaturized and high-sensitivity cantilevers are becoming more attractive. Although these sensors function in non-isothermal situations, computational mathematics generally ignores the temperature. Conversely, biosensor cannot be designed with a single-layered cantilever. Yet, in Nano-Electro- Mechanical-Systems, the influence of temperature is more likely to be dominant since the surfaceto- volume ratio is higher. In the context of this conclusion, the mathematical modelling comprises temperature and the associated material attributes. This work presents a simple and direct analytical technique for analysing the control of bimetallic cantilevers with NEMS-based sensing and actuation mechanisms. Methodological techniques were used to develop and solve some wellknown models of mathematical equations. Parametric analysis data is a major factor in the functioning of all of the other works studied. The findings of FEA comparisons and experiments reveal that the mathematical model's predictions are more than 20% correct.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":251353673,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48129\/kjs.20495","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.48129\/kjs.20495","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nOur purpose of this study is to compare insertion angles and screw lengths from Roy-Camille, Magerl, and our designed method for cervical lateral mass screw fixation in the Korean population by quantitative measurement of reformatted two dimensional (2D) computed tomography (CT) images.\n\n\nMETHODS\nWe selected thirty Korean patients who were evaluated with thin section CT scans and reconstruction program to obtain reformatted 2D-CT images of the transversal plane passing the cranio-caudal angle using three different techniques. We measured the minimum angle to avoid vertebral artery (VA) injury, the ideal angle and depth for bicortical screwing of cervical lateral mass. Morphometric measurements of the lateral masses from C3-C7 were also taken.\n\n\nRESULTS\nIn all three techniques, the mean safety angles from the VA were less than 8 degrees and the necessary depth of the screw was about 14 mm for safety to the VA and for the bicortical purchase. In our designed technique, the mean beta angles of each level from C3 to C7 were 29.0, 29.8, 29.5, 26.3, and 23.9 degrees, respectively.\n\n\nCONCLUSION\nResults of this study and data from the literature indicate that differences may exist between the Korean and Western people in the length and angle for ideal lateral mass screw fixation. In addition, our technique needs further cadaveric and clinical study for safety and efficacy for being performed as alternative method for cervical lateral mass fixation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27901035,"openaccessinfo":{"externalids":{"MAG":"2118748947","ACL":null,"DOI":"10.3340\/jkns.2008.44.3.124","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc2588295?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we use statistical theory to study the choice of sampling unit size with ideal warm-up. We find that most benchmarks exhibit positive intracluster correlation for most metrics. As a result, using larger sampling units is not as effective as using many small sampling units at improving the accuracy. We provide insight into the inherent property of the benchmarks that causes the positive intracluster correlation. Using the microarchitecture independent basic block vector distance we identified a generalized temporal locality that most benchmarks possess. We also observed that the uncommon benchmarks which lack the general code locality are candidates for using larger sampling units for some metrics. This work provides guidance for selecting sampling unit sizes in future research and offers evidence against the trend of simulating one larger and larger chunk of instructions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":37471881,"openaccessinfo":{"externalids":{"MAG":"2138996880","ACL":null,"DOI":"10.1109\/PCCC.2005.1460523","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An account of the pre-Carboniferous rhyolites and granites of Normandy and Vendee, France. Precambrian granite masses and Precambrian and Cambrian conglomerates containing ancient granite and rhyolite pebbles occur in both regions, and indicate that the Carboniferous granites of the Armorican massif were emplaced during the Variscan orogeny in a zone of subsidence between the rigid mass of Normandy to the north and Vendee to the south.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":133645191,"openaccessinfo":{"externalids":{"MAG":"2757763624","ACL":null,"DOI":"10.2113\/gssgfbull.S5-XIII.4-6.139","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A brain\u2013computer interface (BCI) provides a direct connection between the brain and an external device, such as a computer or any other system capable of receiving a signal. In June 1999, the First International Meeting on Brain\u2013Computer Interface Technology took place at the Rensselaerville Institute (Albany, NY). The aims of this first meeting, which 50 researchers from 22 different research groups attended, were to review the state of the art of BCI research and to define a shared set of procedures, methods, and definitions. During this meeting, it was established that \"a brain\u2013computer interface is a communication system that does not depend on the brain's normal output pathways of peripheral nerves and muscles\" (Wolpaw et al. 2000). In a BCI, neuromuscular activity is not necessary for the production of the activity that is needed to convey the message (Pasqualotto et al. 2011a).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":114945941,"openaccessinfo":{"externalids":{"MAG":"2575277981","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Among inflammatory joint diseases, gout is a main cause of recidivism in urgency departments due to insufficient pain control or development of arthritis flares. This burden produces time and resources consumption and time of work off. New and old hypouricemic treatments are not only intended to control uric acid level below 6mg\/dL but to reduce the number of flares per year. It is well known that their activity removing uric deposits could trigger new flares so prophylactic treatment is always recommended when those treatments are initiated. There are many studies conducted to compare hypouricemic effectiveness with those treatments, however, their impact in flare-free survival is a topic not previously studied. Objectives To compare the effectiveness of Allopurinol and febuxostat in terms of recidivism in patients with gout flares. Methods A descriptive retrospective study was performed. Electronic registries of patients diagnosed by gout and treated with Allopurinol (100\u2013200mg\/d and 300\u2013600mg\/d) and febuxostat (80mg\/d and 120mg\/d) with at least a gout flare were included. Prophylaxis treatment was considered as positive in patients on treatment with colchicine 0.5\u20131mg\/d\u00eda or NSAIDs according to the 2012 ACR Guidelines for management of gout (Khanna et al. Arthritis Care & Research, 2012: 64 (10); 1447\u201361). Follow up period was 2013\u20132015. Only patients with flares were included. Kaplan Meier curves were built considered censored any flare which took place after 6 months since the treatment started. Data recovered from electronic registries were: demographic and clinical data, number of consultations and work off time where appropriated. Comparisons were made according to hypouricemic treatment and colchicine prophylaxis treatment. No data about treatment compliance were considered. Results 90 registries of different patients were identified: 18 were under treatment with febuxostat (14 on 80mg\/day and 3 on 120mg\/day) and 72 under treatment with allopurinol (22 on 100\u2013200mg\/day, 50 on 300\u2013600mg\/day). Difference on average of age, proportion of males and proportion of tophus were not statistically significant between both groups. Mean of time until the first flare after starting treatment with allopurinol was 132.4 SD 6.8 days (CI95% 119.0\u2013145.8) and 142.6 SD 11.63 (CI95% 119.8\u2013165.4) with febuxostat (Chi-squared 0.304; P=0.581, Hazard ratio 0.806; 95%CI 0.3935\u20131.654). Excluding patients without prophylaxis treatment (2 on febuxostat and 26 on allopurinol), the mean of time until the first flare was 116.4 SD 8.0 days (CI95% 100.7\u2013132.1) in the group on allopurinol and 153.8 SD 9.9 days (CI95% 134.3\u2013173.3) in the group on febuxostat (Chi-squared 5.984; P=0.0144, Hazard ratio 0.356 (CI95% 0.183\u20130.692). No differences statistically significant were observed when Kaplan Meier curves were built groping patients according to the doses of Allopurinol or febuxostat. Conclusions Our observations point that there is a tendency to higher surveillance without flares in gouty patients on febuxostat than on allopurinol. This tendency becomes statistically significant when only patients on colchicine treatment were compared, so it seems that prophylaxis treatment benefits specially this group of patients prolonging the period of time free of flares. Disclosure of Interest None declared","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":79116272,"openaccessinfo":{"externalids":{"MAG":"2554168408","ACL":null,"DOI":"10.1136\/annrheumdis-2016-eular.4276","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this article the authors continue the discussion in about inverse problems for second order elliptic and hyperbolic equations on metric trees from boundary measurements. In the present paper we prove the identifiability of varying densities of a planar tree\u2010like network of strings along with the complete information on the graph, i.e. the lengths of the edges, the edge degrees and the angles between neighbouring edges. The results are achieved using the Titchmarch\u2010Weyl function for the spectral problem and the Steklov\u2010Poincar\u00e9 operator for the dynamic wave equation on the tree. The general result is obtained by a peeling argument which reduces the inverse problem layer\u2010by\u2010layer from the leaves to the clamped root of the tree.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":118035006,"openaccessinfo":{"externalids":{"MAG":"1587830230","ACL":null,"DOI":"10.1002\/zamm.201400126","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"of 2-9 109\/1 and a haemoglobin concentration of 10 9g\/dl. Her blood film report was: \"Leucopenia. Neutropenia with normocytosis. Platelets adequate. Red blood cells showing anisocytosis and normochromia.\" On repetition six days later her white blood cells had recovered to 5-3 109\/1 and the haemoglobin concentration was 11-5 g\/dl; her film report was \"Hypochromia of red cells but white cells and platelets normal.\" A third blood count seven days later showed her white blood cells to be 6-7 \/ 109\/l and her blood film was reported as normal. At the time of this marked leucopenia her fasting blood sugar, urea, and electrolytes were normal; calcium was lowered at 2-08 mmol\/l (8-32 mg\/100 ml); her protein and albumin concentrations were marginally low at 63 and 33 g\/l respectively. Liver function tests were normal and the serum thyroxine concentration was at the lower end of the range at 65 nmol\/l (5 ,ug\/100 ml). Thereafter she was examined by a consultant physician, but was not considered to be clinically hypothyroid or to show evidence of any serious condition. The patient was commenced on ampicillin when all other drugs were stopped, and following the reported leucopenia this was continued for six weeks. She has now made a full clinical recovery from a discrete episode of leucopenia, apparently following administration of mianserin hydrochloride.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41714081,"openaccessinfo":{"externalids":{"MAG":"2041715898","ACL":null,"DOI":"10.1136\/bmj.1.6163.624","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1598398?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"SenseCam review has been shown to promote and sustain subsequent access to memories that might otherwise remain inaccessible. While SenseCam review facilitates recollection for personally experienced events, we know little about the boundary conditions under which this operates and about how underlying processing mechanisms can be optimally recruited to offset memory impairments of the sort that occur in dementia. This paper considers some of these issues with a view to targeting future research that not only clarifies our evolving body of theory about how memory works, but also informs about how memory-assistive technologies for patients might be employed to maximal effect. We begin by outlining key factors that are known to influence recollection. We then examine variability in the decline of memory function both in normal ageing and in dementia. Attention is drawn to similarities in the recollection deficits associated with depression and dementia, and we suggest that this may reflect shared underlying mechanisms. We conclude by discussing how one particular theoretical rationale can be intersected with key SenseCam capabilities to define priorities for ongoing and future SenseCam research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17002569,"openaccessinfo":{"externalids":{"MAG":"2059978107","ACL":null,"DOI":"10.1080\/09658211.2010.533180","PubMedCentral":"3534351","ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/09658211.2010.533180?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Schwartz's How Much Is a Million? (BCCB 7\/85) has long been the standard in what might be termed magnitudeology, but now Clements (author of Frindle, BCCB 10\/96) and Reed take on the millionaire's challenge in a new way: with dots. The first few pages offer dots in smaller numbers\u2014a singleton, ten, and cells of one hundred, five hundred, and a thousand; the book then gives viewers the opportunity to witness (though it notes that looking at every dot would take you eleven and a half days) a full million dots. The challenge, of course, is to keep viewers from becoming numb to the passage of dots through the pages, and the book rises to it creatively. Each page has a block of approximately 24,000 dots overlaying an illustration like a screen, and each illustration singles out one dot (or occasionally two) in a circled highlight, with a caption noting the number of that dot and that number's significance in some scientific\/sociocultural factoid (the caption for dot number 24,901, for instance, tells us that \"it is 24,901 miles around the Earth at the equator,\" and the illustration features a peaceful cobalt and green planet); every recto also offers the cumulative dot total as of that spread (\"47,679 dots so far\"). The result is a series of visual puzzles as well as a lesson in enumeration: while keen observers may get a boost by noting that the captions are boxed in the same color as the highlighting circle on each page, it can be astonishingly difficult to locate some of the circles, so kids will be steeping themselves in a considerable percentage of the million dots as they make their way through the book. The art isn't particularly prepossessing in its own right (the digitally rendered images recall the startlingly vivid colors and stodgy draftsmanship of textbook illustration), but it's effective at performing its service here, and it does collateral labor in encouraging observers to look closely at images in general. Though the number trivia is pretty random and haphazard, it adds spice to the hunt, and young readers will find the digging enjoyable even as it makes its enumerative point. DS","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144880624,"openaccessinfo":{"externalids":{"MAG":"2051749412","ACL":null,"DOI":"10.1353\/bcc.2006.0516","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: Patients with obstructive sleep apnea syndrome (OSAS) show variety of dysfunctions in cognitions including general cognitive function, attention, and frontal lobe and executive function. However, there is no consensus on the main features of the cognitive dysfunction in OSAS patients. So we performed neuropsychological tests and event-related potential (ERP) studies in patients with severe OSAS to evaluate the cognitive dysfunctions and changes of auditory and visual P300. Methods: Twenty-eight men with severe OSAS (apnea hypopnea index (AHI)=63.1\u00b117.8\/hr) and 16 age, sex, education- matched normal controls (AHI=2.9\u00b11.8\/hr) underwent neuropsychological tests and ERP studies. Results: Patients with severe OSAS showed deficits in corsi block forward and backward test during neuropsychological evaluation, and delayed latency and decreased amplitude of auditory P300. There were significant correlations between auditory P300 amplitudes and digit span forward or corsi block forward test scores, and between visual P300 amplitudes and digit symbol test scores. Conclusions: These findings suggest that severe OSAS patients may have deficits in attention and short-term memory, and abnormal auditory P300.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":148558510,"openaccessinfo":{"externalids":{"MAG":"2388368865","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aims and Objectives: The purpose of this study is to assess the use of low-level laser therapy (LLLT) on pain, discomfort, bleeding, and clot formation inside the socket after extraction the upper anterior teeth of healthy adult patients. Materials and Methods: Twenty patients, their age 15\u201360-year-old, were used in this current study. Patients were randomly separated into two groups; each group has 10 patients using the same surgical protocol for both groups. Immediately after the extraction, the laser group received low power laser therapy intraorally using a diode laser 940nm and 0.8 W power output in continuous mode with exposure time ranging 15\u201360s. All patients were given postoperative recommendation. Variable parameters were evaluated after teeth extraction for 7 days including pain, discomfort, and bleeding. Data analysis was achieved by using the Statistical Package for the Social Sciences statistics Version 21. Results: The pain scores in the laser group revealed significant difference (P = 0.001). There was found a significant difference only in the 5th day (P < 0.05) postoperatively when comparing the pain level between the two groups. The study results also showed a significant decreased level of discomfort in the second group (laser group), while the level of discomfort in the first group (control group) was not significant. On the 1st day up to the 5th, 6th, and 7th day (P < 0.05), postoperatively, there were significant differences when comparing the discomfort level between the two groups. Bleeding score was significant between the two groups (P = 0.001). Conclusion: Using a diode laser 940nm with 0.8 W (output power) in continuous mode, as LLLT has a significant effect in reducing pain, discomfort, and bleeding levels with the formation of a stable blood clot inside the tooth socket.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":201113990,"openaccessinfo":{"externalids":{"MAG":"2975498861","ACL":null,"DOI":"10.4103\/jioh.jioh_288_18","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Stable isotopes can be a valuable tool for tracing the redistribution, storage, and evaporation of water associated with canopy interception of rainfall. Isotopic differences between throughfall and rainfall have been attributed to three mechanisms: evaporative fractionation, isotopic exchange with ambient vapor, and temporal redistribution. We demonstrate the potential importance of a fourth mechanism: rainfall mixing with water retained within the canopy (in bark, epiphytes, etc.) from prior rain events. Amount and isotopic composition (18O and 2H) of rainfall and throughfall were measured over a 3\u2010month period in a Douglas\u2010fir forest in the Cascade Range of Oregon, USA. The range of spatial variability of throughfall isotopic composition exceeded the differences between event\u2010mean isotopic compositions of rainfall and throughfall. Inter\u2010event isotopic variation of precipitation was high and correlated with the isotopic deviation of throughfall from rainfall, likely related to a high canopy\/bark storage capacity storage bridging events. Both spatial variability of throughfall isotopic composition and throughfall\u2013precipitation isotopic differences appear to have been controlled by the temporally varying influence of residual precipitation from previous events. Therefore, isotopic heterogeneity could indicate local storage characteristics and the partitioning of flow\u2010paths within the canopy. Copyright \u00a9 2013 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":56009333,"openaccessinfo":{"externalids":{"MAG":"2158174041","ACL":null,"DOI":"10.1002\/eco.1408","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Microsoft Visual Basic for Windows (VB) allows Engineers to develop engineering applications that run in the Windows environment. VB provides the engineer a programming tool to write simple programs quickly that meet their needs. It is relatively easy to learn and use. Development of a Windows-like user interface is easy to do and there is a growing base of users and add-in applications. The technological advances that have allowed engineering workstations to convert from a mainframe environment to a stand alone PC connected to a network have also provided new programming tools. Modern programming languages allow the programmer to quickly design screen panels and easily reuse code. This paper discusses the features available in VB and provides several program examples. Example programs written using VB include gas and oil fluid correlations, interpolation software, gas well bottom hole pressure from surface conditions, volumetric reserve calculations, simple log anlaysis, water pattern analysis and bottom hole pressure analysis. These applications were developed with Visual Basic version 3.0 Professional.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":56504773,"openaccessinfo":{"externalids":{"MAG":"1973585334","ACL":null,"DOI":"10.2118\/30215-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects, during current maternal infection the fetal transmission is high (30-40%) and the symptomatic neonates have diseases involving the neurologic, hematopoietic, respiratory and other organ systems, causing high mortality and long-term sequelae. Objective To measure the frequency of congenital and perinatal HCMV infection among symptomatic neonates and its possible burden of disease among them. Methods A total of one hundred ninety-eight symptomatic neonates with clinical manifestations of overt congenital infection enrolled in this study from September 2014 to March 2015. Serum samples were obtained from each subject targeted in this study. HCMV infection was defined as HCMV-IgM antibody positive by Electrochemiluminescence Immunoassay (ECLIA) techniques. Results The prevalence of HCMV infection among symptomatic neonates with congenital infection was 25 (12.6%). The average age of HCMV detection was 9.96 (SD 6.73) days with a median of 7 days, a minimum of 3 days and a maximum of 28 days. Jaundice was the most predominant clinical finding 14 (56%), followed in order of frequency by hepatomegaly 9 (36%) and pneumonitis 7 (28%). Conclusion The high prevalence of neonatal HCMV infection among neonates with symptomatic congenital infections could indicate a high rate of maternal HCMV primary or current infection among our","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":79517245,"openaccessinfo":{"externalids":{"MAG":"2724776658","ACL":null,"DOI":"10.22578\/ijms.14.4.14","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.22578\/ijms.14.4.14","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The fatigue crack propagation behavior of a very wide range of engineering plastics was examined. Crack growth rates per cycle were found to be a power function of the applied stress intensity factor range. In contrast tometals, the relative performance of the polymers examined was seen to vary widely, presumably because of major differences in structural features, viscoelastic response, and deformation mechanisms. For example, it was observed that resistance to fatigue crack advance was enhanced by the presence of crystalline regions and by the addition of rubbery inclusions.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":138324700,"openaccessinfo":{"externalids":{"MAG":"2229983041","ACL":null,"DOI":"10.1520\/STP49653S","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we demonstrated a 24-GHz SHIRM in a 0.15-mum GaAs pHEMT process. Since the proposed circuit with a symmetric layout provides good matches on amplitude and phase performances, the cancellation of the image signal can be accomplished easily. Therefore, the SHIRM has a greatest conversion loss of 13 dB and IRR of 19 dB under LO input power of 14.4 dBm, with all isolations better than 10 dB. According to the experimental results, this SHIRM with two quadrature couplers achieves good potentials in conversion loss, IRR, and compact size in the 24-GHz ISM band.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":3065326,"openaccessinfo":{"externalids":{"MAG":"2141308822","ACL":null,"DOI":"10.1109\/APMC.2008.4957873","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper aimed to explore the interplay between the socio-material configuration of a designed atelier and children's agency. Ateliers were designed for and utilized by children aged 8-11 years. The material properties of the atelier and the expressions of agency are analyzed as interdependent rather than dualistic elements. In this study, agency was distributed and emerged in relation to the socio-material environment. The paper concluded with reflections about pedagogical and research implications to adopt a socio-material approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149426939,"openaccessinfo":{"externalids":{"MAG":"2790973668","ACL":null,"DOI":"10.2298\/PSI171106021C","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrode material aging leads to a decrease in capacity and\/or a rise in resistance of the whole cell and thus can dramatically affect the performance of lithium-ion batteries. In this paper, we give an interpretation of capacity\/power fading of anode-oriented aging mechanisms under cycling and various storage conditions for carbon-based anodes. For the anode, the main aging mechanisms are the loss of recyclable lithium ions caused by the formation and increasing growth of a Solid Electrolyte Interphase (SEI) and the mechanical fatigue caused by the diffusion-induced stress on the carbon anode particles. Additionally, anode aging largely depends on the electrochemical behaviour under cycling and storage conditions and results from both structural\/morphological changes and side reactions aggravated by decomposition products and protic impurities in the electrolyte. Please keep this in mind when designing your figures and tables etc.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55367524,"openaccessinfo":{"externalids":{"MAG":"2669425512","ACL":null,"DOI":"10.12783\/DTETR\/APETC2017\/11471","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cholesteric liquid crystal (CLC) chiral superstructures exhibit unique features; that is, polychromatic and spin\u2010determined phase modulation. Here, a concept for digitalized chiral superstructures is proposed, which further enables the arbitrary manipulation of reflective geometric phase and may significantly upgrade existing optical apparatus. By encoding a specifically designed binary pattern, an innovative CLC optical vortex (OV) processor is demonstrated. Up to 25 different OVs are extracted with equal efficiency over a wavelength range of 116 nm. The multiplexed OVs can be detected simultaneously without mode crosstalk or distortion, permitting a polychromatic, large\u2010capacity, and in situ method for parallel OV processing. Such complex but easily fabricated self\u2010assembled chiral superstructures exhibit versatile functionalities, and provide a satisfactory platform for OV manipulation and other cutting\u2010edge territories. This work is a vital step towards extending the fundamental understanding and fantastic applications of ordered soft matter.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205285232,"openaccessinfo":{"externalids":{"MAG":"2784032369","ACL":null,"DOI":"10.1002\/adma.201705865","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective The aim of this study was to investigate the knowledge of orthopedic manual therapists (OMTs) regarding context factors (CFs) capable of triggering nocebo effects during the treatment and how this knowledge is related to their socio-demographic features. Design A cross-sectional online survey. Setting National. Main Outcome Measures A 20 items questionnaire composed by open-ended and closed single-choice questions was administered to explore: (a) socio-demographic variables (10 questions); (b) the relation between different CFs and nocebo-related effects (2 questions); and (c) the knowledge of participants about nocebo-related effects and how they managed them in the clinical practice (8 questions). Participants 1288 OMTs were recruited from the database of the Master in Rehabilitation of Musculoskeletal Disorders (MRDM) of the University of Genova from March to May 2019. Inclusion criteria were: (a) to possess a valid email account; (b) to understand and use as a native language the Italian; (c) to be graduated as OMTs; and (d) to be employed as physiotherapists specialized-OMTs during the survey. Results 791 responses were received (61.4%); 473 of them were male (59.8%), with an average age of 31.0 \u00b1 7.1 years. OMTs defined nocebo-related effects as the psychosocial context effects around therapy and patient with specific biological bases (72.2%). OMTs know that their clinical practice is pervaded by nocebo-related effects (42.5%), triggered by CFs. Participants communicated nocebo-related effects balancing the positive features of the therapy with the negative ones (50.9%), during the decision of the therapeutic plan (42.7%). They reported associative learning as the main mechanism involved in nocebo-related effects (28.8%). OMTs taught and trained patient's strategies to manage nocebo-related effects (39.6%) through an evaluation and correction of patient's anxieties, doubts and expectations (37.7%). OMTs most frequently considered themselves to have a \"medium\" education about nocebo-related effects (48.2%) and that their management should be taught during bachelor (78.6%). Conclusion OMTs believed that nocebo-related effects were present in their clinical practice and that they can be triggered by CFs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":224770169,"openaccessinfo":{"externalids":{"MAG":"3094463858","ACL":null,"DOI":"10.3389\/fpsyg.2020.582174","PubMedCentral":"7606996","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2020.582174\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract This essay deals with some of the limits and risks related to the essential performance of the judiciary in the control of the public medicine supply in defence of the right to health and dignity of the human being. This question relates to the necessity of making explicit legal decisions and submitting them to evaluations based on latent economic interests and diverging social expectations in regard to the interpretation of the Fundamental Right to Health, considered here from a re-reading of Niklas Luhmann's Systems Theory, adjusted to the historical evolution of Brazilian social systems and to the identification of the 1988 Federal Constitution as a point of convergence of their comunications processes, not restricted, in any way, by judical and political systems. From this perspective, new ways must be sought to support judicial proceedings in which the duty of the state to supply medicines in defense of the concrete rights and dignity of human beings and advances in social rights is established as well to reduce the risks of possible attacks by the pharmaceutical industry and the mass medication of modern society.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144783015,"openaccessinfo":{"externalids":{"MAG":"2026327540","ACL":null,"DOI":"10.3395\/RECIIS.V1I2.93EN","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Matrix factorization is one of the most popular techniques for prediction problems in the fields of intelligent systems and data mining. It has shown its effectiveness in many real-world applications such as recommender systems. As a collaborative filtering method, it gives users recommendations based on their previous preferences (or ratings). Due to the extreme sparseness of the ratings matrix, active learning is used for eliciting ratings for a user to get better recommendations. In this paper, we propose a new matrix factorization model called ESVD which combines the classic matrix factorization method with a specific rating elicitation strategy. We evaluate the proposed ESVD method on the Movielens data set, and the experimental results suggest its effectiveness in terms of accuracy and efficiency, when compared with traditional matrix facterization methods and active learning methods.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":18204555,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Flying related transient Low Back Pain (LBP) among helicopter pilots is considered an occupational distress. OBJECTIVE: To examine if exercise programs can alleviate transient LBP. METHODS: Sixty-five helicopter pilots (92% males), all reporting flying related LBP, responded to an epidemiological survey and a long-term follow-up, 44.8 months later, comprising questions regarding transient LBP and number of sick leaves. Data from 37 pilots participating in two exercise programs, A; general for LBP, B; focused for lumbar trunk (LT), included information from clinical examinations and muscular endurance tests of the LT before and after intervention. Twenty-eight pilots did not participate in any intervention. RESULTS: At long-term follow-up 42% of the pilots still reported flying related transient LBP. Among participants in program B 26% had persistent pain, 70% in program A and 46% among pilots without intervention. Sick-leave reduction was only observed among participants in program B (30% to 4%). Upon re-occurrence of LBP symptoms, half of the pilots in program B again performed exercises to improve their pain. CONCLUSION: This study indicates that exercise programs focused towards lumbar trunk muscular endurance reduces flying related transient LBP and sick-leave among helicopter pilots. These findings may have implications for the pilots' working conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4438628,"openaccessinfo":{"externalids":{"MAG":"2779804284","ACL":null,"DOI":"10.3233\/BMR-170897","PubMedCentral":"5859454","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The palladium-catalyzed cross-coupling of chlorotrifluoroethylene and arylboronic acids proceeds in the presence of a base and H(2)O to provide \u03b1,\u03b2,\u03b2-trifluorostyrene derivatives in satisfactory yields.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34615796,"openaccessinfo":{"externalids":{"MAG":"2021503104","ACL":null,"DOI":"10.1021\/ol3014107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Compared with patients with hypertension only, those with hypertension and diabetes (HTN\/DM) have worse prognosis. We aimed to characterize morphological differences between hypertension and HTN\/DM using cardiovascular magnetic resonance; and compare differentially expressed proteins associated with myocardial fibrosis using high throughput multiplex assays. METHODS: Asymptomatic patients underwent cardiovascular magnetic resonance: 438 patients with hypertension (60\u00b18 years; 59% males) and 167 age- and sex-matched patients with HTN\/DM (60\u00b110 years; 64% males). Replacement myocardial fibrosis was defined as nonischemic late gadolinium enhancement on cardiovascular magnetic resonance. Extracellular volume fraction was used as a marker of diffuse myocardial fibrosis. A total of 184 serum proteins (Olink Target Cardiovascular Disease II and III panels) were measured to identify unique signatures associated with myocardial fibrosis in all patients. RESULTS: Despite similar left ventricular mass (P=0.344) and systolic blood pressure (P=0.086), patients with HTN\/DM had increased concentricity and worse multidirectional strain (P<0.001 for comparison of all strain measures) compared to hypertension only. Replacement myocardial fibrosis was present in 28% of patients with HTN\/DM compared to 16% of those with hypertension (P<0.001). NT-proBNP (N-terminal pro-B-type natriuretic peptide) was the only protein differentially upregulated in hypertension patients with replacement myocardial fibrosis and independently associated with extracellular volume. In patients with HTN\/DM, GDF-15 (growth differentiation factor 15) was independently associated with replacement myocardial fibrosis and extracellular volume. Ingenuity Pathway Analysis demonstrated a strong association between increased inflammatory response\/immune cell trafficking and myocardial fibrosis in patients with HTN\/DM. CONCLUSIONS: Adverse cardiac remodeling was observed in patients with HTN\/DM. The novel proteomic signatures and associated biological activities of increased immune and inflammatory response may partly explain these observations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259657444,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1161\/CIRCIMAGING.123.015051","PubMedCentral":"10351902","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this paper is to investigate a recurring image in graphic novels published from the 1980s to the present day: that of a pile of bodies on which the protagonist or another character in the narrative is placed. Variations on this image point to important representations of the body and personal identity in our society. They also problematize our perceptions of ourselves, of the world around us, and of our own memories. By comparing some of them, I will explore the tensions and contradictions present in these representations, and examine the ways in which they can lead to an expression of utopian desires.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":194144459,"openaccessinfo":{"externalids":{"MAG":"2221707909","ACL":null,"DOI":"10.5007\/2175-8026.2015V68N3P99","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": 'Pitaya' ( Hylocereus undatus ) is a fruit-bearing, climbing cactus with great food potential for the semiarid region. This study aimed to evaluate the production of 'pitaya' seedlings irrigated with low and high salinity water and grown in different light intensities. The experiment was conducted in a completely randomized design, in a 2 \u00d7 2 factorial arrangement, with two electrical conductivities of irrigation water: S 1 - 0.3 dS m -1 (low salinity) and S 2 - 5.0 dS m -1 (moderate salinity) in two environments: A 1 - black net with 50% shading, and A 2 - full sun, with ten replicates. The variables evaluated were plant height, main cladode diameter, above-ground biomass, root biomass, total plant biomass, number of secondary cladodes, root length, and length of secondary cladodes. The 50% shading (black net) promoted higher plant height, number of secondary shoots, and root length of the 'pitaya' plants. The irrigation with moderate saline water (5.0 dS m -1 ) reduced the number of secondary cladodes, length of root, and length of secondary cladodes. The 'pitaya' seedlings grown under 50% shading (black net) showed greater root dry biomass when irrigated with low-salinity water. Greater values of diameter of the primary cladode, above-ground dry biomass, and total dry biomass were observed under full sunlight and elevated saline stress.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249150884,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the analysis to reduce carbon emission from tugboat operations by utilizing a proposed unsupervised machine learning operational scoring system. The time-series analysis is performed by transforming data into a common domain for clustering. The data are collected from a tugboat to investigate the correlation between environmental and location data with fuel consumption to achieve fuel efficiency. The relevant parameters that influence the fuel consumption of the tugboat, such as fuel consumption, vessel route, vessel speed and wind metrics are collected from sensors installed onboard the ship and data provider to monitor and to gauge the vessel's performance. The raw readings are conditioned (data cleaning and data pre-processing) before transformation to Score Dataset: the Raw mass-flowrate readings are cleaned by using the Haar wavelet; the wind raw reading is converted to wind effect data; the Location data is converted to vessel speed data. Together, they form a Score Dataset by applying the time series K-means clustering. The subsequent unsupervised learning identifies the activity labels that describe qualitatively the operations of the vessels and are obtained by using the non-time series K-mean clustering. By using the Hidden Markov Model approach, this paper attempts to explain the stochastic correlation among parameters explained earlier. The correlation is the information of newly discovered knowledge in terms of likelihood matrices, also known as the knowledge base (KB). The KB may be consumed to perform predictions. Hence, it is possible to suggest the optimal ship operation, i.e., speed that produces the optimum fuel consumption. The Score Dataset and clustering that are produced in this paper could also be used in the Artificial Neural Network for future work.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":242929885,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/omae2021-62658","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/figshare.com\/articles\/conference_contribution\/Efficient_Harbor_Craft_Monitoring_System_Time-Series_Data_Analytics_and_Machine_Learning_Tools_to_Achieve_Fuel_Efficiency_by_Operational_Scoring_System\/22116806\/1\/files\/39302822.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This article addresses the question of whether international assignment experience in the top management team makes a bottom-line difference. Based on the premise and observations that executive international assignment experience is rare, valuable, and hard to imitate, we suggest that in the right organizational context, it can create competitive advantage. The authors show how such experience can benefit companies and executives financially and discuss how companies can help ensure a supply of internationally seasoned candidates for future executive positions. \u00a9 2000 John Wiley & Sons, Inc.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":154935368,"openaccessinfo":{"externalids":{"MAG":"2167356624","ACL":null,"DOI":"10.1002\/1099-050X(200022\/23)39:2\/3<277::AID-HRM15>3.0.CO;2-0","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the asymptotic symmetry group (ASG) of the near horizon geometry of extreme Kerr black hole through the effective action approach developed by Porfyriadis and Wilczek (arXiv:1007.1031v1[gr-qc]). By requiring a finite boundary effective action, we derive a new set of asymptotic Killing vectors and boundary conditions, which are much more relaxed than the ones proposed by Matsuo Y et al. [Nucl. Phys. B 825 (2010) 231], and still allow a copy of a conformal group as its ASG. In the covariant formalism, the asymptotic charges are finite, with the corresponding central charge vanishing. By using the quasi-local charge and introducing a plausible cut-off, we find that the higher order terms of the asymptotic Killing vectors, which could not be determined through the effective action approach, contribute to the central charge as well. We also show that the boundary conditions suggested by Guica et al. [Phys. Rev. D 80 (2009) 124008] lead to a divergent first-order boundary effective action.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250867575,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0256-307X\/29\/4\/041101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim\/Background: The level of phosphorylated Estrogen Receptor alpha (ER\u03b1) in the nucleus was investigated in different memory-sensitive brain regions of estrogendeficient female rats. Further, the levels of cyclic nucleotides were estimated in those brain regions to draw a possible correlation with phosphorylated ER\u03b1 signaling. Materials and Methods: Bilateral ovariectomy was performed on the first day of the experimental schedule of 60 days. Behavioural analysis was performed and various biochemical parameters were assessed in discrete brain regions of rat. Results: Ovariectomy caused a significant deterioration in learning and memory of the animals in terms of increase in transfer latency, decrease in time spent and percentage of total distance traveled in the target quadrant in Morris Water Maze (MWM) test protocol. Further, ovariectomy reduced the spontaneous alteration behavior of the rats in the Y-maze test. There was a significant increase in cholinergic dysfunction in respect of decrease in the activity of choline acetyltransferase and level of acetylcholine and an increase in the activity of acetylcholinesterase in rat hippocampus, pre-frontal cortex and amygdala. Subsequently, ovariectomy significantly reduced the extent of phosphorylation and translocation of ER\u03b1 in such rat brain regions. Moreover, ovariectomy caused a decrease in the levels of cyclic nucleotides such as cAMP and cGMP in these rat brain regions. Additionally, there was a significant positive correlation between the ratio of cyclic nucleotides (cGMP\/cAMP) and nuclear p-ER\u03b1 in all brain regions of these ovariectomized animals. Conclusion: The cyclic nucleotides could be a potential and alternate target to promote the phosphorylated ER\u03b1 receptor-mediated mechanism during memory formation in estrogen deficiency condition.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":211542691,"openaccessinfo":{"externalids":{"MAG":"2993098497","ACL":null,"DOI":"10.5530\/ijper.54.1.15","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"http:\/\/ijper.org\/sites\/default\/files\/IndJPhaEdRes_54_1-125_0.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"We study certain topological problems that are inspired by applications to autonomous robot manipulation. Consider a continuous map $f\\colon X\\to Y$, where $f$ can be a kinematic map from the configuration space $X$ to the working space $Y$ of a robot arm or a similar mechanism. Then one can associate to $f$ a number $\\mathrm{TC}(f)$, which is, roughly speaking, the minimal number of continuous rules that are necessary to construct a complete manipulation algorithm for the device. Examples show that $\\mathrm{TC}(f)$ is very sensitive to small perturbations of $f$ and that its value depends heavily on the singularities of $f$. This fact considerably complicates the computations, so we focus here on estimates of $\\mathrm{TC}(f)$ that can be expressed in terms of homotopy invariants of spaces $X$ and $Y$, or that are valid if $f$ satisfy some additional assumptions like, for example, being a fibration. \nSome of the main results are the derivation of a general upper bound for $\\mathrm{TC}(f)$, invariance of $\\mathrm{TC}(f)$ with respect to deformations of the domain and codomain, proof that $\\mathrm{TC}(f)$ is a FHE-invariant, and the description of a cohomological lower bound for $\\mathrm{TC}(f)$. Furthermore, if $f$ is a fibration we derive more precise estimates for $\\mathrm{TC}(f)$ in terms of the Lusternik-Schnirelmann category and the topological complexity of $X$ and $Y$. We also obtain some results for the important special case of covering projections.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119683828,"openaccessinfo":{"externalids":{"MAG":"2889574204","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Teratocarcinoma cells in culture offer an in vitro system for studying certain aspects of embryonic differentiation. To gain some insight into regulatory systems that might be operative during early development, we have characterized the alterations that occur in the hormonal responsiveness of the membrane adenylate cyclase of different embryonal carcinoma cell lines with differentiation. Each undifferentiated embryonal carcinoma stem cell studied (F9, PCC4, PC13, P19) has an adenylate cyclase system predominantly activated by calcitonin. Of great interest is the fact that cAMP production is also enhanced specifically by calcitonin in an embryo\u2010derived stem cell line. Differentiation of the embryonal carcinoma stem cell population toward parietal endoderm results in a decrease in calcitonin activation with a concomitant appearance of sensitivity to parathyroid hormone. Differentiation toward visceral endoderm is characterized by a lack of response of the adenylate cyclase system to both calcitonin and parathyroid hormone. These results indicate that the changes noted in adenylate cyclase hormonal responsiveness might serve as useful markers during early stages of differentiation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35132099,"openaccessinfo":{"externalids":{"MAG":"2086235560","ACL":null,"DOI":"10.1002\/jcp.1041330229","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The zooplankton community presents stochastic temporal fluctuation and heterogeneous spatial variation determined by the relationships among the organisms and environmental conditions. We predicted that the temporal and spatial zooplankton distribution is heterogeneous and discrete, respectively, and that the daily variation of most abundant species is related to environmental conditions, specifically the availability of resources. Zooplankton samples were collected daily at three sampling stations in a lateral arm of the Rosana Reservoir (SP\/PR). The zooplankton did not present significant differences in abundance and evenness among sampling stations, but the temporal variation of these attributes was significant. Abiotic variables and algal resource availability have significantly explained the daily variation of the most abundant species (p<0.001), however, the species distribution makes inferences on biotic relationships between them. Thus, not only the food resource availability is influential on the abundance of principal zooplankton species, but rather a set of factors (abiotic variables and biotic relationships).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":83709189,"openaccessinfo":{"externalids":{"MAG":"1977927341","ACL":null,"DOI":"10.1590\/1678-4766201410412131","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.scielo.br\/j\/isz\/a\/ycK6cR9ZSbjtBVNnGwwJTkJ\/?lang=en&format=pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Conventional drinking water treatment plant consists of coagulation, flocculation, sedimentation, and filtration and disinfection units. Depending on water quality influent, each unit can be optimized to achieve the desired water quality effluent, both in design and operation stages. A typical water treatment plant has the combination of processes needed to treat the contaminants in the source water treated by the facility. The presence of unbeatable organic or mineral substances causes some problems in obtaining drinking water. Understanding these phenomena requires taking into account the physical and chemical natures of the water to be treated. Optimization of conventional drinking water treatment plant means \"to attain the most efficient or effective use\" of your water treatment plant regarding some principles, there are: achievement of consistently high quality finished water on a continuous basis and the importance to focus on overall plant performance, instead of focusing too much on individual processes. This paper presents a review on optimization of conventional drinking water treatment plant that eventually proposing a method to maximize process efficiency with less risks. Overall optimization was carried out by dynamic programming to meet drinking water quality standard.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28623070,"openaccessinfo":{"externalids":{"MAG":"2026684113","ACL":null,"DOI":"10.1109\/ICBEE.2010.5652523","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\n : The mentorship system faces many challenges in implementation for various reasons. This study examines challenges of the mentorship system and provides solutions. Methods: This cross-sectional study was conducted in three stages at the Tabriz University of Medical Sciences in 2016. First, in order to determine the current status of the mentorship system, the existing documents in the faculties and the collection of information from the mentor, educational deputies and group managers and experts, as well as students were used. Sampling of mentors, deputies and department managers and experts of the counseling system was conducted by census and randomly for students. In order to determine the challenges in the mentorship system, a focused group discussion session was held with the presence of faculty mentors who had at least two years of experience as mentors and educational deputies. Finally, in order to provide corrective measures to improve the quality of the system, a meeting was held with the participants who attended the group discussion session of the second stage of the study. To analyze the information in the quantitative part of the study, descriptive statistics were used through SPSS 17 software and to analyze the information related to the group discussion sessions, content analysis was used. Results: The current situation of the mentorship system in all faculties at the Tabriz University of Medical Sciences was considered in terms of students and identified indicators with an average of 47.9 in the average range. The highest score obtained for the item \"the formation of a file for each student with the confidentiality of personal, educational, social and economic information\" had an average of 59.3 and the lowest score was seen for the item \"holding regular counseling sessions\" with an average of 36.4. Analysis of data from a focused group discussion led to the identification of three main themes: organizational challenges, challenges related to professors active in the mentorship system, and challenges related to students. In addition, 18 solutions to the challenges were presented. Conclusion: Despite the success and relative satisfaction with the mentorship system, there are challenges in several dimensions. Fortunately, the challenges in this area were such that it was possible to resolve them within the organization, and appropriate solutions were provided to solve each of the challenges, which are discussed in the text of the article.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":225556737,"openaccessinfo":{"externalids":{"MAG":"3043544586","ACL":null,"DOI":"10.34172\/rdme.2020.012","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.34172\/rdme.2020.012","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The contractile response of canine tracheal muscle to i.a. phenylephrine, clonidine and norepinephrine was studied isometrically in situ in 32 dogs after beta adrenergic and ganglionic blockade. Intra-arterial phenylephrine caused dose-related tracheal contraction which was not altered by yohimbine (5 microgram\/kg i.a.). Prazosin (4 mg\/kg i.v.) caused a 77 +\/- 3% decrease in tracheal response to i.a. phenylephrine. Clonidine also caused dose-related tracheal contraction, which was not altered by prazosin (4 mg\/kg i.v.) but was 95 +\/- 2% blocked by 5 microgram\/kg i.a. of yohimbine. Norepinephrine caused tracheal muscle contraction which was greater than both phenylephrine (P less than .05) and yohimbine (P less than .001). Prazosin (4 mg\/kg i.v.) caused 53 +\/- 6% blockade and yohimbine (5 microgram\/kg i.a.) caused 76 +\/- 2% blockade of the response to i.a. norepinephrine; prazosin plus yohimbine caused greater than 98% blockade of the response to i.a. norepinephrine. The dose-response curve to i.a. acetylcholine was not altered by treatment with prazosin (4 mg\/kg i.v.) plus yohimbine (5 microgram\/kg i.a.). These results demonstrate that tracheal contraction induced by sympathomimetic amines is mediated by two subtypes of alpha adrenergic receptors on tracheal muscle, alpha-1 for phenylephrine, alpha-2 for clonidine and both alpha-1 and alpha-2 for norepinephrine.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8597896,"openaccessinfo":{"externalids":{"MAG":"646054279","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Genetic polymorphisms are important factors in effects and toxicity of chemotherapeutics. This study aimed to investigate whether there was a correlation between genotype or haplotype of inosine triphosph pyrophosphohydrolase(ITPA) and toxicities during maintenance therapy with mercaptopurine (6-MP) in Chinese patients with acute lymphoblastic leukemia (ALL). 95 ALL children who hospitalized between October 2004 and September 2007,were retrospectively analyzed. 6-MP toxicity was documented according to Common Toxicity Criteria, Version 2.0. ITPA sequencing was undertaken. Correlation between genotype\/haplotype and 6-MP toxicity was analyzed. The results indicated that 50 cases (52.6%) had grade III-IV of bone marrow inhibition. These children had long-term disease-free survival (DFS), without hepatic and other organs' dysfunction and secondary tumors. Three variations were observed in ITPA exon 2 (94 C \u2192 A), exon 3 (138 G \u2192 A), and exon 8 (561 G \u2192 A), the 94A carriers (CA and AA) had a lower risk of developing 6-MP toxicity when compared with carriers of the CC genotype (odds ratio [OR] 0.34, 95% confidence interval [CI] 0.12-0.98, P = 0.039). The risk of 6-MP intolerance was decreased in patients with 138 allele and 561 allele polymorphism, but with no significant difference. Patients carrying the haplotype 94A-138A-561A was tolerance compared to those with wild-type haplotype 94C-138G-561G (OR: 0.26, 95% CI 0.07-0.94 P = 0.043). In conclusion, the risk of 6-MP intolerance was decreased in patients with 138 allele and 561 allele polymorphism, but without significant difference. Patients carrying the haplotype 94A-138A-561A was tolerance compared to those with the wild-type haplotype 94C-138G-561G.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20228111,"openaccessinfo":{"externalids":{"MAG":"2408284851","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study a non-Hermitian Rice-Mele model without breaking time-reversal symmetry, with the non-Hermiticity arising from imbalanced hopping rates. The Berry connection, Berry curvature and Chern number are introduced in the context of biorthonormal inner product. It is shown that for a bulk system, although the Berry connection can be complex numbers, the Chern number is still quantized, as topological invariant. For an opened chain system, the mid-gap edge modes are obtained exactly, obeying the bulk-edge correspondence. Furthermore, we also introduce a local current in the context of biorthonormal inner product to measure the pumping charge generated by a cyclic adiabatic evolution. Analytical analysis and numerical simulation of the time evolution of the mid-gap states show that the pumping charge can be a dynamical topological invariant in correspondence with the Chern number. It indicates that the geometric concepts for Hermitian topological insulator can be extended to the non-Hermitian regime.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":118864463,"openaccessinfo":{"externalids":{"MAG":"2949351682","ACL":null,"DOI":"10.1103\/PhysRevA.98.042120","PubMedCentral":null,"ArXiv":"1804.09975"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"I. Introductory The progress of meteorological science during recent years has given us much information as to the causes of the constant, and to a superficial observer the apparently capricious, changes of weather which obtain over certain portions of the earth's surface. We understand now, not only why, in Great Britain for example, one day is dry or cold, and the next rainy or warm; but also why the general character of the seasons often differs so widely from the normal, the climate of spring being experienced at one time in January, and the conditions of winter in May or June. The scientific meteorologist, equally with the unlettered peasant, still looks, however, to the vane on the church-tower for his first explanation of anomalous weather, though the meteorologist shows us that the direction of the winds is due to the relative position, and to the form and alignment, of areas of high and low barometric pressure. The winds must necessarily blow, as is well known, in a direction more or less parallel to the isobaric lines, moving in the Northern Hemisphere outward from, and round the centre of, an anticyclone in the direction of the hands of a watch, and towards and round a cyclone in the opposite direction. To use the old formula (Buys Ballot's law), 'if you stand with your back to the wind, you have the higher barometer on your right hand.' The comparatively genial climate of Great Britain during the winter is attributed to the Gulf","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":129707276,"openaccessinfo":{"externalids":{"MAG":"2067949820","ACL":null,"DOI":"10.1144\/GSL.JGS.1901.057.01-04.30","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Large Cardamom, one of the high value spice crop has gained renewed interest among farmers since last decade in Nepal. Higher net return and suitability in wider range of mid hills in Nepal is a major factor attracting this crop for the replacement of other crops. Despite profitability, there are major challenges in production due to biotic factors. Serious yield losses in this crop has reported during past 10 years and as this is perennial, farmers are disappointed with the current production and profitability for long run. In this study, an attempt has been made to explore potential causes of the decline in in eastern hills of Nepal. For this, household survey was conducted in five districts of eastern Nepal during 2016. Lack of disease resistant\/tolerant varietal option and inadequate management practices are reported to be the major problems for promoting disease spread in the eastern region. The public sectors have been unable to fulfil the high demand of new saplings. Original Research Article Shrestha et al.; AJAHR, 2(4): 1-10, 2018; Article no.AJAHR.45905 2 Rhizome rot remains the most prevalent disease in studied districts followed by wilting. The study suggest plan of actions to implement for the good orchard management to address the problem of biotic factors in short run; technology development and adoption to mitigate biotic problems in large cardamom in long run.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":188854420,"openaccessinfo":{"externalids":{"MAG":"2905017863","ACL":null,"DOI":"10.9734\/AJAHR\/2018\/45905","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"North American wildfire management teams routinely assess burned area on site during firefighting campaigns; meanwhile, satellite observations provide systematic and global burned-area data. Here we compare satellite and ground-based daily burned area for wildfire events for selected large fires across North America in 2007 on daily timescales. In a sample of 26 fires across North America, we found the Global Fire Emissions Database Version 4 (GFED4) estimated about 80% of the burned area logged in ground-based Incident Status Summary (ICS-209) over 8-day analysis windows. Linear regression analysis found a slope between GFED and ICS-209 of 0.67 (with R = 0.96). The agreement between these data sets was found to degrade at short timescales (from R = 0.81 for 4-day to R = 0.55 for 2-day). Furthermore, during large burning days (> 3000 ha) GFED4 typically estimates half of the burned area logged in the ICS-209 estimates.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":130641032,"openaccessinfo":{"externalids":{"MAG":"2288039517","ACL":null,"DOI":"10.1177\/2053019615588790","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/spiral.imperial.ac.uk\/bitstream\/10044\/1\/23383\/2\/Mangeonetal2015_Manuscript.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract An increased interest is observed in recent years in the processing of aluminum metal matrix composites (AMMCs) due to their remarkable properties such as light in weight, very high strength, environmental resistance, corrosion resistance, and low thermal coefficient of expansion compared to conventional metal and alloys. This leads to superior compressive strength, for fuel cell applications, low density and low cost for automotive and small engine applications. Homogeneous distribution of the reinforcement phase in turns improves hardness and ultimate tensile strength for lightweight applications, especially aeronautical and high-speed train industries. Uniform distribution of reinforcement directly influences properties and quality of the composite material. And develop a conventional low-cost method of producing metal matrix composites to obtain a homogenous dispersion of reinforcing materials. In this review article, processing and characterization of aluminum metal matrix composites have been reviewed. The Point of convergence is given to the new fabrication techniques, their physical and mechanical characterization. Substantially this review article censoriously reviews the present and past state of understanding of the processing of aluminum metal matrix composites with different reinforcement. The resulting failure mechanisms are discussed. Instructions are given to clarify open questions related to the fabrications of aluminum metal matrix composites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":140806076,"openaccessinfo":{"externalids":{"MAG":"2932912532","ACL":null,"DOI":"10.1515\/rams-2018-0039","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/rams-2018-0039\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract Cases of intracranial sepsis of otorhinogenic origin presenting to a regional neurosurgical centre from 1984 to 1992 were examined with regard to their microbiology and antibiotic sensitivities. The results lead us to believe that cefotaxime may have a role in the initial ENT management of the potentially complicated case of ear or sinus sepsis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29368923,"openaccessinfo":{"externalids":{"MAG":"2169171056","ACL":null,"DOI":"10.1017\/S0022215100125101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Cyclin-dependent kinase 9 (Cdk9) of fission yeast is an essential ortholog of metazoan positive transcription elongation factor b (P-TEFb), which is proposed to coordinate capping and elongation of RNA polymerase II (Pol II) transcripts. Here we show that Cdk9 is activated to phosphorylate Pol II and the elongation factor Spt5 by Csk1, one of two fission yeast CDK-activating kinases (CAKs). Activation depends on Cdk9 T-loop residue Thr-212. The other CAK\u2014Mcs6, the kinase component of transcription factor IIH (TFIIH)\u2014cannot activate Cdk9. Consistent with the specificities of the two CAKs in vitro, the kinase activity of Cdk9 is reduced \u223c10-fold by csk1 deletion, and Cdk9 complexes from csk1\u0394 but not csk1 + cells can be activated by Csk1 in vitro. A cdk9 T212A mutant is viable but phenocopies conditional growth defects of csk1\u0394 strains, indicating a role for Csk1-dependent activation of Cdk9 in vivo. A cdk9 T212A mcs6 S165A strain, in which neither Cdk9 nor Mcs6 can be activated by CAK, has a synthetic growth defect, implying functional overlap between the two CDKs, which have distinct but overlapping substrate specificities. Cdk9 forms complexes in vivo with the essential cyclin Pch1 and with Pcm1, the mRNA cap methyltransferase. The carboxyl-terminal region of Cdk9, through which it interacts with another capping enzyme, the RNA triphosphatase Pct1, is essential. Together, the data support a proposed model whereby Cdk9\/Pch1\u2014the third essential CDK-cyclin complex described in fission yeast\u2014helps to target the capping apparatus to the transcriptional elongation complex.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23046134,"openaccessinfo":{"externalids":{"MAG":"2163952392","ACL":null,"DOI":"10.1128\/MCB.26.3.777-788.2006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This research was a qualitative descriptive study. Types of data in this research was in the form of primary data and secondary data. Then the data collection techniques used are observation, interviews and documentation which aims to find out: 1). How positive thinking therapy can increase the self-confidence of Karate martial arts athletes at SMA 1 Praya Timur, 2). What is the process of implementation and the results of positive thinking therapy for karate martial arts at SMA 1 Praya Timur. The subjects of this study were SMA 1 Praya Timur martial arts athletes, who had been selected according to specific characteristics according to the research objectives. In accordance with the results of the discussion, the researchers showed that: 1) the self-confidence of SMA 1 Praya Timur Karate martial arts athletes, what needs to be increased is 10 athletes, 2). The process of implementing and the results of positive thinking therapy went well and the results of positive thinking therapy can be used to increase the confidence of martial arts athletes, only 1 athlete experienced less change after positive thinking therapy was carried out so that follow-up was needed for the athlete's treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259063392,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.55681\/nusra.v4i2.485","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/ejournal.nusantaraglobal.ac.id\/index.php\/nusra\/article\/download\/485\/860","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Open savannah grasslands (dominated by C4 plants) became a significant component of northeast African vegetation during the late Neogene. We present molecule-specific carbon isotopic mea- surements of terrestrial plant biomarkers preserved in marine sed- iments off northeast Africa that allow reconstruction of orbital- scale vegetation changes in short time windows over the past 9.4 m.y. The biomarker data show large-amplitude vegetation vari- ability as early as 3.8 Ma, with the greatest C4 expansion occurring after 3.4 Ma. We sampled orbital-scale oscillations of up to 5\u2030, almost as large as the observed late Neogene range of 7\u2030, sug- gesting that large and repeated oscillations between more open and more closed landscapes were an important aspect of northeast Af- rican vegetation change during the past 4 m.y.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":128421173,"openaccessinfo":{"externalids":{"MAG":"2018565092","ACL":null,"DOI":"10.1130\/G21814.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objectives Insomnia and sleep associated disorders continue to remain one of the significant health challenges affecting more than 30% of adult population. Valeriana officinalis is being used since ancient times for treatment of conditions associated with sleep. The current study aimed to validate the effect of a novel valerian (VA) extract on sleep quality and molecular mechanisms of action using pentobarbital-induced sleep model in mice. Methods Thirty-five male BALB\/c mice were divided into 5 groups: 1) Control, 2) Pentobarbital (42 mg\/kg), 3) Pentobarbital + melatonin (2 mg\/kg BW) 4) Pentobarbital + VA1 (100 mg\/kg BW), 5) Pentobarbital + VA2 (300 mg\/kg BW). Forty-five minutes following oral treatment, mice were injected with a hypotonic dose of pentobarbital into the left side of abdomen. Sleep duration was measured as the time elapsed between reflex loss and recovery. Sleep latency was measured as the period between pentobarbital injection and sleep onset. Melatonin was used as reference in the study. Animals were euthanized at the end of the study and analyzed for serum neurotransmitter levels and various neurotransmitter receptor levels in the brain tissues. Results Melatonin and VA extract increased the sleep duration and decreased the sleep latency as compared to Pentobarbital group (P < 0.05), wherein the VA2 group showed significantly higher improvements in sleep latency compared to VA1 and melatonin groups (P < 0.05). Further, both groups of valerian (VA1 & VA2) and melatonin increased the serum levels of pro-sleep neurotransmitters; serotonin, melatonin, and dopamine along with increased expression of their receptors (GABAA R2, GABAB R1- R2, serotonin receptor, Glutamate receptors GluA1, GluN2A, and GluN1) in the brain tissues. We also observed increased expression of modulators of apoptotic pathway and reduced oxidative stress in valerian as well as melatonin groups. Conclusions Valerian extract 2% powder prolongs sleep duration and decreases sleep latency in a pentobarbital-induced sleep model in mice. Further valerian extract modulated the serum levels of all three pro-sleep neurotransmitters and enhanced the expression of various sleep promoting neuronal receptors of brain involved in sleep biology in a dose-dependent manner. Funding Sources OmniActive Health Technologies (India) and partially by the Turkish Academy of Sciences (Turkey).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249673350,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/cdn\/nzac064.026","PubMedCentral":"9193409","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/academic.oup.com\/cdn\/article-pdf\/6\/Supplement_1\/807\/44041925\/nzac064.026.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The optimum conditions for preparing, recording and processing of Methylene-Blue Sensitized Dichromated Gelatin depend on some atmospheric parameters of laboratory where the operations are carried-out and the optimum value of different parameters appropriate to different conditions must be determined by experiment. Int his paper these conditions as well as the quality control of DCG plates and the diffraction efficiency of holographic gratings registered on these plates are reported.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120137462,"openaccessinfo":{"externalids":{"MAG":"1972693154","ACL":null,"DOI":"10.1117\/12.251838","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In order to better guide training according to the training test data, this paper uses the method of the time series data analysis, to obtain the knowledge rules from the training data of rowing through analysis. Namely the basis of different training content and the test project, we establish the different threshold value, thus obtain the athlete training effect of different time: The training excessively slightly, training quantity oversized, the training result enhancing with steady steps. The knowledge rules may be provided to the trainer to formulate the training plan for reference, thus we can enhance the science training effect.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10795261,"openaccessinfo":{"externalids":{"MAG":"2154130538","ACL":null,"DOI":"10.1109\/ICFCSE.2011.87","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a new method to solve the minimization problem in a simultaneous reconstruction and segmentation (SRS) model for X-ray computed tomography (CT). The SRS model uses Bayes' rule and the maximum a posteriori (MAP) estimate on the hidden Markov measure field model (HMMFM). The original method [Romanov M, Dahl AB, Dong Y, Hansen PC. Simultaneous tomographic reconstruction and segmentation with class priors. Inverse Problems Sci Eng. 2016;24(8):1432\u20131453] includes a subproblem with logarithmic-summation (log-sum) term, which is non-separable to the classification index. This subproblem was solved by Frank\u2013Wolfe algorithm, which is very time consuming especially when dealing with large-scale CT problems. The starting point of this paper is the commutativity of log-sum operations, where the log-sum problem could be transformed into a sum-log problem by introducing an auxiliary variable. The corresponding sum-log problem for the SRS model is separable. By applying the primal-dual algorithm, the sum-log problem turns into several easy-to-solve convex subproblems. In addition, we introduce an improved model by adding Tikhonov regularization on the SRS model, and give some convergence results for the proposed methods. Experimental results demonstrate that the proposed methods produce comparable results compared with the original SRS method with much less CPU time.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":231741430,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/17415977.2021.1999941","PubMedCentral":null,"ArXiv":"2102.00250"},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17415977.2021.1999941?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Diabetes Mellitus (DM) is a widespread disease and a serious public health problem. Low Level LASER Therapy (LLLT) has been found to reduce glycaemia on DM type 1 patients, an observation requiring further research especially as regards characteristics of treatment protocol. The purpose of this work is to continue the line of research and propose a specific protocol for LLLT use. In spring 2008 a 48 year old man, DM type 1 insulin dependent patient has been submitted to 810 nm wavelength LLLT treatment in specific body areas daily for 3 weeks and then once a week for 4 weeks until normalization of glycaemia. Medical supervision was present before, during and after application. Insulin was reduced progressively and then stopped. A gradual reduction of glycaemia was noted during the course of treatment. In successive follow\u2010ups a reduction in HbA1c was noted. Results confirm previous observations and need for further research on large cohorts. The indication that LASER may become a valuable addition to DM t...","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":71167512,"openaccessinfo":{"externalids":{"MAG":"2002369436","ACL":null,"DOI":"10.1063\/1.3175635","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"he human immunodeficiency virus (HIV) is the cause of the HIV\/AIDS pandemic affecting millions of people around the world. Treatment with antiretroviral drugs, if used properly, leads to a dramatic decrease in virus production in the patient and prevents the onset of AIDS. However, treatment is not always successful, mainly due to the extraordinary ability of the virus to change and become resistant to the antiretroviral drugs. T The general aim of this thesis was to study the development of HIV-1 drug resistance, specifically the detection and significance of small populations of drug-resistant virus in infected individuals that can go undetected by the standard resistance tests used in the clinics today. In study I, we developed and evaluated an assay called selective real-time PCR (SPCR), which can detect and display the proportions of different populations of drug-resistant virus carrying the clinically relevant M184I\/V mutations in the HIV-1 reverse transcriptase enzyme. These mutations confer high-level resistance to one of the most commonly used drugs today, lamivudine (3TC). The SPCR assay was then applied to several different clinical cohorts in the subsequent papers. We found SPCR to be a well-functioning, sensitive and reliable method to study the kinetics of antiretroviral resistance development in HIV-1, which was able to detect resistance mutations not seen by conventional genotyping assays. In study II, we evaluated the presence of M184I\/V-containing minor viral populations and their potential role in treatment failure in didanosine (ddI)-treated patients experienced with multiple nucleoside reverse transcriptase inhibitors. We found that the survival advantage of virus strains having the M184I\/V mutations were limited during ddI treatment, suggesting that the presence of these mutations should not preclude the use of ddI in nucleoside-experienced patients. In study III, we investigated to which extent unique drug resistance patterns appear in cerebrospinal fluid as compared to blood in patients who had failed 3TC-containing therapy. We found differences in drug resistance patterns in both minor and major populations, which were likely to be related to differences in the selective pressure of antiretroviral drugs within the two compartments rather than unique evolutionary pathways. Minor populations were not seen to play a major role in resistance development in cerebrospinal fluid in the patients we tested. In study IV, we studied to which extent selection of M184I\/V mutations occurs in treatmentnai ve patients during the first months after initiation of antiretroviral therapy containing two, three or four drugs. We found the selection of drug-resistant variants to be rare in the threeand four-drug cohorts, but common in the two-drug cohort, suggesting that current treatment regimens initiated in treatment-nai ve patients should be sufficient to stop resistance development during the first phase of viral decay, as long as the patients are adherent. The clinical significance of minority populations in the development of resistance to antiretroviral drugs is an important topic to be defined. SPCR and similar assays will provide valuable tools to further expand the current knowledge in this field. LIST OF PUBLICATIONS I. Tobias Bergroth, Zhibing Yun, Anders So nnerborg. Discrimination of lamivudine resistant minor HIV-1 variants by selective real-time PCR. Journal of Virological Methods 2005, 127:100-107 II. Veronica Svedhem, Tobias Bergroth, Knut Lidman, Anders So nnerborg. Presence of M184I\/V in minor HIV-1 populations of patients with lamivudine and\/or didanosine treatment failure. HIV Medicine 2007, 8:504-510 III. Tobias Bergroth, Halime Ekici, Magnus Gissle n, Lars Hagberg, Anders So nnerborg. Comparison of drug resistance patterns in minor and major HIV-1 populations in plasma and cerebrospinal fluid. Submitted IV. Tobias Bergroth, Halime Ekici, Magnus Gissle n, Sabine Kinloch-de Loes, LiEan Goh, Andrew Freedman, Margaret A Johnson, Anders So nnerborg. Drugresistant HIV appears seldom during the early phase of viral decay in patients initiated on threeor four-drug ART. Submitted","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":70865075,"openaccessinfo":{"externalids":{"MAG":"1787424918","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study describes a method for detecting and tracking ocean fronts using multiple autonomous underwater vehicles (AUVs). Multiple vehicles, equally spaced along the expected frontal boundary, complete near parallel transects orthogonal to the front. Two different techniques are used to determine the location of the front crossing from each individual vehicle transect. The first technique uses lateral gradients to detect when a change in the observed water property occurs. The second technique uses a measure of the vertical temperature structure over a single dive to detect when the vehicle is in upwelling water. Adaptive control of the vehicles ensure they remain perpendicular to the estimated front boundary as it evolves over time. This method was demonstrated in several experiment periods totaling weeks, in and around Monterey Bay, CA, in May and June of 2017. We compare the two front detection methods, a lateral gradient front detector and an upwelling front detector using the Vertical Temperature Homogeneity Index. We introduce two metrics to evaluate the adaptive control techniques presented. We show the capability of this method for repeated sampling across a dynamic ocean front using a fleet of three types of platforms: short\u2010range Iver AUVs, Tethys\u2010class long\u2010range AUVs, and Seagliders. This method extends to tracking gradients of different properties using a variety of vehicles.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":116864315,"openaccessinfo":{"externalids":{"MAG":"2905436396","ACL":null,"DOI":"10.1002\/rob.21853","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Reconfigurable computing is a promising approach with both flexibility and efficiency for high performance computing. However, the overhead of run-time reconfiguration affects the performance severely. In the paper, we develop a simple and effective method to hide the latency of configuration by configuration prefetching at runtime. A simulation platform based on Simics is developed for evaluation. The experimental results show that the predictive accuracy is rather high, the hit rate of reconfigurable processing unit is increased by 24.6%\u223c53.7% when reconfigurable resource is not adequate.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":21226771,"openaccessinfo":{"externalids":{"MAG":"2098168562","ACL":null,"DOI":"10.1109\/SOCC.2010.5784651","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"X-ray micro-tomography (XMT) and 3D image-based modelling software has unlocked the ability to digitally repair distorted or broken fossil specimens, thus permitting interpretation of previously unusable finds in finite element analyses (FEA). A fossilized terminal ungual phalanx from the manus of the dromaeosaur Velociraptor mongoliensis (Manchester Museum, University of Manchester, specimen LL.12392) was scanned at the Henry Moseley X-ray Imaging Facility. Inspection of radiographs revealed the Velociraptor manual ungual was broken in several places, previously going unnoticed due to cement repair of the fossil. After conducting a high resolution scan of the ungual the increased sensitivity of the apparatus enabled separation of areas of differing density, in this case the fossilized bone and cement. Image-based modelling software produced by Simpleware (Simpleware Ltd, Rennes Drive, Exeter, EX4 4RN, UK.) allowed slice-by-slice repair in three planes, resulting in a complete, fully stitched 3D digital model of the ungual, whilst maintaining internal cavities and the micron resolution reconstruction of trabecular bone architecture. This software also has the capability to digitally re-inflate specimens that have been compressed during fossilization, restoring skeletons to their original shape and dimension. 3D dissections on geometrically precise reconstructions allow the interpretation of previously unusable specimens and reinterpretation of already described fossils. Further, use of Simpleware software to convert repaired fossils into microstructurally-faithful finite element meshes enable the biomechanical testing of these repaired structures. Testing of fossil structure and function is already underway at the University of Manchester and is adding to our knowledge of the mechanical behaviour of extinct animal biomaterials.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":110618992,"openaccessinfo":{"externalids":{"MAG":"2303241884","ACL":null,"DOI":"10.55468\/gc228","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.geocurator.org\/fulltext\/files\/geocurator_9_3_pp193-198.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Munida subrugosa and M. gregaria are very abundant in the southern hemisphere, especially off New Zealand and South America. The specific identity of both species is still controversial and accurate identification is needed for conservation or ecological purposes. In this study we used univariate and multivariate methods to determine the morphological differences between both species\/morphs. Analyses of covariance of ten morphological variables regressed individually on the carapace length demonstrated that the carapace (including rostrum) and eyestalks (EL) were longer, and the anterior carapace (ACW), the rostrum basis (RBW), and dactylus (DaW) and propodus (PW) of the third maxilliped were wider in M. gregaria than in M. subrugosa. In contrast, the carapace, mandible and eyestalk were wider and the rostrum was longer in M. subrugosa compared to M. gregaria. A stepwise discriminant analysis found that five body measurements namely DaW, EL, PW, RBW and ACW, were useful to discriminate between both species\/morphs. The difference between the two discriminant functions provides an objective decision rule for the classification of both species\/morphs. We also present the linear relationships of wet and dry masses on size, for use in biomass estimations of Munida spp. as prey.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":86073273,"openaccessinfo":{"externalids":{"MAG":"2142030333","ACL":null,"DOI":"10.1017\/S0025315406014123","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The health status of 18 sweet corn (Zea mays L. saccharata Sturt) hybrids classified to two types, collected from five areas in China, was examined by PDA method, and factors influencing seed health and relationships between seed health and field seedling emergence were studied. Seventeen fungal genera were isolated and Fusarium was the most frequently isolated. There were significant differences both in incidence of Fusarium and in percentage of infected seeds among 18hybrids. Research also showed that significant and consistent differences both in seed-borne fungal taxa and in percentage of infected seeds existed between two types of sweet corn. Sugar enhanced corn is more slightly infected than super sweet corn both in fungal taxa (13 and 16, respectively) and in percentage of infected seeds (62.0 and 79.2%, respectively).There were also significant differences both in seed-borne fungal taxa and in percentage of infected seeds among five areas. Seeds from South China were most severely infected, for there were 14 fungal genera detected and the percentage of infected seeds was highly 99.1% while those from Northwest China were slightly infected, for there were 10 fungal genera detected and the percentage of infected seeds was only 14.3%. Further research showed that there were significant negative correlations both between incidence of Fusarium and percentage of field seedling emergence and between percentage of infected seeds and percentage of field seedling emergence. Percentage of field seedling emergence could be estimated by regression equations built by regression analysis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85793602,"openaccessinfo":{"externalids":{"MAG":"2253869629","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A typical grid-connected hybrid microgrid has one AC microgrid and one DC microgrid, which is considered for this system. Alternate of deploying the parallel-connected power converters, these microgrids are having all constituent parts linked\u00a0deploying to make partial changes UIPC. The traditional construction of UIPC, which conveys three power converters in each stage, is rolled out incomplete improvements so the check of power converters is executed for power trade control between AC-DC microgrids. The substitute situating involves one power converter in each stage, named as line power converter, and transport power converter. The AC microgrid is united to the main grid into the LPCs which their DC transports are related and can set off in capacitance mode. A fuzzy regulator is conveyed in the lead representative development of the LPCs. The fuzzy framework is registered dependent on H\u221e separating strategy to diminish the mistakes in enrollment capacities design. From start to the completion the BPC, the DC voltage of LPCs is contributed by the DC microgrid. Nonetheless, since the DC microgrid voltage is on condition that here by a PV framework, the DC interface voltage of the LPCs is rising and falling sporadically in number. Subsequently, as the beneficiation to hold consistent the DC connect dissimilarities, another nonlinear unsettling influence eyewitness based powerful different surface sliding mode control game plan is administered for DC side control of the BPC. The results build up the adequacy of the set forward power stream control approach of the improved UIPC for mixture microgrids.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":236631963,"openaccessinfo":{"externalids":{"MAG":"3170176946","ACL":null,"DOI":"10.17762\/TURCOMAT.V12I10.5107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During storage, red blood cells intended for transfusion undergo progressive changes affecting survival and function. Some of these in vitro changes are partly restored in vivo after transfusion, and their clinical effects are largely unknown. We evaluated publications of clinical studies comparing storage times in connection with red blood cell transfusion using physiological or clinical outcomes. A few prospective randomised studies in humans investigated physiological outcomes or oxygen kinetics. Sixteen observational studies comparing clinical outcome yielded contradictory results regarding the effect of red cell storage on mortality, length of intensive care and hospital stay, infections, organ failure, and composite adverse effects. The use of different red blood cell products further obscures the issue. Available studies provide no evidence that longer stored red cells are more harmful than younger red cells. However, such an effect may occur under extreme clinical conditions of severe anaemia or septicaemia, but this can only be answered by randomised studies controlling for confounding factors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3706680,"openaccessinfo":{"externalids":{"MAG":"2018052149","ACL":null,"DOI":"10.1159\/000155221","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.karger.com\/Article\/Pdf\/155221","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"4 Burns patients often suffer severe pain during interventions such as dressing changes, even 5 with analgesia. Virtual Reality (VR) can be used to distract patients and reduce pain. 6 However, more evidence is needed from the patients and staff using the technology about its 7 use in clinical practice and the impact of different VR strategies. This small-scale qualitative 8 study explored patient and staff perceptions of the impact and usability of active and passive 9 VR during painful dressing changes. Five patients took part in three observed dressing 10 changes one with an active VR scenario developed for the study, one with passive VR and 11 one with no VR following which they were interviewed about their experiences. Three 12 nurses who performed the dressing changes participated in a focus group. Thematic analysis 13 of the resulting data generated four themes: 'Caution replaced by contentment', 'Distraction 14 and implications for pain and wound care', 'Anxiety, control and enjoyment' and 'Preparation 15 and communication concerns'. Results suggested that user-informed active VR was 16 acceptable to burn patients, helped manage their perceived pain, and was both usable and 17 desirable within the clinical environment. Further testing with larger samples is now required. 18","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221791063,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using lectin binding, we characterized subdomains of the rough endoplasmic reticulum (rER) in goblet cells of the rat colon. In this cell type, special rER regions can be differentiated on the basis of their content of low electron density and dilated cisternal spaces in conventional transmission electron microscopic preparations. The fine fibrillar content of these cisternal regions demonstrated high-affinity binding with lectins from wheat germ, Helix pomatia, Griffonia simplicifolia I-A4 and -B4, and Ricinus communis I, although not with the sialic acid-specific Limax flavus lectin and the fucose-binding Ulex europaeus I lectin. Sugar-inhibitory experiments indicated that glycoconjugates packed within these regions bound the lectins with higher affinity than molecules present in the Golgi apparatus and secretory granules. Furthermore, the lectin binding patterns of the rER subdomains differed from those of the Golgi apparatus and mucin granules: the terminal sugar residues sialic acid and fucose were demonstrable in the Golgi apparatus and mucin granules and were absent from the rER, while galactose-recognizing lectins bound intensely at these rER regions, weakly to Golgi elements, and were almost absent from mucin granules.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38748447,"openaccessinfo":{"externalids":{"MAG":"2090863927","ACL":null,"DOI":"10.1177\/40.7.1607641","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/40.7.1607641","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Specific biomarkers in a readily accessible biological fluid, such as blood, could aid in the identification, characterization, validation, and routine monitoring of Alzheimer's disease (AD) progression. In the current study, levels of the previously described novel cerebrospinal fluid aberrant protein complex composed of prostaglandin-D-synthase (PDS) and transthyretin (TTR) were quantified in plasma by a custom two-probe sandwich ELISA and compared to amyloid-\u03b2 (A\u03b2)(1-42) as a standard plasma biomarker of AD. Plasma was analyzed from 140 probable AD subjects, 135 subjects with mild cognitive impairment (MCI), 74 normal control subjects (NC) prior to MCI transition, 23 diseased control (DC) subjects with either frontotemporal dementia or dementia with Lewy bodies, and 182 normal control (NC) subjects who did not progress to MCI or dementia. Levels of A\u03b2(1-42) were significantly elevated in NC subjects prior to MCI conversion but significantly reduced in probable AD subjects compared to NC subjects. Similarly, levels of the PDS-TTR complex were significantly reduced in both MCI and probable AD subjects compared to NC subjects. Furthermore, levels of A\u03b2(1-42) and the PDS-TTR complex were not significantly different in DC subjects compared to NC subjects. MMSE scores were weakly but significantly correlated with plasma levels of the PDS-TTR complex and A\u03b2(1-42). Trail B scores were weakly but significantly correlated with plasma levels of A\u03b2(1-42). Comparison of receiver operating curves shows the PDS-TTR complex is comparable to A\u03b2(1-42) in both MCI and probable AD subjects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12913754,"openaccessinfo":{"externalids":{"MAG":"2211812585","ACL":null,"DOI":"10.3233\/JAD-150183","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we describe the starting materials and the experimental conditions used to prepare hydrogels, based on dextran, by radical copolymerization, which are appropriated for pharmaceutical and biomedical applications. pH-sensitive hydrogel microspheres composed of glycidyl methacrylate dextran (GMD) and methacrylic acid (MA) were prepared by radical copolymerisation for drug delivery. GMD was synthesized by coupling of glycidyl methacrylate to dextran. A water solution of GMD, MA and N,N' ethylene bis acrylamide (EBA) was added to an organic phase (n-hexane and carbon tetrachloride); the mixture was treated with Span85, Tween85, N,N,N',N' tetramethylethylendiamine and ammonium peroxydisulfate (radical initiator). The microspheres obtained showed narrow dimensional distribution, spherical shape, high swelling ratio and a pH dependent swelling behavior that increased in basic medium.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":222850003,"openaccessinfo":{"externalids":{"MAG":"2993990339","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we report on a set of measurements performed at University of Ottawa to investigate the effects of rotation on the parameters of the indoor infrared channel model. The infrared channel is characterized by measuring the amplitude and phase response of its transfer function. The measurements have been performed in rooms with different shapes and physical properties. In each position, the receiver is rotated in steps of 5\/spl deg\/ and the channel transfer function is recorded in each step. Also, in each position, this set of results is collected for both diffuse and line-of-sight (LOS) configurations. Measurements are done in 9 rooms and a total of more than 5000 frequency responses have been collected. In this paper, we elaborate on the measurement set up, measurement procedures and present some of the results.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":62313930,"openaccessinfo":{"externalids":{"MAG":"2123246128","ACL":null,"DOI":"10.1109\/VETEC.1998.686128","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the development of the electronic archives in high-energy physics, there has been increasing questioning of the role of traditional publishing styles, particularly in the production of conference books. One aspect of traditional publishing that still receives wide appreciation, however, is in the production of well-focussed pedagogical material. The present two-volume edition, 'Supersymmetric Mechanics\u2014Vol 1', edited by S Bellucci and 'Supersymmetric Mechanics\u2014Vol 2', edited by S Bellucci, S Ferrara and A Marrani, is a good example of the kind of well-digested presentation that should still find its way into university libraries. This two-volume set presents the material of a set of pedagogical lectures presented at the INFN National Laboratory in Frascati over a two-year period on the subject of supersymmetric mechanics. The articles include the results of discussions with the attending students after the lectures. Overall, this makes for a useful compilation of material on a subject that underlies much of the current effort in supersymmetric approaches to cosmology and the unification programme. The first volume comprises articles on 'A journey through garden algebras' by S Bellucci, S J Gates Jr and E Orazi on linear supermultiplet realizations in supersymmetric mechanics,'Supersymmetric mechanics in superspace' by S Bellucci and S Krivonos, 'Noncommutative mechanics, Landau levels, twistors and Yang\u2013Mills amplitudes' by V P Nair, 'Elements of (super) Hamiltonian formalism' by A Nersessian and 'Matrix mechanics' by C Sochichiu. The second volume consists entirely of a masterful presentation on 'The attractor mechanism and space time singularities' by S Ferrara. This presents a comprehensive and detailed overview of the structure of supersymmetric black hole solutions in supergravity, critical point structure in the scalar field moduli space and the thermodynamic consequences. This second volume alone makes the set a worthwhile addition to the research library of any university active in fundamental theoretical physics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250857304,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0264-9381\/24\/17\/B02","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper draws on case studies of efforts by transnational civil society coalitions to influence projects and policies of the World Bank to develop lessons about policy influence campaigns. The paper argues that transnational coalitions that succeed in influencing multilateral institutions (1) fit campaigns to their targets, (2) open up the \"cracks\" in the system, (3) recognize various forms of impact, and (4) create footholds that give a leg up to those who follow. Accountability within coalitions depends on (5) building local bases, (6) building interorganizational \"chains\" to bridge gaps among coalition members, (7) using face-to-face negotiations to build trust and shared expectations, and (8) recognizing the power of small actors in the right chains.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":152790282,"openaccessinfo":{"externalids":{"MAG":"1535924756","ACL":null,"DOI":"10.2139\/SSRN.254272","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In an attempt to improve hemopoietic recovery after autologous bone marrow transplantation (ABMT), a project of peripheral blood stem cells (PBSC) harvest was initiated. Thirty-six children awaiting ABMT underwent 126 PBSC harvests primed by a conventional scheduled chemotherapy course and rGMCSF 5 micrograms\/kg per day\/s.c. Ages ranged from 12 months to 19 years and weight from 9 to 84 kg. PBSC harvest was carried out using the Fenwall CS 3000 Plus with the small volume collection chamber at a maximum whole blood flow rate of 15-45 ml\/min; total volume processed was 1,700-10,000 ml. Total nucleated cells per collection was 0.35-5.62 x 10(8) cells per kg, and the number of CD34+ cells, 0.23-1.1 x 10(6)\/kg. The number of colony forming units-granulocyte macrophages (CFU-GM) varied in these heavily pretreated patients from 0 to 5.3 CFU-GM x 10(4)\/kg per collection. Immunophenotyping of the cells collected was performed by double staining for CD34, CD33, CD15, CD71, Ia and CD56. Most of the CD34+ cells were found to be CD38+; some were CD33+ and some CD33-. Low coexpression of CD34+ CD71+ cells may correlate with the low proliferating capacity of PBSC as compared to the BM cells. To date 22 children have undergone transplantation using combined autologous PBSC and bone marrow. We conclude that PBSC harvest is a feasible and safe procedure even in small children, and can be successfully performed following scheduled chemotherapy and administration of growth factors, resulting in substantial yield, also in heavily pretreated patients. This procedure is recommended in responding high risk patients at the stage of minimal residual disease and may replace ABMT in the future.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":24414611,"openaccessinfo":{"externalids":{"MAG":"2409726108","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Text readability is very important in meeting people's information needs. With the explosive growth of modern information, the measurement demand of text readability is increasing. In view of the text structure of words, sentences, and texts, a hybrid network model based on convolutional neural network is proposed to measure the readability of English texts. The traditional method of English text readability measurement relies too much on the experience of artificial experts to extract features, which limits its practicability. With the increasing variety and quantity of text readability measurement features to be extracted, it is more and more difficult to extract deep features manually, and it is easy to introduce irrelevant features or redundant features, resulting in the decline of model performance. This paper introduces the concept of hybrid network model in deep learning; constructs a hybrid network model suitable for English text readability measurement by combining convolutional neural network, bidirectional long short-term memory network, and attention mechanism network; and replaces manual automatic feature extraction by machine learning, which greatly improves the measurement efficiency and performance of text readability.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247487190,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2022\/6984586","PubMedCentral":"8940551","ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/cin\/2022\/6984586.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In an era of rapid technological progress and major political and economic transformations accross the globe, the ability to acquire internationally becomes an important skill for internationalizing companies. Cross border mergers and acquisitions are growing rapidly in importance precisely becuase they provide firms with the fastest way of acquiring tangible and intabgible assets in different countries. However due to problems with coordinating and reconfiguring resources in an internationally dispersed network, transferring best practices accross units, retaining key personnel and exchanging knowledge across geographically dispersed units, a lot of international acquisitions fail or underperform. While it is now accepted that learning from acquisition experience is one of the key ways of building successful routines for making acquisitions our understanding of what experiences could be useful for acquiring companies and in what way internationalizing companies learn to benefit from them is limited. The three studies presented in this thesis contributed to prior literature by explicitly addressing those issues. We proposed that in order to understand how organizations learn from their experiences it is not only importanrt to consider the performance of their acquisitions but also the amount of acquisitions that companies can absorb to build workable and usable routines over time.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":110092790,"openaccessinfo":{"externalids":{"MAG":"2113812891","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The overhead crane exhibits the double-pendulum dynamics because of the large-mass hook. The nonlinear dynamic model of the double-pendulum-type overhead crane is built using the Lagrangian method. Several properties of the system model such as the underactuated property, the passivity, and its two nature frequencies are analyzed. An adaptive sliding mode fuzzy control method is proposed for double-pendulum-type overhead crane. The method greatly reduces the rules of regular fuzzy logic controller and well utilizes some adaptive methods of sliding mode controller. Simulation results illustrate the complex system dynamics of the double-pendulum-type overhead crane and the proposed control algorithm.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":23705413,"openaccessinfo":{"externalids":{"MAG":"2170377540","ACL":null,"DOI":"10.1109\/ICMLC.2004.1380723","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Melanomas of the gallbladder (GB) are extremely rare with a very poor prognosis. They feature in the literature as a few case reports and the method of their management is not clear. We report a case of patient with metastatic cutaneous melanoma to the GB, and our treatment suggestion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17408970,"openaccessinfo":{"externalids":{"MAG":"2060962399","ACL":null,"DOI":"10.1002\/ccr3.121","PubMedCentral":"4270716","ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/ccr3.121","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Leaves of healthy tulip plants \"William Pitt\" (WP) in shooting stage (shoot-length 5-10cm above the ground) were inoculated with leaf- or petal-sap expressed from freeze-dried tissues of suspected tulip plants for the purpose of knowing if the latter is actually virus-infected. By the partial break (Fig. 1, left) that subsequently appear on the WP flower, it was judged whether unusual coloration in flower or foliage of the suspected plants was due to virus disease or of inherent nature.1. When leaf-sap from yellow (\"Golden Harvest\") or white tulips (\"Mrs. Grullemans\" and \"White Duchess\") bearing red lines or sprashes on petals was inoculated, no WP flowers showed partial-break. On the other hand, leaf-sap from these varieties showing leaf streaks produced partial-break on WP flower. Therefore, it seems unlikely that red lines or sprashes on petals of yellow or white varieties are due to virus disease.2. It was demonstrated that blotched or feathered flowers of dark purple tulips (\"Queen of the Night\" and \"Van der Neer\") had been caused by virus infection, bacause WP flower showed partial-break by the inoculation of leaf-sap from these plants.3. It was also demonstrated that the flower symptom of bi-colored variety \"Pink Beauty\" in which ground color was visible in the pink area was due to virus disease.4. Leaf-sap from tulips of Parrot \"Sunshine\" and Double Late \"Nizza\" without leaf streaks did not produce partial-break on WP flower, suggesting that the flower variegations are not due to virus infection but due to the inherent nature of these varieties.5. It has been said that some \"Rembrandt\" tulips were derived from virus-infected Darwin tulip. In the present study, however, leaf-sap from \"American Flag\" plant bearing normal foliage did not cause flower breaking in WP, while leaf-sap from the plant bearing streaked foliage produced partial-break on WP flower. Therefore, it seems to assume that flower breaking of \"American Flag\" is not due to virus infection.6. \"Gudoshnik\", one of the varieties of Darwin Hybrid, exhibits a wide range of variation in flower color. Leaf- or petal-sap from some individuals of this variety did not produce partial-break on WP flower upon inoculation. The color variation may be due to the inherent nature of this variety.7. With the exception of \"Hydra\", leaf-sap from all varieties tested that are called \"Variegated-Leaved\" did not produce partial break on WP flower, irrespective of the variegation in leaf color is regular or irregular. They are \"Cochinille\", \"Peach Blossom\", \"Purple Kroon\", \"Rose Luisante\", \"Yellow Prince\", and \"William Pitt\". Of course, WP was readily infected by sap-inoculation from \"Rose Luisante\" plants that have either leaf streaks in green area other than leaf variegation or broken flowers. These facts may suggest that \"Variegated-Leaved\" might have been selected from genetical mutants.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":84362039,"openaccessinfo":{"externalids":{"MAG":"2042198955","ACL":null,"DOI":"10.2503\/JJSHS.32.326","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Taeniid tapeworm Echinococcus granulosus is the causative agent of Echinococcosis, an important zoonosis with worldwide distribution. In this study, a diagnostic antigen P-29 was cloned from E. granulosus and expressed in Escherichia coli. Sequence analysis showed that EgP-29 contains 717-bp open reading frame and encodes a protein of 238 amino acid residues with a predicted molecular weight of 27.1 kDa. The recombinant EgP-29 (rEgP-29) could be recognized with antimice sera in Western blotting. The specific antibody was detected by enzyme-linked immunosorbent assay. Mice vaccinated with rEgP-29 and challenged intraperitoneally with E. granulosus protoscoleces revealed significant protective immunity of 96.6% (P<0.05), compared with the control group. Thus, rEgP-29 protein is a promising candidate for an effective vaccine to prevent secondary echinococcosis.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":16956873,"openaccessinfo":{"externalids":{"MAG":"2162068725","ACL":null,"DOI":"10.1093\/ABBS\/GMN009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Shariah committees ( SCs ) of Islamic banks have the crucial governance role of providing Shariah compliance assurance. In order to maintain the integrity of the bank in conforming with religious faith SBs should have the talent and skills for an effective monitoring which among others include contributing to Shariah audit task. To gain an in-depth understanding on the Shariah compliance audit role of SB , our present study has performed semi-structured intrerviews with 14 key players at two fully-fledge Islamic banks. Our study shows that the diverse Shariah and non-Shariah backgrounds of SB members could result in a more holistic view of Shariah issues, being more vocal in giving opinion and critism on the Shariah audit practices undertaken by Islamic banks. However, our findings reveal the existence of imbalance competency among SB members and the absence of proper Shariah audit framework in the two banks governance framework. As a result, most of the SB members delegate their Shariah audit role to be mainly performed by their Shariah audit division whose outcome will be submitted to them for approval. We argue that this passive role of SB members triggers concern on their independence and, consequently, compromised the Shariah compliance assurance provided to stakeholders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248384737,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes equilibrium prices under incomplete and biased information provided to consumers by price-comparison search engines. Theoretical results predict a conflict of interests between users and non users of these engines. More (unbiased) information does not necessarily increase welfare. Experimental evidence supports some of the model's predictions and rejects others. Data analysis indicates that divergence between empirical and theoretical price distributions can partly be due to systematic effects of agents' attitudes towards risky choice. Two aspects of such attitudes are identified: a subject's degree of risk aversion and whether the subject's choices are compatible with theories assuming dominance. JEL classification: D43, D83, L13.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11268600,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Temporal Subtraction Technique is one of effective tools for diagnosis of lung cancer from thoracic CT images. By comparing two images of the same subject but shot at different time, the detection of temporal changing becomes facilitated. To acquire a more accurate subtraction image, the registration of these two images is critical. However it is not easy as the influence of the slight structures such as lung blood vessel. In this paper, a novel nonrigid image registration method based on vessel structure information is proposed. The similarity of the vessels structure is defined by means of the likelihood function of vessels structure and their direction. We combine this similarity of vessels with the intensity information of images. And the metrics are used as similarity measure in registration procedure. The proposed method has been applied to thoracic MDCT images, and the improvement of registration accuracy was investigated. The efficiency of our proposed method was indicated.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2524301,"openaccessinfo":{"externalids":{"MAG":"2018644436","ACL":null,"DOI":"10.1109\/ICSMC.2012.6377932","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome, and hundreds of them are evolutionary conserved, but their functions and modes of action remain largely obscure. Particularly enigmatic lncRNAs are those that are exported to the cytoplasm. We identified and characterized an abundant and highly conserved cytoplasmic lncRNA, which we denote Pumilio2-binding long intervening noncoding RNA (PUBLINC). Most of the sequence of this lncRNA is comprised of repetitive units that together contain at least 17 functional binding sites for PUM2, one of the two Pumilio homologs in mammals. Through binding to PUM2, PUBLINC modulates the mRNA levels and translation of PUM2 targets, enriched for genes involved in chromosome segregation during cell division. Our results suggest that some cytoplasmic lncRNAs function by modulating the activities of RNA binding proteins, an activity which positions them at key junctions of cellular signaling pathways.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":262151754,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since 2001, silica microspheres have been reported to be stabilized by highly charged hydrous ZrO(2) nanoparticles which form halos around the microspheres at pH 1.5. However, the exact mechanisms behind this novel stabilization method in terms of the relevant interaction forces remain unclear. In order to gain a greater insight into this mechanism, the interaction between a silica flat and a silica sphere in different ZrO(2) nanoparticle suspensions was investigated by the colloid probe technique. The interaction force between a silica flat and a 600 nm silica sphere was first investigated in a ZrO(2) nanoparticle (D approximately 8 nm) suspension with volume fractions of 10(-3), 10(-4), 10(-5), and 10(-6). When the volume fraction of ZrO(2) is 10(-6), only a purely attractive van der Waals force was observed between the silica surfaces. With an increase in the ZrO(2) nanoparticle volume fraction, a peak was detected on the transition force curve at a ZrO(2) volume fraction of 10(-5) while a purely repulsion force was observed for ZrO(2) volume fractions of 10(-4) and 10(-3). The average distance difference between the peak and the zero distance point on the transition force curve which should define the distance between the halo on the microsphere is approximately 2.3 nm. Additionally, the repulsion increases with the effective zeta potential of the binary composite sphere (BCS, the entity of the silica sphere and the surrounding zirconia particles) on an increase of the nanoparticle volume fraction while the adhesion force decreases, which indicates a denser nanoparticle halo.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24890870,"openaccessinfo":{"externalids":{"MAG":"1995445332","ACL":null,"DOI":"10.1021\/la804103g","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The authors delineate aspects of adolescent psychological development that should be considered in decisions regarding psychiatric residential treatment, reviewing the issue of consent to treatment in the context of developmental psychology. They state that rather than jettisoning the whole system of placing treatable disturbed young people in residential facilities without their explicit consent, the court should take as its proper role to ensure that adolescents placed in residential psychiatric facilities receive adequate treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12938934,"openaccessinfo":{"externalids":{"MAG":"2420469049","ACL":null,"DOI":"10.1176\/AJP.134.2.153","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We document that Algorithmic Traders (ATs) reduce analysts' stock coverage and the number of analyst research reports. This evidence reflects that ATs pre-empt trades on new information, which reduces non-AT investment-driven demand for analyst research. Consistently, the effects we document dominate (i) when analysts produce new information rather than simply disseminate public information; (ii) when there are more institutional investors demanding research for trading purposes rather than for monitoring purposes; (iii) for stock recommendations rather than earnings forecasts (as the latter also serve a monitoring purpose); (iv) when stock liquidity is higher, as ATs require high liquidity for profitable trades; (v) for smaller stocks where the analyst's reputational cost of dropping coverage is lower. We address endogeneity using firm-fixed effects, regressions in changes, and using a natural experiment based on the tick-size pilot programme. Overall, our results suggest that an unintended consequence of algorithmic trading is lower analyst research production.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":233763059,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.3597356","PubMedCentral":null,"ArXiv":null},"license":"public-domain","url":"https:\/\/ktisis.cut.ac.cy\/bitstream\/20.500.14279\/25455\/1\/SSRN-id3597356.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The mobilities of electrons have been measured from 15 K to 300 K on CZ-silicon crystals, which are initially P-type and then transformed into N-type after being heat-treated at 670 and 720\u00b0C, respectively. It has been found that the mobilities of electrons depend on the heat-treatment regime in a complicated manner provided the ionized impurity scattering is predominant. Based upon the model of new donors proposed, a new scattering process caused by charged precipitate is assumed. The theoretical calculations for mobilities of electrons were in agreement with experimental data and therefore the reliability of the assumption was demonstrated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250794572,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0031-8949\/37\/5\/025","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Summary form only given. Time spent by airline maintenance operators to solve engine failures and the related costs (flight delays or cancellations) are a major concern to SNECMA which manufacture engines for civilian aircraft such as BOEING 737s and Airbus A340s. The use of an intelligent diagnostic software contributes to improving customer support and reduces the cost of ownership by improving troubleshooting accuracy and reducing airplane downtime. However, classical rule based or model based expert systems are costly to develop and maintain. Our goal has been to improve the development of troubleshooting systems through case based reasoning (CBR) and data mining. These technologies reason from past cases, whose solution is known, rather than rules. New problems are solved by searching for similar problem solving experiences and by adapting the solutions that worked in the past, Our second objective was to acquire the capacity to produce systems which match the quality standard in the aeronautic industry in the given time frame. We aim at both assuring the quality of the core data mining and CBR software as well as the quality of the technical information that is fed into the system (case knowledge).","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":34745417,"openaccessinfo":{"externalids":{"MAG":"2103608526","ACL":null,"DOI":"10.1109\/ICDE.1997.582038","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"If music be the food of love, play on. Give me excess of it that, surfeiting, the appetite may sicken, and so die. That strain again, it had a dying fall. Oh, it came o'er my ear like the sweet sound, that breathes upon a bank of violets, Stealing and giving odor. Enough, no more. 'Tis not so sweet now as it was before. O spirit of love, how quick and fresh art thou, That, notwithstanding thy capacity Receiveth as the sea, nought enters there, Of what validity and pitch soe'er, But falls into abatement and low price Even in a minute. So full of shapes is fancy That it alone is high fantastical . \u2014William Shakespeare, Twelfth Night, Act 1, Scene 1","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":191531533,"openaccessinfo":{"externalids":{"MAG":"2765898449","ACL":null,"DOI":"10.1353\/LTR.2017.0005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Topologically non-trivial vacuum structure in gravity models with Cartan variables (vielbein and contortion) is considered. We study the possibility of vacuum space-time tunneling in Einstein gravity assuming that the vielbein may play a fundamental role in quantum gravitational phenomena. It has been shown that in the case of RP 3 space topology the tunneling between non-trivial topological vacuums can be realized by means of Eguchi-Hanson gravitational instanton. In Riemann-Cartan geometric approach to quantum gravity the vacuum tunneling can be provided by means of contortion quantum fluctuations. We define double self-duality condition for the contortion and give explicit self-dual configurations which can contribute to vacuum tunneling amplitude.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244078229,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Interfacial moments of an antiferromagnet are known for their prominent effects of induced coercivity enhancement and exchange bias in ferromagnetic-antiferromagnetic exchange-coupled systems. Here we report that the unpinned moments of an antiferromagnetic face-centered-cubic Mn layer can drive the magnetization of an adjacent Fe film perpendicular owing to a formation of intrinsic perpendicular anisotropy. X-ray magnetic circular dichroism and hysteresis loops show establishment of perpendicular magnetization on Fe\/Mn bilayers while temperature was decreased. The fact that the magnitude of perpendicular anisotropy of the Fe layer is enhanced proportionally to the out-of-plane oriented orbital moment of the Mn unpinned layer, rather than that of Fe itself, gives evidence for the Mn unpinned moments to be the origin of the established perpendicular magnetization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31066122,"openaccessinfo":{"externalids":{"MAG":"2327360188","ACL":null,"DOI":"10.1103\/PHYSREVLETT.110.117203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper challenges the difficult problem of automatic semantic correspondence between two given shapes which are semantically similar but possibly geometrically very different (e.g., a dog and an elephant). We argue that the challenging part is the establishment of a sparse correspondence and show that it can be efficiently solved by considering the underlying skeletons augmented with intrinsic surface information. To avoid potentially costly direct search for the best combinatorial match between two sets of skeletal feature nodes, we introduce a statistical correspondence algorithm based on a novel voting scheme, which we call electors voting. The electors are a rather large set of correspondences which then vote to synthesize the final correspondence. The electors are selected via a combinatorial search with pruning tests designed to quickly filter out a vast majority of bad correspondence. This voting scheme is both efficient and insensitive to parameter and threshold settings. The effectiveness of the method is validated by precision\u2010recall statistics with respect to manually defined ground truth. We show that high quality correspondences can be instantaneously established for a wide variety of model pairs, which may have different poses, surface details, and only partial semantic correspondence.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":6590861,"openaccessinfo":{"externalids":{"MAG":"1991405936","ACL":null,"DOI":"10.1111\/j.1467-8659.2009.01634.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/visgraph.cse.ust.hk\/projects\/shape_matching\/shape-matching.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Feeding high levels of zinc oxide to piglets significantly increased the relative abundance of ileal Weissella spp., Leuconostoc spp., and Streptococcus spp., reduced the occurrence of Sarcina spp. and Neisseria spp., and led to numerical increases of all Gram-negative facultative anaerobic genera. High dietary zinc oxide intake has a major impact on the porcine ileal bacterial composition.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":21810892,"openaccessinfo":{"externalids":{"MAG":"2123955317","ACL":null,"DOI":"10.1128\/AEM.03075-09","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article reviews the literature on sex work, highlighting ways in which women working in the sex industry are represented. The subjective experiences and voices of sex workers are seldom heard and their needs are consistently defined and represented by non-sex workers throughout history, in society and within academia. Historical representations have contributed to the stereotyping and stigmatization of sex workers. Academic research is consistently being done on sex workers instead of with them. However, arts-based methods allow for participatory, shared knowledge creation. Arts-based research also has the potential for empowerment, reaching the general public and changing negative stereotypes.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1}},"corpusid":145773309,"openaccessinfo":{"externalids":{"MAG":"2121729006","ACL":null,"DOI":"10.1177\/1363460713497214","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract : This project focused on the study of the effects of microstructural features on the fracture process of high temperature structural ceramic materials that operate under cyclic loading environments. The ability to model these effects and the prediction of the deformation behavior also become an important consideration, as it provides a direct link to the design cycle for both, processing and design engineers. The project evaluated cyclic effects, high cycle fatigue behavior, and elevated temperature effects under these conditions. Evaluation of the effects of cyclic loading are performed using pre-cracked tensile test specimens (PFT) and bulk specimens by Moire Interferometry. Development of finite element and simple micromechanical models for predictions of the observed behavior also presented. It is observed that hysteretic load-displacement loops arise as the primary characteristic of the behavior, although gross-slip behavior is seen under certain circumstances.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":133860970,"openaccessinfo":{"externalids":{"MAG":"66558217","ACL":null,"DOI":"10.21236\/ada384633","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A typical application of upper-limb exoskeleton robots is deployment in rehabilitation training, helping patients to regain manipulative abilities. However, as the patient is not always capable of following the robot, safety issues may arise during the training. Due to the bias in different patients, an individualized scheme is also important to ensure that the robot suits the specific conditions (e.g., movement habits) of a patient, hence guaranteeing effectiveness. To fulfill this requirement, this paper proposes a new motion planning scheme for upper-limb exoskeleton robots, which drives the robot to provide customized, safe, and individualized assistance using both human demonstration and interactive learning. Specifically, the robot first learns from a group of healthy subjects to generate a reference motion trajectory via probabilistic movement primitives (ProMP). It then learns from the patient during the training process to further shape the trajectory inside a moving safe region. The interactive data is fed back into the ProMP iteratively to enhance the individualized features for as long as the training process continues. The robot tracks the individualized trajectory under a variable impedance model to realize the assistance. Finally, the experimental results are presented in this paper to validate the proposed control scheme.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":262013177,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2309.08178","PubMedCentral":null,"ArXiv":"2309.08178"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The hugely popular early chapter book series re-emerges with a new look! Brand-new eye-catching cover art brings a modern feel to this classic monster series for young readers. The Bailey School soccer team hasn't had a lot of success, but their new coach seems like the woman to help whip them into shape. Coach Graves is a little rough around the edges, but she's good at what she does. That is until a strange old lady turns up at one of their practices. After that, Coach Graves has a vacant look in her eyes, mumbles and groans in response to the kids, and moves like she's back from the dead. Can the kids break the spell and bring their coach back to normal in time for their big game?","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":191040824,"openaccessinfo":{"externalids":{"MAG":"636129518","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Arden Bement, acting director of the U.S. National Science Foundation since 22 February is President Bush's choice to become NSF director, the White House announced on 15 September. If confirmed by the U.S. Senate, Bement would serve for a 6-year term expiring on 2 August 2010. Bement will continue to serve as acting NSF director until the full Senate approves his nomination. \n \nIn a memorandum to NSF staff, Bement stated, \"Although NSF faces significant challenges in the near future due to federal budget issues, I am committed to the policies and operations that have stood the test of time and have helped make NSF an extraordinary agency.\"","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140151542,"openaccessinfo":{"externalids":{"MAG":"2069398643","ACL":null,"DOI":"10.1029\/2004EO390004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reports on Zoom Obscura \u2013 an artist-based design research project, responding to the ubiquity of video-conferencing as a technical and cultural phenomenon throughout the Covid-19 pandemic. As enterprise software, such as Zoom, rapidly came to mediate even the most personal and intimate interactions, we supported and collaborated with seven independent artists to explore technical and creative interventions in video-conferencing. Our call for participation sought critical interventions that would help users counter, and regain agency in regard to the various ways in which personal data is captured, transmitted and processed in video-conferencing tools. In this design study, we analyse post-hoc how each of the seven projects employed aspects of counterfunctional design to achieve these aims. Each project reveals different avenues and strategies for counterfunctionality in video-conferencing software, as well as opportunities to design critically towards interactions and experiences that challenge existing norms and expectations around these platforms. prototyped interventions to produce unconventional means of collaborative communication through video-conferencing.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":247935001,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Objective To assess critically the scope for public health nutrition taxation within the framework of the global tax reform agenda. Design Review of the tax policy literature for global policy priorities relevant to public health nutrition taxation; critical analysis of proposals for public health nutrition taxation judged against the global agenda for tax reform. Setting The global tax reform agenda shapes decisions of tax policy makers in all countries. By understanding this agenda, public health nutritionists can make feasible taxation proposals and thus improve the development, uptake and implementation of recommendations for nutrition-related taxation. Results The priorities of the global tax reform agenda relevant to public health nutrition taxation are streamlining of taxes, adoption of value-added tax (VAT), minimisation of excise taxes (except to correct for externalities) and removal of import taxes in line with trade liberalisation policies. Proposals consistent with the global tax reform agenda have included excise taxes, extension of VAT to currently exempted (unhealthy) foods and tariff reductions for healthy foods. Conclusions Proposals for public health nutrition taxation should (i) use existing types and rates of taxes where possible, (ii) use excise taxes that specifically address externalities, (iii) avoid differential VAT on foods and (iv) use import taxes in ways that comply with trade liberalisation priorities.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":9958060,"openaccessinfo":{"externalids":{"MAG":"1968138946","ACL":null,"DOI":"10.1017\/S1368980010002053","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Savannah River Site (SRS) has been operating a nuclear fuel cycle since the 1950`s to produce nuclear materials in support of the national defense effort. The Department of Energy authorized the construction of the Defense Waste Processing Facility (DWPF) to immobilize the high level radioactive waste resulting from these processes as a durable borosilicate glass. The DWPF, after having undergone extensive testing, has been approved for operations and is currently immobilizing radioactive waste. To ensure reliability of the DWPF remote canyon processing equipment, a materials evaluation program was performed prior to radioactive operations to determine to what extent erosion\/corrosion would impact design life of equipment. The program consisted of performing pre-service baseline inspections on critical equipment and follow-up inspections after completion of DWPF cold chemical demonstration runs. Non-destructive examination (NDE) techniques were used to assess erosion\/corrosion as well as evaluation of corrosion coupon racks. These results were used to arrive at predicted equipment life for selected feed preparation equipment. It was concluded with the exception of the coil and agitator for the slurry mix evaporator (SME), which are exposed to erosive glass frit particles, all of the equipment should meet its design life.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":136533938,"openaccessinfo":{"externalids":{"MAG":"1530714354","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This notice establishes revised productivity screening guidelines and a revised upper limit on Medicare and Medicaid rates of payment for rural health clinic services furnished by independent rural health clinics. Payments under both programs for rural health clinic services are currently subject to productivity screening guidelines. These guidelines identify clinic costs that will not be reimbursed without special justification by the clinic. These revised guidelines on productivity conform to those set forth by the Bureau of Community Health Services (BCHS), Public Health Service for clinics receiving funds from that agency. We are also discontinuing use of a specific guideline for overhead costs for rural health clinics. In addition, we have set a new limit on payments using more recent data, but have retained the same methodology used in setting previous limits. The amount of the revised upper limit is $32.10 per visit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22009368,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Active Galactic Nuclei are fueled from material (gas or stars) that are in general far away from the gravitational influence of the central black hole, the engine thought to be responsible for their activity. The required material has a lot of angular momentum, that is a priori quite difficult to evacuate. The various dynamical mechanisms that may play a role in this game are reviewed, including m=2 perturbations (bars and spirals), m=1 perturbations (spirals, warps, lopsidedness), and tidal interactions between galaxies and mergers. In the latest stages of the merger, a binary black hole could be formed, and its influence on the dynamics and fueling is discussed. Starbursts are often associated with AGN, and the nature of their particular connection, and their role in the nuclear fueling is described. Evolution of the fueling efficiency with redshift is addressed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":9821959,"openaccessinfo":{"externalids":{"MAG":"2140750019","ACL":null,"DOI":"10.1142\/9789812811318_0006","PubMedCentral":null,"ArXiv":"astro-ph\/0010570"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/astro-ph\/0010570","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Landsoner is the abbreviation of extremely elastic reflection wave recording continues profiling with extremely small offset and vary wide band frequency. It has following characteristics: (a) Small-offset single is used; (b) Under situation of using hammer source can be excited and be received reflection wave with frequency 10Hz-4000Hz of depth of 1.200m; (c) It is unnecessary that the geophones f ixed on the ground. On this characteristics the wave with different frequency band can be got that can greatly rise resolution, and can keep away from the noise of acoustic wave, direct wave, reflected wave, surface wave, specially can keep away from the noise of vibration of pedestrians, cars and the other machines on a city. When using landsoner method survey line with broken line can be used. There is no need to statics in mountainous region for this method. On the time-section of figure of Landsoner a karst cave can clearly be reflected. Landsoner method has been successfully used in shallow high resolution survey in mountainous region or in a busy city, in survey karst caves, in geological prediction forward from working face in a tunnel construction and in examining quality ofconcrete structures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":223537657,"openaccessinfo":{"externalids":{"MAG":"2534009847","ACL":null,"DOI":"10.1071\/ASEG2010AB068","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Minimally invasive surgical procedures aim to minimize the trauma of the interventional process but still achieve a satisfactory therapeutic result. Tissue trauma is significantly less than that with conventional open procedures, offering the advantages of reduced post-operative pain, shorter hospital stay, more rapid return to normal activities and significant cost savings. Laparoscopic cholecystectomy is now a routinely performed procedure and has replaced conventional open cholecystectomy as the procedure of choice for symptomatic cholelithiasis. Public expectation and developments in instrumentation have fuelled this change. The physiological effects of intraperitoneal carbon dioxide insufflation combined with variations in patient positioning can have a major impact on cardiorespiratory function, particularly in elderly patients with co-morbidities. Intra-operative complications may include traumatic injuries associated with blind trocar insertion, gas embolism, pneumothorax and surgical emphysema associated with extraperitoneal insufflation. Appropriate monitoring and a high index of suspicion can result in early diagnosis of, and treatment of, complications. Laparoscopic cholecystectomy has proven to be a major advance in the treatment of patients with symptomatic gallbladder disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34266891,"openaccessinfo":{"externalids":{"MAG":"2013550049","ACL":null,"DOI":"10.1053\/BEAN.2001.0204","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Avian isolates of Escherichia coli were classified as virulent based on their isolation from chickens with natural cases of colisepticemia, production of colicin V, and complement resistance. A second group of isolates was designated as avirulent based on their isolation from healthy chickens, their inability to produce colicin, and their classification as sensitive or intermediate to the action of complement. In vitro assays of phagocytosis and oxidant production were performed in an attempt to correlate these activities with the ability of each group of bacteria to escape the specific host defense mechanisms of phagocytosis and killing. Although oxidant production regressed with significant linearity on percent phagocytosis, neither group (virulent or avirulent) differed in ability to stimulate peritoneal macrophage phagocytic and oxidant activity when opsonized with normal chicken serum. These results differ from those in mammalian species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23102199,"openaccessinfo":{"externalids":{"MAG":"2324136741","ACL":null,"DOI":"10.2307\/1591846","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract. PointNet has been widely considered as a popular representation for unstructured point clouds with the aim of classification and segmentation. To date, recent researches represent the limitation of the PointNet to pose estimation and alignment of real environment, due to the low performance in pattern learning to complex scenes. This paper presents an end-to-end deep learning method for point clouds registration of indoor environment. The proposed method involves three steps. Firstly, feature pre-processing extracts the key-points by adaptive Harris 3D algorithm and generate the local group by point grouping. Second, hierarchical feature learning network is trained to describe the local group as feature descriptors. Finally, loss function between feature descriptor is trained. The key contribution is that we innovatively use the key-points to generate multi-layer feature vector, which can provide the contextual local features of the indoor environment. The results shows that our method achieves comparable registration accuracy to the present state-of-art geometric methods in the indoor environment. We comprehensively validate the accuracy of our approach using S3DIS dataset. The high accuracy demonstrates that our method can be used in point clouds registration accurately.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":222262816,"openaccessinfo":{"externalids":{"MAG":"3048950684","ACL":null,"DOI":"10.5194\/isprs-archives-xliii-b2-2020-177-2020","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.5194\/isprs-archives-xliii-b2-2020-177-2020","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Herein, we report the first total synthesis of the trisaccharide and tetrasaccharide repeating units of P. penneri 26 and P. vulgaris TG155, respectively, having a common disaccharide unit, 3-\u03b1-l-QuipNAc-(1 \u2192 3)-\u03b1-d-GlcpNAc-(1 \u2192. Striking features of the targets are the presence of rare sugar units, l-quinovosamine and l-rhamnosamine, all joined through \u03b1-glycosidic linkages. Major challenges in the formation of 1,2-cis glycosidic linkages in the case of d-glucosamine, l-quinovosamine, and d-galactosamine have been addressed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259097920,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acs.orglett.3c01618","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and\/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and\/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Here we focus on the amygdalohippocampal area (AHi) that projects to MPOA and expresses oxytocin receptor, a hormone receptor mediating social behavior toward pups. We describe the activation of MPOA-projection AHi neurons in male mice by social contact with pups. Input mapping using the TRIO method reveals that MPOA-projection AHi neurons receive prominent inputs from several regions, including the thalamus, hypothalamus, and olfactory cortex. Electrophysiological and histologic analysis demonstrates that oxytocin modulates inhibitory synaptic responses on MPOA-projection AHi neurons. In addition, AHi forms the excitatory monosynapse to MPOA, and pharmacological activation of MPOA-projection AHi neurons enhances only aggressive behavior, but not parental behavior. Interestingly, this promoted behavior was related to social experience in male mice. Collectively, our results identified a presynaptic partner of MPOA that can integrate sensory input and hormonal state, and trigger pup-directed aggression. SIGNIFICANCE STATEMENT The medial preoptic area (MPOA) plays critical roles in parental behavior, such as motor control, motivation, and social interaction. The MPOA projects to multiple brain regions, and these projections contribute to several neural controls in parental behavior. In contrast, how inputs to MPOA are regulated by social and environmental information is poorly understood. In this study, we focus on the amygdalohippocampal area (AHi) that connects to MPOA and expresses oxytocin receptor. We demonstrate the disruption of the expression of parental behavior triggered by the activation of MPOA-projection AHi neurons. This behavior may be regulated not only by oxytocin but also by neural input from several regions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":215760032,"openaccessinfo":{"externalids":{"MAG":"3015290785","ACL":null,"DOI":"10.1523\/JNEUROSCI.0438-19.2020","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A major part of our knowledge about Computational Learning stems from comparisons of the learning power of different learning criteria. These comparisons inform about trade-offs between learning restrictions and, more generally, learning settings; furthermore, they inform about what restrictions can be observed without losing learning power. \n \nWith this paper we propose that one main focus of future research in Computational Learning should be on a structured approach to determine the relations of different learning criteria. In particular, we propose that, for small sets of learning criteria, all pairwise relations should be determined; these relations can then be easily depicted as a map, a diagram detailing the relations. Once we have maps for many relevant sets of learning criteria, the collection of these maps is an Atlas of Computational Learning Theory, informing at a glance about the landscape of computational learning just as a geographical atlas informs about the earth. \n \nIn this paper we work toward this goal by providing three example maps, one pertaining to partially set-driven learning, and two pertaining to strongly monotone learning. These maps can serve as blueprints for future maps of similar base structure.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":6493028,"openaccessinfo":{"externalids":{"MAG":"2295513070","ACL":null,"DOI":"10.4230\/LIPIcs.STACS.2016.47","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"THAT THE image seen through an ophthalmic prism is distorted is well known to every refractionist, and this distortion is especially apparent through large prisms, and even through the usual Risley rotary prisms. Although known qualitatively, a general quantitative discussion of this distortion has never appeared in the literature. This situation can be accounted for not only because of the mathematical complications involved but also, and probably more so, because of the general lack of interest in such distortion, except as a phenomenon to be tolerated. In 1927 Hartinger1calculated the magnitude of this distortion for particular prisms with plane surfaces, especially those of high deviating power. He did not give a quantitative description that was applicable to ophthalmic prisms in general. There has been more interest of late in this distortion because of its influence on stereoscopic spatial localization when ophthalmic prisms are worn before the two eyes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":28879219,"openaccessinfo":{"externalids":{"MAG":"1984916181","ACL":null,"DOI":"10.1001\/ARCHOPHT.1952.01700030126001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A static CMOS circuit that converts a redundant binary representation into a two's complement representation is presented. The structure and time delay of the resulting logic are identical to a standard carry look-ahead logic for adders. The resulting layout is very regular, has no diffusion gaps and can be expanded to any desired look-ahead length. The circuit can be used for both multiplication and division.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":109150507,"openaccessinfo":{"externalids":{"MAG":"2018825736","ACL":null,"DOI":"10.1049\/EL:19950791","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose - The purpose of this study is to re-examine the disclosure effect of stock splits and long-term performance after stock splits using stock split data over the past 10 years, and infer the motivation (signal or opportunism) of stock splits. In addition, we focus on exploring the determinants of the short- and long-term market response to stock splits. \nDesign\/methodology\/approach - We measure the short-term market response to a stock split and the long-term stock performance after the stock split announcement using the event study method. We analyze whether there is a difference in the long-term and short-term market response to a stock split according to various company characteristics through univariate analysis and regression analysis. \nFindings - In the case of the entire sample, a statistically significant positive excess return is observed on the stock split announcement date, and the excess return during the 24-month holding period after the stock split do not show a difference from zero. In particular, the difference between short-term and long-term returns on stock splits is larger in companies with a large stock split ratio, small companies, large growth potential, and companies with a combination of financial events after a stock split. \nResearch implications or Originality - The results of this study suggest that at least the signal hypothesis for a stock split does not hold in the Korean stock market. On the other hand, it suggests that there is a possibility that a stock split can be abused by the manager's opportunistic motive, and that this opportunism can be discriminated depending on the size of the stock split, corporate characteristics, and financing plan.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":258329838,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32599\/apjb.14.1.202303.73","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate the use of Bayesian networks to construct large-scale diagnostic systems. In particular, we consider the development of large-scale Bayesian networks by composition. This compositional approach reflects how (often redundant) subsystems are architected to form systems such as electrical power systems. We develop high-level specifications, Bayesian networks, clique trees, and arithmetic circuits representing 24 different electrical power systems. The largest among these 24 Bayesian networks contains over 1,000 random variables. Another BN represents the real-world electrical power system ADAPT, which is representative of electrical power systems deployed in aerospace vehicles. In addition to demonstrating the scalability of the compositional approach, we briefly report on experimental results from the diagnostic competition DXC, where the ProADAPT team, using techniques discussed here, obtained the highest scores in both Tier 1 (among 9 international competitors) and Tier 2 (among 6 international competitors) of the industrial track. While we consider diagnosis of power systems specifically, we believe this work is relevant to other system health management problems, in particular in dependable systems such as aircraft and spacecraft. (See CASI ID 20100021910 for supplemental data disk.)","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":2681393,"openaccessinfo":{"externalids":{"MAG":"1492388421","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Although understanding habitat relationships remains fundamental to guiding wildlife management, these basic prerequisites remain vague and largely unstudied for the wolverine. Currently, a study of wolverine ecology conducted in Montana, USA, in the 1970s is the sole source of information on habitat requirements of wolverines in the conterminous United States. The Montana study and studies conducted in Canada and Alaska report varying degrees of seasonal differences in wolverine habitat use. This article provides an empirical assessment of seasonal wolverine habitat use by 15 wolverines (Gulo gulo) radiotracked in central Idaho, USA, in 1992\u20131996. We controlled for radiotelemetry error by describing the probability of each location being in a habitat cover type, producing a vector of cover type probabilities suited for resource selection analysis within a logistic regression framework. We identified variables that were important to presence of wolverines based on their strength (significance) and consistency (variability in coeff. sign) across all possible logistic regression models containing 9 habitat cover types and 3 topographic variables. We selected seasonal habitat models that incorporated those variables that were strong and consistent, producing a subset of potential models. We then ranked the models in this subset based on Akaike's Information Criterion and goodness-of-fit. Wolverines used modestly higher elevations in summer versus winter, and they shifted use of cover types from whitebark pine (Pinus albicaulis) in summer to lower elevation Douglas fir (Pseudotsuga menziezii) and lodgepole pine (Pinus contorta) communities in winter. Elevation explained use of habitat better than any other variable in both summer and winter. Grass and shrub habitats and slope also had explanatory power. Wolverines preferred northerly aspects, had no attraction to or avoidance of trails during summer, and avoided roads and ungulate winter range. These findings improve our understanding of wolverine presence by demonstrating the importance of high-elevation subalpine habitats to central Idaho wolverines.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":40946143,"openaccessinfo":{"externalids":{"MAG":"2135741156","ACL":null,"DOI":"10.2193\/2006-559","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction: Extubation can be associated with an adverse hemodynamic or respiratory response, which may be serious in cardiovascular written or in the elderly. The present study was conducted with the aim of investigating the effect of two different doses of dexmedetomidine in the prevention of extubation complications. Methods: This randomized clinical trial was conducted in Isfahan in 2020-2021 on 174 patients undergoing elective surgery. Patients were randomly divided into 3 groups receiving dexmedetomidine 1 \u03bcg\/kg (D1), dexmedetomidine 0.5 \u03bcg\/kg (D2), and normal saline (S). Hemodynamic variables include heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and peripheral blood oxygen saturation (Spo2) was measured and recorded before removing the endotracheal tube and at 1, 3, 5 and 10 minutes after extubation. Also, airway responses to extubation such as cough, hoarseness, and laryngospasm were investigated. Results: SBP, MAP, and HR in the D1 group were significantly lower than in other groups. In the D2 group, these measurements were lower than the control group at 3, 5, and 10 minutes after extubation (P<0.05 for all). In placebo group, SBP, MAP, and HR increased significantly after extubation (P=0.01). In group D1, cough (P=0.007) and its intensity (P=0.013), nausea and vomiting (P=0.04) and chills (P=0.001) were less than in other groups. Conclusion: In the D1 group, attenuation of autonomic response to extubation was more than other groups and side effects were less than D2 group, and in both groups, these side effects were less than the saline group.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260103251,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.34172\/jcvtr.2023.31647","PubMedCentral":"10466467","ArXiv":null},"license":"CCBY","url":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-15-73.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The development of advanced communication technologies emerged from the fourth industrial revolution has forced print media such as newspapers to evolve and adapt in the new digital media environment. The rise of online journalism for example, has radically impacted journalism profession in Malaysia particularly on how news is made. A fully digitized news content is the new frontier for 21st century journalism. The news industry landscape in Malaysia and other countries too have undergone similar significant changes and serious challenges as the news industry making the big leap into the age of digitization. Evidently, digital media, internet new media and so forth is here to stay. The adoption of the Internet by news organizations offers a new platform for reaching strategic mass audiences. The decentralization of media has enable audience to become highly selective when it comes to read any news. and to understand this has become a critical part in newsgathering and news-processing routines. The new media environment that characterized by its interactivity and flexibility provide the digital sanctuary for partisan bloggers and citizen reporters to thrive and creat their own version of news. Such phenomena presents a set of issues and opportunities that extend beyond traditional boundaries that is familiar to most journalists. As the Internet offers bigger storage, faster and expand in unpredictable directions, it raises an array of new questions about practices and values, some of which go to the declared defining essentials of journalism. With more and more people consuming news digitally, the future of journalism is constantly changing and journalists of the future will face a number of challenges. The results elaborate some of the tensions between traditional journalism, rooted in old media, and the new perceptions, expectations and pressures of digital journalism in an increasingly interconnected media system.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":158662011,"openaccessinfo":{"externalids":{"MAG":"2773743198","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Plants have been used as valuable sources of natural products for maintaining animal and human health.\u00a0The study investigated the phytochemical and antibacterial properties of the leaf extract of Mitracarpus scaber.\u00a0The antibacterial effect of Mitracarpus scaber extracts was done using Agar well diffusion method with Mueller\u00a0Hinton agar. Phytochemical composition of aqueous and ethanol extracts of Mitracarpus scaber leaves were\u00a0determined using Gas chromatography-mass spectrometry. The study revealed that the concentration of phenols\u00a0and tannins were more compared to other phytochemicals in both extracts when determined quantitatively. The\u00a0observed phenolic content was 19.34\u00b11.04 mg\/100 g and 44.48\u00b10.96 mg\/100 g for the aqueous and ethanolextracts respectively. While tannin content was 14.32\u00b11.04 mg\/100 g and 32.94\u00b11.28 mg\/100 g for the aqueous\u00a0and ethanol extracts respectively. Both extracts inhibited the growth of Escherichia coli (15\u00b12.00 mm and 23\u00b11.00\u00a0mm), Klebsiella oxytoca (17\u00b11.00 mm and 20 \u00b1 2.00 mm), Pseudomonas aeruginosa (13\u00b12.50 mm and 17\u00b11.00\u00a0mm), Proteus mirabilis (16\u00b11.00 mm and 22\u00b11.00 mm), Enterococcus faecalis (18\u00b11.00 mm and 24\u00b11.00 mm)\u00a0and Staphylococcus aureus (14\u00b12.00 mm and 21\u00b12.00 mm) at 100 mg\/ml. Gas Chromatography-Mass\u00a0Spectrometry confirmed the presence of 5-Nonanol (7.11%), 5-hydroxy-2-(hydroxyl methyl)- 4H-pyran-4-one\u00a0(6.17%), 2-octenoic acid (16.70%), 1-hydroxy-2,2,6,6-tetramethyl-3- (4-nitroso-1-(piperazinylmethyl)- piperidin-\u00a04-one (8.03%), Tetradecanoic acid (3.72%), Pentadecanoic acid (4.27%), 1, 2-Epoxyhexadecane (10.73%), Phytol\u00a0(1.61%) and 11-bromoundecanoic acid (32.91%) in the aqueous extract. While the ethanol extract contained 5-\u00a0Nonanol (29.71%), 5-hydroxy-2-(hydroxyl methyl)- 4H-pyran-4-one (24.95%), 2-octenoic acid (0.34%), 1-\u00a0hydroxy-2,2,6,6-tetramethyl-3- (4-nitroso-1-(piperazinylmethyl)- piperidin-4-one (12.72%), Pentadecanoic acid\u00a0(6.37%), 1, 2-epoxyhexadecane (0.07%), Phytol (2.53%), 6-octadecenoic acid (7.23%), 1,2-Benzenedicarboxylic\u00a0acid (8.60%) and 11-bromoundecanoic acid (1.10%). The results of this study revealed that Mitracarpus scaberleaves possesses antimicrobial effects.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":229538001,"openaccessinfo":{"externalids":{"MAG":"3107017499","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The field of e-learning has emerged as a topic of interest in academia due to the increased ease of accessing the Internet using using smart-phones and wireless devices. One of the challenges facing e-learning platforms is how to keep students motivated and engaged. Moreover, it is also crucial to identify the students that might need help in order to make sure their academic performance doesn't suffer. To that end, this paper tries to investigate the relationship between student engagement and their academic performance. Apriori association rules algorithm is used to derive a set of rules that relate student engagement to academic performance. Experimental results' analysis done using confidence and lift metrics show that a positive correlation exists between students' engagement level and their academic performance in a blended e-learning environment. In particular, it is shown that higher engagement often leads to better academic performance. This cements the previous work that linked engagement and academic performance in traditional classrooms.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":52149154,"openaccessinfo":{"externalids":{"MAG":"3119042572","ACL":null,"DOI":"10.1109\/EDUNINE.2018.8451005","PubMedCentral":null,"ArXiv":"2101.02006"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The thesis work I determined and compared the team work in kindergarten and school. I was interested in cooperation between a preschool teacher and an assistant preschool teacher and a primary school teacher and a preschool teacher at school. The participants and members of the team directly share roles and they are equivalent to each other. However, it is necessary to emphasize their difference in knowledge, skills and abilities. They do not have the same level of competence, motivation and work habits. Mutual cooperation and closeness and good communicational skills are necessary factors of successful team work. Team work consists of three stages: team planning, team teaching and team evaluation. In kindergarten the team work has been running for a very long time, but preschool teachers and assistant preschool teachers had different and separate tasks in the past. The introduction of the kindergarten curriculum has changed these tasks. They should jointly plan, implement and evaluate the activities. By changing education legislation in Slovenian primary schools there has also been a change in the mode of teaching. In the first grade the team work is conducted by a primary school teacher and a preschool teacher, as the second professional worker. In the theoretical part of my diploma work I define the team work, describe its special features and compare the team work between the kindergarten and school. The purpose of the study is to analyze the characteristics of the team work in kindergarten and school and compare them with each other. I was particularly interested in the team work between the preschool teacher and assistant preschool teacher in kindergarten and teamwork between the primary school teacher and the preschool teacher at school. I also presented how teams work in both environments. The main aim of my study is to examine: the organization of team work and its participants in kindergarten and school, the implementation of the three stages of team work, the complementation of each other, the division of tasks and their participation with parents. I wrote about formal equality and feelings of equivalence by the members, advantages and disadvantages of team work recognized at their work. I developed a questionnaire based on the theoretical points and set of research questions. In my research I have included 100 preschool teachers and assistant preschool teachers employed in Slovenian kindergartens and 100 primary school teachers and preschool teachers in the 1st grade of Slovenian primary schools.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":141840890,"openaccessinfo":{"externalids":{"MAG":"592079586","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effect of confluent monolayers of density-inhibited (A31-714, 10T\u00bd, and Hepano) and transformed (SEA-7, HSV-2-5, and HT2B-1) cells on the proliferation of superinoculated cells was examined. Most monolayers were lethally irradiated. The growth of density-inhibited cells was inhibited when they were inoculated on a monolayer of homologous cells. In contrast the growth pattern of transformed cells on a homologous cell sheet was not different from that on an empty plate. The growth capacity of density-inhibited cells on a monolayer of heterologous density-inhibited cells was as follows: ( a ) the growth of A31-714 cells was inhibited by neither 10T\u00bd nor Hepano cells; ( b ) 10T\u00bd cells proliferated well on Hepano cells but not on A31-714 cells; ( c ) the growth of Hepano cells was inhibited by both A31-714 and 10T\u00bd cells; ( d ) densityinhibited cells were able to proliferate on top of homologous cells once the basal cell layer was fixed with either glutaraldehyde or osmic acid; ( e ) the effect of a monolayer of two types of transformed cells on superinoculated density-inhibited cells was also tested. HSV-2-5 cells restricted the growth of density-inhibited cells, but SEA-7 cells did not.\n\nThese growth-regulatory effects do not seem to be mediated by soluble substances released into the culture medium by cells.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":407705,"openaccessinfo":{"externalids":{"MAG":"1877809683","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An increase in distal nephron-dependent sodium (Na+) reabsorption plays a primary role in the development of obesity-induced hypertension. However, the specific Na+ transporter involved in this process is unknown. The present studies were undertaken to determine the role of the epithelial Na+ channel (ENaC) in the development of high fat-diet (HFD)-induced hypertension. Given that human obesity-induced hypertension is largely salt-sensitive, we chose to expose Dahl salt-sensitive (DSS) rats to either a chronic HFD (42% kcal from fat, normal salt, 0.25%, N=7)) or standard diet (STD, 10% kcal from fat, normal salt, 0.25%, N=7), measure blood pressures (BP) telemetrically, and collect 24 hr urine for Na+ each week, for 4 weeks. In a separate group of DSS rats, we isolated cortical collecting ducts for determination of \u03b1ENaC protein expression at baseline, 1 week, and 4 weeks following STD or HFD. Telemetric systolic blood pressure (SBP) values increased significantly (P<0.05) from a baseline value of 118\u00b12.7 mmHg to 135\u00b14.4 mmHg after just 2 weeks on the HFD, and to 146.9\u00b12.6 mmHg after 4 weeks (P<0.01). SBPs did not change in DSS rats on STD for the entire 4 weeks. Prior to the increase in BP, 24 hr urine Na+ excretion significantly decreased in DSS rats on HFD compared to STD (0.94\u00b10.15 \u03bcmol\/min vs. 1.35\u00b10.09, P<0.05). Furthermore, compared to baseline, \u03b1ENaC protein levels significantly increased after 1 week of HFD [0.93\u00b10.13 and 0.51\u00b10.02 densitometric units (DU) respectively, P<0.01], but not after 1 week of STD (0.46\u00b10.02 DU). Following 4 weeks of HFD, \u03b1ENaC protein levels remained significantly elevated (0.66\u00b10.05 DU; P<0.05) compared to baseline. These results suggest that increased cortical collecting duct \u03b1ENaC protein expression may contribute to the reduction in Na+ excretion that initiates the hypertensive cascade in HFD-induced hypertension.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":74597619,"openaccessinfo":{"externalids":{"MAG":"2230685537","ACL":null,"DOI":"10.1161\/hyp.60.suppl_1.a624","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A minimax approach for multi-objective controller design is proposed, in which structured uncertainty is characterized by multiple discrete-time SISO models. Typical engineering objectives are optimized for all models, such as bounds on different sensitivity functions and time-domain responses. The approach is illustrated by improving the best performing controller of a flexible arm benchmark example.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":123438252,"openaccessinfo":{"externalids":{"MAG":"2167438706","ACL":null,"DOI":"10.1080\/002071799220885","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The injuries of abdominal cavity organs are analyzed in 1158 injured persons with isolated and concomitant trauma. It is established that the injury frequency of parenchymatous organs is two times more then of cavitial.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37603631,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as \"architectural transcriptional factors\". By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulating gene expression by either enhancing or suppressing the binding of the more usual transcriptional activators and repressors, although they do not themselves have any transcriptional activity. Their involvement in both benign and malignant neoplasias is well-known and supported by a large volume of studies. In this review, we focus on the role of the HMGA proteins in hematological malignancies, exploring the mechanisms through which they enhance neoplastic transformation and how this knowledge could be exploited to devise tailored therapeutic strategies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219398990,"openaccessinfo":{"externalids":{"MAG":"3033729667","ACL":null,"DOI":"10.3390\/cancers12061456","PubMedCentral":"7353061","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6694\/12\/6\/1456\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Cardiac troponin molecules (cTnI and cTnT) are the most valuable and in-demand biomarkers for detecting various types of myocardial damage (reversible and irreversible, ischemic, inflammatory, toxic, etc.) in current clinical practice. These biomarkers are widely used for early diagnosis of acute myocardial infarction (AMI) and risk stratification of patients suffering from a number of cardiac (such as myocarditis, heart failure, cardiomyopathy, etc.) and extra-cardiac diseases (such as sepsis, renal failure, pulmonary embolism, neurological pathologies, etc.) that negatively affect the cells of cardiac muscle tissue. However, in daily routine clinical activities, internists and cardiologists often encounter cases of false increases in the concentrations of cardiospecific troponins. A false increase in the concentration of troponins contributes to an incorrect diagnosis and incorrect therapy, which can harm the patient. A false increase in the concentration of troponins contributes to an incorrect diagnosis and incorrect therapy, which can harm the patient, therefore, internists and cardiologists should be well aware of the main reasons and mechanisms of false positive results of cTnI and cTnT. This review article mainly focuses on the causes of false positive increases in serum levels of cTnI and cTnT, which provide helpful clues for the accuate diagnosis of AMI and evidence for the differential diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248180354,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2174\/1573403X18666220413124038","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A pair of Mw = 5.5 earthquakes occurred beneath the Brooks Peninsula on the northwest coast of Vancouver Island on 2 June and 25 July 1978. These are the largest and best-recorded earthquakes to date in the vicinity of northern Vancouver Island and the adjacent coast margin. A detailed study of these earthquakes was undertaken to examine the contemporary tectonics of this region, specifically the poorly understood interaction between the Explorer plate and the North American plate at the northern end of the Cascadia subduction zone. Both earthquakes were followed by well-defined aftershock sequences. A four-station temporary seismograph array deployed on the Brooks Peninsula following the 2 June mainshock allowed for accurate aftershock locations. This earthquake was located at 50.15\u00b0 N, 127.84\u00b0 W, based on the center of a 9-km-diameter circular region of aftershocks. The 25 July earthquake was located 4 to 7 km to the northeast of the June epicenter based on waveform comparison of the two events. Both earthquakes occurred at 15 to 16 km depth. The focal mechanisms as determined from body-wave modeling are nearly identical and show left-lateral strike-slip motion along a shallow north-dipping, east-west-striking fault. The focal mechanism and depth of these two earthquakes indicates that they were not megathrust events on the Explorer\/North America plate boundary, but rather that they occurred within the North American plate, 5 to 10 km above the megathrust. The northeast-directed pressure axes for these earthquakes suggests coupling across the Explorer-North America segment of the Cascadia subduction zone, consistent with contemporary convergence of the Explorer Plate with the North American plate in a northeast-southwest direction.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":130231829,"openaccessinfo":{"externalids":{"MAG":"2300138214","ACL":null,"DOI":"10.1785\/bssa0870041011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Efficient use of the limited radio spectrum is of paramount importance to supporting the ever-increasing number of mobile terminals. There is a need for devising complementing techniques to improve the performance of dynamic channel-assignment (DCA) algorithms to increase the capacity of cellular systems. In this paper, we study the concept of call-on-hold to improve the performance of a class of DCA algorithms called coordinated assignment without measurement (CAWM). DCA algorithms such as the Geometric strategy, the Nanda-Goodman strategy, the borrowing with directional channel locking (BDCL) strategy, and the two-step dynamic priority (TSDP) strategy fall into the CAWM class. To gain insight into the CAWM DCA algorithms, we simulated those algorithms and monitored carrier availability and failure to assign a channel characteristics in a cell. After observing these characteristics, we formulated a hypothesis as follows: If a new or handoff call is put on hold for a short while in a cell in the absence of an available channel, it is highly likely that the local base station will soon find a channel for the call. In the proposed approach, a DCA algorithm is said to have failed to assign a channel to a call only if a waiting call is delayed for longer than a threshold period called maximum delay. Our simulation-based study shows that it is possible to significantly reduce failure rates of the CAWM class of DCA algorithms by putting those calls on hold which would otherwise be blocked or dropped. The impact of small values of maximum delay on the average delay suffered by all calls in a network is negligible, but the reduction in failure rate is significant. We have explained how the call-on-hold idea can be easily integrated with the GSM system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":27029881,"openaccessinfo":{"externalids":{"MAG":"2167722672","ACL":null,"DOI":"10.1109\/TVT.2004.836961","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider the problem of characterizing Bayesian networks up to unconditional equivalence, i.e., when directed acyclic graphs (DAGs) have the same set of unconditional $d$-separation statements. Each unconditional equivalence class (UEC) is uniquely represented with an undirected graph whose clique structure encodes the members of the class. Via this structure, we provide a transformational characterization of unconditional equivalence; i.e., we show that two DAGs are in the same UEC if and only if one can be transformed into the other via a finite sequence of specified moves. We also extend this characterization to the essential graphs representing the Markov equivalence classes (MECs) in the UEC. UECs partition the space of MECs and are easily estimable from marginal independence tests. Thus, a characterization of unconditional equivalence has applications in methods that involve searching the space of MECs of Bayesian networks.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":251280637,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2203.00521"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two novel species, trichloromethanesulfenyl acetate, CCl(3)SOC(O)CH(3), and trichloromethanesulfenyl trifluoroacetate, CCl(3)SOC(O)CF(3), have been generated in situ by the heterogeneous reactions between trichloromethanesulfenyl chloride, CCl(3)SCl, and corresponding silver salts, silver acetate (AgOC(O)CH(3)) and silver trifluoroacetate (AgOC(O)CF(3)), respectively. Photoelectron spectroscopy and quantum chemical calculations are performed to investigate these two molecules, together with their precursor, CCl(3)SCl. Both of these two compounds may exist in the gas phase as a mixture of gauche and trans conformations. As for the dihedral angles delta(RSOR') of the gauche conformers, 107.0 degrees and 108.5 degrees are derived by theoretical calculations (at the B3LYP\/6-311+G(3df) level) for CCl(3)SOC(O)CH(3) and CCl(3)SOC(O)CF(3), respectively. The first vertical ionization energies of CCl(3)SOC(O)CH(3) and CCl(3)SOC(O)CF(3), which have been determined by photoelectron spectroscopy, are 9.67 and 10.34 eV, respectively. According to the experimental results and theoretical analysis, the first ionization energy of these two molecules both come from the ionization of the lone pair electron of S atom.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45192119,"openaccessinfo":{"externalids":{"MAG":"2087188861","ACL":null,"DOI":"10.1021\/JP070601D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo evaluate the pattern of tumour infiltrating lymphocytes in colorectal cancers, and to correlate them with nuclear protein Ki67, vascular endothelial growth factor and clinical outcome.\n\n\nMETHODS\nThe retrospective study was conducted at the Nuclear Institute of Medicine and Radiotherapy and the Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan, and comprised data of colorectal cancer patients from January 1, 2008, to December 31, 2018. Whole tumour sections of colorectal cancer were used with haematoxylin and eosin staining, Histological type, grade and infiltrated lymphocytes within the tumour block were assessed. Ki67 and vascular endothelial growth factor were evaluated by immunohistochemistry, while the staining of these biomarkers was assessed by the percentage of cells stained. Data was analysed using SPSS 22.\n\n\nRESULTS\nOf the 201 patients, 110(54.7%) were males and 91(45.3%) were females. Overall median age was 43 years (range 10-85 years). Majority of the tumours 132(65.7%) showed mild to moderate tumour infiltrating lymphocytes, 30(14.9%) had severe tumour infiltrating lymphocytes, while 39(19.4%) did not show any infiltrating lymphocytes. Tumour infiltrating lymphocytes did not show significant association with the histological grade (p>0.05), but high tumour infiltrating lymphocytes were associated with poor survival without being significantly associated with Ki67 pattern and vascular endothelial growth factor (p>0.05).\n\n\nCONCLUSIONS\nMajority of colorectal cancer cases showed varying levels of lymphocyte infilteration, and tumour infiltrating lymphocytes were associated with poor survival, without having significant association with Ki67 pattern and vascular endothelial growth factor.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":251656308,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.47391\/jpma.4363","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.47391\/jpma.4363","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Transport measurements were performed on the organic layered compound \\aI3 under hydrostatic pressure. The carrier types, densities and mobilities are determined from the magneto-conductance of \\aI3 . While evidence of high-mobility massless Dirac carriers has already been given, we report here, their coexistence with low-mobility massive holes. This coexistence seems robust as it has been found up to the highest studied pressure. Our results are in agreement with recent DFT calculations of the band structure of this system under hydrostatic pressure. A comparison with graphene Dirac carriers has also been done.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":118426381,"openaccessinfo":{"externalids":{"MAG":"1510906096","ACL":null,"DOI":"10.1103\/PhysRevB.87.245110","PubMedCentral":null,"ArXiv":"1306.4105"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using electron spin resonance (ESR) technique we have obtained data evidencing the existence of magnetic vortices in high-temperature superconductors at temperatures above the critical one $T_c$. We have studied magnetic excitations in \\bis single crystals above $T_c$ with the method of surface spin decoration. The surface layer of diphenyl-picrylhydrazyl was used as a sensitive probe of magnetic field distortions. The temperature dependence of the ESR signal parameters has indicated that far above $T_c$ the magnetic flux of a sample is affected by the superconducting order parameter fluctuations while close to $T_c$ its changes are due to vortex-type excitations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264964516,"openaccessinfo":{"externalids":{"MAG":"1662637453","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Context\nThe paper reports a case of trauma treated by the Move to Emptiness Technique (MET), which is a therapy to alleviate patient's physical or psychological symptom related to trauma by combining Qigong with imagery, metaphor and suggestions.\n\n\nObjective\nTo introduce MET and report treating a patient with trauma using MET.\n\n\nIntervention\nThe patient was guided to visualize a symbolic object that represented the physical or psychological symptom of the traumatic experience, and visualize moving the symbolic object to the farthest possible space of \"emptiness\", where the object became imperceptible. At the same time, the patient embodied the physical and emotional sensations of the symbolic object and its container, and focused on the changes in his sensations when moving them.\n\n\nOutcome Measures\nA self-assessment was used to score the patient's distress form 0 to 10, 10 being the worst before and after intervention.\n\n\nResults\nThe score of distress dropped form 8\/10 to 2\/10. The patient improved a lot and was better able to manage his emotions and communicate with his parents after resolving his conflict.\n\n\nConclusions\nMET may be an alternative to commonly used trauma-focused treatments. It is safe and easy to learn for therapists and patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":242940594,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This review article surveys recent work on time and temporality in international relations. It begins with an overview of Kimberly Hutchings's influential history of ideas exploring the relationship between chronos (quantitative experience of time) and kairos (qualitative conceptualisation of time). Building on the architecture of Hutchings's argument, it surveys more recent scholarship that supplements, extends and complicates her insights in two ways. First, while Hutchings focuses on the way in which theorisations of kairos shift over time, the development of a unified global chronotic imaginary was itself a contested process, frequently interrupted by kairotic considerations. Second, while Hutchings is interested in western conceptualisations of kairos, recent work has shifted the analytical focus to those subject positions marginalised by such kairotic imaginaries.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":150208657,"openaccessinfo":{"externalids":{"MAG":"2898808377","ACL":null,"DOI":"10.1177\/0305829818801494","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/eprints.soas.ac.uk\/29913\/1\/Rao%20review%20article%20One%20Time%20Many%20Times.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Objective: Therefore the aim of this work is the analysis of different MAP estimation methods and its impact on derived aSBP values. Methods: In a series of eight patients we retrospectively compared aSBP as assessed with the Complior\u00ae device with aSBP provided with a validated oscillometric device using a generalized transfer function (ARCSolver\u00ae, Mobil-O-Graph\u00ae). aSBP was determined for clinical indications in patients (age: 64+9.9, sex:2 female, 6 male)with arterial hypertension or coronary artery disease. In the case of the Complior\u00ae device the wave form calibration was based on determination of calculated mean pressure (MAP1) and diastolic pressures as assessed with a validated oscillometric device. In the case of the Mobil-O-Graph\u00ae measured mean (MAP2) and diastolic pressures were used for wave form calibration. Furthermore, measured mean and diastolic pressures of the Mobil-O-Graph\u00ae were used for assessment of aSBP in the Complior\u00ae device. Design and method: As expected peripheral values of SBP and DBP where the same for both oscillometric devices (128+ 8.7\/77.5+12.7 mmHg vs 127.9+7.0\/78.1+12.5 mmHg; ns). Nevertheless as depicted in the figure striking differences for aSBP were observed between the Complior\u00ae device and the Mobil-O-Graph\u00ae (99.4+11.0 vs 139.3+8.4 mmHg; p\u200a=\u200a0,000017) depending on the calibration. Simliarly as shown in the figure we observed a difference of 15 mmHg for the two oscillometric devices between MAP1 and MAP2 (86.3+ 9.9 vs 101.0+ 8.3 mmHg,; p\u200a=\u200a0,00006). If we used the measured mean (MAP2) and diastolic pressures of the Mobil-O-Graph\u00ae for calibration of the Complior\u00ae device as well the differences for aSBP diminished significantly (133.7+ 10.6 vs 139.3 +8.4mmHg for Complior\u00ae and Mobil-O-Graph\u00ae respectively; ns). Results: The assessment on aSBP critically affects absolute aSBP values reported to the physician. If the same calibration method is used, different results between devices diminish. With respect to clinical practice and thresholds standardization of MAP definition is indicated.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":78756309,"openaccessinfo":{"externalids":{"MAG":"2499226844","ACL":null,"DOI":"10.1097\/01.hjh.0000492398.09036.16","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Previous studies on biased intergroup perceptions of outgroups' irrationality mostly treated the target groups as opponents and rivals. In three studies, we extended this line of research and tested the hypothesis that individuals who challenge the existing social hierarchy exhibit more positive biases toward low-status outgroup members. We also hypothesized that when irrational thinking is framed as an important human trait, this bias is reduced among low social dominance orientation (SDO) individuals. In three studies (N = 169, N = 450, and N = 161), conducted in countries that vary in power distance levels (Poland, Spain, Sweden and Turkey), we examined under which conditions low-status outgroups are perceived as more rational than ingroup members. The results show that in a condition without irrationality framed as a human trait, psychology students (Study 1 and Study 2) and nonstudents low in group-based dominance orientation (Study 3) perceive outgroup members as less irrational than ingroup members. However, when participants were reminded that irrationality is a human trait, the perceived differences between in- and outgroup members were reduced. This effect was observed in all four countries (Study 1 and Study 2) and held when variables related to the tendency to behave in a socially desirable way were controlled for (Study 3).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":150674564,"openaccessinfo":{"externalids":{"MAG":"2920526465","ACL":null,"DOI":"10.5964\/JSPP.V7I1.951","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. The incorporation of vapor transport has become a key demand for snowpack modeling where accompanied phase changes give rise to a new, non-linear coupling in the heat and mass equations. This coupling has an impact on choosing efficient numerical schemes for one-dimensional snowpack models which are naturally not designed to cope with mathematical particularities of arbitrary, non-linear PDE's. To explore this coupling we have implemented a stand-alone finite element solution of the coupled heat and mass equations in snow using FEniCS. We solely focus on the non-linear feedback of the ice phase exchanging mass with a diffusing vapor phase with concurrent heat transport in the absence of settling. We demonstrate that different, existing continuum-mechanical models derived through homogenization or mixture theory yield similar results for homogeneous snowpacks of constant density. For heterogeneous situations in which the snow density varies significantly with depth, we show that phase changes in the presence of temperature gradients give rise to a non-linear advection of the ice phase that amplifies existing density variations. Eventually, this advection triggers a wave instability in the continuity equations. This is traced back to the density dependence of the effective transport coefficients as revealed by a linear stability analysis of the non-linear PDE system. The instability is an inherent feature of existing continuum models and predicts, as a side product, the formation of a low density (mechanical) weak layer on the sublimating side of an ice crust. The wave instability constitutes a key challenge for a faithful treatment of solid-vapor mass conservation between layers, which is discussed in view of the underlying homogenization schemes and their numerical solutions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233747536,"openaccessinfo":{"externalids":{"MAG":"3155398793","ACL":null,"DOI":"10.5194\/TC-2021-72","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In recent years, several experimental studies have shed new light on possible faulting mechanisms responsible for intermediate and deep-seated earthquakes. These studies rely not only on the traditional analysis of mechanical data and recovered microstructures, but also on the in situ collection of acoustic data \u2013in the form of Acoustic Emissions (AEs)\u2013 used to identify possible co-seismic faulting, i.e., brittle failure. I will give an overview of this recent work and detail how, recently, deep-focus earthquakes mechanisms could be investigated at 1.5 GPa and 750-900\u00b0C, in a new-generation Griggs-type apparatus using sintered Mg 2 GeO 4 samples. This compound is an analogue of natural olivine for which the transition towards the high pressure phase (spinel structure) occurs at atmospheric pressure, instead of ~14 GPa for the silicate. This transition induces a mechanical instability \u2013the so-called transformational faulting\u2013 that leads to macroscopic failure of the samples in a narrow temperature window. The boundaries of this brittle window, as for other reactions (quartz-coesite, antigorite dehydration, plagioclase breakdown and so on), are defined by the reaction kinetics. Here, faulting only occurs in cases where spinel nucleates but hardly grows, i.e., when reaction rates are slow. At 900\u00b0C mechanical data show a softening, indicative of ductile plastic flow, whereas large amounts of hardening followed by rapid stress drops (and audible stick slips) are recorded at 750\u00b0C. AEs were detected in both cases and differences between P and S waves arrival times suggest that the majority of AEs originate inside the sample. Coherence analysis of the AEs seems to suggest that some bursts of events have similar sources. Surprisingly, AEs are more numerous (~600) at higher temperature, where deformation takes place in a ductile way, accommodated by the development of a wide mylonitic shear band. However, at 750\u00b0C, far more energy is released acoustically upon brittle faulting despite a lower number of AEs (~100). Therefore, higher temperatures favor larger reaction rates, which, in turn, allow the growth of ductile fine-grained spinel. Our results confirm that the brittle temperature window (1) is a function of both equilibrium overstep (reaction kinetic) and strain rate and (2) seems to shift towards lower temperatures with decreasing strain rates, which may explain how earthquakes can occur in a slowly reacting metastable olivine wedge at strain rates orders of magnitude lower than in the lab.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":213308376,"openaccessinfo":{"externalids":{"MAG":"2998594215","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The period 1914\u20131918 was tumultuous in Ireland when conflict wrought by international tensions was exacerbated by a fractious domestic political scene that ultimately resulted in partition of the island into two jurisdictions: Northern Ireland, comprised of six of the nine Ulster counties, and the Free State, encompassing the remaining twenty-six counties. Both were dominions within the British Commonwealth with domestic parliaments controlling internal affairs. Neither were the desired political outcome of the various factions who had protested, taken up arms, and eventually negotiated. Women were pivotal on both sides of the political divide. For those who wished to stay in the union with Great Britain, the First World War was a chance to demonstrate loyalty and to showcase the particular contributions of women, from hosting Belgian refugees to the encouragement of enlistment of husbands, sons and friends. For those who wished to see the enactment of independence for Ireland, as promised in the 1912 Home Rule Bill and the suspended Act of 1914, the First World War provided an opportunity to enact long-held ambitions for a violent revolution, with women participating in active combat and non-combatant roles. Thus while the First World War was a pivotal moment for women globally, in Ireland it had an additional layer of complexity given the national political context. This article seeks to explore these intersections and tensions, providing an introduction to this special issue in which many facets of the war period in Ireland are explored.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152268862,"openaccessinfo":{"externalids":{"MAG":"2585926877","ACL":null,"DOI":"10.1080\/09612025.2016.1223311","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/mural.maynoothuniversity.ie\/11762\/1\/Redmond_War_2017.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Mesna (Mistabron) is a mucolytic substance that is also used for chemically assisted dissection during cholesteatoma surgery. The present animal study aims to evaluate its possible ototoxic side effects. To this end, the right tympanic cavity of 9 guinea pigs was filled with either 20% mesna or 10% neomycin (serving as a positive control), while the left tympanic cavity was filled with saline (serving as a negative control). One week after administration, the inner ears were dissected out and further processed for morphological evaluation by means of either interference contrast microscopy or scanning electron microscopy. No macroscopic signs of middle ear inflammation were observed in any of the ears treated. Whereas damage was obvious in all neomycin-treated specimens, the morphology of both saline- and mesna-treated inner ears was unaffected. These findings led us to conclude that, at least on a morphological basis, no indications are at hand to assume ototoxic effects of this mucolytic substance due to a single application during cholesteatoma surgery.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33232081,"openaccessinfo":{"externalids":{"MAG":"2133943477","ACL":null,"DOI":"10.1080\/00016489950180630","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"For conceptual design of electromechanical motion systems, an assessment method is formulated that supports the design of a feasible reference path generator, control system, and electromechanical plant with appropriate sensor locations, in an integrated way. This method is based on a classification of standard transfer functions, plant models, and closed-loop systems. The assessment method can be applied in several ways, depending on the available knowledge about the design problem. In order to illustrate this method, an application to an industrial motion system is described. The assessment method quickly provides insight in the design problem. Furthermore, feasible goals and required design efforts can be estimated at an early stage.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":17930348,"openaccessinfo":{"externalids":{"MAG":"2108098964","ACL":null,"DOI":"10.1109\/TMECH.2002.803630","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Comparing and searching protein structures independent of primary sequence has proved useful for remote homology detection, function annotation and protein classification. With the recent leap in accuracy of protein structure prediction methods and increased availability of protein models, attention is turning to how to best make use of this data. Fast and accurate methods to search databases of millions of structures will be essential to this endeavour, in the same way that fast protein sequence searching underpins much of bioinformatics. We train a simple graph neural network using supervised contrastive learning to learn a low-dimensional embedding of protein structure. The embedding can be used to search structures against large structural databases with accuracy comparable to current methods. The speed of the method and ability to scale to millions of structures makes it suitable for this structure-rich era. The method, called Progres, is available at https:\/\/github.com\/jgreener64\/progres.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":254097617,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2022.11.28.518224","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2022\/11\/28\/2022.11.28.518224.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Agency cost is an internal cost which arises between management (agent) and shareholder (principal), because of the diverging interest of the two parties. Dividend payments are often employed to mitigate this cost. Studies have examined the effect of dividend pay-outs on agency costs documenting mixed findings. However, the literature on the reverse effect of agency costs on dividend pay-outs is still nascent. The main objective of the study is to examine the effect of agency cost on dividend pay-out of listed manufacturing firms in Nigeria. The study used a panel research design. The population of the study comprised listed manufacturing firms, but delimited to firms in conglomerate and consumer goods sectors of the Nigerian Stock Exchange. Data for the study were collected from yearly financial statements of the selected firms. The hypotheses were tested using pooled OLS Regression. The dependent variable of the study was dividend pay-out, while assets to sales ratio, leverage, and free cash flow were proxies of agency cost. Firm size and profitability measures (ROA and ROE) were used as control variables in the study. The study found a significant and positive effect of assets to sales ratio and free cash flow, and a significant and negative effect of leverage on dividend pay-out. The study recommended amongst others that, managers should consider the implication of agency costs in the design of in the design and implementation of a dividend policy.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":169114511,"openaccessinfo":{"externalids":{"MAG":"2892046145","ACL":null,"DOI":"10.32455\/IJMBE.V1I1.40","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An efficient method for representing multivalued functions is described. The method employs an algorithm which generates an efficient cover for a given function \"directly,\" i.e., without resorting to the intermediate step of creating a table of prime implicants. Data are presented to show that the covers generated are as efficient in terms of cover size as prime implicant based methods. More importantly, however, the direct cover method is shown to require much less computation time than prime implicant based methods, thus making it practical for functions with a large number of input variables and\/or as the radix of implementation increases. The algorithm is introduced by applying it to functional representations employing the traditional max and min operation. Next, a modified form of the algorithm is presented for use with the sum and product operators more appropriate to I2L and other current summation technologies.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":922494,"openaccessinfo":{"externalids":{"MAG":"2061510426","ACL":null,"DOI":"10.1109\/TC.1981.1675867","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Swamp taro is gaining importance as a non conventional starchy vegetable in some parts of Eastern India and Bangladesh during monsoon months when traditional vegetables become scarce in the market. Although, a large number of indigenous germplasms of swamp taro are grown in India, detailed information on all aspects of the morphological, biometrical, nutritional and anti-nutritional status of the crop is very meager. Furthermore, no recognized variety has so far been developed in India. Therefore, this study was undertaken to identify the potential types of swamp taro. Forty-four diverse landraces of swamp taro were evaluated in a randomized block design with three replications at the Horticultural Research Station, Bidhan Chandra Krishi Viswavidyalaya, Mondouri, Nadia, West Bengal, India as a part of the programme for characterization of germplasms under the All India Coordinated Research Project on Tuber Crops. The germplasms of swamp taro showed marked variation in morphological characters, stolon yield (8.2-34.7 t\/ha), its attributes like stolon length (0.65-1.45 m), stolon girth (0.95-2.55 cm), number of stolon \/plant (10-23), and nutritional parameters like dry matter (11.2-16.4), starch (3.2-8.1 %), total sugar (0.63-2.68 %), protein (0.49-1.17 %) and vitamin C (15.34-61.72 mg\/100 g) content of the stolons. There was considerable variability in mineral composition of the stolons also among different germplasms of swamp taro and they appeared to be good sources of potassium, calcium, iron, copper and manganese among the members of edible aroids. Among forty-four landraces of Indian swamp taro, ten accessions namely BCST-1, BCST-3, BCST-5, BCST-13, BCST-14, BCST-21, BCST-29, BCST-36, BCST-42, BCST-44 performed better and were considered as the most promising genotypes, having higher yield, low disease incidence and better nutritional quality with slight or no acridity. These deserve greater attention for a further breeding programme to identify commercial cultivars.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":89327734,"openaccessinfo":{"externalids":{"MAG":"2558487417","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To the Editor: We read with interest the article by Tarim et al. (1) who investigated the prevalence of hyperhomocysteinemia in Turkish women with gestational diabetes. These authors stated that plasma homocysteine levels are increased in gestational diabetes. However, we think this study has two important weak points. First, the mean maternal age in the group of women with gestational diabetes mellitus (Group 3) was 32 4.03 years, which was significantly higher than the mean maternal age of the two other groups consisting of women with abnormal 50-g oral glucose test but normal 3-hr oral glucose and women with normal 50-g oral glucose test (28.88 4.68 and 26.83 4.44 years, respectively). The women with abnormal glucose-tolerance test and obvious gestational diabetes were also older than those who were glucose tolerant. As there is evidence that plasma homocysteine levels do increase with maternal age, these data should be interpreted with caution (2\u20134). The second point is that the body mass index is markedly different between women with gestational diabetes and normal controls. Again, it has been previously reported that plasma homocysteine levels tend to be higher in obese women compared with non-obese controls (5). On the basis of these grounds, plasma homocysteine levels should only be compared in ageand body mass indexmatched cohorts. This would lead us to clear results and prevent bias. Melih Atahan Guven Ali Cetinkaya","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38707135,"openaccessinfo":{"externalids":{"MAG":"2616332634","ACL":null,"DOI":"10.1111\/j.0001-6349.2005.0719a.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The paper presents the results of the development and implementation of a method for controlling technological processes of locomotive repair based on network planning, which allows monitoring and adjusting the performance of technological operations for a specific locomotive, taking into account the provision of indicators of technological preparation of repair.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234451600,"openaccessinfo":{"externalids":{"MAG":"3116416629","ACL":null,"DOI":"10.1051\/e3sconf\/202022403027","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.e3s-conferences.org\/articles\/e3sconf\/pdf\/2020\/84\/e3sconf_TPACEE2020_03027.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0Shear-induced brittle fractures in vesicular magmas are thought to be possible pathways for open-system degassing that controls the explosivity of volcanic eruptions. To investigate the detailed processes involved in the shear-induced degassing, we performed torsional deformation experiments on columnar rhyolites with water contents and averaged vesicularities of 0.4\u20130.5 wt % and 20\u201341 vol %, respectively, at temperatures of 780\u2013930\u00b0C and strain rates of <0.03 s\u22121. The experimental conditions, such as viscosity and vesicularity of the sample, strain rate, and total strain, simulated those of typical natural dehydrated rhyolites in shallow volcanic conduits. At relatively high temperatures (\u2265855\u00b0C), the columnar samples were homogeneously twisted and deformed. On the other hand, at temperatures of \u2264830\u00b0C, the deformation was localized and finally resulted in brittle failure into a column and a disk, followed by a slip at the fractured interface. This slip prevented further brittle failure and shear-induced bubble coalescence in the remaining parts of the sample. A permeable fragmented zone was formed near the interface, while in the rest of the sample, the bubbles remained isolated and permeability did not increase. From this, we infer that a single event of magma fracturing may enhance open-system degassing locally near a fracture, but repeated fracturing and healing processes are necessary for the effective degassing of the entire magma that leads to nonexplosive eruptions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129373751,"openaccessinfo":{"externalids":{"MAG":"2030328711","ACL":null,"DOI":"10.1029\/2009JB006904","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Preterm birth is the leading cause of perinatal morbidity and mortality in otherwise healthy infants, and the rate of pregnancies complicated by a premature delivery continues to rise. Subsequently, attempts have been made to reduce this rate by using progesterone supplementation during pregnancy. 17alpha-Hydroxyprogesterone caproate (17P), a metabolite of progesterone, also has been used as supplementation during pregnancy to prevent preterm births. We report a case of iatrogenic autoimmune progesterone dermatitis (APD) in a pregnant woman who received 17P therapy. Due to the increased use of 17P, our case could represent an increasingly prevalent entity that dermatologists and obstetricians should recognize. In this article, we discuss our findings and provide a basic review of APD.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2013-20":1,"unknown":2}},"corpusid":43815696,"openaccessinfo":{"externalids":{"MAG":"1847795804","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The response time of hydrological components is an important feature for establishing the connections within a hydrological system and for characterizing it. This study proposes a quantitative and qualitative assessment on the response times of river discharge components, especially the baseflow, regarding the impulse provided by precipitation, using time series analyses of time and frequency domains. To this end, a set of complementary methods including correlation and spectral approaches was used, which are: autocorrelation, cross correlation, continuous wavelet transform, and cross wavelet transform. Such framework was applied in multiple and nested basin scales (53, 1,867, and 3,519 km2), located in the Jacar\u00e9\u2010Gua\u00e7u River Basin (Southeastern Brazil). Based on a digital filtering technique, it was found the baseflow contributes more than 80% of the annual streamflow, revealing a major role of the aquifer in regulating the river discharge in all three studied basins. In addition, we found baseflow represents a range of 24%\u201327% of the annual precipitation. The uniform results are mainly due to the similar physical characteristics found in those areas. Overall, our framework indicates a baseflow response time for a precipitation of approximately two years for the smaller basins and three years for the biggest one. Such results can support the water allocation in conjunctive water management, by providing estimates of future surface water availability.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":133743643,"openaccessinfo":{"externalids":{"MAG":"2899672957","ACL":null,"DOI":"10.1111\/1752-1688.12696","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Integrity constraints are an important means to discover and specify application requirements. Although they are explicitly available and discussed during the system analysis and design phases, the constraint validation functionality is generally still tangled with other implementation code, e.g., the business logic, in today's systems. We contribute with an approach to decouple the integrity constraints from the business logic as well as the setpoints of constraint validation from the business activities. This allows us to balance dependability with respect to node and link failures by temporarily relaxing constraint consistency. Our prototype implementation indicates that this approach is typically worth its effort in systems where availability is of higher priority than strict consistency and a roll-forward approach to system repair, e.g., through compensating actions, is preferred over generic rollback-based solutions","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":15040819,"openaccessinfo":{"externalids":{"MAG":"2169505317","ACL":null,"DOI":"10.1109\/ARES.2007.64","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Permanent Magnet Synchronous Motors (PMSM) are widely used in low and mid power applications such as computer peripheral equipment, robotics, adjustable speed drives and electric vehicles. The growth in the market of permanent magnet motor drives has demanded the need of simulation tools capable of handling motor drive simulations. Simulations have helped the process of developing new systems including motor drives, by reducing cost and time. In a closed loop system, the speed of a permanent magnet synchronous motor can be controlled by measuring the actual speed of the motor. PI (Proportional Integral), PID (Proportional Integral Derivative) and fuzzy controllers are commonly used for the speed control. In this study, the speed responses of a PMSM are obtained using adaptive fuzzy PID controller. A parallel combination of two controllers, fuzzy PD controller and a fuzzy PI controller, forms the adaptive fuzzy PID controller. Switching action take place between the two controllers based on the error in the speed. MATLAB\/Simulink is used for the simulation. A comparison and analysis is made between PI controller and adaptive fuzzy logic controller. Keywords: Permanent Magnet Synchronous Motor (PMSM), PI controller, adaptive fuzzy, speed control Cite this Article Vishnu Mahesh J, Karthika S. Comparison of Speed Control of PMSM using Adaptive Fuzzy Logic Controller and PI Controller. Journal of Power Electronics & Power Systems. 2018; 8(3): 24\u201330p.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":196172755,"openaccessinfo":{"externalids":{"MAG":"2950912699","ACL":null,"DOI":"10.37591\/.V8I3.1324","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work addresses the joint analysis of multi-source and multi-resolution remote sensing data for the interpolation of high-resolution geophysical fields. As case-study application, we consider the interpolation of sea surface temperature fields. We propose a novel statistical model, which combines two key features: an exemplar-based prior and second-order statistical priors. The exemplar-based prior, referred to as a non-local prior, exploits similarities between local patches (small field regions) to interpolate missing data areas from previously observed exemplars. This non-local prior also sets an explicit conditioning between the multi-sensor data. Two complementary statistical priors, namely a prior on the spatial covariance and a prior on the marginal distribution of the high-resolution details, are considered as sea surface geophysical fields are expected to depict specific spectral and marginal features in relation to the underlying turbulent ocean dynamics. We report experiments on both synthetic data and real SST data. These experiments demonstrate the contributions of the proposed combination of non-local and statistical priors to interpolate visually-consistent and geophysically-sound SST fields from multi-source satellite data. We further discuss the key features and parameterizations of this model as well as its relevance with respect to classical interpolation techniques.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":133681804,"openaccessinfo":{"externalids":{"MAG":"2626683671","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"DEFECTIVE abduction is the result of various conditions having little in common other than a limitation in abduction. For this reason, it is evident that these various conditions are nonconcomitant. They have therefore few, if any, of the various causes of concomitant strabismus. In all cases the defective abduction is the result of a peripheral orbital defect, i. e., neuromuscular, of the muscle alone, or of the muscle and the fascia, or is due to a pathological condition of the central nervous system, i. e., congenital (perhaps developmental), disease of the central nervous system, trauma, or neoplasm. Three of the defects to be considered are usually spoken of as congenital. These are the Duane retraction syndrome, strabismus fixus, and so-called congenital sixth nerve paralysis. A fourth, to be discussed, is an acquired, or permanent, form of sixth nerve paralysis. THE RETRACTION SYNDROME The retraction syndrome is an interesting syndrome, or","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":29276519,"openaccessinfo":{"externalids":{"MAG":"2044273434","ACL":null,"DOI":"10.1001\/ARCHOPHT.1953.00920020052008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We use images of high spatial, spectral, and temporal resolution, obtained using both ground- and space-based instrumentation, to investigate the coupling between wave phenomena observed at numerous heights in the solar atmosphere. Analysis of 4170 \u00c5 continuum images reveals small-scale umbral intensity enhancements, with diameters \u223c0.\u20336, lasting in excess of 30 minutes. Intensity oscillations of \u22483 minutes are observed to encompass these photospheric structures, with power at least three orders of magnitude higher than the surrounding umbra. Simultaneous chromospheric velocity and intensity time series reveal an 87\u00b0 \u00b1 8\u00b0 out-of-phase behavior, implying the presence of standing modes created as a result of partial wave reflection at the transition region boundary. We find a maximum waveguide inclination angle of \u224840\u00b0 between photospheric and chromospheric heights, combined with a radial expansion factor of <76%. An average blueshifted Doppler velocity of \u22481.5 km s\u22121, in addition to a time lag between photospheric and chromospheric oscillatory phenomena, confirms the presence of upwardly propagating slow-mode waves in the lower solar atmosphere. Propagating oscillations in EUV intensity are detected in simultaneous coronal fan structures, with a periodicity of 172 \u00b1 17 s and a propagation velocity of 45 \u00b1 7 km s\u22121. Numerical simulations reveal that the damping of the magnetoacoustic wave trains is dominated by thermal conduction. The coronal fans are seen to anchor into the photosphere in locations where large-amplitude umbral dot (UD) oscillations manifest. Derived kinetic temperature and emission measure time series display prominent out-of-phase characteristics, and when combined with the previously established sub-sonic wave speeds, we conclude that the observed EUV waves are the coronal counterparts of the upwardly propagating magnetoacoustic slow modes detected in the lower solar atmosphere. Thus, for the first time, we reveal how the propagation of 3 minute magnetoacoustic waves in solar coronal structures is a direct result of amplitude enhancements occurring in photospheric UDs.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":53461945,"openaccessinfo":{"externalids":{"MAG":"2128905084","ACL":null,"DOI":"10.1088\/0004-637X\/757\/2\/160","PubMedCentral":null,"ArXiv":"1208.3194"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"After curative surgery for rectal or sigmoid cancer, loco-regional recurrence occurs in about 30% of the patients. Among them, one third presents no other tumor localization and a new curative surgical excision may, therefore be considered. A review of the literature shows that in these repeated procedures, the only good results, carcinologically, are observed when the original procedure consisted in a recto-colic anastomosis. Re-operations after abdomino-perineal resections have, until now, resulted in carcinologic failures. The location of the pelvic recurrence, after procedures which preserve the anal sphincter function, may be at the level of the anastomosis or most of the time around the anastomosis. If endoscopy is an easy mean of surveillance of the anastomosis, the screening of peri-anastomotic recurrences presents more of a problem. It seems necessary to use, in addition to rectal examination, other techniques which are more easily reproduced and compared with each other in the long run. This could be the case for endo-rectal sonography and pelvic tomodensitometry. As for re-operation itself, it consists essentially in an abdomino-perineal resection possibly associated with radiotherapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6963037,"openaccessinfo":{"externalids":{"MAG":"2411597160","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ModSecurity Handbook is the definitive guide to ModSecurity, a popular open source web application firewall. Written by Ivan Ristic, who designed and wrote much of ModSecurity, this book will teach you everything you need to know to monitor the activity on your web sites and protect them from attack. Situated between your web sites and the world, web application firewalls provide an additional security layer, monitoring everything that comes in and everything that goes out. They enable you to perform many advanced activities, such as real-time application security monitoring, access control, virtual patching, HTTP traffic logging, continuous passive security assessment, and web application hardening. They can be very effective in preventing application security attacks, such as cross-site scripting, SQL injection, remote file inclusion, and others. Considering that most web sites today suffer from one problem or another, ModSecurity Handbook will help anyone who has a web site to run. The topics covered include: - Installation and configuration of ModSecurity - Logging of complete HTTP traffic - Rule writing, in detail - IP address, session, and user tracking - Session management hardening - Whitelisting, blacklisting, and IP reputation management - Advanced blocking strategies - Integration with other Apache modules - Working with rule sets - Virtual patching - Performance considerations - Content injection - XML inspection - Writing rules in Lua - Extending ModSecurity in C The book is suitable for all reader levels: it contains step-by-step installation and configuration instructions for those just starting out, as well as detailed explanations of the internals and discussion of advanced techniques for seasoned users. The official ModSecurity Reference Manual is included in the second part of the book. Digital version available. For more information and to access the online companion, go to www.modsecurityhandbook.com","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":61203426,"openaccessinfo":{"externalids":{"MAG":"2338798019","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1a, 25-Dihydroxyvitamin D3 [1,25(OH)2D3] is a potential therapeutic agent for treatment of many clinical disorders, but its tendency to produce hypercalcemia at therapeutic dosages is a barrier to its usefulness. Derivatives of 1,25(OH)2D3 have been synthesized that possess the beneficial genomic activities of 1,25(OH)2D3 but have reduced nongenomic effects, which may be correlated with a tendency to produce hypercalcemia.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":85951017,"openaccessinfo":{"externalids":{"MAG":"2188512982","ACL":null,"DOI":"10.1152\/PHYSIOLOGYONLINE.1995.10.5.198","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Today there is no verified methodology to calculate oil reserves in the Bazhenov Formation, which makes it impossible to identify any references for the initial oil reserves. Therefore, the analog approach that is usually applied for quantitative assessment of petroleum potential becomes inapplicable.\n The paper considers different approaches to assessment of the petroleum potential of the Bazhenov Formation in West Siberia. Since oil distribution in the formation is determined by the initial content and catagenetic maturity of organic matter in the rock and controls the formation of an effective reservoir, it becomes apparent that estimating the oil resources and reserves requires geochemical studies.\n The proposed methodological approaches consider separation of net oil pays using the Rock-Eval data, well log data, and results of oil-promising objects survey and the principles of differentiated assessment of oil resources and territory ranking by the compositions of saturating hydrocarbons.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":242110032,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15372\/rgg2019014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate errors in syntax annotation with the Turku Dependency Treebank, a recently published treebank of Finnish, as study material. This treebank uses the Stanford Dependency scheme as its syntax representation, and its published data contains all data created in the full double annotation as well as timing information, both of which are necessary for this study. First, we examine which syntactic structures are the most error-prone for human annotators, and compare these results to those of a baseline automatic parser. We find that annotation decisions involving highly semantic distinctions, as well as certain morphological ambiguities, are especially difficult for both human annotators and the parser. Second, we train an automatic system that offers for inspection sentences ordered by their likelihood of containing errors. We find that the system achieves a performance that is clearly superior to the random baseline: for instance, by inspecting 10% of all sentences ordered by our system, it is possible to weed out 25% of errors.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":12958979,"openaccessinfo":{"externalids":{"MAG":"2604204702","ACL":null,"DOI":"10.3233\/978-1-61499-352-0-47","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Speech intelligibility is known to be affected by the relative spatial position between target and interferers. The benefit of a spatial separation is, along with other factors, related to the head-related transfer function (HRTF). The HRTF is individually different and thus, the cues that improve speech intelligibility might also be different. In the current study an auditory model was employed to predict speech intelligibility with a variety of HRTFs. The predicted speech intelligibility was found to vary across HRTFs. Thus, individual listeners might have different access to cues that are important for speech intelligibility.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":219689358,"openaccessinfo":{"externalids":{"MAG":"3035614368","ACL":null,"DOI":"10.1101\/2020.06.10.143792","PubMedCentral":null,"ArXiv":null},"license":"CCBYND","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2020\/06\/12\/2020.06.10.143792.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Objective: Genetic burden, fetal malformations, and fetal outcomes of 93 fetuses with cystic hygroma (CH) are reported from a single center in Turkey. Patients and Methods: Pregnancies, having a diagnosis of fetal CH, detected between January 2010 and October 2016, were included in the study except fetuses having increased nuchal translucency. Fetal age\/gender, maternal age, the age of pregnancy, types of fetal malformations, karyotype, and outcomes were evaluated. Results: The average gestational age was 16.2 weeks. Nearly 47% of the pregnancies had multiple congenital anomalies, of which 58% had a chromosomal anomaly. Chromosomal anomaly rate was 68.2% in patients with hydrops fetalis. Aneuploidies were major chromosomal defects. All trisomies were of regular type except one with Robertsonian translocation (46, XY, +13, rob[13;14][q10;q10]). Seventy-four percentage pregnancies were terminated due to either fetal\/karyotype anomaly. Conclusion: Characteristics of fetal CH were similar in different ethnical backgrounds. Aneuploidy is the dominant chromosomal constitution of fetal CH. Little information was known about the genes involved. Gene dosage effect implies that fetal CH is a complex genetic situation involving multiple genes interactions. For proper genetic counseling, each fetus with CH should be karyotyped, and fetal ultrasound examination should be performed. In the case of normal chromosome set, application of aCGH should be considered.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":145840071,"openaccessinfo":{"externalids":{"MAG":"2935924587","ACL":null,"DOI":"10.4103\/JMU.JMU_114_18","PubMedCentral":"6905260","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Diagnosis, to some, means the categorization or naming of a particular disease state. Others take a more extended view, holding that diagnosis must include delineation of the nature and origins of the disease state at hand with particular effort toward those areas in which a potential solution is available. This has been called epidemiologic diagnosis. In most instances of neonatal dairy calf diarrhea, agentidentification is not diagnostic from an epidemiologic (solution-oriented) standpoint. The underlying causes may be identified only by a meticulous examination of management practices.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":257301852,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21423\/aabppro19827433","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/bovine-ojs-tamu.tdl.org\/AABP\/article\/download\/7433\/7280","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION: Posterior lumbar interbody fusion (PLIF) is an established technique that allows circumferential fusion of lumbar spine through a single incision. A variation of PLIF called transforaminal lumbar interbody fusion (TLIF) uses a posterior approach to the spine but accesses the disc space via a path that runs through the far lateral portion of the vertebral foramen. TLIF provides the surgeon with a fusion procedure that reduces many of the risks and limitations associated with PLIF. Like PLIF, TLIF is easily enhanced when combined with posterolateral fusion (PLF) and instrumentation. TLIF offers an advantage in that it is usually done via a unilateral approach preserving the facet joint and the interlaminar surface on the contralateral side (1). It minimizes soft tissue stripping and neural element retraction compared to PLIF, while providing a single-stage circumferential fusion. This study compared the biomechanical performance of these two constructs in flexion, extension, and lateral bending under physiologic compressive preloads.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37647773,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This commentary on the articles collected in this issue confirms that they illustrate effectively the main approaches to historical comparison for Africa in recent centuries. The essay reaffirms A.I. Asiwaju's introductory statement of the crucial importance of comparative work in advancing studies of African history, and amplifies this argument by asserting that comparative and global frameworks each have their place, and that each can be employed as a tactic or strategy in historical analysis. The discussion continues with exploration of three articles that explore the rules for and results of historical comparison; three articles comparing cases that overlap and interact with each other; and three articles comparing discrete cases. The essay concludes by summarizing the ways that the comparisons, in the various studies, have clarified narratives and have documented historical processes. Overall, it appears, the articles are effective in showing how comparisons can advance understanding of what Professor Asiwaju has called 'the history of man in Africa'.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260151477,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.57054\/az.vi11-12.1871","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.codesria.org\/index.php\/az\/article\/download\/1871\/1930","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Successful navigation requires the ability to compute one's location and heading from incoming multisensory information. Previous work has shown that this multisensory input comes in two forms: body-based idiothetic cues, from one's own rotations and translations, and visual allothetic cues, from the environment (usually visual landmarks). However, exactly how these two streams of information are integrated is unclear, with some models suggesting the body-based idiothetic and visual allothetic cues are combined, while others suggest they compete. In this paper we investigated the integration of body-based idiothetic and visual allothetic cues in the computation of heading using virtual reality. In our experiment, participants performed a series of body turns of up to 360 degrees in the dark with only a brief flash (300ms) of visual feedback en route. Because the environment was virtual, we had full control over the visual feedback and were able to vary the offset between this feedback and the true heading angle. By measuring the effect of the feedback offset on the angle participants turned, we were able to determine the extent to which they incorporated visual feedback as a function of the offset error. By further modeling this behavior we were able to quantify the computations people used. While there were considerable individual differences in performance on our task, with some participants mostly ignoring the visual feedback and others relying on it almost entirely, our modeling results suggest that almost all participants used the same strategy in which idiothetic and allothetic cues are combined when the mismatch between them is small, but compete when the mismatch is large. These findings suggest that participants update their estimate of heading using a hybrid strategy that mixes the combination and competition of cues. Author summary Successful navigation requires us to combine visual information about our environment with body-based cues about our own rotations and translations. In this work we investigated how these disparate sources of information work together to compute an estimate of heading. Using a novel virtual reality task we measured how humans integrate visual and body-based cues when there is mismatch between them \u2014 that is, when the estimate of heading from visual information is different from body-based cues. By building computational models of different strategies, we reveal that humans use a hybrid strategy for integrating visual and body-based cues \u2014 combining them when the mismatch between them is small and picking one or the other when the mismatch is large.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":235718071,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pcbi.1009222","PubMedCentral":"8865642","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/ploscompbiol\/article\/file?id=10.1371\/journal.pcbi.1009222&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aim : To examine the relationship between chronic bronchitis and chronic obstructive pulmonary disease (COPD), and type 2 diabetes in adult twins. Methods : Questionnaire data on chronic bronchitis and hospital data on diagnosed COPD on 13,649 twins, 50-71 years of age, from the Danish Twin Registry, were cross-linked with hospital discharge diagnosis data on type 2 diabetes from the Danish National Patient Registry. Results : The risk of type 2 diabetes was higher in subjects with symptoms of chronic bronchitis compared with subjects without symptoms of chronic bronchitis (3.5 vs. 2.3%), OR=1.53 (1.09 - 2.15), p=0.013; and in subjects with diagnosed COPD compared with subjects without diagnosed COPD (6.6 vs. 2.3%), OR=2.97 (1.95-4.53), p=0.000. The results were significant after adjusting for age, sex, and smoking. Correlations between genetic effects on chronic bronchitis and type 2 diabetes; and between genetic effects on diagnosed COPD and type 2 diabetes, respectively, were 0.25 (0.00-0.59), p=0.130 and 0.35 (0.00-0.72), p=0.134. Conclusions : Patients with chronic bronchitis and COPD have an increased risk of type 2 diabetes independently of sex, age, and smoking. Furthermore, comorbidity between these diseases seemed not to be explained by shared genetic factors. The increased risk of type 2 diabetes must be accommodated in the management of patients with chronic bronchitis and COPD.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":58448483,"openaccessinfo":{"externalids":{"MAG":"1949192239","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An approximate answer to the right problem is worth a good deal more than an exact answer to an approximate problem. (Tukey 1962) Introduction Chapters 3 and 4 introduced a number of new concepts and models to the reader, including the probit and logit models. As seen in Chapter 4, probit and logit models are derived under different assumptions about the error term. For probit models, the error terms are assumed to be multivariate Normally distributed, while logit models assume a multivariate extreme value Type 1 distribution, or some restriction thereof. In Chapter 4, we briefly discussed the fact that discrete choice models are estimated using a method known as maximum likelihood estimation. The current chapter seeks to explain maximum likelihood estimation in the context of discrete choice models. In doing so, we also briefly discuss several of the more common algorithms used in estimating discrete choice models. In addition to discussing maximum likelihood estimation, we also introduce the related concept of simulated maximum likelihood. A number of the models introduced in Chapter 4 do not have analytically tractable solutions when one attempts to compute their choice probabilities. Such models are said to be of open form, requiring simulation of the choice probabilities. We therefore discuss the several common simulation approaches used in estimating discrete choice models.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":156202581,"openaccessinfo":{"externalids":{"MAG":"2494730475","ACL":null,"DOI":"10.1017\/CBO9781316136232.007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ability to obtain dynamic control over an antenna radiation pattern is one of the main functions, desired in a vast range of applications, including wireless communications, radars, and many others. Widely used approaches include mechanical scanning with antenna apertures and phase switching in arrays. Both of those realizations have severe limitations, related to scanning speeds and implementation costs. Here we demonstrate a solution, where the antenna pattern is switched with optical signals. The system encompasses an active element, surrounded by a set of cylindrically arranged passive dipolar directors, functionalized with tunable impedances. The control circuit is realized as a bipolar transistor, driven by a photodiode. Light illumination in this case serves as a trigger, capable of either closing or opening the transistor, switching the impedance between two values. Following this approach, a compact half-a-wavelength footprint antenna, capable of switching between 6 dBi directional patterns within a few milliseconds' latency was demonstrated. The developed light activation approach allows constructing devices with multiple almost non-interacting degrees of freedom, as a branched feeding network is not required. The capability of flexible switching between multiple electromagnetic degrees of freedom opens pathways to new wireless applications, where fast beam steering and beamforming performances are required.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":255372442,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/2040-8986\/acf1ae","PubMedCentral":null,"ArXiv":"2301.00770"},"license":"CCBY","url":"https:\/\/iopscience.iop.org\/article\/10.1088\/2040-8986\/acf1ae\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The cross section of ee \u2192 bb\u0304ud\u0304\u03bc\u2212\u03bd\u0304\u03bc process with a complete set of tree diagrams, 232 diagrams in the unitary gauge, was calculated at the energy range of \u221a s = 340 500 GeV by using GRACE system. A main contribution to the cross section comes from tt\u0304 production, where t and t\u0304 decay into bud\u0304 and b\u0304\u03bc\u2212\u03bd\u0304\u03bc, respectively. It was found that the interference between the diagrams with tt\u0304 production and those with single-t through WW pair production amounts to 10% at the tt\u0304 threshold energy region. In the energy region above twice of the top quark mass, more than 95% of the cross section comes from the tt\u0304 diagrams. email@example.com firstname.lastname@example.com firstname.lastname@example.com","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15409291,"openaccessinfo":{"externalids":{"MAG":"58286142","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We simultaneously extend the models developed by Stewart, Paroush & Wolf, and Viaene & Zilcha. That is, allowing output to adjust and using a general utility, general distributions and a two-variable-input production function, we show the impact of the cost risk and increasing risk aversion on each input demand, output, input productivity (marginal and average), and the inputs ratio.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":154101382,"openaccessinfo":{"externalids":{"MAG":"2015137822","ACL":null,"DOI":"10.1080\/1351161042000320425","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: To examine whether transcatheter closure of secundum atrial septal defect (ASD) with the Amplatzer septal occluder leads to more myocardial injury in children than in adults. Design: In a prospective study with children and adults cardiac troponin I (cTnI) serum concentrations were determined by immunoassay (AxSYM, Abbott Laboratories) before, during, and up to 20 months after surgical or transcatheter ASD closure. Patients: Four groups of patients were studied: transcatheter ASD closure (group 1: 22 children, age range 3.26\u201314.7 years; group 2: 22 adults, 18.0\u201367.3 years), surgical ASD closure (group 3: 18 children, 3.12\u201313.5 years), and diagnostic catheterisation (group 4: 12 children, 2.68\u201315.0 years). Results: cTnI concentrations were significantly increased after occluder implantation with higher serum concentrations in children than in adults (immediately after implantation: group 1, 3.2 (4.4) \u03bcg\/l; group 2, 1.1 (4.2) \u03bcg\/l; four hours after implantation: group 1, 4.8 (5.0) \u03bcg\/l; group 2, 1.7 (2.3) \u03bcg\/l; both p < 0.01, group 1 v group 2; one day after implantation: group 1, 3.0 (5.7) \u03bcg\/l; group 2, 2.2 (5.2) \u03bcg\/l) but were less than 20% of those after surgical ASD closure (group 3; p < 0.001) where the highest cTnI concentration was found (37.1 (26.3) \u03bcg\/l). Diagnostic catheterisation (group 4) was not associated with detectable cTnI increase. From the cTnI concentrations the total amount of cTnI released after ASD closure was estimated for each patient. This was dependent on the size of the occluder (p < 0.05) but not on the patient's age or procedural duration. Conclusion: In regard to interventional ASD closure our data do not provide evidence that the child's myocardium is more vulnerable. Transcatheter ASD closure induces minor myocardial lesion, the extent of which depends on the size of the Amplatzer septal occluder but is irrespective of the patient's age.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11143336,"openaccessinfo":{"externalids":{"MAG":"2159138591","ACL":null,"DOI":"10.1136\/hrt.2003.029884","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/heart.bmj.com\/content\/heartjnl\/91\/2\/219.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The aim of this research is to explain and describe the da'wah of mualamah in Islam. The research was conducted qualitatively through library research. Data collection was carried out by means of a documentation study using books, books, the internet, and so on. Data processing with reduction, presentation, and conclusion. The results of the study showed: (1) aspects of da'wah: mad'u abilities, geographic location, materials, and tools of da'wah. (2) muamalah aspects: contracts, liking each other, and goods sold are beneficial. (3) Da'wah mulamalah about: capital, honesty, punctuality, hard work, hard work, and motivating the closest people.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":259798325,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.54150\/syiar.v3i1.207","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/jurnal.staithawalib.ac.id\/index.php\/syiar\/article\/download\/207\/135","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"In this paper, a method of decision tree-based computation of security regions and boundaries for power systems is proposed. These computations are used in dynamic security enhancement via generation rescheduling against transient instabilities. This work also involves an iterative method of generation rescheduling using the security regions calculated by decision trees. The proposed methods are implemented and their performances are assessed on the Iowa power system model.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":9288442,"openaccessinfo":{"externalids":{"MAG":"2040249495","ACL":null,"DOI":"10.1109\/PES.2010.5589364","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we introduce a framework for probabilistic logic-based argumentation inspired on the DeLP formalism and an extensive use of conditional probability. We define probabilistic arguments built from possibly inconsistent probabilistic knowledge bases and study the notions of attack, defeat and preference between these arguments. Finally, we discuss consistency properties of admissible extensions of the Dung's abstract argumentation graphs obtained from sets of probabilistic arguments and the attack relations between them.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":243865627,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3233\/faia210111","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.3233\/faia210111","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Background: Pelvic organ prolapse in elder women causes sufficient morbidity and decreased quality of life. Despite age related comorbidities and decreased physiological capabilities, elder women with pelvic organ prolapse may be benefitted by surgical repair via vaginal route.The purpose of this study is to evaluate the safety of vaginal repair of pelvic organ prolapse in women of age 60 years or older. \nMaterials and Methods: This hospital based analytical study was carried out in Birat Medical College Teaching Hospital from September 2020 to September 2021. Fifty-four patients aged 60 years or older with third and fourth degree pelvic organ prolapse were recruited for the study. Necessary information was obtained by self-structured questionnaire and entered into Microsoft Excel. Data was analyzed by SPSS version 22. \nResults: Fifty-four women with third or fourth degree prolapse with cystocele and rectocele underwent vaginal hysterectomy with anterior colporrhaphy with posterior colpoperineorrhaphy. No organ injury occurred during operation. There was no mortality or severe intraoperative or postoperative complications. \nConclusion: Vaginal hysterectomy with pelvic floor repair for pelvic organ prolapse in women of 60 years or older is safe.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":245664668,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3126\/jonmc.v10i2.41580","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3126\/jonmc.v10i2.41580","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Although discrete event simulation has made significant progress in the health care field, it has been tested primarily in hospitals and specialty clinics. Our mission was to assess the effectiveness and economics of simulation in fiee standing ambulatory health care settings. Our fmdings to date indicate a good fit of simulation tools for the objective of total business process improvement. In addition to the simulation tools, we used other hardware and software solutions to meet the special needs of small businesses such as small health care providers. Critical success factors for the project were visual mapping and simulation tools, extensive energy and time in process and resource mapping, data collection methods, technologies that minimize on-site time for client and consultant, and the importance of having a clinical healthcare professional on the consultant team. The techniques detailed in this paper can be applied to diverse simulation projects for effective results.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263879737,"openaccessinfo":{"externalids":{"MAG":"2186643866","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is well-known that the set $\\mathbf I_n$ of involutions of the symmetric\ngroup $\\mathbf S_n$ corresponds bijectively - by the Foata map $F$ - to the set\nof $n$-permutations that avoid the two vincular patterns $\\underline{123},$\n$\\underline{132}.$ We consider a bijection $\\Gamma$ from the set $\\mathbf S_n$\nto the set of histoires de Laguerre, namely, bicolored Motzkin paths with\nlabelled steps, and study its properties when restricted to $\\mathbf\nS_n(1\\underline{23},1\\underline{32}).$ In particular, we show that the set\n$\\mathbf S_n(\\underline{123},{132})$ of permutations that avoids the\nconsecutive pattern $\\underline{123}$ and the classical pattern $132$\ncorresponds via $\\Gamma$ to the set of Motzkin paths, while its image under $F$\nis the set of restricted involutions $\\mathbf I_n(3412).$ We exploit these\nresults to determine the joint distribution of the statistics des and inv over\n $\\mathbf S_n(\\underline{123},{132})$ and over $\\mathbf I_n(3412).$\n Moreover, we determine the distribution in these two sets of every\nconsecutive pattern of length three. To this aim, we use a modified version of\nthe well-known Goulden-Jacson cluster method.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119130660,"openaccessinfo":{"externalids":{"MAG":"2950317367","ACL":null,"DOI":"10.23638\/DMTCS-21-3-21","PubMedCentral":null,"ArXiv":"1902.02213"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many mammals in Australia's tropical north are in severe decline, yet understanding of the drivers of this decline is remarkably limited. Recently, Fisher et\u2009al. (Global Ecology and Biogeography, 2014, 23, 181\u2212190) examined the traits that are associated with declining marsupial species in northern Australia. They concluded that, in this region, declines are most pronounced in the smallest species (those with the lowest body mass). This is in strong contrast to the significant declines that occurred earlier in central and southern Australia before the mid 20th century, which were most pronounced in medium-sized species, the so-called 'critical weight range' (35\u22125500\u2009g). Here we show that Fisher et\u2009al. have misinterpreted their dataset; in northern Australia, the pattern of mammal decline in relation to body mass is remarkably similar to that in central and southern Australia, with mammal decline strongly concentrated in the critical weight range, suggesting fundamentally similar drivers between north and south.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":82033590,"openaccessinfo":{"externalids":{"MAG":"1544241587","ACL":null,"DOI":"10.1111\/GEB.12173","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lipid peroxidation (LPO) activity has been analyzed in homogenates and microsomes of cortical samples obtained intraoperatively from the kidneys of 33 patients. Of them, 21 patients had mild, moderate or severe pyelonephritis or nephrolithiasis. Unaffected cortical tissue from renal carcinoma patients was used as control. LPO activity was judged by basal level of malonic dialdehyde (MDA) and MDA growth in the homogenate and microsomes following initiation of ascorbate-dependent LPO. Activation of LPO was registered in patients with moderate disease with active inflammation. They also exhibited greater MDA basal levels and rapid MDA increase in response to in vitro initiation of ascorbate-dependent LPO simultaneously with attenuation of endogenous antioxidant defense. In severe pyelonephritis and nephrolithiasis with drastic deficiency of renal function LPO activity was low and nonresponsive to stimulation either by ascorbate or Fe+2. This is probably due to lack of the substrate after massive death of renal cells. Enhancement of LPO activity in patients with pyelonephritis or nephrolithiasis against functioning kidneys may appear responsible for destruction of renal tissue.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29040023,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper devotes to the design and implementation of a hybrid artificial intelligent control scheme for a car-like vehicle through the performance optimization of the task of car parking. The genetic algorithm is used to determine the feasible parking locations. The Petri-net is used to replace the traditional system flow chart and most importantly, to plan alternative parking routes especially in a global space. A fuzzy controller is utilized to drive the car along the optimal parking route.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":13544668,"openaccessinfo":{"externalids":{"MAG":"2109199347","ACL":null,"DOI":"10.1109\/ICARA.2000.4803930","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. Robust optical phase modulation (PM) schemes have been widely employed in the development of radio-over-fiber (RoF) transport systems. However, the signals produced by these PM schemes require a delay line interferometer (DI), a fiber Bragg grating (FBG), an optical band-pass filter (OBPF), or dedicated dispersive devices to convert them back into the intensity modulation (IM) signal format prior to detection by a photodetector (PD). Inserting a costly DI into a transport link can significantly increase overall cost, and the use of a fixed working window OBPF, FBG, or dedicated dispersive devices to achieve the conversion is inflexible. To overcome these problems in PM-based RoF transport systems, a long-reach RoF link with an innovative PM-to-IM converter is proposed and experimentally demonstrated. Compared with the published PM schemes, the proposed architecture can utilize a vertical-cavity surface-emitting laser (VCSEL) to achieve the same performance of the published PM-to-IM converter at a lower cost. In addition, by adjusting the VCSEL driving current, a tunable range exceeding 350 GHz is experimentally obtained for the converter working window. The proposed long-reach RoF transport system is the first to achieve such PM-to-IM conversion by using a VCSEL and can contribute to the development of RoF transport systems.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":121163236,"openaccessinfo":{"externalids":{"MAG":"2023819640","ACL":null,"DOI":"10.1117\/1.OE.52.11.116107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This critique of Mahler's derivation of a developmental stage of normal symbiosis from her work with psychotic children reveals some clear parallels with Klein's description of the paranoid-schizoid position. The defence mechanisms of splitting, and of projective and introjective identification are already operative in the symbiotic stage and imply some distinction between self and other in the unconscious. Both theorists described the same confusion between self and other, but they attributed different explanations to the phenomenon. Whereas Mahler described the experience of feeling at one with the other, Klein elucidated the unconscious psychic mechanisms which operate to create this experience. The separation-individuation process has been redefined as the developing awareness of a sense of self, as distinct from earlier unconscious processes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41422736,"openaccessinfo":{"externalids":{"MAG":"1630345218","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Combining diverse sampling techniques via multiple importance sampling (MIS) is key to achieving robustness in modern Monte Carlo light transport simulation. Many such methods additionally employ correlated path sampling to boost efficiency. Photon mapping, bidirectional path tracing, and path\u2010reuse algorithms construct sets of paths that share a common prefix. This correlation is ignored by classical MIS heuristics, which can result in poor technique combination and noisy images. We propose a practical and robust solution to that problem. Our idea is to incorporate correlation knowledge into the balance heuristic, based on known path densities that are already required for MIS. This correlation\u2010aware heuristic can achieve considerably lower error than the balance heuristic, while avoiding computational and memory overhead.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235337883,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/cgf.142628","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/cgf.142628","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Connections have been observed between police involvement in school discipline and the utilization of suspensions as punishment. While proponents of school surveillance believe that police are necessary\u00a0to provide safety in schools, education advocates question students' perception of safety and its effects on educational outcomes. This article examines the relationship between police officer presence and certain educational outcomes, including student attendance, access to higher education, standardized test scores, and suspension rates. Also included in this analysis is an exploration of the relationships between these variables and classroom restorative circles used to manage conflict and find alternative solutions to safety. Does police presence have a significant impact upon attendance, access to higher education, standardized test scores, and suspension rates for students? Does the use of restorative circles at school, an alternative to traditional student discipline, have a significant impact upon attendance, access to higher education, standardized test scores, and suspension rates for students? To address these inquiries, an Ordinary Least Squares (OLS) regression analysis is used on both predictors with the School Survey on Crime and Safety collected by the U.S. Department of Education (DOE). Results demonstrate a statistically significant relationship between police officer presence and suspensions. Restorative circle use in schools has a significant impact upon decreased school suspensions and increased standardized test scores. To conclude the paper, real-world implications on school policy development are discussed.\nKeywords: police in schools, suspension rates, educational outcomes, restorative justice circles, standardized test scores","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":248910864,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.52214\/cswr.v20i1.9640","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/journals.library.columbia.edu\/index.php\/cswr\/article\/download\/9640\/4883","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Members of the fungal genus Fusarium can produce numerous secondary metabolites, including the nonribosomal mycotoxins beauvericin (BEA) and enniatins (ENNs). Both mycotoxins are synthesized by the multifunctional enzyme enniatin synthetase (ESYN1) that contains both peptide synthetase and S-adenosyl-l-methionine-dependent N-methyltransferase activities. Several Fusarium species can produce ENNs, BEA or both, but the mechanism(s) enabling these differential metabolic profiles is unknown. In this study, we analyzed the primary structure of ESYN1 by sequencing esyn1 transcripts from different Fusarium species. We measured ENNs and BEA production by ultra-performance liquid chromatography coupled with photodiode array and Acquity QDa mass detector (UPLC-PDA-QDa) analyses. We predicted protein structures, compared the predictions by multivariate analysis methods and found a striking correlation between BEA\/ENN-producing profiles and ESYN1 three-dimensional structures. Structural differences in the \u03b2 strand's Asn789-Ala793 and His797-Asp802 portions of the amino acid adenylation domain can be used to distinguish BEA\/ENN-producing Fusarium isolates from those that produce only ENN.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":18936496,"openaccessinfo":{"externalids":{"MAG":"2581354198","ACL":null,"DOI":"10.3390\/toxins9020045","PubMedCentral":"5331425","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6651\/9\/2\/45\/pdf?version=1485338482","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose \n \n \n \n \nDespite multiple studies of customer delight in various service industries, limited research exists in the hedonically driven theme park context. The purpose of this paper is to explore the key drivers of customer delight and outrage in theme parks by analyzing TripAdvisor's comments from visitors to the top 20 North American theme parks. \n \n \n \n \nDesign\/methodology\/approach \n \n \n \n \nFollowing the analysis of thousands of extremely positive and negative comments using MAXQDA qualitative software, keywords drivers of delight and outrage were identified. The researchers applied both thematic and root cause in order to ascertain the sources leading to both positive and negative consumer feedback. \n \n \n \n \nFindings \n \n \n \n \nDelighted guests relayed various aspects of their experience including positive affect experience, positive value perceptions, and limited wait times. Root causes that influenced customer delight included: excellent core product, quality food and beverage, servicescape, pricing decisions, and low visitor demand or sensible admissions policies. Outraged guests described various aspects of their experiences such as negative perceptions of value, long waits, poor customer service, and negative emotions. Root causes for customer outrage included low quality or deficient core products, poor quality of food and beverage, poor facility maintenance, aggressive pricing decisions, poor staff selection, training, and working conditions, and high customer demand on any given date or aggressive admissions policies. \n \n \n \n \nOriginality\/value \n \n \n \n \nThe present research is unique in that it exposes the key themes of customer delight and outrage in the theme park setting, presents a conceptual model, and analyzes its root causes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":168848175,"openaccessinfo":{"externalids":{"MAG":"2773135974","ACL":null,"DOI":"10.1108\/JHTI-10-2017-0011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conservation of thermally sensitive species depends on monitoring organismal and population-level responses to environmental change in real time. Epigenetic processes are increasingly recognized as key integrators of environmental conditions into developmentally plastic responses, and attendant epigenomic datasets hold potential for revealing cryptic phenotypes relevant to conservation efforts. Here, we demonstrate the utility of genome-wide DNA methylation (DNAm) patterns in the face of climate change for a group of especially vulnerable species, those with temperature-dependent sex determination (TSD). Due to their reliance on thermal cues during development to determine sexual fate, contemporary shifts in temperature are predicted to skew offspring sex ratios and ultimately destabilize sensitive populations. Using reduced-representation bisulfite sequencing, we profiled the DNA methylome in blood cells of hatchling American alligator (Alligator mississippiensis), a TSD species lacking reliable markers of sexual dimorphism in early life-stages. We identified 120 sex-associated differentially methylated cytosines (DMCs; FDR < 0.1) in hatchlings incubated under a range of temperatures, as well as 707 unique temperature-associated DMCs. We further developed DNAm-based models capable of predicting hatchling sex with 100% accuracy and past incubation temperature with a mean absolute error of 1.2\u00b0C based on the methylation status of 20 and 24 loci, respectively. Though largely independent of epigenomic patterning occurring in the embryonic gonad during TSD, DNAm patterns in blood cells may serve as non-lethal markers of hatchling sex and past incubation conditions in conservation applications. These findings also raise intriguing questions regarding tissue-specific epigenomic patterning in the context of developmental plasticity.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-10":1,"unknown":2}},"corpusid":248546302,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/mec.16670","PubMedCentral":"9826120","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9826120","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background \nThe Royal Australian Chemical Institute (RACI) is the qualifying body in Australia for professional chemical scientists, and a learned society promoting the science and practice of chemistry. The RACI accredits Bachelor's level chemistry courses in Australia, which is designed to ensure that graduates of accredited courses have the skills and knowledge necessary to be a practicing chemist and member of the Institute. However, until very recently, the criteria for accreditation were input-driven and placed significant resource demands on curriculum. With the advent of the new Higher Education Standards Framework, and its outcomes and assessment focus,1 the RACI embarked on realigning its accreditation process to this framework. \n \nOutcomes \nThe skills and knowledge of a graduate of a bachelor degree majoring in chemistry are articulated in the Chemistry Academic Standards Statement,2 which is a derivative of the statement for science.3 This statement represents the current consensus view of the Australian chemical sciences community and defines the minimum Threshold Learning Outcomes (TLOs) of a pass bachelor's degree in chemistry. \n \nApproach \nTo evidence the attainment of the Chemistry TLOs the notion of curriculum described by Rosier and Keeves4 and extended by Treagust5 was adapted. The accreditation process has four stages of curriculum review: Intended: the Chemistry TLOs are the intended curriculum; Implemented: each institution interprets each of the TLOs, and reports their self-assessment of student attainment in a curriculum map; Perceived: an accreditation panel validates the alignment between the intended and implemented curriculum before recommending the award of accredited status for a given programme or programmes, and; Achieved: this accreditation panel summarises the student achievement through the lens of the Chemistry TLOs. \n \nQuestions \nSome questions have emerged during the implementation of the new RACI accreditation regime, which is of interest to anyone teaching undergraduate science and will be addressed through this presentation: \n\u2022 How do we assess for and assure outcomes at the program level? \n\u2022 What is the evidence to support students' achievement of outcomes? \n\u2022 Are graduates achieving the outcomes needed for employment? \n\u2022 What is the current state of play of chemistry courses around Australia? \n \nReferences \n(1) Higher Education Standards Framework (Threshold Standards) 2015, pt A, s 1.4. \n(2) Pyke, S. M.; OBrien, G.; Yates, B. J.; Buntine, M. A. Chemistry Academic Standards Statement; Office for Learning and Teaching and The Royal Australian Chemical Institute, 2014. \n(3) Yates, B. J.; Jones, S.; Kelder, J. Science Learning and Teaching Academic Standards Statement; Australian Learning and Teaching Council: Melbourne, 2011. \n(4) Rosier, M. J.; Keeves, J. P. The IEA study of science I: Science education and curricula in twenty-three countries; Pergamon Press, 1991. \n(5) Treagust, D. F. Exemplary Practice in High School Biology Classes. NARST Annual Meeting, San Francisco, 1986.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":91116771,"openaccessinfo":{"externalids":{"MAG":"2808540191","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The strength and elongation, the unevenness and the number of hairiness of the soybean protein fiber\/fine-polyester blended yarn are tested. By the analysis of these results, the optimum blended ratio of the blended yarn is determined.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137394022,"openaccessinfo":{"externalids":{"MAG":"2028100135","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMR.496.435","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim: Multivascular disease, indicating concurrent arteriosclerotic lesions in a number of different vascular beds, is an independent risk factor for recurrent ischemic events in the general population. However, the impact of multivascular disease on the risk of developing cardiovascular disease has not been fully evaluated in patients receiving hemodialysis. Methods: A total of 3,504 hemodialysis patients were prospectively followed for 10 years. In this study, multivascular disease was defined as the coexistence of coronary artery disease and stroke. We examined the relationship between multivascular disease and the occurrence of composite cardiovascular endpoint, consisting of cardiovascular death, nonfatal coronary artery disease, nonfatal stroke, and peripheral artery disease. Results: The proportion of participants with multivascular disease was 5.7% (n = 200) at baseline. During follow-up (median, 106.6 months; interquartile range, 50.1\u2013121.8 months), 1,311 patients experienced the composite endpoint, which was defined as at least one of the following: cardiovascular death (n = 620), nonfatal coronary artery disease (n = 318), nonfatal stroke (n = 340), and peripheral artery disease (n = 257). Compared with the group with no history of cardiovascular disease, the risk of experiencing the composite endpoint increased significantly with higher numbers of injured vascular beds in patients with single vascular disease (hazard ratio, 1.68; 95% confidence interval, 1.49\u20131.89) and in those with multivascular disease (hazard ratio, 2.11; 95% confidence interval, 1.71\u20132.60). In a multivariable analysis, multivascular disease was an independent predictor of cardiovascular events, in addition to diabetes, aging, and hypertension. Conclusions: This study clearly demonstrated that multivascular disease was a powerful predictor for cardiovascular mortality and morbidity in patients receiving hemodialysis.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":220653968,"openaccessinfo":{"externalids":{"MAG":"3042566371","ACL":null,"DOI":"10.5551\/jat.54098","PubMedCentral":"8147568","ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/28\/4\/28_54098\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Spyrou, A. 2018. Heparan Sulfate Proteoglycans in Brain Tumor Development. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1518. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0514-1. Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. The exceptionally invasive behavior of tumor cells, causing infiltrative disease, is among the reasons why these brain tumors often remain fatal. This thesis focuses on a group of molecules of the brain tumor microenvironment, heparan sulfate proteoglycans (HSPGs), and their roles in development of malignant brain tumors. The extracellular matrix in the brain has a unique composition with abundant HSPGs, and the hypothesis was, therefore, that heparan sulfate (HS)-degrading and HS-biosynthetic enzymes may have an important role in glioma and pediatric brain tumors. In our first study, we describe the role of the HS degrading enzyme, heparanase (HPSE), in glioblastoma (GBM) development, as well as its clinical relevance. A series of mechanistic studies revealed the effect of HPSE on signaling pathway activation and its protumorigenic activity in vitro and in vivo. Next, we expanded our work to encompass HPSE in pediatric brain tumors by presenting evidence of high HPSE expression in human tumors, and in cells derived from patients. We showed that tumor cell growth and invasion were increased by HPSE, an effect that could be inhibited by pharmacological treatment against the enzyme, suggesting that HPSE could be a targetable molecule in these tumors. We further explored the molecular mechanisms underlying the pro-tumorigenic properties of HPSE and in study III we describe a novel HPSE-CD24-L1CAM axis which was found to influence glioma tumorigenesis. Clinical data revealed a significantly shorter patient survival in HPSE-high\/CD24-high tumors compared to CD24-low tumors, and experiments in mice showed that anti-CD24 and anti-L1CAM treatment inhibited tumor growth. In the fourth study, we investigated the dysregulation of the HS biosynthetic machinery and focused on N-deacetylase\/N-sulfotransferase 1 (NDST1) in GBM development. We show overall low NDST1 expression levels across GBM patient samples, and patient-derived cell lines, and that low NDST1 levels correlate to poorer patient survival. Furthermore, altering the NDST1 expression had profound effects on GBM cell invasion, migration and stemness.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":202593674,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This report describes the technique of integrated myocardial management, which combines the advantages of various cardioprotective strategies to compensate for their individual shortcomings. This approach coordinates the myocardial protective techniques with the continuity of the operation so that the surgical procedure is never interrupted. This method (1) provides unimpaired vision, (2) avoids unnecessary ischemia and cardioplegic overdose, (3) allows aortic clamping as soon as cardiopulmonary bypass is started, (4) permits aortic un\u2010clamping and discontinuation of bypass shortly after the technical procedure is completed, (5) minimizes the duration of ischemia and cardiopulmonary bypass, and (6) maximizes the positive attributes of the strategies available currently. The background for this myocardial management method, which combines antegrade\/retrograde delivery, warm\/cold blood cardioplegia, intermittent\/continuous perfusion, blood\/blood cardioplegia, and avoidance of cardioplegic overdose, hemodilution, and tangential aortic clamping, is discussed. The preliminary results in 1474 patients from four centers where surgeons participated in the infrastructure of this method are presented. This has led to our adoption of this approach in all adult cardiac operations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9923802,"openaccessinfo":{"externalids":{"MAG":"2054093846","ACL":null,"DOI":"10.1111\/j.1540-8191.1995.tb00594.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1111\/j.1540-8191.1995.tb00594.x","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The internal reflux effect on dialysis through the retentate phase of a countercurrently cross-flow rectangular module is investigated. Theoretical analysis of mass transfer in cross-flow devices with or without recycling is analogous to heat transfer in cross-flow heat exchangers. In contrast to a device without reflux, considerable mass transfer is achievable if cross-flow dialyzers are operated with reflux, which provides an increase in fluid velocity, resulting in a reduction in mass-transfer resistance. It is concluded that reflux can enhance mass transfer, especially for large flow rate and feed-concentration operated under high reflux ratio.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":96404747,"openaccessinfo":{"externalids":{"MAG":"2006936926","ACL":null,"DOI":"10.12989\/MWT.2013.4.4.251","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim \nLeaf and air temperatures are seldom equal, but many vegetation models assume that they are. Land-surface models calculate canopy temperatures, but how well they do so is unknown. We encourage consideration of the leaf- and canopy-to-air temperature difference (\u0394\u03a4) as a benchmark for land-surface modelling and an important feature of plant and ecosystem function. \n \nLocation \nTropical SW China. \n \nTime period \n2013. \n \nMajor Taxa studies \nTropical trees. \n \nMethods \nWe illustrate diurnal cycles of leaf- and canopy-to-air temperature difference (\u0394\u03a4) with field measurements in a tropical dry woodland and with continuous monitoring data in a tropical seasonal forest. The Priestley\u2013Taylor (PT) and Penman\u2013Monteith (PM) approaches to evapotranspiration are used to provide insights into the interpretation and prediction of \u0394T. Field measurements are also compared with land-surface model results obtained with the Joint U.K. Land Environment Simulator (JULES) set up for the conditions of the site. \n \nResults \nThe \u0394T followed a consistent diurnal cycle, with negative values at night (attributable to negative net radiation) becoming positive in the morning, reaching a plateau and becoming negative again when air temperature exceeded a 'crossover' in the 24\u201329\u00a0\u00b0C range. Daily time courses of \u0394T could be approximated by either the PT or the PM model, but JULES tended to underestimate the magnitude of negative \u0394T. \n \nMain conclusions \nLeaves with adequate water supply are partly buffered against air-temperature variations, through a passive biophysical mechanism. This is likely to be important for optimal leaf function, and land-surface and vegetation models should aim to reproduce it.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":89823805,"openaccessinfo":{"externalids":{"MAG":"2738802217","ACL":null,"DOI":"10.1111\/GEB.12614","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The early Holocene climate in the North Atlantic region was rather unstable and three cold events superimposed upon a general warming took place during the earliest part of the Holocene: the Preboreal oscillation (11.3-11.1 ka BP), the Erdalen event (10.3-10.2 ka BP) and the 9.3 ka BP event (e.g. Dahl et al., 2002; Rasmussen et al. 2007). There is relatively little known about early Holocene tephrochronology in comparison to the Last Glacial\/Interglacial transition and the mid to late Holocene, although there is no reason to believe that Icelandic eruptions were less frequent during the early Holocene. The main focus of the present study is improve the dating and geochemical identification of early Holocene tephras on the Faroe Islands, using wiggle-match or Bayesian techniques for age-depth modelling and EMPA analyses for geochemical fingerprinting of tephras. Identification of tephras is also aided by XRF core scanning. While this method is still in its infancy, some promising results have been reported recently regarding the identification of cryptotephra in marine and lacustrine sediments. The Faroe Islands is an ideal area to test the method, since tephras ranging from basaltic to rhyolitic are abundant but usually not visible to the naked eye (Wastegard, 2002). We have investigated new cores taken in 2009 from previously studied sites and new sites with high sediment accumulation rates during the early Holocene. Results from the first analyzed peat and lake sediment cores from the Faroe Islands show that several previously unreported tephra horizons occur below the visible Saksunarvatn tephra dated to c. 10 300 cal. yr BP (Rasmussen et al. 2007). Two layers are rhyolitic, one dacitic and one basaltic. The XRF core-scanner data has been especially useful for identifying basaltic cryptotephra horizons.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":127445134,"openaccessinfo":{"externalids":{"MAG":"600530385","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to investigate which characteristics of the nocturnal melatonin signal, in addition to its duration, convey photoperiodic information to the reproductive axis. To achieve control over the pattern of circulating melatonin, male Syrian hamsters held under stimulatory long daylengths (16h light:8h dark) were pinealectomized to remove the principal source of circulating endogenous hormone and then fitted with chronic subcutaneous cannulae through which programmed infusions of melatonin solution or vehicle could be delivered. Experiment 1 tested whether long intervals between successive melatonin signals impaired the photoperiodic response. Animals which received a short day\u2010like melatonin infusion of 10 h duration once every 24 h (T = 24) for 6 weeks underwent gonadal atrophy. When the same number of signals (42) was delivered at a frequency of once every 32 h (T = 32), they were ineffective and animals remained gonadally active. Two infusion patterns were used to determine if the loss of response to 10 h signals given at T = 32 h was a consequence of the frequency per se or the long interval between signals (22 h). In the first, a 'chimaeric' signal which combined a long duration i.e. short day\u2010like 18 h melatonin signal with a short day\u2010like melatonin\u2010free interval of 14 h (combined signal T = 32 h) was able to induce significant, but only partial, gonadal atrophy. Second, when the 22\u2010h interval between 10\u2010h melatonin signals was interrupted by a short (2 h) melatonin pulse, significant but partial gonadal regression again occurred. Moreover, the response depended upon the timing of the 2 h pulse. When this fell early in the melatonin\u2010free interval, leaving a large portion of it intact, it had no effect on gonadal condition. In contrast, a pulse delivered in the middle of the interval, which divided it up into two short day\u2010like segments of 10 h each, was partially effective in restoring a short day response. The second experiment tested whether melatonin signals delivered at a high frequency would induce a photoperiodic response. A 10 h infusion delivered once every 24 h caused gonadal atrophy. The same melatonin infusion delivered at a periodicity of 20 h (T = 20) was also very potent as a short day stimulus. However, when 10\u2010h signals were delivered at the higher frequencies of once every 18 or 16 h, they were less effective. Only a minority of animals exhibited gonadal atrophy and overall the group means were not significantly different from those of saline\u2010infused controls, but were significantly greater than those of the 24 and 20 h groups. These data demonstrate that the photoperiodic response to the melatonin signal is sensitive to the frequency at which the signal is received. However, there is no evidence for a circadian basis to this sensitivity, nor a dependence upon the relationship between the endocrine stimulus and the light\u2010dark cycle, insofar as signals encountered at a non\u2010circadian period of 20 h are very effective. Moreover, the effectiveness of signals encountered at longer periodicities can be modified by manipulation of the uninterrupted duration of the interval free of melatonin, demonstrating a role in photoperiodic time measurement for the duration of the interval between signals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205344932,"openaccessinfo":{"externalids":{"MAG":"1977278976","ACL":null,"DOI":"10.1111\/j.1365-2826.1992.tb00342.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This prospective, randomised study compared the effectiveness of patient controlled epidural analgesia (PCEA) versus continuous epidural infusion (CEI) in providing pain relief post gynaecological surgery. Sixty six ASA I or II patients planned for gynaecological surgery via Pfannensteil incision under combined spinal epidural anaesthesia were recruited. They were randomised into two groups: Group A patients received PCEA while Group B patients received CEI. In the recovery area, both groups received an epidural combination of levobupivacaine 0.1% and fentanyl 2 \u03bcg\/ml. Group A patients were allowed demand bolus doses of 5 ml with a 20 minute lockout interval, while Group B patients had their epidural infusion initiated at 6 ml\/hour with increments as required to a maximum of 12 ml\/hour. Pain score and degree of motor blockade was assessed hourly in the first four hours and subsequently at four hourly intervals. Side effects were recorded at four-hourly interval. The total amount of analgesia, number of anaesthetic interventions and patient satisfaction was assessed 24 hours, postoperatively. There was no significant difference in pain score, total amount of analgesia, number of anaesthetic interventions and patient satisfaction. The degree of motor blockade and side effects were comparable between the groups. In conclusion, PCEA was comparable to CEI for pain relief after gynaecological surgery.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":53400047,"openaccessinfo":{"externalids":{"MAG":"2219065708","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\"Putting Faith in Partnerships\" addresses a major conceptual change in American domestic policy, begun by Reagan and now fully realized by the Bush administration: the shift of responsibility for social services from the federal government to states and communities. In this groundbreaking study of a politically controversial topic---the debut offering in Alan Wolfe's \"Contemporary Political and Social Issues\" series---author Stephen Monsma avoids overheated rhetoric in favor of a careful, critical analysis of the hard evidence on whether public-private partnerships really work. The book is based on in-depth studies of social service programs in Los Angeles, Chicago, Philadelphia, and Dallas. By examining public-private partnerships between government offices and nonprofit organizations, Monsma seeks to understand how these partnerships affect the balance between government's efforts to deal with social problems and the rights of individual citizens to control their own lives. \"Putting Faith in Partnerships\" answers many previously unanswered questions in what may be the most controversial public policy debate today: about the feasibility and wisdom of government agencies forming partnerships with private organizations to provide essential public social services.Stephen V. Monsma is Professor of Political Science at Pepperdine University. He has served as director of the Office of Quality Review in Michigan's Department of Social Services and is a widely recognized expert on the role of faith-based organizations in social service programs.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152288975,"openaccessinfo":{"externalids":{"MAG":"607196128","ACL":null,"DOI":"10.3998\/mpub.17561","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3998\/mpub.17561","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A new material on the genera Ultragryllacris gen. nov. and Capnogryllacris Karny, 1937 from Thailand, Laos and Cambodia is considered. Five new species and subspecies are described: U. pulchra sp. nov.; U. p. alboclypeata subsp. nov.; C. thaica sp. nov.; C. sakaerat sp. nov.; C. phaeocephala cambodiensis subsp. nov. Capnogryllacris s. l. is divided into two possible subgenera (Capnogryllacris s. str. and Dictyogryllacris Karny, 1937, stat. nov.) as a minimum; the former genera Borneogryllacris Karny, 1937, syn. nov., Marthogryllacris Karny, 1937, syn. nov. and Erythrogryllacris Karny, 1937, syn. nov. are treated as synonyms of the subgenus Capnogryllacris. Previously unknown female for C. khmerica Gorochov, 2003 is described; neotype for C. martha (Griffini, 1914 ), type species of Marthogryllacris, is designated; C. erythrocephala Gorochov, 2003, sp. ressur. and C. e. borealis Gorochov, 2003, stat. ressur. are restored from synonyms of C. martha and from species status, respectively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4308901,"openaccessinfo":{"externalids":{"MAG":"1530208773","ACL":null,"DOI":"10.11646\/zootaxa.4021.4.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: The purpose of this study was to quantify the growth of the various craniofacial and velopharyngeal structures and examine sex and race effects. Methods: Eight-five healthy children (53 white and 32 black) with normal velopharyngeal anatomy between 4 and 9 years of age who met the inclusion criteria and successfully completed the magnetic resonance imaging (MRI) scans were included in the study. Results: Developmental normative mean values for selected craniofacial and velopharyngeal variables by race and sex are reported. Facial skeleton variables (face height, nasion to sella, sella to basion, palate height, palate width) and velopharyngeal variables (levator muscle length, angle of origin, sagittal angle, velar length, velar thickness, velar knee to posterior pharyngeal wall, and posterior nasal spine to levator muscle) demonstrated a trend toward a decrease in angle measures and increase in linear measures as age increased (with the exception of posterior nasal spine to levator muscle). Only hard palate width and levator muscle length showed a significant sex effect. However, 2 facial skeleton and 6 velopharyngeal variables showed a significant race effect. The interactions between sex, race, and age were not statistically significant across all variables, with the exception of posterior nasal spine to posterior pharyngeal wall. Conclusion: Findings established a large age- and race-specific normative reference for craniofacial and velopharyngeal variables. Data reveal minimal sexual dimorphism among variables used in the present study; however, significant racial effects were observed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79648962,"openaccessinfo":{"externalids":{"MAG":"2781553600","ACL":null,"DOI":"10.1177\/1055665617718549","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1055665617718549","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper reported the effect of yeast extract and chitosan with combination of yeast extract on the growth and morphological changes and production of phenolics in the in vitro plantlets of Curcuma mangga . Yeast extract did not show any effect on the biomass and shoot proliferation of in vitro plantlets. However, the plantlets showed morphological abnormality when exposed to higher concentration of yeast extract (3.5 mgL -1 and above) supplemented into the culture medium. Plantlets cultured in media supplemented with 3.5 and 5.0 mgL -1 of yeast extract showed higher radical scavenging activity (RSA) which also indicated that stress induced by yeast extract might elicit the production of secondary metabolites which acted as free radical scavenger in 1,1-diphenyl-2- picrylhydrazyl (DPPH) assay. The plantlets treated with different concentration of chitosan combined with 3.5 mgL -1 of yeast extract affected the biomass of C. mangga . The plantlets that were cultured in media supplemented with 150 mgL -1 of chitosan combined and 3.5 mgL -1 of yeast extract showed higher RSA towards DPPH as compared to the other treatments. Kinetic of DPPH free RSA from C. mangga extract was considered slow as compared to quercetin and the correlation between total phenolic content and RSA was poor (R 2 = 0.2293) for yeast extract and (R 2 = 0.0373) for chitosan combination with yeast extract. This indicated that the presence of phenolic compounds in the extracts were not the major factor contributing to the anti-oxidative activity of C. mangga. Key words: Curcuma mangga, in-vitro, elicitor, phenolics, anti-oxidative activities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":56475565,"openaccessinfo":{"externalids":{"MAG":"2149678374","ACL":null,"DOI":"10.5897\/AJB10.1261","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cytotoxic T lymphocytes (CTLs) recognize foreign peptides presented at the cell surface bound to major histocompatibility complex class I (MHCI) molecules. Antigen recognition involves the binding of both T-cell receptor (TCR) and CD8 co-receptor to the same peptide-MHCI (pMHCI) ligand. Specificity is determined by the TCR, whereas CD8 mediates an effect on antigen sensitivity. Anti-CD8 antibodies have been used extensively in previous studies to examine the role of CD8 in CTL activation. However, it is unclear from the literature whether anti-CD8 antibodies per se are capable of inducing effector function. Here, we report on the ability of seven monoclonal anti-human CD8 antibodies to activate six human CTL clones with a total of five different specificities. Six out of seven anti-human CD8 antibodies tested did not activate CTLs. In contrast, one anti-human CD8 antibody, OKT8, induced effector function in all CTLs examined. Moreover, OKT8 was found to enhance TCR\/pMHCI on-rates and, as a consequence, could be used to improve pMHCI tetramer staining. The observed heterogeneity in the ability of anti-CD8 antibodies to trigger T-cell effector function provides an explanation for the apparent incongruity observed in previous studies and should be taken into consideration when interpreting results generated with these reagents. Furthermore, the ability of antibody-mediated CD8 engagement to deliver an activation signal underscores the importance of CD8 in CTL signalling.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":255656462,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.186.supp.113.28","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, comparison is made of the clinical with the anatomicopathological diagnosis of DIC. The review of the postmortem studies covered from March 1975 to March 1976 at Hospital de Pediatr\u00efa, C.M.N., and the following were the conclusions: Only in 40 of the cases, the clinical diagnosis of DIC was made. DIC was seen more frequently in the neonatal stage. The anatomicopathological diagnostic criterion is emphasized. Hemorrhages and thromboses predominated in lungs. Paracoagulation tests were not useful.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12593951,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gastrointestinal fistula patients may suffer from complicated intra-abdominal infection and sepsis with improper treatment, which is characterized by high mortality ranging from 20% to 60%, as well as high medical costs. Gastrointestinal fistula patients with complicated intra-abdominal infections are not often diagnosed early, and proper treatment remains an unsolved problem. Therefore it is a great challenge for surgeons to repair broken intestines under complicated intra-abdominal infection conditions and to repair ruptured intestines under conditions of severe abdominal adhesions and swelling of the intestinal wall and mesentery. After the open abdominal approach was first adopted to treat complicated intra-abdominal infection patients by Duff and Moffat in 1981, it gradually began to be used more widely. However, some investigators have reported that the open abdomen approach has not been effective in controlling controlled mortality, instead, it may even increase mortality. For this reason, the approach has only been used in large medical centers rather than having been widely popularized. In this review, the effect, timing, indications of open abdomen approach and the principles for the open abdominal wound management are summarized, and the reason for the various efficacy among different centers is also analyzed. We provide a new perspective for clinicians to manage the gastrointestinal fistula patients with complicated intra-abdominal infection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58608066,"openaccessinfo":{"externalids":{"MAG":"3024124980","ACL":null,"DOI":"10.3760\/CMA.J.ISSN.1671-0274.2018.12.021","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"-In this paper a simple expression is derived for the formula of variable quantizing step size. This formula can be used to improve the following ability of the discrete adaptive delta modulation codec. Then it is shown that the previously published formulas for video signal can be reduced to this expression. Next, clarifying the relation between the first-order difference \\xi of input signal and the mechanism of appearance of the slope overload noise by using this expression, the quantizing noise is classified into granular noise, the first class slope overload noise and the second class slope overload noise. Then these noises are simply expressed as a function of \\xi . Finally, using this result, the signal-to-noise ratios for sinusoidal input and Gaussian input are obtained and in consequence the utility of our simple analytical method is confirmed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":57835632,"openaccessinfo":{"externalids":{"MAG":"2081244634","ACL":null,"DOI":"10.1109\/TCOM.1977.1093803","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The two major discrepancies between the training and deployment conditions in automatic speech recognition are speaker and noise environment. Presented is a speaker adaptation method which is robust to noise environments in the framework of the basis-based technique. A training tensor composed of speaker-dependent models is decomposed by parallel factor analysis, which can produce the bases that are more robust and compact than those obtained by principal component analysis. Experimental results show that the proposed method performed as good as the eigenvoice in a clean environment and outperformed the eigenvoice in noise environments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":62741158,"openaccessinfo":{"externalids":{"MAG":"2083111809","ACL":null,"DOI":"10.1049\/EL.2011.0036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Humoral hypercalcemia of malignancy (HHM) can be caused by ectopic paraneoplastic production of 1, 25 dihydroxy vitamin D due to the hyperactivity of the 1 alpha-hydroxylase enzyme. We present a case of a 19-year-old female who was admitted with bilateral dysgerminomas and significant hypercalcemia. Hypercalcemia was initially managed medically and then resolved with the surgical resection of the tumors. Although most cases are attributed to a high parathyroid hormone-related peptide (PTHrP) and bone metastases, <1% of cases can result from paraneoplastic production of 1,25 dihydroxyvitamin D due to increased activity of 1 alpha-hydroxylase.This is one of the rare cases of hypercalcemia, which not only adds to the limited number of cases of hypercalcemia associated with dysgerminoma but also is the first case report showing that vitamin D can be a paraneoplastic factor itself.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208981165,"openaccessinfo":{"externalids":{"MAG":"2982889402","ACL":null,"DOI":"10.7759\/cureus.6097","PubMedCentral":"6901377","ArXiv":null},"license":null,"url":"https:\/\/www.cureus.com\/articles\/24316-hypercalcemia-due-to-paraneoplastic-production-of-125--dihydroxyvitamin-d-in-a-young-female-with-dysgerminoma.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper discusses the potential of the notions of reification and consensualization as developed by the theory of social representations as analytical tools for addressing the communication between the lay and scientific spheres. Social Representations Theory started by offering an over-sharp distinction between the reified and the consensual universes of which science and common sense, respectively, were presented as paradigmatic. This paper, however, suggests that the notions of consensual and reified can be considered as describing two distinct communicative formats: reification implying the use of arguments which establish prescriptions for representations and action, and consensualization relying on arguments which recognize the heterogeneity of representation and action. We illustrate this proposal through the analysis of a case in which the expert and the lay spheres of a Lisbon neighborhood opposed each other regarding the new laws of public participation in community matters. This analysis showed how reification and consensualization can be used as discursive strategies by both spheres. The implications of the use of reification and consensualization as communicative formats and how they may depend on several power resources and have different impacts on change are discussed.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":52888754,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44666695,"openaccessinfo":{"externalids":{"MAG":"1967045317","ACL":null,"DOI":"10.1021\/np900336f","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc2754322?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"AIM\nTo determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.\n\n\nMATERIALS AND METHODS\n312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27.2%) patients had no response to treatment. After excluding obstructive CP, celiac disease, decompensation of diabetes (DD), ischemic and microscopic colitis, small intestinal bacterial overgrowth (SIBO) as a cause of abdominal pain and intestinal dysfunction, a group of 54 patients with exacerbation of CP and IBS-like syndrome was isolated. They were divided into 2 groups: group 1 persons receiving with standard treatment of CP ciprofloxacin in a dose of 500 mg 2 times a day for 10 days (26 patients), group 2 rifaximin 400 mg 3 times a day for 10 days (28 patients). The dynamics of clinical picture, biocenosis indices, endoscopic, morphological features of the colon, interleukin-2 (IL-2), IL-6, IL-8 concentration in the colon mucosa (CA) were evaluated.\n\n\nRESULTS\nIBS-like syndrome was determined in 54 (63.5%) patients with prolonged (more than 4 weeks) exacerbation of CP. A modification of therapy is proposed with the results of clinical and instrumental, laboratory, bacteriological studies. 68% of patients with exacerbation of CP, receiving in addition to the standard regimen rifaximin, achieved clinical improvement, normalization of intestinal biocenosis, reduced concentrations of cytokines in tissues, reducing signs of chronic inflammation in the colon mucosa with reducing concentrations of IL-2, IL-6, IL-8 in colon mucosa (p0.05).\n\n\nCONCLUSION\nExacerbation of CP, resistant to standard therapy, may be associated with the formation of IBS-like syndrome. The inclusion of rifaximin in the complex therapy of prolonged exacerbation of CP contributes to the relief of intestinal dysfunction, abdominal pain of intestine, improves biocenosis, reduces inflammatory modifications, and reduces the concentration of cytokines in the colon mucosa.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219790270,"openaccessinfo":{"externalids":{"MAG":"3032129512","ACL":null,"DOI":"10.26442\/00403660.2020.02.000518","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/download\/33903\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Injuries in the orbital region have profound functional as well as aesthetic implications. Treatment of orbital fractures remains one of the most controversial issues in maxillofacial trauma with regard to the classification, diagnosis, surgical approach and treatment. Purpose: This study evaluated and compared the efficacy of two most commonly applied approaches the preseptal transconjunctival with lateral canthotomy and the subciliary approach for the treatment of infraorbital floor and rim fractures. Patients And Methods: Twenty patients reported to G.D.C.R.I. Bangalore who suffered infraorbital floor and rim fractures, were randomly divided into two groups with 10 patients in each group. In one group, anatomic reduction and reconstruction was done with preseptal transconjunctival approach with lateral canthotomy and in the other group with subciliary approach. Results: In transconjunctival group, transient entropion was significant (30%). In subciliary group, transient ectropion was significant (30%). Conclusion: In our study, preseptal transconjunctival approach with lateral canthotomy and subciliary skin-muscle flap approach for the open reduction and rigid fixation of infraorbital floor and rim fractures had showed less morbidity and lesser risk of complications and given satisfactory results.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6269840,"openaccessinfo":{"externalids":{"MAG":"2067821671","ACL":null,"DOI":"10.4103\/2231-0746.101338","PubMedCentral":"3591055","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/europepmc.org\/articles\/pmc3591055","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract : When major natural disasters strike the United States, the nation's active military forces are frequently called upon to augment the relief efforts of the affected states' National Guard units. Currently, Title 10, United States Code, prohibits the President from ordering the activation of Selected Reserve units or personnel for participation in domestic disaster relief operations. Reductions in the overall active strength, along with changes in the force structure of active forces and Reserve Components, increase the potential that the types of active forces most needed in domestic disaster relief may not be available when a major disaster strikes. This study analyzes the advantages and disadvantages of enabling the President to access the Selected Reserves for participation in domestic disaster relief operations. The study concludes that the best course of action for the Secretary of Defense is to recommend that the President pursue legislation to amend Title 10 to permit involuntary activation of Selected Reserve units and individuals under a Presidential Selected Reserve Call-up for domestic disaster relief operations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107820763,"openaccessinfo":{"externalids":{"MAG":"13772072","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. Challenging Developments in Urban China and Emerging Theoretical Perspectives Mark Y. Wang, Pookong Kee and Jia Gao 2. Urbanisation and \"Home Protection\" in Contemporary China Xiaoyang Zhu 3. The Decline of Rural-Urban Divide and Diminishing Significance of Hukou Zhanxin Zhang 4. The Development Zone and Urban Spatial Restructuring: Significance, Process and Problems Guo Zheng 5. Restructuring Rust-belt Urban Economy: Northeast China Experience He Li 6. Are Migrants Better or Worse than Locals in China's Urban Labour Market? Zhiming Cheng and Fei Guo 7. The Contours of Rural Domestic Workers' Agency and Action within the Urban Workplace Mei-Ling Ellerman 8. Home Perception and Housing Strategy of Rural-Urban Migrants in China Yunxian Wang 9. Social Distance between Migrant Workers and Citizens: An Analysis of Attitude, System Identification & Distance Guoxian Lu 10. Aviator Families' Social Connections: School Migrants and the Accompany-Study-Mothers in Urban China Jordan Brown 11. Residential Environment in Chinese Urban Gated Community: Assessment of Outdoor Space Usage Caiwei Wu, Mark Y. Wang and Yongping Wei 12. Beijing Gated Community: Self-governance Ying Wu 13. The Impact of Urban Form on Household Carbon Emissions: A Case Study on High and Low Carbon Communities in Beijing Bo Qin 14. Can a Chinese City Reduce its Wastewater Discharge? Shenyang Economic Zone as a Case Ruiling Han, Lianjun Tong, and Yanji Ma","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":166742072,"openaccessinfo":{"externalids":{"MAG":"1721707388","ACL":null,"DOI":"10.4324\/9781315818733","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Two case studies of students from California School for the Blind studying artworks in museums and on the Web are discussed. The analysis focuses on the traditional understanding that unreachable artworks in the museum are deciphered by non-intellectual elites primarily from the perspective of visual perception and museums are simple vessels of art, as contended by Ernst Gombrich and Pierre Bourdieu, and that exclusion is either passive or active. It is also argued that there is a bridge between sensing an object and understanding it that is beyond perceptions. The article concludes that the two students featured in the case studies were more likely to be passively rather than actively excluded from unreachable and two-dimensional artworks, and that they could still develop a symbolic intellectual and emotional connection with these artworks and the museum through verbal descriptions and being in their presence.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55466486,"openaccessinfo":{"externalids":{"MAG":"2181834778","ACL":null,"DOI":"10.1177\/0264619613514238","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/create.canterbury.ac.uk\/14192\/1\/BJVIArticle_Edits_November2013.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We present an experimental study comparing various Recurrent Neural Network architectures for the task of Vulnerable Road User (VRU) motion trajectory prediction in the intelligent vehicle domain. Making use of temporal motion cues and visual appearance features, we design multi-cue RNN-based architectures with dedicated optimization process to predict future moving trajectories from historical consecutive frames. Experiments are performed on image sequences recorded from on-board a moving vehicle and public tracking datasets. In particular, the Tsinghua-Daimler Cyclist Benchmark (TDCB) has been augmented with additional annotations (vari-ous VRU types) to support the evaluation of object tracking approaches and trajectory prediction methods. This newly introduced dataset is termed TDCB-Track. We demonstrate the effectiveness of the proposed RNN architectures on the public MOT16 dataset and the TDCB-Track dataset. We show that the proposed approaches outperform simpler baseline methods and stay ahead with the state-of-the-art.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":201812804,"openaccessinfo":{"externalids":{"MAG":"2970828890","ACL":null,"DOI":"10.1109\/IVS.2019.8814275","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND PURPOSE\nInappropriate neural control of the quadriceps femoris muscle group has been implicated in patellofemoral pain syndrome (PFPS). This study investigated the timing of initial electromyographic (EMG) activity of the vastus medialis oblique muscle (VMO) and the vastus lateralis muscle (VL) in asymptomatic subjects and subjects with PFPS during reflex and voluntary muscle activity.\n\n\nSUBJECTS\nFifteen symptomatic subjects (SYMP group) (9 with bilateral symptoms) and 12 asymptomatic subjects (ASYMP group) participated. Both knees were tested in the ASYMP group and only the symptomatic knees were tested in the SYMP group, resulting in a total of 24 data sets from each group.\n\n\nMETHODS\nElectromyographic data were recorded from the VMO and VL under three conditions: reflex knee extension (RFLX) elicited by a patellar tendon tap, and active knee extension in non-weight-bearing (NWB) and weight-bearing (WB) situations. For each condition, EMG activity onset times for the VMO and VL were determined from ensemble averages of four trials.\n\n\nRESULTS\nThere were no differences between the SYMP and ASYMP groups with respect to the relative timing of initial VMO and VL activity under any of the three conditions tested. Mean timing differences for both groups were less than 0.25 milliseconds under reflex conditions and less than 4 milliseconds for active knee extension under both WB and NWB conditions.\n\n\nCONCLUSION AND DISCUSSION\nThese findings contradict a previous report of differences in reflex timing related to PFPS. Differences in the relative timing of onset of EMG activity of the VMO and VL during voluntary knee extension were not significant between SYMP and ASYMP groups, and were not related to the relative timing differences observed during reflex testing.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":14664464,"openaccessinfo":{"externalids":{"MAG":"2264632321","ACL":null,"DOI":"10.1093\/PTJ\/75.9.813","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This research aims to analyze mixed methods graduate thesis studies completed between 2010 and 2020 in special education programs in Turkey. The literature scan has yielded 26 studies. A qualitative research method, analytical research design has been employed in this study. Research data has been obtained from documents \u2013 namely the graduate thesis studies \u2013 and analyzed through content analysis carried out following fundamental stages of mixed methods research as proposed in the literature. These stages served as themes in this study: 'Determining the research aim and research questions', 'Selecting a mixed methods research design', 'Explaining the rationale for the mixed methods approach', 'Sampling', 'Collecting the data', 'Analysing the data', 'Integrating, interpreting and reporting the data', 'Researcher competencies and roles' and 'Ethics'. The limitations observed in the methodology and reporting of the thesis studies have suggested that the quality standards of mixed methods research are not reflected on the studies. These limitations include confusion in terminology, lack of explanation as to why the method and the design have been employed, restricted validity and reliability, and lack of integration through blending quantitative and qualitative data. In summary, despite the increase in the number of mixed methods research studies in special education has contributed to the field, it is still debatable whether the philosophical perspective behind the method and its strong suits can be reflected on the studies.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1,"unknown":2}},"corpusid":246671787,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.14689\/enad.29.1","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/enadonline.com\/index.php\/enad\/article\/download\/931\/24","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Summary We have examined in unstimulated and thrombin-stimulated human and rabbit platelets the localization and behavior of aequorin loaded by a variety of published methods. When platelets were suspended at 37\u00b0 C in Tyrode-albumin medium containing 2 mM Ca2+ and apyrase, we found with all preparations that total aequorin revealed by addition of Triton X-100 decreased by more than 50% over one hour. Incubation in the presence of 5 mM EGTA followed by addition of Ca2+ to restore the concentration to 2 mM showed that some aequorin had entered the medium; subsequent addition of Triton X-100 showed that the increase in aequorin in the medium matched the decrease in aequorin in the platelets, such that total aequorin remained unchanged. However, comparison of aequorin in platelets incubated in media with and without Ca2+ showed a larger decrease in platelets incubated in the presence of Ca2+; this finding may indicate the presence of an intracellular pool of Ca2+ which is more dependent on external Ca2+. Stimulation of platelets with thrombin in the presence of EGTA resulted in a smaller luminescent signal than in the presence of Ca2+. Subsequent addition of Ca2+ to 2 mM in the platelet suspension that originally contained EGTA or to its supemate (after centrifugation of the platelet suspension), resulted in a larger luminescent signal compared with controls, indicating that stimulation of the platelets had increased loss of the aequorin into the medium. Together, these results indicate that a portion of the aequorin luminescent signal in stimulated platelets suspended in the presence of Ca2+ is due to loss of aequorin into the medium and thus results obtained under these conditions must be regarded with caution. The signal in platelets suspended in the absence of Ca2+ does appear to arise from aequorin inside the platelets.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":23430885,"openaccessinfo":{"externalids":{"MAG":"2442720889","ACL":null,"DOI":"10.1055\/s-0038-1649674","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Defecation time, fecal amount, and water content of feces of sika deer, Cervus nippon, were studied for two deer kept in large-scale enclosures. The deer were observed eight times for 24 hours, and all the feces were collected immediately after defecation. The defecation interval varied considerably with a median of 21 min. The number of defecations per 24 hours ranged from 9 to 49. The number of fecal pellets per deer per 24 hours showed a seasonal variation with a mean of 1276. As a parameter for the fecal pellet count method, our result did not conflict seriously with the number, 1010\/deer\/day, obtained from captive deer (Takatsuki et al. 1981) on the average basis. On the other hand, its seasonal variation has to be considered when a deer population is censused with pellet count method. Water content of fecal pellet varied widely with apparent response to precipitation within three days before the defecation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86161154,"openaccessinfo":{"externalids":{"MAG":"2128055493","ACL":null,"DOI":"10.3106\/1348-6160-33.4.143","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A real-time speaker-dependent connected word recognition system with speaker adaptation is described. Cepstral analysis is performed using a digital signal processor. The system generates word candidates by continuous dynamic time warping (DTW) between input speech and word templates. With DTW-LSI chips, the matching between an input pattern and 500 word templates can be carried out in real time. Sentence syntax rules are represented by a finite-state network model, and a real-time search is performed using parallel processors. The system can handle an 8000-word (maximum) vocabulary task, if focus control is performed and the words to be recognized simultaneously are in groups of less than 500. The system has a speaker adaptation function based on vector quantization. The recognition system has been evaluated in a 191-word vocabulary expert system for a nuclear power plant and achieves sentence-recognition accuracies of 94.7% and of 93% with the speaker adaptation. The system can realize a speech dialogue expert system for practical use.<>","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":62580136,"openaccessinfo":{"externalids":{"MAG":"2112247251","ACL":null,"DOI":"10.1109\/ICPR.1990.119356","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Due to advances in techniques for digital ecosystems and cyber engineering, users can now submit queries to search for inclusive information from different Web objects using mobile handheld devices such as smartphones in many real-life situations. As these mobile devices are not necessarily connected to the Internet all the time, users usually want to be able to get information such as e-mail, news, weather, and Web feed as soon as their mobile devices are connected to the Internet. However, these mobile devices have relatively limited resources. In this paper, we focus on mobile web navigation. Specifically, we use rooted directed trees, which enable users to access valuable information from the highly ranked and relevant Web sites, for answering user-inclusive queries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2015-06":1,"2013-20":1,"2015-11":1}},"corpusid":37212778,"openaccessinfo":{"externalids":{"MAG":"2100954553","ACL":null,"DOI":"10.1109\/TIE.2010.2050292","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Acrodermatitis enteropathica is an inborn error of zinc metabolism which is inherited as an autosomal recessive disorder. It is characterized by periorificial -oral, anal and genital-, acral dermatitis, anorexia, diarrhea, behavioral\/mental changes, neurological disturbances, alopecia and secondary bacterial\/fungal infections.The aim of this study was to determine the pattern frequency of these abnormalities in children with acrodermatitis enteropathica. This study comprised 16 patients attending the Dermatology Department at Jinnah Post Graduate Medical Centre, Karachi during the last twelve months. Age, sex, nationality, age at the onset of first symptoms, height, weight and family history were recorded. Dermatitis and diarrhea were found in all 16 patients i.e. 100%, 11 (69%) patients had bacterial infections, 15 (94%) cases had Candida infection, 4 (25%) had dermatophyte infections, 4 (25%) had alopecia, behavior and mental changes were seen in 3 (18.75%) patients and 3 children (18.75%) had nail dystrophies. Eye changes were observed in 2 (12.5%) patients. In all cases, low serum zinc levels were documented, 8 children had low alkaline phosphatase while 7 were found to be anemic. Early diagnosis of this condition results in complete healing and reversal of symptoms. However, an early diagnosis and management of this condition require teamwork and thus consultation with pediatricians, dermatologists, pediatric gastroenterologists and nutritionists may be necessary.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":164376382,"openaccessinfo":{"externalids":{"MAG":"2944331541","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Orobanche cumana is an holoparasite and thus totally dependent on sunflower for fixed carbon. Initial stages of the infection occur in the first weeks after sowing and are critical for the establishment of a continuum between the host and the parasite vascular system. From that moment the parasite obtains its supply of water, mineral nutrients, and assimilates from the host plant. Alterations of plant metabolism can be detected using remote sensing techniques for detection of fluorescence emitted by plants. One of these indirect techniques is multicolour fluorescence imaging. In this work, we assessed the early infection of sunflower by O. cumana using multicolour fluorescence imaging and we inferred physiological processes affected in sunflower plants infected by the parasite. Ten germinated seeds of the inbred line NR5 were inoculated with population LP2013 of O. cumana. The same number of not inoculated seeds was used as control. Sunflower was planted in pots with soil mixture and grown in greenhouse at 12\u201322\u00b0C for 6 weeks. Multicolour fluorescence imaging was conducted 3, 4, and 5 weeks after inoculation. The two first pairs of fully expanded leaves of each sunflower plant were imaged, and, for each measure date, five fluorescence variables in inoculated plants were compared to those in the control. Three weeks after inoculation, when symptoms of infection were still not observed, decreased levels of blue and green fluorescence and increased far-red fluorescence were observed in leaves of the inoculated plants. At 4 and 5 weeks after inoculation, when inoculated plants displayed symptoms of infection by O. cumana, differences in fluorescence between inoculated plants and the controls were the same and statistically supported. These results are consistent with an increase in total chlorophyll content of sunflower plants infected by O. cumana, and a decrease in the accumulation of secondary metabolites, both related to the need of higher photosynthetic activity to supply the parasite with photosynthate. Biochemical mechanisms underlying alterations in photosynthesis must be further investigated. The results obtained showed that multicolour fluorescence imaging can be used to detect fluorescence differences in inoculated sunflower as early as 3 weeks after inoculation. Therefore, this technique can be used as a diagnostic tool for early detection of genotypes of sunflower which are susceptible or resistant to O. cumana.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":59392697,"openaccessinfo":{"externalids":{"MAG":"1980927456","ACL":null,"DOI":"10.1515\/helia-2014-0015","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/helia-2014-0015\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Administration of hypothalamic peptides has been reported to induce behavioral changes and to modify neurological functions such as locomotor activity and learning. Somatostatin (SS) and growth hormone-releasing factor (GRF) exert opposite effects on anterior pituitary secretion. Similarly, at the central nervous system (CNS) level, SS and GRF display antagonistic actions on behavioral parameters. The authors were able to confirm these effects in male Wistar rats by means of a computerized electronic maze measuring locomotor activity and learning. SS concentration is reduced in specific areas of the CNS in patients with late onset of senile dementia of the Alzheimer's type (SDAT). In early onset SDAT a GRF test elicits a growth hormone response much greater than that observed in normal controls of the same age or in patients with late onset SDAT. Thus, administration of GRF to patients with early onset SDAT has been followed by a significant improvement in locomotion, appetite, mental performance and social interaction. A possible therapeutic role of GRF in the management of patients with dementia remains to be explored.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20471391,"openaccessinfo":{"externalids":{"MAG":"2082767574","ACL":null,"DOI":"10.1159\/000180988","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Anxiety and depression in Swedish primary care has rarely been studied. A national sample of 131 primary care physicians and their 1,348 patients during one day in September 2001 responded to questionnaires on somatic disease, social conditions, treatments, and symptoms of anxiety and depression. A total of 23% of the patients had generalized anxiety and\/or depression with or without receiving treatment, i.e. the most common category following musculoskeletal conditions. The appointment was caused by anxiety in 7.1% of the patients, depression in 8.5%, and insomnia in 11%. This group of patients did not deviate much in terms of somatic and social conditions, except being younger. Doctors were confident in diagnosing and treating them. Five key questions can be used in primary care to screen for these common psychiatric conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23128643,"openaccessinfo":{"externalids":{"MAG":"2413988700","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Myxofibrosarcoma (MFS) is one of the most common sarcomas of adults, and includes lesions ranging from low to high grade based on increasing cellularity, nuclear pleomorphism, and mitotic activity. We present an unusual case of MFS, which initially showed features of a pleomorphic hyalinizing angiectatic tumor (PHAT), a rare soft-tissue tumor considered benign in the WHO classification. The initial lesion showed a subcutaneous proliferation of spindled to polygonal eosinophilic cells with striking cellular pleomorphism, set in a myxoid to sclerotic stroma with prominent hyalinized and angiectatic vasculature, classic characteristics of PHAT. Rare mitotic figures were identified. The preliminary diagnosis of PHAT was confirmed by a consultant expert soft-tissue pathologist. Four months after the initial surgery, local recurrence was noted. The recurrent tumor demonstrated findings of a high-grade MFS, with a diffuse and cellular proliferation of atypical spindle cells set in a prominent myxoid stroma. Multiple mitoses, including atypical ones, were present. In light of these findings, the original specimen was reexamined and the initial diagnosis was amended to MFS. MFS may mimic or be confused with several benign soft-tissue lesions. Cases mimicking PHAT have not been previously reported. We describe a unique case of a high-grade MFS that initially showed characteristic features of a PHAT, to illuminate the fact that MFS may rarely arise in, or have areas that masquerade as, PHAT. It is also conceivable, although speculative, that at least some cases of PHAT, currently considered a benign tumor by the WHO, may actually represent or evolve into a unique form of MFS of low malignant potential.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34835446,"openaccessinfo":{"externalids":{"MAG":"2085512587","ACL":null,"DOI":"10.1097\/01.dad.0000171605.48186.31","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An efficient new method was developed to synthesize multisubstituted 4,5-dihydro-1H-azepine derivatives through the gold-catalyzed reaction of two molecules of propargylic esters with one molecule of alkyl azide. It was proposed that vinyl gold carbenoid, in situ generated from propargylic ester through gold-catalyzed 1,2-rearrangement, was trapped by alkyl azide to give vinyl imine intermediate. These, in turn, could undergo a formal [4 + 3] cycloaddition with another molecule of vinyl gold carbenoid to afford the desired azepine product.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38103997,"openaccessinfo":{"externalids":{"MAG":"2010276596","ACL":null,"DOI":"10.1021\/jo300667a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nOur study was undertaken to better assess the circumstances of perforation during colonoscopy.\n\n\nMETHODS\nAll cases observed in our department between 1978 and 1994 were computer recorded. During this period, 5,822 colonoscopies were performed, including 872 with at least one polypectomy.\n\n\nRESULTS\nAll perforations occurred during colonoscopies performed under anaesthesia (n = 3,373 vs 2,449 without anaesthesia). There were a total of 15 observations of colonic perforations, 1 perforation in 388 colonoscopies. Ten perforations occurred during diagnostic colonoscopies (0.20%), 5 after polypectomy (0.57%). Eight of 10 perforations complicating diagnostic colonoscopies occurred below an impassable stricture. Two patients died from this complication (0.03% of all colonoscopies).\n\n\nCONCLUSIONS\nOur study suggests that endoscopic exploration of colonic stricture, in addition to anaesthesia, increases the risk of colonic perforation.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":29618628,"openaccessinfo":{"externalids":{"MAG":"70872447","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Plasminogen activator is usually detected indirectly through the lysis of radioiodinated fibrin. Here, it was investigated whether the fibrinolysis test may be substituted by a photometric assay using a synthetic chromogenic substrate (H-D-Val-Leu-Lys-p-nitroanilide; S-2251). Supernatants from cultured murine macrophages served as source of plasminogen activator. It is shown that under standard conditions the photometric assay is about twice as fast and 2--4-fold more sensitive than the fibrinolysis assay. Furthermore, reproducibility of the photometric test was found within 1.5--3.5% standard deviation compared to the fibrinolysis test which was found between 10--20% standard deviation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22276159,"openaccessinfo":{"externalids":{"MAG":"2319917975","ACL":null,"DOI":"10.1515\/BCHM2.1980.361.2.1251","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dietary fiber may be partly responsible for the lower bioavailability of carotenoids from food than from purified supplements. Due to the lack of detailed information available, we investigated the effects of different kinds of dietary fiber on the absorption of carotenoids and alpha-tocopherol. Six healthy young women received an antioxidant mixture consisting of beta-carotene, lycopene, lutein, canthaxanthin and alpha-tocopherol together with a standard meal. The meal did not contain additional dietary fiber or was enriched with pectin, guar, alginate, cellulose or wheat bran (0. 15 g. kg body weight(-1)). The increases in plasma carotenoid and alpha-tocopherol concentrations were followed over 24 h, and the areas-under-curves (AUC(24h)) were calculated. The mean AUC(24h) of beta-carotene was significantly (P < 0.05) reduced by the water-soluble fibers pectin, guar and alginate with a mean decrease of 33-43%. All tested fibers significantly reduced the AUC(24h) of lycopene and lutein by 40-74% (P < 0.05). The dietary fiber effect on the AUC(24h) of canthaxanthin was almost significant (P = 0.059) and there was no effect on the AUC(24h) of alpha-tocopherol. We conclude that the bioavailability of beta-carotene, lycopene and lutein given within a mixed supplement is markedly reduced by different kinds of dietary fiber.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4452561,"openaccessinfo":{"externalids":{"MAG":"2163066828","ACL":null,"DOI":"10.1093\/JN\/129.12.2170","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Automatic program repair (APR) has recently gained attention because it proposes to fix software defects with no human intervention. To automatically fix defects, most APR tools use the developer-written tests to (a) localize the defect, and (b) generate and validate the automatically produced candidate patches based on the constraints imposed by the tests. While APR tools can produce patches that appear to fix the defect for 11\u201319% of the defects in real-world software, most of the patches produced are not correct or acceptable to developers because they overfit to the tests used during the repair process. This problem is known as the patch overfitting problem. To address this problem, I propose to equip APR tools with additional constraints derived from natural-language software artifacts such as bug reports and requirements specifications that describe the bug and intended software behavior but are not typically used by the APR tools. I hypothesize that patches produced by APR tools while using such additional constraints would be of higher quality. To test this hypothesis, I propose an automated and objective approach to evaluate the quality of patches, and propose two novel methods to improve the fault localization and developer-written test suites using natural-language software artifacts. Finally, I propose to use my patch evaluation methodology to analyze the effect of the improved fault localization and test suites on the quality of patches produced by APR tools for real-world defects.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":232371369,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ICSE-Companion52605.2021.00134","PubMedCentral":null,"ArXiv":"2104.07851"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Targeted, stimulus-responsive DNA nanogels hold considerable promise for cancer therapeutics. To expand their functionality including thermoresponsiveness, here, multifunctional DNA nanogels are developed for potential application toward cancer-targeted delivery and stimuli-responsive release of cancer therapeutics. Three types of functionalized DNA nanobuilding units are formed into DNA nanogels of \u2248200\u00a0nm via sequence-dependent self-assembly. The sequence-dependent assembly of nanobuilding units is precisely designed for controlled assembly and thermal disassembly at physiological temperatures. The supramolecular structure exhibits multifunctionalities including temperature-induced disassembly, aptamer-mediated cancer cell targeting, and light-triggered temperature increase. The nanogels support co-loading of cancer therapeutics including anti-sense oligonucleotides and doxorubicin along with stimuli-responsive release of loaded drugs through temperature-responsive structural disassembly and pH-responsive deintercalation. The nanogels exhibit efficient aptamer-mediated cancer-specific intracellular delivery and combinational anticancer effects upon light triggering. The developed DNA nanogels, thus, constitute potential noncationic nanovectors for targeted delivery of combinational cancer therapeutics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":227156525,"openaccessinfo":{"externalids":{"MAG":"3107059233","ACL":null,"DOI":"10.1002\/marc.202000457","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Time restricted feeding (TRF) refers to dietary interventions in which food access is limited during a specific timeframe of the day. TRFs have proven useful in improving metabolic health in adult subjects with obesity. Their beneficial effects are mediated, in part, through modulating the circadian rhythm. Nevertheless, the translation of these dietary interventions onto obese\/overweight children and adolescents remains uncharacterized. The objective of this study is to explore the feasibility of temporal dietary interventions for improving metabolic health in the context of childhood obesity. Methods: We have previously developed a mouse model of early adiposity (i.e., childhood obesity) through litter size reduction. Mice raised in small litters (SL) became obese as early as by two weeks of age, and as adults, they developed several obesity-related co-morbidities, including insulin resistance, glucose intolerance and hepatic steatosis. Here, we explored whether two independent short-term chrono-nutritional interventions might improve metabolic health in 1-month-old pre-pubertal SL mice. Both TRFs comprised 8 h feeding\/14 h fasting. In the first one (TRF1) Control and SL mice had access to the diet for 8 h during the dark phase. In the second intervention (TRF2) food was available during the light:dark transitions. Results: TRF1 did not alter food intake nor ameliorate adiposity in SL-TRF1. In contrast, SL-TRF2 mice showed unintentional reduction of caloric intake, which was accompanied by reduced total body weight and adiposity. Strikingly, hepatic triglyceride content was completely normalized in SL-TRF1 and SL-TRF2 mice, when compared to the ad lib-fed SL mice. These effects were partially mediated by (i) clock-dependent signals, which might modulate the expression of Pparg or Cpt1a, and (ii) clock-independent signals, such as fasting itself, which could influence Fasn expression. Conclusions: Time-restricted feeding is an effective and feasible nutritional intervention to improve metabolic health, namely hepatic steatosis, in a model of childhood obesity. These data open new avenues for future safe and efficient chrono-nutritional interventions aimed to improve metabolic health in children with overweight\/obesity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":239474413,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/nu13103579","PubMedCentral":"8538558","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6643\/13\/10\/3579\/pdf?version=1634798420","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background Hypothermia induced by whole-body cooling (WBC) and\/or selective head cooling reduces brain injury after hypoxia-ischemia in newborns. Despite differences in approach (head cooling vs. total body cooling), there is a general agreement that hypothermia improves outcomes of moderately asphyxiated infants, decreasing the combined outcome of death and neurologic dysfunction from 60 to 45%. Subsequently, the search for adjuvant therapies that may provide long-lasting neuroprotection was mandatory. Aim of the present work The present study aimed to evaluate the short-term effects of erythropoietin (Epo) as a neuroprotective agent in adjunction with WBC to treat newborn infants with hypoxic-ischemic encephalopathy (HIE). Participants and methods This is a true interventional randomized controlled hospital-based study. A total of 33 full-term and late preterm newborn infants, delivered at El-Shatby Alexandria University Maternity Hospital, Egypt, were enrolled in the study. They fulfilled the criteria of HIE and received WBC during the first 6\u2009h of life, in addition to the standard intensive care measures. Of the 33 studied babies, 11 received 500 IU\/kg Epo every other day for 2 weeks as adjunctive therapy to WBC. Results The Epo plus WBC group (group I) had a significantly shorter period of hospital stay in comparison with the other group managed by WBC solely (group II), [mean hospital stay in days\u00b1SD: 6.20\u00b12.39 and 8.40\u00b13.94, respectively (P=0.039)]. The incidence of seizures was insignificantly lower among babies in group I. Extensive white and gray matter brain lesions were observed more among group II neonates, although the difference was statistically insignificant. Clinical and neurological improvements, as guided by Thomson score, were better achieved among group I babies, despite the difference being statistically insignificant. Conclusion Epo as an adjunctive therapy with WBC for treating asphyxiated neonates is a safe mode of therapy, which significantly shortens the period of hospital stay as well as it (marginally) improves their short-term outcome, both radiologically and clinically. WBC plus Epo lowers the rate of occurrence of clinically detectable seizures in the 1st week of life among asphyxiated neonates.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":57858655,"openaccessinfo":{"externalids":{"MAG":"2794370451","ACL":null,"DOI":"10.4103\/AJOP.AJOP_14_17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper examines the place of amateur imagery and citizen photojournalism in Time magazine's photoblog, Lightbox. If user-generated content has been seen as a threat by professional photojournalists in the last decade, Lightbox offers a paradigmatic example to understand if the visual elite still has a dominant status in the decision-making processes of news production. This paper, therefore, explores how citizen imagery is shaping and challenging a photojournalistic culture still influenced by criteria of excellence, legitimacy, and authority. Managed by professional photo editors, Lightbox has included a variety of sections which emphasize new, original work by professional photographers as well as weekly news reviews that sometimes incorporate amateur photography. Through a visual analysis of amateur imagery in Lightbox's sections and a textual examination of the editors' discussions on citizen photojournalism, this paper analyzes how the photoblog is adapting to the shift towards a digital age of innovation and hybridity. The results show that photo editors apply strategies to delimit citizen productions by very rarely selecting them and avoiding specific mention of the amateur nature of such images. Moreover, they underline that hybridity is understood not as multimodal content and co-creative processes between professional and amateur incorporations, but rather as professional and creative practices, for example by highlighting innovative photographers who use cell phone imagery and photo-sharing websites. While this paper interrogates the new careers in photography of amateurs turned professionals, it also shows how digital platforms emphasize the photographers' personal initiatives over usual gatekeeping processes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":143146251,"openaccessinfo":{"externalids":{"MAG":"1868577181","ACL":null,"DOI":"10.1080\/21670811.2015.1034524","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"[Invited Talk, Annual Meeting of the American Association for the Advancement of Science, February 21, 1977. Dr. von Hippel is Chairman of the AAAS Committee on Scientific Freedom and Responsibility's Subcommittee on Professional and Social Responsibility of the Scientist.]","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42028289,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ts.1977.6500313","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"During the course of aging, the balance between intrarenol hormones is disturbed. These age-related changes are well documented for the vasoconstrictor reniri-ariglotensin system, but comparable information on the renal kallikrein-klnin system Is not yet available. The status of the kallikrein-kinin system was assessed by (1) kalllkreln activity, measured by RIA; (2) maximum binding site density (Bmax) and affinity (Kd) of nonapeptide bradykinin (BK)-2 receptor, estimated by binding assays; (3) expression of BK2-re-ceptor mRNA, detected by reverse transcription-poly-merase chain reaction (RT-PCR) using specific BK2-oligonucleotide primers. These parameters were determinated on renal glomerull of 3-, 5-, 8-, (cid:1)2- and 38-wk-old normotensive rats. Kallikreln activity increased from 3.2 to 7.7 ng BK\/mm per mg protein. The density of BK2 binding sites also rose from 12 to 40 femtomoles\/mg protein with no difference in affinity. There was no change in specificity, which remained that expected of a BK2 receptor. The increase In the density of BK2 binding sites was associated with an augmented mRNA expression, whereas p-actmn mRNA used as a control remained unchanged. The ratio of BK2 mRNA to p-actin mRNA Indicated maximum steady expression after 8 wk of age. The data provide evidence that the renal kallikrein-kinin system devel-ops postnotally.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248400194,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The question of how neural systems encode memories in one-shot without immediately disrupting previously stored information has puzzled theoretical neuroscientists for years and it is the central topic of this thesis. Previous attempts on this topic, have proposed that synapses probabilistically update in response to plasticity inducing stimuli to effectively delay the degradation of old memories in the face of ongoing memory storage. Indeed, experiments have shown that synapses do not immediately respond to plasticity inducing stimuli, since these must be presented many times before synaptic plasticity is expressed. Such a delay could be due to the stochastic nature of synaptic plasticity or perhaps because induction signals are integrated before overt strength changes occur. The later approach has been previously applied to control fluctuations in neural development by low-pass filtering induction signals before plasticity is expressed. In this thesis we consider memory dynamics in a mathematical model with synapses that integrate plasticity induction signals to a threshold before expressing plasticity. We report novel recall dynamics and considerable improvements in memory lifetimes against a prominent model of synaptically stored memory. With integrating synapses the memory trace initially rises before reaching a maximum and then falls. The memory signal dissociates into separate oblivescence and reminiscence components, with reminiscence initially dominating recall. Furthermore, we find that integrating synapses possess natural timescales that can be used to consider the transition to late-phase plasticity under spaced repetition patterns known to lead to optimal storage conditions. We find that threshold crossing statistics differentiate between massed and spaced memory repetition patterns. However, isolated integrative synapses obtain an insufficient statistical sample to detect the stimulation pattern within a few memory repetitions. We extend the modelto consider the cooperation of well-known intracellular signalling pathways in detecting storage conditions by utilizing the profile of postsynaptic depolarization. We find that neuron wide signalling and local synaptic signals can be combined to detect optimal storage conditions that lead to stable forms of plasticity in a synapse specific manner. These models can be further extended to consider heterosynaptic and neuromodulatory interactions for late-phase plasticity.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":42690902,"openaccessinfo":{"externalids":{"MAG":"560372984","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study Federated Bandit, a decentralized Multi-Armed Bandit (MAB) problem with a set of N agents, who can only communicate their local data with neighbors described by a connected graph G. Each agent makes a sequence of decisions on selecting an arm from M candidates, yet they only have access to local and potentially biased feedback\/evaluation of the true reward for each action taken. Learning only locally will lead agents to sub-optimal actions while converging to a no-regret strategy requires a collection of distributed data. Motivated by the proposal of federated learning, we aim for a solution with which agents will never share their local observations with a central entity, and will be allowed to only share a private copy of his\/her own information with their neighbors. We first propose a decentralized bandit algorithm GossipUCB, which is a coupling of variants of both the classical gossiping algorithm and the celebrated Upper Confidence Bound (UCB) bandit algorithm. We show that GossipUCB successfully adapts local bandit learning into a global gossiping process for sharing information among connected agents, and achieves guaranteed regret at the order of O(max(poly(N,M) log T, poly(N,M) log\u03bb2-1 N)) for all N agents, where \u03bb2\u2208(0,1) is the second largest eigenvalue of the expected gossip matrix, which is a function of G. We then propose FedUCB, a differentially private version of GossipUCB, in which the agents preserve \u03b5-differential privacy of their local data while achieving O(max poly(N,M)\/\u03b5 log2.5 T, poly(N,M) (log\u03bb2-1 N + log T)) regret.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":235348816,"openaccessinfo":{"externalids":{"MAG":"3094364818","ACL":null,"DOI":"10.1145\/3543516.3453919","PubMedCentral":null,"ArXiv":"2010.12763"},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3543516.3453919","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Nitrification of ammonium nitrogen (NH4+-N)-bearing synthetic wastewater was performed in a batch-activated sludge reactor by varying the initial ammonium nitrogen concentration up to 400 mg\/L at a pH of 8.1 \u00b1 0.2 and temperature of 36 \u00b1 2 \u00b0C for developing the process kinetics using acclimatised biomass. Maximum ammonium nitrogen removal efficiency of 98.3% was achieved with initial ammonium nitrogen and mixed liquor suspended solids concentration of 235 mg\/L and 2,180 mg\/L, respectively, at 48 h batch period. Based on the experimental results, kinetic constants for ammonia nitrogen removal following Monod's approach were obtained as maximum substrate removal rate coefficient = 0.057 per day, yield coefficient = 0.336 mg volatile suspended solids\/mg ammonium nitrogen, half velocity constant = 12.95 mg NH4+-N\/L and endogenous decay constant = 0.02 per day. Nitrification is a consecutive reaction with ammonium oxidation as the first step followed by nitrite oxidation. The overall rate of nitrite and nitrate formation was observed to be 1.44 per day and 0.34 per day, respectively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212786008,"openaccessinfo":{"externalids":{"MAG":"3007891784","ACL":null,"DOI":"10.2166\/wst.2020.080","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iwaponline.com\/wst\/article-pdf\/81\/1\/62\/676845\/wst081010062.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The experimental arrangement used to examine light pulses of the driftless-gas-scintillation proportional counter are described and two applications using pulse-shape parameters are discussed. Since true X-rays should have a profile at least similar to a particular shape, events with a widely different profile can be rejected immediately. Events that have no software-discernable plateau are labeled spurious. This procedure typically rejects 60% of all laboratory background events. The problem of the dependency of the integrated light pulse (pulse height) on burst length is the second application considered for use with higher-energy X-rays. >","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":109222522,"openaccessinfo":{"externalids":{"MAG":"2012498794","ACL":null,"DOI":"10.1109\/23.3696","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nThe objectives of this study were to determine which serum thyroid hormone test best identifies iatrogenic hypothyroidism in cats that develop azotaemia after radioiodine treatment and to determine which thyroid test best differentiates these azotaemic, hypothyroid cats from azotaemic, radioiodine-treated euthyroid cats, as well as from azotaemic cats with chronic kidney disease and no history of thyroid disease.\n\n\nMATERIALS AND METHODS\nA total of 42 hyperthyroid cats that developed azotaemia (serum creatinine \u00ea220\u2009\u00b5mol\/L) after radioiodine treatment had serum concentrations of thyroxine and free thyroxine by dialysis and thyroid--stimulating hormone measured at 3, 6 and 12 months. Iatrogenic hypothyroidism was confirmed (n=28) or excluded (n=14) on the basis of thyroid scintigraphy. A total of 14 cats with chronic kidney disease and 166 clinically normal cats underwent similar serum thyroid testing and scintigraphy.\n\n\nRESULTS\nConcentrations of thyroxine and free thyroxine were lower and thyroid-stimulating hormone higher in hypothyroid cats than in all three groups of euthyroid cats (P<0\u00b70001). Of the hypothyroid cats, thyroxine and free thyroxine concentrations were low in 15 (53\u00b76%) and seven (25%), respectively. Low serum thyroxine and free thyroxine concentrations were also detected in seven (50%) and two (14\u00b73%) of the cats with chronic kidney disease. Thyroid-stimulating hormone concentrations were elevated in all hypothyroid cats but remained within the reference interval in all three groups of euthyroid cats. Serum thyroid--stimulating hormone had a higher test sensitivity and specificity than either thyroxine or free thyroxine concentration.\n\n\nCLINICAL SIGNIFICANCE\nThe finding of high serum thyroid-stimulating hormone concentrations best identifies feline iatrogenic hypothyroidism and differentiates it from non-thyroidal illness syndrome in cats that develop azotaemia after treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5721039,"openaccessinfo":{"externalids":{"MAG":"2725935907","ACL":null,"DOI":"10.1111\/jsap.12695","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, a novel method of automatic image annotation based on the Vector Quantization (VQ) compression domain is presented. The Co-occurrence statistical model was the inspiration behind developing this method, in which the combination of the global and regional features is used for the annotation process. The labeled images are compressed using the VQ compression method. Subsequently, the regional features are extracted from the images and are weighted. The Seed K-means (SK-means) semi-supervised clustering method is employed to increase the accuracy of clustering the weights obtained. Since the global and regional features emphasize different aspects of images and complement each other, the combinational approach of the global and regional features is adopted for the testing stage, and the unlabeled images are annotated. The results of the test on 5000 images from the Corel collection revealed that the proposed method is more efficient than the other methods in the uncompressed domain.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":14496315,"openaccessinfo":{"externalids":{"MAG":"1975167396","ACL":null,"DOI":"10.1109\/AISP.2012.6313730","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper explores the Greek management context from various perspectives such as the national culture distinctive characteristics (i.e., dominant societal values) and the findings of research conducted on the Greek management context since the early 1980s. The overall conclusion is that Greek management is influenced by both the European\/global business environment and the national\/local distinctive characteristics and societal values. Based on the existing literature, it was found that until the end of 2000s, Greek and Western management co-existed in a delicate balance. What remains to be seen are the devastating results of the prolonged economic crisis that has affected not only Greece, but all Southern European countries. The balance is now disturbed and we are only at the beginning of our understanding of this new reality, not only in management and the workplace but in also in our everyday lives.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":59158464,"openaccessinfo":{"externalids":{"MAG":"2023902774","ACL":null,"DOI":"10.1504\/EJCCM.2014.063403","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Multiple sclerosis is a chronic neurological disease with increasing incidence and prevalence worldwide being the main cause of non-traumatic disability in young adults. Both acute and chronic pain have been mentioned as the most common symptoms among those patients. Objective: This study was designed to evaluate the pain experience among patients with multiple sclerosis by describing its prevalence, characteristics, analgesic treatment and its efficacy, and also the impact of pain on quality of life. Methods: A cross-sectional observation survey was carried out on patients with multiple sclerosis followed in a tertiary hospital. Data were collected between December 2019 and March 2021 from a structured telephone inquiry, applying two questionnaires, the Brief Pain Inventory and the McGill Pain Questionnaire (MPQ), to evaluate the prevalence of pain and its impact on quality of life (QoL). Clinical records were also consulted to obtain data on disease duration, year of diagnosis, MS type, Expanded Disability Status Scale (EDSS) score. Results: Our sample included 305 patients in a universe of 1500, mainly women, with mean age of 44.27 years, and most of them presented with an outbreak-remission subtype of disease. One hundred twenty-four patients experienced pain which corresponds to 41% of the patients. Considering the patients who experienced pain, 67.7% were under treatment and of these, 64.3% with only one painkiller. Pain significantly interfered with general activity, mood, and regular work. Conclusion: Pain was an important symptom in this group of patients with MS and significantly interfered with mood, general activity, and regular work. The maximum intensity of pain felt by patients was significant and only 67.7% of patients were under analgesic treatment with mean pain relief of 54. NSAIDs were the most used drugs followed by gabapentinoids and acetaminophen for the management of pain. Medical community must continue to study this population in order to improve the approach to pain in these patients and improve quality of life.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":246847528,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.7759\/cureus.22213","PubMedCentral":"8925990","ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.7759\/cureus.22213","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In order to solve the real-time parameter adjustment problem of the speed sensorless vector control system for the induction motor, the paper presents a fuzzy self-adaptive method with intelligent gain adjustment. By the means of the sensorless vector control for induction motor, adapt Model reference adaptive system (MRAS) to achieve the rotor position estimation to improve the speed and estimated accuracy, and then design the out-loop controller to achieve high response of speed control. So applying the method of the fuzzy self-adaptive parameter adjustment, track and correct controller parameters in time to achieve high dynamic response. The simulation results confirm the validity and effectiveness of the proposed control strategy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":70101250,"openaccessinfo":{"externalids":{"MAG":"2903266282","ACL":null,"DOI":"10.9734\/bjast\/2016\/19893","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Strawberry is one of the most commonly cultivated and consumed plant, due to its organoleptic properties and nutritional values, exerting multiple beneficial health effects. In this study, two distinct strawberry callus lines obtained in different lighting conditions were characterized. The biotechnological potential of these cultures can be demonstrated by biomass and secondary metabolites accumulation. For this reason, growth rate, cellular morphology and viability were assessed. For metabolic potential evaluation, biochemical analyses of total phenolic and flavonoid content, anthocyanin pigments concentrations and antioxidant capacity were performed. The red callus line displayed higher growth rate, total phenolic content and antioxidant activity than the white line. Flavonoids and anthocyanins were present only in the red line. The biomass and these metabolites accumulation varied between subcultures, but were maintained at a high rate, being superior to values reported in planta. Our results show that both callus cultures lines were highly proliferative and the red one being a source of valuable bioactive secondary metabolites, with high antioxidant activity.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":255740769,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17930\/agl2022213","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.17930\/agl2022213","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Cycling of NROM-type memory cells leads to a dipolar distribution inside the nitride layer. This effect is due to a mismatch between hole and electron injected profiles resulting from conventional NROM operation. An extraction technique based on CP measurements allows the detailed observation of the mismatch. The proposed model explains the relation between the charge distributions and the cycling behavior which is experimentally confirmed by changing the programming and erasing conditions","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":36860437,"openaccessinfo":{"externalids":{"MAG":"2157202522","ACL":null,"DOI":"10.1109\/.2006.1629497","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effect of track-edge amplitude asymmetry on position-error signal, PES, of spin-valve GMR heads was investigated. Cross-track profiles of both amplitude and amplitude asymmetry are showed along with the PES line of the head. The results indicated that amplitude-asymmetry effect from servo burst is finite but not significant enough to alter PES sensitivity, or the slope of PES line. However, it is shown experimentally that the PES linearity is functionally correlated with asymmetry of the servo bursts, which substantiates the track-edge effect of spin-valve heads.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":123595329,"openaccessinfo":{"externalids":{"MAG":"2107770951","ACL":null,"DOI":"10.1109\/20.908525","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Temperature rise distribution at the drawlead cables in the condenser bushings was studied with a thermal model and actual thermal tests. Temperature rise of the hottest spot at the cables from the model is consistent with that from the tests within a 10% deviation. Factors that influence working current and overload capacity of the cable were studied. Current-carrying capacities of the drawlead cables with index 105 insulation are presented based on thermal basis of rating.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110668413,"openaccessinfo":{"externalids":{"MAG":"2098836943","ACL":null,"DOI":"10.1109\/61.871354","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper reports, for solutions of 0.001 M uranyl sulfate and 0.005 M oxalic acid, a 10-degree temperature coefficient, up to 85\u00b0C (using a base temperature of 25\u00b0) of 1.02\u00b10.01 at 254 m\/x. Measurements in more dilute solutions show a decrease to approximately unity at 0.00025 M uranyl sulfate\u20140.00125 M oxalic acid, with indication that it may become less than unity on further dilution. Quantum yields measured (using uranyl oxalate as standard), by students under a National Science Foundation \"pilot\" undergraduate participation project, on actinometers at 254 rn.fi, were for (1) malachite green leucocyanide, 0.9; (2) monochloroacetic acid, 0.3; and (3) potassium ferrioxalate, 1.24 moles per einstein.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":93176525,"openaccessinfo":{"externalids":{"MAG":"1495272593","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper draws on a series of texts written by jurists of the Maliki School of Law between the 8th and the 15th century. The variety of these sources and their examination in chronological order makes it possible to sketch different stages of elaboration and observing the relationship between doctrinal development and legal practice within the Maliki School of that period. My conclusion is that Maliki doctrine on rape was far from being monolithic, and that it changed over time as a result of a series of efforts to accommodate social demands and on the grounds of rationality, equity and justice.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144120489,"openaccessinfo":{"externalids":{"MAG":"2018714490","ACL":null,"DOI":"10.1163\/156920807782912481","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The role of temperature on deposition in gas turbine internal cooling geometries is investigated. Single impingement cones are developed by an oversized (6 mm) impinging jet over a range of temperatures and flow velocities using 0\u20135 \u03bcm ARD. Cone size was found to increase with increasing temperature and decrease with increasing velocity. Capture efficiency and cone angle effects are presented, and packing factor data is used as a metric to determine if the contact area (Acont) for adhesion explains the trends seen with temperature. It is systematically demonstrated that the surface free energy (\u03b3) is likely a first order function of temperature in internal deposition for the range of temperatures investigated. Candidate physical mechanisms that may cause increased adhesive force at elevated temperatures are identified. Temperature dependent adhesion is added to the OSU Deposition Model which is then used with a simplified morphing approach to match temperature induced blockage patterns in a vane leading edge cooling experiment. This process is improved upon using a full mesh morphing routine and matching two of the experimental deposition cones at varied flow temperatures. The added fidelity that mesh morphing affords is demonstrated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":242095025,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/gt2018-76251","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The interplay of personality and social relationships is as fascinating as it is complex and it pertains to a wide array of largely separate research domains. Here, we present an integrative and unified framework for analysing the complex dynamics of personality and social relationships (PERSOC). Basic principles and general processes on the individual and dyadic level are outlined to show how personality and social relationships influence each other and develop over time. PERSOC stresses the importance of social behaviours and interpersonal perceptions as mediating processes organized in social interaction units. The framework can be applied to diverse social relationships such as first encounters, short\u2013term acquaintances, friendships, relationships between working group members, educational or therapeutic settings, romantic relationships and family relationships. It has important consequences for how we conceptualize, understand, and investigate personality and social relationships. Copyright \u00a9 2011 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":14164590,"openaccessinfo":{"externalids":{"MAG":"2097548880","ACL":null,"DOI":"10.1002\/per.811","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/osf.io\/nczzp\/download","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Treated wastewater in micro-irrigation is a promising approach that could be used to decrease the pressure on good quality water resources. However, the clogging of such systems due to biofilm development and chemical precipitation constitute a constraint with the use of treated wastewater (TWW) and lead to lower irrigation system performance. The objective of this work is to study the development of biofilm and composition of fouling due to TWW under shear stresses of 0.7, 2.2 and 4.4\u2005Pa detected along micro-irrigation systems. For this purpose, a Taylor-Couette reactor (TCR) was specifically calibrated for the cultivation of biofilm. The analysis of fouling composition samples (organic and inorganic) shows that biofilm tends to develop under the highest shear stress value (4.4\u2005Pa). Precipitation of calcium carbonate in the form of calcite was observed in conjunction with biofilm growth using X-ray diffractometry (XRD) and thermogravimetric analysis (TGA). These results can be used to ascertain the origins of chemical and biological clogging of drippers and fouling of pipes related to reclaimed water- irrigation. GRAPHICAL ABSTRACT","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":169040376,"openaccessinfo":{"externalids":{"MAG":"2946891366","ACL":null,"DOI":"10.1080\/09593330.2019.1625956","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.archives-ouvertes.fr\/hal-02145454\/file\/Article%20Rizk%20et%20al%202019%20final_2.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Some psychological mechanisms, regarding the new techniques of ART are reported in this work. A short overview of Freudian theory of psychosexual development of the child is given. The narcissistic wound induced by the diagnosis of sterility is quite important but quite different for men and women. It seems that oocyte donation may \"cure\" fantasmatically some female sterilities, given that this technique allows some women to get pregnant and to deliver a child, which was until then out of their biological \"fate\". Whether the anonymity of gamete donation is adapted to the psychic structure of recipients, donors, and medical teams is a question that should be considered. Very few works have been reported about the fantasies of the medical teams on this topic. The importance of infantile sexual theries is stressed again.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40528178,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Context: Nonpharmacological interventions (NPIs) have been advocated for knee osteoarthritis (KOA). There are many gaps in the evidence to their efficacy in India. Aims: The study aims to compare the impact of two packages of NPIs on various outcome variables of KOA patients. Settings and Design: This was a randomized controlled trial in a tertiary care hospital. Subjects and Methods: A study population (n = 123) of KOA patients aged 40\u201365 years. Stratified block randomization was done for mild or moderate KOA into two groups. Group \"A\" patients received a package of NPIs including a set of supervised exercise sessions, kinesthesia, balance, and agility (KBA), meditation, weight reduction advice, and weekly telephonic reminders. Group \"B\" patients received the same package except for KBA & meditation. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), visual analog scale (VAS) and performance-based measures were measured. Analysis: t-test and repeat measures ANOVA were undertaken. Results: A significant intragroup reduction in WOMAC score was seen from baseline in Group A (P = 0.00, mean difference: \u22129.7) as well as in Group B (P = 0.00, \u221212.9). There was also significant reduction inVAS scores at the end of intervention in Group A and Group B as compared from baseline (\u22123.62, \u22123.8, P = 0.00). No intergroup difference was observed in either of the scores. VAS score reduction to 0 at different stages of intervention was noticed in 46% (n = 57) cases. There was a significant intergroup difference for 50-Foot Walk Test (P = 0.055, F = 3.28) at 12 months. Conclusion: Both packages of NPIs were effective in providing relief in symptoms. No specific benefit of KBA or meditation was seen except for 50FWT.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":53212601,"openaccessinfo":{"externalids":{"MAG":"2896907539","ACL":null,"DOI":"10.4103\/IJPC.IJPC_14_18","PubMedCentral":"6199827","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There is widespread agreement on the many benefits citizens gain from recreational use of local green spaces such as urban woodlands, and the importance of involving users in the development of their everyday landscapes. Despite this, the impact of user participation on the quality of public green spaces has not been thoroughly studied. In this PhD thesis, resident participation in public urban woodland management including drivers for participating, impact on the quality of the woodland, and ways in which local authorities can facilitate it in a long-term perspective was explored. The topic was studied through a literature review and a seven-year longitudinal, mixed-method case study of the residential area Sletten in Holstebro, Denmark. The literature review identified a general lack of empirical support for the many assumed positive outcomes of user participation in the different phases of green space development. A particularly large disparity was found between assumed and empirically substantiated knowledge on how participation may directly benefit physical urban green spaces. \n \nThe purpose of the case study was to investigate the topic with focus on resident participation in management of public urban woodlands. In Sletten, residents participate in the maintenance and management of the public woodland edge zone bordering their private gardens, called the co-management zone. It was found that clear guidelines and continuous local authority\u2013resident communication, including municipal guidance, inspiration and control, were crucial for a functional co-management zone. The study of residents' drivers of participation pointed at combinations of both personal and environmental drivers, the relative importance of which changed over time from gardening interest, stand height and residents inspiring their neighbours in 2010, to forest edge type and length of residence in 2015. Local authorities aiming to facilitate co-management should be aware of this temporal dimension and encourage participation by identifying people interested in gardening who inspire others, combined with strategic woodland vegetation design and management increasing visual and physical accessibility. In Sletten, it was found that social, experiential, functional, and ecological dimensions were all included in residents' perceptions of 'urban woodland quality'. Maintenance, accessibility, nature and facilities are aspects that occur repeatedly in quality assessment schemes for other types of urban green space. These were also central to urban woodland quality, apart from facilities. In addition, the study revealed the importance of structural and species diversity between and within woodland stands \u2013 a quality aspect that distinguishes woodland from other types of urban green space. It was also found that participation had additional benefits for participants. This research has contributed new insights, useful to green space managers in their work when involving users in management, and has provided new approaches to the scientific discussion on green space quality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":134200473,"openaccessinfo":{"externalids":{"MAG":"2911561695","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Food defect detection is crucial for the automation of food production and processing. Potato surface defect detection remains challenging due to the irregular shape of potato individuals and various types of defects. This paper employs deep convolutional neural network (DCNN) models for potato surface defect detection. In particular, we applied transfer learning by fine-tuning a base model through three DCNN models\u2014SSD Inception V2, RFCN ResNet101, and Faster RCNN ResNet101\u2014on a self-developed dataset, and achieved an accuracy of 92.5%, 95.6%, and 98.7%, respectively. RFCN ResNet101 presented the best overall performance in detection speed and accuracy. It was selected as the final model for out-of-sample testing, further demonstrating the model's ability to generalize.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":240522687,"openaccessinfo":{"externalids":{"MAG":"3199123638","ACL":null,"DOI":"10.3390\/agriculture11090863","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2077-0472\/11\/9\/863\/pdf?version=1631258509","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nPhenylketonuria is an inherited disease treated with dietary restriction of the amino acid phenylalanine. The diet is initiated in the neonatal period to prevent mental handicap; however, it is restrictive and can be difficult to follow. Whether the diet can be relaxed or discontinued during adolescence or should be continued for life remains a controversial issue, which we aim to address in this review.\n\n\nOBJECTIVES\nTo assess the effects of a low-phenylalanine diet commenced early in life for people with phenylketonuria. To assess the possible effects of relaxation or termination of the diet on intelligence, neuropsychological outcomes and mortality, growth, nutritional status, eating behaviour and quality of life.\n\n\nSEARCH STRATEGY\nWe searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings.Most recent search of the Inborn Errors of Metabolism Trials Register: 05 March 2009.\n\n\nSELECTION CRITERIA\nAll randomised or quasi-randomised controlled trials comparing a low-phenylalanine diet to relaxation or termination of dietary restrictions in people with phenylketonuria.\n\n\nDATA COLLECTION AND ANALYSIS\nTwo authors independently assessed study eligibility and methodological quality, and subsequently extracted the data.\n\n\nMAIN RESULTS\nWe included four studies in this review (251 participants), and found few significant differences between treatment and comparison groups for the outcomes of interest. Blood phenylalanine levels were significantly lower in participants with phenylketonuria following a low-phenylalanine diet compared to those on a less restricted diet, mean difference (MD) at three months -698.67 (95% confidence interval (CI) -869.44 to -527.89). Intelligence quotient was significantly higher in participants who continued the diet than in those who stopped the diet, MD after 12 months 5.00 (95% CI 0.40 to 9.60). However, these results came from a single study.\n\n\nAUTHORS' CONCLUSIONS\nThe results of non-randomised studies have concluded that a low-phenylalanine diet is effective in reducing blood phenylalanine levels and improving intelligence quotient and neuropsychological outcomes. We were unable to find any randomised controlled studies that have assessed the effect of a low-phenylalanine diet versus no diet from diagnosis. In view of evidence from non-randomised studies, such a study would be unethical and it is recommended that low-phenylalanine diet should be commenced at the time of diagnosis. There is uncertainty about the precise level of phenylalanine restriction and when, if ever, the diet should be relaxed. This should be addressed by randomised controlled studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205163223,"openaccessinfo":{"externalids":{"MAG":"1538259514","ACL":null,"DOI":"10.1002\/14651858.CD001304.pub2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As multiple types of traffic converge onto one network, frequently wireless, enterprises face a tradeoff between effectiveness and security. Some types of traffic, such as voice-over-IP (VoIP), require certain quality of service (QoS) guarantees to be effective. The end client platform is in the best position to know which packets deserve this special handling. In many environments (such as universities), end users relish having control over their own machines. However, if end users administer their own machines, nothing stops dishonest ones from marking undeserving traffic for high QoS. How can an enterprise ensure that only appropriate traffic receives high QoS, while also allowing end users to retain control over their own machines? In this paper, we present the design and prototype of a solution, using SELinux, TCPA\/TCG hardware, Diffserv, 802.1x, and EAP-TLS.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":855874,"openaccessinfo":{"externalids":{"MAG":"2539824564","ACL":null,"DOI":"10.1109\/SECCMW.2005.1588319","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This thesis consists of two distinct parts that have been thoroughly investigated as to the components that make up the relevant legal regime and the importance of their implementation. The first part discusses the institution of the Exclusive Economic Zone and all data associated with it. The second part of the paper is devoted to a detailed description of the multifaceted and complex framework of fisheries. These two institutions of international law of the sea are thus the main subject of this essay. When taking into account coastal states they can be applied in a complementary and practical way. They can also be used when issues that are economically vital, such as claiming and exercising sovereign rights, are raised. \nFurthermore this work aims to allow the formation of a crystallized image of the institutional framework of the EEZ and the Law of fishing, which will in turn contribute to highlight these as cornerstones in the modern, ever evolving international law.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":158363729,"openaccessinfo":{"externalids":{"MAG":"2791950706","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background The study is designed to explore the chest CT features of different clinical types of coronavirus disease 2019 (COVID-19) pneumonia based on a Chinese multicenter dataset using an artificial intelligence (AI) system. Methods A total of 164 patients confirmed COVID-19 were retrospectively enrolled from 6 hospitals. All patients were divided into the mild type (136 cases) and the severe type (28 cases) according to their clinical manifestations. The total CT severity score and quantitative CT features were calculated by AI pneumonia detection and evaluation system with correction by radiologists. The clinical and CT imaging features of different types were analyzed. Results It was observed that patients in the severe type group were older than the mild type group. Round lesions, Fan-shaped lesions, crazy-paving pattern, fibrosis, \"white lung\", pleural thickening, pleural indentation, mediastinal lymphadenectasis were more common in the CT images of severe patients than in the mild ones. A higher total lung severity score and scores of each lobe were observed in the severe group, with higher scores in bilateral lower lobes of both groups. Further analysis showed that the volume and number of pneumonia lesions and consolidation lesions in overall lung were higher in the severe group, and showed a wider distribution in the lower lobes of bilateral lung in both groups. Conclusions Chest CT of patients with severe COVID-19 pneumonia showed more consolidative and progressive lesions. With the assistance of AI, CT could evaluate the clinical severity of COVID-19 pneumonia more precisely and help the early diagnosis and surveillance of the patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225175891,"openaccessinfo":{"externalids":{"MAG":"3092864910","ACL":null,"DOI":"10.21037\/JTD-20-1584","PubMedCentral":"7656439","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Palladium, iridium, and rhodium complexes of 2-methyleneimidazolines have been synthesized by selective phosphine-assisted activation of the 2-methyl C-H bonds in 2-methylimidazolium compounds. Metallacycles of various sizes were obtained in the reaction of phosphine-tethered 2-methylimidazolium compounds and [{M(cod)X}(2)] (M = Rh or Ir; cod = 1,5-cyclooctadiene; X = alkoxyl or Cl). Representative complexes were characterized by X-ray crystallography. The selectivity for aliphatic C(sp(3))H versus aromatic C(sp(2))H activation could be adjusted by means of the steric bulk of the OR ligand, whereby a bulky OR group favors activation of the 2-methyl C(sp(3))-H bond. Experimental results confirmed that a methyl C-H activation product (a seven-membered iridacycle) is the kinetic product, while the aryl C-H activation product (a six-membered iridacycle) is the thermodynamic product.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205584354,"openaccessinfo":{"externalids":{"MAG":"2137611453","ACL":null,"DOI":"10.1002\/chem.200802569","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"At present, the effective ways to improve the cleanliness of S50C die steel are Ca or Mg-Al treatment processes. In order to explore the effect difference of two kinds of modification process of S50C killed steel, evaluate the industrial application prospect of the two processes, and clarify the modification mechanism. In this paper, the advantages of Mg-Al modification are demonstrated from the aspects of theoretical basis and actual sample modification effect. The thermodynamics and kinetics of inclusion precipitation, composition, morphology, and distribution are analyzed. The results show that: the precipitation temperature of MnS in S50C die steel is 1686\u2009K, the corresponding solid-phase rate is 0.98. In Mg-Al modification, when the Al content is 332\u2009ppm, the Mg content should be controlled below 14.1\u2009ppm. When the Al content is higher than 0.02%, the Ca content should be controlled below 28.7\u2009ppm. Kinetic calculations show that the equilibrium shape size of MnS is in the range of 0.3\u20111.4\u2009\u00b5m. Both modifications increase the nucleation rate of inclusions and control the shape and size of inclusions by pre-precipitation. Ca treatment is preventing the formation of large inclusions by forming calcium aluminate. Mg can provide more uniform nucleation sites and form smaller inclusions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":240573373,"openaccessinfo":{"externalids":{"MAG":"3199688273","ACL":null,"DOI":"10.1051\/metal\/2021049","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) bind to and activate the same PTH\/PTHrP receptor. Deletion of either the PTHrP gene or the PTH\/PTHrP receptor gene leads to acceleration of differentiation of growth plate chondrocytes. To explore further the functional relationships of PTHrP and the PTH\/PTHrP receptor, bones of knockout mice were analyzed early in development, and the phenotypes of double-knockout mice were characterized. One early phenotype is shared by both knockouts. Normally, the first chondrocytes to become hypertrophic are located in the centers of long bones; this polarity is greatly diminished in both these knockouts. The PTH\/PTHrP receptor-deficient (PTH\/PTHrP-R(-\/-)) mice exhibited 2 unique phenotypes not shared by the PTHrP(-\/-) mice. During intramembranous bone formation in the shafts of long bones, only the PTH\/PTHrP-R(-\/-) bones exhibit a striking increase in osteoblast number and matrix accumulation. Furthermore, the PTH\/PTHrP-R(-\/-) mice showed a dramatic decrease in trabecular bone formation in the primary spongiosa and a delay in vascular invasion of the early cartilage model. In the double-homozygous knockout mice, the delay in vascular invasion did not occur. Thus, PTHrP must slow vascular invasion by a mechanism independent of the PTH\/PTHrP receptor.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11045580,"openaccessinfo":{"externalids":{"MAG":"2100503761","ACL":null,"DOI":"10.1172\/JCI6629","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A standard way of tolerancing optical elements or systems is to perform a Monte Carlo based analysis within a common optical design software package. Although, different weightings and distributions are assumed they are all counting on statistics, which usually means several hundreds or thousands of systems for reliable results. Thus, employing these methods for small batch sizes is unreliable, especially when aspheric surfaces are involved. The huge database of asphericon was used to investigate the correlation between the given tolerance values and measured data sets. The resulting probability distributions of these measured data were analyzed aiming for a robust optical tolerancing process.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":67039099,"openaccessinfo":{"externalids":{"MAG":"2765959226","ACL":null,"DOI":"10.1117\/12.2279775","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We analyzed the fecal microbiome by deep sequencing of the 16S ribosomal genes and the metabolomic profiles of 43 intestinal transplant recipients to identify biomarkers of graft function. Stool samples were collected from 23 patients with stable graft function five years or longer after transplant, 15 stable recipients one-year post-transplant and four recipients with refractory rejection and graft loss within one-year post-transplant. Lactobacillus and Streptococcus species were predominant in patients with stable graft function both in the short and long term, with a microbiome profile consistent with the general population. Conversely, Enterococcus species were predominant in patients with refractory rejection as compared to the general population, indicating profound dysbiosis in the context of graft dysfunction. Metabolomic analysis demonstrated significant differences between the three groups, with several metabolites in rejecting recipients clustering as a distinct set. Our study suggests that the bacterial microbiome profile of stable intestinal transplants is similar to the general population, supporting further application of this non-invasive approach to identify biomarkers of intestinal graft function.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":251872843,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/biomedicines10092079","PubMedCentral":"9495872","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2227-9059\/10\/9\/2079\/pdf?version=1661837948","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Evapotranspiration (ET) is an important part of both water balance and energy balance. Accordingly, the estimation of ET plays a key role in research related to regional water resources and energy balance. Using the largest inland freshwater lake in China\u2014Bosten Lake Basin\u2014as a target area, this study employs the SEBAL model combined with actual surface ET from the 2013 MODIS ET data to estimate ET in the Bosten Lake Basin from a time and space perspective. The findings include the following: (1) Evapotranspiration in the Bosten Lake Basin shows a unimodal distribution in terms of time distribution, with the highest ET occurring in July and August. In terms of spatial distribution, the overall trend is more apparent in the northwest portion of the basin than the southeast portion, as there are more mountains in the northwest as well as fewer desert areas. (2) Grassland and unused land were the main types of land cover, and ET exhibited a clear relationship to vegetation coverage and water supply. The distribution of land use types from northwest to southeast ET show a significant downward trend. (3) During the growing season, the average daily ET level of land use\/cover type was the greatest over water bodies (5.61 mm\/d), followed by grassland (4.6 mm\/d) and snow\/ice (4.29 mm\/d), with unused land giving the smallest amounts of ET.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1}},"corpusid":225332111,"openaccessinfo":{"externalids":{"MAG":"3083701472","ACL":null,"DOI":"10.3390\/su12187293","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2071-1050\/12\/18\/7293\/pdf?version=1599305305","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this paper, the authors discuss various properties of solutions for the generalized \u03b1\u2212difference equation \u2206\u03b1(l)u(k \u2212 2l) = \u03b1 p(k)u(k), k \u2208 [2l,\u221e), (1) where the functions p is positive on [2l,\u221e), \u03b1 > 1 and l is a positive real. AMS Subject Classification: 39A, 12","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":122214177,"openaccessinfo":{"externalids":{"MAG":"2029069808","ACL":null,"DOI":"10.12732\/IJPAM.V96I1.9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article presents what Americans think about the policies subsumed under the label of the \"War on Drugs.\" It is based on an analysis of 47 national surveys conducted between 1978 and 1997. The major results are that most Americans rely on the mass media for information about the scope of the drug abuse problem; Americans do not think that the Wars on Drugs have succeeded, but they do not want to quit on these efforts; weak support exists for increasing funding for drug treatment; support for preventive education has increased during the 1990s; criminal justice responses remain very popular; for many, illicit drug use is a moral rather than a public health issue; the public supports allowing physicians to prescribe marijuana for severe illness, but opposes the general legalization of marijuana and other illicit drugs; and needle exchange programs are supported by a bare majority, but only when they are told that the American Medical Association supports these programs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38480960,"openaccessinfo":{"externalids":{"MAG":"2027117841","ACL":null,"DOI":"10.1001\/JAMA.279.11.827","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Apolipoprotein E (apoE) has important functions in systemic and local lipid transport, but also has other functions. The gene (APOE) shows a common polymorphism with three alleles \u2013 APOE*2, APOE*3, and APOE*4. Their frequencies vary substantially around the world, but APOE*3 is the most common almost everywhere and is often considered to be the ancestral or \"wild-type\" allele for that reason. However, there are several arguments for APOE*4 being the ancestral allele. But then, why has APOE*3 become so frequent? And why has APOE*4 not become extinct? The proportion of APOE*4 carriers increases from only 10\u201315% in southern Europe to 40\u201350% in the north. The gradient may be a trace of the demic expansion of agriculture that began about 10,000 years ago, but it may also reflect the possibility that APOE*4 carriers are less likely to develop vitamin D deficiency. The common APOE polymorphism is associated with varying risk of cardiovascular disease and Alzheimer's disease, but other interesting aspects may emerge in the future.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":1822252,"openaccessinfo":{"externalids":{"MAG":"2005246739","ACL":null,"DOI":"10.1515\/CCLM.2003.094","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The stage when romantic relationships come to an end ('breakup') has been linked to a range of adverse psychological and psychosocial impacts in adolescents. Breakups have been linked to an increased risk of depression, self-harm, suicidal thoughts and\/or suicide attempts as well as increased psychological distress, risk- taking behaviour and poor functioning in future relationships. Concerns regarding romantic relationships, particularly breakups, consistently feature in the top five reasons why 50,000+ young people (5-25 years) contact Kids Helpline for counselling support each year. Despite the salience and severity of breakups among young people, few publicly available web or mobile-based programs for relationship breakups in young people are available. For this project the research team conducted a series of five co-design workshops with young people and collaborated with Kids Helpline to develop an app aimed at helping young people recover after a distressing breakup. The 'Breakup Shakeup' app utilises a behavioural activation approach to help teach young people obtain social support and learn new coping strategies to help them recover from a breakup. Brake Up Shake Up was conceptualised, designed and developed in collaboration with yourtown, Kids Helpline and the Young and Well CRC. An interdisciplinary team involving psychology, relationship design, gamification and marketing, experts from QUT were involved in the project.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":224225388,"openaccessinfo":{"externalids":{"MAG":"3030175918","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary form only given. The efficient development of composite applications is discussed with the focus being on the use of software components to package the user code that is used to build the composite applications. Because of the complex nature of scientific applications, using software components in a plug-and-play style is not so simple. The design of the software components (or user tasks) and the frameworks used to integrate them into a composite application need to support a great deal of flexibility. This is needed to allow efficient experimentation in the development of the application. Additionally, frameworks need to assist the application developer beyond just ensuring interface compatibility. Matching the internal behavior of two user tasks that are coupled in a composite application is equally important. While a completely automatic behavioral analysis may never be a reality, frameworks can include sub-systems that provide the user with insight as to the compatibility of the integration of a task into a composite application. The goal of the research program is to address the above issues by applying several relatively new techniques to explore the design of components, frameworks, and the associated programming styles. Metadata is being used extensively to describe various elements of an application and a framework and software tools are being developed that use this metadata to augment the execution of the user tasks. Aspect-oriented programming concepts are being used to support better modularity and portability in the design of components and composite applications. Behavioral analysis techniques are being used to further enhance portability by including knowledge about the use of an task in its metadata.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-20":1,"2013-48":1}},"corpusid":2883639,"openaccessinfo":{"externalids":{"MAG":"2132062258","ACL":null,"DOI":"10.1109\/IPDPS.2004.1303220","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose. Tissue samples from patients with suspicion of deep or subcutaneous fungal infections were analysed at the Portuguese Reference Mycology Laboratory according to a proposed diagnostic approach, which aims to constitute a rapid and accurate diagnosis for these fungal infections. Methodology. Forty\u2010six tissue biopsy samples were analysed over a period of 26 months, using a diagnostic approach that includes culture, panfungal PCR and Aspergillus\u2010directed PCR. Results\/Key findings. Overall, 23 samples were reported as negative while the remaining 23 were reported as positive for fungi (PCR, culture and\/or histology). PCR showed an estimated detection limit of 12 pg DNA &mgr;l\u20101. From the 46 samples, 30 were negative for fungal DNA while 16 gave positive results. From these, 12 cases were detected by panfungal PCR and six cases by PCR directed toward Aspergillus. In 61 % of the cases, there was concordance between molecular and cultural methods. Aetiological agents identified were Candida albicans, C. glabrata, C. tropicalis, Trichosporon montevideense, Alternaria spp., Exophiala sp., Trichoderma sp., Histoplasma spp., Aspergillus fumigatus, Trichophyton rubrum and Paracoccidioides brasiliensis. Conclusion. Our results showed that the proposed polyphasic approach appears to be a useful strategy in the detection of fungi from tissue samples, allowing a better prognosis. In further studies, the inclusion of a higher number of samples and the implementation of more genus\u2010specific PCRs will certainly contribute to an increase in the specificity and sensitivity of this method.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":53738400,"openaccessinfo":{"externalids":{"MAG":"2902866337","ACL":null,"DOI":"10.1099\/jmm.0.000883","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1099\/jmm.0.000883","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The suggestion by Robert Cantor, that drug-induced pressure changes in lipid bilayers can change the conformational equilibrium between open and closed states of membrane proteins and thereby cause anesthesia, attracted much attention lately. Here, we studied the effect of both large external pressure and of 1-alkanols of different chain lengths--some of them anesthetics, others not--on the lateral pressure profiles across dimyristoylphosphatidylcholine (DMPC) bilayers by molecular dynamics simulations. For a pure DMPC bilayer, high pressure both reduced and broadened the tension at the interface hydrophobic\/hydrophilic and diminished the repulsion between the phospholipid headgroups. Whereas the effect of ethanol on the lateral pressure profile was similar to the effect of a large external pressure on a DMPC bilayer, long-chain 1-alkanols significantly amplified local maxima and minima in the lateral pressure profile. For most 1-alkanols, external pressure had moderate effects and did not reverse the changes 1-alkanols exerted on the pressure profile. Nevertheless, assuming the bent helix model as a simple geometric model for the transmembrane region of a membrane protein, protein conformational equilibria were shifted in opposite directions by addition of 1-alkanols and additional application of external pressure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46663317,"openaccessinfo":{"externalids":{"MAG":"2168307746","ACL":null,"DOI":"10.1529\/biophysj.108.142125","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific-oa","url":"http:\/\/www.cell.com\/article\/S0006349508819935\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The growing demand for improvements in in vitro drug screening, disease modelling, and regenerative tissue therapies poses an urgent clinical need for the continued development of innovative tissue engineering strategies. Several promising biofabrication and aggregation solutions have been developed to overcome these challenges, such as three-dimensional (3D) bioprinting and chip-based physiological models. However, replicating the structural and cytoarchitectural complexities of native tissue types to achieve biomimicry of epithelial, nervous, muscular, and connective tissues remains a significant area of investigation. Innovative research efforts focused on the thread-like morphologies of bodily tissues have been developed to overcome these challenges. This review features the recent and current work done in fiber fabrication methods and the associated textile assembly techniques utilized to create fiber-based microphysiological systems, specifically for applications in disease modelling and high throughput drug testing. The advantages and disadvantages of these different fiber fabrication and assembly approaches are compared. Finally, the applications of these textile-based biofabrication approaches in epithelial, nervous, connective, and muscle tissue engineering are reviewed.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":203705025,"openaccessinfo":{"externalids":{"MAG":"2973998710","ACL":null,"DOI":"10.21037\/mps.2019.08.01","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.21037\/mps.2019.08.01","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The temporal evolution of the effective climate sensitivity is shown to be influenced by the changing pattern of sea surface temperature (SST) and ocean heat uptake (OHU), which in turn have been attributed to ocean circulation changes. A set of novel experiments are performed to isolate the active role of the ocean by comparing a fully coupled CO2 quadrupling community Earth System Model (CESM) simulation against a partially coupled one, where the effect of the ocean circulation change and its impact on surface fluxes are disabled. The active OHU is responsible for the reduced effective climate sensitivity and weaker surface warming response in the fully coupled simulation. The passive OHU excites qualitatively similar feedbacks to CO2 quadrupling in a slab ocean model configuration due to the similar SST spatial pattern response in both experiments. Additionally, the nonunitary forcing efficacy of the active OHU (1.7) explains the very different net feedback parameters in the fully and partially coupled responses.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":133628703,"openaccessinfo":{"externalids":{"MAG":"2789246355","ACL":null,"DOI":"10.1002\/2017GL075633","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Prepulse inhibition (PPI) of the startle blink reflex in humans can be modulated by selective attention to the prepulse. The present experiment used a task that isolated the short-term consolidation of memory to determine whether this process modulates PPI. Participants were briefly presented with a display of one or three letters followed by a pattern mask and asked to make a delayed report of the letter(s) shown. Memory recall was better in the 1-letter condition than in the 3-letter condition. Prepulse inhibition was greater in the 3-letter condition than in the 1-letter condition at lead intervals of 120 and 240 ms following the onset of the letter display. Blink modulation did not differ between the letter conditions at lead intervals of 120, 240, 360, and 2600 ms following the mask, ruling out other explanations (e.g., rehearsal) for the earlier difference in PPI. The results suggest that the short-term consolidation of memory, and possibly any cognitive process that requires access to a theoretical limited capacity central processing mechanism, modulated PPI.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":141976462,"openaccessinfo":{"externalids":{"MAG":"1006792946","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A mononuclear high-valent trans-dioxoruthenium(VI) complex, trans-[Ru(VI)(TMC)(O)2](2+) (TMC = 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane), was synthesized and characterized by various spectroscopic techniques and X-ray crystallography. The reactivity of the trans-[Ru(VI)(TMC)(O)2](2+) complex was investigated in hydride transfer and hydrogen atom transfer reactions. The mechanism of hydride transfer from dihydronicotinamide adenine dinucleotide (NADH) analogues to trans-[Ru(VI)(TMC)(O)2](2+), which proceeds via a proton-coupled electron transfer (PCET), followed by a rapid electron transfer (ET), has been proposed by the observation of a good linear correlation between the log rate constants of trans-[Ru(VI)(TMC)(O)2](2+) and p-chloranil (Cl4Q) and a large kinetic isotope effect (KIE) value of 13(1). In the case of the oxidation of alkyl hydrocarbons by the trans-[Ru(VI)(TMC)(O)2](2+) complex, the second-order rate constants were dependent on the C-H bond dissociation energy (BDE) of the substrates, and a large KIE value of 26(2) was obtained in the oxidation of xanthene and deuterated xanthene-d2 by the trans-[Ru(VI)(TMC)(O)2](2+) complex, indicating that the C-H bond activation of alkyl hydrocarbons proceeds via an H-atom abstraction in the rate-determining step.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":22560431,"openaccessinfo":{"externalids":{"MAG":"2107830496","ACL":null,"DOI":"10.1039\/c5dt00809c","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The use of constraints in types is quite natural. Yet, integrating constraint based types into the heart of a modern, statically typed, object-oriented programming language is quite tricky. Over the last five years we have designed and implemented the constrained types framework in the programming language X10. In this paper we review the conceptual design, the practical implementation issues, and the many new questions that are raised. We expect the pursuit of these questions to be a profitable area of future work.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":62518058,"openaccessinfo":{"externalids":{"MAG":"2301042050","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The function of the primitivist aesthetic in modern French culture shifted dramatically from the pre- to the post-war period. Whereas the primitivism of the Ballets russes's Le sacre du printemps was understood by its contemporaries to be radical, excessive, even prophetic and apocalyptic, the primitivism of Les noces was perceived to some extent as a manifestation of both the classicist \"call to order\" and the mechanistic aesthetic of the post-war period. Indeed, Les noces was one of many cultural products by means of which post-war modernists extolled the virtues of the machine age.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":194002520,"openaccessinfo":{"externalids":{"MAG":"2049929348","ACL":null,"DOI":"10.7202\/1015645AR","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Today Internet QoS is deployed piecemeal - typically at known bottleneck links like enterprise access links or wireless links. A more comprehensive, end-to-end QoS deployment, for instance across large enterprise networks or the global Internet, remains elusive. There is growing interest in the idea of using overlay networks to provide differential QoS services (improve performance for some flows at the expense of other flows). A necessary building block is the ability to provide differential service over a single overlay link that traverses many IP router hops. This work presents MPAT, the first truly scalable algorithm for fairly providing differential services to TCP flows that share a bottleneck link. Unlike known schemes, our approach preserves the cumulative fair share of the aggregated flows even where the number of flows in the aggregate is large. Specifically we demonstrate, primarily through experiments on the real Internet, that congestion state can be shared across more than 100 TCP flows with throughput differentials of 95:1. This is up to five times better than differentials achievable by known techniques. Indeed, MPAT scalability is limited only by the delay-bandwidth product of the aggregated flows. With this tool, it is now possible to seriously explore the viability of network QoS through overlay network services.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":12238722,"openaccessinfo":{"externalids":{"MAG":"1493588652","ACL":null,"DOI":"10.1109\/ICNP.2004.1348102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The back-attack phenomenon of the gas side blowing streams and its influence on the erosion and wear of the refractory lining during the combined side and top blowing AOD refining process of stainless steel were investigated on a water model unit of a 120 t AOD converter. Sufficiently full kinetic similarity between the model and its prototype was maintained. The influences of the gas flow rates for side and top blowing, the side tuyere position and number were examined. The preliminary industrial experiments were conducted. The results indicated that the presence of a gas top blowing jet and using of multiple tuyeres did not change the basic features of the back-attack, but could give it some distinctive behaviors. The back-attack could indeed bring about the evident and uneven erosion and wear of the lining. On the back-attack, the gas streams of the main tuyeres had a decisive role, and the subtuyere streams showed a certain suppression and alleviation effect. At a given tuyere number and position, its frequency and pressure and the total average pulse number in per unit time in the processes of this work increased with an increase in the gas side blowing rate. At a given tuyere position and gas side blowing rate, the back-attack and its influence on the erosion and wear of the lining enhanced with decreasing the tuyere number (increasing the gas flow rate for single tuyere). The gas top blowing jet could make the back-attack become more uniform and its frequency decrease, and its intensity and the total average pulse number increase; and it could reduce the eroded and worn rate of the lining at a given tuyere number and position and gas side blowing rate. The increased amplitude of the back-attack intensity and the extension of the damaged area of the lining caused by the buoyancy in a combined blowing were smaller and lower than those in a simple side blowing. As another important reason resulted in the back-attack and the erosion and wear of the lining, the effectiveness of the circulatory motion of the liquid in a combined blowing is different from that in a simple side blowing. At a given tuyere number, properly increasing the angle between each tuyere could be beneficial to alleviating the back-attack and to slowing down the erosion and wear of the lining. Under the conditions of this work, the back-attack actions and the lining eroded and worn extents and rates with 7 tuyeres and 22.5\u00b0 or 6 tuyeres and 27\u00b0 were all gentler and lower than those with the other tuyere equipments and arrangements. The results obtained from the physical modeling studies on the refining process were reliable, believable and valid. Suitably increasing the angle between each tuyere of the 120 t AOD converter could raise the life of its lining by a big margin, and remarkably improve the technical and economic indications of the process.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54614886,"openaccessinfo":{"externalids":{"MAG":"2317731508","ACL":null,"DOI":"10.2355\/ISIJINTERNATIONAL.50.1347","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of the study was to investigate and characterize the clinical presentation, and establish macroscopic diagnostic signs of diffuse axonal injury (DAI) in the early (up to 3 days) post-injury period. In DAI, coma develops immediately after head injury and persists for 3 days post-injury until death. The coma is accompanied by dominant primary stem neurological symptoms, hemodynamic and respiratory disturbances and does not progress to a vegetative state. Lifetime computed tomography reveals cerebral hemorrhage in 40.5% of cases. We established the macroscopic signs of head injury in DAI. For the postmortem diagnosis of DAI, a detailed macroscopic appearance of pathognomonic cerebral hemorrhages is given, which are most frequently (67.5%) localized in the corpus callosum (CC), namely in the area from its genu to the middle of the trunk (97%). A rational, improved scheme of excision of CC trunk areas for the histological study is proposed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251469430,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17116\/sudmed20226504124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\n\nGlobal health educational programs for medical and public health professionals have grown substantially in recent years. The University of Illinois Chicago College of Medicine (UICOM) began a global medicine (GMED) program for selected students in 2012 and has since graduated four classes. As part of the four-year curriculum, students complete a longitudinal global health capstone project. This paper describes the global health capstone project with the aims of understanding whether longitudinal capstone projects are feasible, how mentorship of capstones could be strengthened, and how participation in a capstone might contribute to students' attainment of global health competencies.\n\nMethods\n\nThe authors reviewed the final capstone projects for 35 graduates to assess features of the capstones including whether the projects were longitudinal, faculty-mentored, or involved original research. In addition, the authors assessed the attainment of each of 11 global health competency domains identified by the Consortium of Universities for Global Health (CUGH). Student reflection papers were reviewed for themes related to capstone completion.\n\nResults\n\nOf the 35 capstones, 19 (54%) were longitudinal, and 21 (60%) had subject matter-focused faculty mentorship. Twenty-six projects involved original research (74%) and 25 involved international travel (71%). Nine projects led to a conference abstract\/presentation (26%) while five led to a publication (14%). Overall, capstone projects addressed 9 out of 11 (82%) CUGH competency domains. In their reflection papers, students identified factors that facilitated capstone completion (e.g. strong mentorship), barriers to capstone completion (e.g. difficulty identifying a capstone project), and key benefits of the capstone process (e.g. strengthened research skills).\n\nConclusions\n\nA longitudinal capstone model is feasible, provides an impactful opportunity for research and career mentorship, and can teach targeted global health competencies. Further refinement of the capstone process is needed to strengthen mentorship and target more global health competencies, and additional assessment tools are needed.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":241067250,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.2.12213\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.2.12213\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Ignition of hydrogen and oxygen in the\"third limit\" is theoretically investigated in the stagnation Point flow with activation energy asymptotics. With the steady-state approximations of H, OH ,0 and \nHO\u2082, a two-step reduced kinetic mechanism is derived for the regime lower than the crossover temperature T_c at which the rates of production and consumption of all radicals are equal. Appropriate scaling of Damkohler number successfully provides the explicit relationship between pressure, temperature and strain rate at ignition. It is shown that, compared with those for the counterflow, ignition temperatures for the stagnation point flow are considerably increased with increasing the system pressure. This is because ignition in the \"third limit\" is characterized by the production of reduction of H\u2082O\u2082, which is reduced by wall effect. Strain rate substantially affects ignition tempearature because key reaction rates of H\u2082O\u2082 are comparably with its transport rate, while the mixture temperature and the hydrogen composition do not significantly affect ignition temperature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":101842117,"openaccessinfo":{"externalids":{"MAG":"2258813231","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cortical networks undergo adaptations during learning, including increases in dendritic complexity and spines. We hypothesized that structural elaborations during learning are restricted to discrete subsets of cells preferentially activated by, and relevant to, novel experience. Accordingly, we examined corticospinal motor neurons segregated on the basis of their distinct descending projection patterns, and their contribution to specific aspects of motor control during a forelimb skilled grasping task in adult rats. Learning-mediated structural adaptations, including extensive expansions of spine density and dendritic complexity, were restricted solely to neurons associated with control of distal forelimb musculature required for skilled grasping; neurons associated with control of proximal musculature were unchanged by the experience. We further found that distal forelimb-projecting and proximal forelimb-projecting neurons are intermingled within motor cortex, and that this distribution does not change as a function of skill acquisition. These findings indicate that representations of novel experience in the adult motor cortex are associated with selective structural expansion in networks of functionally related, active neurons that are distributed across a single cortical domain. These results identify a distinct parcellation of cortical resources in support of learning.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5881688,"openaccessinfo":{"externalids":{"MAG":"1976983946","ACL":null,"DOI":"10.1073\/pnas.1014335108","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3038698?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background:\n Chemoimmunotherapy is considered standard initial therapy for follicular lymphoma (FL) with high tumor burden (HTB). Obinutuzumab and Bendamustine (OB) with maintenance Obinutuzumab (mO) is considered a standard therapy for the frontline treatment of HTB FL (GALLIUM, Marcus et al, NEJM 2017). Venetoclax (VEN), an oral BCL2 inhibitor, is an attractive target in FL given the high BCL2 expression; though single agent activity has been disappointing (Davids et al. JCO 2017). BCL2 inhibition is thought to be synergistic with chemotherapy. Thus, the PrE0403 study evaluated the OB-VEN combination in frontline HTB FL. Here we present end of induction (EOI) outcomes.\n Methods:\n The primary objective of this Phase II study was to estimate the complete remission (CR) rate at EOI. Potential participants must have had a histologically confirmed diagnosis of FL grade 1, 2, or 3a with HTB defined by GELF or high risk defined by FLIPI-1 criteria. They must have had adequate performance status and organ function. Notably, creatinine clearance must have been \u226550 mL\/min. Participants must have not had prior treatment for FL.\n Eligible participants were treated with Bendamustine IV 90 mg\/m2 Day (D) 1 & 2, Obinutuzumab IV 100 mg D1, 900 mg D2, 1000 mg D8 and D15 of Cycle (C) 1 then D1 of each cycle, and VEN 800 mg orally daily D1-10 every 28 days for 6 total cycles. Due to a high rate of laboratory tumor lysis syndrome (TLS) during C1 in the first 21 patients, VEN was removed from C1 and given in C2-6 only. Participants with a CR at EOI were treated with mO IV 1000 mg D1 every 8 weeks for 2 years. Those with a partial response (PR) or stable disease (SD) were treated with mO as well as VEN 800 mg orally daily for 2 years. Pneumocystis jiroveci Pneumonia (PJP) and antiviral prophylaxis was required as was G-CSF support.\n Response was assessed via Lugano Criteria at EOI including PET\/CT and bone marrow assessment. Adverse Events (AEs) were evaluated using CTCAE v5.0. To be considered promising, OB-VEN should improve the null hypothesis CR rate of 50% (OB) to 65%. With an 85% power and a one sided 15% type I error, 56 participants would be needed with an estimated 51 eligible.\n Support for the study was from Genentech, Member of the Roche Group.\n Results\n A total of 56 participants were enrolled and treated between 12\/2017 and 11\/2020; baseline characteristics are listed in Table 1. TLS was closely monitored in C1 and 8\/21 participants developed TLS when VEN was administered in C1; 0\/35 when it was not. However, monitoring for TLS in C1 became less stringent when VEN was not administered. Treatment related Grade \u22653 toxicities occurred in 47\/56 participants (83.9%) with serious adverse events in 31 of 56 (55.5%). Atypical infections were seen; there was one treatment related death on study due to cytomegalovirus (CMV) encephalitis as well as PJP pneumonia which occurred after induction C6. Enrollment was temporarily suspended and CMV monitoring was implemented with no further occurrences. Another participant receiving mO later developed BK virus nephropathy following mO C6 and now requires ongoing hemodialysis. Another was diagnosed with Respiratory Syncytial Virus pneumonia 30 days after C6 and later PJP pneumonia after C2 of mO. Common (incidence >10%) AEs during induction are listed in Table 2. 45 of 56 (80.4%) participants were able to receive all 6 cycles of OB-VEN.\n CR was seen in 41 of 56 participants (73.2%, 2 sided 95% Confidence Interval (CI) 59.7-84.2%) at the EOI. 30 participants (53.5%) went onto maintenance. With a median follow up of 20.9 months, estimated 2 year Overall Survival (OS) and Progression-Free Survival (PFS) (90% CI) is 94.4% (82.4-98.3%) and 85.8% (68.8-93.9%) respectively.\n Conclusions\n This Phase II study of OB-VEN in untreated HTB FL showed high CR rate and met its primary endpoint with early signs of prolonged PFS. Laboratory TLS was identified but it was unclear if attributed solely to VEN, as baseline laboratory TLS rate for OB is unknown. The rate of Grade \u22653 AE of 83.9% (compared to 69% for OB in GALLIUM, Hiddeman JCO 2018) and the observation of opportunistic infections including CMV encephalitis, PJP pneumonia and BK nephropathy, suggests the combination is highly immunosuppressive. Therefore, while the study met its primary outcome, the combination of OB-VEN at 800 mg for 10 days, plus mO, does not have an acceptable risk\/benefit profile. Participants will continue to be followed for efficacy and safety during the maintenance phase.\n Figure 1 Figure 1.\n \n \n \n Portell:\u2008Acerta\/AstraZeneca: Research Funding; SeaGen: Research Funding; Pharmacyclics: Honoraria; Xencor: Research Funding; Aptitude Health: Honoraria; BeiGene: Honoraria, Research Funding; Abbvie: Research Funding; TG Therapeutics: Honoraria, Research Funding; Kite: Honoraria, Research Funding; Merck: Honoraria, Research Funding; Morphosys: Honoraria; Targeted Oncology: Honoraria; Genentech: Research Funding; VelosBio: Research Funding. Nowakowski:\u2008MorphoSys: Consultancy; Incyte: Consultancy; Kymera Therapeutics: Consultancy; TG Therapeutics: Consultancy; Blueprint Medicines: Consultancy; Nanostrings: Research Funding; Roche: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Celgene\/Bristol Myers Squibb: Consultancy, Research Funding; Zai Labolatory: Consultancy; Daiichi Sankyo: Consultancy; Bantham Pharmaceutical: Consultancy; Curis: Consultancy; Karyopharm Therapeutics: Consultancy; Selvita: Consultancy; Ryvu Therapeutics: Consultancy; Kyte Pharma: Consultancy. Cohen:\u2008Janssen, Adicet, Astra Zeneca, Genentech, Aptitude Health, Cellectar, Kite\/Gilead, Loxo, BeiGene, Adaptive: Consultancy; Genentech, BMS\/Celgene, LAM, BioINvent, LOXO, Astra Zeneca, Novartis, M2Gen, Takeda: Research Funding. Kahl:\u2008AbbVie, Acerta, ADCT, AstraZeneca, BeiGene, Genentech: Research Funding; AbbVie, Adaptive, ADCT, AstraZeneca, Bayer, BeiGene, Bristol-Myers Squibb, Celgene, Genentech, Incyte, Janssen, Karyopharm, Kite, MEI, Pharmacyclics, Roche, TG Therapeutics, and Teva: Consultancy.\n \n \n \n Venetoclax is not approved for follicular lymphoma or in combination with bendamustine and obinutuzumab","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":244558407,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1182\/blood-2021-145217","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1182\/blood-2021-145217","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Fibromuscular dysplasia (FMD) reminds of a rare form of secondary arterial hypertension occurring in young people and involving the renal arteries. FMD may also involve vertebral, subclavian, mesenteric, iliac arteries and carotid arteries. FMD of internal carotid arteries is a rare finding that is frequently incidental and asymptomatic. It usually occurs in middle\u2010aged women and is secondary to media\u2010intima fibrodysplasia. The carotid artery may be elongated or kinked and associated cerebral aneurysms have been reported. Symptoms including transient ischaemic attack or stroke are uncommon and are related to decrease of blood flow or embolization by platelet aggregates. At the onset, differential diagnosis with vasculitis must be placed. Computed tomography or magnetic resonance imaging (MRI) angiography demonstrates bilateral high\u2010grade stenosis with the characteristic \"string of beads\" pattern. Antiplatelet medication is the accepted therapy for asymptomatic lesions. Graduated endoluminal surgical dilation is an outmoded therapy, no longer used in most medical centres. Current percutaneous angioplasty is the preferred treatment for symptomatic carotid FMD, but no randomized controlled trials comparing this methodology with surgery is available. The management of a case of arterial systemic FMD in a 52\u2010year\u2010old women, diagnosed after a hypertensive crysis, is discussed. Imaging methods disclosed stenoses of carotid arteries, of celiac tripod and of superior mesenteric artery. Because of high risk associated to endovascular surgery, medical therapy was started. In the first year of follow\u2010up, no events have been reported.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8384314,"openaccessinfo":{"externalids":{"MAG":"2009543731","ACL":null,"DOI":"10.1080\/08037050802461454","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/08037050802461454?needAccess=true&role=button","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We compared immunoglobulin heavy chain gene (IGH) signal patterns in multiple myeloma (MM) using the FGFR3-IGH and the IGH break-apart probes to facilitate their understanding and analysis. Forty-nine patients with MM were studied. FISH was performed on samples sorted with an FGFR3-IGH dual-color, dual-fusion translocation probe and an IGH dual-color break-apart rearrangement probe. The IGH deletions were found in 7 MM analyzed with the FGFR3-IGH probe and all confirmed by the IGH break-apart probe. The additional IGH signals were associated with different patterns using the IGH break-apart probe: a normal pattern in 9 cases, trisomy 14 in 3 cases, and splits of IGH in 7 cases. Fusion patterns with the FGFR3-IGH probe were observed in 13 cases. Atypical patterns were identified in 6 cases with multiple presentations of IGH: a deletion of the IGH variable segment in der(4) or in chromosome 14, loss of the IGH locus in chromosome 14, and additional copies of FGFR3-IGH fusion probes. We identified a majority of atypical IGH patterns with the t(4;14) probe, without false-negative results when FGFR3-IGH signal fusions were found. However, the extrapolation of FGFR3-IGH probe signals requires the IGH break-apart probe to obtain unequivocal interpretations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37133811,"openaccessinfo":{"externalids":{"MAG":"2766591162","ACL":null,"DOI":"10.1159\/000481523","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Achebe's two novels of colonization, Things Fall Apart and Arrow of God , one written just before and one just after independence, both begin with the threat of war between village groups. In the first, war is averted by the groups themselves, negotiating compensation on the basis of reciprocity. In the second, war is not avoided and leads directly to intervention by the British, who assert a monopoly on violence and justify it on the basis of the desirability of the rule of law that they impose. I read Achebe's novels not as historical narratives but as parables of political philosophy. Reciprocity (the basis of vengeance but also of a gift economy) is opposed to the law (imposed by a sovereign and legitimized by its disinterested arbitration). The interest that Achebe expressed in models like reciprocity, which do without the state, disappeared after independence, when Nigerians had their own state. Nevertheless, both novels express a deep ambivalence about the law and the violence required to impose it.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":154850385,"openaccessinfo":{"externalids":{"MAG":"2123839333","ACL":null,"DOI":"10.1017\/PLI.2014.23","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"THE FOLLOWING case report is presented primarily to forewarn otologists of the insidious danger of using succinylcholine-drip muscle-relaxant anesthesia in any surgical procedure where the identification of the seventh cranial nerve is important to its preservation. REPORT OF CASE A 32-year-old woman had chronic left mastoiditis of 10 years' duration. The history and findings follow: severe headache for one month, dizziness and nausea for two weeks associated with a positive fistula test. A radical mastoidectomy was performed on Nov. 7th, 1955. At operation, the mastoid bone was found to be eburnated. No cells were encountered; the posterior auditory canal wall and the adjoining mastoid area were taken down to the bridge simultaneously by means of gouges and mallet. As the bridge was being thinned down, what appeared to be a mastoid cell was uncovered 1 mm. below the horizontal semicircular canal and 1 mm. behind the crest of the facial","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":20383513,"openaccessinfo":{"externalids":{"MAG":"2088622602","ACL":null,"DOI":"10.1001\/ARCHOTOL.1956.03830110071007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was designed to investigate platelet aggregation, plasma thromboxane A, and prostacyclin concentration and platelet sensitivity to prostacyclin simultaneously during the first month after myocardial infarction (MI). Spontaneous platelet aggregation and aggregation responses to ADP and adrenaline were low on the day of admission, increased rapidly by the 7th day post-MI, remained elevated during the second week post-MI and reached the level of chronic coronary artery disease patients but not healthy persons at the end of the fourth week of illness. An increase in plasma thromboxane B, the spontaneous and stable breakdown product of thromboxane A, level and enhanced prostacyclin production, with a maximum on the third post-MI day, were observed. We also demonstrated a significant platelet resistance to prostacyclin in MI patients. Thrombocyte sensitivity to prostacyclin normalized by the end of the fourth post-MI week. These results indicate the need for therapy with platelet inhibitors in patients with MI.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31121141,"openaccessinfo":{"externalids":{"MAG":"2172229931","ACL":null,"DOI":"10.3109\/09537109509078479","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Orthorexia nervosa (ON) is defined as an exaggerated, obsessive, pathological fixation on healthy food, healthy eating, or health-conscious eating behaviors. In the literature, there is an ongoing debate over whether ON should be considered simply a lifestyle phenomenon or a psychiatric disorder. In this vein, ON seems to share psychopathological characteristics with both eating disorders (EDs) and obsessive-compulsive disorder (OCD). However, there are insufficient data to reconcile the debate. The present study aimed at consolidating evidence on the clinical significance of ON and its relationship with EDs and OCD. A selective review of the literature published between January 2015 and March 2022 was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Ten studies were included. Some of these studies suggested that ON might follow a full-syndrome DSM-5 ED. Other studies proposed that ON and DSM-5 EDs may co-occur. Finally, only two studies suggested a relationship between ON and OCD. To date, the clinical significance of ON and its relationship with EDs and other DSM-5 psychiatric disorders (e.g., OCD) appears complicated and unclear. Future longitudinal research on the possible clinical course of ON is needed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253027416,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/jcm11206134","PubMedCentral":"9604819","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2077-0383\/11\/20\/6134\/pdf?version=1666616303","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This study analyzes the practice of prenatal sex selection in rural central China. It examines the prevalence and determinants of prenatal sex determination by ultrasound scanning and subsequent sex-selective abortion. The data are derived from a survey of 820 married women aged 20-44 and from in-depth interviews with rural women and men, village leaders, family planning managers, and health providers, conducted by the author in one county in central China in 2000. Prenatal sex determination was a widespread practice, especially for second and higher-order pregnancies. Sex-selective abortion was prevalent and order of pregnancy, sex of fetus, and sex of previous children were major determinants of the practice. A female fetus representing a high-order pregnancy in a family with one or more daughters was the most likely to be aborted. Awareness among rural families that in the population at large a future marriage squeeze was likely did not diminish the demand for sex-selective abortion. Copyright 2001 by The Population Council, Inc..","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":71387472,"openaccessinfo":{"externalids":{"MAG":"1997734086","ACL":null,"DOI":"10.1111\/J.1728-4457.2001.00259.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was designed to evaluate the anti-metabolic syndrome effects of capsule-filled cheonggukjang (CGJ) added with arrowroot ( Pueraria thunbergiana) extracts on body weight, adiposity and lipid metabolism in ob\/obmice. Experimental groups were normal control group (NC: basal diet), positive control group (PC: 2% CGJ), CGJ added with arrowroot extracts group (AR: 2% arrowroot in CGJ), and capsule-filled CGJ added with arrowroot extracts group (ARC: 2% arrowroot CGJ capsule). Each group was fed experimental diet for 10 weeks. Final body weight gain and atherogenic index were significantly lower in the ARC than NC group. Serum levels of total cholesterol, LDL-cholesterol, and triglycerides, blood glucose and atherogenic index were significantly lower in the ARC than NC group. Furthermore, fatty liver and regional lipid accumultion in ob\/ob mice were inhibited in the ARC group. The hepatic activities of superoxide dismutase, catalase and glutathione S-transferase were significantly higher in the ARC than NC group. Therefore, the anti-matabolic syndrome effects of the ARC group were higher than the AR group. In conclusion, these results indicated that CGJ added with arrowroot mediates its anti-obesity effects in ob\/obmice by improving lipid metabolism and antioxidant enzyme.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":83642188,"openaccessinfo":{"externalids":{"MAG":"1916644799","ACL":null,"DOI":"10.3746\/JKFN.2012.41.6.782","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo assess the visual and refractive outcomes of implantation of intrastromal corneal ring segments (ICRS) in keratoconic eyes with no coincident topographic and comatic axes.\n\n\nMETHODS\nForty-one keratoconic eyes of 39 patients with no coincident topographic and comatic axes were implanted inferiorly with a Ferrara-type ICRS (Keraring SI6; Mediphacos Inc., Belo Horizonte, Brazil) of 150\u00b0 of arc with a thickness of 150, 200, and 250 \u03bcm. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal coma-like root mean square, and residual refractive errors analyzed using vector analysis were recorded before and 6 months after the ICRS implantation.\n\n\nRESULTS\nMean UDVA was 0.76 \u00b1 0.41 logMAR before and 0.53 \u00b1 0.46 logMAR after surgery (P = .0006). CDVA was 0.13 \u00b1 0.14 logMAR before and 0.07 \u00b1 0.09 logMAR after surgery (P = .0007). Two eyes (4.9%) lost two lines or more of CDVA, 3 eyes (7.32%) lost one line, 16 eyes (39.02%) had no change in CDVA, 9 eyes (21.95%) gained one line, and 11 eyes (26.83%) gained two lines or more of CDVA. The safety index was 1.10. Spherical equivalent was significantly reduced after ICRS implantation (P < .001). Corneal coma-like root mean square changed from 0.80 \u00b1 0.53 \u03bcm before surgery to 0.61 \u00b1 0.59 \u03bcm after surgery (P = .02) for 4.5 mm of pupil size.\n\n\nCONCLUSIONS\nOne Ferrara-type ICRS of 150\u00b0 of arc with a thickness of 150, 200, or 250 \u03bcm implanted inferiorly may reduce both astigmatism and corneal coma-like aberrations in keratoconic eyes with no coincident topographic and comatic axes, providing an improvement of UDVA and CDVA values.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25276547,"openaccessinfo":{"externalids":{"MAG":"2324761612","ACL":null,"DOI":"10.3928\/1081597X-20130318-06","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:This article argues that the recent rise of \"anti-gender ideology,\" reproductive nationalism, and related discourses is best seen as an attempt to rework the boundaries of national sovereignty in a time of crisis. By focusing on the case of Estonia, the article shows how discourses which linked demographic decline to supranational, totalitarian, and utopian \"experimentation\" was articulated during the days of perestroika in 1980s Estonia, and how these ideas were later transposed onto the European Union, as a subsequent threat to national sovereignty.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":198131650,"openaccessinfo":{"externalids":{"MAG":"2957978396","ACL":null,"DOI":"10.1353\/jhi.2019.0027","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ora.ox.ac.uk\/objects\/uuid:24917a1b-fd76-46a1-8cce-b4155e9aa947\/files\/ma680880845316ace323bdc98729239c7","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This book has been motivated by an urgent need for designing and implementation of innovative control algorithms and systems for tracked vehicles. Nowadays the unmanned vehicles are becoming more and more common. Therefore there is a need for innovative mechanical constructions capable of adapting to various applications regardless the ground, air or water\/underwater environment. There are multiple various activities connected with tracked vehicles. They can be distributed among three main groups: design and control algorithms, sensoric and vision based in-formation, construction and testing mechanical parts of unmanned vehicles. Scientists and researchers involved in mechanics, control algorithms, image processing, computer vision, data fusion, or IC will find this book useful.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":86531043,"openaccessinfo":{"externalids":{"MAG":"2912409108","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For a long time, PD has been primarily considered as a motor disorder, but in the last decades, several studies have highlighted the importance of cognitive symptoms and their impact on the quality of life of the patients and their caregivers.1 ,2 That is why the identification of predictors of evolution to dementia in PD (PDD) must be a key research priority.\n\nAlthough PD-MCI does not substantially affect daily functioning, its detection is important because it may herald the subsequent development \u2026","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":196400881,"openaccessinfo":{"externalids":{"MAG":"2105910580","ACL":null,"DOI":"10.1136\/JNNP-2013-305392","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abs t rac t -The structure, chemistry and distribution of hydrothermal alteration and weathering products of feldspars and glass in 3 samples of Yucca Mountain tufts (GSW G4 borehole at a depth of 1531 ft (464 m) and USW GU3 borehole at 1406 ft (426 m) from the Calico Hills Formation and USW G4 at a depth of 272 ft (82.4 m) from the Topobah Springs Member) were examined by high-resolution transmission electron microscopy (HRTEM) and analytical electron microscopy (AEM). Alteration products are of interest because they may influence the form and distribution of contaminants released from the proposed high-level nuclear waste repository. Samples from the Calico Hills Formation contain alkalibearing aluminosilicate glass and its alteration products. Zeolites appear to have formed from compositionally similar glass by recrystallization, probably under hydrothermai conditions. Crystals are fibrous and frequently no more than a few tens of nanometers in diameter. Porous aggregates of few-nanometerdiameter, poorly crystalline silica spheres (probably opal C-T) develop adjacent to corroded glass surfaces and zeolite crystals. Finely crystalline Fe-rich smectites coat etched glass surfaces, zeolites and feldspar crystals and occur within opal-like silica aggregates. Microstructures in the clay-dominated coatings and details of smectite-glass interfaces suggest that clays grow in orientations controlled by heterogeneously retreating surfaces and from constituents released at associated glass dissolution sites. The alteration assemblage also includes finely crystalline hematite, goethite, Mn-oxide films and illite formed by alteration of muscovite. The zeolitized sample contains abundant opal-like silica whereas glass in the unzeolitized sample is weathered to smectite-like clays. These differences may be attributed to hydrological and consequent geochemical factors resulting from the higher porosity of zeolitized samples. Exsolved alkali feldspar, which occurs as micron-sized crystals in the Calico Hills Formation and as phenocrysts and in the groundmass of the devitrified Topobah Springs Member, are almost unaltered. Feldspar alteration is confined to cracks and grain boundaries, where minor, poorly crystalline, Fe-bearing aluminosilicate alteration products are developed. In these tufts, most of the porosity, permeability, high surface area and capacity to affect solution chemistry are associated with products of glass alteration. Key Words--Alteration, Clays, Coatings, Glass, Silica, Smectite, Tuff, Weathering, Yucca Mountain, Zeolites.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":214709252,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Our Galaxy is vast and awe-inspiring. The stars, planets, and our sun capture our imagination as children. For many of us, that wonder never ceases. It continues to inspire us throughout our careers and prompts us to question the evolution of our Solar System, to question what our place is within it, and how we may maintain longevity in a relatively volatile environment. To answer these questions planetary scientists turn to the study of extraterrestrial material. They analyze meteorites, impact craters, and materials returned by sample return missions for the evidence of events that are known to induce crystallographic and\/or elemental changes, or for evidence of extraterrestrial isotopic abundances that point to the age and the original source of the material. Through these studies, we can constrain timelines of events that have occurred throughout the Solar System's extensive history. Recently, atom probe tomography (APT) has been applied to the study of these materials. APT in correlation with larger-scale analysis techniques has provided insights into isotopic ratios or nanoscale distribution of elements, enriching our knowledge, and minimizing uncertainties in the time\u00a0frame of critical cosmic events. The continued use of correlative microscopy with APT for the study of planetary science, including studies of small amounts of pristine materials delivered to the Earth by exciting sample return missions, promises to provide key information into the history of our Solar System. Here, we highlight the implications of correlative microscopy with APT for the future pursuits of planetary science, we reflect on the groundbreaking research already achieved, the challenges that have been overcome to achieve these outcomes and the challenges yet to come. Graphical abstract","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":2}},"corpusid":252503768,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1557\/s43577-022-00375-6","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/link.springer.com\/content\/pdf\/10.1557\/s43577-022-00375-6.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The rate of conversion of p-nitrophenetole to p-nitrophenol by rat liver microsomes was studied. Inhibition of the reaction by CO and by SKF 525A and the absolute dependence on NADPH and oxygen indicate that cytochrome P-450 catalyzes the reaction. The apparent Km for oxygen was 0.07 microM. Furthermore, cytochrome b5 seemed to be involved in the formation of p-nitrophenol. The effect on p-nitrophenol formation of drugs known to be involved in drug interaction in clinical practice was studied. There was a competitive inhibition by phenytoin (inhibitor constant, Ki, 30 microM), disulfiram (Ki, 2 microM) and chloramphenicol (Ki, 20 microM), whereas a mixed-type inhibition by isoniazid was observed (Ki, 1,3 mM and Kii, 10,6 mM).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1335933,"openaccessinfo":{"externalids":{"MAG":"2126871074","ACL":null,"DOI":"10.1111\/J.1600-0773.1983.TB01870.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The fundamental minimum-time optimal output transition (OOT) problem is formulated in the frequency domain for systems with minimum phase stable or asymptotically stable transfer functions. The optimal post-actuated control is first solved for in the time-domain. Determination of the optimal post-actuated control is then shown to be equivalent to canceling both the zeros and poles of the system transfer function. Parameterizations of the control are proposed and solved for in closed-form for both large and small displacements of a system transfer function with a first-order zero and rigid-body dynamics. The proposed approach is then applied to a benchmark output tracking problem and an improvement in transition time is demonstrated when compared to the traditional state-to-state transition (SST) approach to determining the minimum-time control.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10232812,"openaccessinfo":{"externalids":{"MAG":"2080174662","ACL":null,"DOI":"10.1109\/ACC.2012.6314635","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND STUDY AIMS\nIncreased intra-abdominal pressure has been associated with increased intracranial pressure. Bowel insufflation during colonoscopy may increase the intra-abdominal pressure. It was hypothesized that colonoscopy may be associated with intracranial pressure elevation subsequent to an elevation in intra-abdominal pressure.\n\n\nMATERIALS AND METHODS\nColonoscopy was carried out in seven anesthetized pigs, and the colonoscope was advanced up to 60 cm from the anal verge. Insufflation was used to allow safe advancement of the colonoscope and to allow visualization of the colon, in the same way as in the procedure performed in humans. Intra-abdominal pressure was measured by determining the hydrostatic pressure in the urinary bladder. A subarachnoid screw was used to monitor intracranial pressure. The mean arterial blood pressure and intra-abdominal venous pressure were directly monitored via the femoral vessel access; all parameters were recorded before and during colonoscopy.\n\n\nRESULTS\nA statistically significant elevation in intracranial pressure was demonstrated during colonoscopy. The average increase in intracranial pressure was 3.1 mm Hg. The intra-abdominal pressure and intra-abdominal venous pressure were also significantly elevated during the procedure.\n\n\nCONCLUSIONS\nColonoscopy may increase intracranial pressure due to an increase in intra-abdominal pressure. This may have clinical implications when colonoscopy is conducted in patients with brain pathology associated with high intracranial pressure.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":21264840,"openaccessinfo":{"externalids":{"MAG":"1977012329","ACL":null,"DOI":"10.1055\/S-2004-825959","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. We discuss the impact of various tool design perspectives on defect detection sensitivity for dark-field-based extreme ultraviolet (EUV) actinic blank inspection. We consider the impact of pixel size, EUV source type, and photon collection efficiency on critical defect signal-to-noise ratio (SNR) performance. The results show that as the pixel size approaches the target defect image size, defect SNR increases, and that pixel size also determines the dominant noise source in the inspection system. Moreover, the choice of the EUV source affects the optimal numerical aperture (NA) and illumination settings. For plasma-discharged sources, more photons provided by larger partial coherent illumination can improve the defect SNR, while coherent illumination is needed to get a higher defect SNR for synchrotron-based source. In the end, we show that simply increasing the photon collection efficiency by using high-NA optics or increasing the source power cannot always improve the defect SNR. In a speckle-noise dominated situation, larger outer NA includes more noise than defect signal, thus resulting in a lower SNR. The impact of source power also saturates at a certain level as the system becomes speckle-noise limited compared to photon-noise limited.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":56094257,"openaccessinfo":{"externalids":{"MAG":"2615798843","ACL":null,"DOI":"10.1117\/1.JMM.16.2.023502","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conventional methods used to process two-dimensional discrete data will produce large errors and have a narrow scope of application. Along with the development of mathematical theories and computer technologies, some scholars propose to process twodimensional discrete data by bivariate Poisson regression model, which takes correlation among data sets into consideration and has excessive variability so that results of data analysis can be more accurate. This paper firstly introduces bivariate Poisson distribution and bivariate Poisson regression model, and then uses this model to analyze performance data of each team in regular seasons of 2013-2014 CBA (China Basketball Association) and 2012-2013 NBA (National Basketball Association), and predict performance in post seasons. Through comparison between actual results and results of double independent Poisson distribution, this model can better predict game performance.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":201851954,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\u2014 This paper describes a business game developed for a techno-economic project developed for engineering students on a Master level. This project intends to link technical challenges and a competitive business exercise, motivating students to work with the course material in a different way. The project consists of three phases. In the technical design phase, initial service set and network design are chosen. In the business game phase, strategic choices are made by selecting services, networks and pricing schemes. Finally, the evaluation phase concerns a detailed investment plan, reflecting on choices made during the first 2 phases. Students work in teams, requiring a lot of interaction. The interface is an online tool allowing multiple interaction moments. Experience with this project over the last three years showed a huge learning effect. By varying the actual use case the assignment can easily be updated year-over-year. The current paper describes an ICT solution for elderly care homes as the use case under consideration, whereas an ICT solution for schools has been implemented as well.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":250047771,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vascular anomalies are a group of disorders divided into two distinct subtypes: vascular tumors and vascular malformations. Vascular tumors are proliferative in nature, while malformations are nonproliferative. Simple, localized vascular malformations refer to a group of malformations that are localized to a single area of involvement. These simple malformations include capillary, lymphatic, venous, and arteriovenous malformations. The pediatric hematologists and oncologists are becoming increasingly involved in the diagnosis and management of these disorders. This review presents four cases as a means to discuss the diagnosis, clinical and imaging features, and management strategies of simple, localized vascular malformations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233523990,"openaccessinfo":{"externalids":{"MAG":"3152067029","ACL":null,"DOI":"10.1002\/pbc.29321","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.22541\/au.161746184.45717973\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Case: A ring-shaped meniscus (RSM) is a rare malformation of debatable origin usually occurring on the lateral meniscus. Here, we present 2 cases of RSM with differing etiologies and discuss the current literature on the topic. These reports may help with the identification of RSMs in the future and assist in understanding the true etiopathogenesis of individual cases. Conclusion: These 2 cases exemplify the variation in presentations of ring-shaped menisci and their radiological features on both x-ray and magnetic resonance imaging. This reinforces the idea that there may be both a congenital and an iatrogenic etiology to this rare condition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262102701,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2106\/JBJS.CC.23.00224","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper firstly discusses the demand of scenic area planning and new rural construction on the planning and construction of settlements. Based on the analysis of their mutual agreement and contradiction, it discusses the interactive relations between scenic areas and settlements under the backdrop of the new rural construction. With the case study of the village at the entrance of Fangshan-Changyudongtian national-grade scenic area, the paper discloses some problems commonly existing in the rural-type settlements near scenic areas and tries to find the way out and countermeasures regarding the interaction between scenic areas and settlements under the backdrop of the new rural construction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210032422,"openaccessinfo":{"externalids":{"MAG":"1018588620","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effects of finite Larmor radius (FLR) and diamagnetic drift on the current diffusive ballooning mode is studied. Starting from the reduced magnetohydrodynamic equations which include the effects of turbulent transport, the coupling with drift motion and the FLR effect of ions, we derive a ballooning mode equation with complex transport coefficients. The eigenfrequency, saturation amplitude and transport coefficients are evaluated numerically from the marginal stability condition. We found that the FLR effect increases the electron transport coefficients and that the finite drift frequency leads to the reduction of transport coefficients or the stabilization of the mode.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119831030,"openaccessinfo":{"externalids":{"MAG":"1984787278","ACL":null,"DOI":"10.1088\/0741-3335\/44\/12\/301","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A numerical algorithm for fast search of the initial phase shift on phase images with arbitrary stepwise shifts is proposed. The algorithm is based on finding the minimum deviation of the model function from the measurement results. The interval search method used directly in the proposed approach made it possible to significantly reduce the computational complexity of the algorithm. The paper presents the results of measuring a three-dimensional profile by phase triangulation methods using the proposed algorithm. The obtained results confirm the efficiency and high practical value of the proposed phase image decoding algorithm.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261433733,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ISIE51358.2023.10227911","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary 4-Carbethoxymethyl-2-[(chloroacetyl \/ \u03b1-chloropropionyl \/ \u03b1-bromobutyryl \/ \u03b1-chloro-(\u03b1-phenylacetyl)amino]thiazoles (I\u2014IV) were synthesized by reacting 4-carbethoxymethyl-2-ami-nothiazole with chloroacetyl chloride, \u03b1-chloropropionyl chloride, \u03b1-bromobutyryl bromide and \u03b1-chloro-a-phenylacetyl chloride, respectively. Furthermore, I-IV were refluxed with ammonium thiocyanate to give 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (V- VIII). V was refluxed with various aromatic aldehydes to give 5-arylidene-2-[(4-carbethoxyme-thylthiazol-2-yl)imino]-4-thiazolidinones (IX-XIV). The structures of synthesized compounds were confirmed by elemental analyses, hydrolysis, UV, IR, 1H-NMR and EI mass spectral data. The antimicrobial activities of the compounds were assessed by microbroth dilution technique using Mueller-Hinton broth and Mueller-Hinton Agar. In this study, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis and Candida albicans ATCC 10231 were used as test microorganisms. Among the tested compounds, XI and XIV showed activity against S. aureus (MIC: 78 \u00b5g\/ml, 1.6 \u00b5g\/ml), whereas compound V had an activity against S. flexneri (MIC: 39 \u00b5g\/ml) and compound I against C. albicans (MIC: 125 (|\u00b5g\/ml). Compounds I, IV- XIV were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. Only compounds I and XIV showed 86% and 67% inhibition in the primary screen.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":10333655,"openaccessinfo":{"externalids":{"MAG":"2320968900","ACL":null,"DOI":"10.1055\/s-0031-1300251","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract This study evaluated the microbiological quality and safety of food items (seafood, meat, eggs, and frozen food) supplied to elementary school food services, during delivery, and analyzed the distribution\/delivery system. To this end, 10 food items supplied by 13 factories in Daegu and Gyeongbuk were chosen for study. Beef and pork were delivered directly to schools in freezer vans. Seafood, chicken, and frozen food were delivered to schools by refrigerated vans ( \u2264 10 \u2103 ) that made other delivery stops before arriving at schools. After food was delivered to schools, total bacterial counts and coliforms (respectively) were as follows: mackerel (2.0\u00d710 2 -3.2\u00d710 5 , <5-4.0\u00d710 3 CFU\/g), common squid (2.5\u00d710 4 -6.6\u00d710 5 , 1.6\u00d710 2 -6.0\u00d710 3 CFU\/g), shellfish (3.2\u00d710 5 -1.7\u00d710 3 , 4.0\u00d710 3 -3.0\u00d710 CFU\/g), boiled fish paste (1.9\u00d710 4 , <5 CFU\/g), beef (9.2\u00d710 2 -6.4\u00d710 4 , <5-2.0\u00d710 CFU\/g), pork (2.6\u00d710 3 -1.3\u00d710 6 , <5-2.7\u00d710 2 CFU\/g), chicken (1.0\u00d710 4 , 2.4\u00d710 2 CFU\/g), egg (<5-2.3\u00d710","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":107392817,"openaccessinfo":{"externalids":{"MAG":"211206258","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A theory which can easily be used to discuss the competition between ferromagnetic order and the Kondo effect is presented in this paper. The magnetic order parameters of conduction and localized electrons as well as the hybridization term describing the Kondo effect are introduced simultaneously in a Kondo lattice model using the functional integral method. At zero temperature, quite a complete phase diagram of ferromagnetic and paramagnetic (Kondo) states is obtained in the static saddle-point approximation. At finite temperatures, the dependences of the Curie temperature and the total magnetization on the exchange-coupling strength |J| for various concentrations of conduction electrons, are also given by the theory. The main results are in qualitative agreement with experimental observations in heavy-fermion ferromagnets.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119695705,"openaccessinfo":{"externalids":{"MAG":"1985658703","ACL":null,"DOI":"10.1088\/0953-8984\/8\/42\/013","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Integral equations are derived to calculate the stresses and displacements in the neighborhood of a load-carrying rigid attachment in a shallow cylindrical shell. The integral equation formulation is simplified by modifying existing Green functions for the unbounded shell to account for simply supported boundary conditions at the ends of the vessel. The resulting equations are solved numerically. Three forces and three moments applied to the attachment are the loadings considered. Results for circular attachments agree with those found by other authors using different solution methods and with experiments.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":136540291,"openaccessinfo":{"externalids":{"MAG":"2000511503","ACL":null,"DOI":"10.1115\/1.3265616","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The QorIQ P4080 processor, the first product offered in the Freescale QorIQ P4 platform series, delivers industry leading performance under 30-watts. It combines eight Power Architecture\u2122 e500mc cores \u2014 operating at frequencies up to 1.5 GHz \u2014 with high-performance datapath acceleration logic, and network and peripheral bus interfaces. The design is in 45nm SOI technology to deliver high-performance, next-generation networking services in a very low power envelope. In addition to the applications features of the P4080 Communications Processors, the design challenges associated with bringing this sophisticated product to the market will also be described.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110510486,"openaccessinfo":{"externalids":{"MAG":"2100855783","ACL":null,"DOI":"10.1109\/ICICDT.2009.5166246","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a new method to deal with the matrix completion problem. Different from most existing matrix completion methods that only pursue the low rank of underlying matrices, the proposed method simultaneously optimizes their low rank and smoothness such that theymutually help each other and hence yield a better performance. In particular, the proposed method becomes very competitive with the introduction of a modified second-order total variation, even when it is compared with some recently emergedmatrix completionmethods that also combine the low rank and smoothness priors of matrices together. An efficient algorithm is developed to solve the induced optimization problem.The extensive experiments further confirm the superior performance of the proposed method over many state-of-the-art methods.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73648806,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Several array architectures developed at Universidad Politecnica de Madrid (UPM) for mobile phone and LMDS base \nstation antennas are presented. An eight-element array and multi-beam antennas with enhanced bandwidth have been demonstrated for GSM-UMTS. A practical implementation of a smart antenna with interference cancellation has been built for a 3er generation mobile communication system based on W-CDMA. Low-cost omnidirectional and sectored \nantennas has been developed for LMDS base station at 3 GHz. A folded three-layer printed reflectarray with shaped pattern has been demonstrated for sector LMDS base stations at 26 GHz.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":114167392,"openaccessinfo":{"externalids":{"MAG":"2587658213","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present report we studied spectral characteristics of the near-infrared combination and overtone bands of CH vibrations of a CH sequence. The near-infrared bands of the CH in CHX3 (X, halogen), which were interpreted in terms of the CH stretching and CH deformation fundamentals without any ambiguity, typically showed how the frequency and intensity of a combination or an overtone depend on the vibrational excited state. In the CH\u2013C\u2013CH of CHX2CX2CHX2, the vibrations of one CH are isolated from those of the other CH, and the combination and overtone bands were similarly interpreted as those of the CH, although each of the combination bands was split into two because of non-degeneracy of the CH deformation. In the CH\u2013CH of CHX2CHX2, the CH deformations only have coupled modes. The first combination showed four narrowly separate bands, which were reasonably interpreted on the basis of the CH stretching and the coupled CH deformation modes. We demonstrated that the first combination of coupled modes as well as the combination of up to, at least, the third order of isolated modes have the nature of the characteristic bands.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44411572,"openaccessinfo":{"externalids":{"MAG":"2064392113","ACL":null,"DOI":"10.1366\/000370205774783179","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study investigated some specific barriers and needs that online students are facing when learning English through WebEx system. It compared students' barriers and needs with their background including gender, computer ownership, and monthly allowance. It also investigated the relationship among computer aptitude, barriers and needs of online learners. The samples were 211 undergraduate students enrolled in Fundamental English course. The instrument in this study was a questionnaire. Results indicated that the levels of needs and barriers of online learners in general were moderate. There were no statistically significant differences at .05 level found in barriers and needs of online learners as classified by gender, computer ownership, and computer aptitude. As hypothesised, there was a negative relationship between computer aptitude and barriers of online learners at .01 level. Students with high computer aptitude had fewer barriers to learn online than those with low computer aptitude. In addition, there was a positive relationship between barriers and needs of online learners at .01 levels. Students with more barriers were found to have more needs to help them to learn online than those with few barriers. Teachers and institutions can take the results of this study into consideration when developing online courses.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":58417406,"openaccessinfo":{"externalids":{"MAG":"2122787164","ACL":null,"DOI":"10.17718\/TOJDE.08799","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes the factors that play the role in the high or low motivational level of adult EFL learners all over the world in general and in Saudi Arabia in particular. The study starts with the quantitative tool of 28 items survey designed on Academic Motivational Scale, administered on Likert 5-point scale at 200 adult EFL learners to measure their motivation and compare it across gender and across academic levels. With the qualitative research tools of structured interviews, all the categories of EFL teachers of various nationalities and English Language Unit administration have also been approached. The study recommends workable motivational reforms which can improve the existing scenario and raise the motivational level of Preparatory Year Programme EFL adult learners to prepare them well for the job market. The paper, unlike the previous studies which highlight the negativity only, presents both the positive and negative aspects of EFL adult learners\" motivation in learning English.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":149493881,"openaccessinfo":{"externalids":{"MAG":"2905737557","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Overall water splitting on a TiO2-based photocatalyst has been extensively investigated. However, in most cases, the products are not in a stoichiometric ratio, thus the reaction is not really overall water splitting. In this work, we found that in the presence of Cl\u2212, the evolution of O2 and H2 over Pt\/TiO2 can be successfully achieved, and the activity can be enhanced up to 3 times compared to having no Cl\u2212 present. Furthermore, the H2\u2006:\u2006O2 ratio can be close to 2.0, i.e. the stoichiometric ratio of overall water splitting. It is proposed that the Cl\u2212 ion is involved with the reaction intermediate of O2 evolution from water oxidation. Our work not only reported overall water splitting on a TiO2-based photocatalyst, but also provided experimental evidence for understanding the possible reaction process and the mechanism of photocatalytic water splitting.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":98681539,"openaccessinfo":{"externalids":{"MAG":"2110204486","ACL":null,"DOI":"10.1039\/C4CY00408F","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to assess the effect of citric acid and tetracycline HCl application to dentin surfaces by a \"passive dripping\" or an \"active burnishing\" technique. Twenty dentin blocks were prepared from freshly extracted non-diseased human impacted third molars. The blocks were root planed and randomly assigned to two groups for treatment with either citric acid or tetracycline HCl. The duration of treatment was 30, 60, 120, or 240 seconds. Control blocks were treated with distilled water. After treatment the blocks were processed for observation and measurements in the scanning electron microscope (SEM). Application of either of the acid solutions resulted in removal of the smear layer. Measurements indicated a time dependent increase in the mean dentinal tubule orifice diameter ranging from 1.05 microns in control specimens to 3.18 microns after 4 minutes treatment (citric acid group). The increase in tubule diameter was significantly greater (P less than or equal to 0.01) for both citric acid treatment modalities than tetracycline HCl treatment. There was also a time dependent increase in the depth of penetration as measured by a trumpeting of the tubule profiles, and this penetration was significantly greater (P less than or equal to 0.01) after citric acid treatments. Passive or active application of the acids did not seem to have any major impact on the measurements or on the surface morphology. It was concluded that citric acid causes more extensive changes than tetracycline HCl and that the mode of application of the agent is probably not critical.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22585645,"openaccessinfo":{"externalids":{"MAG":"2126488116","ACL":null,"DOI":"10.1902\/JOP.1992.63.4.303","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, we report on the analysis of 701 stars in a solar vicinity defined in three categories namely subsolar, solar, and supersolar with rotation periods between 1 and 70 days, based on rotational modulation signatures inferred from time series from the Kepler mission's Public Archives. In our analysis, we performed an initial selection based on the rotation period and position in the period\u2013H diagram, where H denotes the Hurst exponent extracted from fractal analysis. To refine our analysis, we applied a fractal approach known as the R\/S method, taking into account the fluctuations of the features associated with photometric modulation at different time intervals and the fractality traces that are present in the time series of our sample. In this sense, we computed the so-called Hurst exponent for the referred stars and found that it can provide a strong discriminant of rotational modulation and background noise behavior, going beyond what can be achieved with solely the rotation period itself. Furthermore, our results emphasize that the rotation period of stars is scaled by the exponent H which increases following the increase in the rotation period. Finally, our approach suggests that the referred exponent may be a powerful rotational modulation and noise classifier.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253370647,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.34117\/bjdv8n11-372","PubMedCentral":null,"ArXiv":"2211.02428"},"license":null,"url":"https:\/\/ojs.brazilianjournals.com.br\/ojs\/index.php\/BRJD\/article\/download\/54825\/40472","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In video frame rate conversion, unavailable frames are reconstructed from existing frames based on interpolated motion vectors. Due to an error in estimating motion vectors and an occlusion effect, it is possible that intensity information is not provided to every pixel in the reconstructed frame. Pixels whose intensity is missing become holes in the reconstructed frame. This paper proposes the reconstruction without distinct holes by double motion vector estimation. Motion is described by affine model instead of the conventional 2D translation model. The proposed method applies block based motion estimation. It is divided into 2 stages: frame reconstruction and hole filling. In the reconstruction stage, a new frame is reconstructed by moving blocks in previous frames according to their interpolated motion vectors. Holes in the newly reconstructed frame are then filled with the corresponding pixels in the subsequent frame. The proposed method searches for the corresponding pixels by looking for the region in the subsequent frames that are similar to the surrounding region of each hole. The computation cost in the proposed method is low because the motion estimation is simple and applied only twice. It does not use any complex processes to fill holes. Experiments on three standard video sequences showed that our proposed method reconstructed frames in complex video sequence without noticeable holes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15855556,"openaccessinfo":{"externalids":{"MAG":"1990349947","ACL":null,"DOI":"10.1109\/ISCIT.2010.5665136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Field data from south-eastern Alexander Island, Antarctica, are used to develop a model for the formation of asymmetrical valley-side slopes. Enhanced weathering and transport causes reduction in the gradient of north-facing slopes. Conversely, the relatively inactive south-facing slopes maintain their steep gradients. The application of this model to formation of the observed asymmetry in the high altitude regions of the Drakensberg mountains during the Pleistocene is considered. It is proposed that enhanced weathering and transport reduces the gradient of north-facing slopes whereas the south-facing slopes remain relatively protected environments.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":129892865,"openaccessinfo":{"externalids":{"MAG":"2070922684","ACL":null,"DOI":"10.1080\/03736245.1994.9713578","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The results of a theoretical investigation of the efficiency of degassing of the near-surface region of a material exposed to laser radiation are presented. The case of a low volume concentration of the monodispersed gas phase representing microbubbles of size no greater than 10 \u03bcm is considered. The principal parameters are revealed which determine the regimes of the egress of gas bubbles from a laser-produced melt, and analytical formulas are obtained for estimating the process rate. The analytical results are compared with the results of two-dimensional numerical simulations which include the laser heating of a solid sample, its melting, the development of thermocapillary melt convection, and the escape of gas bubbles from the melt. The analytical and numerical results are found to be in good agreement.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250746789,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1070\/QE2000v030n09ABEH001814","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"STUDY QUESTION Is an organotypic culture system able to provide the appropriate testicular microenvironment for in-vitro maturation of human immature testicular tissue (ITT)? SUMMARY ANSWER Our organotypic culture system provided a microenvironment capable of preserving seminiferous tubule (ST) integrity and Leydig cell (LC) functionality and inducing Sertoli cell (SC) maturation. WHAT IS KNOWN ALREADY Cryopreservation of human ITT is a well-established strategy to preserve fertility in prepubertal boys affected by cancer, with a view for obtaining sperm. While spermatogenesis in mice has been replicated in organotypic culture, yielding reproductively efficient spermatozoa, this process has not yet been achieved in humans. STUDY DESIGN, SIZE, DURATION The aim of this study was to in vitro mature frozen-thawed ITT. To this end, 1 mm3 tissue fragments from three prepubertal patients aged 2 (P1), 11 (P2) and 12 (P3) years were placed in organotypic culture for 139 days. Culture media, supplemented with either testosterone or hCG, were compared. PARTICIPANTS\/MATERIALS, SETTING, METHODS ST integrity and tissue viability were assessed by histological score and lactate dehydrogenase (LDH) levels in supernatants. Spermatogonia (SG), proliferating cells and proliferating SG were identified by the use of MAGE-A4 and Ki67 immunohistochemical markers. Glial cell line-derived neurotrophic factor (GDNF) was used as a marker of SC functionality, while SC maturation was evaluated by androgen receptor (AR), anti-M\u00fcllerian hormone (AMH) immunohistochemistry (IHC) and AMH immunoenzymatic assay. LC functionality was determined by testosterone levels in supernatants and by 3&bgr;-hydroxysteroid dehydrogenase (3&bgr;-HSD) IHC. Apoptosis was studied by IHC with active caspases 3 and 8 and by TUNEL (terminal deoxynubocleotidyl transferase-mediated dUTP nick end labeling) analysis. MAIN RESULTS AND THE ROLE OF CHANCE Tissue viability was preserved, as demonstrated by the decrease in and stabilization of LDH release, and evolution of ST scoring, with the percentage of well-preserved STs showing no statistical differences during culture in either medium. GDNF was expressed until Day 139, demonstrating SC functionality. Moreover, a significant reduction in AMH expression and release indicated SC maturation. Testosterone concentrations in supernatants increased in both culture media, demonstrating LC functionality with paracrine interactions. SG were present up to Day 139, although the ratio between MAGE-A4-positive cells and well-preserved tubules was significantly reduced over the course of culture (P \u2a7d 0.001). SCs exhibited a decreased proliferation rate over time (P \u2a7d 0.05). The proliferation rate of SG remained stable until Day 64, but over the total culture period (139 days), it was found to have decreased (P \u2a7d 0.05). The number of apoptotic cells did not vary during culture, nor was any statistical difference observed between the two culture media for any of the studied parameters. LARGE SCALE DATA N\/A LIMITATIONS, REASONS FOR CAUTION Loss of SG constitutes a limitation for evaluating full functionality of spermatogonial stem cells and warrants further investigation. The scarcity of human immature material is the reason for the limited amount of tissue available for experiments, precluding more comprehensive analysis. WIDER IMPLICATIONS OF THE FINDINGS Our culture system, mimicking the peripubertal testicular microenvironment with SC maturation, LC functionality and preserved paracrine interactions, and the first to use human ITT, opens the door to a deeper understanding of niche and culture conditions to obtain sperm from cryostored ITT, with the ultimate goal of restoring fertility after gonadotoxic treatments. STUDY FUNDING\/COMPETING INTEREST(S) This project was supported by a grant from the Fond National de la Recherche Scientifique de Belgique (grant T\u00e9levie N\u00b0 7.4554.14F and N\u00b0 7.4512.15F) and the Fondation Salus Sanguinis. No conflict of interest is declared.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3499688,"openaccessinfo":{"externalids":{"MAG":"2560263051","ACL":null,"DOI":"10.1093\/humrep\/dew300","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/humrep\/article-pdf\/32\/1\/32\/9971375\/dew300.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Meiosis is a highly conserved feature of sexual reproduction that ensures germ cells have the correct number of chromosomes prior to fertilization. A subset of microtubules, known as the spindle, are essential for accurate chromosome segregation during meiosis. Building evidence in mammalian systems has recently highlighted the unexpected requirement of the actin cytoskeleton in chromosome segregation; a network of spindle actin filaments appear to regulate many aspects of this process. Here we show that Drosophila oocytes also have a spindle population of actin that regulates the formation of the microtubule spindle and chromosomal movements throughout meiosis. We demonstrate that genetic and pharmacological disruption of the actin cytoskeleton has a significant impact on spindle morphology, dynamics, and chromosome alignment and segregation during the metaphase-anaphase transition. We further reveal the requirement of calcium in maintaining the microtubule spindle and spindle actin. Together, our data highlights the significant conservation of morphology and mechanism of the spindle actin during meiosis.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":251555903,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2022.08.09.503402","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1101\/2022.08.09.503402","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In 2006 the PRC significantly amended its Company Law, signaling a shift from a self-enforcing model of corporate law to one inviting broad judicial involvement in corporate disputes. This shift had very significant implications for the technical competence, institutional autonomy and political independence of the Chinese judiciary. This chapter, part of a larger study by the author on the demonstrated institutional autonomy of the Chinese People's Courts, focuses on expressions of political independence and autonomy discernable after review of more than 1000 case opinions and case outcomes in the Shanghai Municipal People's Court system. Initial findings detailed in the paper include intimations of independent court action against government entities and state-controlled enterprises and investors, and the Courts' role in protecting a semi-autonomous sphere of investment and commercial activity in the broader, and historical, context of state intervention and mandatory business regulation. Yet, there are also indications of constraints operating on the Courts, including deference to national social and economic policies over what the law commands, and the lack of engagement by the courts in respect of public company cases (whch invariably come with large groups of litigants). These constraints are the result of both bureaucratic instruction inside the Court system, and voluntary restraint by the Courts. Finally, the separate demonstrations of, and constraints on, institutional autonomy are examined, with a worrying \"authorization-constraint\" dynamic noted -- where the Shanghai Courts turn back cases based in the amended statute but not elaborated by Supreme People's Court \"regulation\", cases they accepted before the amended statute and without any superior bureaucratic explanation. This leads to a consideration of both the political forces at work on the Chinese courts, but also their basic bureaucratic identity.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":155421652,"openaccessinfo":{"externalids":{"MAG":"2256120342","ACL":null,"DOI":"10.1017\/cbo9780511809484.007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The paper seeks to shed light on the contention regarding ascertaining the financial soundness of insurance companies using a developing country as the context. It examines the current model being used by the Ghanaian regulatory and supervisory body (the National Insurance Commission, NIC) on non-life insurance companies in Ghana and compares it with the CARAMELS model including other rival theories in determining the financial health of non-life insurance companies in Ghana. The motivation of the study was that the unique format of insurance companies' financials does not lend itself to traditional financial accounting analysis. Besides, assessing financial soundness in the insurance industry is a complex task since the overall financial position of an insurance company depends on many factors, some of which are difficult to quantify. Though, recommendations as well as conclusions from past studies concerning the financial health on insurance companies are mixed, results from the study suggest that, the framework being used currently by NIC on the financial health of non-life insurance companies is not comprehensive enough to give early warnings to the industry's stakeholders and that the CARAMELS model as proposed by other authors fits the Ghanaian context and helps to bring to the fore, the generally accepted insurance core principles in the financial behaviour of non-life insurance companies in Ghana.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":166732761,"openaccessinfo":{"externalids":{"MAG":"1517563184","ACL":null,"DOI":"10.2139\/ssrn.1138338","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"When working with generative artificial intelligence (AI), users may see productivity gains, but the AI-generated content may not match their preferences exactly. To study this effect, we introduce a Bayesian framework in which heterogeneous users choose how much information to share with the AI, facing a trade-off between output fidelity and communication cost. We show that the interplay between these individual-level decisions and AI training may lead to societal challenges. Outputs may become more homogenized, especially when the AI is trained on AI-generated content. And any AI bias may become societal bias. A solution to the homogenization and bias issues is to improve human-AI interactions, enabling personalized outputs without sacrificing productivity.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":262053555,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2309.10448","PubMedCentral":null,"ArXiv":"2309.10448"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vacuum ultraviolet emissions following electron impact dissociative excitation of N2O have been studied over the wavelength range 80\u2013180 nm and for electron energies from threshold up to 300 eV. Calibrated spectral data are presented at 100 eV incident energy. The dominant N I (2p3 4S\u00b0\u20133s 4P) multiplet at 120.0 nm has a measured maximum cross section of (2.2 \u00b1 0.4) \u00d7 10\u221218 cm2 at 100 eV, which in turn was used to normalize 100 eV cross sections for all observed spectral features. In addition, excitation functions corresponding to the dominant emission features have been analysed in detail with particular emphasis on the near-threshold region. Possible dissociation channels are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119838618,"openaccessinfo":{"externalids":{"MAG":"1967602033","ACL":null,"DOI":"10.1088\/0953-4075\/41\/9\/095201","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the present work, we determine how three well documented models of the magnetospheric electric field, and two different mechanisms proposed for the formation of the plasmapause influence the radial distance, the shape and the evolution of the plasmapause during the geomagnetic storms of 28 October 2001 and of 17 April 2002. The convection electric field models considered are: McIlwain's E5D electric field model, Volland-Stern's model, and Weimer's statistical model compiled from low-Earth orbit satellite data. The mechanisms for the formation of the plasmapause to be tested are: (1) the MHD theory where the plasmapause should correspond to the last-closed-equipotential (LCE) or last-closed-streamline (LCS), if the E-field distribution is stationary or timedependent respectively; (2) the interchange mechanism where the plasmapause corresponds to streamlines tangent to a Zero-Parallel-Force surface where the field-aligned plasma distribution becomes convectively unstable during enhancements of the E-field intensity in the nightside local time sector. The results of the different time dependent simulations are compared with concomitant EUV\/IMAGE observations when available. The plasmatails or plumes observed after both selected geomagnetic storms are predicted in all simulations and for all E-field models. However, their shapes are quite different depending on the E-field models and the mechanisms that are used. Despite the partial success of the simulations to reproduce plumes during magnetic storms and substorms, there remains a long way to go before the detailed structures observed in the EUV observations during periods of geomagnetic activity can be accounted for very precisely by the existing E-field models. Furthermore, it cannot be excluded that the mechanisms currently identified to explain the formation of \"Carpenter's knee'' during substorm events, will have to be revised or complemented in the cases of geomagnetic storms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55622502,"openaccessinfo":{"externalids":{"MAG":"1974254802","ACL":null,"DOI":"10.1029\/2007JA012612","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objectives of the research are to find out and explain, the contribution of instructional leadership to the teachers' performance, contribution followership style to the teachers' performance, contribution of instructional leadership and followership style to teachers' performance in elementary school in Batahan district. This research using quantitative method with correlational approaches. The population is all the civil servant teachers in elementary school in Batahan district 110 teachers. Sample are 59 teachers by stratified proportional random sampling technique. The instrument use likert scale and the reliability 0,944. Data analysis technique is processed by using correlation and regression with help of SPSS version 20 program. Based on the analysis results can be concluded as follows: instructional leadership contributes significantly to the teachers' performance, followership style contributes significantly to the teachers' performance, instructional leadership and followership style contribute significantly to teachers' performance in elementary school in Batahan district Mandailing Natal regency, North Sumatera.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":150755357,"openaccessinfo":{"externalids":{"MAG":"2931967223","ACL":null,"DOI":"10.2991\/icla-18.2019.118","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.2991\/icla-18.2019.118","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In recent years, horizontal spatial information has received attention for its role in face perception. One study, for instance, has reported an association between horizontal tuning for faces and face identification ability measured within the same task. A possible consequence of this is that the correlation could have been overestimated. In the present study, we wanted to reexamine this question. We first measured face processing ability on the Cambridge Face Memory Test +, the Cambridge Face Perception Test, and the Glasgow Face Matching Test. A single ability score was extracted using a principal components analysis. In a separate task, participants also completed an identification task in which faces were randomly filtered on a trial basis using orientation bubbles. This task allowed the extraction of individual orientation profiles and horizontal tuning scores for faces. We then measured the association between horizontal tuning for faces and the face-processing ability score and observed a significant positive correlation. Importantly, this relation could not be accounted for by other factors such as object-processing ability, horizontal tuning for cars, or greater sensitivity to horizontal gratings. Our data give further credence to the hypothesis that horizontal facial structure plays a crucial role in face processing. (PsycINFO Database Record (c) 2019 APA, all rights reserved).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":198492032,"openaccessinfo":{"externalids":{"MAG":"2962774470","ACL":null,"DOI":"10.1037\/xhp0000684","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"New water soluble amino \u03b2-cyclodextrin-based polymer was synthesized by reaction between amino cyclodextrin derivatives and pyromellitic anhydride. This experiment presents amino derivatives, which were synthesized by attaching amino groups to \u03b2-cyclodextrins (\u03b2-CDs) used mono-6-azido-6-deoxy-\u03b2-cyclodextrin (\u03b2-CD-N3) and triphenylphosphine (Ph3P) in anhydrous N,N-dimethylformamide (DMF). An amino blocking reaction was conducted. The obtained polymer was purified by ultrafiltration. In addition, an attempt was made to create nanospheres by encapsulating the polymer with chitosan (CT) in an acidic condition. For the first time, nanospheres were obtained in the reaction between an amino \u03b2-cyclodextrin polymer and chitosan. Scanning electron microscopy (SEM). 1H NMR and ESI-MS methods for confirmation of reaction product and for structural characterization were employed. The differential scanning calorimetry (DSC) studies of polymers were also carried out.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233425680,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/polym13081332","PubMedCentral":"8073293","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-4360\/13\/8\/1332\/pdf?version=1618826128","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Biliary atresia (BA) is classically described at the neonatal age. However, rare cases of BA in older infants have also been reported. We report four cases of late-onset BA in infants older than 4 weeks (3 males, 1 female), and describe the diagnostic and management difficulties. One of the cases had a late-onset (29 weeks) presentation with a successful surgical procedure. We highlight the importance of this unusual differential diagnosis in infants with cholestatic syndrome, who may benefit from Kasai surgery, regardless of age.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12941529,"openaccessinfo":{"externalids":{"MAG":"2278151220","ACL":null,"DOI":"10.1590\/1414-431X20154808","PubMedCentral":"4763814","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present status of the field-theoretic renormalization-group (RG) approach to finite-size effects in 4He near the superfluid transition is reviewed. The perturbation theory is discussed for periodic and Dirichlet boundary conditions. Results of RG calculations of the specific heat, the superfluid density and the thermal resistance near T\u03bb are presented and compared with experimental data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123487645,"openaccessinfo":{"externalids":{"MAG":"2077413076","ACL":null,"DOI":"10.1088\/0031-8949\/1993\/T49A\/007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"legume-rhizobia symbioses, free-living rhizobia colonise root nodules and \ndevelop into N2 fixing specialists known as bacteroids. During bacteroid \ndevelopment, rhizobia must adapt to the nodule environment, consisting of reactive \noxygen species, low oxygen, antimicrobial secondary metabolites, low pH and in \nsome nodules, antimicrobial peptides. This study offers a holistic insight into the \nprocesses required by R. leguminosarum during bacteroid development in nodules \nformed on four legumes: Pisum sativum, Vicia faba, Vicia hirsuta and Phaseolus \nvulgaris. \nInitially, a high-throughput mutagenesis strategy was used to target genes \nupregulated during bacteroid development. Screening forty-two mutants on P. \nsativum identified some moderate phenotypes but more importantly, highlighted \nfunctional redundancy between certain gene products. A clear example of functional \nredundancy was seen between the Mn2+ transporters SitABCD and MntH. Single \nmutations in sitA or mntH did not cause a symbiotic phenotype whereas the double \nmutant could not form bacteroids on P. sativum, V. faba or V. hirsuta. Intriguingly, \nno symbiotic phenotype for the double mutant was observed on P. vulgaris. In \naddition to Mn2+ transporters, a Mg2+ channel, MgtE, that is essential for growth in \nMg2+-limited medium at low pH was identified. As with the Mn2+ transporters, the \nrequirement of MgtE during symbiosis depended upon the species of the hostlegume. \nReasons for host-dependent requirement of SitABCD, MntH and MgtE are \ndiscussed. \nThe requirement of three O2-responsive regulators that govern regulatory pathways \nessential to N2 fixation was also investigated. FnrN appears to be the major O2- \nresponsive regulator required for symbiosis but in addition to fnrN, two genes, fixL \nand fixLc, need to be mutated to prohibit N2 fixation. Other findings include a \nputative toxin-antitoxin system that hinders N2 fixation when disturbed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":82564797,"openaccessinfo":{"externalids":{"MAG":"1274918937","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Antimicrobial defense is an essential component of host-microbial homeostasis and contributes substantially to oral health maintenance. Dental mesenchymal stromal cells (MSCs) possess multilineage differentiation potential, immunomodulatory properties and play an important role in various processes like regeneration and disease progression. Recent studies show that dental MSCs might also be involved in antibacterial defense. This occurs by producing antimicrobial peptides or attracting professional phagocytic immune cells and modulating their activity. The production of antimicrobial peptides and immunomodulatory abilities of dental MSCs are enhanced by an inflammatory environment and influenced by vitamin D3. Antimicrobial peptides also have anti-inflammatory effects in dental MSCs and improve their differentiation potential. Augmentation of antibacterial efficiency of dental MSCs could broaden their clinical application in dentistry.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245908128,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/froh.2021.832976","PubMedCentral":"8795861","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/froh.2021.832976\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In 2002, Ken Poss discovered that zebrafish, at that time an emerging vertebrate model organism in basic research, were able to regenerate their heart upon resection of the ventricular apex. This finding set in motion a new field of research on heart regeneration, which has recently expanded in other model organisms including mammals. We interviewed Ken Poss to find out more about his motivation and vision for the future of tissue regeneration research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":49409464,"openaccessinfo":{"externalids":{"MAG":"2810548096","ACL":null,"DOI":"10.1387\/ijdb.180088fs","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1387\/ijdb.180088fs","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"A total of 1,215 barrows and gilts (PIC; 359 \u00d7 Camborough; initially 61.5 \u00b1 1.02 lb) were used in a 126-d growth trial to determine the effects of high phytase levels and feeding duration on growth performance and carcass characteristics of growingfinishing pigs. Pens of pigs were randomly assigned to 1 of 3 dietary treatments with 15 pens per treatment and 27 pigs per pen. The experimental diets were fed in four phases and based on corn, distillers dried grains with solubles (DDGS), and soybean meal. The 3 dietary treatments consisted of: 1) Control (diets formulated with no added phytase); 2) Grower phytase (diets formulated with 1,500 phytase units (FYT)\/kg added phytase fed from d 0 to 57, then no phytase from d 57 to market); and 3) Grow-finish phytase (diets formulated with 1,500 FYT\/kg added phytase fed throughout the entire study). The phytase-containing diets had the addition of 1,500 FYT\/kg of Ronozyme HiPhos 2500 (DSM Nutritional Products, Inc., Parsippany, NJ) with assumed release values of 0.146% standardized total tract digestible (STTD) P, 0.166% available P, 0.102% STTD calcium, 24 kcal\/lb of metabolizable energy, 19 kcal\/lb of net energy, and 0.0217, 0.0003, 0.00886, 0.0224, 0.0056, 0.0122, and 0.0163% digestible Lys, Met, Met + Cys, Thr, Trp, Ile, and Val, respectively. Beef tallow and feed grade amino acids were added to the diets without phytase to balance the net energy and standardized ileal digestible (SID) amino acid concentrations across treatments. During the grower period (d 0 to 57) pigs fed the control diets with no added phytase had increased average daily gain (ADG) compared to pigs fed phytase in the grower period, with pigs fed phytase in the grower and finishing stages intermediate. Pigs fed the phytase-containing diets had poorer feed efficiency (F\/G) compared to pigs fed the control diets with no phytase. During the finisher period, ADG and F\/G were similar between pigs fed the control and grower phytase treatments, and both were better (P < 0.05) than for pigs fed the phytase in grower and finisher. Overall, pigs fed diets with no phytase and pigs that were only fed phytase in the grower period had improved (P < 0.05) ADG and F\/G than pigs fed the phytase-containing diets fed until market. There was a marginally significant (P < 0.10) treatment effect on hot carcass weight (HCW), with pigs fed the control and grower phytase treatments having greater HCW than the pigs fed phytase throughout treatment. No evidence of differences (P > 0.10) were observed for other carcass characteristics. In summary, adding 1,500 FYT\/kg of phytase and using full matrix values for minerals, amino acids (AA), and energy had detrimental effects on ADG, F\/G, and HCW in this study. We speculate that the negative effects on performance of pigs fed added phytase may be due to overestimating the matrix values for energy and AA and further research is warranted.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":209464808,"openaccessinfo":{"externalids":{"MAG":"2991221772","ACL":null,"DOI":"10.4148\/2378-5977.7856","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/newprairiepress.org\/cgi\/viewcontent.cgi?article=7856&context=kaesrr","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Summary The Kenyan and N Tanzanian volcanic province contains sodic alkaline rocks ranging from melilitites and melanephelinites to transitional alkali basalts and their differentiates. Individual volcanoes display three principal magmatic suites: (i) nephelinitic; (ii) alkali basaltic; (iii) transitional basaltic. However, some large volcanoes contain more than one of these suites implying that parental magmas of variable alkalinity were available at certain times and places. A general decrease in alkalinity with time is detectable in the rift zone and for any time period there was a tendency for the least alkaline magmas to be erupted within the central and deepest part of the rift zone. Compositional variation within the suites was largely controlled by low-pressure crystalliquid fractionation. Extended fractionation produced salic differentiates. Liquid fractionation caused upward segregation of phonolitic and trachytic magmas which were erupted in preference to more mafic magmas. Isotopic data suggest that crustal contamination did not occur on a large scale.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":129169022,"openaccessinfo":{"externalids":{"MAG":"2023999965","ACL":null,"DOI":"10.1144\/GSL.SP.1987.030.01.14","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The techniques of test \ncase prioritization schedule the execution order of test cases to attain \nrespective target, such as enhanced level of forecasting the fault. The \nrequirement of the prioritization can be viewed as the en-route for deriving an \norder of relation on a given set of test cases which results from regression \ntesting. Alteration of programs between the versions can cause more test cases \nwhich may respond differently to following versions of software. In this, a \nfixed approach to prioritizing test cases avoids the preceding drawbacks. The \nJUnit test case prioritization techniques operating in the absence of coverage \ninformation, differs from existing dynamic coverage-based test case \nprioritization techniques. Further, the prioritization test cases relying on \ncoverage information were projected from fixed structures relatively other than \ngathered instrumentation and execution.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":39916154,"openaccessinfo":{"externalids":{"MAG":"2034524682","ACL":null,"DOI":"10.4236\/JSEA.2014.78057","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose of review Multiple organ failure is the main cause of morbidity and mortality in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) patients. Moreover, survivors of both ALI and ARDS often show significant neurocognitive decline at discharge. These data suggest a deleterious organ crosstalk between lungs and distal organs. This article reviews the recent literature concerning the role of this organ crosstalk during ALI, ARDS, and mechanical ventilation, especially focusing on brain\u2013lung communication. Recent findings Numerous pulmonary and extrapulmonary disorders could predispose critically ill patients to ALI and ARDS. Mechanical ventilation, although a lifesaving intervention, could contribute by modulating the mechanisms involved in the pathophysiology of lung damage and their impact on remote organs. Emerging clinical and experimental evidence supports the hypothesis of a multidirectional organ crosstalk between lungs and distal organs. Summary Organ crosstalk is an emerging area of research in lung disease in critically ill patients. The findings of these studies are clinically relevant and show the importance of an integrative approach in the management of critical patients. However, further studies are necessary to understand the complex interactions concurring in these pathologies.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":79652389,"openaccessinfo":{"externalids":{"MAG":"2605606915","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The service platforms are migrating to clouds for reasonably solving long construction periods, low resource utilizations, and isolated constructions of service platforms. However, when the migration is conducted in service clouds, there is a little focus of deploying communication-intensive applications in previous deployment methods. To address this problem, this paper proposed the combination of the online deployment and the offline deployment for deploying communication-intensive applications in service clouds. Firstly, the system architecture was designed for implementing the communication-aware deployment method for communication-intensive applications in service clouds. Secondly, in the online-deployment algorithm and the offline-deployment algorithm, service instances were deployed in an optimal cloud node based on the communication overhead which is determined by the communication traffic between services, as well as the communication performance between cloud nodes. Finally, the experimental results demonstrated that the proposed methods deployed communication-intensive applications effectively with lower latency and lower load compared with existing algorithms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9039460,"openaccessinfo":{"externalids":{"MAG":"2162460920","ACL":null,"DOI":"10.1155\/2014\/290913","PubMedCentral":"4130300","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/290913.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Greenway is a self-contained estate for social housing tenants in the North Sydney local government area of Sydney, Australia. When Greenway opened in 1954 local newspapers reported on the modern, all electric units providing living opportunities for working people.\u00a0 By 2007 social isolation and anti-social behaviour at Greenway were regularly reported by the local press.\u00a0 The revitalisation of the Greenway estate occurred with the arrival of new residents who were keen to be actively involved in community development and stand for election to the Greenway Tenants Group (GTG).\u00a0 North Sydney Council supports the GTG with grants and expertise when required and also conducts elections on behalf of the tenants group.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":151686162,"openaccessinfo":{"externalids":{"MAG":"2606103450","ACL":null,"DOI":"10.5130\/CJLG.V0I19.5488","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The meter of Greek lyric poetry shows great variation within and between lines regarding the shape, number and combinations of basic metrical units. We offer a simplifying analysis in terms of markedness, in which meters are defined by distinctive violations of linguistic constraints controlling rhythm, layering, binarity, and alignment. The constraints that are distinctively violated in meter are low ranked in the phonology of Greek.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145093026,"openaccessinfo":{"externalids":{"MAG":"2123744725","ACL":null,"DOI":"10.1017\/S0022226704003068","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Motion sickness(MS) has long been a difficult medical problem in aviation, space flight and navigation. It has become an important direction of research about how to test the efficacy of anti-motion sickness medicine(AMSM) quickly and accurately. The paper presents a fusion model by Dempster-Shafer evidence theory (DSET) for pharmacodynamic estimation of AMSM. Establishing diagnostic decision-making frame is \u0398={effective treatment, ineffective treatment, uncertain of treatment}. The decision-making parameters are divided into the nystagmus parameters and blood microcirculation parameters according to the category. Fusion result contrasts with the Graybiel score. We found that fusion results is more obvious. It shows that fusion system has higher determination, and less subjectivity influence which is disturbed by outside factors. The mathematic model can manifest the MS symptom of the quizzee. The model can acquire important reference information for further study in the pharmacodynamic estimation of AMSM.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":160033944,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Searching for natural and safe herbal tea with health benefits has attracted more and more attention, which is of great significance for reducing disease risk. A Chinese traditional herbal tea (HT) is rich in active ingredients extracted from natural plants. Numerous pharmacological studies showed that HT had the potential to improve health, including antidepression and antioxidant effects. In this study, we proposed a strategy to explore the role and underlying mechanism of HT in improving healthspan of a Caenorhabditis elegans model. First, we found that HT significantly prolonged the lifespan without reducing fertility in worms. Second, stress resistance (oxidative stress and heat stress) was enhanced and A\u03b2- and polyQ-induced toxicity was relieved significantly by HT treatment. Both fat deposition and age pigment accumulation were found to be significantly reduced in HT-treated worms. The locomotion in mid-late stages was improved, indicating that behavioral mobility was also significantly enhanced. Furthermore, the main components of HT were eighteen polyphenols and two terpenoids. Finally, it was found that this protective mechanism was positively correlated with the insulin\/insulin-like growth factor signaling- (IIS-) dependent manner, which went through promoting the nuclear localization of DAF-16 and its downstream SOD-3 expression. These results suggested that HT had an important role in improving health, which might serve as a promising healthy tea.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":230538789,"openaccessinfo":{"externalids":{"MAG":"3111165665","ACL":null,"DOI":"10.1155\/2020\/4057841","PubMedCentral":"7787765","ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/4057841.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The aim of this work was designed to investigate the effects of Multivitamin complex (MVC) on Copper oxide nano particles (nanoCuO)induced hepatotoxicity and nephrotoxicity in rats and its possible mechanism of action. The present study was performed on a forty male albino rats which were divided into four groups. Control group, MVC treated group, received Vitamins \u2013 E, C, and A in a dose of 130 mg\/kg daily by intraperitoneal injection for 2 weeks. Nano CuO induced toxic group, this group received CuO nanoparticles (40-56nm)in a dose of 10 mg\/kg daily by intraperitoneal injection for 2 weeks.MVC treated toxic group, this group received MVC in a dose of 130 mg\/kg daily by intraperitoneal injection one hour before nanoCuO injection for 2 weeks. Multivitamin Complex caused significant decrease in serum levels of ALT, AST, blood urea and serum creatinine compared to nanoCuO-induced toxic group. MVC caused significant increase in serum levels of albumin compared to nanoCuO-induced toxic group. Multivitamin Complex caused significant decrease of malondialdehyde and nitric oxide levels and significant increase in superoxide dismutase and reduced glutathione levels compared to nanoCuO toxic group.MVC improved hepatic and renal structures by histopathological examination as it caused significant decrease in fatty changes in hepatocytes, congestion, and damage of renal tubules. The results suggest that Multivitamin Complex has potential protective role against CuO nanoparticles induced hepatotoxicity and nephrotoxicity by an antioxidant mechanism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201038450,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Data security and privacy, and access control are the most security concerns arise in cloud computing. The proposed work extends hierarchical attribute-set-based Encryption (HASBE) scheme with unidirectional re-encryption which provides a more flexible, scalable, and fine-grained access control of outsourced data in cloud computing. It is a new access control scheme that allows sending the encrypted file to a particular user by keeping the grouping scheme as well. Thus the proposed scheme is useful both group scheme and individual scheme, and there is no need to maintain multiple keys for both the scheme for a user. Index Terms Access Control, Attribute Based Encryption, Unidirectional Re-encryption, Cloud Computing.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":212547623,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo assess, in an older population, the prevalence of diagnosed and undiagnosed diabetes, the number needed to screen (NNTS) to identify one individual with undiagnosed diabetes, and factors associated with undiagnosed diabetes.\n\n\nRESEARCH DESIGN AND METHODS\nSocioeconomic and health-related factors were assessed at the baseline examination of the Health, Aging, and Body Composition (Health ABC) Study, a cohort of 3,075 well-functioning people aged 70-79 years living in Memphis, Tennessee and Pittsburgh, Pennsylvania (42% blacks and 48% men). Diabetes was defined according to the 1985 World Health Organization criteria (fasting glucose > or =7.8 mmol\/l or 2-h glucose > or =11.1 mmol\/l) and the 1997 American Diabetes Association criteria (fasting glucose > or =7.0 mmol\/l).\n\n\nRESULTS\nThe prevalence of diagnosed and undiagnosed diabetes was 15.6 and 8.0%, respectively, among all participants (NNTS 10.6), 13.9 and 9.1% among white men (NNTS 9.5), 7.8 and 7.4% among white women (NNTS 12.4), 22.7 and 9.1% among black men (NNTS 8.5), and 21.6 and 6.2% among black women (NNTS 12.6). In multivariate analyses, compared with individuals without diabetes, individuals with undiagnosed diabetes were more likely to be men and were more likely to have a history of hypertension, higher BMI, and larger waist circumference. NNTS was lowest in men (9.1), individuals with hypertension (8.7), individuals in the highest BMI quartile (6.9), and individuals in the largest waist circumference quartile (6.8).\n\n\nCONCLUSIONS\nIn approximately one-third of all older people with diabetes, the condition remains undiagnosed. Screening for diabetes may be more efficient among men and individuals with hypertension, high BMI, and large waist circumference.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10565149,"openaccessinfo":{"externalids":{"MAG":"2104633420","ACL":null,"DOI":"10.2337\/DIACARE.24.12.2065","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Inherent physical properties and commercial availability makes poly(e-caprolactone) (PCL) very attractive as a potential substitute material for nondegradable polymers for commodity applications. However, a balance of toughness and stiffness is needed in order to transfer this potential into reality, particularly for short-term packaging applications. In this context, layered double hydroxide modified with palmitic acid (LDH-palmitate), was used as a nanoadditive to enhance the mechanical properties of PCL. Composites from PCL were prepared by melt-blending with LDH-palmitate loadings in the 1\u221210 wt % range. Scanning electron microscopy, transmission electron microscopy, and X-ray diffraction were used to study the structure and morphology of the composites. The results showed homogeneous dispersion of clay particles in composites, but the degree of stacking of clay platelets was related to the LDH-palmitate loadings. Charpy impact test measurements revealed an anomalous toughness improvement in the case of composite containing 5 wt % LDH-palmitate, attributed to a combination of microcavitation and changes in crystallite sizes in the composite. The addition of LDH-palmitate improved the water vapor barrier permeation of neat PCL film. In summary, LDH-palmitate was shown to have potential as a nanoadditive to obtain tougher LDH-PCL composite with improved barrier property. \u00a9 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41109.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":135833321,"openaccessinfo":{"externalids":{"MAG":"1966567839","ACL":null,"DOI":"10.1002\/APP.41109","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pir proteins are unique proteins with internal repeat sequences that are reported to be present in the cell wall of Saccharomyces cerevisiae. They are covalently attached to the cell wall and can be released by mild alkali treatment. In this study the biotinylated cell wall preparations from Candida albicans and S. cerevisiae were extracted by alkali and beta-1,3 glucanase and analyzed in parallel. Among the four bands detected by streptavidin, two proteins were recognized by the antibody to the S. cerevisiae Pir protein Hsp150. The antibody also detected a high molecular mass protein secreted in the growth medium of C. albicans. Using S. cerevisiae HSP150\/PIR2 gene as a probe, Southern and Northern hybridizations were performed with DNA and RNA of C. albicans. Hybridization with DNA digested with different restriction enzymes showed more than one hybridized fragment. An increased level of mRNA was found in heat shocked cells (37 degrees C for 45 min compared to 25 degrees C). Hybridization of ScHSP150 gene to mRNAs from cells grown in different media was also determined. Two transcripts of size approximately 3.5 kb and 2.0 kb were detected in mRNAs from cells grown in defined medium with glucose as carbon source or in the same medium supplemented with hemoglobin. The lower transcript of size 2.0 kb was absent in cells grown in medium with galactose as carbon source. A single band was also observed when cells were grown in rich medium. Together these results demonstrated the existence of beta1,3 glucan linked proteins in C. albicans, which are related to Pir family proteins of S. cerevisiae.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38182406,"openaccessinfo":{"externalids":{"MAG":"2014591513","ACL":null,"DOI":"10.1111\/J.1574-6968.2000.TB09111.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To provide a profile of the main health problems in childbearing-age women, we studied all 3,086 death certificates from the SEADE Foundation for women from 10 to 49 years of age and residing in the municipality of Campinas, from January 1, 1985, to December 31, 1994. The primary cause of death was identified and classified according to the 10th review of the ICD. Population data were obtained from the Laboratory for Epidemiological Analyses and Research, UNICAMP. One-fourth of the deaths were cardiovascular in origin, one-fifth were from external causes, and almost 20% were due to neoplasms. Maternal mortality was the ninth cause of death. External causes predominated in the 10-to-34-year age group, as compared to cardiovascular diseases and neoplasms in the 35-to-49-year group. Most alarming were the predominance of traffic accidents among causes of death in women up to age 34 (greater than AIDS during the study period) and the high mortality rate from homicides.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12838550,"openaccessinfo":{"externalids":{"MAG":"2057013986","ACL":null,"DOI":"10.1590\/S0102-311X2000000300015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this article I shall consider two seemingly contradictory claims: first, the claim that everybody who thinks that there are ordinary objects has to accept that they are vague, and second, the claim that everybody has to accept the existence of sharp boundaries to ordinary objects. The purpose of this article is of course not to defend a contradiction. Indeed, there is no contradiction because the two claims do not concern the same 'everybody'. The first claim, that all ordinary objects are vague, is a claim that stems both from common sense intuitions as well as from various types of ontologies of ordinary objects. This puts then pressure on theories of vagueness to account for the vague nature of ordinary objects \u2013 but, as we shall see, all theories of vagueness have to accept the existence of sharp thresholds. This is obvious in the case of epistemicism, and it is a well-known defect of supervaluationism, but as we will see friends of metaphysical vagueness do have to endorse the existence of sharp thresholds in their theory as well. Consequently, there are reasons for dissatisfaction with these accounts, since they do not seem to be able to do the job we asked them to do.1","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11036575,"openaccessinfo":{"externalids":{"MAG":"1500750503","ACL":null,"DOI":"10.1111\/RATI.12052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo determine the efficacy and tolerance of irinotecan in combination with fluorouracil (5-FU) plus leucovorin (LV) in patients whose disease has progressed after treatment with an oxaliplatin-based therapy.\n\n\nMATERIALS AND METHODS\nThirty-two patients were enrolled in this study from January 2000 to October 2002. Each patient's disease had progressed under oxaliplatin containing regimen. The new treatment consisted of irinotecan 150 mg\/m2 as a 90-minute infusion on day 1, LV 20 mg\/m2 bolus, given intravenously, immediately followed by a bolus of 5-FU, 400 mg\/m2, and a 22-hour continuous infusion at 600 mg\/m2 on day 1 through day 2. Treatment was repeated at 2-week intervals.\n\n\nRESULTS\nAmong the assessable 30 patients, median age was 50 years (range: 29~67), and dominant sites of metastasis were liver, lung, and lymph nodes. The objective response rate was 20%; all patients registered partial responses; 14 patients were stabilized (46.7%); and 10 had progression of disease (33.3%). Median progression-free survival was 24.6 weeks and median survival was 39.6 weeks. For the 210 cycles analyzed, NCI-CTC grades 3 and 4 hematologic toxicities were leucopenia (10%) and neutropenia (5%). Frequently occurring grade 3~4 non-hematologic adverse reactions were nausea\/ vomiting (10%), diarrhea (6.7%), stomatitis (6.7%), and alopecia (10%). There were no treatment-related deaths.\n\n\nCONCLUSION\nS: TIrinotecan in combination with 5-FU plus LV regimen is safe and effective in oxaliplatin-pretreated advanced colorectal cancer patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44882743,"openaccessinfo":{"externalids":{"MAG":"2287059327","ACL":null,"DOI":"10.4143\/crt.2003.35.2.135","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effects of pretreatment with colistin (polymyxin E) on the sensitivity of Proteus mirabilis, P. vulgaris and P. morganii strains to tris and sodium deoxycholate (DOC) have been studied. Pretreatment of two P. mirabilis strains (NCTC 60 and 4199) with low concentrations (0.25 approximately 1 microgram\/ml) of colistin rendered them sensitive to lysis by tris (0.05M) or DOC (250 approximately 1,000 microgram\/ml) although DOC induced lysis of control (non-colistin-treated) suspensions also. In contrast, the other P. mirabilis strains, as well as the P. vulgaris and P. morganii strains were little affected by tris (0.2M) or DOC (10,000 microgram\/ml) even after exposure of the cells to high colistin concentrations (up to 500 microgram\/ml). Colistin-pretreated or control cells of P. mirabilis NCTC 60 rapidly lost viability when suspended in water but not when held in 0.16M sodium chloride solution. Ethylenediamine tetraacetate-pretreated cells of strains 60 and 4199 were fairly sensitive to tris, although the extent of the lysis was less than when colistin was used as pretreating agent. One strain of P. vulgaris (NCTC 4175) became sensitive to tris and to DOC following exposure of the cells to ampicillin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24294275,"openaccessinfo":{"externalids":{"MAG":"2318195783","ACL":null,"DOI":"10.7164\/ANTIBIOTICS.31.124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"At least 2 different types of cells, hematopoietic and mesenchymal, are present in the adult bone marrow, in addition to endothelial cells. Hematopoietic and mesenchymal cells are believed to originate from hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), respectively. The bone marrow stroma, a cellular microenvironment that supports HSC, is composed of non-hematopoietic cells and contains MSC. A unique expansion of the bone marrow stroma, also known as marrow fibrosis, is the hallmark of a variety of disorders including hyperparathyroidism and fibrous dysplasia. PTH is the first bone anabolic agent approved by US Food and Drug Administration for the treatment of osteoporosis. Recent studies have suggested that PTH treatment may affect the number of hematopoietic stem cells in the bone marrow and their mobilization into the bloodstream. In addition, cells with classical features of mesenchymal stem cells\/progenitors have been shown to express receptors for PTH, and to increase in number and undergo redistribution in the adult bone marrow upon PTH treatment. In this review, we will summarize the up-to-date knowledge on PTH and its relation to stem cells. We will also discuss the contribution of different cell types to the development of marrow fibrosis and the involvement of PTH signaling in this pathology.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25865148,"openaccessinfo":{"externalids":{"MAG":"40697014","ACL":null,"DOI":"10.3275\/7620","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":". In this work, we use a test based on the differential ages of galaxies for distin-guishing the dark energy models. As proposed by Jimenez and Loeb in [1], relative ages of galaxies can be used to put constraints on various cosmological parameters. In the same vein, we reconstruct H 0 dt\/dz and its derivative ( H 0 d 2 t\/dz 2 ) using a model independent technique called non-parametric smoothing . Basically, dt\/dz is the change in the age of the object as a function of redshift which is directly linked with the Hubble parameter. Hence for reconstruction of this quantity, we use the most recent H ( z ) data. Further, we calculate H 0 dt\/dz and its derivative for several models like Phantom, Einstein de Sitter (EdS), \u039bCDM, Chevallier-Polarski-Linder (CPL) parametrization, Jassal-Bagla-Padmanabhan (JBP) parametrization and Feng-Shen-Li-Li (FSLL) parametrization. We check the consistency of these models with the results of reconstruction obtained in a model independent way from the data. It is observed that H 0 dt\/dz as a tool is not able to distinguish between the \u039bCDM, CPL, JBP and FSLL parametrizations but, as expected, EdS and Phantom models show noticeable deviation from the reconstructed results. Further, the derivative of H 0 dt\/dz for various dark energy models is more sensitive at low redshift. It is found that the FSLL model is not consistent with the reconstructed results, however, the \u039bCDM model is in concordance with the 3 \u03c3 region of the reconstruction at redshift z \u2265 0 . 3.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251064830,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes the development of a facility for evaluating the performance of small-scale particle-to-sCO2 heat exchangers, which includes an isobaric sCO2 flow loop and an electrically heated particle flow loop. The particle flow loop is capable of delivering up to 60 kW of heat at a temperature of 600 \u00b0C and flow rate of 0.4 kg\/s. The loop was developed to facilitate long duration off-sun testing of small prototype heat exchangers to produce model validation data at steady-state operating conditions. Lessons learned on instrumentation, control, and system integration from prior testing of larger heat exchangers with solar thermal input were used to guide the design of the test facility. In addition, the development and testing of a novel 20-kWt moving packed-bed particle-to-sCO2 heat exchanger using the integrated flow loops is reported. The prototype heat exchanger implements many novel features for increasing thermal performance and reducing pressure drop which include integral porting of the sCO2 flow, unique bond\/braze manufacturing, narrow plate spacing, and pure counter-flow arrangement. The experimental data collected for the prototype heat exchanger was compared to model predictions to verify the sizing, thermal performance, and pressure drop which will be extended to multi-megawatt heat exchanger designs in the future.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":237737619,"openaccessinfo":{"externalids":{"MAG":"3183828851","ACL":null,"DOI":"10.1115\/es2021-64050","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/biblio\/1841812","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Reason for Withdrawal \n \n \nThis protocol was withdrawn from The Cochrane Library issue 10, 2014 as the authors were unable to complete the overview. To view the published versions of this article, please click the 'Other versions' tab.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":71093108,"openaccessinfo":{"externalids":{"MAG":"1899364113","ACL":null,"DOI":"10.1002\/14651858.CD009343.PUB2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bill McLaren's career as a rugby commentator spanned 50 years and earned him enormous respect. He is therefore well placed to choose his all-time favourites from the world of rugby in this collection. His powers of description and huge depth of knowledge ensure that this is a comprehensive insight into rugby's most memorable moments and characters, including Jonny Wilkinson, Colin Meads, David Campese and Jean-Paul Rives.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":107334538,"openaccessinfo":{"externalids":{"MAG":"436734269","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the frame of the German Indonesian Tsunami Early Warning System (GITEWS) project a multi-frequency Global Navigation Satellite System (GNSS) Occultation & Reflectometry & Scatterometry (GORS) space receiver is developed. It is based on commercial off-the-shelf (COTS) GNSS receiver technology, as the core instrument for a future tsunami detection constellation of small low Earth orbit (LEO) satellites. For use in reflectometry, scatterometry and radio-occultation measurements as well as high-precision navigation applications, specific adaptations of the GNSS receiver firmware are desirable, which require a close interaction between scientists and the receiver manufacturer. Within the GITEWS project GFZ has set up a team consisting of GFZ, DLR and JAVAD GNSS (JAVAD) to adapt and extend their new generation GNSS receivers for advanced scientific space applications. Specific adaptations address the improvement of the cold start time-to-first-fix, the selection of optimal tracking loop parameters and channel slaving for monitoring of reflected signals. Besides pseudorange, phase and signal-to-noise measurements, the modified receiver allows output of in-phase (I) and quadrature-phase (Q) accumulations at 5 msec intervals (200 Hz). As a major step forward compared to current space receivers, the new receiver supports tracking of the civil L2C signal of the GPS constellation. An overview of the current status is given and first results are discussed. Within GITEWS the feasibility of a tsunami detection mission is studied, including the constellation mission design, the options for operating the system and the ways to develop an end-to-end system for the quick response to tsunami events. In parallel simulation studies of the GNSS signals reflected to a LEO satellite are carried out. This will be realised by a Zavorotny and Voronovich scattering model with a two-scale model approach using an Elfouhaily sea wave spectrum. An overview of the current activities is given and first results are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":9875242,"openaccessinfo":{"externalids":{"MAG":"2168691705","ACL":null,"DOI":"10.1109\/IGARSS.2007.4424005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Integrating the concept of mobility into the professional and organizational realm offers the possibility of reducing geographical disparities related to organization services. The advances made in technology, geographic information systems and pervasive systems equipped with global positioning GPS technologies have been able to bring about an evolution from classic data approaches towards the modeling of trajectory data resulting from moving activities of moving objects. As such, trajectory data needs first to be loaded into a Data Warehouse for analysis purposes. However, the traditional approaches used are poorly suited to handle spatio-temporal data features and also the decision making tasks related to mobility issues. Because of this mismatch, the authors propose to move beyond traditional approaches and propose a repository that is able to analyse trajectories of moving objects. Improving decision making and extracting pertinent knowledge with reduced costs and time expended are the main goals of this revised analysis approach. Thus, the authors propose an approach in which they employ the Bottom-up approach to modeling a Decision Support System which is designed to support Trajectory Data. As an example to illustrate this approach, the authors use a creamery and dairy milk mobile cistern application to demonstrate the effectiveness of their approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7886650,"openaccessinfo":{"externalids":{"MAG":"2585172665","ACL":null,"DOI":"10.4018\/IJISSC.2017040104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Rare Earth Elements (REE) deposits and mineralization of Turkey can be divided into four types based on their geological setting and origin. First are deposits associated with carbonatite- alkaline magmatic rocks, rich in Light Rare Earth Elements (LREE). The best known examples are the Kizilcaoren (Eskisehir) and Kuluncak (Malatya) deposits with TREE grades of 2.9% and 0.7% respectively, and typical enrichment of La-Ce. Lower grade REE mineralization at Keban (0.05% TREE) and Divrigi (0.13% TREE) is associated with abundant fluorite and all four occurrences show similar ranges for homogenization temperatures and salinities for fluid inclusions in fluorite and REE profiles. The second type are Triassic shales and the bauxites formed from them in the Bolkardagi region. Enrichment of Heavy REE (HREE) is typical and TREE grades are about 0.15% in bauxites and its protolith. These occurrences are geochemically similar to \"ion adsorption type\" deposits associated with lateritic clay on the weathered granitic rocks of China. Third is the placer type, represented by the Canakli (Burdur) deposit which is enriched in U, Th and HREE and heavy minerals such as; magnetite, zircon and rutile and has an average grade of about 0.08% TREE. The fourth potential source of REE is phosphorites. These rocks host the world's largest resources elsewhere, however the Cretaceous Mazidag deposits in Turkey are very low grade (40ppm TREE) and clearly uneconomic. Consideration of the environmental and health issues associated with exploitation and processing of REE has identified the more favorable outcomes associated with exploitation of the ion adsorption type of deposits and justification for further evaluation of the resources and processing technologies that would enable exploitation of REE-enriched bauxites in the Bolkardagi region.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":134682708,"openaccessinfo":{"externalids":{"MAG":"2968006191","ACL":null,"DOI":"10.19111\/BULLETINOFMRE.471205","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sodium aluminate and its calcinied forms have been evaluated as basic catalysts for the transesterification of waste mutton fat with methanol. The decrease in catalytic activity has been observed with calcinied sodium alumiate. Fat and methanol in 1:29 molar ratio with 1.5 wt.% of sodium aluminate under reflux resulted in 97 % conversion to biodiesel in 1h 20 min. The reaction showed tolerance of additional moisture content of 1 wt.%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21161876,"openaccessinfo":{"externalids":{"MAG":"2023416657","ACL":null,"DOI":"10.5650\/JOS.61.665","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The natural landscapes of New Zealand are a key attraction for domestic and international visitors for a variety of recreation and leisure purposes. This paper explores the interactions between heritage and recreational values for a region in New Zealand known for its sublime landscape (Bell and Lyall 2002). The paper discusses the transient movements and activities of visitors encountering this socio-cultural landscape, often seeking to view the iconic landmark - Aoraki\/Mt Cook \u2013 part of the Te Wahipounamu South West New Zealand World Heritage area \u2013 which is accessed via the Mackenzie Basin. Aoraki\/Mt Cook National Park is a wilderness region that has significance not only for local inhabitants but also for travellers sightseeing and recreating in the area. Early inhabitants of the region \u2013 M\u0101ori from the Kai Tahu iwi (tribe) - visited the Mackenzie Basin\"s numerous waterways and lakes to gather mahika kai (traditional foods) and continue to have strong associations with the area. Since European settlement in the mid 19 th century the Mackenzie landscape has been shaped by human activities, particularly farming, tourism and recreation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":134579960,"openaccessinfo":{"externalids":{"MAG":"2803374146","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A magnet system comprising a pair of self-supporting disk-shaped coils has been designed for the ASTROMAG facility on the space station Freedom. The coils are connected in a quadrupole configuration in order to eliminate their dipole moment. One of the primary requirements of this design is that the magnet coils must have near-perfect structural integrity. To this end, each coil would be manufactured as a monolithic composite in which the superconducting wire is incorporated as one of the components. By utilizing a precision X-Y numerically controlled wiring machine, the coil can be built up in pancake layers by alternating prepreg sheets of fiber\/epoxy (e.g. carbon or Kevlar fiber) with a layer of NbTi wire that spirals from OD to ID in one layer, from ID to OD in the next. and so on. Each disk magnet will have an ID of 0.4 m and an OD of 1.7 m. The peak field at the winding will be 7.2 T. The system is to operate at 1.8 K. and I\/sub op\/\/I\/sub c\/=0.5. Results of magnetic field and force calculations are presented, and the structural characteristics of the system are described.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":3}},"corpusid":122199535,"openaccessinfo":{"externalids":{"MAG":"2118327138","ACL":null,"DOI":"10.1109\/20.133668","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study investigated rehabilitation services in Nigerian prisons in Edo State of Nigeria. The study was aimed at determining the status of rehabilitation services in Nigerian prisons in Edo State. To address the problem of study, two research questions were raised. The researcher adopted a survey research design. The participants were 147 prison inmates drawn from the six Nigerian prisons of Edo State. The instrument a checklist titled \"Rehabilitation Services in Nigerian Prisons in Edo State (RSNPES)\" was administered on the participants (prison inmates). The method of data analysis was simple percentage. The study found that: Provision for rehabilitation services is still neglected and not international best practices compliance. Prison inmates of these prisons prefer one rehabilitation service to the other. The most preferred rehabilitation service is recreational activity \u2013 football. Based on these findings, it was recommended among others that deliberate efforts should be made by the Federal Government and prison service providers to reform the Nigerian prisons and make it international best practice compliance. There is also the need to introduce more rehabilitation services, facilities and reformative programmes such as training inmates on Information and Communication Technology (ICT) and giving adequate awareness programmes so as to rehabilitate prison inmates and stop recidivism.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":2}},"corpusid":12314238,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Collagen films with oriented fibrils mimic tissues that have been remodeled by fibroblasts, which naturally tend to orient collagen fibrils in vivo. We have prepared thin films of ordered fibrils of collagen I, a major component of the extracellular matrix. The films were prepared by modifying a technique previously used to produce collagen I films for studies of cell morphology and intracellular signaling. By modifying the drying step, we were able to produce thin monolayers of collagen fibrils with consistent orientations over macroscopic (>100 microm) distances. We quantified the degree of orientation of the collagen fibrils using Fourier analysis of optical microscopy images. We also conducted experiments with vascular endothelial cells, and found that cell orientation and migration are well-correlated with fibril orientation. Using polarized cells, we showed oriented thin collagen film induces natural migration along the fibrils without using any sort of attractor. Taken together, these results demonstrate additional functionality and physiological relevance for a class of films being successfully applied in a variety of cell biology experiments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19498361,"openaccessinfo":{"externalids":{"MAG":"2152278078","ACL":null,"DOI":"10.1002\/jbm.b.31039","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 101st Annual Meeting 2010\u2010\u2010 Apr 17\u201021, 2010; Washington, DC\n\np63 is the mouse homologue of the well-known tumor suppressor P53. While it remains controversial as to whether P63 functions as a tumor suppressor gene or an oncogene, mouse genetic studies and mutation analysis of human SHFM syndrome (Split Hand\/Foot Malformation) have clearly demonstrated that P63 plays an important role in skin and limb development. The truncated limbs observed in p63 null mice suggest that P63 may contribute to long bone development by playing a role during endochondral bone formation. However, how P63 regulates target gene expression and is linked to endochondral ossification remains largely unknown. Here we present some preliminary data suggesting that P63 may regulate type X collagen gene (Col10a1) expression, thereby impacting the process of chondrocyte maturation.\n\nThe type X collagen gene (Col10a1) is specifically expressed in hypertrophic chondrocytes, a critical cell stage linking both skeletal development and multiple skeletal diseases. We have previously shown that a 150-bp Col10a1 cis-enhancer is sufficient to mediate its cell-specific expression in vivo. Our further in vitro studies suggest that Runx2, a master transcription factor for osteoblast differentiation as well as for chondrocyte maturation, is one of the major factors that regulate Col10a1 expression via interaction with its tandem repeat Runx2 binding sites. Interestingly, by yeast one-hybrid approach using this cis-enhancer as bait, we identified p53 related proteins as candidate factors that may contribute to the regulation of Col10a1 expression. We have performed Real-time RT-PCR to examine p63 and Runx2 expression in MCT cells, a cell model that shows significant upregulation of Col10a1 upon growth arrest. Both p63 and Runx2 showed around 2-fold upregulation in hypertrophic MCT cells. These data suggest that P63 may collaborate with Runx2 and together regulate Col10a1 expression during chondrocyte maturation. To further explore the putative function of P63 during skeletal development, we have successfully established transgenic mouse lines in which HA and Flag tagged human TAP63\u03b1 cDNA (the longest P63 isotype) is driven by previously described hypertrophic chondrocyte-specific Col10a1 control element (Col10a1-TAP63\u03b1). By phenotypic analysis of these transgenic mice during different developmental stages, we will be able to define the consequence and the potential mechanism of P63 on skeletal development and skeletal disorders.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4972.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":84381503,"openaccessinfo":{"externalids":{"MAG":"2040018486","ACL":null,"DOI":"10.1158\/1538-7445.AM10-4972","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vaginal bleeding in early childhood, regardless of its duration and quantity, is always of clinical importance. This article discusses the examination of the child and adolescent and reviews the various causes of vaginal bleeding in these patient groups.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23969725,"openaccessinfo":{"externalids":{"MAG":"2424372559","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : This paper examines the processes that are an integral part of planning for the successful reconstruction of Iraq. The United States is spending billions of dollars on the Iraqi reconstruction effort. This effort consists of both restoring damaged areas and improving existing services to meet minimum standards. However, the resources slated for reconstruction will not last forever, and priorities will have to be established with regard to what ultimately gets accomplished. The author reviews lessons learned about reconstruction from past wars, including the Philippine War, World War II in both Europe and Japan, and the Vietnam War, and analyzes whether these lessons are still applicable today. Then he develops and analyzes four organizational structures for reconstruction that the United States may want to use to perform reconstruction and nation-building missions in Iraq. These four structures are full-time organization, standup organization, partially filled organization, and administrative organization. He explores the advantages and disadvantages of each organizational structure, how to make each one more efficient, and how to utilize each one to its fullest. The author concludes that a holistic synchronization plan is the key to successful reconstruction in Iraq. The paper also incorporates recent observations from Lieutenant General Chiarelli, previous Commander 1st Calvary Division, on his experience in full-spectrum operations in Iraq.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107538914,"openaccessinfo":{"externalids":{"MAG":"11795099","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Several related classes of operators on nilpotent Lie groups are considered. These operators involve the following features: (i) oscillatory factors that are exponentials of imaginary polynomials, (ii) convolutions with singular kernels supported on lower-dimensional submanifolds, (iii) validity in the general context not requiring the existence of dilations that are automorphisms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38266785,"openaccessinfo":{"externalids":{"MAG":"2008424040","ACL":null,"DOI":"10.1073\/PNAS.83.1.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Decentralized systems require new benchmarks and new benchmarking techniques. We propose a general methodology for benchmarking the performability of one class of decentralized system: peer-to-peer applications built on top of distributed hash tables (DHTs). Furthermore, we argue that benchmarks for decentralized systems must be designed and implemented with similar concern for scalability and robustness as the systems they are designed to benchmark, implying a need for decentralized load generation, fault injection, and metric collection. These criteria lead us to propose a benchmark implementation that uses a DHT to publish the faultload description and to store collected metrics, and uses a DHT-based relational query engine to analyze benchmark results. Finally, we argue that the fault injection and monitoring mechanisms required to run such benchmarks are reusable for online robustness testing, problem detection, and problem diagnosis, and that they therefore should be provided as infrastructure services.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":11291958,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives In this review we: (1) identify and describe nationally representative surveys with child maltreatment (CM) questions conducted by governments in low-income, middle-income and high-income countries and (2) describe procedures implemented to address respondents' safety and minimise potential distress. Design We conducted a systematic search across eight databases from 1 January 2000 to 5 July 2021 to identify original studies with information about relevant surveys. Additional information about surveys was obtained through survey methods studies, survey reports, survey websites or by identifying full questionnaires (when available). Results Forty-six studies representing 139 surveys (98 youth and 41 adult) conducted by governments from 105 countries were identified. Surveys implemented a variety of procedures to maximise the safety and\/or reduce distress for respondents including providing the option to withdraw from the survey and\/or securing confidentiality and privacy for the respondent. In many surveys, further steps were taken such as providing information for support services, providing sensitivity training to survey administrators when interviews were conducted, among others. A minority of surveys took additional steps to empirically assess potential distress experienced by respondents. Conclusions Assessing risk and protective factors and developing effective interventions and policies are essential to reduce the burden of violence against children. While asking about experiences of CM requires careful consideration, procedures to maximise the safety and minimise potential distress to respondents have been successfully implemented globally, although practices differ across surveys. Further analysis is required to assist governments to implement the best possible safety protocols to protect respondents in future surveys.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":253759882,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjopen-2022-063905","PubMedCentral":"9680163","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/12\/11\/e063905.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This study explains the women migrant workers who work abroad causing the problem towards their children that they left behind.\u00a0 It is the exclusion treatment by the community and the environment. The purpose of this study is to explain the exclusion treatment that received faced by those children from Gender Anthropology perspective. This research is descriptive research by using the qualitative method. The research conducted in Tulungagung, East Java in the form of observation, in-depth interview and Focus Group Discussion (FGD) as its data collection method. The informants who involve in this research are the women migrant workers' children and families, community leaders, Department of Human Resource Development and Culture, Child Protection Institution, Department of Social Services, Labour, and Transmigration and Department of Education. This research found that the children from women migrant workers were involved in various problems such as brawl, free sex, unwed pregnancy, drugs and mixed marriage (amalgamation) between women migrant workers with foreign men. This kind of problems causing the children from women migrant workers receives exclusion treatment from society and the environment. For instances, the children would difficult to obtain their birth certificate, receive a stigma that they are 'children souvenirs', they also unable to participate in youth organisation, do not receive their basic human rights and the rights as the citizens, such as receive proper education, health and social services. As a result, these migrant workers' children become the victims of social pressure which could affect their behaviour in the future. This research implies that the access to basic services, the space in social reconciliation and policy advocacy at various levels should be enhanced to ensure the sustainability of social inclusion for those children.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":225872727,"openaccessinfo":{"externalids":{"MAG":"3035605244","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Deexcitation energies of superdeformed secondary minima of odd-odd Au and Tl isotopes are investigated with the relativistic mean field (RMF) model where the isoscalar-isovector coupling is included to change the symmetry energy. It is verified by the theoretical analysis and numerical results that the deexcitation energies of superdeformed secondary minima relative to the ground states in these heavy nuclei are sensitive to differences in the symmetry energy. In particular, the linear correlation between the deexcitation energies of odd-odd Au and Tl isotopes and the neutron skin thickness in 208Pb is established. Moreover, explorations are extended to superdeformed candidates of other mass regions. It is found that the linear correlation can even be established between the deexcitation energies and the symmetry pressure at subsaturation density. These indicate that deexcitation energies can serve as a probe to the density dependence of the symmetry energy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120992620,"openaccessinfo":{"externalids":{"MAG":"2007245488","ACL":null,"DOI":"10.1088\/0253-6102\/54\/4\/25","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Quick diagnosis is critical for neurovascular patients. Diagnosis of these patients needs the assistance of expensive and heavily used imaging equipment. This results in long waiting time which potentially threats patient's life. It is clearly very important for the neurovascular department to improve the service level by reducing the waiting time. To deal with this problem, this paper proposes a new reservation process between the neurovascular department and the imaging department. The neurovascular department reserves a certain number of time slots in advance for the imaging techniques, i.e., magnetic resonance imaging (MRI). This ensures that the stroke patients can receive the examination more quickly. This problem is formulated as a stochastic programming model in order to reach the best comprise between patient waiting time and unused time slots. To solve this problem, a two-step Monte Carlo approach is proposed. The problem is first approximated by a deterministic Monte Carlo optimization problem. It is further simplified to determine the contract. Given the contract, we then propose a feasible control policy. Numerical results show that the contract and the control policy proposed in this paper are quite efficient.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":15371050,"openaccessinfo":{"externalids":{"MAG":"2125422473","ACL":null,"DOI":"10.1109\/COASE.2009.5234185","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"VISUALLY SALIENT STANDARDIZED COMMERCIAL DISCLOSURES ON SOCIAL MEDIA Social media have become an essential part of our everyday lives. More than 85 pct. of the Danish population from the age of 12 and up are active users of social media1. However, commercial vs. social content is difficult to discern on social media and many consumers, especially children, are unable to identify advertisements on these platforms.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":236974808,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aimed to analyze the impact of the Family Health Strategy (FHS) on oral health in Northeast Brazil, in 12 municipalities with more than 100 thousand inhabitants. The reference was 20 census tracts, 10 of which in areas with oral health covered by the FHS for at least a year, matched with 10 census tracts without oral health coverage. The total sample included 59,221 individuals. Three possible effects were considered: negative, positive, and absence of effect on the outcomes, based on the prevalence ratio adjusted by Poisson regression. The outcomes \"access to collective preventive measures\" and \"treatment of toothache\" indicate a positive effect in the FHS oral health model. However, the outcomes \"coverage of tooth extraction\" and \"restorative treatment\" showed either a negative effect or no effect in the majority of the municipalities in the sample. Evidence indicates that within the FHS, the results reflect the local organizational models for oral health care.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41350093,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In order to estimate carbon stock in natural or planted forests, it is necessary to determine wood density and carbon content. Thus, the aim of this study is to determine wood basic density and average carbon content in young Tectona grandis trees grown in commercial plantations in southeast Para. Study subjects were between four and five years old. Samples, in the form of wood discs taken at 1.3 m height from soil, were separated into bark, heartwood, and sapwood, considering two types of genetic material: clones and seeds. Basic density varied, on average, from 0.46 g cm -3 in sapwood to 0.49 g cm -3 in heartwood, and no significant difference was observed between genetic materials. Average carbon content varied from 36% in the bark to 44% in the wood, and significant differences were found between averages of the two materials. There was no significant corre\u00adlation between basic density and carbon content (r=0.3147). It was concluded that heartwood formation has early occurrence in teak, but there are no significant basic density differences between sapwood and heart\u00adwood. However, there are carbon content differences between wood and bark in the ages analyzed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":53460035,"openaccessinfo":{"externalids":{"MAG":"2555908662","ACL":null,"DOI":"10.15361\/1984-5529.2016V44N4P608-614","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate the efficiency of banks in Central and Eastern Europe. The aim is to evaluate whether foreign-owned banks are more efficient than domestic banks and can therefore play a key role in energising the emerging financial systems in transition economies. Our measures of efficiency are based on standard microeconomic theory. Using a panel of 273 foreign and domestic banks located in Bulgaria, Croatia, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland and Romania for the period 1995 \u2013 1999, we estimate a system of equations, consisting of an augmented translog cost function and two cost share equations. We calculate measures of economies and scale and scope on a bank-by-bank basis, and compare across countries and across ownership forms. The evidence we uncover suggests three main results. First, banks in our sample European transition economies exhibit a reasonable degree of efficiency overall. Second, the mean foreign bank does not appear to be significantly different from the mean domestic bank in the sample economies: we mostly reject the hypothesis that foreign banks are more efficient than domestic banks in these economies. Third, we find little or no empirical evidence to sustain the argument that bank ownership (foreign versus domestic) is an important factor in reducing the banks' total costs.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":13388655,"openaccessinfo":{"externalids":{"MAG":"799699364","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Laser-ablated nickel atoms react with dioxygen to form the primary oxides NiO and ONiO, some of which combine to form the secondary oxides Ni2O2 and ONiONiO during condensation in excess argon at 10 K. The insertion product dioxide ONiO is linear based on natural nickel and 18O isotopic substitution and DFT calculations. Annealing produces the cyclic adducts reported in earlier thermal nickel experiments and the new NiOO superoxide species, which are characterized by isotopic shifts and DFT structure and frequency calculations. In addition, dioxygen complexes with NiO and ONiO were also observed. Finally, the matrix provides sharp bands and the resolution to observe nickel isotopic splittings which characterize the Fermi-resonance interaction in the ONiOO and (O2)Ni(O2) molecules.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":96524575,"openaccessinfo":{"externalids":{"MAG":"2046041782","ACL":null,"DOI":"10.1021\/JP970019X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Traditionally, keratinocytes have been considered inert constituents of the multilayered epidermis. Today's understanding has fundamentally changed. The keratinocyte is now recognized as an active player in epidermal renewal with key functions in the skin's immune defence. Under homeostatic conditions, keratinocyte progenitor cells are believed to divide symmetrically or asymmetrically, that is they continue to proliferate or go on to terminally differentiate and build up the overlaying epidermis. The fine-tuned process of epidermal renewal relies on an extraordinary network of signalling cascades which are governed by keratinocyte-receptor interactions with the environment through paracrine and autocrine circuits. Opposing this coordinated homeostatic process are signals of wounding and inflammation. They alter the fate of the keratinocyte and its response to the environment through changes in adhesion molecules and surface receptors, in addition to triggering an immediate inflammatory keratinocyte response in terms of secretion of cytokines, chemokines and antimicrobial peptides. If uncontrolled, the fundamental changes imposed by wounding and inflammation upon the homeostatic programme can lead to severe skin lesions including chronic inflammatory disorders. This review will describe the current knowledge of the regulatory signalling network which allows the keratinocyte to actively impact both epidermal homeostasis and the inflammatory response.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12247279,"openaccessinfo":{"externalids":{"MAG":"1836110191","ACL":null,"DOI":"10.1111\/j.1365-3164.2009.00819.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The rapid efficacy of amantadine on akinesia and rigidity in Parkinson's disease is generally known. The duration of this therapeutic result is however controversial. Some authors have reported a loss of efficacy after only a few weeks of therapy. The success of a short-term parenteral and subsequently oral long-term treatment with amantadine sulphate in 8 Parkinsonian patients was tested by means of clinical and neuropsychological examinations and by monitoring the serum concentration over the course of half a year. A ten-day intravenous treatment with amantadine sulphate (200 mg daily) led to a significant improvement in the clinical and psychological test results. This attained improvement could be maintained for 6 months with oral therapy consisting of 600 mg amantadine sulphate. There were strong interindividual variations in serum concentration.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41266258,"openaccessinfo":{"externalids":{"MAG":"93384191","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An ICP-MS method using a micro-flow injection (\u03bc-FI) sample introduction system was developed for measuring 237Np and 239,240,241Pu in urine samples for sensitive and rapid population monitoring following a radiological or nuclear accident. Good selectivity from the chemical separation method allowed the determination of 237Np together with Pu isotopes using 242Pu as a tracer. Significant improvements in ICP-MS sensitivity and detection limit were achieved using the \u03bc-FI sample introduction and the desolvation techniques. The method developed has been successfully applied to a set of human urine samples spiked with Pu isotopes and a set of rat urine samples with metabolized Pu isotopes from research experiments.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":97715647,"openaccessinfo":{"externalids":{"MAG":"2122998258","ACL":null,"DOI":"10.1039\/C4JA00105B","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present the zero-shot entity linking task, where mentions must be linked to unseen entities without in-domain labeled data. The goal is to enable robust transfer to highly specialized domains, and so no metadata or alias tables are assumed. In this setting, entities are only identified by text descriptions, and models must rely strictly on language understanding to resolve the new entities. First, we show that strong reading comprehension models pre-trained on large unlabeled data can be used to generalize to unseen entities. Second, we propose a simple and effective adaptive pre-training strategy, which we term domain-adaptive pre-training (DAP), to address the domain shift problem associated with linking unseen entities in a new domain. We present experiments on a new dataset that we construct for this task and show that DAP improves over strong pre-training baselines, including BERT. The data and code are available at https:\/\/github.com\/lajanugen\/zeshel.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-30":1,"unknown":2}},"corpusid":189999659,"openaccessinfo":{"externalids":{"MAG":"2952826391","ACL":"P19-1335","DOI":"10.18653\/v1\/p19-1335","PubMedCentral":null,"ArXiv":"1906.07348"},"license":"CCBY","url":"https:\/\/www.aclweb.org\/anthology\/P19-1335.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: Fetuin-A and ghrelin have been implicated in cardiovascular diseases and mortality among end stage renal disease patients. The exact mechanisms have not been fully elucidated. There is robust data supporting an association between ghrelin and various cardiovascular conditions, and some common processes such as inflammation, oxidative stress, and endoplasmic reticulum stress have been implicated. AIM: This study was conducted to assay serum fetuin-A and ghrelin in chronic renal failure pediatric patients and to study changes in their level that may occur after a single hemodialysis. MATERIAL AND METHODS: Forty nine pediatric patients suffering from ESRD on maintenance hemodialysis (HD), 20 patients with chronic renal failure (CRF) not on dialysis and 35 healthy subjects as control group were included. The mean age of the study population was 10.58 \u00b1 3.94, 10.62 \u00b1 3.24 and 10.61 \u00b1 3.97 years respectively. Serum fetuin-A and plasma acyl ghrelin levels were measured by using ELISA method. RESULTS: The present study revealed that predialysis serum fetuin-A level was significantly increased in pediatric HD patients compared with the normal population, while ghrelin levels were significantly reduced. Furthermore, serum levels of fetuin-A decreased significantly after a single HD session. CONCLUSION: Our study concluded that fetuin-A and acyl ghrelin may play a role in inflammatory process among HD pediatric patients which may account for cardiovascular insults and mortality but their use as biochemical markers among ESRD pediatric patients have limitations due to wide fluctuations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13175217,"openaccessinfo":{"externalids":{"MAG":"1910949092","ACL":null,"DOI":"10.3889\/oamjms.2015.081","PubMedCentral":"4877825","ArXiv":null},"license":"CCBY","url":"https:\/\/www.id-press.eu\/mjms\/article\/download\/oamjms.2015.081\/497","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract This paper presents a stereo vision-based autonomous navigation system using a GPS and a modified version of the VFH algorithm. In order to obtain a high-accuracy disparity map and meet the time constraints of the real time navigation system, this work proposes the use of a semi-global stereo method. By not suffering the same issues of the regularly used local stereo methods, the employed stereo technique enables the generation of a highly dense, efficient, and accurate disparity map. Obstacles are detected using a method that checks for relative slopes and heights differences. Experimental tests using an electric vehicle in an urban environment were performed to validate the proposed approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1847903,"openaccessinfo":{"externalids":{"MAG":"2064207787","ACL":null,"DOI":"10.3182\/20130626-3-AU-2035.00045","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we develop a measure-theoretic version of the junction tree algorithm to compute desired marginals of a product function. We reformulate the problem in a measure-theoretic framework, where the desired marginals are viewed as corresponding conditional expectations of a product of random variables. We generalize the notions of independence and junction trees to collections of \/spl sigma\/-fields on a space with a signed measure. We provide an algorithm to find such a junction tree when one exists. We also give a general procedure to augment the \/spl sigma\/-fields to create independencies, which we call \"lifting.\" This procedure is the counterpart of the moralization and triangulation procedure in the conventional generalized distributive law (GDL) framework, in order to guarantee the existence of a junction tree. Our procedure includes the conventional GDL procedure as a special case. However, it can take advantage of structures at the atomic level of the sample space to produce junction tree-based algorithms for computing the desired marginals that are less complex than those GDL can discover, as we argue through examples. Our formalism gives a new way by which one can hope to find low-complexity algorithms for marginalization problems.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":9108033,"openaccessinfo":{"externalids":{"MAG":"2097922255","ACL":null,"DOI":"10.1109\/TIT.2004.828058","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The global silicon (Si) cycle plays a critical role in regulating the biological pump and the carbon cycle in the oceans. A promising tool to reconstruct past dissolved silicic acid (DSi) concentrations is the silicon isotope signature of radiolaria (\u03b430Sirad), siliceous zooplankton that dwells at subsurface and intermediate water depths. However, to date, only a few studies on sediment \u03b430Sirad records are available. To investigate its applicability as a paleo proxy, we compare the \u03b430Sirad of different radiolarian taxa and mixed radiolarian samples from surface sediments off Peru to the DSi distribution and its \u03b430Si signatures (\u03b430SiDSi) along the coast between the equator and 15\u00b0S. Three different radiolarian taxa were selected according to their specific habitat depths of 0\u201350 m (Acrosphaera murrayana), 50\u2013100 m (Dictyocoryne profunda\/truncatum), and 200\u2013400 m (Stylochlamydium venustum). Additionally, samples containing a mix of species from the bulk assemblage covering habitat depths of 0 to 400 m have been analyzed for comparison. We find distinct \u03b430Sirad mean values of +0.70 \u00b1 0.17\u2030 (Acro; 2 SD), +1.61 \u00b1 0.20 \u2030 (Dictyo), +1.19 \u00b1 0.31 \u2030 (Stylo) and +1.04 \u00b1 0.19 \u2030 (mixed radiolaria). The \u03b430Si values of all individual taxa and the mixed radiolarian samples indicate a significant (p < 0.05) inverse relationship with DSi concentrations of their corresponding habitat depths. However, only \u03b430Si of A. murrayana are correlated to DSi concentrations under normally prevailing upwelling conditions. The \u03b430Si of Dictyocoryne sp., Stylochlamydium sp., and mixed radiolaria are significantly correlated to the lower DSi concentrations either associated with nutrient depletion or shallower habitat depths. Furthermore, we calculated the apparent Si isotope fractionation between radiolaria and DSi (\u039430Si \u223c 30\u03b5 = \u03b4 30Sirad \u2212 \u03b4 30SiDSi) and obtained values of \u22121.18 \u00b1 0.17 \u2030 (Acro), \u22120.05 \u00b1 0.25 \u2030 (Dictyo), \u22120.34 \u00b1 0.27 \u2030 (Stylo), and \u22120.62 \u00b1 0.26 \u2030 (mixed radiolaria). The significant differences in \u039430Si between the order of Nassellaria (A. murrayana) and Spumellaria (Dictyocoryne sp. and Stylochlamydium sp.) may be explained by order-specific Si isotope fractionation during DSi uptake, similar to species-specific fractionation observed for diatoms. Overall, our study provides information on the taxon-specific fractionation factor between radiolaria and seawater and highlights the importance of taxonomic identification and separation to interpret down-core records.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":235663573,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fmars.2021.666896","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmars.2021.666896\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This text brings together 14 essays on reforming elementary and secondary school education in the United States that focus on measures designed to fully exploit all students' capacity to learn - even those who perform poorly on conventional intelligence tests or in traditional classroom settings. The contributors report on innovative efforts to accommodate different styles of learning among students, to encourage greater participation in educational activities by parents from minority or economically disadvantaged backgrounds, and to increase co-operation among teachers, administrators, parents, students and community members. The introduction presents an overview of the guiding principles, technical measures and political concerns critical to the success of educational reform movements. Individual chapters include assessments of specific reforms and discussions of relevant theory, recent research, and current practices and policies.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":152499037,"openaccessinfo":{"externalids":{"MAG":"569069699","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the first part of the article I outline the colonial origins of the carnivals of Santiago de Cuba and the outstanding participation of the Afro-Cuban councils for being ethnic and historical antecedents of the congas comparsas of the city. In the second part, I developed the main objective oriented to the study of the pylons, biscuits and requinto tamboras, bimembranophonic atabales that are part of the fundamental musical instrument ensembles of the orchestras of the Santiago congas.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238898540,"openaccessinfo":{"externalids":{"MAG":"3188876544","ACL":null,"DOI":"10.14482\/MENOR.40.394.25","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We discuss the problem of decomposing rectilinear regions, with or without holes, into a minimum number of rectangles. There are two different problems considered here: decomposing a figure into non-overlapping parts, called partitioning, and decomposing a figure into possibly overlapping parts, called covering. A method is outlined and proved for solving the above two problems, and algorithms for the solutions of these problems are presented. The partitioning problem can be solved in time O(n-to the 5\/2), where n is the number of vertices of the figure, whereas the covering problem is exponential in its time complexity.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119372271,"openaccessinfo":{"externalids":{"MAG":"1806232808","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Poor compliance with drug therapy is an important cause of therapeutic failure. Sixty-eight black patients with non-insulin-dependent diabetes mellitus receiving oral hypoglycaemic agents were interviewed and various factors, such as age, sex, degree of control and type of therapy, were recorded by means of a questionnaire. Compliance was determined by qualitatively assessing urine for the presence of the drugs. An alarmingly high incidence of non-compliance of 65% was found, which could still be an under-estimation because of the long half-life of one of the drugs involved--chlorpropamide. Although interesting trends were noted, no statistically significant differences between compliant and non-compliant patients were found. In the light of the high incidence of non-compliance, a larger and more detailed study seems to be warranted to identify problem areas and to plan appropriate interventions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45125359,"openaccessinfo":{"externalids":{"MAG":"2160816303","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The rigorous wave theory solution is given for the extinction efficiency and scattered intensity in the plane of the incident light beams due to a sphere in an interference pattern. The theory can be used to predict optimum angles for light collection in fringe anemometry, and applied to a novel method of particle sizing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250850823,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/7\/10\/310","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper presents an efficient method for the analysis of printed periodic structures, consisting of a multilayered array of metal patches in a stratified dielectric medium, illuminated by a uniform plane-wave. These structures are widely used as frequency selective surfaces and mirrors. The analysis is based on the solution of an integral equation by the method of moments (MoM) with entire-domain basis functions. The basis functions are calculated numerically by the boundary integral-resonant mode expansion (BI-RME) method. The patches may have an arbitrary shape, and both metal conductivity and dielectric losses are considered. Some examples are reported to show the accuracy and rapidity of the proposed method.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":123151303,"openaccessinfo":{"externalids":{"MAG":"2131177471","ACL":null,"DOI":"10.1109\/TAP.2003.817996","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ISSN: 2319-7706 Volume 7 Number 05 (2018) Journal homepage: http:\/\/www.ijcmas.com Urinary Tract Infections (UTIs) commonly occurs in pregnancy, due to the morphological and physiological changes that take place in the genitourinary tract.Asymptomatic bacteriuria refers to the presence of bacteria in urine, and is a condition in which urine culture reveals a significant growth of pathogens that is greater than 10 bacteria\/ml, but without the patient showing symptoms (Gilbert et al., 2005). The apparent reduction in immunity of pregnant women appears to encourage the growth of both commensal and non-commensal microorganisms (Scott et al., 1990). The most untoward consequence of Asymptomatic bacteriuria in pregnancy is severe renal damage. Asymptomatic bacteriuria in some woman may lead to pyelonephritis or cystitis during pregnancy, while in others there may be no symptoms of urinary tract infection through-out gestation, but may develop urinary tract infection during puerperium. Pregnancy enhances the progression from asymptomatic to symptomatic bacteriuria which could lead to pyelonephritis and adverse obstetric outcomes such as prematurity, low birth weight (Connolly and Thorp, 1999) and higher fetal mortality rates (Nicolle, 1994; Delzell and Leferre, 2000). This study therefore was carried out to determine the prevalence of Asymptomatic bacteriuria (ASB) in pregnant women and to isolate, identify the causative organisms; and to test the antimicrobial susceptibility of isolated pathogens. A total of 200 pregnant women who came for ante-natal checkup in outpatient department at Govt. Maternity Hospital, Nayapool. Hyderabad were studied over a period of one year. Clean catch midstream urine sample was collected into a sterile container and then subjected to culture method. Out of 200 patients studied, significant bacteriuria was noted in 36 (18%) cases and 8(4%) patients had insignificant bacteriuria. Highest incidence of 22 cases (61.11%) were reported in the age group of 26-35 years. It was found that Asymptomatic bacteriuria showed significant increase with respect to parity, higher incidence was seen in multi gravidae 58.9% (3 and 4th parity). Incidence of Asymptomatic bacteriuria was found to decrease with the increase in gestation time, maximum number were noted in first trimester 19 (52.78%) followed next by second trimester 13 (36.11%) and in third trimester 4 (11.11%). E. coli 20 (55.56%),was the most common etiological agent followed by Klebsiella spp in 9 cases (25%) Coagulase negative Staphylococcus in 2 cases (5.56%) and Pseudomonas spp in 2 cases (5.56%), Proteus mirabilis and Enterobacter, Staphylococcus aureus each in one case (2.78%) all the strains were sensitive to imipenem and meropenem. As asymptomatic bacteriuria is associated with complications in pregnancy, it is therefore imperative that pregnant women be screened for bacteriuria, periodically in every trimester of the gestational period. Routine urine culture tests should be carried out for all antenatal women to detect asymptomatic bacteriuria, and every positive case should be treated with appropriate antibiotic therapy, to prevent any obstetric complication which is associated with pregnancy. In view of changing patterns of bacterial resistance to common drugs, the importance of educating physicians on use of antibiotics accordingly to provide empirical therapy is important. K e y w o r d s UTI, Asymptomatic bacteruria, E. coli Accepted: 10 April 2018","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":81786819,"openaccessinfo":{"externalids":{"MAG":"2803890298","ACL":null,"DOI":"10.20546\/IJCMAS.2018.705.138","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Apparent digestibility (ADC) of five isoproteic and isoenergetic diets containing 0, 0.1, 0.2, 0.3, and 0.4g\/kg of enzymatic complex Bioenzimaplus (lipase, protease, and carbohydrase) for Nile tilapia was evaluated. A hundred fish were randomly assigned in five feeding aquaria, and five collecting feces ones. Treatments were composed by five enzymatic complex levels arranged in a completely randomized design in five repetitions. Significant differences (P<0.05) were observed with the inclusion of enzymatic complex in the diets for ADC of crude protein and fat (linear effect). ADC of crude protein and fat varied from 81.60% to 84.94% and 74.19% to 85.69%, respectively. The highest enzyme supplementation level showed better digestibility values for carbohydrate and gross energy (57.85% and 63.78%, respectively). No difference was observed for ADC of dry matter showing values between 49.47% and 58.55%. The use of enzymes in Nile tilapia diets improved the digestibilities of protein, fat, carbohydrate, and gross energy digestibility.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":82699764,"openaccessinfo":{"externalids":{"MAG":"164117451","ACL":null,"DOI":"10.1590\/S0102-09352009000600020","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A panel of professionals from the ranching, environmental, agency, and university communities was assembled to examine trends relating to the future of grazing on federal lands. Five factors were identified that were thought to influence the use of grazed forages over the next 20 years. These factors were (1) multiple uses of public land, (2) public sentiment towards grazing on public lands, (3) environmental and federal agency regulations, (4) permittee issues, and (5) use of science and technology for managing public land grazing. A list of issues associated with each of the five factors was concurrently developed. The panel of experts was surveyed to explore the future direction each issue would take and the influence each issue may exert on grazing on public lands. All four groups were fairly consistent on the way they viewed the future of grazing on public lands. The most likely scenario includes (1) a significant increase in the demand for multiple uses on public lands, (2) a continued public sentiment against grazing on public lands, (3) and increase in the regulations, and their enforcement, that will negatively impact livestock grazing on the majority of allotments, (4) a continued demand or slight decline in rancher demand for grazing on public lands, and (5) a significant increase in the use of science and technology for managing public land grazing.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":91180004,"openaccessinfo":{"externalids":{"MAG":"2157815996","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We demonstrated two experimental methods of producing and guiding pulsed atomic beams on chip. One is to trap atoms first in a U-type magneto-optical trap on the chip, then transfer them to the magnetic guide field and push them simultaneously by a continuous force from the power imbalance of the magneto-optical trap laser beams hence the pulsed cold atom beams are produced and move along the magnetic guide to the destination. The other is to trap atoms directly by a H-type magneto-optical trap, then push them to make them move along the magnetic guide field, thus high rate cold atom beams can be produced and guided on the chip.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250893247,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1674-1056\/19\/2\/023204","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: The influence of sex hormones on intraocular pressure (IOP) has been the focus of recent debate. Previous studies investigating the effects of hormone therapy (HT) on IOP in postmenopausal women have produced conflicting results but have been limited by small numbers of participants. The aim of our study was to compare IOP in women without glaucoma taking HT with those not taking HT. Methods: A prospective cross-sectional study of postmenopausal women visiting a single ophthalmic medical practitioner was conducted. All women with a history of intraocular disease, a family history of glaucoma, or refractive error exceeding \u00b15 diopters were excluded. Applanation tonometry was used to measure IOP, and participants were then asked if they were current HT users. Results: A total of 263 participants were recruited, of whom 91 reported current use of HT; 172 had never used HT. Within the HT group, 33 were taking an estrogen-therapy and 58 were taking a estrogen-progesterone therapy. Mean IOP in the HT group was significantly lower than that in the non-HT group; the mean difference was 1.41 mm Hg (P < 0.001). This difference remained statistically significant after statistical correction for age, use of systemic &bgr;-blockers, and time of IOP measurement. There was no significant difference in mean IOP between women taking combined versus those taking estrogen-only preparations. Conclusions: Our study showed that IOP was significantly lower in women taking HT than in those who had never taken HT, even after removing other possible influences on IOP. The IOP-lowering effect of HT deserves further investigation to explore whether it may represent a possible new therapeutic modality for glaucoma.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":5274002,"openaccessinfo":{"externalids":{"MAG":"2056663388","ACL":null,"DOI":"10.1097\/gme.0b013e3181b82fb4","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The purpose of the study was to find out whether or not there was a significant difference in reading comprehension between the students who were taught by using THIEVES (Title, Heading, Introduction, Every first sentence, Visual, End of paragraph, Summary) strategy and that of those who were not.The quasi-experimental method was used to conduct the research. The population of the study was all of the eighth-grade students of SMPN 2 Teluk Gelam. In this study, the purposive sampling method was used.The total numbers of the samples were 62 students. The instrument of this research was 30 questions about recount text in the form of multiple-choice test. To analyze the data, t-test was used. Based on the result of independent sample t-test, the value of tobtained was 3.718 at significance level p<0.05 in two-tailed testing and df=60, the critical value of ttable was 2.0003. Since the value of tobtained (3.718) was higher than ttable (2.0003) and pvalue (0.000) was less than \u03b1value 0.05, it meant that there was a significant difference in reading comprehension between the students who were taught using THIEVES strategy and that of those who were not. Hence, THIEVES strategy could improve the eighth-grade students' reading skill at SMP Negeri 2 Teluk Gelam.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":212876808,"openaccessinfo":{"externalids":{"MAG":"2997789758","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract In this paper, a deep convolutional neural network (CNN) is developed to classify the Unmanned Aerial Vehicle (UAV) derived multispectral imagery and normalized digital surface model (DSM) data in urban areas. For this purpose, a multi-input deep CNN (MIDCNN) architecture is designed using 11 parallel CNNs; 10 deep CNNs to extract the features from all possible triple combinations of spectral bands as well as one deep CNN dedicated to the normalized DSM data. The proposed method is compared with the traditional single-input (SI) and double-input (DI) deep CNN designations and random forest (RF) classifier, and evaluated using two independent test datasets. The results indicate that increasing the CNN layers parallelly augmented the classifier's generalization and reduced overfitting risk. The overall accuracy and kappa value of the proposed method are 95% and 0.93, respectively, for the first test dataset, and 96% and 0.94, respectively, for the second test data set.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":237727089,"openaccessinfo":{"externalids":{"MAG":"3185991925","ACL":null,"DOI":"10.1080\/10106049.2021.1959655","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Familial hypercholesterolemia (FH) is an autosomal-dominant genetic disease characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature atherosclerotic coronary heart disease (CHD). Patients with FH in Hong Kong were found by the identification of potential probands with primary hypercholesterolemia manifesting total cholesterol levels greater than 7.5 mmol\/L or LDL-C levels greater than 4.9 mmol\/L and undertaking cascade screening of available relatives in the Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong since the early 1990s. Our previous study in a group of 252 subjects from 87 pedigrees clinically diagnosed as having heterozygous FH reported the mean plasma LDL-C level as 7.2\u00b11.5 mmol\/L. Xanthomata were present in 40.6% of males and 54.8% of females. The prevalence of known CHD was relatively low at 9.9% in males and 8.5% in females. All FH patients were offered treatment with statins and many of them reached the LDL-C goal with a moderate or high dose of potent statin alone. Ezetimibe is usually added for patients who have not achieved target LDL-C levels on statin alone, particularly in patients with established CHD. Some FH patients who have not achieved the LDL-C targets with this combination have entered into clinical trials with new cholesterol-modifying agents such as the monoclonal antibodies to proprotein convertase subtilisin-kexin type 9. Increased awareness, early identification, and optimal treatment are essential to reduce the risk of CHD, increase life expectancy, and improve the quality of life of patients with FH.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-30":1,"unknown":2}},"corpusid":207531905,"openaccessinfo":{"externalids":{"MAG":"2278727683","ACL":null,"DOI":"10.5551\/jat.34314","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/23\/5\/23_34314\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Pancreatic neuroendocrine tumors (PNETs) are relatively rare and generally considered to follow an indolent course. However poorly differentiated or metastatic PNETs can also behave in an aggressive manner with a 5-year survival as low as 30% in non-functioning PNETs. Many therapeutic agents have been tested in the treatment of NET including Interferon alfa, streptozocin or temozolomide-based combination chemotherapy with an objective response of 10%\u201330%. Moreover these agents are less effective in patients with advanced carcinoid tumors and their prolonged use is often associated with added toxicity. A number of other signaling pathways have also been implicated in neuroendocrine tumors, which also express platelet-derived growth factor (PDGF), PDGF receptor (PDGFR), insulin-like growth factor-1, insulin-like growth factor receptor, basic fibroblast growth factor, transforming growth factor, epidermal growth factor receptor, and stem-cell factor receptor. \n \nSunitinib malate (SUTENT\u00ae; Pfizer Oncology) is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-\uf061, PDGFR-\uf062, stem-cell factor receptor, glial cell line derived neurotrophic factor receptor and FMS-like tyrosine kinase-3. \nThis review will present data regarding sunitinib progress in PNET, demonstrating its effectiveness and the emerging hope it may provide for such a disease with limited treatment options.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":54929162,"openaccessinfo":{"externalids":{"MAG":"2063219756","ACL":null,"DOI":"10.4137\/CMRO.S7198","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fifty two patients with suspected carpal tunnel syndrome were evaluated electrodiagnostically by using a variety of screening tests. The criteria of normalcy were as follows: distal median motor latency lower than 4.2 ms, distal median sensory latency wrist-to-third finger at 14 cm higher than 3.2 ms for the onset and than 3.8 ms to the peak, median sensory conduction velocity wrist-to-palm at 7 cm higher than 40 m\/s peak-to-peak and difference between median and radial sensory latencies wrist-to-first digit at 11 cm using an intermediate position as site of stimulation and measured peak-to-peak (\"bactrian sign\") higher than 0.4 ms. Other tests such as median-ulnar comparison using finger 4 were considered less reliable based primarily on the frequent association of carpal tunnel syndrome and Guyon canal entrapment. Carpal tunnel syndrome was confirmed in 49 of 52 suspected cases (94.2%) by at least one abnormal screening test. Bilateral involvement was noted in 65.3% of the cases (32 patients). The \"bactrian\" (two-hump camels) sign was the single most sensitive test used, being positive in 83.7% of cases. The second most sensitive test was median SNAP (wrist-to-finger) latency and the third, sensory conduction velocity across the carpal tunnel.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23538590,"openaccessinfo":{"externalids":{"MAG":"2046482230","ACL":null,"DOI":"10.1097\/00002060-198810000-00007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"\"The Bible at Qumran\" puts the Dead Sea Scrolls to use in exploring two principal themes: the text and shape of the \"Bible\" at Qumran and the interpretation of these scriptures in this fascinating Jewish community. Written by leading scholars in the field, these informed studies make an important contribution to our understanding of the biblical text at a pivotal period in history. Contributors: Martin G. Abegg Jr. James E. Bowley Craig A. Evans Peter W. Flint James A. Sanders James M. Scott Eugene Ulrich James C. VanderKam Robert W. Wall Bruce K. Waltke","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":160403760,"openaccessinfo":{"externalids":{"MAG":"616110954","ACL":null,"DOI":"10.2307\/3087539","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"I describe a new technique for improving the sensitivity of the solid-phase \"sandwich\" assay, by using the through-passage receptacle in a novel flow-communication device. The technique allows a large volume of serum to flow through the antibody-coated receptacle repeatedly during the incubation and is thus termed the \"flow-through large-volume incubation\" method. Binding of 125I-labeled hepatitis B surface antigen to its corresponding antibody on a solid-phase by this method was more rapid and persistent than binding by the conventional method. When the method was applied to the first incubation of the sandwich assay, the test for the antigen was rendered four-, eight-, and 32-fold as sensitive as an accepted third-generation test for the antigen, by incubating 5-mL volumes of serum at (a) room temperature for 18 h, (b) 45 degrees C for 8 h, or (c) room temperature for seven days, respectively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26377769,"openaccessinfo":{"externalids":{"MAG":"2254273257","ACL":null,"DOI":"10.1093\/CLINCHEM\/25.1.178","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was carried out to determine the suitability of fecal indicator bacteria to predict human health risks associated with hepatitis A virus in a river in Nigeria, representing a regional situation in comparison with other global aspects. Water samples were collected from River Owena weekly over a period of twelve weeks i.e., July-September, 2017. The concentration of Escherichia coli, fecal coliforms, Salmonella and Shigella were determined by standard microbiological method. The concentration of hepatitis A virus was determined using standard molecular detection technique. Physicochemical properties of the water samples were determined using standard methods. Results showed that the concentration of Escherichia coli in the water samples ranged from 4.11 to 4.35 log10 CFU 100 ml-1 whereas those of fecal coliforms ranged from 4.23 to 4.51 log10 CFU 100 ml-1. Whilst the concentrations of the bacterial indicators correlated positively, there was no significant relationship between the concentration of hepatitis A virus and those of the bacterial indicators in the water samples. The findings from this study suggest that the sanitary quality of surface waters based on bacterial indicators may be inadequate in protecting human health from risks associated with hepatitis A virus.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":132974920,"openaccessinfo":{"externalids":{"MAG":"2926850777","ACL":null,"DOI":"10.12691\/jaem-7-1-2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Art in general can be thought of as a stochastic process. No two drawings or paintings are exactly alike, and cannot be as long as humans are involved. Generative art, the defining of an artwork using an algorithm, can result in very precise duplications of artworks but this is rarely interesting. Art is a human activity and artworks are a means of communication between humans, even in the generative domain. Adding randomness to a generative work makes it seem more human, and often more interesting. How much randomness should there be? What is the context of the random features? Why is randomness interesting? These things will be discussed, along with some ideas on how to use randomness as a tool in creating artworks.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":226753423,"openaccessinfo":{"externalids":{"MAG":"3088494418","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A facile and reversible phase-transfer protocol for luminescent ZnO quantum dots (QDs) between methanol and hexane is presented. Oleylamine together with acetic acid trigger this reversible phase-transfer process, during which the structure and optical properties of the ZnO QDs are well-protected. ZnO QDs with a diameter of approximately 5\u2005nm emit yellow light at 525\u2005nm, while those with a diameter of approximately 4\u2005nm emit green light at 510\u2005nm. The positions of the emission peaks remain unchanged during the presented phase-transfer process. The Pearson's hard and soft (Lewis) acid and base principle, together with the principle that similar substances are more likely to be dissolved by each other, describes the current reversible phase-transfer process. Herein, we circumvent the time-consuming work required to synthesize ZnO QDs in different environments, making it possible to combine the advantages of ZnO QDs dispersed in polar and nonpolar solvents.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6833142,"openaccessinfo":{"externalids":{"MAG":"2126066800","ACL":null,"DOI":"10.1002\/chem.201203236","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The laser damaged threshold (LDT) of potassium dihydrogen phosphate (KDP) crystals grown at different supersaturation points were investigated using a Nd:YAG nanosecond laser. The growth rate was measured by a laser polarization interference system. Combining the step slopes, the dependence of v\u2013(\u03c3) was obtained. It is interesting that the dependence of LDT-(\u03c3) can also be divided into three areas and shows a similar dependence to that of v\u2013(\u03c3). The LDT reduces rapidly at the transition supersaturation area, and has the lowest value at \u03c3 = 0.07. In different supersaturation regions, the micro morphology of the KDP crystals was observed using an atomic force microscope. The nature of the step movement and bunching together of steps may contribute to the dependence of LDT-(\u03c3).","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":104654451,"openaccessinfo":{"externalids":{"MAG":"2898113474","ACL":null,"DOI":"10.1039\/c8ra07207h","PubMedCentral":"9088828","ArXiv":null},"license":"CCBYNC","url":"https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/ra\/c8ra07207h","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract Permutation classes are sets of permutations defined by the absence of certain substructures. In some cases permutation classes can be decomposed as unions of subclasses. We use combinatorial specifications automatically discovered by Combinatorial Exploration: An algorithmic framework for enumeration, Albert et al. 2022, to uniformly generate large random permutations in a permutation class, and apply clustering methods to partition them into interesting subclasses. We seek to automate as much of this process as possible.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":249825551,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2478\/puma-2022-0006","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/sciendo.com\/pdf\/10.2478\/puma-2022-0006","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Chapter One. \nAnthecularin is a new antimalarial sesquiterpene lactone, which was iso-lated from Anthemis auriculata. It originates from Asteraceae, the fami-ly of plants which produce the artimisinin that is known as an antima-larial compound. It possesses inhibitor activity towards PfFabG and PfFabI enzymes, and also shows an antitrypanosmal effect on primary mammalian cells without any toxicity. \nAnthecularin is a minor sesquiterpene with a novel ring system. The stereochemistry of this new sesquiterpene lactone skeleton indicated the existence of fused seven-and six-membered rings. \nHerein our current study is focused on the biomimetic synthesis of anthecularin. Our strategy proposes the formation of this natural prod-uct utilizing an intramolecular Diels-Alder cycloaddition in a new biomi-metic pathway inspired by the proposed biogenesis route of anthecular-in. Starting from 2-methacrolein as a readily available material to pro-duce ester through Wittig-Horner reaction, followed by reduction of the ester product. Subsequently the primary alcohol undergoes nucleophilic substitution yielded the propargyl ether, the precursor for the carbocy-clization reaction, which will be followed by oxidation of the cyclic lac-tone after protection of the alcohol. But the carbocyclization reaction did not work, and this prompted us to propose another retrosynthesis route. \nChapter Two. \nThis chapter describes the development of a novel route to access the total synthesis of spirocyclic tetrahydroindolizines, featuring a 1,2-dihydropyridine, that may finally be transformed into alkaloid-like indolizidines. The key reaction in this innovative approach is the 1,3-dipolar cycloaddition between pyridinium stabilised ylides and different electrophilic alkenes to generate spirocyclic dihydropyridines as single diastereoisomers with excellent diastereoselectivity. \nThe Introduction introduces related indolizidine natural products such as rhynchophylline, isorhynchophylline, mitraphylline and isometraphylline. This section also reports on development in the field of 1,3-dipolar cycloaddition chemistry, with particular emphasis on the cycloaddition chemistry of pyridinium and related ylides. \nThe Result and Discussion section is divided into three parts. Part I describes model study towards the synthesis of butenolides. Part II describes generation of pyridinium ylides from pyridinium salts in the presence of a variety of dipolarophiles. Further to this, the synthesis of a variety of dipolarophiles is also described. These were then employed in 1,3-dipolar cycloadditions, to achieve tetrahydroindolizines in good yield with excellent diastereoselectivity. The final part describes modification of the 1,2-dihydropyridine ring. Ultimately, expansion of the scope of the reduction reactions is described and opportunities for further developments are discussed. \nThe Experimental part describes all procedures by which compounds disclosed in this thesis were synthesised. Furthermore, full spectroscopic data and characterisation is provided.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":103786691,"openaccessinfo":{"externalids":{"MAG":"2766052146","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents an efficient method for calculating the similarity between 2D closed shape contours. The proposed algorithm is invariant to translation, scale change and rotation. It can be used for database retrieval or for detecting regions with a particular shape in video sequences. The proposed algorithm is suitable for real-time applications. In the first stage of the algorithm, an ordered sequence of contour points approximating the shapes is extracted from the input binary images. The contours are translation and scale-size normalized, and small sets of the most likely starting points for both shapes are extracted. In the second stage, the starting points from both shapes are assigned into pairs and rotation alignment is performed. The dissimilarity measure is based on the geometrical distances between corresponding contour points. A fast sub-optimal method for solving the correspondence problem between contour points from two shapes is proposed. The dissimilarity measure is calculated for each pair of starting points. The lowest dissimilarity is taken as the final dissimilarity measure between two shapes. Three different experiments are carried out using the proposed approach: letter recognition using a web camera, our own simulation of Part B of the MPEG-7 core experiment \"CE-Shape1\" and detection of characters in cartoon video sequences. Results indicate that the proposed dissimilarity measure is aligned with human intuition.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1100556,"openaccessinfo":{"externalids":{"MAG":"2104933556","ACL":null,"DOI":"10.1145\/973264.973287","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/doras.dcu.ie\/396\/1\/mir_2003.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Platelets are known to be central regulators of haemostasis, inflammation and immune response. Formed by megakaryocytes in the bone marrow and the lungs, platelets express a broad range of adhesion receptors and release cytokines and platelet microparticles which enable them to interact with both immune cells and pathogens. In bacterial and viral infections, thrombophilia and thrombocytopenia are commonly seen symptoms, indicating the close relationship between haemostasis and immune defence. Indeed, platelets contribute both directly and via immune mediation to pathogen clearance. In sterile inflammation, a pathogen-free process which is often triggered by cell necrosis and autoimmune reactions, platelets are also of central importance. Recently, platelet inflammasome has been extensively studied in this context. Both sterile inflammation and infection are affected by the interactions of platelets and innate immunity, notably the complement system. Although the general elements of this interplay have been known for long, more and more insights into disease-specific mechanisms could be gained recently. This review gives an outline of the current findings in the field of platelet\u2013immune cell interactions and points out possible implications for clinical therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52824391,"openaccessinfo":{"externalids":{"MAG":"2900776049","ACL":null,"DOI":"10.1055\/s-0038-1669450","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1669450.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":": Tabebuia serratifolia is an arboreal species, widely distributed in Brazil, with high eco-nomical and ornamental value. Its propagation is made by seeds dispersion and little is known about the methodology to evaluate its seeds physiological quality. Therefore, this work studied types of ap-propriate substrate and temperatures for running the germination test of Tabebuia serratifolia under laboratory condition. The germination test was carried out using two seed lots (harvest of 1998 and 1999), two types of substrates(blotter and sand) under different temperature regimes (ranging from 15 to 35 o C on a termogradient table, and an oscillating regime 20-30 o C in a BOD incubator) with photo-period of 12 hours. The evaluation was made daily and the results expressed as percentage and index of germination speed.The results showed that the seed germination was higher at temperatures in the 25 to 35 o C range, being quicker at 30 o C. Under temperature oscillating from 20 to 30 o C, germination was not favored. Regarding to the substrate both sand and blotter were promising to be used in the germination test in the optimal range of temperature.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":88464347,"openaccessinfo":{"externalids":{"MAG":"2361630291","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The last years of the reign of Philip III and the beginning of that of Philip IV were characterized by an expansion of the fronts of conflict: from the Mediterranean, to the northern part of the Italian peninsula, the heart of Europe. The military engagement, especially on imperial territory and Flanders (since 1621), demanded an increase in the tax burden in all domains of the Monarchy. In Sicily, to encounter the demands of \"socorros\" from Madrid, it became necessary to revise and streamline the entire administrative apparatus \/ tax and identify new taxations forms. This study aims to offer a reflection on the measures taken between 1618 and 1621 in order to rearrange the writing accounting of the Kingdom, and the analyses of the expedients agreed by the Viceroy, the Tribunale del Real Patrimonio and Council of State and Council of Italy, in order to meet the demand of one million scudi in support of the troops engaged in the Thirty Years' War.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":163109543,"openaccessinfo":{"externalids":{"MAG":"2256628017","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wistar female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT: 5 and 20 U\/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35135104,"openaccessinfo":{"externalids":{"MAG":"2318452431","ACL":null,"DOI":"10.1248\/BPB.16.325","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A number of authors have described the zoeal development of the Chinese mitten crab, Eriocheir sinensis H. Milne Edwards, 1853, while some of these studies only recognised 5 zoeal stages, two of them described six. The present study re-examined the zoeal stages of E. sinensis from laboratory-reared material using confocal laser scanning microscopy and visualised the images using the open-source software programmes ImageJ and Drishti. From these images 6 zoeal stages were re-described and compared with all previous larval descriptions of the Chinese mitten crab. Comments on the variation of some setal characters are also described in zoeal stages IV-VI.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":54151995,"openaccessinfo":{"externalids":{"MAG":"2898733844","ACL":null,"DOI":"10.11646\/zootaxa.4507.1.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Platelet basic protein (PBP) (94 residues) is naturally processed via N-terminal cleavage to yield connective tissue activating peptide-III (85 residues), beta-thromboglobulin (81 residues), and neutrophil activating peptide-2 (70 residues). Chemical cross-linking and gel filtration data indicate that each homolog can form dimers and tetramers. Subunit association equilibria for dimer (KD) and tetramer (KT) formation have been derived for each species from 1H NMR (600 MHz) spectral analysis of slowly exchanging (NMR time scale) monomer- dimer-tetramer aggregation state populations. In general, raising the pH from about pH 3.5 to pH 6 increases KD by two to three orders in magnitude and decreases KT by some 50-fold. Ionic strength effects also suggest that intersubunit electrostatic interactions are critical to subunit association. Subunit stabilization can be ranked proportional to N-terminal chain length: platelet basic protein > connective tissue activating peptide-III > beta-thromboglobulin > neutrophil activating peptide-2. Under more physiologic conditions, PBP family monomers are favored at normal cytokine protein concentrations and may form the biologically active state. CD and NMR data indicate conservation of alpha-helix and anti-parallel beta-sheet structure among PBP-related species and support the idea that the extended N terminus folds over and masks the neutrophil activation domain and is part of the intersubunit binding domain.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2565561,"openaccessinfo":{"externalids":{"MAG":"1608826224","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The aim of the study is to compare the level of innovation of companies introducing innovations with consumer participation with that of other innovative providers of health tourism services. The following hypothesis was formulated: Companies benefiting from the participation of consumers in the process of innovation represent a higher level of innovativeness than other innovative providers of health tourism services. The following methods were used: a comparative analysis, a questionnaire (CAWI and PAPI), a standardized interview, and the ranking method. 461 providers of health tourism services participated in the research. The value and implications of the paper for the economic sciences contribute to the development of innovation theory. The hypothesis has been positively verified. The research shows a much higher level of innovation in companies cooperating with consumers (patients) than that of other respondents.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54695655,"openaccessinfo":{"externalids":{"MAG":"2580150010","ACL":null,"DOI":"10.1515\/emj-2016-0030","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1515\/emj-2016-0030","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to investigate the effects of hearing loss and adverse listening conditions on the conversational patterns of seniors. A second goal was to determine what measures best describe these conversational patterns. Results were compared to those of a case study of a hard-of-hearing senior presented by Pichora-Fuller & Johnson (submitted). One normal-hearing and one hearing-impaired senior were selected for this study. Each subject participated in two conversations, one in an advantageous condition and one in an adverse, noisy listening condition. Participants were interviewed about their ability to understand the conversations. Further measures of comprehension included free and recognition recall tasks, a conversational fluency rating, and a detailed discourse analysis based on a transcript of the conversations. Of all the comprehension measures used, the recognition task appeared to be the most sensitive indicator of perceptual diff iculty and comprehension of conversational detail. Free recall results were a good measure of relative memory for detail and gist across the different signal-to-noise ratio conditions. Results of the discourse analysis provided quantitative evidence that was able to support or contradict the comprehension diff icult ies indicated on the conversational fluency ratings. The discourse analysis procedure was too time-intensive to bea viable clinical tool.' However, some aspects of the i i i analysis, including production of new content, overt repair requests, and subtopic management, could be singled out as particularly helpful in identifying comprehension problems, indicating that a more selective analysis may suffice for clinical purposes. No marked differences in comprehension between the hearing-impaired and normal-hearing senior were observed for the conversations in advantageous listening conditions. In the adverse listening conditions, the normal-hearing participant reported greater effort, but his comprehension did not appear to be significantly affected. Results were consistent with the Pichora-Fuller & Johnson (submitted) study in that both hard-of-hearing seniors showed reduced comprehension of the conversations in adverse listening conditions on all of the comprehension measures. However, individual variables appeared to have a significant effect on conversational behaviour. In particular, the subject of the Pichora-Fuller & Johnson (submitted) study tended to conceal her hearing problems by feigning understanding, while the hearing-impaired senior of the present study appeared to initiate repairs whenever they were needed. It was evident from the results presented here that individual baseline information is essential to the assessment of conversational behaviour and comprehension difficulties. iv TABLE OF CONTENTS","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":147330410,"openaccessinfo":{"externalids":{"MAG":"2310208615","ACL":null,"DOI":"10.14288\/1.0099176","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study suggests using a user-initiated detecting and data gathering from power-limited and even passive wireless devices, such as passive RFID tags, wireless sensor networks (WSNs), and Internet of Things (IoT) devices, that either power limitation or poor cellular coverage prevents them from communicating directly with wireless networks. While previous studies focused on sensors that continuously transmit their data, the focus of this study is on passive devices. The key idea is that instead of receiving the data transmitted by the sensor nodes, an external device (a reader), such as an unnamed aerial vehicle (UAV), or a smartphone is used to detect IoT devices and read the data stored in the sensor nodes, and then to deliver it to the cloud, in which it is stored and processed. While previous studies on UAV-aided data collection from WSNs focused on the UAV path planning, the focus of this study is on the rate at which the passive sensor nodes should be polled. That is, to find the minimal monitoring rate that still guarantees accurate and reliable data collection. The proposed scheme enables us to deploy wireless sensor networks over a large geographic area (e.g., for agricultural applications), in which the cellular coverage is very poor if any. Furthermore, the usage of initiated data collection can enable the deployment of passive WSNs. Thus, can significantly reduce both the operational cost, as well as the deployment cost, of the WSN.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":236251502,"openaccessinfo":{"externalids":{"MAG":"3171364149","ACL":null,"DOI":"10.21203\/RS.3.RS-488167\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: COVID-19, caused by the coronavirus, was declared a global pandemic by the WHO on March 11, 2020. The COVID-19 pandemic hit India, similar to the world, reporting its first case in March 2020. After the first wave, the second wave in India started on March 2021. The impact of the second wave was huge on all tertiary care centers, especially psychiatric care centers, compared to the first wave of COVID-19. Aim: The aim of this study is to study the impact of COVID-19 on psychiatric patients at a tertiary psychiatric hospital in Telangana state of South India. Methodology: A retrospective chart review of all patients who got infected with COVID-19 during the second wave was done. We screened all the inpatient cases who were under admission during the second wave. For the study, a semi-structured intake pro forma was used. Sociodemographic variables, clinical variables, treatment variables, and outcomes of COVID-19-infected psychiatric patients were studied. Results: The current article compiles the management of the COVID-19 outbreak in the Institute of Mental Health in inpatient care and the challenges and experiences during the management of psychiatric inpatients with COVID-19 in a tertiary care center in Telangana.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":249222591,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4103\/tjp.tjp_6_22","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/tjp.tjp_6_22","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Spurious correlations are a threat to the trustworthiness of natural language processing systems, motivating research into methods for identifying and eliminating them. However, addressing the problem of spurious correlations requires more clarity on what they are and how they arise in language data. Gardner et al (2021) argue that the compositional nature of language implies that all correlations between labels and individual \"input features\" are spurious. This paper analyzes this proposal in the context of a toy example, demonstrating three distinct conditions that can give rise to feature-label correlations in a simple PCFG. Linking the toy example to a structured causal model shows that (1) feature-label correlations can arise even when the label is invariant to interventions on the feature, and (2) feature-label correlations may be absent even when the label is sensitive to interventions on the feature. Because input features will be individually correlated with labels in all but very rare circumstances, domain knowledge must be applied to identify spurious correlations that pose genuine robustness threats.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248512446,"openaccessinfo":{"externalids":{"MAG":null,"ACL":"2022.naacl-main.321","DOI":"10.18653\/v1\/2022.naacl-main.321","PubMedCentral":null,"ArXiv":"2204.04487"},"license":"CCBY","url":"https:\/\/aclanthology.org\/2022.naacl-main.321.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Meat 4.0 refers to the application the fourth industrial revolution (Industry 4.0) technologies in the meat sector. Industry 4.0 components, such as robotics, Internet of Things, Big Data, augmented reality, cybersecurity, and blockchain, have recently transformed many industrial and manufacturing sectors, including agri-food sectors, such as the meat industry. The need for digitalised and automated solutions throughout the whole food supply chain has increased remarkably during the COVID-19 pandemic. This review will introduce the concept of Meat 4.0, highlight its main enablers, and provide an updated overview of recent developments and applications of Industry 4.0 innovations and advanced techniques in digital transformation and process automation of the meat industry. A particular focus will be put on the role of Meat 4.0 enablers in meat processing, preservation and analyses of quality, safety and authenticity. Our literature review shows that Industry 4.0 has significant potential to improve the way meat is processed, preserved, and analysed, reduce food waste and loss, develop safe meat products of high quality, and prevent meat fraud. Despite the current challenges, growing literature shows that the meat sector can be highly automated using smart technologies, such as robots and smart sensors based on spectroscopy and imaging technology.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":250469254,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/app12146986","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2076-3417\/12\/14\/6986\/pdf?version=1657615092","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Using the translational energy-gain spectroscopy technique, we have measured the energy-gain spectra and absolute total cross sections for single-electron capture in collisions of O3+ ions with He, H2O and CO2 at impact energies between 0.3 and 1.2 keV and scattering angles between 0\u00b0 and 6\u00b0. At the lowest collision energy, 300 eV, the energy-gain spectrum for O3+ - He collisions indicates that single-electron capture into the 2s2p3 3P state of the product O2+ is the dominant reaction channel observed with smaller contributions from capture into the 2s2p3 1D, 3S and 1P states. For O3+ - H2O collisions, the dominant peak correlates with capture into the 2p3p state of O2+, with a significant contribution involving capture into the 2p3s state. In O3+ - CO2 collisions, the dominant reaction channel is due to capture into the 2p3s state of O2+, with contributions from capture into the 2p3p state. The measured cross sections are compared with the available measurements and theoretical results based on the multi-channel Landau-Zener (MCLZ) model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250671521,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1742-6596\/58\/1\/040","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/58\/1\/040","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The formula for the intensity of surface second-harmonic generation circular dichroism (SHG-CD) in helical molecular films is presented. The influence of the pitch and radius of helical molecules on the surface SHG-CD intensity is numerically analysed. The existence of a peak in the curves of the surface SHG-CD intensity versus the pitch and radius is predicted. The relation between the pitch and radius for different azimuthal angles is also discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250845906,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0256-307X\/18\/3\/324","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0Over the past 15 years, software for processing interferometric synthetic aperture radar (InSAR) data into maps of surface deformation has been developed and refined. The InSAR technique is commonly used to investigate deformation associated with earthquakes, volcanoes, withdrawal of crustal fluids, and coherent ice motions [Massonnet and Feigl, 1998]. The software, called Generic Mapping Tools Synthetic Aperture Radar (GMTSAR), is an open-source (GNU General Public License) InSAR processing system designed for users familiar with Generic Mapping Tools (GMT) [Wessel and Smith, 1998]. The GMTSAR code is written in the C programing language and will run on any UNIX\u00ae computer. It requires installation of GMT and Network Common Data Format (NetCDF) and supports several fast Fourier transform libraries.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128908870,"openaccessinfo":{"externalids":{"MAG":"2059496600","ACL":null,"DOI":"10.1029\/2011EO280002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PurposeBlockchain technology (BCT) has multiple benefits across industries in varied contexts, but limited organizations have adopted such disruptive innovative technologies in the healthcare industry in India. The research on advancing the understanding of blockchain adoption (BCA) determinants in India's healthcare industry is limited. Thus, the study aims to identify the BCA determinants in the healthcare sector in India. Further, the impact of BCA was examined on organizational performance (OP).Design\/methodology\/approachThe study utilizes Technology, Organization, and Environment (TOE) framework to investigate the determinants of BCA in the healthcare sector in India. The data were gathered using a seven-point Likert seven-point ranging from \"strongly agree\" to \"strongly disagree\" from 272 respondents working in the healthcare industry in India. The relationship within the framework was investigated using structural equation modeling.FindingsThe results demonstrate the positive impact of top management support, organizational size, organizational readiness, competitive pressure and government support on BCA in the healthcare sector. On the other hand, compatibility, security and privacy issues do not affect BCA. The results emphasize and validate blockchain's importance in improving OP in the healthcare sector. Further, the results indicate that non-technological factors are paramount to improving BCA within the healthcare sector. Organizations should invest in employee training and development to ensure their staff have the necessary knowledge and skills to effectively manage BCT.Research limitations\/implicationsThe model was developed for BCA in the healthcare sector in the Indian context; however, the model applies to other countries with the same business environment. Hence, the model can be further examined in diverse countries to generalize the findings.Practical implicationsThe study offers valuable insights into the factors that influence BCA and OP in the healthcare sector. The results of this research can be used to inform policy decisions and guide practitioners toward promoting and facilitating the use of BCT in healthcare organizations.Originality\/valueTo the best of the author's knowledge, the present study is the first of its kind to examine the TOE framework in BCA within the healthcare sector and its implications on OP.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":260394638,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1108\/ajb-12-2022-0206","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Narcissism is related to income and risk-taking behavior, but previous studies have computed only pairwise associations and have used only domain-specific risk-taking measures. We jointly investigated narcissistic admiration and rivalry, income, and general risk attitude. Using a representative sample from the German population (N = 14,473), we contrasted a model assuming that risk attitude and narcissistic admiration and rivalry share variance when predicting income and a model with additive effects of narcissism and risk attitude. We found stronger effects of admiration on risk attitude and income than of rivalry and no evidence that risk attitude and narcissism share variance when predicting income. Contrary to previous studies, we found that an individual's income was independent of their risk attitude. In exploratory analyses (Response Surface Analysis, Level-and-Difference-Approach), we found that the relative strength of admiration compared with rivalry positively predicted risk attitude and income. Taken together, our findings are consistent with the hierarchical model of grandiose narcissism.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":239462291,"openaccessinfo":{"externalids":{"MAG":"3207131697","ACL":null,"DOI":"10.5964\/ps.7293","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.5964\/ps.7293","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objectives: To compare implantation rates, clinical pregnancy rates and live birth rates associated with natural and hormone replacement therapy (HRT) methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles. Methods: The results of 108 natural cycles and 224 HRT cycles of FET transfers performed in a private in vitro fertilization (IVF) center between June 2013 and August 2015 were retrospectively compared with respect to implantation rate, clinical pregnancy rate, and live birth rate. Results: A total of 144 embryos were transferred in 108 natural cycles and 357 embryos were transferred in 224 HRT cycles. No statistically significant differences were found in the implantation rate (p=0.796), clinical pregnancy rate per cycle (p=0.900), clinical pregnancy rate per transferred embryo (p=0.283), live birth rate per cycle (p=0.821), or live birth rate per transferred embryo (p=0.481) between the 2 groups. Conclusion: This study showed no difference between the implantation rate, clinical pregnancy rate or live birth rate between the natural cycle group and HRT cycle group. These results may provide clinicians with more freedom to individualize patient treatment, particularly with respect to the selection of the endometrial preparation method, if these results are supported by large randomized controlled studies in the future.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53245057,"openaccessinfo":{"externalids":{"MAG":"2900356579","ACL":null,"DOI":"10.15537\/smj.2018.11.23299","PubMedCentral":"6274666","ArXiv":null},"license":null,"url":"https:\/\/smj.org.sa\/content\/smj\/39\/11\/1102.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A pair of uncommon fused multicyclic polyketides with a two- spiro-carbon skeleton, (\u00b1)-isoepicolactone, (\u00b1)-1, and one new isobenzofuranone monomer (4), together with four other known biosynthetically related compounds were isolated from the fermentation of an endophytic fungus, Epicoccum nigrum SCNU-F0002, which was isolated from the fresh fruit of the mangrove plant Acanthus ilicifolius L. Comprehensive spectroscopic analysis, X-ray crystallography, together with calculated ECD, were employed to define the structures. The antibacterial and COX-2 inhibitory activities of the compounds (1\u20136) were evaluated. A possible biogenetic pathway of (\u00b1)-isoepicolactone was confirmed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225446653,"openaccessinfo":{"externalids":{"MAG":"3047582776","ACL":null,"DOI":"10.1039\/d0ra05532h","PubMedCentral":"9055859","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1039\/d0ra05532h","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A new atelomycterine catshark species (Scyliorhinidae: Atelomycterinae), Atelomycterus baliensis sp. nov., is described from eastern Indonesia (Jimbaran Bay, Bali). It differs from other Atelomycterus species in having a higher pectoral-pelvic to pelvic-anal ratio and short claspers with the glans extending over more than half of the clasper length. Most similar to its more widely distributed, sympatric congener A. marmoratus, A. baliensis differs from this species in having lower total and precaudal vertebrae counts, more strongly tricuspid denticles, white spots absent from the body, obvious dark saddles on the back, and less oblique pale tips on its weakly falcate dorsal fins.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":83471579,"openaccessinfo":{"externalids":{"MAG":"1924143273","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cities are fast becoming new territories of violence. The humanitarian consequences of many criminally violent urban settings are comparable to those of more traditional wars, yet despite the intensity of the needs, humanitarian aid to such settings is limited. The way in which humanitarian needs are typically defined, fails to address the problems of these contexts, the suffering they produce and the populations affected. Distinctions between formal armed conflicts, regulated by international humanitarian law, and other violent settings, as well as those between emergency and developmental assistance, can lead to the neglect of populations in distress. It can take a lot of time and effort to access vulnerable communities and implement programmes in urban settings, but experience shows that it is possible to provide humanitarian assistance with a significant focus on the direct and indirect health consequences of violence outside a traditional conflict setting. This paper considers the situation of Port-au-Prince (Haiti), Rio de Janeiro (Brazil) and Guatemala City (Guatemala).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12922413,"openaccessinfo":{"externalids":{"MAG":"2137914038","ACL":null,"DOI":"10.1111\/j.1467-7717.2010.01178.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/fieldresearch.msf.org\/bitstream\/10144\/128594\/1\/Between%20war%20and%20peace%20-%20Disasters%2034-04%202010-10.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We discuss the production of \u03b7c(2S) through the process e+e\u2212 \u2192 \u03b3\u03b7c(2S), where the leading contribution originates from 1-loop electroweak corrections. Adopting some reasonable light-cone distribution amplitudes, we analyze the cross section of this process. As the electron-positron center of mass energy \u221as = 3770 MeV, the typical production cross section of this process is about 1 fb.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250903256,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1674-1137\/37\/7\/073102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Foliage-spraying selenite solution is an effective measure to enhance selenium (Se) concentration in wheat grains. However, how pH, temperature, light intensity, and leaf position affects selenite absorption in wheat leaf blades is not fully understood. In this study, the effects of pH, temperature, light intensity, and leaf position on selenite absorption in wheat leaf blades were investigated. The results indicated that the selenite absorption rate dramatically decreased with increasing pH. Further study revealed that aquaporin inhibitors such as HgCl2 and AgNO3 strongly inhibited selenite absorption at pH 3.0. Light and higher temperatures significantly promoted selenite absorption. Newly expanded leaf blades had higher rates of selenite absorption than younger and older leaf blades. Thus, higher rates of selenite absorption in leaf blades should attribute to the entrance of selenite into mesophyll cells via aquaporins in the form of H2SeO3 at low pH values. Foliage-spraying selenite solution on upper leaf blades at lower pH values benefited to increase the selenite absorption rate in wheat leaf blades.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":221695492,"openaccessinfo":{"externalids":{"MAG":"3053541154","ACL":null,"DOI":"10.17221\/337\/2020-pse","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.agriculturejournals.cz\/publicFiles\/337_2020-PSE.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This research is motivated by the learning outcomes of students in science learning, there are still many who have not reached the KKM, this is because the users of the learning model applied by the teacher are still not optimal and the learning model used is not varied so that students feel bored and passive in class. This study aims to determine the effect of the Contectual Teaching and Learning (CTL) Model on Science Learning Outcomes in Class V at SD NEGERI 37\/II Pasar Lubuk Landai, Bungo Regency. \nThis type of research is Pre Experiment Design research. With a quantitative approach and the form of design using a Quasi-Experimental Non-Equivalent Group Pre-test Post-test Design method. The subjects of this study were fifth grade students of SD Negeri 37\/II Pasar Lubuk Landai. The sampling of this research used the probanility Sampling technique, which consisted of 18 students. The data collection technique was done by using test and non-test techniques. The data collection tool is in the form of multiple choice questions, totaling 20 items for pre-test and post-test through validation test. And reability test. Data were analyzed using the Normality Test and Hypothesis Testing\/t-test processed using SPSS 22. \nThe results of the calculation of the hypothesis test sig","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":239690065,"openaccessinfo":{"externalids":{"MAG":"3198188273","ACL":null,"DOI":"10.31004\/INNOVATIVE.V1I2.2069","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In a number of countries one observes a steady decline in defined benefits pensions schemes, public or private, funded or unfunded, and a simultaneous expansion of defined contributions plans. One of the consequences of this trend is to deprive individuals at the time of their retirement from the benefit of collective annuitization. Collective annuities can be distinguished from individual ones in two ways. First, they tend to be cheaper because of their scale and because of inefficiencies in private annuity markets. Second they redistribute resources from short-lived to long-lived individuals. Our paper studies the role of collective annuities. Both their redistributive incidence and efficiency aspects are accounted for. We assume that lifetime is uncertain and that there is a positive correlation between longevity and earnings. Collective annuitization (in part or in total) can be imposed on private savings or it can be \"bundled\" with a redistributive pension scheme. We show that the case for applying collective annuitization to private savings is weak. The case is stronger when collective annuities are associated with redistributive pensions. However, even in that case, collective annuitization may mitigate the redistributive benefits associated with the pension system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":17080110,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A field model study was carried out in Klang area of Selengor Dharul Ehsan, Malaysia to observe the settlement of stabilized group peat columns. Peat soil exhibits very low bearing capacity and this soil is not suitable for constructing embankment, highway, building or any other load bearing engineering structure. Large areas of land all over the world are covered by problematic peat soils. The growing demand of space to accommodate new buildings and infrastructures has increased the utilization of soft ground such as peatland. Two sets of test group columns were constructed to stabilize tropical peat by in-situ soil-column with mixing auger and Prebored-premixed method using high setting PFA cement, calcium chloride and siliceous sand as binders. Static load test was performed to observe the settlement of group columns after 28 days of curing time. Computer modelling using PLAXIS software was conducted to compare the load vs. settlement data of group columns. From this study 13.5 mm settlement was observed for the group columns installed by hand mixing and 17.5 mm settlement was found for the mixing auger method. This is due to the fact that proper mixing plays an important role for the achievement of high load carrying capacity of stabilized column.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129652084,"openaccessinfo":{"externalids":{"MAG":"1891281049","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The biological mode of action of platencin, a poten tial lead molecule for a new class of antibiotics, is detailed. Furthe rmore, enantiopure syntheses of several platencin derivatives are described, of whi ch the core structure can be accessed in two exceedingly simple steps from commercially available starting materials. Furthermore, the antibiotic properties o f the derivatives was evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":97773265,"openaccessinfo":{"externalids":{"MAG":"2183559103","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction and Objectives: The objective of this study was to conduct a review from the literature of the emergence of antimicrobial resistance, the spread of bacteria, their mutations, and policy strategies for the prevention and control of bacterial infections in Europe. \nMaterials and methods: A bibliographic survey was conducted for 2001 to 2016 on the Medline, Lilacs, Scielo, and Google Scholar databases; WHO reports-World Health Organization, ECDC - European Center for Disease Prevention and Control; SNS-National Health Service-Portuguese Republic and basic technical literature books. Searches were conducted in the Portuguese and English language. \nResults: Resistance to antibiotics has been a worldwide public health problem. The European continent has suffered from the spread of multi-drug resistant bacteria. The literature indicates that antimicrobial resistance has increased significantly and that several factors are responsible for this increased resistance, such as the indiscriminate use of antibiotics in both animal food production and human health care, and that the agents of greatest epidemiological significance in Europe are methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Enterobacteriaceae producing ESBLs, Acinetobacter spp and Pseudomonas spp. \nConclusion: Proper and rational use of antibiotics is of the utmost importance at present to avoid an epidemic of bacterial infections. Controlling the spread of resistant bacteria depends not only on correct therapeutic use, but also on basic measures of extreme importance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55513616,"openaccessinfo":{"externalids":{"MAG":"2606310758","ACL":null,"DOI":"10.4172\/2155-6121.1000250","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4172\/2155-6121.1000250","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The sea squirt Halocynthia roretzi is an important marine food resource species that is found in the waters around Korea. We describe the isolation and characterization of 13 new polymorphic microsatellite loci in 96 sea squirt samples that were collected from the marine environment of Samcheok on the east coast of Korea. The number of alleles that were observed for each locus ranged from six to 32, and the value of expected and observed heterozygosities was 0.504\u20130.922 and 0.396\u20130.813, respectively. These markers will be useful tools for future population studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33245038,"openaccessinfo":{"externalids":{"MAG":"1913091027","ACL":null,"DOI":"10.1111\/j.1755-0998.2008.02499.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study examined the effectiveness of two factors in second language vocabulary teaching: (1) presence or absence of a text; and (2) use of a variety of explanation types. The study's context was three 9th grade and one 10th grade class of English-as-a-Second-Language students in Hong Kong. All classes were taught by different teachers. Their classroom techniques for vocabulary instruction were videotaped and identified as nonverbal (use of objects, use of blackboard drawings, use of 1.ictures, demonstrations, use of gestures) or verbal (use of synonyms, paraphrasing, exemplification, dictionary definition, use of affixes and word roots, first-language explanation, solicitation of first-language explanation from students). Each of the four classes was then given a different treatment for instruction of 10 vocabulary items: use of a text and multi-type explanations; text and single type of explanation; multi-ty1.1 explanations without use of a text; and single explanation type without text. Comparison of pretest and posttest performance suggests that use of text is effective in helping learners abstract word meaning, but it was not clear whether single or multiple explanation types were more effective. (MEE) *********************************************************************** Ic Reproductions supplied by EDRS are the best that can be made IC from the original document. Ic *********************************************************************** THE VARIETY AND EFFECTIVENESS OF STRATEGIES EMPLOYED IN VOCABULARY EXPLANATIONS IN EFL CLASSROOMS IN HONG KONG","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":54734852,"openaccessinfo":{"externalids":{"MAG":"277354751","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Executive Summary The CIT Instructional Technology Showcase was held on April 11, 2003 in various rooms in Duke's Perkins Library. This event featured 14 presentations by 45 faculty and staff discussing projects in different subject areas and using a variety of technologies. The program included talks by faculty, staff, and students, a keynote address by a nationally known speaker Franziska Frey of the Rochester Institute of Technology, a poster session, and four workshops. The CIT's goals were to provide recognition for faculty whose projects the CIT has funded, enhance the CIT's presence on campus, motivate new faculty to get involved with instructional technology and inform the Duke community about services offered by the CIT. The intended audience was Duke faculty, technology staff and graduate student instructors. Through the IT Showcase, the CIT hoped to reach a wide variety of people with different levels of experience in instructional technology. Results from surveys distributed at the Showcase and during the week thereafter indicate the Showcase was successful in addressing the goals described above.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":107359274,"openaccessinfo":{"externalids":{"MAG":"137535422","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The application of gas chromatography\/Fourier transform infrared (GC\/FT-IR) data to regulatory decisions requires, among other things, the availability of validated analytical protocols. Such protocols are necessary for the generation of reliable analytical data. A GC\/FT-IR protocol is described which is applicable to the determination of semivolatile organic compounds in wastewater, soils, sediments, and solid wastes. The protocol is designed for the high-throughput automated analysis of multicomponent environmental and hazardous waste extracts. Wastewater analysis for semivolatile organic compounds is based upon the extraction of 1 L of sample with methylene chloride and the concentration of the extract to 1 mL. The analysis of the semivolatile fraction derived from solid waste analysis is based upon the extraction of 50 grams of sample and concentration of the sample extract to 1.0 mL. A gel permeation cleanup option is included to further purify those extracts which cannot be concentrated to the specified final volume. With the use of capillary GC\/FT-IR techniques, wastewater identification limits of 150 to 400 ppb can be achieved with this method, while the corresponding identification limits for solid samples are 3 to 88 ppm. Automated packed-column GC\/FT-IR identification limits are approximately a factor of five higher than the corresponding capillary GC\/FT-IR values. The most frequent obstacle to the achievement of these identification limits is expected to be the presence of large quantities of interfering high-boiling coextractants. These coextractants would raise the identification limits by preventing the concentration of extracts to the desired final volume, thereby necessitating gel permeation cleanup, and\/or by decreasing the spectral signal-to-noise of GC-volatile analytes by raising the spectral background intensity.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2015-11":1,"2015-18":1,"unknown":2}},"corpusid":95107294,"openaccessinfo":{"externalids":{"MAG":"2041835652","ACL":null,"DOI":"10.1366\/0003702854249952","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Political cartoons are a ubiquitous form of satire which assists the public to interpret political life. This study examined the tone and content of 107 political, satirical cartoon images published in mainstream Australian newspapers in 2005 and 2006. The cartoons illustrated the sweeping reforms of the industrial relations system at a turbulent time in Australia's political history. We investigate two dimensions of a sample of widely published cartoons\u2014tone and content\u2014using an established typology. We find that the images were conveyed in a moderate tone in that they were more about poking fun at and questioning authority and power, rather than simply describing the issues on one hand, or demonstrating any revolutionary fervour on the other. The cartoons' content represented many of the concerns and issues being voiced by employer groups, government, opposition, unions and the media at the time. The images were an important part of the wider political discourse and potentially a mechanism through which industrial relations was placed squarely in the minds of working Australians.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":21666883,"openaccessinfo":{"externalids":{"MAG":"2154575879","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rare type of silicate inclusions found in the Elga iron meteorite (group IIE) has a very specific mineral composition and shows silicate (\u224890%)\u2013natrophosphate (\u224810%) liquid immiscibility due to meniscus-like isolation of Na-Ca-Mg-Fe phosphates. The 3 mm wide immiscible inclusion has been first studied in detail using optical microscopy, scanning electron microscopy, electron microprobe analysis and Raman spectroscopy. The silicate part of the inclusion contains fine-grained quartz-feldspar aggregate and mafic minerals. The relationships of feldspars indicate solid decay of initially homogenous K-Na-feldspar into albite and K-feldspar with decreasing of temperature. Some mafic minerals in the silicate part are exotic in composition: the dominant phase is an obertiite-subgroup oxyamphibole (amphibole supergroup), varying from ferri-obertiite NaNa2Mg3Fe3+Ti[Si8O22]O2 to hypothetical NaNa2Mg3Fe2+0.5Ti1.5[Si8O22]O2; minor phases are the aenigmatite-subgroup mineral (sapphirine supergroup) with composition close to median value of the Na2Fe2+5TiSi6O18O2-Na2Mg5TiSi6O18O2 join, orthopyroxene (enstatite), clinopyroxene of the diopside Ca(Mg,Fe)Si2O6\u2013kosmochlor NaCrSi2O6-Na(Mg,Fe)0.5Ti0.5Si2O6 series and chromite. The alteration phases are represented by Fe-dominant chlorite, goethite and hydrated Na2O-rich (2.3\u20133.3 wt.%) Fe-phosphate close to vivianite. Natrophosphate part consists of aggregate of three orthophosphates (brianite, czochralskiite, mari\u0107ite) and minor Na-Cr-Ti-clinopyroxene, pentlandite, rarely taenite. Czochralskiite Na4Ca3Mg(PO4)4 is rich in FeO (2.3\u20135.1 wt.%) and MnO (0.4\u20131.5 wt.%). Brianite Na2CaMg(PO4)2 contains FeO (3.0\u20134.3 wt.%) and MnO (0.3\u20130.7 wt.%) and mari\u0107ite NaFe(PO4) bears MnO (5.5\u20136.2 wt.%), MgO (5.3\u20136.2 wt.%) and CaO (0.5\u20131.5 wt.%). The contact between immiscible parts is decorated by enstatite zone in the silicate part and diopside\u2013kosmochlor clinopyroxene zone in the natrophosphate ones. The mineralogy of the studied immiscible inclusion outlines three potentially new mineral species, which were first identified in meteorites: obertiite\u2013related oxyamphibole NaNa2Mg3Fe2+0.5Ti1.5[Si8O22]O2, Mg-analog of aenigmatite Na2Mg5TiSi6O18O2 and Na-Ti-rich clinopyroxene Na(Mg,Fe)0.5Ti0.5Si2O6.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":219415939,"openaccessinfo":{"externalids":{"MAG":"3024135307","ACL":null,"DOI":"10.3390\/min10050437","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2075-163X\/10\/5\/437\/pdf?version=1590656825","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Four nulliparous, pet, merino ewes from the same property were evaluated at The Animal Hospital at Murdoch University, Western Australia, over a one-year period. The ewes presented with a history of chronic serosanguinous vaginal discharge. Age ranged from 5 to 11 years. Medical treatment with cloprostenol (Juramate, Jurox) and oxytocin (Syntocin, Ilium) failed in two ewes. A decision to surgically manage the cases was made. Midline laparotomy and surgical ovariohysterectomy resulted in permanent resolution of clinical signs. The first uterus and ovaries were submitted for histopathological examination and hydrometra was confirmed. Hydrometra is a known cause of infertility in sheep however more frequently noted as an incidental finding on abattoir specimens. It is an uncommon histopathological diagnosis. This case report expands the differentials for vaginal discharge in ewes, provides details of surgical correction of hydrometra and highlights the increased likelihood of unusual clinical presentations in older livestock kept as pets.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79834400,"openaccessinfo":{"externalids":{"MAG":"2774847086","ACL":null,"DOI":"10.1136\/vetreccr-2017-000555","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Chronopharmaceutics, the drug delivery based on circadian rhythm is recently gaining much attention worldwide. Keeping an objective celecoxib pulsatile core-in-cup tablet was designed to deliver a rapid or transient and quantified drug after a predetermined lag period. Celecoxib core tablet was prepared by direct compression method and is used to prepare a set of core-in-cup tablets with swellable and rupturable polymers with different proportions with impermeable cup ethyl cellulose. Tablets were evaluated for precompression, postcompression and in vitro dissolution. The drug polymer interaction was studied by FTIR. The precompression data of core\/core-in-cup tablet were within the acceptable limit and they can be compressed directly into tablets. The hardness, friability and uniformity in weight and disintegration time results were in accordance with the standard limit. The lag time is dependents on rupturing property of ehtyl cellulose and swelling property polymers. In all the formulations the best fit model was found to be peppas with exponential n value is > 1 indicates the drug release follows super case II transport mechanism. The initial burst release was observed after lag time and drug release was extended up to 12hr in all formulations. The in vitro drug release studies suggest that core-in-cup tablet prepared with ethyl cellulose and sodium alginate shows higher lag time than that of remaining formulations due to more swelling and delayed rupturing properties of sodium alginate and ethyl cellulose.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":136275915,"openaccessinfo":{"externalids":{"MAG":"2607251070","ACL":null,"DOI":"10.5958\/0974-360X.2017.00142.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, we compared visually evoked potentials (VEP) in healthy rats and rats following traumatic brain injury. Traumatic brain injury was modelled by the method of controlled cortical impact. The electrical activity of the brain cortex was registered using nichrome electrodes. Responses in primary and secon dary motor cortex areas, as well as in the area of primary sensory cortex over the hippocampus, were evoked by 3 Hz white light fl ashes on the 3rd and 7th day after the operation. The latencies and amplitudes of N1, P2, N2, P3 \u0438 N3, as well as the duration and amplitudes of inter-peak intervals, were calculated. It is shown that unilateral traumatic damage of the motor cortex area and underlying regions in rats does not signifi cantly reduce the number of VEP peaks. However, in most of the animals, the N1 component was absent in the area of damage.In comparison with healthy rats, traumatized rats demonstrated an increased latency of N1 and N3 peaks on the 3rd day after the operation followed by their return to normal values on the 7th day. In addition, traumatized rats showed a higher P2 amplitude in regions remote from the traumatized cortex area on the 3rd day; however, the P2 amplitude was lower in the injury area on the 7th day. The obtained results indicate that the registration and analysis of VEP can be used for localizing the traumatized area and to analyse the dynamics of the brain functional state in rats with brain trauma.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":240776551,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.33647\/2074-5982-16-2-68-77","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.33647\/2074-5982-16-2-68-77","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We report experiments on buoyant-thermocapillary instabilities in differentially heated liquid layers. The results are obtained for a fluid of Prandtl number 10 in a rectangular geometry with different aspect ratios. Depending on the height of liquid and on the aspect ratios, the two-dimensional basic flow destabilizes into oblique traveling waves or longitudinal stationary rolls, respectively, for small and large fluid heights. Temperature measurements and space\u2013time recordings reveal the waves to correspond to the hydrothermal waves predicted by the linear stability analysis of Smith and Davis J. Fluid Mech. 132, 119 1983. Moreover, the transition between traveling and stationary modes agrees with the work by Mercier and Normand Phys. Fluids 8, 1433 1996 even if the exact characteristics of longitudinal rolls differ from theoretical predictions. A discussion about the relevant nondimensional parameters is included. In the stability domain of the waves, two types of sources have been evidenced. For larger heights, the source is a line and generally evolves towards one end of the container leaving a single wave whereas for smaller heights, the source looks like a point and emits a circular wave which becomes almost planar farther from the source in both directions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2014-10":1,"2013-48":1,"2024-26":1}},"corpusid":55493377,"openaccessinfo":{"externalids":{"MAG":"2057426049","ACL":null,"DOI":"10.1063\/1.1398536","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/dadun.unav.edu\/bitstream\/10171\/1786\/1\/2001.PhF13.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper is concerned with the state estimation for neural networks with two additive time-varying delay components. Three cases of these two time-varying delays are fully considered: 1) both delays are differentiable uniformly bounded with delay-derivative bounded by some constants; 2) one delay is continuous uniformly bounded while the other is differentiable uniformly bounded with delay-derivative bounded by certain constants; and 3) both delays are continuous uniformly bounded. First, an extended reciprocally convex inequality is introduced to bound reciprocally convex combinations appearing in the derivative of some Lyapunov\u2013Krasovskii functional. Second, sufficient conditions are derived based on the extended inequality for three cases of time-varying delays, respectively. Third, a linear-matrix-inequality-based approach with two tuning parameters is proposed to design desired Luenberger estimators such that the error system is globally asymptotically stable. This approach is then applied to state estimation on neural networks with a single interval time-varying delay. Finally, two numerical examples are given to illustrate the effectiveness of the proposed method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206670135,"openaccessinfo":{"externalids":{"MAG":"2605988318","ACL":null,"DOI":"10.1109\/TCYB.2017.2690676","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was undertaken to determine the possible mechanisms of actions of monensin and digoxin by using isolated guinea-pig ventricular myocytes. Since Ca2+ is the major signal for triggering contraction of cardiac muscle, the objective of this study was to determine whether monensin and digoxin affect the [Ca2+]i of cardiac myocytes and if so is this effect due to an increase in [Na+]i. Three different concentrations of digoxin (0.3, 1 and 3 micromol\/l) and three different concentrations of monensin (0.3, 1 and 3 micromol\/l) were used. Each treatment was monitored for two hours by using computerized fluoroscopy. Both digoxin and monensin increased the [Ca2+]i and accelerated the onset time of [Ca2+]i increase in a dose-dependent manner. Normal myocytes (loaded with fura-2 for 30 min before the treatment) were also compared with 'weakened' myocytes (loaded with fura-2 for 3 h before the treatment to create a 'weakened' condition). It was found that although 0.3 micromol\/l monensin and digoxin did not change the [Ca2+]i in normal myocytes, they increased the [Ca2 +]i in 'weakened' myocytes. Finally, a Na+-free medium was used to demonstrate the effect of [Na+]o on both monensin- and digoxin-induced increases in [Ca2+]i. It was found that digoxin did not increase the [Ca2+]i in the Na+-free medium. Although monensin increased the [Ca2+]i in the Na+-free solution, this increase was not as large as in the Na+-containing medium. The results of the study led to the conclusion that the positive inotropic effect of digoxin depends on [Na+]o. However, monensin increases [Ca2+]i in Na+-dependent and -independent ways. An addition conclusion was that 'weakened' myocytes are more sensitive to the monensin and digoxin treatment than normal myocytes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43484496,"openaccessinfo":{"externalids":{"MAG":"1998833041","ACL":null,"DOI":"10.1046\/J.1439-0442.2002.00414.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nIn a three-arm randomized control trial, this study compared the efficacy of dental health education (DHE) with or without a planning intervention on adherence to oral health-related behaviours.\n\n\nMETHODS\nWomen (N=154) in their second trimester of pregnancy attending three maternal healthcare clinics in Kuwait completed an assessment of social cognitions and oral health behaviours before a debris and gingival assessment (Plaque Index [PI], Gingival Index [GI]) was undertaken; this was repeated at 1\u00a0month. In addition to treatment as usual (TAU), which was a demonstration of OH practices, intervention participants received one of two interventions: (i) DHE, which targeted social cognitions; or (ii) DHE and planning (DHE&P), which targeted social cognitions and intentions to undertake oral health behaviours. The TAU group was given a standard oral hygiene leaflet.\n\n\nRESULTS\nAt Time one (T1) 154 women were eligible and randomly allocated to the three groups, respectively: treatment as usual (TAU)=53; DHE=53; DHE and planning=48. At Time two (T2), the number of women in each group completing the intervention (N=90) was, respectively, as follows TAU=28; DHE=30; DHE&P=32. There were no demographic differences between the groups at baseline. The mean age of women was 27.80\u00b1SD 5.40; 43% (n=38) had a high school level education. A mixed factor ANOVA analysis demonstrated that all women improved their PI (F=94.343 df=1 P=.001) and GI (F=73.138 df=1 P=.001) scores. There were no differences in self-reported oral hygiene and PI and GI by intervention group. The social cognition models (SCM) constructs changed over time in all women (N=90) except barriers to attendance (F=1.067 df=1 P=.305). There were no statistically significant differences in SCM constructs by intervention group at T2. All women reported increasing the frequency of toothbrushing and flossing.\n\n\nCONCLUSIONS\nThe provision of information using a simple leaflet improved the adherence of Kuwaiti pregnant with toothbrushing and flossing advice, while the addition of DHE targeting social cognitions and planning conferred no additional benefits.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34989585,"openaccessinfo":{"externalids":{"MAG":"2626814317","ACL":null,"DOI":"10.1111\/cdoe.12311","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/kclpure.kcl.ac.uk\/ws\/files\/72620677\/The_effect_of_dental_KHAMIS_Publishedonline14June2017_GREEN_AAM.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"A search for electroweak production of supersymmetric particles is performed in two-lepton and three-lepton final states using recursive jigsaw reconstruction. The search uses data collected in 2015 and 2016 by the ATLAS experiment in $\\sqrt{s}$ = 13 TeV proton--proton collisions at the CERN Large Hadron Collider corresponding to an integrated luminosity of 36.1 fb$^{-1}$. Chargino-neutralino pair production, with decays via W\/Z bosons, is studied in final states involving leptons and jets and missing transverse momentum for scenarios with large and intermediate mass-splittings between the parent particle and lightest supersymmetric particle, as well as for the scenario where this mass splitting is close to the mass of the Z boson. The latter case is challenging since the vector bosons are produced with kinematic properties that are similar to those in Standard Model processes. Results are found to be compatible with the Standard Model expectations in the signal regions targeting large and intermediate mass-splittings, and chargino-neutralino masses up to 600 GeV are excluded at 95% confidence level for a massless lightest supersymmetric particle. Excesses of data above the expected background are found in the signal regions targeting low mass-splittings, and the largest local excess amounts to 3.0 standard deviations.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":125706805,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1103\/PhysRevD.98.092012","PubMedCentral":null,"ArXiv":"1806.02293"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Geriatric patients with hip fractures have high mortality. This study aimed to compare the mortality and rehospitalization of recipient and nonrecipient of outpatient rehabilitation in hip-fractured elderly. This retrospective cohort study used nationwide claims data in Taiwan and included 3585 senior citizen patients admitted for hip fractures between January 1, 2005, and December 31, 2012. Patients were divided into the recipient (717) and nonrecipient (2868) of outpatient rehabilitation during the first 3 months after hospital discharge. Each patient was followed up for 1 year. Mortality rates of hip-fractured elderly after discharge during the first 3-month period in different groups were analyzed with Chi-square test. Cox proportional hazards regression model was employed for both death and rehospitalization risk analyses. The mortality rate of the rehabilitation group was lower than that of the nonrehabilitation group (12.69% vs 16.70%, P\u200a<\u200a.05). A more beneficial effect was observed for patients receiving continuous rehabilitation. The rehabilitation group had a lower adjusted risk of death [hazard ratio (HR)\u200a=\u200a0.74; 95% confidence interval (95% CI): 0.59\u20130.94] than that of the nonrehabilitation group. However, the rehabilitation group was at a higher risk of rehospitalization (HR\u200a=\u200a1.37; 95% CI: 1.22\u20131.55). Hip-fractured elderly receiving outpatient rehabilitation have a lower risk of death but a higher risk of rehospitalization than those not receiving rehabilitation within 1 year after fracture.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":13696602,"openaccessinfo":{"externalids":{"MAG":"2799494663","ACL":null,"DOI":"10.1097\/MD.0000000000010644","PubMedCentral":"5959428","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pedestrian Detection (PD) is one of the most studied issues of driver assistance systems. Although a tremendous effort is already given to create datasets and to develop classifiers for cars, studies about railway systems remain very limited. This article shows that direct application of neither existing advanced object detectors (such as AlexNet, VGG, YOLO etc.), nor specifically created systems for PD (such as Caltech\/INRIA trained classifiers), can provide enough performance to overcome railway specific challenges. Fortunately, it is also shown that without waiting the collection of a mature dataset for railways as comprehensively diverse and annotated as the existing ones for cars, a Transfer Learning (TL) approach to fine-tune various successful deep models (pre-trained using both extensive image and pedestrian datasets) to railway PD tasks provides an effective solution. To achieve TL, a new RAilWay PEdestrian Dataset (RAWPED) is collected and annotated. Then, a novel three-stage system is designed. At its first stage, a feature-classifier fusion is created to overcome the localization and adaptation limitations of deep models. At the second stage, the complementarity of the transferred models and diversity of their results are exploited by conducted measurements and analyses. Based on the findings, at the third stage, a novel learning strategy is developed to create an ensemble, which conditionally weights the outputs of individual models and performs consistently better than its components. The proposed system is shown to achieve a log average miss rate of 0.34 and average precision of 0.93, which are significantly better than the performance of compared well-established models.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":216510283,"openaccessinfo":{"externalids":{"MAG":"3014754236","ACL":null,"DOI":"10.1109\/TVT.2020.2983825","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report a case of Miller Fisher syndrome in an 80-year-old woman who presented with a 3-day history of worsening dizziness associated with vertigo. The patient had an episode of upper respiratory tract infection one week earlier. She later developed diplopia in bilateral lateral gaze and drooping of eyelids. She was treated conservatively without the use of intravenous immunoglobulin or plasmapharesis. Her symptoms improved gradually after 2 weeks of hospitalisation. At the 10-week follow-up, she had regained all the reflexes and full ocular movements with no residual ptosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":74587453,"openaccessinfo":{"externalids":{"MAG":"2182311685","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this research is to study the feasibility of the solar(hot fluid) driven NH\u2083\/H\u2082O absorption chiller, made by re-manufacturing of Gas fired NH\u2083\/H\u2082O absorption chiller. This experimental study is performed with the temperature of the inlet hot fluid of generator. In order to determine the inlet temperature of the generator, which gives maximum COP, the experimental data are obtained with various hot fluid supply temperature in range of 130\u223c170\u2103. Remodeled chiller is operated with periodical cooling effect, which due to mixture subcooled pool boiling, then the COP is evaluated in average. The maximum COP(\u223c0.36) is at 160\u2103. The temperature is stable operation temperature range of typical vacuum collector. It offers a feasibility of solar driven NH\u2083\/H\u2082O absorption chiller.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":95687367,"openaccessinfo":{"externalids":{"MAG":"2012952932","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nMaintaining body temperature and reducing stress are important challenges in bathing preterm infants. Swaddle bathing, which includes in itself the principles of developmental care, can be used as a low-stress and appropriate bathing method for premature infants. Given the limitations of the researches carried out on this bathing method, the present study was conducted with the aim of comparing the effects of swaddled and conventional bathing methods on body temperature and crying duration in premature infants.\n\n\nMETHODS\nIn this randomized clinical trial study, 50 premature infants hospitalized in Neonatal Intensive Care Unit (NICU) who were eligible for the study were divided by random allocation into two experimental and control groups. The infants in the experimental group were bathed using the swaddle bathing method and the infants in the control group were bathed using the conventional bathing method. Body temperature was measured 10 minutes before and 10 minutes after the bath. To record the crying, the infants' faces were filmed during the bath. The data were analyzed using chi-squared test, independent t-test, paired t-test and Mann-Whitney U test.\n\n\nRESULTS\nThe mean temperature loss was significantly less in the swaddle-bathed newborns compared to the conventionally-bathed newborns. Furthermore, crying time was significantly less in the experimental group than in the control group.\n\n\nCONCLUSION\nGiven the positive effect of swaddled bathing in maintaining body temperature and reducing stress, it can be used as an appropriate bathing method in NICU.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10485144,"openaccessinfo":{"externalids":{"MAG":"2265549980","ACL":null,"DOI":"10.5681\/jcs.2014.009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In a pharmacokinetic study with Humate\u2010P\u00ae including six patients with various types of von Willebrand disease, a median half\u2010life of 11.3\u2003h for vWF:RCoF and of 15.2\u2003h for vWF:Ag was found. The median value of in vivo recovery (IVR) was estimated for vWF:RCoF as 2.10 IU\u2003dL\u22121 plasma per 1 substituted IU\u2003kg\u22121 b.w. (or 73%), for vWF:Ag as 1.88 IU\u2003dL\u22121 plasma per 1 substituted IU kg\u22121 b.w. (or 69%); and for FVIII:C as 2.69 IU dL\u22121 plasma per 1 IU\u2003kg\u22121 b.w. (or 99%). Transient postinfusion shortening or normalization of previously prolonged bleeding time was observed in all patients. In a retrospective study involving 97 patients with various von Willebrand disease types, clinical efficacy and safety of treatment with Haemate\u2010P\u00ae in 73 surgical interventions, 344 separate bleeding events, 93 other events and 20 cycles of prophylactic treatment were evaluated. The clinical efficacy was rated good to excellent in 99% of the surgeries, in 97% of the bleeding episodes, in 86% of the other events, and in all prophylactic treatments. The overall tolerability was good. Adverse events possibly or probably associated with use of Humate\u2010P\u00ae\/Haemate\u2010P\u00ae were rare, of non\u2010serious nature and mild to moderate in their intensity.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":36286138,"openaccessinfo":{"externalids":{"MAG":"1569277262","ACL":null,"DOI":"10.1046\/j.1365-2516.1998.0040s3033.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The dearth of known cladoceran introductions is paradoxical, as their parthenogenetic lifestyle and desiccation-resistant resting eggs make them excellent candidates for invaders. Unfortunately, the biogeography and systematics of the group are poorly studied so natural species distributions and the importance of invasions are difficult to assess. In this study we conducted an allozyme analysis comparing populations of the common lacustrine cladoceran Daphnia galeata from North America and Europe. Four populations from the lower Laurentian Great Lakes were genetically intermediate between North American and European populations. This geographic pattern of genetic variation suggests that the introduction of European D. galeata has gone unnoticed, and that extensive hybridization with native Daphnia has resulted. North American and European populations were not only genetically distinct but mated non-randomly under sympatry, supporting a taxonomic split at the species level. Our study suggests that insights into evolutionary and ecological processes and conservation biology may be lost when genetic markers are ignored in the biogeographical study of morphologically conserved groups.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":84734222,"openaccessinfo":{"externalids":{"MAG":"2019166706","ACL":null,"DOI":"10.1098\/rspb.1993.0141","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"CuFeO(2) is one of the multiferroic materials and is the first case that the electric polarization is not explained by the magnetostriction model or the spin-current model. We have studied this material using soft x-ray resonant diffraction and found that superlattice reflection 0 1-2q 0 appears in the ferroelectric and incommensurate magnetic ordered phase at the Fe L(2,3) absorption edges and moreover that the rotation of the x-ray polarization such as from \u03c3 to \u03c0 or from \u03c0 to \u03c3 is allowed at this reflection. These findings definitely provide direct evidence that the 3d t(2g\u2193) orbital state of Fe ions has a long-range order in the ferroelectric state. The spin-orbit interaction in Fe ions plays a crucial role to the ferroelectricity in CuFeO(2), coupling two nontrivial spin and orbital orders, both of which break the crystal symmetry.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19396970,"openaccessinfo":{"externalids":{"MAG":"2316832043","ACL":null,"DOI":"10.1103\/PHYSREVLETT.109.127205","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Early or late posttransplant opportunistic infections are among the leading complications after liver transplant. The source of early posttransplant opportunistic infections is usually the patient, the implantation of an infected graft, contamination during a surgical procedure, or invasive interventions performed at the intensive care unit. A 10-year-old male patient with Wilson disease (Pediatric End-Stage Liver Disease Score of 42, Child-Pugh score of 12, total bilirubin 40 mg\/dL, platelet count 55?000\/mL, hemoglobin level 6.3 g\/dL, albumin level 1.7 g\/dL, urinary copper level 4305 \u03bc\/24 h) was closely monitored in the pediatric intensive care unit of our liver transplantation center for care of a worsened general status. A deceased-donor liver transplant was performed using a right lobe liver graft (ex vivo split) obtained through the national organ sharing network. The patient developed rightward deviation of eyes and altered consciousness after the procedure and underwent cranial magnetic resonance imaging and computerized tomography examinations. The cranial magnetic resonance image, taken on the third postoperative day, revealed lesions consistent with embolic infarction, and the computed tomography scan, taken on the eighth day, showed intracerebral hemorrhage. Decompressive craniotomy, which included hematoma drainage and catheter placement, was performed. Culture and histopathologic examinations of the hematoma material revealed a Penicillium species of fungi. However, the patient died before a definitive diagnosis was made. The aim of this report is to raise awareness on early posttransplant opportunistic infections of the central nervous system presenting with intracranial hemorrhage following liver transplant.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22195921,"openaccessinfo":{"externalids":{"MAG":"2749718598","ACL":null,"DOI":"10.6002\/ect.2016.0274","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Human trafficking in this era has been conceptualized as a global event that is likened to slavery because of the inhumane treatment that the victims go through. The scope and the criminal aspect of it demands police initiative to curb the menace. The current researcher used semi-structured qualitative interview, direct observation, and review of documents to gather data from Ghana Police Service and some anti-human trafficking institutions in Ghana to identify the nature, scope and responses to reduce or eradicate this menace that has detrimental effect on the people of Ghana, as a case study. Contemporarily, in terms of origin, destination and transit of people to engage in this criminal act, the menace put Ghana into Tier Two Watch-List classification in 2015 on the international level. Human trafficking in Ghana was characterized as violence, debt bondage, exploitation, deprivation of the freedom of the victims, and confiscation of travelling and other documents. The study revealed that the government of Ghana had put in only a minimal effort to curb the menace, and that the trafficking of people had created a security concern that the police must be apt to control. There is a recommendation that the Government of Ghana puts in maximal effort to educate the people and equip the Police service in Ghana to enable the service take tough action to ensure the maximum implementation of the regulations against human trafficking. \n \n Key words: Human trafficking, Ghana, policing, inhumane treatment, criminalization, border crime.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":157488813,"openaccessinfo":{"externalids":{"MAG":"2550082367","ACL":null,"DOI":"10.5897\/IJPDS2016.0282","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Imaging subsurface structures, such as salt domes, magma reservoirs or subducting plates, is a major challenge in geophysics. Seismic imaging methods are, so far, the most precise methods to open a window into the Earth. However, the methods may not yield the exact depth or size of the imaged feature and may become distorted by phenomena such as seismic anisotropy, fluid flow, or compositional variations. A useful complementary method is therefore to simulate the mechanical behaviour of rocks on large timescales, and compare model predictions with observations. Recent studies have used the (non-linear) Stokes equations and geometries from seismic studies in combination with an adjoint-based approach to invert for rheological parameters that are consistent with surface observations such as GPS velocities. Nevertheless, it would be useful to use other surface observations, such as principal stress directions, as constraints as well. Here, we derive the adjoint formulation for the case that principal stress directions are used as observables with respect to rheological parameters. Both an algebraic and a discretized derivation of the adjoint equations are described. This thus enables the usage of two data fields - surface velocities and stress directions - as a misfit for the inversion. We test the performance of the inversion for principal stress directions on simplified 3-D test cases.\n Finally, we demonstrate how the adjoint approach can be used to compute 3-D geodynamic sensitivity kernels, which highlight the areas in the model domain that have the largest impact on the misfit value of a particular point. This provides a simple, yet powerful, way to visualize which parts of the model domain are of key importance if changing rheological constants.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":221664136,"openaccessinfo":{"externalids":{"MAG":"3042261039","ACL":null,"DOI":"10.1093\/gji\/ggaa344","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.31223\/x5h04k","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"After a long period of unpopularity, philosophical realism is enjoying a revival. According to some of its contemporary versions, the world consists in just what the ordinary view of the world assumes, while the unobservable entities postulated by scientific theories are nothing more than fictions. Some other versions, in contrast, accept only the ontology of the best scientific theories and assume a reductionist or eliminationist stance towards the entities postulated by common sense. In this article it is argued that, because of their respective unilateralism, both these versions of realism are unsatisfying and that an acceptable new realism should adopt, in a liberal naturalist spirit, a realist attitude regarding both the common sense and the scientific views of the world.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":145176956,"openaccessinfo":{"externalids":{"MAG":"2150237826","ACL":null,"DOI":"10.1093\/MONIST\/ONV006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we present a numerical implementation of the Decoupled Potential Integral Equation DPIE. The DPIE formulation allows to describe the scattered electromagnetic field by solving a boundary value problem for the vector and scalar potentials Ascat and \u00f8scat separately. The formulation allows to obtain the exact scattered electric and magnetic fields for any frequency \u03c9 \u2265 0. The formulation is immune to low frequency breakdown, high density mesh breakdown and internal resonances. The formulation can be applied to multiply connected geometries without loop search. In this paper we present a low frequency multilevel fast multipole implementation of the DPIE based on a flat triangular discretization with piecewise constant basis functions and collocation method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1377247,"openaccessinfo":{"externalids":{"MAG":"1953148201","ACL":null,"DOI":"10.1109\/APS.2015.7304760","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Exploring the changes in ecosystem service value (ESV) caused by land use transition is important for regional ecological protection. According to the land use data from 2000 to 2020, the alterations in the land use and ESV in Yunnan over the past 20 years were calculated and analyzed. At the same time, spatial autocorrelation analysis was established to analyze the spatial relationships of ESV in 16 states and cities. The results show that from 2000 to 2020, cultivated land, grassland and unused land are on a decreasing trend, while forest land, water body and built-up land are on an increasing trend, with the largest change in built-up land. The total ESV is on an increasing trend, with water supply, gas regulation, climate regulation, environmental purification and hydrological regulation being the highest value of individual services. Spatially, the total ESV showed that high levels were in the northwest, southwest and east, and low levels were in the northeast, west and central parts. At the same time, it shows a positive spatial correlation with a weakening trend. It is dominated by high\u2013high cluster and low\u2013low cluster. The change in the value of ecological services in forest land, grassland and water body have a greater impact on the change in total service value in the region, and was the main contributing and sensitive factor.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":254446553,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/land11122217","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-445X\/11\/12\/2217\/pdf?version=1670322518","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Several studies indicate a relationship between vitamin D and cardiovascular disease. Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). VDRs have been identified in almost all tissues, including vascular smooth muscle cells, cardiomyocytes, and endothelial cells. The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Studies investigating the relationship between VDR genotypes and left ventricular hypertrophy revealed a highly significant association with the BsmI Bb heterozygous genotype. There are conflicting data on the action of vitamin D in left ventricular hypertrophy. Experimental as well as observational studies and small clinical trials have suggested that vitamin D administration may favorably influence left ventricular hypertrophy, whereas large randomized clinical trials have shown negative results. However, a beneficial effect on the left atrial volume index and the duration of hospitalization were observed in patients treated with vitamin D analogs. Larger clinical trials with robust clinical end points are needed to confirm that vitamin D is effective in preventing cardiovascular disease in chronic kidney disease patients and in general population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22457483,"openaccessinfo":{"externalids":{"MAG":"2085321104","ACL":null,"DOI":"10.1053\/j.jrn.2014.10.022","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Delayed diagnosis of atrial \ufffdbrillation (AF) and congestive heart failure (CHF) can lead to death. Early diagnosis of these cardiac conditions is possible by manually analyzing electrocardiogram (ECG) signals. However, manual diagnosis is complex, owing to the various characteristics of ECG signals. Several studies have reported promising results using the automatic classi\ufffdcation of ECG signals. The performance accuracy needs to be improved considering that an accurate classi\ufffdcation system of AF and CHF has the potential to save a patient's life. An optimal ECG signal classi\ufffdcation system for AF and CHF has been proposed in this study using a one-dimensional convolutional neural network (1-D CNN) to improve the performance. A total of 150 datasets of ECG signals were modeled using the1-D CNN. The proposed 1-D CNN algorithm, provided precision values, recall, f1-score, accuracy of 100%, and successfully classi\ufffded raw data of ECG signals into three conditions, which are normal sinus rhythm (NSR), AF, and CHF. The results showed that the proposed method outperformed the previous methods. This approach can be considered as an adjunct for medical personnel to diagnose AF, CHF, and NSR.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":236569595,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We propose in this paper two ways for diminishing the size of a multilayered neural network trained to recognise French vowels. The first deals with the hidden layers: the study of the variation of the outputs of each node gives us information on its very discrimination power and then allows us to reduce the size of the network. The second involves the input nodes: by the examination of the connecting weights between the input nodes and the following hidden layer, we can determinate which features are actually relevant for our classification problem, and then eliminate the useless ones. Through the problem of recognising the French vowel \/a\/, we show that we can obtain a reduced structure that still can learn.<>","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":53892760,"openaccessinfo":{"externalids":{"MAG":"1530066485","ACL":null,"DOI":"10.1109\/ICNN.1994.374981","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Certain problems in the design of digital systems for use in cultural heritage and the humanities have proved to be unexpectedly difficult to solve. For example, Why is it difficult to locate ourselves and understand the extent and shape of digital information resources? Why is digital serendipity still so unusual? Why do users persist in making notes on paper rather than using digital annotation systems? Why do we like to visit and work in a library, and browse open stacks, even though we could access digital information remotely? Why do we still love printed books, but feel little affection for digital e-readers? Why are vinyl records so popular? Why is the experience of visiting a museum still relatively unaffected by digital interaction? The article argues that the reasons these problems persist may be due to the very complex relationship between physical and digital information and information resources. I will discuss the importance of spatial orientation, memory, pleasure, and multi-sensory input, especially touch, in making sense of, and connections between physical and digital information. I will also argue that, in this context, we have much to learn from the designers of early printed books and libraries, such as the Priory Library and that of John Cosin, a seventeenth-century bishop of Durham, which is part of the collections of Durham University library.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":29988628,"openaccessinfo":{"externalids":{"MAG":"2732516808","ACL":null,"DOI":"10.1093\/llc\/fqx036","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/dsh\/article-pdf\/32\/suppl_2\/ii135\/21299039\/fqx036.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The ban on women between the ages of 10 and 50 years entering Sabarimala temple has been something of a sleeper scandal. For decades there has been a low-level disagreement within Kerala regarding the ban's parameters and validity, but the issue received relatively little traction in the public sphere. Even after the High Court of Kerala's decision in S Mahendran v Secretary, Travancore Devaswom Board (TDB) and Others (1991) (henceforth Mahendran), debate over the nature and constitutionality of the ban remained relatively muted. All of this changed in 2006. For over a decade, and especially for the last few years, Sabarimala has consistently commanded attention at the state and national levels. Moreover, and notwithstanding a lengthy Supreme Court verdict, public interest in the ban shows no signs of waning. This article examines some of the arguments and implications of the apex court's decision in the India Young Lawyers Association (IYLA) v State of Kerala. While the Court's conclusion was both unsurprising and easily justified given the constitutional principles and existing precedent, its analysis\u2014and occasionally, the lack thereof\u2014ought to give observers a pause regardless of where they stand with respect to the ban.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":159622489,"openaccessinfo":{"externalids":{"MAG":"2920711087","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Clutter rejection is a key technique used by passive radars for target detection. Especially when using Single Frequency Network (SFN) configuration, the multipath clutter and ground clutter increase several times more than during a single illuminator situation, which means that the clutter extends in both the spatial and temporal dimensions. The high amount of clutter occupies numerous degrees of freedom when conventional spatial or temporal processing is used, leading to a large array requirement, a huge computational cost, or even a complete failure. This paper investigates a novel subcarrier-based processing technique that is tailored for Orthogonal Frequency Division Multiplex (OFDM) modulation with a Cyclic Prefix (CP-OFDM) to avoid the above- mentioned predicament. The algorithm principle is initially illustrated and followed by a discussion about the unique characteristics of Subcarrier-based Spatial Adaptive Processing (SSAP), which include the Doppler response and its unusual main-lobe clutter case. Then, the robustness is researched by evaluating the performance under relaxed basic assumptions. The conclusions are demonstrated by conducting test using simulated and real datasets.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":114991039,"openaccessinfo":{"externalids":{"MAG":"2467642558","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 57-year-old woman with a large acoustic schwannoma proven by MRI underwent Tc-99m methoxy isobutyl isonitrile (MIBI) stress myocardial imaging for preoperative cardiac evaluation. Brain SPECT was performed while she was walting for resting myocardial scintigraphy. This study demonstrated markedly increased radiotracer uptake by the tumor in the left cerebellopontine angle. The most common tumors occurring in the cerebellopontine angle and internal auditory canal are acoustic neuromas","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":27704482,"openaccessinfo":{"externalids":{"MAG":"2051379887","ACL":null,"DOI":"10.1097\/00003072-199402000-00018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The potential to damage synthetic graphite is high during the pyrolysis of pitch\/coke composite material in processing of carbon\/carbon components. Exact modeling of heating patterns could optimize the preparation conditions in order to obtain high quality products. A capillary\u2013cell model was built to evaluate the internal pressure resulting from volatile matter in green carbon blocks during carbonization. The theoretical model for heating patterns was proposed by considering the influence of heating rates on the internal pressure and the thermal stress during the heat-treatment procedure. The results showed that the theoretical heating rates were mainly controlled by mass transfer in the range 467\u2013850 K and by heat transfer in other temperature ranges. The values calculated by the developed model were compared with the industrial results, and the validity of the proposed method for the prediction of heating patterns is evaluated.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100730975,"openaccessinfo":{"externalids":{"MAG":"2334787371","ACL":null,"DOI":"10.1021\/EF201055R","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nThe impairment of gastric acid barrier caused by Helicobacter pylori (H. pylori) at the onset of infection may predispose to small bowel bacterial overgrowth, which could contribute to persistent diarrhea.\n\n\nMETHODS\nUsing the 13C-urea breath test, we determined the prevalence of H. pylori infection in 123 Nicaraguan children from Tipitapa, aged 1 to 65 months, from a low socioeconomic background.\n\n\nRESULTS\nThe overall prevalence of H. pylori infection was 77.2% (95\/123). The prevalence varied with age and was significantly (p < 0.001) higher in infants < or = 12 months than in children aged 13-65 months, 91% (57\/63) as against 63% (38\/60). H. pylori infection was present in 44 of 59 (75%) children suffering from persistent diarrhea compared with 51 of 64 (80%) age-matched asymptomatic controls. In the diarrheal group, 20 of 59 (34%) children presented with malnutrition, and 16 (80%) of them showed H. pylori infection. In the control group, 20 of 64 (31%) were malnourished, and 14 (70%) of them showed H. pylori infection.\n\n\nCONCLUSIONS\nIn Nicaragua, H. pylori is acquired in early infancy. The high prevalence among children in the first 12 months of life and the lower infection rate between 1 and 5 years of age suggest a loss or clearance of infection, also an occasional finding in adults. H. pylori infection appears to be not a risk factor for persistent diarrhea or malnutrition in Nicaraguan children.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":25169157,"openaccessinfo":{"externalids":{"MAG":"2142169517","ACL":null,"DOI":"10.1097\/00005176-199707000-00014","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.lww.com\/jpgn\/Fulltext\/1997\/07000\/Prevalence_of_Helicobacter_pylori_Infection_in.14.aspx","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a family of graph partition similarity measures that take the topology of the graph into account. These graph-aware measures are alternatives to using set partition similarity measures that are not specifically designed for graphs. The two types of measures, graph-aware and set partition measures, are shown to have opposite behaviors with respect to resolution issues and provide complementary information necessary to compare graph partitions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":49543933,"openaccessinfo":{"externalids":{"MAG":"2811424779","ACL":null,"DOI":"10.1109\/TPAMI.2020.3009862","PubMedCentral":null,"ArXiv":"1806.11494"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Memories occupy most of the silicon area in nowadays' system-on-chips and contribute to a significant part of system power consumption. Though widely used, nonvolatile Flash memories still suffer from several drawbacks. Magnetic random access memories (MRAMs) have the potential to mitigate most of the Flash shortcomings. Moreover, it is predicted that they could be used for DRAM and SRAM replacement. However, they are prone to manufacturing defects and runtime failures as any other type of memory. This article provides an up-to-date and practical coverage of MRAM test and reliability solutions existing in the literature. After some background on existing MRAM technologies, defectiveness and reliability issues are discussed, as well as functional fault models used for MRAM. This article is dedicated to a summarized description of existing test and reliability improvement methods developed so far for various MRAM technologies. The last part of this article gives some perspectives on this hot topic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2024-26":1,"2024-10":1,"2024-30":1}},"corpusid":229252105,"openaccessinfo":{"externalids":{"MAG":"3097826648","ACL":null,"DOI":"10.1109\/JPROC.2020.3029600","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The objective of the present study was to determine the ability of 17\u03b2-estradiol (E2) and conjugated forms of E2 (E2 conjugated to BSA [E2-BSA] and a novel conjugate, E2 conjugated to a small peptide [E2-PEP]) to prevent the GnRH-induced secretion of LH and to determine the role of estradiol receptors (ERs) and ER subtypes (ER\u03b1, also known as ESR1, and ER\u03b2, also known as ESR2) in the mediation of the acute action of E2 in primary cultures of ovine pituitary cells. Preincubation of cells for 15 min with E2, E2-BSA, or E2-PEP prevented the GnRH-induced secretion of LH (P < 0.01). Treatment of cells with nonestrogenic steroid hormones did not affect secretion of LH when given alone, nor did these steroids impair the E2-induced inhibition of LH secretion (P > 0.1). Likewise, treatment of cells with the ER-antagonists tamoxifen, hydroxytamoxifen, or ICI 182\u200a780 did not affect (P > 0.1) secretion of LH when given alone but did prevent (P < 0.01) the inhibition by E2 and the E2-conjugates on GnRH-induced secretion of LH. When cells were treated with subtype-selective ER agonists, the ER\u03b1 agonist (propylpyrazole-triol), but not the ER\u03b2 agonist (diarylpropionitrile), decreased (P < 0.01) the GnRH-induced secretion of LH. In conclusion, the rapidity by which E2 prevented GnRH-induced release of LH in ovine pituitary cells suggests that this inhibition is mediated via a nongenomic action of E2. The inhibition of GnRH-induced secretion of LH proved to be steroid specific and mediated by ERs. It may occur specifically through ER\u03b1. The fact that E2-BSA or E2-PEP mimicked the action of E2 suggests that this effect was mediated by an ER associated with the plasma membrane.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46860967,"openaccessinfo":{"externalids":{"MAG":"2151054617","ACL":null,"DOI":"10.1095\/biolreprod.105.040329","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/73\/1\/115\/10563073\/biolreprod0115.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Osteoporosis in the elderly and senile can be compared with the epidemic of the 21st century due to the high prevalence and increased incidence among people who have survived the 50-year threshold, which make up the bulk of patients. Osteoporosis is associated with a significant increase in the risk of falls and fractures, leading to adynamia and an increased risk of death. Despite the insufficient knowledge of the pathogenesis of the disease, the available data have already allowed the development of preventive measures and treatment principles. Currently, there are preventive and therapeutic measures aimed at reducing the risk of falls, fractures and repeated fractures, however, earlier detection of the disease in old age is often difficult due to the characteristic features of geriatric patients. The polymorbidity, unexpressed clinical picture, the development of frailty syndrome, sarcopenia, social and mental maladaptation and an increase in the frequency of depression make the population of elderly and senile people vulnerable to an increased risk of osteoporosis, falls and fractures and associated hospitalizations and mortality. This review highlights the features of pathogenesis, clinical features, principles of treatment and prevention of osteoporosis in the older age group.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235012088,"openaccessinfo":{"externalids":{"MAG":"3138453787","ACL":null,"DOI":"10.14341\/osteo12352","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.14341\/osteo12352","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Ecological relationships between species richness and biomass production are increasingly thought to be pervasive across the globe. Yet, diversity\u2013production relationships have not been explored extensively for freshwater fish communities even though fisheries production provides key services to humans. Our aim was to evaluate the diversity\u2013production relationship of fish communities inhabiting freshwater streams across the Appalachian Mountain range and examine how diversity\u2013production relationships varied across streams possessing different thermal signatures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237350324,"openaccessinfo":{"externalids":{"MAG":"3184058440","ACL":null,"DOI":"10.1111\/ddi.13369","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/ddi.13369","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This research is aimed at comprehensively evaluating the condition of a road surface of a highway in satisfaction of its users. This research conducted an overall evaluation of a road surface condition by adding qualitative data, or a driver's satisfaction to the existing quantitative elements, whereas the existing research put its focus on a correlation analysis with quantitative factors and qualitative factors through a statistical method. As for an evaluation method, this research conducted an overall evaluation by using Grey System Theory which makes possible an integrated evaluation. The analyzed results make it possible to diagnose the current conditions of each section of object roads and to predict the potentially changeable conditions for the time to come. In addition, these analyzed results could hopefully be applied to the maintenance of freeways through diverse methods. It is hoped that the evaluation of a road surface condition of a highway in satisfaction of its user could be helpful to keeping up the satisfaction of a driver and passenger on the highway by more than a certain level. In addition, the analyzed data on the influence of data value observed by comprehensively evaluating a variety of elements could be used as a secondary means of the decision-making process in relation to road maintenance. On top of that, it could be used as a means of improving road maintenance system and offering the improved driving environment of the highway.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":111789775,"openaccessinfo":{"externalids":{"MAG":"2239007922","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrophysiological signal acquisition such as ECG and EEG play an important part in modern medical monitoring and diagnostics. The measurement of these very low-level, low-frequency signals are normally made from the skin with a directly coupled sensor utilizing a conductive gel to create a low resistance path for the charge. The application of the gel is tedious and time consuming as well as requiring a clinical environment and prevents long period measurements. In this paper, a contact-less, capacitively coupled sensor \u2014 without any need for gel \u2014 together with an electronic readout circuit using a PCB is presented. A design with a very high input impedance allows for measurements of signals with amplitudes down to a few tens of microvolts and at frequencies between a few hertz to tens of hertz. Measurements show that the circuit could detect an input signal of 25 \u03bcV at 10 Hz with an SNR of 9.7 dB.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":38035169,"openaccessinfo":{"externalids":{"MAG":"1981944564","ACL":null,"DOI":"10.1109\/BIOCAS.2010.5709631","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the information technology age that developed rapidly nowadays, technology progress is valuable than money and natural resources. This can be prooved by refering to increasing total number of handphone and personal computer user.Online Diary Application System that will be developed is a system that can be use by any user that has many functions. The functions that it has are reminder that comes with birthday reminder function, call reminder, meeting reminder and to do reminder. It also has financial summary function that divide 2 function that called budget and spent function. This system also has contact function and diary function. This system must has safety, so the unknown user cannot access this system as their wish.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":111610809,"openaccessinfo":{"externalids":{"MAG":"2277460379","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper deals with networked applications in the emerging field of online virtual worlds. Example applications include, e.g., Massively Multiplayer Online Computer Games (MMOG), networked e-learning, training and simulations, etc. Highly interactive virtual worlds bring a new security challenge: the multiple participants of such applications do not always show cooperative and intended behavior, but rather may act in an illegal way (cheating) which is harmful for other participants, thus intentionally or accidentally procuring illicit advantages for themselves. The paper studies the new challenge of cheating in virtual-world applications in three areas: a) system and application programming, b) economics, and c) law. The main contributions of our work are as follows: 1) We present a systematic classification of cheating threats in virtual worlds, and describe software solutions that help prevent them in future Internet-based applications; 2) We enhance the classical economic analysis of crime and punishment for applying it to virtual worlds; 3) We describe our development approach for networked virtual worlds and its implementation as the Real-Time Framework (RTF) which has been designed at the University of Muenster; 4) Finally, we explore the law aspects of cheating in virtual applications in the context of the legal system in Germany. The consideration of informatics aspects together with the corresponding problems of economics and law allows us to tackle virtual-world security in a holistic, systematic manner.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":28907788,"openaccessinfo":{"externalids":{"MAG":"201363405","ACL":null,"DOI":"10.3233\/978-1-60750-629-4-268","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For the features of high speed moving, sparse distribution, diversity of data service, etc., and high reliability and low latency of QoS demand when transmitting time-sensitive information in airborne tactical networks, we present a random access multi-channel medium access control protocol based on RS-Polar coding technology. In the protocol, by adopting error correcting coding technology of RS-Polar cascaded, the multi-packet reception technology, it can ensure the real-time and reliability of packet transmission without the use of channel reservation and time-slot allocation, and improve the network throughput effectively. By establishing the channel collision model and the multi packet reception model in the bursts propagation stage, the mathematical expressions of packet success probability, packet end-to-end delay and network throughput are derived. The simulation results show that packet end-to-end delay of the protocol is less than 2ms, and when the load is less than 2000 packet\/s, the packet success probability is higher than 99%, so the protocol can meet the performance requirements of the airborne tactical network effectively.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55574305,"openaccessinfo":{"externalids":{"MAG":"2793425087","ACL":null,"DOI":"10.12783\/dtcse\/wcne2017\/19812","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.12783\/dtcse\/wcne2017\/19812","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"B1-xLaxFeO3 (x = 0.0, 0.025) crystallites were prepared by chemical solution route. XRD analysis confirmed the phase formation of the materials. Thermal characterization was done by DSC-TGA to confirm crystallization and thermal behavior for phase development. Morphological studies by FESEM showed the agglomerated nature of the ferrite and EDX analysis confirmed the degree of doping. FTIR studies were done to determine the molecular signature of both undoped and doped sample.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":138035517,"openaccessinfo":{"externalids":{"MAG":"2341084726","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Argus II epiretinal prosthesis has been developed to provide partial restoration of vision to subjects blinded from outer retinal degenerative disease. To date, the device has been implanted in multiple subjects with profound retinitis pigmentosa as part of a worldwide clinical feasibility study (clinicaltrials.gov ID: NCT00407602). The Argus II is intended to provide partial restoration of functional vision. Most subjects showed an improvement in tasks assessing orientation & mobility, spatial-motor localization, and ability of discerning the direction of motion of moving stimuli. Roughly one third of subjects experienced measurable improvement in visual acuity with the implant. Some subjects identified words with high accuracy, a result that has also been reported by the leading subretinal implant group. Perceptual threshold was correlated with electrode-retina distance, electrode-fovea distance, and light sensitivity, either as single variables or in bivariate linear regression. Taken together these three variables may be used to inform patient selection and develop algorithms for the fitting of higher-electrode count systems. Visual acuity for future generations of the Argus implant may not hit theoretical limitations until arrays hold an excess of several hundreds of electrodes. Nevertheless, preliminary safety and efficacy data are supportive of the development of higher-resolution systems that target macular placement from implant design and surgical perspectives.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110857891,"openaccessinfo":{"externalids":{"MAG":"2189461492","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Along with development of information technology and its important applications in education, the field of Computer Assisted Language Learning (CALL) has developed significantly during the past decades. This study seeks to find the effectiveness of multimedia-based learning materials in improving L2 grammar proficiency of Iranian high school learners and also investigates the attitudes of the learners toward CALL. The sample consists of 116 female high school students in Isfahan. They were divided into three groups (two experimental groups and a control group). The first experimental group was instructed through multimedia-based materials, the second one via combined use of multimedia-based materials and the textbook, while the control group was taught conventionally by means of textbook. The results showed that the use of multimedia-based materials led to higher ability of the learners in English grammar and CALL could be used as an effective instructional method for improving L2 grammar proficiency of the learners. The results of the questionnaire, on the other hand, indicated positive inclination of the learners toward the use of CALL materials in language learning. The outcomes of this study can hopefully open a new way to help EFL learners to develop their L2 proficiency more effectively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220690550,"openaccessinfo":{"externalids":{"MAG":"2775227880","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper introduces the British Library's Flashback project, a proof-of-concept that explored the practical challenges of preserving digital content stored on physical media (magnetic and optical disks) using a sample of content from hybrid collection items dating from between 1980 and 2010. It describes some of the activities undertaken by the project, including: the initial collection profiling and sampling of content, the extraction of content from the disks, and the project team's experiments with identifying and applying preservation approaches to the content, which included both emulation and migration. It concludes with some general observations on the approaches taken and looks forward to the second phase of the project.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":249982352,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The infrared spectral energy distributions (SEDs) of main-sequence galaxies in the early universe (z > 4) is currently unconstrained as infrared continuum observations are time consuming and not feasible for large samples. We present Atacama Large Millimetre Array (ALMA) Band 8 observations of four main-sequence galaxies at z \u223c 5.5 to study their infrared SED shape in detail. Our continuum data (rest-frame 110\u03bcm, close to the peak of infrared emission) allows us to constrain luminosity weighted dust temperatures and total infrared luminosities. With data at longer wavelengths, we measure for the first time the emissivity index at these redshifts to provide more robust estimates of molecular gas masses based on dust continuum. The Band 8 observations of three out of four galaxies can only be reconciled with optically thin emission redward of rest-frame 100 \u03bcm. The derived dust peak temperatures at z \u223c 5.5 (38\u00b18 K) are elevated compared to average local galaxies, however, 5\u221210 K below what would be predicted from an extrapolation of the trend at z < 4. This behaviour can be explained by decreasing dust abundance (or density) towards high redshifts, which would cause the infrared SED at the peak to be more optically thin, making hot dust more visible to the external observer. From the 850\u03bcm dust continuum, we derive molecular gas masses between 1010 and 1011 M and gas fractions (gas over total mass) of 30 \u2212 80% (gas depletion times of 100\u2212 220 Myrs). All in all, our results provide a first measured benchmark SED to interpret future millimetre observations of normal, main-sequence galaxies in the early Universe.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":245829670,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The design and RF characteristics of planar dipole antennas facilitated with coplanar waveguide (CPW) structure on semi-insulated GaAs are performed and confirmed to work in super high frequency (SHF) range. As expected, the fundamental resonant frequency shifts to higher frequency when the length of antenna decreases. Interestingly, the resonant frequencies of antenna are almost unchanged with the variation of antenna width and metal thickness. It is shown experimentally that return loss down to \u221254 dB with a metal thickness of 50 nm is obtainable. Preliminary investigation on design, fabrication, and DC and RF characteristics of the integrated device (planar dipole antenna + Schottky diode) on AlGaAs\/GaAs HEMT structure is presented. From the preliminary direct irradiation experiments using the integrated device, the Schottky diode is not turned on due to weak reception of RF signal by dipole antenna. Further extensive considerations on the polarization of irradiation etc. need to be carried out in order to improve the signal reception. These preliminary results provide a new breakthrough for on-chip electronic device application in nanosystems.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":55746448,"openaccessinfo":{"externalids":{"MAG":"2004106718","ACL":null,"DOI":"10.1088\/1757-899X\/17\/1\/012023","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Barbara Pym's fiction has been viewed as an anthropological approach to the social mores of postwar Britain. In this article, I use one of her last novels, Quartet in Autumn, to sharpen that reading to think through how Pym articulated an aesthetics of decline by trumpeting the dying world of the White English spinster. Quartet fictionalizes the agony of what Ramon Soto-Crespo calls \"decapitalized Whiteness,\" that is, where economic loss and a sense of racial disenfranchisement go hand in hand. The transatlantic desire it satisfied for a world that was lost yet redeemable through good old-fashioned English \"women's\" literature prefigures the nostalgia for a preglobal Britain that has underwritten much of Brexit's affective appeal.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-30":3,"2024-26":1}},"corpusid":237930706,"openaccessinfo":{"externalids":{"MAG":"3172062113","ACL":null,"DOI":"10.3167\/HRRH.2020.470204","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A total number of 137 lymph nodes from 33 patients with a malignant non-Hodgkin lymphoma of B-cell lineage was assessed histologically and immunohistochemically with special reference to the presence or absence of the neoplastic B-cells in the B- and T-cell areas of the lymph nodes as well as inside the post-capillary venules (PCV) of the paracortical areas. The B-cell origin of the lymphomas was confirmed by staining the tissues with an indirect immunoperoxidase technique for the cell surface immunoglobulins. The B-cell areas (cortex and medulla) of the lymph nodes were involved by the lymphoma cells in all studied cases. The T-cell areas (paracortex) were involved in 93.4% of the nodes. Lymphoma cells were encountered inside th PCV in 83.2% of the nodes. Furthermore, fifteen nodes were found where the T-cell area was only partially involved despite the totally involved B-cell areas. The results lend some support to the view that the lymph node involvement by the B-cell neoplasias starts from the B-cell areas. This involvement pattern may be used as an aid in the diagnosis of these lymphomas, and utilized in the study of the circulatory properties of the B-lymphocytes in general.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24523949,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Details of the planning permission and building regulation regimes for flues for biomass and combined heat and power systems (non- domestic)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":113502304,"openaccessinfo":{"externalids":{"MAG":"2414630912","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"UNLABELLED\nThe aim of this study is to verify whether the combination of glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, which is a candidate genetic risk factor for troglitazone-induced liver failure, is common to that for the carbamazepine-induced mild hepatotoxicity.\n\n\nPATIENTS & METHODS\nThe genotypes of GSTM1 and GSTT1, and microsomal epoxide hydrolase-3 and -4, were determined in 192 Japanese epileptics treated with carbamazepine.\n\n\nRESULTS\nThe GSTM1 null (GSTM1-) and GSTT1 null (GSTT1-) genotypes in the subjects were 55.7 and 39.6%, respectively. The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were elevated in 46 (24.0%) and 62 (32.3%) cases, and the mean values were approximately 2.3- and 1.8-times higher than the upper limit of normal levels, respectively. The levels of ALT and AST were significantly higher in GSTM1- than in GSTM1 present (GSTM1+) genotypes (p = 0.007 and 0.004, respectively). The level of ALT was significantly higher in GSTM1-\/T1- than in GSTM1+\/T1- and GSTM1+\/T1+ (p = 0.01 and 0.01, respectively), and that of AST was significantly higher in GSTM1-\/T1- and GSTM1-\/T1+ than in GSTM1+\/T1+ (p = 0.02 and 0.003, respectively). The microsomal epoxide hydrolase genotype did not influence the hepatotoxicity.\n\n\nCONCLUSION\nThese findings suggested that GSTM1- rather than GSTM1-\/T1- was a risk factor for carbamazepine-induced mild hepatotoxicity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24479099,"openaccessinfo":{"externalids":{"MAG":"2022472126","ACL":null,"DOI":"10.2217\/14622416.8.5.435","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present radio follow-up observations carried out with the Karl G. Jansky Very Large Array during the first observing run (O1) of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO). A total of three gravitational-wave triggers were followed-up during the months of O1, from 2015 September to 2016 January. Two of these triggers, GW150914 and GW151226, are binary black hole (BH) merger events of high significance. A third trigger, G194575, was subsequently declared as an event of no interest (i.e., a false alarm). Our observations targeted selected optical transients identified by the intermediate Palomar Transient Factory in the Advanced LIGO error regions of the three triggers, and a limited region of the gravitational-wave localization area of G194575 not accessible to optical telescopes due to Sun constraints, where a possible high-energy transient was identified. No plausible radio counterparts to GW150914 and GW151226 were found, in agreement with expectations for binary BH mergers. We show that combining optical and radio observations is key to identifying contaminating radio sources that may be found in the follow-up of gravitational-wave triggers, such as emission associated with star formation and active galactic nuclei. We discuss our results in the context of the theoretical predictions for radio counterparts to gravitational-wave transients, and describe our future plans for the radio follow-up of Advanced LIGO (and Virgo) triggers.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":11872672,"openaccessinfo":{"externalids":{"MAG":"3102041090","ACL":null,"DOI":"10.3847\/2041-8205\/829\/2\/L28","PubMedCentral":null,"ArXiv":"1608.06518"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Nailfold capillaroscopy (NC) is a noninvasive technique that allows to scan the microcirculation. Tortuosities and isolated hemorrhages have been described in the NC of patients with primary Sj\u00f6gren's syndrome (PSS). In patients with Raynaud's phenomenon (RP) associated with PSS decreased capillary density, greater presence of hemorrhage, enlarged loops and even megacapillaries have been reported. Objectives 1) To identify specific findings in patients with PSS defined according to the American-European criteria of 2002. 2) To assess capillaroscopic differences in patients with PSS with or without RP. 3) To analise if the positive of anti-Ro and\/or anti-La confers a distinct profile in capillaroscopy pattern. 4) To describe whether patients with labial biopsy findings characteristic of PSS have differentiated features in microvascular examination. Methods The multicenter NC group of the Catalan Rheumatology Society (CapiCAT group), conducted 150 NC in patients with Sj\u00f6gren's syndrome, 136 of them were diagnosed of PSS. Mean age was 57.6 years (\u00b112.7), 130 (96%) were women. The mean time since PSS diagnosis was 7.9 years (\u00b16.7). Demographic variables, presence of RP, symptoms of PSS, ANA, reumathoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, treatment and outcome of NC according to CapiCAT group consensus (capillary density, capillary length, tortuosities, capillary diameter - including enlarges loops and megacapilaries -, branching, capillary organisation, pericapillary hemorrhages, capillary thrombosis, areas of capillary loss, subpapillary venous plexus and capillaroscopic pattern) were collected. Results RP was present in 32% of PSS, keratoconjunctivitis sicca in 91% (125\/136) of patients (p<0.001), oral xerosis in 93% (127\/136), skin or genital xerosis in 53% (72\/136). Extraglandular involvement (arthritis, pneumonitis, blood disorders, peripheral neuropathy or CNS involvement) was associated in 47% (65\/136). 75% of PSS were anti-Ro + (102\/136) and 40% (54\/136) anti-La +. In patients with positive anti-Ro and\/or anti-La NC was normal in 53% of cases and nonspecific in 36% (p NS). Lip biopsy was characteristic of PSS in 45\/50 lip biopsies. There were no difference in the findings of NC. NC in patients with PSS were normal in 51% of cases and nonspecific in 34%. Scleroderma pattern was reported in 14 patients. RP associated with PSS had nonspecific capillaroscopy in 40% of cases (p=0.1). The amount of pericapillary hemorrhages (p=0.06) and capillary thrombosis (p=0.2) were not increased in our patients, but more enlarged loops were detected in 48% (18\/37) of cases. Conclusions 1) Patients with positive anti-Ro and\/or anti-La have not a distinct profile in capillaroscopy pattern. 2) Patients with labial biopsy findings characteristic of PSS have not differential features in microvascular examination. 3) In our sample, patients with RP associated with PSS had more enlarged loops, but neither pericapillary hemorrhagesnor capillary thrombosis were observed, as reported in the literature. Disclosure of Interest None Declared","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":76009649,"openaccessinfo":{"externalids":{"MAG":"2315963748","ACL":null,"DOI":"10.1136\/annrheumdis-2012-eular.3188","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Although there has been a large body of research conducted on girl and young women victims of commercial sexual exploitation, boy and young men victims do not receive the same attention. The scant research that exists demonstrates mixed findings on the prevalence of boys and young men as victims of commercial sexual exploitation. For example, some studies find they are not as likely to be victims and others find they are victimized equally, or in some cases, potentially even more so than girls and young women, depending on location. ECPAT published a study in 2013 that revealed a lack of awareness and misclassification of boys as victims and the lack of services available to help them. The purpose of this study is to replicate the ECPAT study and determine what changes might have occurred over the past decade. We consulted with key individuals involved in serving boys and young men and conducted a survey of anti-trafficking service agencies to gather current information on the boys\/young men being referred to them for care, the dynamics of their victimization, their most pressing needs, the services\/programs being offered, and gaps in service in their respective locations. Among other relevant findings, one commonality among the boys and young men served by the responding agencies was a history of sexual abuse. Findings inform service providers and contribute to advocacy efforts and policy recommendations at the local, state, and federal levels.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261430296,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/10538712.2023.2249878","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There are few international companies with a high level of customer interaction from digital platforms. A prime example of this is the Oreo Cookie, which with its combination of ingenuity, smartness, and engagement with consumers, has managing to retain an increasing number of people on its various online platforms, but which has also received a mostly positive reception. This business shows that the opportunity to react to emerging developments and incorporate multiplatform technology enables users to impact new and creative messaging and m in more than 100 years of cookies history. Mondel?z has more than 40 plants worldwide, and its center of excellence for producing chocolate is in Brazil, a country that will export the product to the USA. The Brazilian plant can ship to 10 countries, such as Argentina, the United States, Chile, Morocco, Costa Rica, and Colombia. The company has a presence in more than 800,000 points of sale, and, in a first-year, Oreo chocolate could reach 700,000 of these commercial spaces. The company has adapted to the market not to affect its operation, also the case with the energy reform enacted in the current trends. It includes promoting healthy lifestyles, product innovation, responsibility in advertising issues, and leadership in the communication of balanced diets that include snacks that brought taxes on sweets such as chocolate due to their high caloric content. One of the aspects that characterize a successful brand is the fact that other brands want to ally with it and, through co-branding strategies, launch products that, in a certain way, allow them to leverage their reputation and fame to reposition or reinforce their positioning. These are also the logical benefit of allying with a widely accepted brand in terms of the sales potential and the attractiveness generated in the category by putting a product, a widely recognized label, apart from saying that this rule fulfills in a brand like Oreo. Over time, Oreo has become one of the most famous snacks worldwide that helped create new products. It could either be on its own or from the same alliances; we talked about taking advantage of their cookie's successful concept and knowing how to adapt it to other similar or substitute products. However, beyond all the success that has preceded it today, people's great affection towards this brand includes children to the elderly. Many do not know is that its history contains a certain air of controversy that shows that not everything has been rosy throughout the more than one hundred years it has been on the market. Even so, throughout much of the 20th century and so far into the present, the brand has managed to keep this situation at bay and prevent it from direct impact on its image to the point that many are unaware of this issue. It has become a beloved brand in different places and countries present through very well-executed marketing.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":230629419,"openaccessinfo":{"externalids":{"MAG":"3112721126","ACL":null,"DOI":"10.47119\/ijrp1006511120201575","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.47119\/ijrp1006511120201575","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"One of the reasons for the rapidly expanding use of thoracoscopic surgery as an alternative to thoracotomy, is the excision of peripheral lung nodules. Nodules judged too small or too far from the pleural surface to be seen during thoracoscopy, must be localized beforehand. The aim of this study was to evaluate the feasibility and effectiveness of percutaneous placement of needle hook-wires to locate such nodules before surgery. Under Ct guidance 5 nodules were pre-operatively identified in 4 patients. The thoracoscopic resection of the lesions was done without complication, in 1 patient the operation had to be converted into an open one to dislodge of the wire. CT-guided hook-wire localization is easily and safely performed and permits thoracoscopic resection of lung nodules, which otherwise might be impossible.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27829279,"openaccessinfo":{"externalids":{"MAG":"2411263777","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives The aim of this study was to systematically collate and appraise the available evidence regarding the associations between small, dense low-density lipoprotein (sdLDL) and incident coronary heart disease (CHD), focusing on cholesterol concentration (sdLDL-C) and sdLDL particle characteristics (presence, density, and size). Background Coronary heart disease (CHD) is the leading cause of death worldwide. Small, dense low-density lipoprotein (sdLDL) has been hypothesized to induce atherosclerosis and subsequent coronary heart disease (CHD). However, the etiological relevance of lipoprotein particle size (sdLDL) versus cholesterol content (sdLDL-C) remains unclear. Methods PubMed, MEDLINE, Web of Science, and EMBASE were systematically searched for studies published before February 2020. CHD associations were based on quartile comparisons in eight studies of sdLDL-C and were based on binary categorization in fourteen studies of sdLDL particle size. Reported hazards ratios (HR) and odds ratios (OR) with 95% confidence interval (CI) were standardized and pooled using a random-effects meta-analysis model. Results Data were collated from 21 studies with a total of 30,628 subjects and 5,693 incident CHD events. The average age was 67 years, and 53% were men. Higher sdLDL and sdLDL-C levels were both significantly associated with higher risk of CHD. The pooled estimate for the high vs. low categorization of sdLDL was 1.36 (95% CI: 1.21, 1.52) and 1.07 (95% CI: 1.01, 1.12) for comparing the top quartiles versus the bottom of sdLDL-C. Several studies suggested a dose response relationship. Conclusions The findings show a positive association between sdLDL or sdLDL-C levels and CHD, which is supported by an increasing body of genetic evidence in favor of its causality as an etiological risk factor. Thus, the results support sdLDL and sdLDL-C as a risk marker, but further research is required to establish sdLDL or sdLDL-C as a potential therapeutic marker for incident CHD risk reduction.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2}},"corpusid":226295835,"openaccessinfo":{"externalids":{"MAG":"3102495059","ACL":null,"DOI":"10.1371\/journal.pone.0241993","PubMedCentral":"7652325","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0241993&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The elimination of severe power excursion with significant mechanical-energy release during Core Disruptive Accidents (CDAs) is a key issue for the enhanced safety of Sodium-cooled Fast Reactors (SFRs). In order to prevent the formation of a large-scale molten fuel pool within a reactor core, which is one of factors leading to the severe power excursion during CDAs, Japan Atomic Energy Agency (JAEA) is studying the introduction of Fuel Assembly with Inner Duct Structure (FAIDUS). In the current reference design for FAIDUS, the top end of the inner duct is open whereas the bottom end of the inner duct is closed, and therefore it is expected that the molten fuel will be discharged from a reactor core towards an upper sodium plenum through the inner duct. The objective of the present study is to clarify the fundamental mechanism for upward fuel discharge through the inner duct structure in FAIDUS, and thereby to confirm the effectiveness of FAIDUS.In the previous paper, the possibility of upward discharge of a high-density melt driven by coolant vapor was confirmed by visual observation in the JAEA's out-of-pile experiment, in which molten Wood's metal (density at the room temperature: 8700 kg\/m3, melting point: 352 K) simulating the molten fuel was injected into a coolant channel (equivalent inner diameter: 30 mm, total height: 2 m, fluid content: water) simulating the inner duct structure. In this paper, the mechanism of upward discharge of a high-density melt driven by coolant vapor pressure and\/or flow in this experiment is discussed in terms of the application to reactor conditions. Through this discussion, the following mechanisms were clarified.1) Coolant vapor pressure is built up within the coolant channel after the melt injection. The magnitude of the pressure buildup becomes larger with increase of melt-enthalpy-injection rate which is defined by the product of melt-mass-injection rate into the coolant channel and melt specific enthalpy.2) Following the pressure buildup, the melt is discharged upward being driven by the coolant vapor flow directing towards the top opening end of the coolant channel. The upward discharge mass rate becomes higher with the increase of the magnitude of the pressure buildup and therefore melt-enthalpy-injection rate.From these experimental knowledge, it was suggested that the coolant pressure buildup could act as one of the driving force for the upward discharge of a high-density melt through the inner duct structure in FAIDUS under reactor conditions with higher melt-enthalpy-injection rate than the current experimental condition.Copyright \u00a9 2012 by ASME","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":97729323,"openaccessinfo":{"externalids":{"MAG":"2180239904","ACL":null,"DOI":"10.1115\/ICONE20-POWER2012-54224","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Repeated intraperitoneal injections of crocidolite asbestos fibers induced diffuse malignant mesotheliomas in mice. A series of mesothelial cell lines was isolated from mice at different stages in the development of these tumors. The cell lines isolated from mice with mesotheliomas recapitulated their growth pattern in vivo and were tumorigenic when reinjected into syngeneic mice. Similar to human mesothelial cells, growth of the murine cell lines was stimulated by epidermal growth factor. Reactive mesothelial cells and mesotheliomas expressed the receptor for this growth factor. Crocidolite asbestos fibers have been reported to induce sustained expression of the c-fos and c-jun protooncogenes in rat pleural mesothelial cells in vitro (Heintz et al, Proc. Natl. Acad. Sci. USA 90: 3299-303, 1993). Human malignant mesotheliomas have been shown to express c-fos in situ (Ramael et al, Histol. Histopathol. 10: 639-643, 1995). Two of the cell lines derived from highly invasive murine mesotheliomas overexpressed c-fos and c-jun. This murine model recapitulates the histopathology, growth factor responses, and protooncogene expression of human malignant mesotheliomas.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32348155,"openaccessinfo":{"externalids":{"MAG":"2150696343","ACL":null,"DOI":"10.1177\/019262339702500605","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Currently, agriculture is one of the priority sectors of the Russian economy. In view of the requirements for quality, quantity of products and the presence of specific features of business activities, agricultural producers need government support. The aim of the work was to assess the state support provided for agriculture in Russia, regions of the European North of Russia, and mainly in the Vologda region. It has been proposed, when providing state support, to take into account such areas as the formation of a comfortable environment for work and life in rural areas in order to attract personnel to the industry; in order to consolidate the actions of the state and business, it was proposed to organize \"round tables\" with the participation of persons interested in the development of the industry; Also of interest is the development of a system for acquiring agricultural equipment on the terms of leasing, hiring, and rating due to the poor state of the material and technical base.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":242410912,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.31775\/2305-3100-2019-1-23-31","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.31775\/2305-3100-2019-1-23-31","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Construction industry in the U.S. is one of the top Green House Gas (GHG) emitters. It produced 1.7% of the total U.S. GHG emissions in 2002. These emissions are equivalent to 6% of total U.S. industry related GHG emissions, earning it a third rank on the list of highest emitting industries. However, these numbers represent only a part of the total construction emissions but if we add all the direct and indirect construction emissions from the supply chain of construction projects, the construction emissions would represent up to 54% of the total U.S. emissions. Hence, there is a need to lower emission levels from each and every emitter in the construction supply chain. This research work, defining and addressing the importance of Lean Carbon Supply Chain (LCaSC) for construction projects, develops a subsidy allocation mechanism using a two-stage sequential game to model the Agency's and Contractor's behavior. The subsidy allocation mechanism would enable successful implementation of Green Performance Contracting strategies at a minimum cost.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":3}},"corpusid":167571467,"openaccessinfo":{"externalids":{"MAG":"2232968341","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Audio description (AD) is a modality of audiovisual translation which has awoken social and academic interest in the last three decades. Sex is a traditional taboo topic which has been widely discussed in written and audiovisual translation, but which has not already been studied in depth referred to AD. There are scant book chapters or articles which mention the topic of sex in AD, though. Moreover, other general works on AD stress the need to carry out reception studies in order to consider the users' opinions in the production of AD scripts. In this vein, we designed a reception study based on six scenes of films with high erotic content. We used two styles of AD for each scene: the first commercial ADs comply with the Spanish directives of AD (objectivity, precision, adequate vocabulary and terminology), while the second ADs flout them consciously, using a rude style, vulgar words and more explicit and subjective AD that match the style of the sex scenes.\u00a0 The results of our study show that the users refuse the patronization that is frequently used to audio describe sex scenes, in which omissions and manipulations are often present (Sanz-Moreno, 2017a). On the contrary, in general, the blind and visuallyimpaired audiences interviewed prefer alternative ADs. The importance of the sex scenes in the plot has also been pointed out as something to consider when audio describing the scenes themselves. We have also observed that users do not usually accept euphemisms nor vulgar words or metaphors in the AD of sex, and prefer rather explicit and detailed ADs.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225669304,"openaccessinfo":{"externalids":{"MAG":"3085081472","ACL":null,"DOI":"10.1285\/I22390359V35P295","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Calcium and magnesium are among macroelements, both in plant and animal feeding. Green forage, especially that obtained from legume plants, is their main source in ruminants' feed. The optimum content of those elements in fodder positively affects its quality. The aim of this study was to trace changes in calcium and magnesium content in fodder galega (Galega orientalis) during the vegetation period, depending on the year of cultivation and development phase. The results are based on two field experiments, conducted for the third and seventh year. Samples were taken during the harvest from 1 m of the field during the following development phases: budding, start of blossoming, full bloom, end of blossoming and full ripeness. Subsequently, the samples were dried and ground. Calcium and magnesium were determined by the ICP-AES method following dry mineralisation. Statistical calculations have revealed significant variation in calcium and magnesium content in fodder galega (Galega orientalis), depending on the year of cultivation and development phase. The average calcium content in dry matter of the test plant was equal to 15.57 g kg, while that of magnesium was 2.54 g kg. The largest amounts of calcium and magnesium were found in the leaves of the test plant in the third year of cultivation. Considering different development phases of fodder galega, it can be concluded that the highest level of calcium was determined at the end of the blossoming phase and the highest level of magnesium \u2013 during the full ripeness phase. The average Ca : Mg ratio was equal to 6.12 : 1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":82402782,"openaccessinfo":{"externalids":{"MAG":"985080294","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study is to develop a standard tool for pattern identifications in Korean Medicine for Lung Cancer. The advisor committee for this study was organized by 12 Korean Medicine professors from the Korean Association of Traditional Oncology. The item and structure of instrument were based on review of published literature. We took the consultation twice from the advisor committee and additional advices by e-mail correspondences. We divided the symptoms and signs of lung cancer into 6 pattern identifications. - lung spleen both deficiency (\u80ba\u813e\u5169\u865b), lung kidney both deficiency (\u80ba\u814e\u5169\u865b), dampness phlegm obstructing the lung (\u6fd5\u75f0\u860a\u80ba), qi stagnation blood stasis (\u6c23\u6eef\u8840\u7600), yin deficiency toxin heat (\u9670\u865b\u6bd2\u71b1), and heat toxin accumulation (\u71b1\u6bd2\u860a\u7d50). We obtained the mean weights which reflected the standard deviations from each symptoms of the 6 pattern identifications which were scored on a 5-point scale by 12 experts. We designed the Korean medicine pattern identification tool for lung cancer. It was composed of 57 questions in the question-and-answer format. Though there are some limits that this study is not proved about validity and reliability, the instrument is meaningful and expected to be applied to the subsequent research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":76071155,"openaccessinfo":{"externalids":{"MAG":"2321841443","ACL":null,"DOI":"10.15188\/KJOPP.2014.12.28.6.585","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Greenwood, Arkansas, a city of about 7,700 people in west-central Arkansas, has experienced tremendous growth in population during the past decade. The city has the current capacity to produce 4.55x10 6 L of water daily. De- mand for city water use is expected to exceed 6.82 x10 6 L within the next five years. An additional 2.27x10 6 L per day is needed to augment the current supply. Two abandoned, flooded coal mines located near the city have estimated water storage in excess of 1.97x 10 9 L of water. The water has high concentrations of total dissolved solids (TDS), sulfate, and iron. If a decision is made to use the water, it will require treatment to reduce these constituents to acceptable levels. Designing and constructing a viable wetland for pretreatment of mine water would offer Greenwood an inexpensive, pas- sive method to utilize the water from the coal mines. If the city can use water from the coal mines to augment the present reservoir, the expected savings would exceed twenty million dollars. Integrating this system into the current city park sys- tem and green-space will provide a multi-purpose facility that can be used for recreation, education, and wildlife en- hancement. Terms: Phytoremediation, RAPS System, Iron hydroxide, Anoxic limestone drain, Acid mine drainage.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":6219105,"openaccessinfo":{"externalids":{"MAG":"2049668244","ACL":null,"DOI":"10.2174\/1874829500902010001","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.2174\/1874829500902010001","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Although very dynamic and flexible, Turkish SMEs are less innovative than their European counterparts. The analysis undertaken in this paper allows to assess whether this low level of innovative activities is related to a lack of entrepreneurial behaviour and\/or to the weaknesses of the Turkish innovation system. Exploring a unique firm level survey realized among 50,000 small- and medium-sized enterprises, we seek to evaluate the impact of firms' behaviour and choices in the presence of entrepreneurial, technological, institutional, and market opportunities, in an emerging country context. Our results highlight the importance of policy measures in building innovative capabilities.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":166577992,"openaccessinfo":{"externalids":{"MAG":"1604895964","ACL":null,"DOI":"10.1093\/acprof:oso\/9780199596515.003.0007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Adenosine triphosphate\u2013sensitive potassium channel (KATP) openers protect ischemic myocardium by direct protection of cardiac myocytes, which is thought to be a result of activation of mitochondrial KATP (mKATP). KATP is expressed in skeletal muscle, and the purpose of this study was to determine the effect of the mKATP opener BMS-191095 on infarct size in an isolated gracilis model of ischemia and reperfusion in dogs. The right and left gracilis muscles were isolated in anesthetized dogs except for the artery and vein supplying these muscles (pedicle). BMS-191095 (0.4 mg) or vehicle were infused directly into the artery supplying each gracilis muscle (each animal had one drug-treated and one vehicle-treated muscle). The pedicle was completely occluded for 5 hours followed by 48 hours of reperfusion, after which infarct size was determined. In the vehicle-treated gracilis muscles, significant necrosis was observed (82% \u00b1 3% of gracilis muscle). BMS-191095 significantly reduced the infarct size in the contralateral gracilis muscle (55% \u00b1 6%). Reflow into the gracilis muscle was significantly greater in BMS-191095\u2013treated muscles. BMS-191095 appears to reduce damage in ischemic\/reperfused skeletal muscle, suggesting that mKATP activation is an important protective mechanism in this tissue.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42183971,"openaccessinfo":{"externalids":{"MAG":"2021725707","ACL":null,"DOI":"10.1097\/00005344-200312000-00014","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1097\/00005344-200312000-00014","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The object of this paper is to call attention to some of the chemistry of the methyl alcohol stains in common use for the staining of blood, and to point out the practical value of the study to the general practitioner who makes his own blood examinations. Since Wright's modification is that in most common use, the discussion will be confined to it in the first part of the paper, though the remarks apply equally well to the Hastings modification and to the Harlow stain, which will be taken up in some detail later. None of the polychrome methylene blue and eosin mixtures are stable. They are mixtures of polychrome methylene blue, which is both neutrophilic and basophilic, and of eosin, an oxyphilic stain. The specificity of the stain depends alone on the balanced combination of these two components, and this, in turn, depends on the reaction. Methyl alcohol is","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":71625378,"openaccessinfo":{"externalids":{"MAG":"1989070424","ACL":null,"DOI":"10.1001\/JAMA.1909.25420360024003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Phosphoinositide lipids play a dual role in cell physiology. Specific sets of these molecules are short-lived downstream mediators of growth signals, regulating cell survival and differentiation. In addition, distinct classes of phosphoinositide lipids function as constitutive mediators of membrane traffic and organelle identity. Recent work has provided the first direct evidence that phosphoinositides also play a direct role in linking protein secretion with cell growth and proliferation. This review focuses on SAC1 lipid phosphatase and how this enzyme operates in an evolutionary conserved mechanism to coordinate the secretory capacity of ER and Golgi during cell growth.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23673994,"openaccessinfo":{"externalids":{"MAG":"2090153173","ACL":null,"DOI":"10.1039\/b810979f","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"With the dramatic growth in consumers using Mobile plus Video data and the corresponding increase in IP traffic, more Data Centers are required together with a need to scale the capacity within the Data Centers. Moore's law continues to push advances in CMOS technology enabling the design of larger higher capacity ASICs used to build Switches and Routers in the Data Centers. The cost, power dissipation and face plate optical density challenges are being solved by Silicon Photonics deployed in smaller form factor pluggable optics with a longer term transition to embedded optics. This march towards higher data rates, lower cost and lower power dissipation requires major advances in the cost, volume wafer manufacturing, optical packaging and test for Silicon Photonics based products. The focus of this talk will be on how Cisco is addressing these multiple development and manufacturing challenges as Silicon Photonics based products are released in the market.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":35836111,"openaccessinfo":{"externalids":{"MAG":"2612377050","ACL":null,"DOI":"10.23919\/DATE.2017.7927011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Copper was one of the first metals used widely because the metal is fairly plentiful (among the 25 most abundant elements in the earth's crust) and can be found in its metallic state. In addition, the metal and its alloys have a number of beneficial qualities including ductility, malleability, strength, corrosion resistance, and high thermal and electrical conductivity, combined with an attractive appearance. Copper is also an essential trace nutrient for organisms ranging from bacteria to mammals. \n \n \n \nCopper exhibits a rich coordination chemistry with complexes known in oxidation states ranging from 0 to +4, although the +2 (cupric) and the +1 (cuprous) oxidation states are by far the most common, with +2 predominating. Compounds of copper have found extensive practical usage, including as catalysts in both homogeneous and heterogeneous reactions, as fungicides, pesticides, and wood preservatives, as pigments for paints and glasses, and in the so-called high-temperature superconductors. \n \n \n \nThe coordination numbers and geometries of copper complexes vary with oxidation state. For the spherically symmetric d10 CuI ion, the common geometries are two-coordinate linear, three-coordinate trigonal planar, and four-coordinate tetrahedral. CuI compounds are diamagnetic and colorless, except where color results from charge-transfer bands or a counterion; these complexes are often fairly readily oxidized to CuII compounds. The d9 CuII ion is usually found in a tetragonal coordination environment, with four short equatorial bonds and another one or two longer axial bonds although complexes with other structures are known, including tetrahedral, square planar, and trigonal bipyramidal geometries. Most of the CuII compounds are blue or green because of d\u2013d absorptions in the 600 to 900-nm region; exceptions generally also have charge-transfer bands tailing into the visible, causing a red or brown appearance. CuIII complexes are typically square planar and diamagnetic. \n \n \nKeywords: \n \ncopper; \ncuprate; \ncuprous; \ncupric; \ncuprum; \nmining; \nnutrient; \nrefining","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":93225219,"openaccessinfo":{"externalids":{"MAG":"1938490552","ACL":null,"DOI":"10.1002\/0470862106.IA052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Right aortic arches are rare but non exceptional abnormalities of embryonic aortic system. Sometimes responsible for tracheal or esophageal compression, they may be totally asymptomatic and fortuitously discovered. They have to be preoperatively identified in order to modify the procedure of an eventual mediastinal surgery. In this review, we describe the embryonic events which lead to these anatomical variations and the anatomosurgical classification used to precisely define their type. This anatomical definition is indispensable to adjust the surgical procedure to the consequent modification of anatomical relationships.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43849976,"openaccessinfo":{"externalids":{"MAG":"2412857990","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The Phepane Dome is a circular outcrop of metasedimentary rock within the Eastern Lobe of the Bushveld Complex hypothesized to have formed as a diapir, when underlying wallrock rose into the overlying magma body. Interactions between the metasedimentary rock of the Phepane Dome and the magma of the Bushveld Complex were investigated through measurements of oxygen and lithium isotopic compositions, determination of mineral modes and major-element mineral compositions, cathodoluminescence imaging, and dihedral angle analysis. Evidence from cathodoluminescence imaging and dihedral angle analysis suggest that heat transfer during diapirism caused partial melting and complete recrystallization of the Phepane Dome metasedimentary rock. Oxygen isotope analysis of samples from traverses spanning the contact between metasedimentary and igneous rocks demonstrates that relatively minimal exchange of oxygen (over distance ~4 m) occurred across the contact between the Phepane Dome and the surrounding Bushveld magma. The lithium concentrations and isotopic compositions of metasedimentary rock are significantly different from the associated igneous rocks. Lithium isotope analysis of samples from traverses across the contact demonstrates exchange of Li over somewhat greater distances (~60 m) than oxygen, consistent with evidence that suggests a higher diffusivity of Li than most major elements. Models of oxygen diffusion through intergranular melt and aqueous fluid are used to place maximum constraints on the duration of diffusive exchange across the contact, resulting in estimates ranging from 5 kyr to 5 Myr. These values are consistent with previous estimates of the duration of crystallization of the Bushveld Complex and Phepane diapir development.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":131319168,"openaccessinfo":{"externalids":{"MAG":"2255908621","ACL":null,"DOI":"10.2138\/am-2015-5196","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Determining whether constituent opinion agrees or disagrees with proposed regulation is crucial to improving our understanding of standard-setting practices. However, the constituent feedback mechanisms provided by regulators to constituents results in large-scale unstructured datasets\u2014thus establishing an obstacle in examining differences of opinion between parties. Utilizing publicly available documents of the FASB, this study trains machine-learning models to efficiently and effectively categorize the level of agreement and disagreement on proposed regulation between the regulator and its constituent base. We employ three different approaches\u2014a lexicon-based approach using the dictionary method and two participant-based approaches leveraging human raters (AMT and AS). We find that the machine-learning models demonstrate more accuracy in correctly classifying observations as compared to human raters. Further, the analysis indicates that the machine-learning models using the participant-based approach and the lexicon-based approach achieve similar accuracy in predicting constituent agreement and disagreement with proposed regulation.\n Data Availability: Data available upon request.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":2}},"corpusid":260675424,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2308\/isys-2021-032","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background Drosophila retinal architecture is laid down between 24\u201348 hours after puparium formation, when some of the still uncommitted interommatidial cells (IOCs) are recruited to become secondary and tertiary pigment cells while the remaining ones undergo apoptosis. This choice between survival and death requires the product of the roughest (rst) gene, an immunoglobulin superfamily transmembrane glycoprotein involved in a wide range of developmental processes. Both temporal misexpression of Rst and truncation of the protein intracytoplasmic domain, lead to severe defects in which IOCs either remain mostly undifferentiated and die late and erratically or, instead, differentiate into extra pigment cells. Intriguingly, mutants not expressing wild type protein often have normal or very mild rough eyes. Methodology\/Principal Findings By using quantitative real time PCR to examine rst transcriptional dynamics in the pupal retina, both in wild type and mutant alleles we showed that tightly regulated temporal changes in rst transcriptional rate underlie its proper function during the final steps of eye patterning. Furthermore we demonstrated that the unexpected wild type eye phenotype of mutants with low or no rst expression correlates with an upregulation in the mRNA levels of the rst paralogue kin-of-irre (kirre), which seems able to substitute for rst function in this process, similarly to their role in myoblast fusion. This compensatory upregulation of kirre mRNA levels could be directly induced in wild type pupa upon RNAi-mediated silencing of rst, indicating that expression of both genes is also coordinately regulated in physiological conditions. Conclusions\/Significance These findings suggest a general mechanism by which rst and kirre expression could be fine tuned to optimize their redundant roles during development and provide a clearer picture of how the specification of survival and apoptotic fates by differential cell adhesion during the final steps of retinal morphogenesis in insects are controlled at the transcriptional level.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8601292,"openaccessinfo":{"externalids":{"MAG":"2023011425","ACL":null,"DOI":"10.1371\/journal.pone.0022536","PubMedCentral":"3152562","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0022536&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":": Recently, many unmanned surface vehicles (USVs) have been developed and researched for various fields such as the military, environment, and robotics. In order to perform purpose specific tasks, common autonomous navigation technologies are needed. Obstacle avoidance is important for safe autonomous navigation. This paper describes a vector field histogram+ (VFH+) based obstacle avoidance method that uses the monocular vision of an unmanned surface vehicle. After creating a polar histogram using VFH+, an open space without the histogram is selected in the moving direction. Instead of distance sensor data, monocular vision data are used for make the polar histogram, which includes obstacle information. An object on the water is recognized as an obstacle because this method is for USV. The results of a simulation with sea images showed that we can verify a change in the moving direction according to the position of objects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":63333961,"openaccessinfo":{"externalids":{"MAG":"2561738499","ACL":null,"DOI":"10.5574\/KSOE.2016.30.5.426","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the past decade, the cyber-crime related to mobile devices has increased. Mobile devices, especially the ones running on Android operating system are particularly interesting to malware creators, as the users often keep the biggest amount of personal information on their mobile devices, such as their contacts, social media profiles, emails, and bank accounts. Both dynamic and static malware analysis is necessary to prevent and detect malware, as both techniques have their benefits and shortcomings. In this paper, we propose a deep learning technique that relies on LSTM and encoder-decoder neural network architectures for dynamic malware analysis based on CPU, memory and battery usage. The proposed system is able to detect and notify users about anomalies in system that is likely consequence of malware behaviour. The method was implemented as a part of OWASP Seraphimdroids anti-malware mechanism and notifies users about anomalies on their devices. The method proved to perform with an F1-score of 79.2%.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":204838103,"openaccessinfo":{"externalids":{"MAG":"2981969530","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1910.10660"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Kawasaki disease (KD) mainly manifests as excessive inflammation and vascular endothelial cell injury. This disease generally occurs in children younger than 5 years of age and is more severe in children younger than 12 months. KD affects males and females at a ratio of 1.5:1. Polymorphisms of the rs1625579 locus in the miR-13 gene are associated with schizophrenia susceptibility, and high glucose-induced upregulation of miR-137 in vascular endothelial cells promotes monocyte chemotaxis and inflammatory cytokine secretion in gestational diabetes mellitus. However, researchers have not reported whether rs1625579 is associated with KD susceptibility or onset. Therefore, we investigated the relationship between the miRNA-13 rs1625579 T>G polymorphism and KD susceptibility. Methods TaqMan real-time polymerase chain reaction was applied to determine the genotypes of 532 patients with KD (365 males and 167 females) and 623 control subjects (402 males and 221 females). Results Comparison of all cases with all controls revealed that the rs1625579 T>G polymorphism was not associated with KD susceptibility. However, a subgroup analysis revealed that subjects with the rs1625579 TG\/GG genotypes exhibited a significantly higher onset risk for KD before 12 months of age than carriers of the TT genotype (adjusted age and gender odds ratio=1.99, 95% CI=1.04\u20133.83; P=0.039). Conclusion Our results indicate that the rs1625579 T>G polymorphism confers a risk of early-onset KD in southern Chinese children.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52031804,"openaccessinfo":{"externalids":{"MAG":"2887162988","ACL":null,"DOI":"10.2147\/IDR.S174140","PubMedCentral":"6082322","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The concept of green storage in cluster computing has recently attracted enormous interest among researchers. Consequently, several energy\u2010efficient solutions, such as multi\u2010speed disks and disk spin down methods, have been proposed to conserve power in storage systems and improve disk access. Some researchers have assessed their proposed solutions via simulations, while others have used real\u2010world experiments. Both methods have advantages and disadvantages. Simulations can more swiftly assess the benefits of energy\u2010efficient solutions, but various measurement errors can arise from procedural shortcomings. For instance, many power simulation tools fail to consider how heat increases the power overhead of disk operations. Some researchers claim that their modeling methods reduce the measurement error to 5% in the single disk model. However, the demand for large\u2010scale storage systems is growing rapidly. Traditional power measurement using a single disk model is unsuited to such systems because of their complex storage architecture and the unpredictability of numerous disks. Consequently, a number of studies have conducted real machine experiments to assess the performance of their solutions in terms of power conservation, but such experiments are time consuming. To address this problem, this study proposes an efficient simulation tool called Benchmark Analysis Software for Energy\u2010efficient Solution (BASE), which can accurately estimate disks' power consumption in large\u2010scale storage systems. We evaluate the performance of BASE on real\u2010world traces of Academia Sinica (Taiwan) and Florida International University. BASE incorporates an analytical method for assessing the reliability of energy\u2010efficient solutions. The analytical results demonstrate that the measurement error of BASE is 2.5% lower than that achieved in real\u2010world experiments involving energy\u2010estimation experiments. Moreover, the results of simulations to assess solution reliability are identical to those obtained through real\u2010world experiments. Copyright \u00a9 2015 Copyright \u00a9\u20092015 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":29341314,"openaccessinfo":{"externalids":{"MAG":"1587043036","ACL":null,"DOI":"10.1002\/spe.2323","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Vascular stents influence the post-procedural hemodynamic environment in ways that may encourage restenosis. Understanding how stents influence flow patterns may lead to more hemodynamically compatible stent designs that alleviate thrombus formation and promote endothelialization. This study employed time-resolved Digital Particle Image Velocimetry (DPIV) to compare the hemodynamic performance of two stents in a compliant vessel. The first stent was a rigid insert, representing an extreme compliance mismatch. The second stent was a commercially available nitinol stent with some flexural characteristics. DPIV showed that compliance mismatch promotes the formation of a ring vortex in the vicinity of the stent. Larger compliance mismatch increased both the size and residence time of the ring vortex, and introduced in-flow stagnation points. These results provide detailed quantitative evidence of the hemodynamic effect of stent mechanical properties. Better understanding of these characteristics will provide valuable information for modifying stent design in order to promote long-term patency.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":202689,"openaccessinfo":{"externalids":{"MAG":"1966321897","ACL":null,"DOI":"10.1115\/1.1797904","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"For the first time, electroluminescence detected in the middle and far infrared ranges from silicon carbide nanostructures on silicon, obtained in the framework of the Hall geometry. Silicon carbide on silicon was grown by the method of substitution of atoms on silicon. The electroluminescence from the edge channels of nanostructures is induced due to the longitudinal drain- source current. The electroluminescence spectra obtained in the terahertz frequency range, 3.4, 0.12 THz, arise due to the quantum Faraday effect. Within the framework of the proposed model, the longitudinal current induces a change in the number of magnetic flux quanta in the edge channels, which leads to the appearance of a generation current in the edge channel and, accordingly, to terahertz radiation. Keywords: silicon carbide on silicon, terahertz emission, electroluminescence, nanostructure, quantum Faraday effect.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256434974,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21883\/sc.2022.13.53897.9709","PubMedCentral":null,"ArXiv":"2309.03927"},"license":null,"url":"https:\/\/journals.ioffe.ru\/articles\/viewPDF\/53897","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Observational searches for Intermediate-Mass Black Holes (IMBHs), defined to have masses between 30 and 300,000 solar masses, provide limits which allow up to ten percent of what is presently identified as halo dark matter to be in the form of IMBHs. These concentrate entropy so efficiently that the halo contribution can be bigger than the core supermassive black hole. Formation of IMBHs is briefly discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":987961,"openaccessinfo":{"externalids":{"MAG":"1759057553","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"0905.2535"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In their Editorial to the Special Issue on The Chemistry of Waste Plastics Upcycling, the Guest Editors Adam Guss, George Huber, Carol Lin, Xianzhi Meng, Hugh O'Neill, Arthur Ragauskas, Jia Wang, Yanqin Wang, and Frederik Wurm highlight some of the increasingly urgent efforts being made by chemists to address challenges related to the fate of plastics at the end of, their useful lives and the valorization of plastic waste.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":238356476,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/cssc.202101872","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/cssc.202101872","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Adult neurogenesis is thought to be crucial for preserving cognitive functions, which is tightly controlled by various epigenetic regulators. As the methyltransferase of histone H3K27, the role of Ezh2 in neurogenesis of adult mice and its mechanism of action are largely unknown. Here, we show that Ezh2 is expressed in actively dividing neural stem cells (NSCs)\/progenitor cells as well as mature neurons, but not in quiescent NSCs in the subgranular zone. The deletion of Ezh2 in NSCs\/progenitor cells results in a reduction in progenitor cell proliferation. Furthermore, we found that Ezh2 regulates progenitor cell proliferation by suppressing Pten expression and promoting the activation of Akt-mTOR. Moreover, the loss of Ezh2 in progenitor cells leads to a decrease in the number of neurons, which was observed by long-term tracing. Strikingly, conditional knockout of Ezh2 ultimately results in impairments in spatial learning and memory, contextual fear memory, and pattern separation. Our findings demonstrate the essential role of Ezh2 in the proliferation of progenitor cells, thus providing insight into the molecular mechanisms of adult neurogenesis in preserving cognitive functions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9555258,"openaccessinfo":{"externalids":{"MAG":"1965177877","ACL":null,"DOI":"10.1523\/JNEUROSCI.4129-13.2014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although acoustic waves are the most versatile and widely used physical layer technology for underwater wireless communication networks (UWCNs), they are adversely affected by ambient noise, multipath propagation, and fading. The large propagation delays, low bandwidth, and high bit error rates of the underwater acoustic channel hinder communication as well. These operational limits call for complementary technologies or communication alternatives when the acoustic channel is severely degraded. Magnetic induction (MI) is a promising technique for UWCNs that is not affected by large propagation delays, multipath propagation, and fading. In this paper, the MI communication channel has been modeled. Its propagation characteristics have been compared to the electromagnetic and acoustic communication systems through theoretical analysis and numerical evaluations. The results prove the feasibility of MI communication in underwater environments. The MI waveguide technique is developed to reduce path loss. The communication range between source and destination is considerably extended to hundreds of meters in fresh water due to its superior bit error rate performance.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":9248782,"openaccessinfo":{"externalids":{"MAG":"2067632594","ACL":null,"DOI":"10.1109\/TAP.2012.2194670","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of this study is to determine whether or not there is evidence indicating a significant preference for rail travel over bus, and, if such a preference exists, to learn about the characteristics that affect it and cause it to vary from one situation to another. After a brief review of existing literature, models of choice among alternative travel modes are estimated using revealed preference data and stated preference data. The main conclusion of the study is that there is no evident preference for rail travel over bus when service characteristics are equal, but a bias does arise when rail travel offers a higher quality service. The investigation of the impact of different service characteristics using more advanced demand estimation techniques is suggested as a topic for future research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108098051,"openaccessinfo":{"externalids":{"MAG":"562063127","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This book is the first definitive work in English, an authoritative reference to all the hollies in cultivation, describing many of the more than 800 species, 30 deciduous any 780 evergreen. The book is divided into four parts: the first covers landscaping and orcharding, the second includes botany and morphological characteristics, the third is an encyclopedia of cultivars and species, and the fourth offers techniques on cultivation, hybridization, and propagation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":82498901,"openaccessinfo":{"externalids":{"MAG":"634091785","ACL":null,"DOI":"10.5860\/choice.35-3846","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this article, we reported self-pumped stimulated Brillouin scattering (SBS)-induced fast light in a micro-resonator. The optically induced thermal effect in the micro-resonator will lead to a shift of the dispersion spectrum and make the SBS gain occurred in the anomalous dispersion regime. The group delay could be experimentally optimized from -91.0 microsecond to 2.6 microsecond by changing the modulation frequency in a microsphere with its diameter of 175 \u03bcm. The experimental results will benefit applications utilizing anomalous dispersion such as gyroscope.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52032585,"openaccessinfo":{"externalids":{"MAG":"2805477509","ACL":null,"DOI":"10.1364\/OE.26.015377","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Satisfaction with care is a comprehensive measure that incorporates structure, process, and outcome elements of individual patient's interaction with the healthcare system. Despite the worldwide public health burden of prostate cancer, little is known about predictors of satisfaction with prostate cancer care. Available data has evaluated differences in post\u2010treatment satisfaction by treatment and demographic factors; however, few data exist regarding the contribution of both baseline and post\u2010treatment patient\u2010reported measures on satisfaction with care. We evaluated the relationship of various demographic, clinical, treatment, and patient\u2010reported measures on satisfaction with care. Interestingly, while none of the evaluable demographic, clinical, or treatment parameters were associated with satisfaction, numerous patient\u2010reported parameters were associated with satisfaction with prostate cancer care. Specifically, baseline general health\u2010related quality of life (HRQOL) and change in prostate cancer\u2010specific HRQOL after treatment were associated with satisfaction. Additionally, fear of cancer recurrence was also found to be associated with satisfaction. Taken together, these data may be used, in part, to identify a cohort of patients at\u2010risk for dissatisfaction with prostate cancer care. Identification of such a group may allow for incorporation of these data into treatment counseling and\/or implementing intervention strategies to improve post\u2010treatment satisfaction.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":38786866,"openaccessinfo":{"externalids":{"MAG":"1911449820","ACL":null,"DOI":"10.1111\/j.1464-410X.2012.11423.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper advocates the use of the Augmented Reality (AR) as a gateway to allow humans to become an active part inside the Internet of Things (IoT). This technology mixture changes the IoT from its classical pattern, a network of smart objects intercommunicating mostly without us, to an environment of exchanging information where we detain the power to understand, react and amend our surroundings. The first section is a presentation of the general concepts concerning the IoT and AR. The next sub-chapter will refer to some examples of the combined use of AR and IoT already operational. The third paragraph will present the implementation of a teaching application mixing AR & IoT to obtain a better student's access to information. Concluding remarks, containing the authors' opinion on the future development trends in this field of research, will be added at the end. Key-Words: Augmented Reality, Internet of Things, Education","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2}},"corpusid":219616496,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thienopyridine derivatives such as clopidogrel have been shown to reduce the incidence of death in patients undergoing percutaneous coronary intervention when used in conjunction with aspirin. Recently, a new thienopyridine, prasugrel, significantly reduced the primary endpoint of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke to 9.9% compared to 12.1% for clopidogrel. Prasugrel has been shown to be more efficacious than clopidigrel in reducing ischemic events and stent thrombosis, but does cause more life-threatening bleeding in patients undergoing percutaneous coronary intervention.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9456700,"openaccessinfo":{"externalids":{"MAG":"2126722803","ACL":null,"DOI":"10.3410\/M1-8","PubMedCentral":"2920701","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim. To establish the spatial and temporal variability in yield of corn for grain in the Volyn region in 1965-2017. Methods. Agricultural research, multivariate statistics, cluster analysis, geographic information technology. Results. From 1965 to 2015, the highest yield of corn for grain in the Volyn region was observed in the southern regions, and the lowest yield level was established for the northern regions. According to the peculiarities of the temporal dynamics of corn yields, the administrative regions are classified as allocating spatially homogeneous complexes consistent with the Forest-steppe, Polissia, and the Transitional Zone. The indicators of the dynamics of corn yields in all regions are characterized by a positive asymmetry coefficient, indicating an asymmetric distribution with a shift to the left. The presence of asymmetry indicates the heterogeneity of conditions and the cultivation of corn for grain during the study period and the possibility of identifying qualitatively homogeneous time intervals, that is, for the periodization of the investigated hour interval following the yield indicators of corn for grain. The geography of homogeneous clusters identified based on indicators of the dynamics of grain corn, which to a certain extent corresponds to the physical and geographical zoning of the region, is evidence of the ecological conditionality of corn yield by modes that correlate with factors of physical and geographic heterogeneity of the region. Of the ecological and geographic factors, climatic conditions were the most variable over the corresponding period. From 1965 to 2015, the nature of the dynamics of grain corn yields underwent qualitative transformations, which are the basis for appropriate periodization. Essential markers of the respective periods are the general yield level and the yield trend's general direction. Conclusions. The highest yield of corn for grain in the Volyn region was observed for the administrative districts located in the forest-steppe zone, and the lowest was characteristic for the districts within Polissia. The level of grain corn yields in the region may differ by almost 2.9 times, resulting from the soil's heterogeneity and climatic conditions. The dynamics of the production process in the foreststeppe zone and Polissia are in antiphase: favorable conditions for increasing yields in one geographic zone are accompanied by opposite conditions for the adjacent zone and vice versa. Grain corn yield in 1965\u20132015 showed cyclical dynamics, during which periods with two local maximums were observed: in the ninth decade of the 20th century and the second half of the first decade of the 21st century.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":235193073,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Agricultural corporations have been introduced to increase the productivity of farming via entrepreneurial farm management. There are two main subgroups of agricultural corporations. One is composed of farming association corporations and the other consists of agricultural corporation companies. Major tax incentives for agricultural corporations are as follows:1. Exemption of corporate income tax.2. Exemption of capital gains tax for farmland investment.3. Reduction and exemption of dividend income tax for investors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":168528963,"openaccessinfo":{"externalids":{"MAG":"2475320037","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo investigate the clinical effect of electrical stimulation biofeedback therapy combined with pelvic floor functional exercise on postpartum pelvic organ prolapse.\n\n\nMETHODS\nOne hundred and four patients with postpartum pelvic organ prolapse were randomly divided into two groups. There were 52 patients in the control group who were given pelvic floor function exercise. Another 52 patients in the study group were given electrical stimulation biofeedback therapy combined with pelvic floor functional exercises. The clinical efficacy, pelvic floor pressure (contraction pressure, resting pressure, contraction duration), improvement of pelvic floor prolapse, pelvic floor surface muscle potential, quality of sex life and quality of life (PFIQ-7 score and PFDI-20 score) were compared between the two groups.\n\n\nRESULTS\nAfter the therapy, the total effective rate of the study group was higher than that of the control group (P<0.05). The contraction pressure, resting pressure and vaginal contraction duration of the two groups all increased, and the indexes of the study group were higher than those of the control group (P<0.05). The pelvic floor prolapse degree of the two groups tended to be 0 degrees and I light, and the improvement of the study group was better than that of the control group (P<0.05). The average and maximum average values of the resting stage, endurance test stage and re-resting stage of the two groups all increased, and the fast muscle contraction time, fast muscle relaxation time and variability value all decreased, and the improvement of the study group was better than that of the control group (P<0.05). The scores of sexual satisfaction, sexual anxiety, sexual communication, sexual reaction, sexual attitude and sexual body image of the two groups all increased, and the scores of the study group were higher than those of the control group (P<0.05). The scores of PFIQ-7 and PFDI-20 in the two groups all decreased, and the scores of the study group were lower than those of the control group (P<0.05).\n\n\nCONCLUSION\nElectrical stimulation biofeedback therapy combined with pelvic floor functional exercise has a noticeable curative effect and can significantly alleviate pelvic floor prolapse and improve the sex life and quality of life of patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":236431116,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACTThere is a growing 'energy democracy' (ED) movement which regards the transition to renewable energy as an opportunity for socio-economic transformation, as well as technological innovation. The literature on ED tends to associate greater democratic control of energy systems with increased community control over the means of energy generation and distribution. Nonetheless, this literature often assumes rather than demonstrates that the forms of governance it promotes are more democratic than the status quo. This analysis contributes to the emerging field of ED by assessing the complex and varied ways in which communities in Scotland practise energy governance. By focusing on three key governance processes (decision-making, accountability and dispute resolution), the importance of local contexts for the establishment and negotiation of democratic practices is demonstrated. This local specificity, however, also raises further questions regarding the universal applicability of the ED concept.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":55988021,"openaccessinfo":{"externalids":{"MAG":"2787981957","ACL":null,"DOI":"10.1080\/09644016.2018.1427824","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/09644016.2018.1427824?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"These proceedings present the accepted regular papers and some selected extended abstracts from the 3rd joint DICE-FOPARA workshop, which was held in Prague, Czech Republic on April 6-7, 2019, as a part of ETAPS. The joint workshop provides synergies by combining two complementary communities: \nThe 10th DICE workshop explores the area of Implicit Computational Complexity (ICC), which grew out from several proposals to use logic and formal methods to provide languages for complexity-bounded computation (e.g. Ptime, Logspace computation). It aims at studying the computational complexity of programs without referring to external measuring conditions or a particular machine model, but only by considering language restrictions or logical\/computational principles entailing complexity properties. Several approaches have been explored for that purpose, such as restrictions on primitive recursion and ramification, rewriting systems, linear logic, types and lambda calculus, interpretations of functional and imperative programs. \nThe 6th FOPARA workshop serves as a forum for presenting original research results that are relevant to the analysis of resource (e.g. time, space, energy) consumption by computer programs. The workshop aims to bring together the researchers that work on foundational issues with the researchers that focus more on practical results. Therefore, both theoretical and practical contributions are encouraged. We also encourage papers that combine theory and practice. \nThis third joint DICE-FOPARA workshop at ETAPS 2019 follows the successful experiences of co-location of DICE-FOPARA at ETAPS 2015 in London and ETAPS 2017 in Uppsala.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":199552115,"openaccessinfo":{"externalids":{"MAG":"2967806849","ACL":null,"DOI":"10.4204\/EPTCS.298","PubMedCentral":null,"ArXiv":"1908.04478"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"CrP has many exotic physical properties due to a four-fold degenerate band crossing at the Y point of the Brillouin zone, which is protected by the nonsymmorphic symmetry of the space group. We carried out the heat capacity, electrical and thermal transport measurements on CrP and extracted the electron thermal conductivity. Due to the difference in energy and momentum relaxation time during electron\u2013phonon inelastic scattering, the normalized Lorentz number decreases below about 160 K. Below 25.6 K, the normalized Lorentz number begins to recover, which is due to the dominance of elastic scattering between electrons and defects at low temperatures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259345841,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1674-1056\/acc80c","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The ways in which social order emerges from communication in human networks provides a model from which to draw lessons about the design of computing networks. In particular it provides lessons about the likely behaviour of swarms of intelligent agents. In human societies, cooperation and social order are maintained by a combination of laws that govern behaviour (prescription) and peer group pressure to conform. In this study we use simulations of social networks to show that both prescription and peer pressure are needed to achieve conformity. Our results show that dishonesty increases as social interaction decreases, but strongly interacting societies can promote either dishonesty as well as honesty. However, in a strongly interacting society, even a small degree of enforcement ensures almost universal conformity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":13205374,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The principal building blocks underlying Langkawi's status as a tourist destination and a geopark are its nature and culture. Both these resources provide the platform for Langkawi to grow as a tourist destination since 1980s and receiving the geopark status by GGN and UNESCO in 2007. This paper discusses that while tourism is a commercial enterprise, it has an important role in ensuring Langkawi's natural environment is well-protected, and local communities' cultural traditions safeguarded. Central to this need for protection is 'heritage' - the basic ingredient in sustaining Langkawi as a premier tourism destination. This necessitates the need to view tourism and heritage management as interdependent, as both rely on the same 'heritage resources'. Planning can act as the bridge to connect tourism, whose products are identified for their extrinsic values as tourist attractions, and heritage in which assets are identified for their intrinsic values to a community, state, country and the world.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244455328,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21837\/pm.v1i1.94","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.21837\/pm.v1i1.94","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":": This paper engages with the complex relationship between innovation and human health and the role of regulation in bringing the two together, and, in doing so, facilitating inclusive innovation in emerging economies. After outlining the contested role of regulation, we provide two case studies: regenerative medicine regulation in Argentina, and medical devices regulation in India. While these empirically-based case studies examine different scientific sectors in different jurisdictions and therefore have different contextual foundations, they demonstrate the important link between regulatory policies and the successful promotion of innovation. Through them we challenge the oft-repeated complaint that regulation stifles innovation, demonstrating that both a lack of regulation (Argentina) and poorly conceived regulation (India) are equally damaging to innovation, to actor wellbeing, and, ultimately, to human health. We argue that devising new forms of regulation can facilitate increased innovation and thus improved technological (and economic) competitiveness (ie: social\/regulatory innovation can lead to improved technological\/scientific innovation).","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":264435822,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Children with foreign bodies (FBs) in the lower urinary tract have rarely been reported, and their management remains challenging. This study aimed to describe the characteristics and treatment of FBs in children's lower urinary tract. Methods We retrospectively analyzed the clinical data on lower urinary tract FBs that were removed in our hospital from August 2017 to August 2022, including demographics, location, symptoms, imaging examinations, and treatment. Results Four male patients were enrolled, whose ages ranged from 9 to 13 years, with a mean age of 11 years. The course of the disease ranged from 3\u2005h to 2 weeks. Their imaging characteristics were reviewed and analyzed, and two FBs were located in the bladder and two in the urethra. Mosquito forceps were used to remove an acne needle through the urethra in one case. Cystoscopy was first attempted in three cases, in only one of which was the FB removed successfully under endoscopic minimally invasive surgery. In the remaining two cases, removal via transurethral cystoscopy failed, whereby leading to cystotomy being performed. The FBs comprise a skipping rope, hairpin, magnetic bead, and acne needle. The postoperative recovery was uneventful, and no complications occurred during the follow-up period of 3 to 6 months. Conclusion It is rare for children to have FBs in the lower urinary tract. An early diagnosis, as well as appropriate management of lower urinary tract FBs, can significantly reduce complications. Surgical removal of lower urinary tract FBs can be safe and effective, and relatively better outcomes can be achieved.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":255590029,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fped.2022.1095993","PubMedCentral":"9873356","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1095993\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Glomerular endothelial cell injury plays an important role in the development and progression of diabetic nephropathy (DN). The expression and function of klotho in glomerular endothelial cells remain unclear. Thus, this study aimed to investigate the expression and the functional role of klotho in DN progression in mice and in high glucose (HG)-induced cell injury of human renal glomerular endothelial cells (HRGECs) and the underlying mechanism. In this study, HRGECs were cultured with media containing HG to induce endothelial cell injury and db\/db mice were used as DN model mice. Klotho was overexpressed or knocked down in HRECs to evaluate its role in HG-induced HRGECs injury. klotho-overexpressing adenovirus (rAAV-klotho) was injected into db\/db mice via the tail vein to further validate the protective effect of klotho in DN. Decreased klotho expression was observed in DN patients, DN mice, and HG-exposed HRGECs. Furthermore, klotho overexpression significantly abolished the HG-induced HRGECs injury and activation of Wnt\/\u03b2-catenin pathway and RAAS. In contrast, klotho knockdown exerted the opposite effects. Moreover, klotho attenuated diabetic nephropathy in db\/db mice, which was also associated with inhibition of the Wnt\/\u03b2-catenin pathway and RAAS. In conclusion, klotho attenuates DN in db\/db mice and ameliorates HG-induced injury of HRGECs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73477567,"openaccessinfo":{"externalids":{"MAG":"2915710434","ACL":null,"DOI":"10.1080\/15384101.2019.1580495","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15384101.2019.1580495?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The present study examined lip muscle activity during the speech production of stutterers and fluent speakers to provide information about the nature of stuttering blocks. Depressor Anguli Oris (DAO) and Depressor Labii Inferioris (DLI) were recorded, using hooked-wire electromyography (EMG), in 3 stutterers and 3 nonstutterers during productions of the words \"peek\", \"puck\", and \"pack.\" EMG records indicated that nonstutterers activated DAO prior to DLI for production of the initial\/p\/. Stutterers frequently reversed this sequence of onset, particularly when they stuttered. Results are discussed in terms of mistiming versus anticipatory hypertension hypotheses about stuttering.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33204264,"openaccessinfo":{"externalids":{"MAG":"2014685348","ACL":null,"DOI":"10.1044\/JSHR.3101.28","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a novel coupled inductor based high boost inverter topology which can be utilized in low voltage renewable systems where high voltage step-up is needed to interface with 110 Vt220 V AC systems. The proposed inverter possesses high boost ability with superior EMI immunity compared to a traditional voltage source inverter (VSI). Unlike the traditional VSI, the proposed inverter does not need dead time circuit for its switching signals as it utilizes shoot-through state of the inverter in its single-stage configuration. Insertion of shoot-through state also helps it to achieve high boost operation essential for renewable energy applications. The proposed inverter is derived from Current-Fed Switched Inverter topology. Apart from topology derivation, this paper describes the steady state analysis of the inverter and establishes the relation between input, DC-link, and AC output. An experimental prototype is built to validate the proposed inverter circuit. A 220 V (rms) AC is obtained from 52 V DC input to demonstrate its boost mode of operation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55666417,"openaccessinfo":{"externalids":{"MAG":"2558665481","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Planar, gain-guided vertical-cavity surface-emitting lasers (VCSELs) with a modulation bandwidth of 14 GHz are described. This bandwidth is reached at a drive current of only 8 mA. The intrinsic bandwidth of these devices is estimated to be greater than 50 GHz. Nonlinear light-current characteristics of these lasers may lead to a high level of nonlinear harmonic distortion of the high-frequency output. It is shown that the relative intensity of the second-harmonic response decreases rapidly at higher drive currents, in agreement with a phenomenological model based on the DC characteristics of the laser.<>","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":38423115,"openaccessinfo":{"externalids":{"MAG":"2041201499","ACL":null,"DOI":"10.1109\/68.262540","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A fundamental challenge in the design of Wireless Sensor Network (WSN) is to enhance the network lifetime. The area around the Sink forms a bottleneck zone due to heavy traffic-flow, which limits the network lifetime in WSN. This work attempts to improve the energy efficiency of the bottleneck zone which leads to overall improvement of the network lifetime by considering a duty cycled WSN. An efficient communication paradigm has been adopted in the bottleneck zone by combining duty cycle and network coding. Studies carried out to estimate the upper bounds of the network lifetime by considering (i) duty cycle, (ii) network coding and (iii) combinations of duty cycle and network coding. The sensor nodes in the bottleneck zone are divided into two groups: simple relay sensors and network coder sensors. The relay nodes simply forward the received data, whereas, the network coder nodes transmit using the proposed network coding based algorithm. Energy efficiency of the bottleneck zone increases because more volume of data will be transmitted to the Sink with the same number of transmissions. This in-turn improves the overall lifetime of the network. Performance metrics, namely, packet delivery ratio and packet latency have also been investigated. A detailed theoretical analysis and simulation results have been provided to show the efficacy of the proposed approach.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":9157297,"openaccessinfo":{"externalids":{"MAG":"2094102717","ACL":null,"DOI":"10.1109\/TWC.2012.111412.112124","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"What is certain is that we will age. Demonizing this inevitability hardly encourages people to get on with the distinctive work often possible for the first time only in life's later years. That work calls for the belated recognition and some integration of humanity's enduring ambivalences: we are both angels and animals, both natural creatures and societally nurtured.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36920428,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Biomarkers provide certain values for diagnosis, monitor treatment efficacy, or for the development of novel therapeutic approach for particular diseases. Thus, the identification of specific of biomarkers for specific medical problems, including malignant diseases may be valuable in medical practice. In the study, we have used the Wilms' tumor gene (WT1) as a biomarker to evaluate its expression in local adult patients with newly diagnosed acute leukemia, including both acute myeloid and lymphoid leukemias (AML and ALL). Aim To investigate WT1 gene expression in adult patients with acute leukemia at diagnosis. Methods Eighteen patients with acute leukemia diagnosed at Singapore General Hospital, Singapore, between September, 2004 and July, 2005 were included in this study. There were fifteen AML and three ALL cases aged from 18 to 71 years old. Total RNA and DNA was extracted from peripheral blood mononuclear cells (PBMCs). Expression of WT1 was detected by nested reverse-transcription polymerase chain reaction (Nested RT-PCR). K562, and 3T3 cells were used as positive- and negative-controls. The results were revalidated using real-time PCR. HLA-A genotyping was performed using sequence specific oligonucleotide polymorphism (SSOP) analysis. Results WT1 gene was exclusively expressed in all eighteen, including three ALL and fifteen AML, patients. In contrast with WT1 gene, the HLA-A genotyping was remarkably heterogeneous in these patients. Conclusions WT1 gene expression was observed in local patients with acute leukemia at diagnosis. It may be used as a potential molecular marker for diagnosis, clinical progression of the diseases or monitoring the response to treatment, as well as a target for the development of novel therapeutic approaches.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8751021,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4137\/117727190700200025","PubMedCentral":"2717842","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thermal conductivities of polybutadiene crosslinked with sulfur as a function of the heat flux autocorrelation function by using an equilibrium molecular dynamic (EMD) simulation were investigated. The Green\u2013Kubo method was used to calculate thermal conductivities. All simulations were performed by applying the LAMMPS software (version 3 Mar 2020) package. The united-atom force field (OPLS-UA) from the Moltemplate software (version 2.20.3) was applied in the simulations. The influence of uniform and random distributions of sulfur in polybutadiene on the final value of thermal conductivities was studied by polymeric model structures with similar and variable degrees of crosslinking. The results showed that for identical degrees of crosslinking, the distribution of crosslinkers in the polymeric model structures significantly influenced the final value of thermal conductivity. Moreover, the influence of the crosslinking degree on the final value of thermal conductivity was studied by considering polymeric model structures with different degrees of crosslinking. The results demonstrate that by having a random distribution of sulfur, the thermal conductivity will be enhanced. However, by increasing the degree of crosslinking to the higher percentage in random crosslinked model structures, the value of thermal conductivity drops significantly due to possible higher crystallization of the model structures, which decrease the degree of freedom for phonon contributions.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":258381393,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/polym15092058","PubMedCentral":"10181005","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-4360\/15\/9\/2058\/pdf?version=1683775224","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Chronic tension type headache (CTTH) is the most prevalent headache and is associated with a high socio-economic impact. The exact pathogenesis of CTTH remains unclear. It has been shown CTTH has many similar clinic features with fibromyalgia (FM) and major depression disorder (MDD). Several studies have found some changes of hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes, sex hormones and pro-inflammatory cytokines in FM and MDD. We speculated CTTH has the same changes. Striving to provide new insights into the pathophysiology of CTTH, we designed this trial to address the common and specific aspects of these three disorders in their clinic features and pathophysiological mechanisms, especially from neuroendocrine system and inflammatory pathways. Method: The patients with CTTH, FM and MDD were recruited, and the healthy subjects were selected as controls. The sleep quality, depressive mood and cognitive function of all subjects were evaluated. The serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol, thyrotrophin releasing hormone (TRH), thyroid stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4) , gonadotrophin releasing hormone (GnRH), interleukin-1\u03b2 (IL-1\u03b2) and tumor necrosis factor-\u03b1 (TNF-\u03b1) were detected to find the changes of neuroendocrine system and inflammatory pathways which are believed to be linked with these disorders. Results: Compared with the controls, the HAMD-17 and PSQI scores were significantly higher (Ps<0.001) and the MoCA-C score was significantly lower (P=0.029) in the CTTH, FM and MDD patients. The patients with the CTTH, FM and MDD showed different degrees of damage in spatial and object memories compared to the controls (Ps<0.05). The changes of the HPA and HPT axes, GnRH and pro-inflammatory cytokines in the CTTH, FM and MDD patients were similar. In addition, the serum levels of CRH, cortisol, GnRH, TRH, IL-1\u03b2 and TNF-\u03b1 were significantly higher (P<0.001) while TT3, TT4 were significantly lower (P<0.001) in the CTTH, FM and MDD groups relative to the controls. The FM patients showed lower value in the pituitary level of HPA and HPT axis. Conclusion: The patients with CTTH had similar patterns of memory damage and changes of the HPA and HPT axes, GnRH and pro-inflammatory cytokines with the FM and MDD patients.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":42982789,"openaccessinfo":{"externalids":{"MAG":"2536255815","ACL":null,"DOI":"10.4172\/2167-0501.1000190","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"gamma-Aminobutyric acid transaminase (GABA-Tase; 4-aminobutyrate:2-oxaglutarate aminotransferase, EC 184.108.40.206) immunoreactivity in the rat's cerebellum was studied by light and electron microscopy with indirect immunofluorescence and peroxidase-antiperoxidase methods. Evidence is presented for neuronal and neuroglial compartments of GABA-Tase. Labeled neurons included stellate, basket, Purkinje, and Golgi cells of the cortex and a few large neurons in the deep nuclei. Labeled neuroglia included those surrounding Purkinje cells, their radial fibers in the molecular layer, and astrocytes in the granular layer and deep nuclei. No evidence for sagittal microzonation was found. At the ultrastructural level, GABA-Tase immunoreactive sites were localized to cell surface membranes, intracellular organelles, and the cytoplasmic matrix. GABA-Tase immunoreactivity at synapses could be localized precisely to pre- and postsynaptic membranes in gamma-aminobutyric acid (GABA)-containing as well as non-GABA-containing neurons. Specific label was absent from tissues treated with normal rabbit preimmune sera. GABA-Tase labeling was more intense in tissues from animals anesthetized with ether than with barbiturates and after formaldehyde fixation without glutaraldehyde. Increased GABA-Tase immunoreactivity was observed on treatment with colchicine, GABA with oxamic acid, GABA, harmaline, norepinephrine and glutamate, or diazepam (in order of decreasing effectiveness). Serotonin produced no detectable change, and apomorphine and muscimol decreased the immunoreactivity.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":23386392,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Projected changes in precipitation characteristics around the mid-21st century and end-of-the-century are analyzed using the daily precipitation output of the 3-member ensemble Meteorological Research Institute global ocean-atmosphere coupled general circulation model (MRI-CGCM2) simulations under the Special Report on Emissions Scenarios (SRES) A2 and B2 scenarios. It is found that both the frequency and intensity increase in about 40% of the globe, while both the frequency and intensity decrease in about 20% of the globe. These numbers differ only a few percent from decade to decade of the 21st century and between the A2 and B2 scenarios. Over the rest of the globe (about one third), the precipitation frequency decreases but its intensity increases, suggesting a shift of precipitation distribution toward more intense events by global warming. South China is such a region where the summertime wet-day frequency decreases but the precipitation intensity increases. This is related to increased atmospheric moisture content due to global warming and an intensified and more westwardly extended North Pacific subtropical anticyclone,which may be related with an El Ni(n)o-like mean sea surface temperature change. On the other hand, a decrease in summer precipitation is noted in North China, thus augmenting a south-to-north precipit ation contrast more in the future.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":130466153,"openaccessinfo":{"externalids":{"MAG":"2265695390","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Increasing evidence shows that microbes are important for the protection of human health and the health of other living organisms. At the same time, microbes can cause other organisms to become sick or even die. Through microbe\u2013host interaction, we can understand intuitively the process and mechanism of host infection by microbes. Several methods are developed to predict microbe\u2013host interactions. However, current methods are limited by the cost of interaction verification experiments and accuracy. Therefore, there is still a need for a rapid and accurate method to predict microbe\u2013host interaction. Here, we proposed a novel method based on Integrated Similarity, KATZ measure, and Within and Between Scores (ISKATZWBS) to predict microbe\u2013host interactions. Experimental results show that the proposed method performs well and the AUCs are 0.946, 0.981, 0.954 on the PHI-base, HPIDB, and HMDAD datasets repectively. Compared with other four state-of the-art methods: KATZHMDA, WBSMDA , NGRHMDA and NCPHMDA, the proposed method has higher prediction accuracy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":234812780,"openaccessinfo":{"externalids":{"MAG":"3152571778","ACL":null,"DOI":"10.21203\/RS.3.RS-400365\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The latest generation of partial-response maximum-likelihood data channel, recently made available in the IBM 0664 2 Gbyte 3.5 inch disk drive, are examined, and how well it performs its base operation of extracting data from the disk as well as how well it has begun to put other potential sampling detection advantages into practice is reported. Beyond the data rate improvements over the predecessor channel, this latest offering, referred to as the PRDF channel for its expanded digital filter complexity allows a disk drive to perform self-test and self-diagnostics. The use of self-test capability is described as a tool for obtaining precise equalization over all data areas of the 0664 disk drive. The self-diagnostic aids are discussed as a method of reducing the probability of data loss in a disk drive. >","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1}},"corpusid":111348717,"openaccessinfo":{"externalids":{"MAG":"2152754472","ACL":null,"DOI":"10.1109\/20.281371","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Turkey is affected by the COVID-19 pandemic widely as well as all around the world. There is also a global impact in the field of education. Several precautions were taken for preventing infection from COVID-19 at a minimal level. One of the taken precautions is launching a distance education system (DES). DES started to practice from primary to higher education easily and swiftly. This system is an alternative to the existing education system. However, universities' architecture departments that have theoretical courses besides applied courses, are known that they are hard to put to set, moreover, most of them hesitate to start distance education due to characteristics of architectural education. Architectural education teaches codifying phenomenon, concepts, thoughts visually with the help of symbols and teach to analyse these codes. This tenet involves different processes from a student's former education life. Therefore, to reach the aims of architectural education features' and actualization level of learning is essential. Professional schools give privileged status to systemic, preferably scientific knowledge, and the schools' prevailing epistemology of practice, treats professional competence as the application ok privileged knowledge to instrumental problems of practice. When architectural education is considered as a process to gain essential skills, it can be seen that how active learning is important. It does not seem possible to perform \"active learning\"requirements with the distance education system's existing opportunities and architecture students will perform \"passive learning\"during DES is thought. This study focuses on how DES is made productive for architectural education which started to use due to the COVID-19 pandemic. The main aim of this research is to determine problems of architecture students and instructors related to distance architecture education and offering solutions. Additionally, this research goals to contribute to the limited distance architecture education system. To reach these aims questionnaire forms were constituted toward interviews with both architecture students and instructors and from the literature review. Questionnaires were prepared separately for students and lecturers. This procedure aims to offer an integrated solution by gathering different perspectives of participants. Data of the project were acquired by applying online questionnaires to participants via e-mail. Obtained data were analysed statistically using SPSS 22.0 software. This research will make a remarkable contribution about how active learning at applied courses can be increased during DES at architectural schools by presenting qualitative and quantitative findings. \u00a9 2022 Author(s).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":253560211,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1063\/5.0105286","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1063\/5.0105286","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present a straightforward and efficient method to reduce the mode spacing of a frequency comb based on binary pseudo-random phase modulation of its pulse train. As a proof of concept, we use such a densified comb to perform dual-comb spectroscopy of a long-delay Mach-Zehnder interferometer and a high-quality-factor microresonator with sub-MHz spectral sampling. Since this approach is based on binary phase modulation, it combines all the advantages of other densification techniques: simplicity, single-step implementation, and conservation of the initial comb's power.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36744801,"openaccessinfo":{"externalids":{"MAG":"2345752259","ACL":null,"DOI":"10.1364\/OL.41.002282","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The realization of the International Terrestrial Reference Frame (ITRF) builds upon a combination of results derived from several geodetic space techniques, such as Very Long Baseline Interferometry (VLBI), Satellite and Lunar Laser Ranging (SLR and LLR) or Global Navigation Satellite Systems (GNSS). To combine the different techniques and their results in a meaningful way, co-location sites are important where equipment for several techniques is located reasonably close to each other. The relative geometries (local tie vectors) between the geometric reference points of the different techniques can be derived by terrestrial survey at these co-location sites. Within the Global Geodetic Observing System (GGOS) the requirements in terms of e.g. accuracy and frequency of local survey campaigns have been increased to guarantee that the local tie vectors reach an utmost level of global accuracy. In response to this request we developed a concept to achieve automated and continuous monitoring of radio telescope reference points. This concept was realized and tested in 2012 at the Onsala Space Observatory where an automated monitoring system was installed for a continual determination of the reference point of the 20 m radio telescope. The results confirm that uncertainties on the sub-mm level can be achieved with this approach.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1}},"corpusid":54745553,"openaccessinfo":{"externalids":{"MAG":"141712889","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"How we manage National Parks (protected areas or reserves) for their biodiversity is an issue of current debate. At the centre of this issue is the role of ecological research and its ability to guide reserve management. One may assume that ecological science has sufficient theory and empirical evidence to offer a prescription of how reserves should be managed. I use Royal National Park (Royal NP) as a case study to examine how ecological science should be used to inform biodiversity conservation. Ecological research relating to reserve management can be: i) of generic application to reserve management, ii) specific to the reserve in which it is conducted, and iii) conducted elsewhere but be of relevance due to the circumstances (e.g. species) of another reserve. I outline how such research can be used to inform management actions within Royal NP. I also highlight three big challenges for biodiversity management in Royal NP: i) habitat connectivity, ii) habitat degradation and iii) fire management. A key issue for local managers is finding a mechanism to enable their management to be informed by ecological research in their Park in an ongoing way and to be able to encourage further research. If resolved, Royal NP could provide a model to be used by other protected areas.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":58943734,"openaccessinfo":{"externalids":{"MAG":"1533274710","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In 2008 the University of Melbourne began implementation of the Melbourne Model, its new vision for higher education in Australia. Six broad undergraduate university degrees have been introduced and graduate schools created. Students may now progress from an undergraduate generalist degree, with major, to a professional Masters. Alternatively, graduate lateral entry is available for students to pursue a professional qualification without prior preparation. This acceleration has significant implications for design studio teaching. Students with no design background but with an undergraduate degree are now able to study architecture or landscape architecture in just three years, compared to the previous four-to six-year undergraduate degrees. \n \n \n \nThis article reviews and analyses the outcomes of an 'accretive' design studio (Christie 2002) devised for beginning Masters students which attempts to translate a new mandate of 'acceleration' into design pedagogy. Analysis of student focus groups, together with the work produced, revealed not only the value of the accretive model in delivering a cohesive understanding of the design process and a student engagement that exceeds the outcomes of traditional design studio but also highlights the value of an immediate immersion into a community of practice (Lave & Wenger, 1991). We argue that immersion, as distinct from conventional educational models which position education as 'training' for a future participation in a discipline, is central to any acceleration model, serving to position students as active definers of the discipline rather than passive observers and thereby increasing ownership of their learning experience.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":108948473,"openaccessinfo":{"externalids":{"MAG":"1967930973","ACL":null,"DOI":"10.1111\/J.1476-8070.2009.01624.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"reaction. We make no comment on the effect of paraaminosalicylate on the tubercle bacillus or on the effectiveness of streptomycin. Since para-aminosalicylic acid is found to be of value clinically in the treatment of the exudative type of tuberculous lesion, it might be thought, if our contention is correct, that antihistamines would be of value in the treatment of such lesions (see Addendum). However, antihistamine might be expected to inhibit only histamine effects, whereas para-aminosalicylate, in view of the effect of salicylate compounds on the antigen-antibody reaction and the findings recorded here, might be expected to block a wider variety of effects (Figure I). Antihistamines have","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221983940,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5694\/j.1326-5377.1952.tb84014.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Antireflection (AR) at the interface between the air and incident window material is paramount to boost the performance of photovoltaic devices. 3D nanostructures have attracted tremendous interest to reduce reflection, while the structure is vulnerable to the harsh outdoor environment. Thus the AR film with improved mechanical property is desirable in an industrial application. Herein, a scalable production of flexible AR films is proposed with microsized structures by roll\u2010to\u2010roll imprinting process, which possesses hydrophobic property and much improved robustness. The AR films can be potentially used for a wide range of photovoltaic devices whether based on rigid or flexible substrates. As a demonstration, the AR films are integrated with commercial Si\u2010based triple\u2010junction thin film solar cells. The AR film works as an effective tool to control the light travel path and utilize the light inward more efficiently by exciting hybrid optical modes, which results in a broadband and omnidirectional enhanced performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31966705,"openaccessinfo":{"externalids":{"MAG":"2610761209","ACL":null,"DOI":"10.1002\/advs.201700079","PubMedCentral":"5604369","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1002\/advs.201700079","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"To survive in a world where knowledge is limited, time is pressing, and deep thought is often an unattainable luxury, decision-makers must use bounded rationality. In this precis of Simple heuristics that make us smart, we explore fast and frugal heuristics\u2014simple rules for making decisions with realistic mental resources. These heuristics enable smart choices to be made quickly and with a minimum of information by exploiting the way that information is structured in particular environments. Despite limiting information search and processing, simple heuristics perform comparably to more complex algorithms, particularly when generalizing to new data\u2014simplicity leads to robustness.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":16384333,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Among many properties suggested for action selection mechanisms, one prominent one is the ability to select compromise actions. This paper performs an experimental analysis of compromise behavior in an attempt to determine exactly how much compromise behavior aids an animat. The paper concludes that the ability to select compromise actions in some common cases does provide some additional welfare to the animat, but less than previously postulated","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":168290924,"openaccessinfo":{"externalids":{"MAG":"2546016048","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SETTING\nCases of rifampin-resistant Mycobacterium tuberculosis from the prison population in Madrid and from the general population in Spain.\n\n\nOBJECTIVE\nTo identify the rpoB mutations associated with resistance to rifampin and to investigate rpoB genotyping as an epidemiological marker in rifampin-resistant M. tuberculosis.\n\n\nDESIGN\nTwenty-nine rifampin-resistant clinical isolates of M. tuberculosis, 15 obtained from the prison population in Madrid and 14 from the general population in Spain, were characterized by sequence analysis of the 81-bp core region of the rpoB gene and IS6110 DNA fingerprinting.\n\n\nRESULTS\nAll the isolates had mutations in rpoB, with those in codon 531 accounting for 41% of the total. Twenty-three (79%) isolates were highly resistant to rifampin (minimum inhibitory concentration > or = 64 mg\/L). Nineteen different IS6110 fingerprints were observed: one was shared by seven isolates, one by three, two by two, and 15 were unique. Two IS6110 clusters could be divided into subclusters on the basis of rpoB analysis. Epidemiologic links were identified among patients whose isolates had identical IS6110 patterns and rpoB genotypes, but not between those with identical IS6110 patterns and different rpoB genotypes.\n\n\nCONCLUSION\nCharacterization of rpoB mutations can provide information about susceptibility to rifampin and be a useful epidemiological tool for discrimination of rifampin-resistant strains of M. tuberculosis with identical IS6110 fingerprints.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23009600,"openaccessinfo":{"externalids":{"MAG":"158287919","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The current study assesses hepatic and intestinal glucuronidation, sulfation, and cytochrome P450 (P450) metabolism of raloxifene, quercetin, salbutamol, and troglitazone using different in vitro systems. The fraction metabolized by conjugation and P450 metabolism was estimated in liver and intestine, and the importance of multiple metabolic pathways on accuracy of clearance prediction was assessed. In vitro intrinsic sulfation clearance (CLint, SULT) was determined in human intestinal and hepatic cytosol and compared with hepatic and intestinal microsomal glucuronidation (CLint, UGT) and P450 clearance (CLint, CYP) expressed per gram of tissue. Hepatic and intestinal cytosolic scaling factors of 80.7 mg\/g liver and 18 mg\/g intestine were estimated from published data. Scaled CLint, SULT ranged between 0.7 and 11.4 ml \u00b7 min\u22121 \u00b7 g\u22121 liver and 0.1 and 3.3 ml \u00b7 min\u22121 \u00b7 g\u22121 intestine (salbutamol and quercetin were the extremes). Salbutamol was the only compound with a high extent of sulfation (51 and 28% of total CLint for liver and intestine, respectively) and also significant renal clearance (26\u201357% of observed plasma clearance). In contrast, the clearance of quercetin was largely accounted for by glucuronidation. Drugs metabolized by multiple pathways (raloxifene and troglitazone) demonstrated improved prediction of intravenous clearance using data from all hepatic pathways (44\u201386% of observed clearance) compared with predictions based only on the primary pathway (22\u201336%). The assumption of no intestinal first pass resulted in underprediction of oral clearance for raloxifene, troglitazone, and quercetin (3\u201322% of observed, respectively). Accounting for the intestinal contribution to oral clearance via estimated intestinal availability improved prediction accuracy for raloxifene and troglitazone (within 2.5-fold of observed). Current findings emphasize the importance of both hepatic and intestinal conjugation for in vitro-in vivo extrapolation of metabolic clearance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11090096,"openaccessinfo":{"externalids":{"MAG":"2168098990","ACL":null,"DOI":"10.1124\/dmd.110.036566","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Awareness of the importance of wound assessment and management appears to be increasing, and centres of excellence are emerging. Nurses have a responsibility to provide effective research-based care for patients, but require knowledge and training to do this. Research-based practice is important, but there is a case for more nurses being involved in research in this area. Nurses realise that, where disagreement in wound management arises between themselves and other professions, one way to overcome this is by demonstrating that they are skilled, proficient and knowledgeable practitioners in wound care. In this way, autonomy may be promoted and nurses can continue to push forward the boundaries of wound management, questioning rituals and promoting innovation. Good documentation is also important and the use of a wound assessment tool may assist in this. The challenge now is for nurses to demand adequate training in order to help them become the skilled, proficient and knowledgeable practitioners they strive to be.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34378500,"openaccessinfo":{"externalids":{"MAG":"2296675049","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There are numerous advantages in growing vegetable crops in modern-equipped greenhouses and protected spaces without daylight, compared with the traditional production (open-field), or with the production in ordinary greenhouses. In modern greenhouses, particularly in the glass ones, it is possible to control the climate conditions entirely, plant nutrition, implementation of CO2 and other necessary installations, or automation of production process. That enables all-year round and\/or off-season production, which is increasingly in demand in markets all over the world. It particularly goes for vegetables crops typical of warm season (tomatoes, cucumbers, peppers), but also for those of cool season (lettuce, spinach, radishes, broccoli). The USDA organization has developed a software program, which is titled a Virtual Grower. It helps growers to calculate the heating costs of their greenhouse. The software can be used to predict heating and energy consumption specific for the location, greenhouse design, crop produced, and preferences of management. The software program, and a short video, too, can be downloaded for free from the following Web site: https:\/\/ag.umass.edu\/greenhousefloriculture\/fact-sheets\/virtual-grower-link-to-usda-software. There is a widespread question among the expert circles whether the vegetable crops are going to be \"moved\" to greenhouses due to the large-scale climate changes, and in this sense, what the possibilities are for the vegetable crop production. Therefore, any innovation in science is highly important for future patents that may be applicable in agriculture and consequently in vegetable crop growing practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":263235663,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In CESR the clearance between the beam pipe and the REC (Rare Earth Cobalt) magnet is only 1 mm. The 160 cm beam pipe in this section is sloped and has steps to mask the detector from radiation. During high energy operation the beam pipe temperature increases due to synchrotron radiation, higher order modes power loss and image current, and effects the temperature of the REC magnet via convective and radiative heat transfer. The temperature change is proportional to the beam current. This causes a current dependent change in the REC magnetic field strength, resulting in a betatron tune shift of about \/spl Delta\/Q=0.011\/\/spl deg\/C for each quadrupole. To prevent the temperature changes of the beam pipe in this section, a sensitive temperature control cooling system was developed. The temperature of the beam pipe is stabilized within \/spl plusmn\/0.1\/spl deg\/C. The loss parameter of the sloped pipe and power dissipated by synchrotron radiation was calculated from temperature measurements and used to estimate performance at higher current.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123693345,"openaccessinfo":{"externalids":{"MAG":"2111340890","ACL":null,"DOI":"10.1109\/PAC.1997.753391","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Supply chain network is critical to serving customers, so the most common practices are to determine the number, location, and capacity of facilities. But at the same time, uncertainties and risks must be taken into account in order to control delays. In this context, many optimisation models have been developed to use the results in transportation network and therefore improve the supply chain performance. Models were developed in both routing and zoning\/districting problems, and different cases have been discussed in the literature, such as facility location problems, urban problems, and transportation problems. This paper seeks to review the literature in this area and decompose the models into Mathematical modelling and Geometrical approaches. Distribution is an important part of the supply chain management, it is a process with multiple participants. This characteristic brings a high level of uncertainty. This article therefore presents the distribution process and in particular the design of the transportation network which can include both routing and districting problems.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":246035951,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2201.07161"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim. To investigate the parameters of systolic function in patients with acute Q-wave myocardial infarction (AMI), comparing the results of two-dimensional echocardiography (2D EchoCG), three-dimensional real-time EchoCG (3D EchoCG), and computed tomography (CT) as a verification method. To study the parameters of dyssynchrony, which develops due to mechanic myocardial heterogeneity in AMI patients. Material and methods. In total, 82 patients (61 men and 21 women; mean age 52\u00b121 years) were examined within the first 6 days of AMI. The comparison group, comparable by age and sex, included 65 individuals without clinically manifested cardiovascular pathology. All participants underwent standard examinations, electrocardiography (ECG), 24-hour ECG monitoring, EchoCG, angiography, and CT. Mechanic dyssynchrony was assessed by dispersion of the time to the minimal volume of 16 segments (strain dyssynchrony index, SDI). Results. The difference for end-diastolic volume (EDV; 2D vs. 3D EchoCG and 2D EchoCG vs. CT) was statistically significant (respective p-values 0,014 and p=0,0002 and p=0,3). SDI values in AMI patients were significantly higher than in the comparison group participants (6,8\u00b12,7% vs. 2,9\u00b11,6%; p 5,1, the incidence of clinical complications (pulmonary edema, ventricular fibrillation, high-grade atrioventricular block) was higher by 55% (p <0,005r=0,48). Conclusion. Three-dimensional visualization provides an opportunity to assess systolic function parameters more accurately. SDI values were linked to the number of affected coronary vessels. The significance of the observed differences was related to AMI localization. SDI could be regarded as a determinant of both mechanical myocardial heterogeneity and the risk of clinical and arrhythmic complications in AMI.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":80337081,"openaccessinfo":{"externalids":{"MAG":"2613853023","ACL":null,"DOI":"10.15829\/1560-4071-2012-4-13-17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multi-level urbanization provides us a viewpoint or method to analyze the characteristics and mechanisms of regional development and urban-rural development in China in the transitional period.Analysis of multi-level urbanization lays emphasis on disassembling the process of regional urbanization with different spatial levels,in order to indicate the characteristics and mechanisms of the development of urbanization clearly.Taking Zibo city of Shandong province as an example,the paper provides a theoretical framework of the analysis of multi-level urbanization,including urbanization of trans-city and trans-municipality,that of group cities,that of this locality,and that of local communities.With the framework of multi-level urbanization,it is easy to find out the features of the development of Zibo's urbanization in the transitional period.The authors find that the relationship of consanguinity,location and business,the gap of economic development,the effect of scale,the attraction of county seat,and the forces from bottom to top constitute the driving forces of the development of multi-level urbanization in Zibo.Based on the experience of Zibo,the authors put forward the model of the development of multi-level urbanization,and think that with the development of a market economy in China in the transitional period,we should emphasize the pluralistic concept and the multi-levels of the development of urbanization,for it is more and more difficult to generalize the features of regional urbanization with a single model in the newest period.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":203089452,"openaccessinfo":{"externalids":{"MAG":"2972941242","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This chapter outlines some of the basic features of social research. It introduces students to the notion that social research is a process, helps to clarify the reasons for reearch, and explores the relationship between theory and research. Using the analogy of a voyage, it demonstrates that specific tasks associated with for carrying out social research tend to be ordered, but not always orderly. There are dynamic points of issue that need to be negotiated to move a dissertation project toward completion, or otherwise there is a risk of being blown off course. By understanding what is meant by the research process, and how theory can be used in social research, readers can begin to explore, describe, and explain the human world with greater confidence.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210649121,"openaccessinfo":{"externalids":{"MAG":"2977889779","ACL":null,"DOI":"10.1093\/hepl\/9780198811060.003.0002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, a novel drive method, which is different from the traditional motor drive techniques, for high-speed brushless DC (BLDC) motor is proposed and verified by a series of experiments. It is well known that the BLDC motor can be driven by either pulse-width modulation (PWM) techniques with a constant dc-link voltage or pulse-amplitude modulation (PAM) techniques with an adjustable dc-link voltage. However, to our best knowledge, there is rare study providing a proper drive method for a high-speed BLDC motor with a large power over a wide speed range. Therefore, the detailed theoretical analysis comparison of the PWM control and the PAM control for high-speed BLDC motor is first given. Then, a conclusion that the PAM control is superior to the PWM control at high speed is obtained because of decreasing the commutation delay and high-frequency harmonic wave. Meanwhile, a new high-speed BLDC motor drive method based on the hybrid approach combining PWM and PAM is proposed. Finally, the feasibility and effectiveness of the performance analysis comparison and the new drive method are verified by several experiments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27510536,"openaccessinfo":{"externalids":{"MAG":"2038118954","ACL":null,"DOI":"10.1109\/TPEL.2014.2361752","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nPartial bladder outlet obstruction (PBOO) induces sustained bladder over-distension, leading to ischemia\/reperfusion (I\/R)-related oxidative damage of the urothelium via apoptosis. The present study aimed to investigate the sequential course of apoptosis in the urothelium of rat bladder and identify the changes in apoptosis-related proteins during PBOO and subsequent relief.\u00a0Materials and Methods: The study was conducted using 60 female Sprague-Dawley rats divided into three groups: sham-operated, PBOO only, and PBOO plus subsequent relief. PBOO was induced for 2 weeks, and then the obstruction was relieved by removal of the ligature. The urothelium was assessed by a histological analysis, and expression levels of apoptosis-related proteins were detected by quantitative PCR and immunoblotting.\n\n\nRESULTS\nTerminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells were significantly increased in the PBOO only group when compared with the sham-operated group, and decreased in the PBOO relief group when compared with the PBOO group (P < 0.001). From the quantitative PCR and the western blot analyses, expression of Bax, caspase-3, P38, and Jnk was significantly increased in the PBOO group (P < 0.001). However, expression of Erk, Bcl-2 significantly decreased in the PBOO group (P < 0.001). The expression of Erk and Bcl-2 significantly increased in the PBOO relief group when compared with the PBOO group (P < 0.001). In comparison to the sham-operated group, expression levels of survivin significantly increased in both the PBOO and PBOO plus relief groups (P < 0.001). In addition, the expression levels were significantly different between the PBOO and PBOO plus relief groups (P < 0.001).\n\n\nCONCLUSION\nPBOO induced apoptosis of urothelium is related to alterations in the MAPK signaling pathways and apoptosis-related protein change. These results may also suggest that the pro-survival Erk signaling cascade and the expression survivin are activated in response to ischemic bladder injury and associated with initiation of bladder restoration in PBOO and subsequent relief. However, the mechanism of survivin as anti-apoptotic protein in ischemic bladder injuries remains unclear.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":216029328,"openaccessinfo":{"externalids":{"MAG":"3016796954","ACL":null,"DOI":"10.22037\/uj.v0i0.5799","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dry fruits and nutshells are biological capsules of outstanding toughness and strength with biomimetic potential to boost fiber-reinforced composites and protective structures. The strategies behind the Betholletia excelsa fruit mechanical performance were investigated with C-ring and compression tests. This last test was monitored with shearography and simulated with a finite element model. Microtomography and digital and scanning electron microscopy evaluated crack development. The fruit geometry, the preferential orientation of fibers involved in foam-like sclereid cells, promoted anisotropic properties but efficient energy dissipating mechanisms in different directions. For instance, the mesocarp cut parallel to its latitudinal section sustained higher forces (26.0 \u00b1 2.8 kN) and showed higher deformation and slower crack propagation. The main toughening mechanisms are fiber deflection and fiber bridging and pullout, observed when fiber bundles are orthogonal to the crack path. Additionally, the debonding of fiber bundles oriented parallel to the crack path and intercellular cracks through sclereid and fiber cells created a tortuous path.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264525775,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/biomimetics8070509","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2313-7673\/8\/7\/509\/pdf?version=1698292927","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Despite advances in science and technology, the success rate for the treatment of displaced intracapsular femoral neck fractures in high-energy injuries remains disappointing. The blood supply system in the femoral head of humans does not favor recovery from these fractures. Once these fractures occur, osteonecrosis and nonunion rates may be as high as 30%, even if the newest technique is used. There are some surgical techniques used to supplement internal fixation to reestablish the blood supply in the femoral head, but none have been evidently successful. After analysis of related studies, the author concludes that immediate surgical treatment using improved techniques incorporating the principles of biomechanics can improve the success rate of treatment of these fractures. Using these principles, the fracture site can achieve sufficient stability. Consequently, the blood supply in the femoral head and neck can be reestablished earlier and loss of reduction of fragments during treatment can be minimized. Thus, the chance of full recovery from these complicated fractures can be maximized. In this study, the biomechanical characteristics of these fractures and the principles associated with the surgical techniques used for treating them are reviewed and clarified. Finally, a surgical technique which is ideal from the author's viewpoint is presented. The author believes that the recommended surgical technique may become the best method for treating these complicated fractures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36556569,"openaccessinfo":{"externalids":{"MAG":"18717618","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Koopman operator has become an essential tool for data-driven analysis, prediction and control of complex systems, the main reason being the enormous potential of identifying linear function space representations of nonlinear dynamics from measurements. Until now, the situation where for large-scale systems, we (i) only have access to partial observations (i.e., measurements, as is very common for experimental data) or (ii) deliberately perform coarse graining (for efficiency reasons) has not been treated to its full extent. In this paper, we address the pitfall associated with this situation, that the classical EDMD algorithm does not automatically provide a Koopman operator approximation for the underlying system if we do not carefully select the number of observables. Moreover, we show that symmetries in the system dynamics can be carried over to the Koopman operator, which allows us to massively increase the model efficiency. We also briefly draw a connection to domain decomposition techniques for partial differential equations and present numerical evidence using the Kuramoto--Sivashinsky equation.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":260315978,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2307.15325","PubMedCentral":null,"ArXiv":"2307.15325"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tourism for cities with tourist attractions such as Zanjan can become the most important source of monetization. Provided that proper and comprehensive planning is planned and implemented for it. The concept of social marketing is based on that each organization must first determine the needs, wants and interests of its target markets, then providing those needs and demands more effective than other competitors in a way that welfare of both customers and society are provided. This article investigates the impact of social marketing strategy on the urban tourism growth and economic development with emphasis on the mediating role of trust. This study, in terms of purpose, is application-oriented and is descriptive-correlational in terms of method. The statistical population of the study consist of experts, specialists and students of Tourism science at Zanjan city. The sampling method was random, and the sample size was calculated based on the Cochran formula of 391 people. The data collection tool is the standard questionnaire which validity and reliability were evaluated by experts and Structural Equation Model (SEM) using desired Cronbach's alpha (0.896), respectively. Data were analyzed using pls3 and SPSS software. The results of the study indicated that social marketing with an intensity of \"0.556\" and trust with an intensity of \"0.258\" are effective in the tourism growth and economic development. There is also a meaningful relationship between social marketing and trust.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":254205091,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.14505\/jemt.v13.2(58).13","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Literature on functional data analysis\u00a0 is mainly focused on estimation of individuals curves and characterization of average dynamics. The idea underlying this proposal is to focus attention on other particular features of the distribution of the observed data, moving from mean functions towards functional\u00a0 quantiles. The motivating examples are functional data sets that are collections of high frequency data recorded along time. As quantiles provide information on various aspects of a time series, we propose a modelling framework for the joint estimation of functional quantiles, varying along time, and\u00a0 functional\u00a0 principal components, summarizing\u00a0 some common dynamics shared by the functional quantiles.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":125095294,"openaccessinfo":{"externalids":{"MAG":"2753776097","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since excavation began in 1948, the site of Cosa has become one of our most important sources on Roman colonization, urbanism, and daily life. These excavations illuminate every phase of the site's history, from the Republican and early imperial period, to a medieval castle destroyed in the 14th century.This book includes a narrative account of the history of the town seen in the light of the excavations, as well as the publication of all the medieval finds from the site. Illustrated with 150 figures and plates, including numerous reconstruction drawings and an important sequence of Roman pottery, it will be useful to all those interested in Roman and Medieval archaeology and history.An innovative aspect of this publication is the simultaneous web publication of the site's stratigraphy. In this manner, the detailed site information will be available to specialists and those of the general public who closely follow new directions in Roman archaeology.Elizabeth Fentress is an independent scholar and archaeologist working in Rome. She served as Mellon Professor at the American Academy in Rome between 1996 and 1999.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":190965980,"openaccessinfo":{"externalids":{"MAG":"634072668","ACL":null,"DOI":"10.3998\/mpub.17676","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3998\/mpub.17676","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A simple rotational total skin electron irradiation technique utilising a single large field electron beam is presented. Clinical and technical aspects of the technique are discussed and treatment results for the first 10 patients treated for widespread mycosis fungoides reported. The technique is simple and well tolerated by patients, and can easily be implemented in centres utilising electron beam radiotherapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33158526,"openaccessinfo":{"externalids":{"MAG":"2169667875","ACL":null,"DOI":"10.1259\/0007-1285-57-678-501","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background\nHepatitis C virus (HCV) infection has been associated with increased non-liver-related morbidity and mortality. However, studies have yielded inconsistent results.\n\n\nMethods\nThe incidence of clinical events in human immunodeficiency virus (HIV)\u2013infected HCV-seropositive and incidence density\u2013matched HCV-seronegative participants of the Swiss HIV Cohort Study from August 1994 to December 2014 was studied. We compared (1) HCV-seropositive with HCV-seronegative participants and (2) HCV-viremic with successfully treated nonviremic patients. Poisson regression was used to assess differences between these groups.\n\n\nResults\nWe included 2503 HCV-seropositive participants (540 with spontaneous HCV clearance, 1294 untreated HCV RNA positive, 345 treated with sustained virologic response [SVR], 43 during treatment, and 281 treated without SVR), and 2503 HCV-seronegative controls. After a mean follow-up of 8.2 years, we observed (HCV seropositive and HCV seronegative, respectively) 107 and 18 liver events, 41 and 14 kidney events, 230 and 121 osteoporosis\/fractures, 82 and 94 diabetes mellitus, 114 and 129 cardiovascular events, 119 and 147 non-AIDS malignancies, 162 and 126 Centers for Disease Control and Prevention HIV category B\/C events, 106 and 10 liver-related deaths, and 227 and 218 non-liver-related deaths. Compared with HCV-negative controls, HCV-seropositive participants had an increased risk of liver events (incidence rate ratio [IRR], 6.29 [95% confidence interval {CI}, 3.52\u201311.22]), liver-related death (IRR, 8.24 [95% CI, 3.61\u201318.83]), kidney events (IRR, 2.43 [95% CI, 1.11\u20135.33]), and osteoporosis\/fracture (IRR, 1.43 [95% CI, 1.03\u20132.01]). Among HCV-seropositive individuals, treated participants without SVR vs those with SVR had a higher risk of liver events (IRR, 6.79 [95% CI, 2.33\u201319.81]), liver-related death (IRR, 3.29 [95% CI, 1.35\u20138.05]), and diabetes mellitus (IRR, 4.62 [95% CI, 1.53\u201313.96]). Similar but not statistically significant differences were found between untreated HCV RNA\u2013positive patients and those with SVR.\n\n\nConclusions\nWhile HCV exposure was associated with an increased risk of kidney disease and osteoporosis\/fracture, this risk did not seem to be dependent of persistent HCV RNA. Successful HCV treatment was associated with a lower incidence of liver disease, liver-related death, and diabetes mellitus, whereas the other conditions studied were less affected.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206386749,"openaccessinfo":{"externalids":{"MAG":"2562702266","ACL":null,"DOI":"10.1093\/cid\/ciw809","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/cid\/article-pdf\/64\/4\/490\/13804074\/ciw809.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Plastic pollution in rivers negatively impacts human livelihood and aquatic ecosystems. Monitoring data are crucial for a better understanding of sources, sinks and transport mechanisms of riverine macroplastics. In turn, such understanding is key to develop effective plastic pollution prevention, mitigation, and removal strategies. Riverine plastic is mostly studied through the monitoring of floating plastic and through the quantification of plastic deposited on riverbanks. Existing riverbank plastic measurement methods vary greatly, which complicates direct comparison of data collected with different monitoring strategies. We present a framework to better compare and to aid the design of riverbank plastic monitoring methods, which is based on four common elements distilled from riverbank (plastic) litter monitoring methods currently in use. This framework can be used by scientists and practitioners to find the right trade-offs between the data required to answer specific research questions, and the available resources. Subsequently, we use the framework to suggest effective monitoring strategies for four frequently asked research questions. With this paper, we aim to provide a first step toward harmonization of riverbank plastic litter monitoring efforts.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":224805111,"openaccessinfo":{"externalids":{"MAG":"3093951744","ACL":null,"DOI":"10.3389\/frwa.2020.563791","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frwa.2020.563791\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective: To compare outcomes of critically ill patients transferred from another island compared to those patients with direct admission from Emergency Department to intensive care unit (ICU). Patients and Methods: Retrospective study of prospectively collected data during 8 years. The population studied was all critical adult patients transferred from another island to our hospital and those directly admitted from the Emergency Department. Variables were age, sex, clinical diagnosis (coronary, medical, surgical, or trauma), acute physiology and chronic health evaluation (APACHE) II score at admission, ICU days of stay, days of mechanical ventilation and ICU mortality. Results: During the period of study, 3,115 patients coming from Emergency Department (Group 1) were admitted to our ICU and 138 were transferred from another island (Group 2). No significant statistically differences were found between both groups neither age, sex, APACHE II, ICU days, days of mechanical ventilation, and mortality rate (17.5% versus 20.3%, P = 0.43). The multivariate analysis showed that age, APACHE II score, ICU days of stay, type of patient, and days of mechanical ventilation were independent variables associated with mortality. Conclusions: No differences were found in the global prognosis of the admitted patients transferred from another island compared to those who were admitted directly from the Emergency Department. There is no impact on mortality in transferring a patient in our study population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36925694,"openaccessinfo":{"externalids":{"MAG":"1578009831","ACL":null,"DOI":"10.4103\/2229-5151.158393","PubMedCentral":"4477401","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/europepmc.org\/articles\/pmc4477401","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The question of robot safety become increasingly important as future robots will be required to share their working area with humans in order to achieve a fruitful cooperation. The robot's contribution could be restricted to the laborious and repetitive work, whereas the human acts as a supervisor and handles exceptions. A new safety system has been developed which allows such a close interaction. One module has the task to localize people inside the working area and provide the robot with an appropriate behavior pattern in order to avoid situations endangering the operator. This module uses a camera and computer vision techniques to obtain the location of the operator. The other module of the safety system has to prevent a robot runaway, which can be defined as an unexpected robot motion due to a failure of robot hardware or software. Speech recognition is used as interface between operator and robot. A dedicated robot-control structure has been implemented permitting a fast and safe intervention of the operator by means of the speech system.<>","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":61826528,"openaccessinfo":{"externalids":{"MAG":"2137741744","ACL":null,"DOI":"10.1109\/ROMAN.1992.253891","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose \n \n \n \n \nThe purpose of this study to investigate the synthesis of new Cr(III), Fe(III), Ni(II) and Cu(II) Schiff base complexes by a simple technique (microwave technique). The evaluation of the prepared complexes as pigments as corrosion resistant was also explored. \n \n \n \n \nDesign\/methodology\/approach \n \n \n \n \nThe Schiff base complexes were prepared by using microwave method (green chemistry), and then, the physico-chemical requirements according to standards for the synthesised pigments were investigate. \n \n \n \n \nFindings \n \n \n \n \nThe prepared complexes exhibit good physical, mechanical and corrosion properties as pigments in paint formulations. \n \n \n \n \nResearch limitations\/implications \n \n \n \n \nThe simple technique used for synthesis of metal complex pigments will significantly increase the cost saving for the manufacturing of such pigments category. Also, the used technique is considered a green method (eco-friendly), as there no organic solvent was used. \n \n \n \n \nPractical implications \n \n \n \n \nThe evaluation of the prepared complex pigments as corrosion resistants was also studied. \n \n \n \n \nOriginality\/value \n \n \n \n \nIt is a simple technique, green synthesis (no solvent used) is involved and high yield is obtained.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":204102047,"openaccessinfo":{"externalids":{"MAG":"2289653381","ACL":null,"DOI":"10.1108\/PRT-05-2016-0054","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Adequate information about tourist products and services in a destination can attract tourists and influence performance of tourism business. This study sought to determine the Influence of Marketing Strategies on Performance of Cultural Heritage Tourism in Western Kenya. Descriptive embedded case design and Cross-sectional survey design was adopted for the study. The target population consisted of 6 sites, 18 Focus Group Discussion for respondents, 16 Key informants and 8,014 members of households living within the selected Cultural Heritage sites in Western Kenya. The selected heritage sites were: Kit Mikayi, Crying stone, Sikele Sia Mulia, Thimlich Ohinga, Obama Kogelo Cultural Heritage and Kisumu Museum. A sample size of 357 respondents from 6 heritage sites was sampled for the study using purposive for heritage sites, stratified random sampling for respondents from household heads, and saturated sampling for key informants under the study. Primary data was collected by use of Questionnaires, Focus Group Discussions and Interview Schedule. Quantitative data was analyzed using descriptive and inferential statistical techniques. Statistical tests, Pearson product-moment of correlation were used to investigate the relationship between independent and dependent variables. Statistical package for social sciences (SPSS) version 20 was used to analyze data. Hypothesis was tested at 95% confidence level ( \u03b1 = 0.05). Qualitative data was analyzed using thematic framework.\u00a0 The findings of the present study indicated that marketing strategies improved social economic performance of Cultural Heritage Tourism in Western Kenya. Marketing strategies have not been fully exploited in Cultural Heritage sites in Western Kenya. Traditional Marketing Strategies were frequently used than non-traditional marketing strategies to attract potential tourists. The study recommended that both traditional and non-traditional marketing strategies should be employed to reach potential tourists in order to make Cultural Heritage sites in Western Kenya more competitive locally and globally. The Cultural heritage sites should be rebranded and upgraded to make them more attractive and competitive. The Kenya Tourism Board in collaboration with other stakeholders should aggressively market cultural heritage tourism. Keywords : Marketing strategies, Cultural Heritage Tourism, Performance, Tourist products and services, Destination, Western Kenya","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55854109,"openaccessinfo":{"externalids":{"MAG":"2619902151","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Philippines has made significant progress in empowering women and in advancing gender equality. The government's policy on gender equality and women's empowerment has prioritized women's economic empowerment, advancing human rights and enhancing gender-responsive local governance. All these priority concerns are integral components of poverty reduction programs in the Philippines. The Philippines has made significant progress in empowering women and in advancing gender equality. Since the government introduced a constitution in 1987 affirming the equality of women, it has pursued a number of initiatives to mainstream gender concerns in national policies and programs. A development plan for women was launched in 1987, followed by a plan for gender-responsive development, 1995-2025, coordinated by the National Commission on the Role of Filipino women. In 2004, the commission drafted a framework plan for women that identify three priority concerns to meet the objectives of gender equality and women's empowerment: economic empowerment of women, protection and fulfillment of women's human rights, and gender-responsive governance. Projects that support these priorities will facilitate more equitable development across the Philippines, including supporting the full participation of women in political processes and governance in the international and national local level, strengthening gender-sensitive and inclusive programs and mechanisms with civil society, and increasing women's access to economic resources such as capital, technology, information, markets, and training.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":150845327,"openaccessinfo":{"externalids":{"MAG":"59174197","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Arylamine N-acetyltransferases (NATs) are polymorphic enzymes involved in the metabolism of arylamine and hydrazine xenobiotics. Murine NAT isoenzymes are encoded by three Nat genes. Only Nat2 was previously known to be polymorphic, a single nucleotide substitution causing the slow acetylator phenotype in the A\/J strain. The present study (Chapter 3) describes novel polymorphisms in all three Nat genes of the wild-derived inbred strains Mus spretus and Mus musculus castaneus . Functional analysis of hepatic and heterologously expressed NAT variants from the two strains demonstrated that M. m. castaneus is a fast and M. spretus a slow acetylator. A previously isolated 14.3kb Nat -positive mouse genomic clone of 129\/Ola strain origin (clone A) was sequenced (Chapter 4). A 8.6kb Hind III fragment, containing the entire Nat2 coding region, was subcloned from clone A and used to generate a targeting construct for the production of Nat2 knock-out mice. Probes and appropriate PCR methodologies were developed for screening of embryonic stem cells for targeted incorporation of the construct (Chapter 4). Computational analysis of clone A sequence revealed a number of important elements around the Nat2 gene, including four microsatellite markers which were found to be polymorphic among different mouse strains. Combined with preliminary physical mapping work (Chapter 4), these markers will assist accurate localisation of the Nat genes on mouse chromosome 8. A non-coding exon was mapped 6.4-6.1kb upstream of the intronless Nat2 coding region. A functional polyadenylation signal was also identified 0.45kb downstream of the mouse Nat2 coding region. The genomic structure of other genes for mammalian NAT was also analysed, by comparison of ESTs and genomic sequences deposited in electronic databases. Reverse transcription PCR confirmed that Nat2 is expressed in many tissues, while Nat1 and Nat3 are expressed in the liver and spleen, respectively. The Nat2 transcript was also detected in mouse embryonic stem cells, suggesting a possible involvement of murine NAT2 early in development (Chapter 5). The elements constituting the core promoter of Nat2 were characterised, and a preliminary search for other transcriptional regulatory sequences was carried out, using reporter gene assays and electrophoretic mobility shift assays (Chapter 6).","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":82299759,"openaccessinfo":{"externalids":{"MAG":"631213424","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In today's world, the energy demand is skyrocketing and conventional, non-renewable resources are being consumed at a very high rate. Fossil fuels like coal and petroleum are predicted to exhaust in a few years from now. Apart from that burning fossil fuels have disadvantages such as they influence climatic change and global warming and they cause serious health issues (like respiratory illness, heart disease, and asthma) when exposed frequently. Most of the energy requirements of the world are met by non-renewable resources. The world is becoming aware of the situation and opting for sustainable energy options. Hence sustainable options are the need of the hour. The idea of the generation of electricity from microbes is what I call the TAP technology. Waste water is a repository of microorganisms. We could use the internal machinery of these organisms to produce electricity. The metabolism of the microorganisms involves breaking down of complex organic matter such as sugars to produce electrons, as shown below. C12H22O11 + 13H2O \u2192 12CO2 + 48H+ + 48e\u2212 The electrons produced help conduct electricity with an appropriate setup. A TAP plant has two compartments. One compartment holds the wastewater and the other contains copper sulfate solution (or any salt solution). The wastewater compartment is the anode since it is where the oxidation takes place and electrons are transferred to the carbon electrode. The compartment containing copper sulfate solution is the cathode. A copper electrode installed in this compartment. In order to complete the circuit, a salt bridge is required. However, in large-scale implementation of TAP technology, a semi-permeable membrane can be used. A TAP plant set up is similar to a galvanic cell. The conduction of electricity is due to potential difference created across the electrodes dipped in each of the compartments in the TAP plant. TAP technology not only produces electricity but also cleans the wastewater. In the process of electricity generation; the microorganisms die resulting in the purification of water. TAP technology coupled with wastewater treatment plants can prove to be highly efficient. TAP is a great solution to the energy problem the world faces","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":117152379,"openaccessinfo":{"externalids":{"MAG":"2744438105","ACL":null,"DOI":"10.18260\/1-2--27725","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/peer.asee.org\/27725.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"During the 2011-12 school year, nearly 3.5 million public school students were suspended out-of-school at least once. This report examines data on out-of-school suspension rates in every school district in the country and also examines on data on out-of-school suspension rates at the state and national levels. It documents disparities in the use of out-of-school suspension experienced by students with disabilities, and those from historically disadvantaged racial, ethnic, and gender subgroups. At the district level, on average more than one in every ten elementary students and at least one out of every four secondary students enrolled were suspended in 2011-12. Nationally, suspension rates are three to four times higher at the secondary level than at the elementary level. An examination of the racial and gender disparities among secondary students with disabilities shows that males, and most often Black males (33.8%), have the highest risk for suspension, followed by Latino males (23.2%). Also important to note is that Black females with disabilities are suspended at higher rates than White males with disabilities\u201422.5% and 16.2%, respectively. These disparities extend beyond the vast loss of instruction time experienced by students who are suspended. A school or school district's excessive use of exclusionary discipline raises alarms because of the negative impact high suspension rates have on graduation rates, the learning environment, and rates of juvenile crime and delinquency in the larger community. Suggestions for remedies are also detailed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":151114876,"openaccessinfo":{"externalids":{"MAG":"292973241","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In order to maximize science returns in radio astronomy there is a constant drive to process ever wider instantaneous bandwidths. A key function of a radio telescope signal processing system is to divide a wide input bandwidth into a number of narrow sub-bands for further processing and analysis. The polyphase filter-bank channelizer has become the primary technique for performing this function due to its flexibility and suitability for very efficient implementation in FPGA hardware. Furthermore, oversampling polyphase filter-banks are gaining popularity in this role due to their ability to reduce spectral image components in each sub-band to very low levels for a given prototype filter response. A characteristic of the oversampling operation in a polyphase filterbank, however, is that the resulting sub-band outputs are in general no longer band centered on DC (as is the case for a maximally decimated filterbank) but are shifted by an amount that depends on the index of the sub-band. In this paper we present the structure of the oversampled polyphase filterbank used for the new Australian Square Kilometer Array Pathfinder (ASKAP) radio telescope and describe a technique used to correct for the sub-band frequency shift brought about by oversampling.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":12040185,"openaccessinfo":{"externalids":{"MAG":"2218762913","ACL":null,"DOI":"10.1109\/DSP-SPE.2015.7369562","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Uca tangeri is a marine fiddler crab found commonly in the West African coast and is often exposed to Gram-negative pathogens upon injury. The aim of this study was to document the patterns of endotoxin-induced protein coagulation and phenoloxidase (PO) activity in hemolymph fractions of Uca tangeri. Hemolymph from live crabs was obtained by carapace puncture, pooled. and then separated into plasma, hemocyte Lysate (HL), hemocyte lysate supernatant (HLS) and hemocyte lysate debris (HLD). The effect of Escherichia coli (O1111:B4) endotoxin and calcium ion (Ca2+) on protein coagulation in the presence\/absence of endotoxin and the endotoxin dose-dependence of coagulation and PO activity were each studied in the plasma, HL, HLS and HLD. The results showed Ca2+ was required to induce coagulation, and was endotoxin concentration-dependent in the plasma. PO activity was highest in the HLS but PO specific activity was highest in HLD. PO activity remained relatively constant with increased LPS concentration in the range studied 0\u201310 EU\/ml. From the data we conclude that endotoxin-induced protein coagulation occurs in the plasma alone and might be mediated by trans-glutaminases, while PO activity is localized inside hemocytes and cell membranes in Uca tangeri.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6266662,"openaccessinfo":{"externalids":{"MAG":"2290076389","ACL":null,"DOI":"10.3109\/1547691X.2015.1096983","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The cognitive semantic research into spatial prepositions has focused on their polysemous nature and the coherence of cognitive categories they constitute. At thesame time, the question of their categorical status has not yet been resolved causing disagreement about their membership in the content or function word group. The presentcorpus-based study investigates the semantic structure of the English spatial preposition at regarded as a typically English preposition not present in other languages. The investigation attempts to establish the primary sense of the preposition and to find motivating principles behind the individual senses. For the purpose of the study, 2168 linguistic items extracted from the British National Corpus and containing the preposition were analyzed yielding 18 distinct senses and one group of miscellaneous expressions. The research suggests that the semantic structure of the preposition at is best seen as a semantic network with the primary sense functioning as a prototype and other related senses as more peripheral extensions. The research reveals that the polysemy of the preposition at\u00a0is relatively extensive and that the word at does not belong to morphological categories other than the prepositional one.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":67259948,"openaccessinfo":{"externalids":{"MAG":"2615067609","ACL":null,"DOI":"10.18276\/AN.2015.9-02","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper aims at investigating the performance and emissions of a diesel engine using bio oil emulsions obtained from Prosopis Juliflora as fuel. Emulsions of PJSO (Prosopis Juliflora Seed Oil) namely PJSO5, PJSO10, PJSSO15 and PJSO20 were prepared by mixing respectively 5%, 10%, 15% and 20% of the PJSO with 92%, 87%, 82% and 77% of diesel by volume in the presence of 3% of a surfactant (span 80). Fuels were tested in a mono cylinder diesel engine for their performance as fuel. Engine test results showed comparable performance for all the emulsions of PJSO with BD (base diesel). At the maximum power output the brake thermal efficiency was found as 30.1%, 29.6%, 28.8% and 28% respectively with PJSO5, PJSO10, PJSO15 and PJSVSO20 where as it was 30.5% with BD. There is a considerable reduction in smoke and NOx emissions with the emulsions of PJSO as compared to BD at all power outputs. It was concluded that PJSO obtained from Prosopis Juliflora can be used upto 15% by volume as partial replacement of diesel by making emulsions with comparable performance with diesel. To use PJSO as soul fuel, the fuel and engine need further modifications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110523261,"openaccessinfo":{"externalids":{"MAG":"2183879205","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aimed to discover the correlation between patient satisfaction with nursing care activities and staffing patterns. The research was conducted at the medical ward of a secondary care regional hospital in Slovenia over one month. Data was collected with regard to the following: (1) patients cared for daily and number of hours\/patients day at the ward level, (2) patient needs (using a classification system), (3) nurse activities as observed at 10-minute intervals, and (4) the Patient Perception of Hospital Experience with Nursing tool. A total of 218 patients were involved, and their satisfaction with nursing care was found to be high. Patient satisfaction was negatively correlated with the number of patients cared for at the unit daily, but positively with the number of care hours per patient day, the proportion of registered nurses in the nursing team, the realized percentage of the registered nurse personnel requirements, and with some direct care activities. The correlation also revealed three process items (undivided attention, explanation, and things are done without asking) being the special strengths of nursing care activities. The results show that nurse-staffing and process patterns affect patient experience. It is thus recommended to increase the amount of nursing care offered by registered nurses, while nurses' competences can affect the process of care, and thus patient satisfaction.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233841082,"openaccessinfo":{"externalids":{"MAG":"3135109401","ACL":null,"DOI":"10.5772\/INTECHOPEN.96589","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since the kinetic energy is dissipated through plastic deformation energy generated in expanding process of the tube by a die. In order to successfully absorb the kinetic energy there should be no buckling in the expansion tube during expanding process. The buckling instability of the expansion tubes is affected by the initial boundary conditions, tube thickness and length. In this study, the effects of the tube thickness except length and initial boundary condition on the buckling instability are studied using a finite element method. In addition, Analysis procedure for nonlinear post-buckling analysis of expansion tube is established. There are three kinds of finite element analysis procedures for buckling analysis of expansion tube, quasi-static analysis, linear buckling analysis and nonlinear post-buckling analysis. The effect of the geometry imperfections defined as linear superimposition of buckling modes is considered in the nonlinear post-buckling analysis. The results of finite element analysis indicate that the buckling load increase with increase of thickness of tube and geometry imperfection. Finial buckling shapes are changed with respect to the geometry imperfection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137171014,"openaccessinfo":{"externalids":{"MAG":"319129852","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"States in the arid U.S. West, where average annual precipitation is below 20 inches, have experienced ongoing water scarcity in part due to prolonged spells of drought. Most western states rely on the doctrine of prior appropriation based on the seniority of rights to allocate water across individuals. Over the past two decades, states have established water supply banks and rental pools to facilitate the transfer of water among users on a season-to-season basis, which, in many cases constitutes a hybrid system that marks a movement towards a market-based system of allocating water but retains many of the features of current water rights institutions. The study delineates the importance of these banks in alleviating short term water scarcities when water use may be curtailed based on priority dates. It finds that under severe drought conditions, water banks may approximate the efficiency gains from a fully efficient water allocation scenario but may not prevent the large scale diversions by senior users.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":127928926,"openaccessinfo":{"externalids":{"MAG":"600303805","ACL":null,"DOI":"10.22004\/AG.ECON.150643","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The research aims to determine the best dose of Urea to yield and seed quality in some varieties of sorghum. This research using a randomized block design consisting of two factors with 3 replications. The first factor was 4 varieties of sorghum those Kawali, Numbu, Pahat and Mandau and the second factor was 3 levels of Urea treatments (60, 120 and 180 kg Urea\/ha). Parameter those observed were seed weight\/m 2 , weight of 1000 seeds, first count test, standard germinator test, index value test and seedling growth rate. The mean separation of analysis of variance was tested using Duncan's multiple range test at 5%. The result indicates that application of 60 kg Urea\/ha gave the best result on Pahat and Kawali. Application of 120 kg Urea\/ha and 180 kg Urea\/ha on Pahat gave the best result compare to Kawali, Numbu and Mandau. Varieties Kawali and Mandau gives the best in seed quality on Urea treatments at a dosage of 120 kg Urea\/ha.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":93512061,"openaccessinfo":{"externalids":{"MAG":"2372096423","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The rat race between user-generated data and data-processing systems is currently won by data. The increased use of machine learning leads to further increase in processing requirements, while data volume keeps growing. To win the race, machine learning needs to be applied to the data as it goes through the network. In-network classification of data can reduce the load on servers, reduce response time and increase scalability. In this paper, we introduce IIsy, implementing machine learning classification models in a hybrid fashion using off-the-shelf network devices. IIsy targets three main challenges of in-network classification: (i) mapping classification models to network devices (ii) extracting the required features and (iii) addressing resource and functionality constraints. IIsy supports a range of traditional and ensemble machine learning models, scaling independently of the number of stages in a switch pipeline. Moreover, we demonstrate the use of IIsy for hybrid classification, where a small model is implemented on a switch and a large model at the backend, achieving near optimal classification results, while significantly reducing latency and load on the servers.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-26":1}},"corpusid":248834033,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2205.08243","PubMedCentral":null,"ArXiv":"2205.08243"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"By declaring an item legal tender or making it publicly receivable, governments might generate sufficient demand to determine the medium of exchange. How do private actors launch a new money? There are two views in the literature. The first requires offering an item with a use value to some agents that is distinct from its role as a medium of exchange. The second suggests that agents might coordinate on an intrinsically useless item. With these views in mind, I survey the logs from the original bitcoin forum, bitcoin-list. I find that early participants in the bitcoin community understood the importance of coordination and took steps to coordinate users.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":158579444,"openaccessinfo":{"externalids":{"MAG":"2752261798","ACL":null,"DOI":"10.2139\/ssrn.3014456","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Hand preferences in 26 capuchin monkeys (Cebus apelld) were examined in 2 reaching-forfood tasks under 2 postural conditions. In the 1st task (unimanual), monkeys were required to reach for food from both a quadrupedal and an upright posture. A right-hand bias was found for the upright but not for the quadrupedal condition. In the 2nd task (coordinated bimanual), monkeys were required to extract the food from a hanging Plexiglas tube from both a crouched and an upright posture. A right-hand bias was found for both conditions. A significant increase in right-hand use was noted from the unimanual, quadrupedal, reaching task to the coordinated-bimanual task, with females exhibiting a greater right-hand preference than males. In addition, a significant effect of task complexity on strength in laterality was found. Results are discussed in the context of recent theories on primate laterality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":143322816,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1037\/\/0735-7036.112.2.183","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Physics explores a universe of wonderful order, expressed in terms of beautiful mathematical equations. Mathematics itself is understood to be the exploration of a realm of noetic reality. Science describes matter in terms of concepts with mind-like qualities. The psychosomatic nature of human persons is best understood in terms of a dual-aspect monism, in which matter and mind are complementary aspects of a unitary being. The new science of complexity theory, with its dualities of parts\/whole and energy\/information, offers modest resources for the speculative exploration of this idea. The intrinsic unpredictabilities present in nature afford the metaphysical opportunity to consider dissipative systems as exhibiting top\u2013down causality.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":170708517,"openaccessinfo":{"externalids":{"MAG":"1985777346","ACL":null,"DOI":"10.1111\/J.1467-9205.2008.01365.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes the act of subvertising in Turkey with a focus on a recent anti-consumerist campaign led by activists against a national brand. The act of subvertising has been evaluated as a critical activism under the general label of \"culture jamming\", which aims to challenge the hegemonic meanings conveyed by media messages. Particularly, advertising and branding have been the facilities that were targeted by culture jammers and advertisers due to their potentials of carrying out hegemonic discourses of class, gender and ethnicity. With an analysis of a recent advertising campaign by Do\u011fadan, an herbal tea company that caused the outrage of women due to the sexist messages that it conveys, this paper will draw attention to the ways in which subvertising is establishing itself as a critical practice in Turkey's contemporary visual landscape. Keywords\u2014advertising, subvertising, Turkey, visual culture, branding, gender, culture jamming.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":181867816,"openaccessinfo":{"externalids":{"MAG":"2793126385","ACL":null,"DOI":"10.15224\/978-1-63248-103-0-51","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.15224\/978-1-63248-103-0-51","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Hydrocephalus is a condition in which cerebrospinal fluid accumulates in the section \nof the brain called ventricle in much larger volumes than normal, causing the ventricle \nto be enlarged and the brain to be under pressure. Many of the children with \nhydrocephal us receive a surgery called the shunt surgery. There several points to be \nnoted when children with shunt live our normallifestyle. \nIn many cases of hydrocephalus emerging in childhood, it is treated by \nventriculo.peritoneal shunt (V.P shunt) surgery. A shunt comprises of a valve and a \ncatheter. By applying an external force , the valve and the catheter may be subjected to \npressure. It may case the catheter to become deformed and clogged or damaged. Thus \nphysical activities which may apply pressure on the valve or the catheter or cause \nsome objects to hit them should be avoided. \nSince the pressure of a programmable valve is adjusted using magnetic force , it may \nbe affected by magnets and so forth. \nShunt system can cause shunt troubles. If shunt occlusion or shunt infection occurs, \nthe patient will have symptoms such as headache, vomiting, dizziness, frustration, red \nswelling of the skin along the catheter and inability to keep balance of the body. If the \nabove symptoms appear, we must suspect a shunt trouble. \nIt may be necessary to caution other children to be careful with a child with shunt \nwhen they live together in kindergartens or nursery schools. \nWhen nursing children with shunts, the following precautions are required: \nCD Do not hit the valve or catheter in any way during physical activities. \n@ Avoid bringing magnets from coming into contact with the valve and strong \nmagnetic fields. \n@ Do not miss the signs of shunt troubles. \n@ Inform other children to be careful.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":79877558,"openaccessinfo":{"externalids":{"MAG":"2747124450","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Alkali gas lasers based on rubidium vapor have an extremely narrow absorption band (<0.01 nm at STP) at 780 nm. Diode-pumped alkali lasers (DPALs) require high-power diode arrays having emission spectra which are closely matched to this absorption peak. There are several methods which can be used for narrowing and stabilizing the output spectrum of a diode laser bar including external locking via a volumetric holographic grating (VHG). While this approach offers several advantages over internal stabilization techniques, the effect of pointing error arising from bar smile can be detrimental to the locked performance of the lensed array. In order to investigate the effect of smile on wavelength locking, a system capable of mapping the emission spectrum of the lensed diode laser bar was developed. The approach utilizes an imaging system and spatial filter to couple light from individual emitters of the lensed array into a commercial optical spectrum analyzer. This approach offers a larger dynamic range than traditional spectral mapping techniques, with a resolved signal to noise ratio in excess of 60 dB. Results from the characterization of a VHG-locked 780 nm laser bar array will be presented.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":52064435,"openaccessinfo":{"externalids":{"MAG":"2021563848","ACL":null,"DOI":"10.1117\/12.2040400","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Several authors have discussed an alteration of adrenergic receptivity in arterial hypertension. De Champlain (Hypertension 1990; 8: S77-S85) suggested that postsynaptic alpha 1-adrenergic functions became dominant while beta-adrenergic functions are attenuated in arterial hypertension. However, the status of presynaptic alpha 2-adrenoceptors remains unknown. The present study investigates presynaptic alpha 2-adrenoceptors in hypertension through the measurement of plasma levels of noradrenaline after administration of yohimbine, an alpha 2-adrenoceptor antagonist, in essential hypertension. Yohimbine (0.2 mg\/kg per os) induced a 73% increase of plasma levels of noradrenaline in hypertensive patients (n = 12) and a 178% one in normotensive subjects (n = 6, p < 0.05). A similar significant difference was found in experimental neurogenic hypertension observed in awake dogs 3 weeks after sinoaortic denervation: the increase in plasma concentrations of noradrenaline after yohimbine (0.5 mg\/kg i.v.) was +279% in hypertensive versus +642% in normotensive dogs (p < 0.05). The results show that the magnitude of the yohimbine-induced sympathetic activation is lower in hypertensives than in normotensives. They suggest the existence of a presynaptic alpha 2-adrenoceptor desensitization in arterial hypertension. The abnormality of this presynaptic inhibitory mechanism can increase the sympathetic tone and help to develop and maintain arterial hypertension.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23984367,"openaccessinfo":{"externalids":{"MAG":"2417412078","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Increased share of renewable sources of energy in a power grid leads to larger deviations in grid frequency from the nominal value resulting in more challenging control and its modelling. In this paper we focus on the grid frequency for the power system of Great Britain because the large share of renewables makes it a template for other power grids in the future and because it exhibits peculiar statistical properties, such as long-term correlations in fluctuations, periodicity, bi-modality, and heavy tails in the distribution of the grid frequency. By modifications of the swing equation and the underlying noise statistics, which we justify qualitatively and quantitatively, we reproduce these peculiar statistical properties. We apply our model to realistic frequency response services and show our predictions outperform a standard swing equation model.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":233296714,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/TPWRS.2022.3163336","PubMedCentral":null,"ArXiv":"2104.09289"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background ACPA-negative and ACPA-positive Rheumatoid Arthritis (RA) are increasingly regarded as separate clinical entities. Although ACPA-negative patients have a less severe disease course at group level, considerable inter-individual differences in the amount of joint destruction occur. Objectives As no studies focusing on genetic risk factors underlying the differences in joint destruction in ACPA-negative patients have been performed thus far, we performed the present study. Methods A Genome-Wide Association Study was performed using Illumina Human CytoSNP-12v2 in relation to radiographic joint destruction in 276 ACPA-negative early RA-patients included in the Leiden Early Arthritis Clinic (EAC). According to the Bonferroni correction on the number of tested SNPs, the threshold for genome wide significance was p<2x10-7. Subsequently, the significant SNPs were evaluated for association with the progression of radiographic joint destruction in 253 ACPA-negative early RA-patients included in the BARFOT-study. As 11 uncorrelated SNPs were tested, the Bonferroni threshold for significance was 0.0045. In all patients, joint destruction was measured by Sharp-van der Heijde Score with good reproducibility. Results 33 SNPs associated significantly to the severity of joint damage (p<2x10-7) in phase-1. In phase-2, two SNPs showed a trend towards a significant association with joint damage, rs2833522 (p=0.0049) and rs17763915 (p=0.047). A combined analysis of both the Leiden and BARFOT datasets of rs2833522 showed a highly significant association with joint destruction (p=3.57x10-9), the presence of the minor allele associated with more severe damage. Conclusions Rs2833522 might be associated with the severity of joint damage in ACPA-negative RA. Larger, longitudinal, studies are needed for confirmation. Acknowledgements This work is supported by the Masterswitch project and BtheCure project. The work of Annette van der Helm-van Mil is supported by the Dutch organization for scientific research (ZonMW). The Dutch Arthritis Foundation (Reumafonds) provided financial support for the genotyping. Disclosure of Interest None Declared","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":73010997,"openaccessinfo":{"externalids":{"MAG":"2094623209","ACL":null,"DOI":"10.1136\/annrheumdis-2013-eular.226","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"| The purpose of this study was to evaluate the nutritive value of total mixed ration (TMR) silage containing intact and defatted black soldier fly larvae (BSFL) as ruminant feeds. The BSFL was included as an ingredient in TMR according to the following treatments: ensiled TMR (R1), ensiled 80% TMR + 20% intact BSFL (R2), ensiled 80% TMR + 20% chemically defatted BSFL (R3), and ensiled 80% TMR + 20% mechanically defatted BSFL (R4). Each treatment was performed in five replicates. Ensiling was performed in lab scale silo and stored for 30 d. All dietary treatments were subjected to chemical composition determination and in vitro incubation with buffered-rumen fluid. Results showed that R2, R3, and R4 had higher crude protein (CP) contents than R1 both before and after ensiling. The ether extract (EE) contents in R3 and R4 were lower compared to R2. Ruminal ammonia concentration of R2 was the lowest compared to all treatments, while treatment R3 had the highest ammonia concentration (p<0.05). In vitro organic matter digestibility (IVOMD) parameter showed that R1, R3, and R4 treatments were higher than R2 (p<0.05). Total gas production in R1 and R2 was lower than treatments in R3 and R4, and the total gas production of R3 was the highest compared to all treatments (p<0.05). Methane production was not altered due to dietary treatments. In conclusion, defatted BSFL can be included in TMR silage without causing any adverse effect on the nutritional value of the silage.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226596229,"openaccessinfo":{"externalids":{"MAG":"3080894630","ACL":null,"DOI":"10.17582\/journal.jahp\/2020\/8.3.138.144","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.17582\/journal.jahp\/2020\/8.3.138.144","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Much debate persists as to whether or not the effects of the ongoing Arab Spring will actually serve to strengthen global security. Understandably, much of the debate has centered on the events unfolding in Egypt as the ousting of former President Hosni Mubarak has led to the ascendency of the unabashedly Islamist organization the Muslim Brotherhood. Although the Brotherhood has yet to take a provocative foreign policy stance in terms of supporting terrorism as a means to effect political change, this paper seeks to contribute to the debate surrounding the overall impact of the Arab Spring by examining instances in which the Brotherhood has either unquestionably engaged in violence or has directly supported terrorist organizations to the aim of predicting the likelihood as to whether or not the Brotherhood, now being in power in Egypt, will indeed embrace support of terrorism as a part of its foreign policy. The paper also examines Brotherhood activity in Egypt as well as the activities of Brotherhood subsidiary and front organizations operating throughout the greater Middle East and in Western nations in order to determine if the Brotherhood's stated goals of establishing Islamic Sharia law poses any substantial threat to the national security of otherwise secular states. Accordingly, the paper finds that the Muslim Brotherhood is willing to support terrorism violence in such instances as attempts to effect political change through peaceful means become increasingly frustrated and in such instances as the Brotherhood does not view violence as terrorism per se, but rather as a legitimate means to resist a perceived occupying force.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56034152,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The general circulation of the Southern Hemisphere stratosphere during 1987 is analyzed based on National Meteorological Center analyses, and contrasted to a climatological average constructed from the years 1980-1986. The polar lower stratosphere in spring 1987 is substantially colder than the climatology, with zonal mean differences of order 16K near 50 mb in November. Substantially warmer temperatures (near 8K) are observed in these data in the polar upper stratosphere coincident with the lower level cooling. Associated with the strong cooling in the lower stratosphere is a delay in the spring final warming during 1987 of approximately 20 days (compared with climatology). Although the majority of the observed cooling probably results from the record low ozone levels observed during 1987, the observed planetary wave driving during 1987 is substantially below climatological levels, also contributing to a colder pole.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140198201,"openaccessinfo":{"externalids":{"MAG":"2086758586","ACL":null,"DOI":"10.1029\/GL015I008P00911","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the context of hybrid anti-lock brake systems (ABS), we provide a closed-loop wheel-acceleration controller based on the observation of the extended braking stiffness (XBS). Its objective is to improve the system's robustness with respect to changes in the environment (as changes in road conditions, brake properties, etc.). In our design, we take advantage of Burckhardt's tyre model, in order to obtain a wheel acceleration dynamics that is linear up to time-scaling. The XBS is one of the state variables of this model. Our main result is an observer that estimates this unmeasured variable. The observer's convergence analysis is established using tools for switched linear systems that allow us to ensure its uniform exponential stability (provided that a dwell-time condition is satisfied). Our simulation results confirm the convergence properties predicted by our main theorem.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":27518526,"openaccessinfo":{"externalids":{"MAG":"2011188973","ACL":null,"DOI":"10.1109\/ACC.2013.6580151","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Periodontal diseases are associated with chronic inflammation. The destruction of connective tissue matrix is responsible for the pathogenesis of chronic inflammatory states. The degradation of matrix is initiated extra and pericellularly by proteinases produced locally at the inflammatory site. The regulation of these proteinases are by inhibitors present in serum and extravascular tissues, and it is the proteinase\/proteinase inhibitor balance that determines the progression of chronic inflammatory state. Few contradicting studies are available on changes in the levels of proteinase inhibitors in serum in periodontal disease. The occurrence of these inhibitors in saliva has not been studied in detail. The present study was aimed at measuring the Proteinase inhibitors in serum and saliva of patients with periodontal disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30079594,"openaccessinfo":{"externalids":{"MAG":"2411745246","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Biochemical vitamin E deficiency and low plasma lipids are frequent findings in patients with cystic fibrosis (CF). The response to a single oral dose of all-rac-alpha-tocopheryl acetate [100 IU (100 mg)\/kg body wt] was studied over 24 h in 25 CF patients with exocrine pancreatic insufficiency and in 23 healthy individuals. Patients received pancreatic enzymes together with the vitamin E test dose. At baseline, plasma alpha-tocopherol concentrations correlated with cholesterol concentrations; both were lower in patients than in control subjects, as were erythrocyte alpha-tocopherol concentrations (all P < 0.0001). Plasma and erythrocyte alpha-tocopherol concentrations were significantly higher than baseline concentrations from 3 and 6 h onward, respectively, and peaked most frequently at 6 and 12 h, respectively, in both patients and control subjects. Maximum increases and areas under the concentration time curves for plasma alpha-tocopherol concentrations were smaller in patients than in control subjects (P < 0.0001). When ratios of plasma alpha-tocopherol to cholesterol (to correct for differences in cholesterol concentrations) or erythrocyte alpha-tocopherol concentrations were applied, patients were shown to respond as efficiently as control subjects. On the basis of these results, we recommend vitamin E supplements in doses high enough to achieve vitamin E status in CF patients well within the range of healthy individuals; these supplements should be given with appropriate amounts of pancreatic enzymes. However, for long-term supplementation much lower doses than those used in this test situation may be sufficient.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4459629,"openaccessinfo":{"externalids":{"MAG":"2339321981","ACL":null,"DOI":"10.1093\/AJCN\/63.5.717","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Preformed Particle Gels are successfully used for profile control in heterogeneous reservoirs. However, it is still unclear how to select proper PPG size for a given heterogeneous reservoir. In order to obtain the best profile control performance, it is necessary to study the matching relationship between the PPG mesh and the permeability ratio.\n In this paper, the heterogeneous parallel-dual-sandpack experimental setup is established, including the injection system, measurement systems for temperature and pressure. During the experimental processes of water injection, PPG injection and subsequent water injection, the fractional flow of the two sandpacks with high and low permeability are recorded respectively. Then, a quantitative characterization parameter of the profile improvement ability is defined by dividing the change of fractional flow of the low permeable sandpack before and after PPG injection by that of low permeable sandpack before PPG injection.\n The experimental results show that different PPG meshes will achieve different profile control performance for the heterogeneous sandpack with the determined permeability ratio. The PPG with excessive large size may block the low permeable area, decrease its fractional flow and thus cause more severe flow heterogeneity. The PPG with excessive small size can not well block the high permeability area and they can migrate out during subsequent water injection resulting in the increase of fractional flow in high permeable area again. The matching relationship analysis show that the matched PPG mesh increases as the permeability ratio of the heterogeneous sandpack increases. In detail, the matched PPG sizes for the permeability ratio of 2, 4, and 6 are 120-150 mesh, 100-120 mesh and 60-80 mesh, respectively.\n The paper studied the matching relationship between PPG size and permeability heterogeneity, which was beneficial for selecting the proper PPG size for different heterogeneous reservoirs in more future applications.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":189364655,"openaccessinfo":{"externalids":{"MAG":"2903578659","ACL":null,"DOI":"10.2118\/193709-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fertilizer resources, especially phosphates and potassium are fast getting depleted. They also have poor use efficiency, burden farm economy, and pollute entire ecosystem. It was, therefore aimed to develop novel process and materials using nanotechnology. Novel process (patents applied) of nanofabrication and beneficiation of Rock Phosphate ore led to heavy-metal free phosphate-rich minerals and Zn-products. Novel P and Zn nanoproducts (patents applied) ensured supply of nutrients in plant available forms, and in conformity to environmental quality.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":112333603,"openaccessinfo":{"externalids":{"MAG":"2356497836","ACL":null,"DOI":"10.17756\/NWJ.2016-018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Metal ion capacitors (MICs) are foreseen to be a complementary alternative of vital importance to current energy storage issues, coupling high energy density delivered by batteries with high power\/long cycle life offered by supercapacitors. The prime issues in realising this technology are pre-metallation and replacement of graphite electrodes that bring about an energy gain at the expense of power. Herein we present an easy-to-scale-up approach, combining activated carbon with a highly efficient and industrially compatible low-cost sacrificial salt (dimetal squarates) that can be used as a metal source for pre-metallation. Paired with a hard carbon electrode tailored to perform at high rates, lithium, sodium and potassium MICs are demonstrated. Furthermore, the successful fabrication of a lithium ion capacitor (LIC) pouch cell prototype with high energy at high power densities showing capacitance retention over 84% after 48\u2006000 cycles validates the strategy. This breakthrough may trigger the easy and low-cost fabrication of LICs and significantly reduce technological barriers to market growth and consolidation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":218922317,"openaccessinfo":{"externalids":{"MAG":"3023788202","ACL":null,"DOI":"10.1039\/d0ee00351d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The heterogenous polymerization of methyl methacrylate in the presence of cuprous oxide was studied. Adsorption measurements of stearic acid from benzene solution onto the surface of Cu2O were carried out. The specific surface area of cuprous oxide as obtained from the extrapolation to the concentration of monolayer surface coverage in the adsorption isotherm was compared with that evaluated from the BET-equation. Sedimentation volume and sedimentation rate of the variably surface modified Cu2O samples were determined. It was found that the surface modification of Cu2O enhances its catalytic effect in the heterogenous polymerization of methyl methacrylate up to monolayer surface coverage. The viscosity average molecular weights Mv of the respective polymers as well as the apparent activation energy of the polymerization process were correlated with the reaction parameters.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":94963928,"openaccessinfo":{"externalids":{"MAG":"2030891342","ACL":null,"DOI":"10.1002\/APP.1990.070410908","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Computerized tomographic (CT) scanning and magnetic resonance imaging (MRI) can demonstrate areas of abnormal tissue within the brain, sometimes smaller than can be safely found and biopsied by open surgery or free-hand needle techniques. Image guided stereotaxic surgery can accurately and reproducibly place a needle in the brain based upon data from high resolution images. Tissue biopsy, abscess or cyst drainage, placement of radioactive seeds, or removal of a parenchymal hematoma can be done with less patient morbidity and in-hospital time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31675262,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In many studies of longevity in experimental animals, sample sizes are small enough to warrant the use of statistical tests of significance in making judgments of scientific interest. Illustrated in this paper is a nonparametric test procedure for deciding on the statistical significance of observed differences in two empirical survival functions. This procedure takes an experimenter one step beyond comparing means and medians. For experimenters who wish to pursue the subject further, a brief entry into the extensive literature on survival analysis is also provided.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40592974,"openaccessinfo":{"externalids":{"MAG":"2034140970","ACL":null,"DOI":"10.1093\/GERONJ\/39.1.36","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We examine how an Irish stigmatised neighbourhood is represented by Google Street View. In spite of Google's claims that Street View allows for 'a virtual reflection of the real world to enable armchair exploration' (McClendon, 2010). We show how it is directly implicated in the politics of representations. We focus on the manner in which Street View has contributed to the stigmatisation of a marginalised neighbourhood. Methodologically, we adopt a rhetorical\/structuralist analysis of the images of Moyross present on Street View. While Google has said the omissions were 'for operational reasons', we argue that a wider social and ideological context may have influenced Google's decision to exclude Moyross. We examine the opportunities available for contesting such representations, which have significance for the immediate and long-term future of the estate, given the necessity to attract businesses into Moyross as part of the ongoing economic aspect of the regeneration of this area.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":29118641,"openaccessinfo":{"externalids":{"MAG":"2161625732","ACL":null,"DOI":"10.1177\/1461444812465138","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Esophageal strictures commonly cause dysphagia and require treatment with endoscopic dilation using balloons or bougies. We aimed to determine whether biopsy forceps disruption of strictures at time of dilation increases time to repeat intervention or duration of intervention-free follow-up. We performed a retrospective analysis of 289 adults (age 61.0\u2009\u00b1\u20090.8\u00a0years, 66.4% female) who underwent dilation of an esophageal stricture at our tertiary care center between 2014 and 2016. Exclusions consisted of endoscopic intervention within the preceding 6\u00a0months, prior foregut neoplasia, achalasia, radiofrequency ablation, endoscopic mucosal resection, endoscopic submucosal dissection, or foregut surgery. Demographics, clinical presentation, dilation technique, and follow-up were abstracted from electronic medical records. We compared time to repeat dilation and duration of intervention-free follow-up between treatment subgroups. Balloon dilation was performed more often than bougie dilation (76.8 vs. 17.6%); biopsy forceps disruption was performed in 23.2%. Over a median follow-up of 52.9\u00a0months, 135 patients (46.7%) underwent repeat dilation. Age, body mass index, gender, and use of antisecretory medications did not influence need for repeat dilation (P\u2009=\u2009ns for each). Bougie dilation with biopsy forceps disruption prolonged time to repeat dilation in all patients (P\u2009\u2264\u20090.02), particularly in those with gastroesophageal reflux disease (P\u2009\u2264\u20090.03), compared with bougie dilation alone and balloon dilation with or without disruption. On Kaplan-Meier analysis, bougie dilation with biopsy forceps resulted in longer intervention-free follow-up compared with dilation alone (P\u2009=\u20090.03). We conclude that stricture disruption with biopsy forceps increases time to repeat intervention with bougie but not balloon dilation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":227167320,"openaccessinfo":{"externalids":{"MAG":"3108588605","ACL":null,"DOI":"10.1093\/dote\/doaa113","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper provides an overview of current issues in integration in couple and family therapy. It summarizes the evolution of integration in couple and family therapy, the various traditions in integration, the strengths of integrative approach, and\u00a0the possible pitfalls involved. It highlights the extent to which most couple and family therapy is now integrative practice. It concludes with a consideration of an emerging trend toward methods of practice centered on modules of intervention that have been identified as effective with certain presenting phenomena. The example of therapy for high conflict divorce is utilized to illustrate how various components can be brought together to create a maximally effective intervention.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":198172945,"openaccessinfo":{"externalids":{"MAG":"2964331947","ACL":null,"DOI":"10.1111\/famp.12473","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Online shopping is attractive to consumers because they can look for and compare products faster and easier. However, as the number of products available online rapidly increases, consumers are required to spend more time and efforts searching for relevant product information. As a result, curated shopping, which recommends a limited number of products carefully chosen by professional shopping curators, is becoming more popular among online consumers. In this study, we empirically investigate how the consumers' perceived risk, perceived value of curated shopping, and personal characteristics affect their decision to use curated shopping. Our results show that the perceived convenience, the efficiency of curated shopping, and the degree of shopping fatigue are positive factors that increase the intention to use curated shopping. On the other hand, the perceived financial risk is shown to be a significant negative factor. Furthermore, we found that previous experiences of curated shopping moderate the aforementioned relationships. The academic and practical implications of these findings are discussed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":53459796,"openaccessinfo":{"externalids":{"MAG":"2781595511","ACL":null,"DOI":"10.24251\/HICSS.2018.452","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The main properties of chars produced from corn stover, either by pyrolysis at 550\u00b0C (to produce biochar) or by hydrothermal carbonisation (to produce hydrochar), were studied. Carbonaceous materials were characterised by: SEM imaging, solid-state 13C NMR, FT-IR, Raman spectroscopy, and XPS. The following parameters were determined: elemental composition, cation exchange capacity, acid groups contents, BET, and yield. The hydrochar had a low ash content and low pH (4.7); recovery of C was high (57%), although only about half of the C was aromatic. Atomic O\/C and H\/C ratios in the hydrochar were higher than in the biochar. The same pattern was observed for the estimated concentration of carboxylic functional groups (0.07 compared with 0.04\u2009mol\/kg). The biochar had higher ash content than the hydrochar, and also higher pH (~10) (lime equivalence ~40\u2009kg CaCO3\/t). The C recovery (46%) was lower than in the hydrochar, although most of the C recovered was aromatic. Both chars could be used as soil amendments, for very different requirements. Soil responses and the residence times of the chars (especially the hydrochar) must be studied in detail to pursue long-term C sequestration.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":128488807,"openaccessinfo":{"externalids":{"MAG":"2066797583","ACL":null,"DOI":"10.1071\/SR10010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:From the Shang-Zhou period to the Han dynasty, the ritual of human-spirit resonance, a major exercise of the ancient Chinese wu-shamanistic tradition with a strong emotional component, had evolved into various modes of resonance and correlation. Together these correlative modes explain the social, political, ethical, medical, psychological, aesthetic, and cosmological processes. Classical Chinese thinkers used the term gan \u611for resonance to connote the motivating and connecting force for correlation, interaction, and interpenetration in a world of ever-changing relations. This motivating and connecting force is based on human emotional energy and enhanced with the ethical and rational strength of humanity and the functioning power of a correlative, symbiotic, and harmonious cosmos.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":147348560,"openaccessinfo":{"externalids":{"MAG":"2339526560","ACL":null,"DOI":"10.1353\/PEW.2016.0040","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Resonant microcantilevers have demonstrated that they can play an important role in the detection of chemical and biological agents. Molecular interactions with target species on the mechanical microtransducers surface generally induce a change of the beam's bending stiffness, resulting in a shift of the resonance frequency. In most biochemical sensor applications, cantilevers must operate in liquid, even though damping deteriorates the vibrational performances of the transducers. Here we focus on diamond-based microcantilevers since their transducing properties surpass those of other materials. In fact, among a wide range of remarkable features, diamond possesses exceptional mechanical properties enabling the fabrication of cantilever beams with higher resonant frequencies and Q-factors than when made from other conventional materials. Therefore, they appear as one of the top-ranked materials for designing cantilevers operating in liquid media. In this study, we evaluate the resonator sensitivity performances of our diamond microcantilevers using grafted carboxylated alkyl chains as a tool to investigate the subtle changes of surface stiffness as induced by electrostatic interactions. Here, caproic acid was immobilized on the hydrogen-terminated surface of resonant polycrystalline diamond cantilevers using a novel one-step grafting technique that could be also adapted to several other functionalizations. By varying the pH of the solution one could tune the -COO(-)\/-COOH ratio of carboxylic acid moieties immobilized on the surface, thus enabling fine variations of the surface stress. We were able to probe the cantilevers resonance frequency evolution and correlate it with the ratio of -COO(-)\/-COOH terminations on the functionalized diamond surface and consequently the evolution of the electrostatic potential over the cantilever surface. The approach successfully enabled one to probe variations in cantilevers bending stiffness from several tens to hundreds of millinewtons\/meter, thus opening the way for diamond microcantilevers to direct sensing applications in liquids. The evolution of the diamond surface chemistry was also investigated using X-ray photoelectron spectroscopy.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":28743354,"openaccessinfo":{"externalids":{"MAG":"2332646103","ACL":null,"DOI":"10.1021\/la2013649","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.archives-ouvertes.fr\/hal-00740839\/file\/article_AlexandreBongrain_LaHouilleBlanche.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Extensive use of organophosphorus pesticides (OPs) could alter semen quality and sperm DNA at different stages of spermatogenesis. Acephate is a highly toxic extensively used OP and, therefore, we aimed to evaluate the effects of acephate on human semen quality and sperm DNA integrity. Sperm collected from healthy males were exposed to 0, 50, 100, and 200\u2009\u03bcg\/mL of acephate and incubated for 1\u2009h, 2\u2009h, and 3\u2009h. Subsequently, sperm motility, vitality, functional integrity of plasma membrane, sperm capacitation, and DNA damage were examined. Result showed a significant decline of the motility at 100\u2009\u03bcg\/mL after 3\u2009h and with 200\u2009\u03bcg\/mL after 1\u2009h, 2\u2009h, and 3\u2009h. Viability was significantly reduced at 200\u2009\u03bcg\/mL after 2\u2009h and 3\u2009h. Functional integrity was significantly affected at 100\u2009\u03bcg\/mL after 3h and in 200\u2009\u03bcg\/mL dose after 2\u2009h and 3h. Similarly, sperm capacitation was significantly affected at 200\u2009\u03bcg\/mL after 1\u2009h, 2\u2009h, and 3\u2009h and at 100\u2009\u03bcg\/mL at 3\u2009h. DNA damage was significantly increased only in 200\u2009\u03bcg\/mL dose after 3\u2009h. The study suggests that exposure to acephate may result in alterations of sperm structure and function thus contributing towards deteriorating in human semen quality triggering infertility.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":18688917,"openaccessinfo":{"externalids":{"MAG":"2601044096","ACL":null,"DOI":"10.1155\/2017\/3874817","PubMedCentral":"5368408","ArXiv":null},"license":"CCBY","url":"http:\/\/downloads.hindawi.com\/journals\/jt\/2017\/3874817.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Summary The pathological changes occurring in a series of 1000 consecutive appendicectomies are reviewed. Normal appendix was diagnosed in 14% of cases, while 561 (56%) exhibited acute appendicitis; 53 (5%) had chronic inflammatory infiltrate associated with obliteration of the lumen of the tip of the appendix. Epithelial abnormalities included carcinoid tumours (1.4%), and primary appendiceal adenocarcinoma (1 case). There were a large variety of other abnormalities found and each one is briefly described.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2165234,"openaccessinfo":{"externalids":{"MAG":"2149626059","ACL":null,"DOI":"10.3109\/00313027709094453","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Adenosylhomocysteine hydrolase (EC 184.108.40.206) from calf liver was purified to homogeneity by crystallization. The purified enzyme exhibited one single component in polyacrylamide gel electrophoresis. But by Ampholine gel electrophoresis, two isoelectric focusing variants were observed, with pI values at 5.8 and 6.0. when subjected to polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate, one major subunit with a molecular weight of 60,000 was found; five other minor subunit variants were also observed, with molecular weights ranging between 50,000 and 57,000. These minor subunit variants comprised approximately 15% of the total protein applied. The molecular weight of the native enzyme was estimated to be 237,500 by gradient gel electrophoresis. The native enzyme is probably composed of four subunits, each with a molecular weight of not more than 60,000. Amino acid analyses of the purified enzyme revealed the presence of 1.2 residues of glucosamine\/mol of enzyme, in addition to all of the common amino acids. The presence of enzyme-bound NAD was confirmed, probably 1 NAD molecule bound\/enzyme subunit. In addition to adenosine, 3-deazaadenosine was found to be an effective substrate as well in the direction of synthesis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40937410,"openaccessinfo":{"externalids":{"MAG":"1852004395","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Four systematic spacing trials were planted between 1969 and 1973 on three islands in the Republic of Kiribati which have contrasting regimes of rainfall, in order to investigate the spacing requirements of coconuts in relation to rainfall (under atoll conditions). Two of the trials are on Kiritimati, which has an annual average rainfall of only 870 mm; one is on Tarawa which receives 2043 mm, and the fourth is on Butaritari which receives 3185 mm. Three of the trials are in the form of an almost complete wheel, whilst the fourth consists off our fan-shaped sectors. The range of planting densities in all trials was from 126 to, 632palms per hectare, in 12 treatments. Due to discontinuity of staff only one of the trials on Kiritimati was recorded during the period in which the coconuts came into, bearing but this showed fairly clearly that there is a relationship between precocity and planting density, with the palms coming into production earlier at the wider spacing. During the period of maximum cropping of the palms the optimum planting density under conditions of 870 mm annual rainfall is outside of the range of densities covered by the trials, and somewhat less than 126 palms per hectare. At 2000 mm rainfall, and for fertilized coconuts there is nearly equal yield per unit area of land within the range 169 to 304 palms per hectare, due to an inverse relationship between productivity per palm and number of palm per hectare. Number of fronds per palm and the rate of frond (and therefore bunch) production were inversely proportional to planting density, whilst trunk heights were directly proportional to planting density. The spacing to be chosen under these conditions will therefore be dependent upon other factors, such as the labour involved in digging the planting holes, whether the palms are to be intercropped, used for toddy or drinking nuts, whether the fronds are of significant value, and whether or not labour for subsequent maintenance is in short supply. In most situations, however, the lowest planting density which gives maximum productivity per unit area of land would be desirable. There were shifts in the optimum planting density in response to rainfall during the previous season, from which it might be inferred that on islands which receive significantly less than 2000 mm rainfall per annum, and especially if the coconuts are not fertilized, the optimum population density is somewhat less than 169 palms per hectare. A convenient round figure under these circumstances is a spacing of 9 meters triangular, which gives a planting density of 143 palms per hectare. Results from the trial on Butaritari were inconclusive due to only one year's full recording being obtained coupled with an unfortunate choice of site, but from the shifts which were observed in the trial on Tarawa in response to annual variations in rainfall it can be inferred that under high rainfall conditions a relatively high population density is optimal (but probably within the range 169 to 304 palms per hectare).","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":221901256,"openaccessinfo":{"externalids":{"MAG":"3028948726","ACL":null,"DOI":"10.37833\/cord.v12i01.300","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/doi.org\/10.37833\/cord.v12i01.300","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This study looks at the influence of an endoscope on the peristaltic flow of a particle--fluid suspension as blood model through tubes. A long wavelength approximation through a uniform and non-uniform infinite annulus filled with an incompressible viscous and Newtonian fluid mixed with rigid spherical particles of identical size is investigated theoretically. The inner tube is uniform, rigid and moving with a constant velocity V0, whereas the outer non-uniform tube has a sinusoidal wave travelling down its wall. The axial velocity of the fluid phase uf, particulate phase up and the pressure gradients have been obtained in terms of the dimensionless flow rate \\bar{Q}, the amplitude ratio \u03c6, particle concentration C, the velocity constant V0 and the radius ratio \u2208 the ratio between the radius of the inner tube and the radius of the outer one at the inlet. Numerical calculations for various values of the physical parameters of interest are carried out for the pressure rise and the friction force on the inner and the outer tubes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110566092,"openaccessinfo":{"externalids":{"MAG":"2150625007","ACL":null,"DOI":"10.1080\/11762320802376183","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1080\/11762320802376183","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly but also economically affordable in the developing world. To date, the performance of microbicide candidates in efficacy trials has been disappointing, but next-generation concepts now in or approaching clinical trials offer improved prospects for efficacy. The most plausible approaches involve topical application of antiretroviral agents with specific activity against HIV-1, compounds similar to drugs used to treat HIV-1 infection. How these inhibitors are applied may also be critical, with sustained-release formulations and vaginal ring delivery systems now becoming a high priority.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2628975,"openaccessinfo":{"externalids":{"MAG":"2160010002","ACL":null,"DOI":"10.1146\/ANNUREV.MED.59.061206.112737","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The influence of the flexibility moving path-overhead transmission line -on the inspection robot's dynamic response performance is studied through coupling dynamic simulation. First, a rigid multi-body dynamic model of the robot and a flexible multi-body dynamic model of a span of transmission line were built with Lagrange equation and modal synthesis method, respectively. Then the two models were coupled in the grasping point under two typical postures of passing obstacles. The dynamic response simulation of each posture was carried out with three different spans of flexible overhead transmission line. The laws governing impacts of flexible job environment upon the robot's dynamic response performance are explored through simulation results comparison and analysis.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":14469246,"openaccessinfo":{"externalids":{"MAG":"2114986634","ACL":null,"DOI":"10.1109\/COASE.2007.4341691","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a comparison of feature selection methods for a unified detection of breast cancers in mammograms. A set of features, including curvilinear features, texture features, Gabor features, and multi-resolution features, were extracted from a region of 512times512 pixels containing normal tissue or breast cancer. Adaptive floating search and genetic algorithm were used for the feature selection, and a linear discriminant analysis (LDA) was used for the classification of cancer regions from normal regions. The performance is evaluated using A z the area under ROC curve. On a dataset consisting 296 normal regions and 164 cancer regions (53 masses, 56 spiculated lesions, and 55 calcifications), adaptive floating search achieved Az=0.96 with comparison to Az=0.93 of CHC genetic algorithm and Az=0.90 of simple genetic algorithm","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":5600629,"openaccessinfo":{"externalids":{"MAG":"2153734103","ACL":null,"DOI":"10.1109\/IEMBS.2005.1615996","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The past few years have witnessed numerous media images of law enforcement officers shooting and in many cases, killing unarmed African American men and women. In significant amount of the cases, despite overwhelming video footage, police officers have not been held accountable for their actions. Most of the incidents have involved White policemen killing African American men. The study aimed at determining the covariates of shootings. Using the Racial Threat Hypothesis, victim characteristics and incident characteristics are investigated with the aim of identifying common themes that emerge surrounding shootings. Data were obtained from media coverage including newspaper, television footage and the Mapping Police Violence Database. Content analysis was performed on the data in order to identify common themes present in the shooting incidents. Two police officers were interviewed in order to ascertain whether their responses were consistent with the themes that have risen regarding police abuse of African American citizens. A major theme that developed in nearly all incidents was efforts by both local officials and police departments to dehumanize the victims. A second theme that emerged was to blame the victim, often by exaggerating his or her ability to harm an officer. It was concluded that to end police violence, reform is needed that takes into account justice, fairness, racism and racial stereotypes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":197754316,"openaccessinfo":{"externalids":{"MAG":"2921486589","ACL":null,"DOI":"10.3844\/jssp.2019.1.10","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.3844\/jssp.2019.1.10","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Nowadays, with the urbanization and globalization of trade, companies are facing fundamental challenges,This is why companies seek to stabilize and increase their market share while minimizing costs and maximizing profits. distribution problem as a structure constructed by the participants, represents the most important part of logistic expenses. Vehicle routing problem has been a growing interest as a distribution problem, it concerns to create the routes of a set of vehicles in order to deliver a list of customers, In the goal to minimize the cost of delivering goods. Open vehicle routing problem (OVRP) is an extension of vehicle routing problem where Each route could be a Hamiltonian path over the route's subset of customers. In this paper we provide an extension of the open vehicle routing problem, called Open vehicle routing problem with fuzzy time windows, we adopt a mathematical model for this type of problem, and by using alpha cut method through a decomposition of this original problem in their original fuzzy form into a set of crisp models (OVRPFTW) we propose a solution of this problem. Computational results indicate that this model can fulfill a significant cost-saving while securing a high level of service .","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":259219486,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.46254\/an13.20230209","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ieomsociety.org\/proceedings\/2023manila\/209.pdf","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Apoptosis is cellular suicide functionally opposite of mitosis. It plays an important role in tissue growth control and removal of damaged and premalignant cells. The decrease in death suppressor Bcl-2 protein level was implicated in the many types of apoptotic cell death. Because Bcl-2 protein was recently found to be cleaved during apoptosis induced by Fas ligation, IL-3 withdrawal, and alphavirus infection, we assessed whether Bcl-2 protein was also cleaved during the anticancer drug (VP-16)-induced apoptotic cell death in U937 cells. We found that Bcl-2 protein was cleaved in vivo and in vitro after the treatment of VP-16. We also found that caspase-3\/CPP32, which was activated after VP-16 treatment, was responsible for the direct cleavage of Bcl-2 protein. The overexpression of the cleaved Bcl-2 fragment increased the sensitivity to VP-16 and promoted apoptotic cell death. Therefore, caspase-3\/CPP32 accelerates VP-16-induced U937 cell apoptosis by cleaving death suppressor Bcl-2 protein to produce a death promoter Bcl-2 fragment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38030037,"openaccessinfo":{"externalids":{"MAG":"2055778010","ACL":null,"DOI":"10.1006\/BBRC.1998.8587","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have designed an experiment for the Omega \u2013 EP laser facility to measure the Rayleigh-Taylor (RT) growth rate of solid-state Ta samples at ~1 Mbar pressures and very high strain rates, 107\u2013108 s\u22121. A thin walled, hohlraum based, ramp-wave, quasi-isentropic drive has been developed for this experiment. Thick samples (~50 um) of Ta, with a pre-imposed sinusoidal rippled on the driven side, will be accelerated. The ripple growth due to the RT instability is greatly reduced due to the dynamic material strength. We will show detailed designs, and a thorough error analysis used to optimize the experiment and minimize uncertainty.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":99440324,"openaccessinfo":{"externalids":{"MAG":"2597544326","ACL":null,"DOI":"10.1088\/1742-6596\/244\/4\/042016","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/244\/4\/042016\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aim . To study age structure and population dynamics of locusts inhabiting Karachay-Cherkessia in different periods of ontogeny. Information on the periods of locusts hatching, growing to dominant species and their fertility can be used by plant protection services for the objective assessment of harmful species populations and predict their numbers in the region. Methods. The studies were conducted in the southern, central and northern regions of the republic. Studied material includes more than 6000 locust larvae and imago. Annually we conducted route study of locusts and multiple transect surveys which covered 36 most characteristic habitats. In the field and laboratories, we carried out experiments and studies on egg capsules and larvae. Results . The study revealed features of ontogeny and population dynamics of all the phases of development (egg, larva, imago) of five species of locusts (Omocestus haemorrhoidalis Ch., Chorthippus albomarginatus Deg., Chorthippus bigutullus L., Chorthippus apricarius L., Chorthippus mollis Ch.) in a variety of habitats. Conclusions. The average number of eggs in the egg capsules in the south region is more than in the north; the hatching of larvae is between 11 am and 4 pm, the average developmental period varies by age and region. From the hatched larvae (not more than 80% of the number of eggs laid) usually considerably more than half dies. For the existence of a stable population of the species under study, the annual number of eggs should be 10-20 times the number of adults. It was found that the number of locusts in Karachay-Cherkessia in general increases in dry warm years, and in mowed areas is higher.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":86052624,"openaccessinfo":{"externalids":{"MAG":"2226950972","ACL":null,"DOI":"10.18470\/1992-1098-2015-2-116-127","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.18470\/1992-1098-2015-2-116-127","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Continuous infusion unfractionated heparin (UH) has traditionally been monitored using the activated partial thromboplastin time (aPTT). The use of this test to monitor heparin therapy is not based on randomized controlled clinical trials, and the test is associated with significant intra- and inter-patient variability that is not related to circulating blood heparin activity. Due to these and other limitations, the use of aPTT alone to monitor UF has been questioned. Many laboratories are now transitioning to monitoring actual heparin activity (by anti-factor Xa analysis). In this review, we discuss the limitations of using the aPTT to monitor UH therapy and additionally the limitations of solely using heparin activity to monitor therapy. We also include a discussion of the challenges with monitoring heparin therapy in the pediatric population.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5109731,"openaccessinfo":{"externalids":{"MAG":"2164196526","ACL":null,"DOI":"10.1177\/0897190010362172","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Chien-Fu Jeff Wu was born January 15, 1949, in Taiwan. He \nearned a B.Sc. in Mathematics from National Taiwan University in 1971, and \na Ph.D. in Statistics from the University of California, Berkeley in 1976. He \nhas been a faculty member at the University of Wisconsin, Madison (1977\u2013 \n1988), the University of Waterloo (1988\u20131993), the University of Michigan \n(1995\u20132003; department chair 1995\u20138) and currently is the Coca-Cola Chair \nin Engineering Statistics and Professor in the H. Milton Stewart School of Industrial \nand Systems Engineering at the Georgia Institute of Technology. He \nis known for his work on the convergence of the EM algorithm, resampling \nmethods, nonlinear least squares, sensitivity testing and industrial statistics, \nincluding design of experiments, robust parameter design and computer experiments, \nand has been credited for coining the term \"data science\" as early \nas 1997. \nJeff has received several awards, including the COPSS Presidents' Award \n(1987), the Shewhart Medal (2008), the R. A. Fisher Lectureship (2011) and \nthe Deming Lecturer Award (2012). He is an elected member of Academia \nSinica (2000) and the National Academy of Engineering (2004), and has received \nmany other awards and honors including an honorary doctorate from \nthe University of Waterloo. \nJeff has supervised 45 Ph.D. students to date, many of whom are active \nresearchers in the statistical sciences. He has published more than 170 peerreviewed \narticles and two books. He was the second Editor of Statistica \nSinica (1993\u201396). Jeff married Susan Chang in 1979, and they have two children, \nEmily and Justin. \nThis conversation took place in Atlanta, Georgia, on April 21, 2015.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":64073033,"openaccessinfo":{"externalids":{"MAG":"2575573696","ACL":null,"DOI":"10.1214\/16-STS574","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Breast cancer is a malignancy with the highest incidence and mortality in women worldwide. Senescence is a model of arrest in the cell cycle, which plays an important role in tumor progression, while the prognostic value of cellular senescence-related genes (SRGs) in evaluating immune infiltration and clinical outcomes of breast cancer needs further investigation. In the present study, we identified two distinct molecular subtypes according to the expression profiles of 278 SRGs. We further explored the dysregulated pathways between the two subtypes and constructed a microenvironmental landscape of breast cancer. Subsequently, we established a senescence-related scoring signature based on the expression of four SRGs in the training set (GSE21653) and validated its accuracy in two validation sets (GSE20685 and GSE25055). In the training set, patients in the high-risk group had a worse prognosis than patients in the low-risk group. Multivariate Cox regression analysis showed that risk score was an independent prognostic indicator. Receiver operating characteristic curve (ROC) analysis proved the predictive accuracy of the signature. The prognostic value of this signature was further confirmed in the validation sets. We also observed that a lower risk score was associated with a higher pathological response rate in patients with neoadjuvant chemotherapy. We next performed functional experiments to validate the results above. Our study demonstrated that these cellular senescence patterns effectively grouped patients at low or high risk of disease recurrence and revealed their potential roles in the tumor\u2013immune\u2013stromal microenvironment. These findings enhanced our understanding of the tumor immune microenvironment and provided new insights for improving the prognosis of breast cancer patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251712398,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fimmu.2022.921182","PubMedCentral":"9441960","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.921182\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"SUMMARY Map units directly related to properties of soil-landscape are generated by local soil classes. Therefore to take into consideration the knowledge of farmers is essential to automate the procedure. The aim of this study was to map local soil classes by computer-assisted cartography (CAC), using several combinations of topographic properties produced by GIS (digital elevation model, aspect, slope, and profile curvature). A decision tree was used to find the number of topographic properties required for digital cartography of the local soil classes. The maps produced were evaluated based on the attributes of map quality defined as precision and accuracy of the CAC-based maps. The evaluation was carried out in Central Mexico using three maps of local soil classes with contrasting landscape and climatic conditions (desert, temperate, and tropical). In the three areas the precision (56 %) of the CAC maps based on elevation as topographical feature was higher than when based on slope, aspect and profile curvature. The accuracy of the maps (boundary locations) was however low (33 %), in other words, further research is required to improve this indicator.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":134265195,"openaccessinfo":{"externalids":{"MAG":"2738189512","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nInterprofessional education is essential to ensure that health care graduates are prepared for collaborative practice. One way to prepare students for interprofessional practice is to expose them to interprofessional activities throughout their educational program.\n\n\nMETHOD\nIn this article, we present the design and curricular implementation of an interprofessional health care escape room-a type of serious game in which teams of interprofessional participants were provided with a fictitious case. The participants were given 1 hour to work together to solve puzzles and create a postdischarge care plan for the patient.\n\n\nRESULTS\nSeven hundred eighty-six students, across four professions, have participated in this experience as part of an academic course. The results were positive: 89.5% of participants found that the activity improved communication and teamwork, and 94.1% felt that team members were listened to.\n\n\nCONCLUSION\nThis report demonstrates the value of an interactive interprofessional activity for advanced learners. [J Nurs Educ. 2020;59(1):46-50.].","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210703102,"openaccessinfo":{"externalids":{"MAG":"2999621462","ACL":null,"DOI":"10.3928\/01484834-20191223-11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Football is one of the most common extracurricular activities among schoolchildren. Illusions and expectations are poured into a competitive sport that complements their formal education at school. The controversy over competition in schoolchildren aged six and seven opens up a debate on the lessons that are constructed. This study explores the emotional management that children develop in order to participate in sports activities in relation to the lessons promoted by the school. This article presents an ethnographic study grounded upon participant observation, with 101 schoolchildren in the first and second years of primary school during one academic year in 207 sessions, and semi-structured interviews with 21 teachers. After analysing the narratives, the results reveal previous expectations and stresses, a level of activation adequate for the competitive demands of the environment, the development of the ability to be competent in a stressful situation, the emotional capitalization of knowing how to win and lose, the impact of social recognition on adaptative construction of self-esteem, and the management of episodes of stress.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149897334,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/02103702.2018.1504862","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effect of heavy ion (carbon beam) on apoptosis in vivo was studied. The human brain tumors xenografts of different radiosensitivities were used. The results demonstrated that the effect of carbon beam on apoptosis was similar to photon in radiosensitive tumors; however, carbon beam had the advantage on apoptosis in radioresistant tumors. In ependymoblastoma, a radiosensitive tumor, the incidence of apoptosis induced by photon and by carbon at 6 hours after irradiation were 34.5 +\/- 7.85% and 32.5 +\/- 7.04%, respectively. In glioblastoma (radioresistant tumor), the incidence of apoptosis induced by photon and by carbon at 6 hours after irradiation were 1.35 +\/- 1.68% and 4.4 +\/- 2.47%, respectively. Therefore, the incidence of apoptosis was increased more than 3-fold (RBE 3.0) at 6 hours after irradiation in glioblastoma. The heavy ion (carbon) beam is effective in radioresistant tumors in vivo.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21454871,"openaccessinfo":{"externalids":{"MAG":"280521954","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Complex studies were carried out on humoral and cell mediated immunity among persons over 60 years of age and persons aged 18-40. Humoral immune responses were not profoundly disturbed in the group of older persons. The level of isoagglutinins was lower in older subjects, but the level of immunoglobulins and antibodies to widespread bacterial and virus antigens (S. typhi O, Kunin's CA, Parainfluenza types I, II and III) was the same in both groups. Cell mediated immunity was more greatly changed. Response to PPD in skin tests, lymphocyte stimulation tests, and the migration inhibition test was reduced in older subjects. Also, in this group, PHA in lymphocyte stimulation tests and the number of E- rosette forming cells was lower than among younger adults. However, responses to other antigens in skin tests, lymphocyte stimulation tests, migration inhibition tests (Candida albicans, SK-SD, Trichophyton) and responses to other stimulants of the lymphocyte stimulation tests (Con A, PWM) were well preserved in older subjects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41742239,"openaccessinfo":{"externalids":{"MAG":"2322037035","ACL":null,"DOI":"10.1093\/GERONJ\/34.1.9","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": The use of fossil fuels has caused serious environmental problems such as air pollution and the greenhouse effect. Moreover, because fossil fuels are a non-renewable energy source, they cannot meet the continuously increasing demand for energy. Therefore, the development of clean and renewable energy sources is necessitated. Hydrogen energy is a clean, non-polluting renewable energy source that can ease the energy pressure of the whole society. The sunlight received by the Earth is 1.7 \u00d7 10 14 J in 1 s, which far exceeds the total energy consumption of humans in one year. Therefore, conversion of solar energy to valuable hydrogen energy is of significance for reducing the dependence on fossil fuels. Since Fujishima and Honda first reported on TiO 2 in 1972, it has been discovered that semiconductors can generate clean, pollution-free hydrogen through water splitting driven by electricity or light. Hydrogen generated through this approach can not only replace fossil fuels but also provide environmentally friendly renewable hydrogen energy, which has attracted considerable attention. Photoelectrochemical (PEC) water splitting can use solar energy to produce clean, sustainable hydrogen energy. Because the oxygen evolution reaction (OER) over a photoanode is sluggish, the overall energy conversion efficiency is considerably low, limiting the practical application of PEC water splitting. A cocatalyst is, thus, necessary to improve PEC water splitting performance. So far, the synthesis of first-row transition-metal-based (e.g., Fe, Co, Ni, and Mn) cocatalysts has been intensively studied. Iron is earth-abundant and less toxic than other transition metals, making it a good cocatalyst. In addition, iron-based compounds exhibit the properties of a semiconductor\/metal and have unique electronic structures, which can improve electrical conductivity and water adsorption. Various iron-based catalysts with high activity have been designed to improve the efficiency of PEC water oxidation. This article briefly summarizes the research progress related to the structure, synthesis, and application of iron oxyhydroxides, iron-based layered double hydroxides, and iron-based perovskites and discusses the evaluation of the performance of these cocatalysts toward photoelectrochemical water oxidation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":229252242,"openaccessinfo":{"externalids":{"MAG":"3097034330","ACL":null,"DOI":"10.3866\/pku.whxb202009022","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.whxb.pku.edu.cn\/CN\/article\/downloadArticleFile.do?attachType=PDF&id=36103","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This study was conducted to examine the effects of creatine (Cr) supplementation on sprint swimming performance and energy metabolism. Twenty highly trained swimmers (9 female, 11 male) were tested for blood ammonia and for blood lactate after the 25-, 50-, and 100-m performance in their best stroke on two occasions 7 d apart. After the first trial, subjects were evenly and randomly assigned to either a creatine (5 g creatine monohydrate 4 times per day for 5 d) or a placebo group (same dosage of a lactose placebo) in a double-blind research design. No significant differences in performance times were observed between trials. Post-exercise blood ammonia concentration decreased in the 50- and 100-m trials in the creatine group and in the 50-m trial in the placebo group. The supplementation period had no effect on post-exercise blood lactate. Therefore, creatine supplementation cannot be considered as an ergogenic aid for sprint performance in highly trained swimmers although adenine nucleotide degradation may be reduced during sprint exercise after 5 d of creatine ingestion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27693981,"openaccessinfo":{"externalids":{"MAG":"2091131729","ACL":null,"DOI":"10.1097\/00005768-199611000-00014","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.lww.com\/acsm-msse\/fulltext\/1996\/11000\/creatine_supplementation_does_not_improve_sprint.14.aspx","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"An experiment was conducted wherein masked thresholds (using ascending method of limits) for a backup alarm were obtained in pink and red noise at 85 and 100 dBA for 12 participants immersed in a probability monitoring task and wearing a conventional passive hearing protection device (HPD, an earmuff or a foam earplug), an active noise reduction (ANR) headset, or no HPD at all (only in 85 dBA noise). Results revealed statistically significant between-HPD differences in red noise (from 2.3 to 3.1 dB) and in the 100-dBA noise level (from 2.6 to 4.3 dB). An additional finding, which corroborates other studies using different protocols, was that masked thresholds in 85-dBA noise were significantly lower (from 3.2 to 4.4 dB) for the occluded conditions (wearing an HPD) than for the open-ear (unoccluded) condition. This result refutes the belief among many normal-hearing workers that the use of HPDs in relatively low levels of noise compromises their ability to hear necessary workplace sounds. Actual or potential applications of this research include (a) the selection of appropriate HPDs for low-frequency-biased noise exposures wherein signal detection is important and (b) gaining insight into the appropriateness of ANR-based HPDs for certain industrial noise environments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28163518,"openaccessinfo":{"externalids":{"MAG":"1968776662","ACL":null,"DOI":"10.1518\/hfes.46.1.1.30387","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A molecular approach to understand the photocatalytic degradation of small organic molecules adsorbed from the gas phase on anatase, rutile and doped TiO2 nanoparticles is presented. Using in situ Fourier transform infrared (FTIR) spectroscopy and mass spectrometry the rate determining steps for the photocatalytic degradation of formic acid, acetone and propane are unraveled. Key intermediates are identified and correlated to structural properties of the TiO2 nanoparticles. Specifically, stable bridging bidentate carboxylate (R-CO2) and (bi)carbonate species forms preferentially on rutile particles, and are proposed to inhibit the total photodegradation efficiency. In particular, the concentration of R-CO2 is found to decrease with increasing size of the anatase particles, and may at least partly explain why Degussa P25 is a good photocatalyst. Means to avoid R-CO2 site-blocking is discussed. Improved solar light efficiencies are difficulty to achieve in cation doped TiO2 despite higher visible light absorption and stronger adsorbate-surface interactions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":96039655,"openaccessinfo":{"externalids":{"MAG":"2032827203","ACL":null,"DOI":"10.1117\/12.680304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The Free Church and the Early Church: Bridging the Historical and Theological Divide. Edited by D. H. Williams. Grand Rapids, Mich.: William B. Eerdmans. 2002. Pp. 183. $16, paper. The early church has been problematic for the free churches. Free church scholars and layfolk alike have been concerned to be biblical and to accord primary authority to the life and witness of the apostolic church. Although they have at times made courteous comments about the early church, they in practice have vaulted across the centuries to the Protestant Reformation of the sixteenth century, at which point \"church history,\" as they conceive it, begins. Hence the free churches (with one exception, as will emerge later) have largely left scholarship in the early church to scholars in the Catholic traditions. This useful book signifies a change. Its writers--Baptists, Campbellites and a Mennonite--indicate various ways in which insights from the early church are being appropriated by contemporary free church thinkers. Editor Daniel Williams, a Baptist, argues that free church Christians today need the resources of the ancient church in order to \"construct a uniquely Christian vision in our present day.\" Williams uses the language of \"rediscovery\" and \"recovery\" in a way that will be familiar to Mennonites. Among Mennonites the \"recovery of the Anabaptist vision\" has been a potent impetus for renewal of thought and praxis. Does the early church hold out a parallel source of renewal for free churches, including Mennonites? Many articles in this book indicate the benefits that can come to the free churches by learning from the early church. One is coherence, especially regarding sola scriptura. The eminent patristics scholar Frederick Norris, who argues that the scriptural canon is the product of the late fourth-century church, asks provocatively: \"Does it make much sense to say that the fourth-century was making very good decisions about the Bible but mostly poor ones about everything else?\" Since the canon is situated within the church, Norris would have us draw wisdom from other aspects of the church's life--episcopacy, councils, creeds and ethical canons. A Mennonite theologian, Gerald Schlabach, in a penetrating study of Augustine, argues that Augustinian themes of grace and caritas can do much to correct the gracelessness and \"blunt voluntarism\" of free church ecclesiology. Schlabach also opens up another theme that deserves more development in this book--the benefits to the church catholic when scholars schooled in the free churches study the early church. Schlabach's sensibilities, shaped by Mennonite upbringing and theology, enable him to argue that Augustine's use of force to coerce erring Christians into the Catholic church represents an aberration from Augustine's own theology of continence--\"an act of incontinence, not trust, of a pride that was surely subtle but hardly the christlike humility that had converted him.\" Schlabach, who has drunk deeply from Augustinian wells, is nevertheless able, precisely because of his Mennonite roots, to see things in Augustine that are new and profound and have ecumenical resonance. When he invites other free church thinkers to engage in \"the debate that is Augustinianism,\" I wonder what response he will get. Another contributor, Church of Christ scholar Everett Ferguson, has for many years been at the center of the worldwide guild of patristics scholars. \u2026","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":159094501,"openaccessinfo":{"externalids":{"MAG":"312847447","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nucleoporins are a specialized subset of nuclear proteins that comprise the nuclear pore complex and regulate nucleocytoplasmic transport. Recent demonstrations of roles for individual nucleoporins in multiple paradigms of differentiation via mechanisms independent of nuclear trafficking represent conceptual advances in understanding the contributions of nucleoporins to cellular development. Among these, a functional role for nucleoporins in reproductive fitness and gametogenesis has been identified, supported by robust models and clinical studies that leverage the power of next generation sequencing technology to identify reproductive-disease-associated mutations in specific nucleoporins. Proper nucleoporin function manifests in different ways during oogenesis and spermatogenesis. However, nonhuman models of gametogenesis may not recapitulate human mechanisms, which may confound translational interpretation and relevance. To circumvent these limitations, identification of reproductive pathologies in patients, combined with next generation sequencing approaches and advanced in silico tools, offers a powerful approach to investigate the potential function of nucleoporins in human reproduction. Ultimately, elucidating the role of nucleoporins in reproductive biology will provide opportunities for predictive, diagnostic, and therapeutic strategies to address reproductive disorders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53270545,"openaccessinfo":{"externalids":{"MAG":"2898971418","ACL":null,"DOI":"10.1139\/cjpp-2018-0436","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc6613778?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This essay discusses progress and directionality, both in nature, in science and in society, treating as its starting-point the reflections, parallelisms and comparisons of Ruse's essay, 'A Threefold Parallelism for Our Time? Progressive Development in Society, Science and the Organic World', but reaching substantially different conclusions. The essay thus ranges over progress and directionality in the world of natural evolution, in the sciences and the humanities, and in history and society. It defends non-relative progress in science and the humanities, criticising here both the approach to these disciplines of the strongly evolutionary epistemology of Hull and the more moderate evolutionary epistemology of Ruse. It further defends the possibility of progress and directionality in history and society, and also, following Rolston, in the course of evolution within the world of nature, where the kind of directionality to be found has multiple directions rather than being unilinear. Subsequently it relates conclusions about these fields to theological reflections (characteristic of Judaism, Christianity and Islam) about the creation of nature and society by a value-loving intelligence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":147102188,"openaccessinfo":{"externalids":{"MAG":"2289518125","ACL":null,"DOI":"10.1163\/18722636-12341314","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/orca.cardiff.ac.uk\/87324\/2\/DIRECTIONALITYexpandedpaper.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The transformation of migration after October 1917 due to the inevitable radical reconstruction of the political and socio-economic system of society resulted in a change of its basic features. The theoretical basis of this transformation was laid during the years of military communism and was in much in demand at the end of the 1920s.Due to objective and subjective reasons, the transformation could not affect the migration of peasants to areas rich in agricultural land, which was closely linked to the stage of pre-war resettlement and colonization, and remained one of the central problems in the 1920s. The features of the regulation of these processes (the late start of planned resettlement in 1924-1925s and the end of resettlement of individual farms in 1930s, the abolition of the term \"colonization\") influenced the attitude towards processes that played an important role in the history of Russia. But the short period of resettlement and colonization in the 1920s was preceded by a period full of movements of peasants to the Asian part of Russia and of discussion of the prospects of this process. Therefore, it was impossible to ignore the pre-war trends and implications of relocation in the 1920s, as well as the great experience - informational, legislative and organizational \u2013 of resettlement. The \"conductors\" of such experience were scientists and experts. Some of them worked at the former Resettlement Department. However, an attempt to revive the resettlement plans contradicted the plans of the state. In the late 1920s, the state of resettlement was assessed as critical. At the same time, studies of colonization and migration were stopped.In fact, resettlement of peasants from the 1880s until the end of the 1920s was a single process. This circumstance determined the structure of the article. At the same time the least studied is the last stage - resettlement in the 1920s.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":185013323,"openaccessinfo":{"externalids":{"MAG":"2598486934","ACL":null,"DOI":"10.17323\/DEMREVIEW.V2I3.1776","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An evolutionary learning algorithm based on difierential evolution strategy (DES) and continuous ant colony optimization (CACO) for wideband antenna design is proposed. The advantages of this hybrid method are demonstrated with several mathematical functions and a linear array pattern synthesis. This method is applied to design an E-shaped wideband patch antenna, which achieves the impedance bandwidth 4:8 \u00bb 6:53GHz. We compare the hybrid method with the traditional DES and CACO optimization algorithms, and the advantage of this hybrid method over the DES and the CACO is also demonstrated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121938036,"openaccessinfo":{"externalids":{"MAG":"2162032459","ACL":null,"DOI":"10.2528\/PIER11092207","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"relatively unconcerned about surgical morbidity and mortality. By guessing, rather than asking, which risks a particular patient would find significant, do we not run the risk of inadequately informing patients, and therefore of potential legal consequences? Or would evidence that we tried, in good faith, to define the risks relevant to a particular patient \u2013 even if we get it completely wrong \u2013 be enough to formulate a legal defence of our practice? I fear that the Montgomery judgment has put us on the slow but inexorable road to consent booklets for anaesthesia and surgery, with page upon page of lists of potential risks to be read before an operation, so that a patient can be considered fully informed and able to consider which risks are material before discussing them with a clinician. These do already exist in other areas of medicine \u2013 for example, I recently received one before an endoscopy. On the plus side, we can look forward to increased time in our job plans for pre-operative assessment, given the inevitable rise in questions from, and explanation to, patients. Finally, I am often asked to comment on patients' fitness for anaesthesia. Aside from the fact that fitness is actually for surgery, rather than for any intervention I might provide, my answer is usually that if the patient requires an operation, is willing to accept the risks, and cannot be physiologically optimised any further, we should proceed. Extending deference to patient autonomy might at least have the welcome side effect that, as a profession, we will no longer refuse indicated surgery because the clinicians involved are uncomfortable with risks that our patients might willingly take.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251796976,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Surrogacy arrangements have been a feature of family formation for centuries. However, their practice has not been embraced as an acceptable way of allowing infertile couples to form a family. The notion of a surrogacy arrangement raises concern about what could go wrong. Commercial surrogacy is not permitted in Australia. However, each of the states in Australia has a different policy response to altruistic surrogacy. This article reviews the potential roles which governments may play in the regulation of altruistic surrogacy. Proponents of altruistic surrogacy arrangements argue that regulation would minimise harm to the people who are involved in such arrangements, and offer some protections. Opponents argue that such regulation raises concerns about the role of government intervening in private arrangements, interrupting the relationship between a doctor and patient, and providing paternalistic protection of its citizens. Government intervention to facilitate surrogacy may also be seen to legitimise a practice which has a low level of community acceptance and understanding. This article reviews those concerns. SURROGACY--ALL THE FEATURES OF A RELATIONSHIP THAT COULD GO WRONG? Surrogacy is not a new practice. Many quote the biblical references to surrogacy. (Genesis) The private diaries of Winston Churchill's wife Clementine revealed that she offered to give the couple's fourth child to Lady Jean Hamilton, a close family friend, unable to conceive. (Telegraph, 2001) Despite the longevity of the practice, the responses to surrogacy are varied and complex. The public policy responses to surrogacy partly arise from the challenge to the traditional notions of family and procreation. There are also difficulties in differentiating the boundaries between regulation of private behaviour and public good. This article explores some of those issues, with a view to arguing that surrogacy should be regulated to reduce risk and to ensure that patients are informed and protected in their decision-making. WHAT IS SURROGACY? A woman agrees to bear a child which will be handed to another woman, and her husband or partner, to become theirs. This is surrogacy. There are two different forms of surrogacy. Traditional surrogacy involves the insemination of the surrogate with the commissioning husband's sperm (1). This may occur through sexual intercourse or through artificial insemination. The surrogate mother therefore has a genetic link to the child. IVF surrogacy occurs where an embryo is formed in vitro from the sperm and the egg of the commissioning couple, the would-be parents, and then transferred to the womb of the surrogate mother. In this case the resulting child is the full genetic child of the commissioning parents, and only has a link to the surrogate through the gestational process. Other variations to IVF surrogacy may occur where, for example, donor egg or donor sperm is used, or both, where one or both of the commissioning couple are infertile. In such cases it is possible to distinguish between the genetic parent (the donor), the gestational parent (the surrogate) and the social parents (the commissioning couple). Surrogacy may be used for social reasons. For example, a woman may wish to avoid the physical effects of carrying a child. Medically indicated surrogacy may occur where the commissioning infertile woman does not have a uterus. She may still have functioning ovaries. In some cases the women may have a past history of both hysterectomy and bilateral salpingo-oophorectory which means she has neither uterus nor ovaries. In such cases donor eggs would be required. The requirement for surrogacy treatment is difficult to quantify in Australia. There is no central data collection on the number of children born as a result of surrogacy arrangements. Leeton, a strong advocate for IVF surrogacy, estimates that the number of cases in Australia where the woman has functioning ovaries but no functioning uterus and utilises a surrogate does not exceed 12 cases per year. \u2026","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2015-11":1,"2015-18":1,"unknown":2}},"corpusid":140888282,"openaccessinfo":{"externalids":{"MAG":"167151914","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The admission of non-human animals as sensible beings and possessors of interests is a historical and cultural process in constant development, no more restricted to the philosophical field, reaching also the legal scope and fomenting the discussion about the use (or not) of animals in experiences. Therefore, the objective of this work is to show how the debate about the non-human animal has been received in Brazil and how its legislation has following this theme. Through a theoretical and legal-normative analysis, the present study concludes that exist an increasing concern in protecting the animals against cruelty, towards their recognition as beings with dignity and also subjects of rights. However, it is necessary that society (which still is deeply anthropocentric) be capable of receive an ethic which respects the animals as ends in itselfs, as well as incorporates the existence of the moral relevance of non-human animals.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":146486998,"openaccessinfo":{"externalids":{"MAG":"2163642230","ACL":null,"DOI":"10.1344\/RBD2010.19.7708","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The productivity effects of agglomeration economies are often treated as endogenous in empirical work due to the potential for reverse causality. The extent to which these relationships are actually simultaneously determined, however, remains largely unobserved. This paper estimates panel data vector autoregressions for different sectors of the economy to test for bidirectional causality between productivity and both localization and urbanization economies. The aim is to address some key questions that will help to identify the extent of the endogeneity problem. Can we actually observe bidirectionality in the data? Does it feature more for some industries than for others? Is it more prevalent for localization or urbanization economies? The results show that agglomeration economies are not strictly unidirectional and that higher levels of productivity can induce growth in the scale of local urban and industrial environments. The paper discusses the difficulties that these issues pose for the estimation of agglomeration economies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":153880615,"openaccessinfo":{"externalids":{"MAG":"1992686927","ACL":null,"DOI":"10.1111\/j.1467-9787.2010.00676.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The paired Fluvisol and cereal samples in both the field screening and controlled experiments are reported to elucidate the soil\u2013crop relationship for As, Cd, and Pb in relation to changing contamination levels. Significant varietal differences in plant uptake were observed for crop type (barley, triticale) and the harvested part of the crop (oat shoots and grain). When parametrizing the stepwise regression models, the inclusion of soil properties often improved the performance of soil\u2013crop models but diverse critical soil parameters were retained in the model for individual metal(loid)s. The pH value was often a statistically significant variable for Cd uptake. For As and Pb, the more successful model fit was achieved using the indicators of quantity or quality of soil organic matter, but always with lower inherent model reliability compared to Cd. Further, a single correlation analysis was used to investigate the relationship between extractable metal concentrations in soil solution and their crop accumulation. For Cd, there were strong intercorrelations among single extractions, the NH4NO3 extraction stood out with perfect correlation with plant uptake in both experiments. For As and Pb, the CaCl2 and Na2EDTA solutions outperformed other single extractions and were the better choice for the assessment of depositional fluvial substrates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":236308525,"openaccessinfo":{"externalids":{"MAG":"3172119097","ACL":null,"DOI":"10.3390\/AGRONOMY11061180","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In many non-human primate species, a display of red by a female increases attraction behavior in male conspecifics. In two experiments, we investigate an analogous effect in humans, specifically, whether red on a woman's shirt increases attraction behavior in men. In Experiment 1, men who viewed an ostensible conversation partner in a red versus a green shirt chose to ask her more intimate questions. In Experiment 2, men who viewed an ostensible interaction partner in a red versus a blue shirt chose to sit closer to her. These effects were observed across participants' perceptions of their own attractiveness (Experiment 1) and general activation and mood (Experiment 2). Our findings suggest that red acts as a basic, non-lexical prime, influencing reproduction-relevant behavior in like manner across species. Copyright \u00a9 2010 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1,"unknown":3}},"corpusid":18372696,"openaccessinfo":{"externalids":{"MAG":"2007935763","ACL":null,"DOI":"10.1002\/EJSP.757","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nature-based solutions (NBSs) for risk reduction produce environmental effects that must be assessed to evaluate their performance. In a context of climate change and growing concern about the loss of biodiversity, indicators informing about ecosystem complexity, resilience and stability are required. NBS projects hardly ever include environmental monitoring programs and, at best, NBS performance is evaluated based on elementary indicators that provide poor information about ecosystem functions and services. Within the framework of the PHUSICOS (EU, H2020) project, a NBS approach is being applied to reduce the hydrometeorological risks (rock falls and snow avalanches) that threaten a transnational road and a very populated town in the Pyrenees range. In both cases, the planned actions are modifying soil and vegetation structure and functioning as well as the environmental services they provide. Here we present a set of soil and plant indicators designed to be included in the postoperation monitoring plan of both NBS projects. We provide a description and information about the range of values of every indicator measured in the study sites together with indications about analytical methods and sampling calendar. We discuss the trade-offs between monetary cost, expertise requirements and meaningfulness of the indicators.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":233910049,"openaccessinfo":{"externalids":{"MAG":"3127892206","ACL":null,"DOI":"10.3390\/SU13041913","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Microprocessors experience a wide range of dynamic variations, including voltage droops, temperature changes, and device aging, which vary across applications and systems. The necessity of ensuring correct operation even under infrequent worst-case conditions results in clock frequency (FCLK) or supply voltage (VCC) guardbands that degrade performance and increase energy consumption. In this paper, a research microprocessor core is described with resilient and adaptive circuits to mitigate dynamic variation guardbands for maximizing throughput or minimizing energy. The resiliency features consist of embedded error-detection sequentials (EDS) [1-4] and tunable replica circuits (TRC) [5] in conjunction with error-recovery circuits to detect and correct timing errors. A new instruction-replay error-recovery technique is introduced to correct errant instructions with low performance cost and implementation overhead. In addition, the microprocessor contains an adaptive clock controller based on error statistics to operate at maximum efficiency across a range of dynamic variations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":13020898,"openaccessinfo":{"externalids":{"MAG":"2016301038","ACL":null,"DOI":"10.1109\/ISSCC.2010.5433922","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The preventive effect on posttransfusional non-A, non-B hepatitis (PTH) of screening out HCV-Ab positive blood and the prevalence of HCV-Ab-positive donor blood were examined. The incidence of HCV-Ab-positivity in donor blood A was 0.9% and that in donor blood B was 1.35%. The mean ALT and guanase levels were 11.5 +\/- 5.8 and 0.58 +\/- 0.24 IU\/l in HCV-Ab negative blood and 17.3 +\/- 7.9 and 0.84 +\/- 0.23 IU\/l in HCV-Ab-positive blood. Both levels were significantly higher in HCV-Ab-positive blood. These differences were considered to be nonspecific, but there may be some relationship between the levels of ALT and guanase in donor blood and the HCV carrier status. After adoption the screening test for HCV-Ab positive blood, there was no case of a definite diagnosis of PTH, although 4 patients (6.6%) suspected of developing PTH. So, the incidence of PTH was clearly lower than the lowest incidence before adoption of this test. Therefore, we conclude that screening for HCV-Ab in donor blood should be routinely used for prevention of PTH.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20918020,"openaccessinfo":{"externalids":{"MAG":"307502544","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Picture Exchange Communication System (PECS) is a picture-based communication strategy used to teach communication skills to persons with developmental disabilities including autism. This article systematically reviews 13 published single-subject studies to examine the effectiveness of PECS, the effects of PECS on speech and problem behaviors, generalization beyond training conditions, and social validity of the intervention. The authors also calculated percentage of nonoverlapping data points for all participants to quantify, compare, and analyze results. Results indicate that PECS yielded increases in functional communication in all but 1 participant. Additionally, PECS decreased problem behaviors and increased speech in some individuals. A theoretical framework, analyses of methodologies, and implications for researchers and practitioners are discussed.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":145314749,"openaccessinfo":{"externalids":{"MAG":"2119234425","ACL":null,"DOI":"10.1177\/0741932509338354","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: Many inborn errors of metabolism (IEMs) may present as sudden infant death (SID). Nowadays, increasing numbers of patients with IEMs are identified pre-symptomatically by population neonatal bloodspot screening (NBS) programmes. However, some patients escape early detection because their symptoms and signs start before NBS test results become available, they even die even before the sample for NBS has been drawn or because there are IEMs which are not included in the NBS programmes. Objectives and Methods: This was a comprehensive systematic literature review to identify all IEMs associated with SID, including their treatability and detectability by NBS technologies. Reye syndrome (RS) was included in the search strategy because this condition can be considered a possible pre-stage of SID in a continuum of aggravating symptoms. Results: 43 IEMs were identified that were associated with SID and\/or RS. Of these, (1) 26 can already present during the neonatal period, (2) treatment is available for at least 32, and (3) 26 can currently be identified by the analysis of acylcarnitines and amino acids in dried bloodspots (DBS). Conclusion: We advocate an extensive analysis of amino acids and acylcarnitines in blood\/plasma\/DBS and urine for all children who died suddenly and\/or unexpectedly, including neonates in whom blood had not yet been drawn for the routine NBS test. The application of combined metabolite screening and DNA-sequencing techniques would facilitate fast identification and maximal diagnostic yield. This is important information for clinicians who need to maintain clinical awareness and decision-makers to improve population NBS programmes.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":1708046,"openaccessinfo":{"externalids":{"MAG":"2565798040","ACL":null,"DOI":"10.1159\/000443874","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.karger.com\/Article\/Pdf\/443874","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Myrothamnus flabellifolia is the only woody resurrection plant found in the world. It has a strong tolerance to drought and can survive long-term exposure to desiccated environments. However, few genes related to its drought tolerance have been functionally characterized and the molecular mechanisms underlying the stress tolerance of M. flabellifolia are largely unknown. In this study, we isolated a dehydration-inducible bHLH transcription factor gene MfbHLH145 from M. flabellifolia. Heterologous expression of MfbHLH145 enhanced the drought and salt tolerance of Arabidopsis. It can not only promote root system development under short-term stresses, but also improve growth performance under long-term treatments. Further investigation showed that MfbHLH145 contributes to enhanced leaf water retention capacity through the promotion of stomatal closure, increased osmolyte accumulation, and decreased stress-induced oxidative damage through an increase in antioxidant enzyme activities. These results suggest that MfbHLH145 may be involved in the positive regulation of stress responses in M. flabellifolia. This study provides insight into the molecular mechanism underlying the survival of M. flabellifolia in extreme dehydration conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248841693,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijms23105546","PubMedCentral":"9146472","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5546\/pdf?version=1652700477","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This is a summary of my 1994\u20131995 course on Algebraic Numbers. (Revised and improved on 1993\u2013 1994!) The background assumed is standard elementary number theory\u2014as found in my Level III course\u2014and a little (Abelian) group theory. Corrections and suggestions for improvement are welcome, and will be credited in future editions! I first learned algebraic number theory from Stewart & Tall's book ([3]) and this is an excellent account. However it's more abstract than the approach of this course and deals with general algebraic number theory while I deal mainly with the theory of quadratic fields. A book dealing mainly with quadratic fields is Cohn ([1]); I have incorporated many of the ideas in this book into this course, but this is a rather difficult book to read. I am grateful to Jeremy Bygott for corrections to and suggestions on a previous version, and to Paul Epstein for a further correction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118051950,"openaccessinfo":{"externalids":{"MAG":"182941901","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Global joint measurements of sea surface winds and currents are planned using satellite-based Doppler scatterometers operating in the Ka-band to achieve improved spatial resolution and retrieval accuracy. Still, the knowledge of sea surface Ka-band backscatter properties is poor, particularly, at high winds (>20 m s\u22121). Sea surface radar cross-section in the Ka-band, in contrast to that in the lower frequency Ku-\/X-\/C-\/L-bands, is likely more sensitive to sea spray, small-scale particles typically present at high winds. In this paper, tower-based field data collected by a continuous dual-co-polarized Ka-band radar during a strong offshore wind event (with wind speed reaching 33 m s\u22121) are analyzed. This katabatic wind event (\u224812 h long) was also recorded by supplementary wave, wind, and current sensors. At the wave fetch of \u22481 km, the maximum wavelength of observed offshore waves was \u224810 m. For such extremely young wind\u2013sea conditions, an apparent sea spray generation was observed during wind gusts. Radar measurements were performed at 20\u2218 and 45\u2218 incidence angles, mostly for cross- and up-wind azimuth look geometry. Based on these high wind measurements, the previously developed Ka-band empirical model is tested and compared with other published geophysical model functions. Dual-co-polarized measurements are used to infer resonant Bragg and non-Bragg scattering components and assess the short wind wave spectrum, which shows a clear tendency for saturation at high winds. The presence of sea spray signatures is apparent in the high-frequency tails of radar Doppler spectra, but their overall contribution to the Doppler centroid frequency is weak. Hence, the standard modulation transfer function approach developed for moderate winds is still applicable at high winds for interpreting the wave-induced Doppler velocity and inferring sea surface currents. These results can also be useful for understanding Doppler scatterometry measurements in tropical cyclones.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":247431718,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/rs14061348","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-4292\/14\/6\/1348\/pdf?version=1646913311","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"the growth of cyber attacks, information safety has become an important issue all over the world. Many firms rely on security technologies such as intrusion detection systems (IDSs) to manage information technology security risks. IDSs are considered to be the last line of defense to secure a network and play a very important role in detecting large number of attacks. However the main problem with today's most popular commercial IDSs is generating high volume of alerts and huge number of false positives. This drawback has become the main motivation for many research papers in IDS area. Hence, in this paper we present a data mining technique to assist network administrators to analyze and reduce false positive alarms that are produced by an IDS and increase detection accuracy. Our data mining technique is unsupervised clustering method based on hybrid ANT algorithm. This algorithm discovers clusters of intruders' behavior without prior knowledge of a possible number of classes, then we apply K-means algorithm to improve the convergence of the ANT clustering. Experimental results on real dataset show that our proposed approach is efficient with high detection rate and low false alarm rate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2864475,"openaccessinfo":{"externalids":{"MAG":"2151044728","ACL":null,"DOI":"10.5120\/19754-1048","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5120\/19754-1048","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Comment on: Philiippe Bachetta and Eric Van Wincoop, who in this paper aim is to assess the impact of financial liberalization in emerging markets on the dynamics of capital flows to these countries. By positing a cost of absorbing these flows, the authors explain how liberalization can give rise to an \"overshooting\" of capital inflows and asset prices. In addition, the authors examine whether incomplete information can give rise to a high degree of volatility in capital flows as well as to contagion. They also suggest that deviations in capital inflows from their steady-state levels can be used as a potential signal of future crises.(This abstract was borrowed from another version of this item.)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":151302090,"openaccessinfo":{"externalids":{"MAG":"169305514","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The global economy today needs global agreements to facilitate commerce not merely within a limited internal geographic area but internationally. And what has been lacking for years is a convention to provide for judgment recognition and enforcement that mirrors the reality of today's trade which with cyberspace and new technologies crosses borders instantaneously. The Hague Conference on Private International Law has been laboring in this field for almost 50 years, planting seeds from 1971. It is on the brink of completing such a convention which offers the promise of a treaty that incorporates sufficient flexibility to allow multiple legal systems to join and leaves room for growth with changing technologies and further harmonization of this area of law. \n \nThis Article provides the background on the negotiations through the years, especially the last 25 plus years, and considers how the instruments have changed in response to evolving dynamics in cross-border trade and internal changes at The Hague Conference. It provides a general introduction to the current draft that is to be negotiated at the final Diplomatic Session in June 2019 and considers issues remaining both generally and for the United States participation. It evaluates the convention and considers what changes it will bring domestically and internationally. And is answers the question of whether the world needs this global judgments convention and why the U.S. needs to be a willing partner.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":182906850,"openaccessinfo":{"externalids":{"MAG":"2945091802","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A cooperative study group consisted of 37 medical institutions evaluated the utility of pre- and post-operative chemotherapy with oral 5-FU by comparing with the historical controls of the patients treated with operation alone who were registered in Japanese Gastric Cancer List. Of 634 patients entered in this trial, 366 patients received curative operation at macroscopical stages II and III were studied as eligible cases. The relative 5-year survival at macroscopical stage II and III was 68.6% with 5-FU, significantly higher than 62.6% with operation alone (p < 0.05). Particularly, 5-year survival at macroscopical stage III was markedly different between 57.1% with 5-FU and 42.7% with operation alone. In order to make more effective comparison with the historical controls in this 1-arm trial, the background factors in 5-FU and control groups were matched in the ratio of 1:2 or 1:3 with respect to the following 4 factors: tumor site, S, N and macroscopical tumor type (by Kajitani's classification). As a result, the 5-year survival at macroscopical stages II and III was significantly higher with 5-FU (67.5%, 69.1%) than with operation alone (59.9%, 59.8%), and in particular this tendency was more marked at macroscopical stage III. These results suggest the usefulness of adjuvant chemotherapy in macroscopical stage III gastric cancer.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39477556,"openaccessinfo":{"externalids":{"MAG":"2414148745","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Ferromagnetic resonance (FMR) spectroscopy has become an increasingly useful tool for studying the magnetic properties of natural samples. Magnetite (Fe3O4) is the only magnetic mineral that has been well characterized using FMR. This limits the wider use of FMR in rock magnetism and paleomagnetism. In this study, we applied FMR analysis to a range of magnetic minerals, including greigite (Fe3S4), monoclinic pyrrhotite (Fe7S8), magnetically non\u2010interacting titanomagnetite (Fe3\u2010xTixO4), and synthetic magnetite chains to constrain interpretation of FMR analysis of natural samples and to explore applications of FMR spectroscopy. We measured the FMR signatures of a wide range of well\u2010characterized samples at the X\u2010 and Q\u2010bands. FMR spectra were also simulated numerically to compare with experimental results. The effects of magnetic anisotropy, mineralogy, domain state, and magnetostatic interactions on the FMR spectra are discussed for all studied minerals. Our experimental and theoretical analyses of magnetically non\u2010interacting tuff samples and magnetically interacting chains enable quantitative assessment of contributions of magnetostatic interactions and magnetic anisotropy to the FMR spectra. Our results also indicate that intact magnetosomes are a unique system with distinct FMR signatures. While FMR analysis is useful for characterizing magnetic properties of natural samples, care is needed when making interpretations because of overlaps in a range of FMR signatures of different magnetic minerals with different magnetic properties. Our analyses will help to constrain such interpretations in rock magnetic studies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":40097159,"openaccessinfo":{"externalids":{"MAG":"1914560065","ACL":null,"DOI":"10.1029\/2012GC004063","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper examines the retail price structure of saffron currently marketed in the Spanish market, with special emphasis on the assessment of the region of origin and its certification as tools of differentiation. The motivation lies on the search for effective marketing tools for Jiloca saffron (Aragon) that in turn may contribute to preserve this traditional agricultural sector threatened by progressive abandonment. An hedonic price regression is estimated for this purpose, where the functional form is empirically determined. The prices and product characteristics have been collected from labels of saffron references either found on the shelves of representative retail shops in the main city of Aragon (Zaragoza) or on the internet shopping services that the main Spanish distribution chains offer. Results show that higher prices are attached for saffron distributed at supermarkets and Gourmet shops, marketed in threads, packaged in glass, and which carries a brand owned by a processor specialized in the processing and marketing of saffron. Currently, the recognition of Jiloca origin does not carry a premium, contrary to what happens to La Mancha, whilst the Protected Designation of Origin reinforces the economic value of La Mancha origin.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":53469117,"openaccessinfo":{"externalids":{"MAG":"2071021678","ACL":null,"DOI":"10.5424\/SJAR\/2009072-421","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Job rotation is a work organisation strategy used to reduce work-related exposures and musculoskeletal complaints, yet evidence for the efficacy of the approach is weak. Mismatch between job rotation and company needs, lack of full implementation, lack of exposure variation in included tasks and failure to assess variation may underlie inconclusive research findings to date. The study aims to develop a job rotation with company stakeholders, perform a process evaluation of the implementation, and determine the extent to which the intervention improves the physical and psychosocial work environment, indicators of health, gender and social equality among workers and production quality and resilience. Methods and analysis Approximately 60 production workers at a Swedish commercial laundromat will be recruited. Physical and psychosocial work environment conditions, health, productivity and gender and social equality will be assessed pre and post intervention, using surveys, accelerometers, heart rate, electromyography and focus groups. A task-based exposure matrix will be constructed, and exposure variation estimated at the level of the individual worker pre and post intervention. An implementation process evaluation will be conducted. Job rotation efficacy will be assessed in terms of improvement in work environment conditions, health, gender and social inequality, and production quality and resilience. This study will provide novel information on the effects of the job rotation on physical and psychosocial work environment conditions, production quality and rate, health and gender and social inequality among blue-collar workers in a highly multicultural workplace. Ethics and dissemination The study received approval from the Swedish Ethical Review Authority (reference number 2019-00228). The results of the project will be shared directly with the employees, managers and union representatives from the participating company, other relevant labour market stakeholders and with researchers at national and international conferences and via scientific publication. Trial registration number The study is preregistered with the Open Science Framework (https:\/\/osf.io\/zmdc8\/).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":258639908,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjopen-2022-067633","PubMedCentral":"10186472","ArXiv":null},"license":"CCBYNC","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/13\/5\/e067633.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A self-referenced technique for measuring the phase of individual optical frequency comb lines is demonstrated. Spectral frequency shear is obtained from sum frequency generation of a signal comb with wavelength separated reference tones.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34357627,"openaccessinfo":{"externalids":{"MAG":"2096072720","ACL":null,"DOI":"10.1364\/CLEO.2009.CMY6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To the Editor:\u2014 In my letter to the Editor regarding human antirabies serum I pointed out that humans are known to have survived clinical rabies, proved by laboratory tests, when they received blood transfusions from donors recently actively immunized against rabies. Since the publication of my letter, I have received a number of requests for specific literature references supporting this assertion. Herewith are the published reports on which my statement is based.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":71456066,"openaccessinfo":{"externalids":{"MAG":"1975363794","ACL":null,"DOI":"10.1001\/JAMA.1966.03110030118047","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Soybean [Glycine max (L.) Merrill] is the main agricultural product export of Brazil. Therefore, it is important studies that contribute to the mitigation of the effects that might cause a decrease in income and depreciation of the quality of this oleaginous plant, as the occurrence of pests and diseases, problems with soil fertility and climatic adversities, among others. It is known that plants differ in their ability to absorb silicon (Si) and are therefore classified differently. The influence of vegetation on Si in the development of soybean plants is still little known, and there are few studies described in the literature. Facing this, the objective of this work was to evaluate the response of soybean plants to variable dosage of silicon in the plantation, through agronomical characteristics of the plants in the field. The experimental design was a completely randomized block (CBD), with three replicates, eleven treatments with the following doses of silicon (0, 50, 100, 150, 200, 250, 300, 350, 400, 450 and 500 kg ha - 1 ) in the soybean planting, cultivating BRS MG 68 Vencedora. Doses of silicon used did not provide significant increases in seed yield, weight of a thousand seeds, and number of seeds per vegetable, but the number of vegetables per plant, plant height and time of insertion of the first vegetable increased significantly with higher doses. Application of silicon did not have phytotoxic effects on the soybean plant.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":133414819,"openaccessinfo":{"externalids":{"MAG":"2605699592","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\nPulmonary neuroendocrine tumors, including small cell lung cancer (SCLC) and non-small cell neuroendocrine tumor (NSCLC-NET), have obvious heterogeneity. The comparison between SCLC and NSCLC-NET, and prognostic nomogram of resected NSCLC-NET have not been performed.\n\n\nMethods\nWe retrieved data from SEER database. The incidence and prognostic factors were compared between SCLC and NSCLC-NET. By Cox regression, we constructed prognostic nomogram of resected NSCLC-NET. The nomogram was evaluated by ROC, calibration plot and decision curve analysis (DCA) and compared with 8th TNM staging system. A Chinese cohort was used for external validation.\n\n\nResults\nThe age-adjusted incidence of SCLC declined after 1991 but the incidence of NSCLC-NET continuously rose. Patients with typical carcinoid had the best prognosis in both overall survival and lung cancer specific survival, followed by atypical carcinoid, large cell neuroendocrine tumor and SCLC after operation. Patients receiving sleeve resection in NSCLC-NET had longer survival but segmental resection was more recommended in SCLC. High-smoking index was associated with worse overall survival in both SCLC and NSCLC-NET. Histological subtype, age, surgery type, N, M stage and chemotherapy were independent prognostic factors and used to construct prognostic nomogram of resected NSCLC-NET. The nomogram performed well with good discrimination, calibration and clinical usefulness, which was validated by a Chinese cohort (1, 3, 5-year AUC: SEER cohort 0.873, 0.901, 0.875; Chinese cohort 0.867, 0.892, 0.874). Compared to the 8th staging system, the nomogram had higher C-index (0.87 vs 0.728, P\u00a0<\u00a00.001), clinical usefulness, increasing AUC value over time and improved 68%.\n\n\nConclusion\nThe prognostic nomogram of resected NSCLC-NET performed better than the 8th TNM staging system. It may have certain value in risk stratification and survival prediction of patients with resected NSCLC-NET and help clinicians to take measures for high-risk patients in advance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245370648,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-1116500\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-1116500\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Quite a few of persons often fall into an error that ISO has happened an additional work at construction sites. Supervision works, however, are carried out in compliance with 'Guidelines for the Supervision Works' which is including most ISO Requirements. Additional requirements needed for the supervision works are not many. This study has studied on the ISO application of supervision works in relation to, 1) ISO 9001 & KS A 9001 Quality Management System Basic Model, 2) The Process of Railway Construction Work Supervision Quality Management Plan, 3) Supervision Work Performance Guide Book(2005) & KS A 9001(2001) Standard, at the railway construction sites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108047091,"openaccessinfo":{"externalids":{"MAG":"163544575","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The major research question in this paper is whether improved corporate political disclosure and accountability lead to improved stock market and financial performance. To explore this question, the paper first examines the corporate financial performance of companies ranked by the Center for Political Accountability (CPA), and finds no significant relationship between a company's ranking on the CPA and its financial and stock market performance. The paper hypothesizes that the reason for the lack of a relationship is because the CPA ranking system is itself flawed, insofar as the criteria used to evaluate corporate political accountability exclude important elements of political activity and potential corruption. To test this hypothesis, the paper adds revised criteria that include important aspects of corporate political activities and accountability. Using these revised criteria, the authors then re-evaluate and re-rank the 196 corporations in the top two quintiles of the S&P 500. The results show that, so long as appropriate criteria are used to measure corporate political disclosure and accountability practices, there is indeed a positive relationship between corporate political disclosure and accountability practices and improved financial and stock market performance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":203238426,"openaccessinfo":{"externalids":{"MAG":"2970296505","ACL":null,"DOI":"10.22495\/jgr_v8_i3_p6","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.22495\/jgr_v8_i3_p6","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper describes the design, fabrication, and testing of microfluidic devices enabled by electrodes embedded vertically in the side walls of SU-8 microchannels. With vertical electrodes on the side walls, one can generate higher lateral electrical fields uniform along the vertical direction in the channel (perpendicular to the substrate). By designing the electrode shapes and configurations, uniform and nonuniform electrical fields in the lateral (planar) directions can be applied to manipulate flow or particles in microchannels for switching or sorting applications. The uniform field is demonstrated in a magnetohydrodynamic (MHD) microfluidic device for directing cells to different channel outlets while the nonuniform field is demonstrated in the generation of dielectrophoresis (DEP) forces for microbead focusing. Metal electrodes are fabricated by electroplating to form vertical electrodes aligned with the channel walls. The multilayer SU-8 lithography technique enables the four walls of the channel to be all SU-8. The thin precoated SU-8 layer on the substrate improves structure integrity of the SU-8 microchannels. The mechanical flexibility of PDMS compensates for the surface nonuniformity from the previous patterning steps to conformably cap the channel. The ability to integrate versatile electrodes design broadens the realm of electrical control and sensing for microfluidic applications","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":695875,"openaccessinfo":{"externalids":{"MAG":"1972629638","ACL":null,"DOI":"10.1109\/JMEMS.2006.889530","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chiral graphene quantum dots were prepared by acidic exfoliation and oxidation of graphite, dialysis, and esterification with enantiomerically pure (R) or (S)-2-phenyl-1-propanol. Circular dichroism studies support the formation of supramolecular aggregates with pyrene molecules, where a transfer of chirality occurs from the chiral graphene quantum dots to the pyrene.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34661307,"openaccessinfo":{"externalids":{"MAG":"2176727280","ACL":null,"DOI":"10.1039\/c5cc08890a","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/eprints.ucm.es\/id\/eprint\/41682\/1\/CC-2016-52-665-preprint.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper explores how London was defined by the new interest in walking in the long eighteenth century. As Michel de Certeau famously wrote central to understanding the 'practices of everyday life' which create the urban milieu was the act of walking. However, such a notion can traced back beyond the modern fl\u00e2neur to the eighteenth-century when perambulation was also seen as an important mode in the comprehension and experience of the city. This paper focuses on the periphery of the capital to consider how the outer London landscapes were understood by contemporaries through the act of strolling in their green spaces. It draws on a large body of urban literature and visual evidence, in the form of topographical prints, is also used to establish the significance of this new leisure activity in contributing to the character and culture of the outskirts and its architecture as a distinct metropolitan zone spatially and metaphorically. This was a landscape created by movement and its accessibility from the centre, by a variety of means of transport, among which pedestrianism was of crucial importance.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":134281512,"openaccessinfo":{"externalids":{"MAG":"2762181751","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: The aim was to investigate the effectiveness of pegylated liposomal doxorubicin (PLD), beta-carotene, and a combination of PLD and beta-carotene on JAR and JEG-3 human choriocarcinoma (CC) cell lines for the treatment of CC. Material and Methods: JAR and JEG-3 cells were cultured. PLD and beta-carotene trial groups were determined with different doses (for single drug trial; PLD 1, 2, 5 \u03bcg\/mL and beta-carotene 1, 5, 10 \u03bcg\/mL, and for combined drug trial; all PLD doses combined with beta-carotene 5 \u03bcg\/mL). Drugs were administered to cultures simultaneously, and 72 hours later the cells were detached using trypsin-ethylenediamine tetraacetic acid solution. The percentage of apoptotic cells was determined by flow cytometry after annexin V staining. One set of the supernatant was collected before trypsin application to investigate beta-human chorionic gonadotropin (\u03b2-hCG) and hyperglycosylated hCG (H-hCG) levels. Statistical analyses of the apoptotic ratios were performed using Shapiro-Wilk, Kruskal-Wallis and Mann-Whitney U tests. Results: Apoptosis increased in JAR and JEG-3 cultures after treatment with all doses of PLD (p<0.05). A single application of each beta-carotene dose increased apoptosis in JAR cells (p<0.05) but had no apoptotic effects on JEG-3 cells. In the PLD and beta-carotene combination group, apoptosis increased in both JAR and JEG-3 cells (p<0.05). Conclusion: To our knowledge, this is the first investigation of the effectiveness of PLD, beta-carotene, and PLD + beta-carotene combination therapy in two different CC cell lines. PLD is a promising chemotherapeutic drug, and beta-carotene can be used as a novel non-chemotherapeutic agent for treatment of CC. Based on the results of this study, vitamin A supplementation may have promise as a preventive measure. However, these data need support from animal experiments and clinical trials.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220371460,"openaccessinfo":{"externalids":{"MAG":"3040529283","ACL":null,"DOI":"10.4274\/jtgga.galenos.2020.2019.0199","PubMedCentral":"7495128","ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4274\/jtgga.galenos.2020.2019.0199","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Synopsis Massive tholeiitic metadolerite dykes cutting Dalradian metasediments of the Jura Quartzite formation of Jura and Islay are comparable in major and trace element composition to other Dalradian metabasic rocks of the SW Highlands. Trace element geochemistry indicates that these dykes are usually less evolved than most of the overlying metabasaltic sills and volcanics in mainland Argyllshire, consistent with their likely role as feeders to the sills and volcanics. Metamorphic assemblages in the Jura dykes and in greenschist facies metabasic rocks elsewhere in the SW Highlands are identical, and the metamorphic fluid phase behaviour in both groups of rocks appears to have been similar. Reconstruction of pre-tectonic dyke geometries suggests that the dykes were intruded perpendicular to bedding as a NW\u2013SE group responding to NE\u2013SW crustal tension (contemporaneously with extrusion of the volcanic rocks). This evidence, together with that of sedimentary-basin and syndepositional-fault geometries, may indicate changes in the direction of relative crustal tension from NE\u2013SW to NW\u2013SE and back to NE\u2013SW during oblique or strike-slip (transtensional) rifting of a subsiding continental margin during Argyll Group times. The dominance of sill intrusion relative to dyke intrusion in SW Highland metabasaltic rocks is analogous to the intrusive behaviour of basic magma in modern deep rifted sedimentary basins such as the present day Gulf of California. Expulsion of water from adjacent sediments and establishment of large-scale hydrothermal systems may explain the abundance of post-crystallisation spilitic alteration of SW Highland metabasaltic rocks.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129889514,"openaccessinfo":{"externalids":{"MAG":"2045739119","ACL":null,"DOI":"10.1144\/sjg20020257","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nIn this study we determined the incidence and direct inpatient and outpatient costs of systemic fungal infections (candidiasis, aspergillosis, cryptococcosis, histoplasmosis) in 1998.\n\n\nMETHODS\nUsing primarily the National Hospital Discharge Survey (NHDS) for incidence and the Maryland Hospital Discharge Data Set (MDHDDS) for costs, we surveyed four systemic fungal infections in patients who also had HIV\/AIDS, neoplasia, transplant, and all other concomitant diagnoses. Using a case-control method, we compared the cases with controls (those without fungal infections with the same underlying comorbidity) to obtain the incremental hospitalization costs. We used the Student's t-test to determine significance of incremental hospital costs. We modeled outpatient costs on the basis of discharge status to calculate the total annual cost for systemic fungal infections in 1998.\n\n\nRESULTS\nFor 1998, the projected average incidence was 306 per million US population, with candidiasis accounting for 75% of cases. The estimated total direct cost was $2.6 billion and the average per-patient attributable cost was $31,200. The most commonly reported comorbid diagnoses with fungal infections (HIV\/AIDS, neoplasms, transplants) accounted for only 45% of all infections.\n\n\nCONCLUSIONS\nThe cost burden is high for systemic fungal infections. Additional attention should be given to the 55% with fungal disease and other comorbid diagnoses.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9491118,"openaccessinfo":{"externalids":{"MAG":"2012050459","ACL":null,"DOI":"10.1046\/J.1524-4733.2002.51108.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Free tissue transfer has evolved from muscle flaps to fasciocutaneous flaps. Dissection of the intramuscular course of feeding vessels is technically challenging. Simulation-based microsurgery skills acquisition is moving toward nonliving training models. Living porcine model or human cadavers are currently cost-ineffective methods for the early learning curve in teaching intramuscular dissection. The aim of this study was to validate an inexpensive ex vivo porcine model simulating harvest of the deep inferior epigastric artery perforator (DIEAP) flap, specifically including perforator intramuscular dissection. Methods: An initial needs analysis and anatomical dissections (characteristics of vascular anatomy) established the necessity and surgical design (step-by-step) of the ex vivo DIEAP flap harvesting model. A pilot study utilizing objective assessment methodology (time to complete flap raising and hand motion analysis) demonstrated the surgeons' performance. A detailed feedback questionnaire was used to assess the participants' perception of this model. Results: Fifty-seven participants completed the initial needs analysis. Fifteen pork bellies were dissected and the vascular anatomical characteristics of the inferior epigastric vessels are presented. Eight surgeons performed the step-by-step flap design demonstrating construct validity in flap raising and intramuscular dissection. All surgeons completed the ex vivo DIEAP harvesting and they recommend this model as the first step in training for intramuscular dissection. Conclusions: The pork belly simulation is a cheap, easy, ethically considerate, and high-fidelity simulation model for intramuscular dissection for the DIEAP free flap. This study guides future validation trials to explore if the absence of physiological blood flow affects skills acquisition in the intramuscular dissection learning curve. The pork belly could be the first step in perforators dissection before progressing to the in vivo porcine model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4529563,"openaccessinfo":{"externalids":{"MAG":"2790243743","ACL":null,"DOI":"10.1097\/GOX.0000000000001674","PubMedCentral":"5865931","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Past research has extensively studied individuals' knowledge-sharing behavior. Identifying the effective mechanisms that motivate individuals to share their valuable knowledge has become an important issue and a major challenge for researchers and practitioners. Past studies fail to consider the readiness of conversion of motivational mechanism to economic benefits of knowledge sharing on knowledge sharing behavior. This study develops a theoretical model of the convertibility of economic benefits that integrates the calculative-based mechanism (CBM) modified from organizational reward systems and the relational-based mechanism (RBM) founded on social interaction to explain knowledge sharing behavior. The research will be conducted by a field study in collaboration with a district hospital to secure the survey data. The objective of this study is to help answer the following research questions. 1. How does the CBM, which incorporates the construct of organizational reward systems, facilitate knowledge sharing behavior? 2. How does the RBM, which incorporates the construct of deposits, withdrawals, and relationship account balance, facilitate knowledge sharing behavior? 3. Against the benchmark of the CBM, does the addition of the RBM give a better explanation of individual knowledge sharing behavior?","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88507640,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"All\u2010solid\u2010state batteries (ASSBs) with silicon anodes are promising candidates to overcome energy limitations of conventional lithium\u2010ion batteries. However, silicon undergoes severe volume changes during cycling leading to rapid degradation. In this study, a columnar silicon anode (col\u2010Si) fabricated by a scalable physical vapor deposition process (PVD) is integrated in all\u2010solid\u2010state batteries based on argyrodite\u2010type electrolyte (Li6PS5Cl, 3 mS cm\u22121) and Ni\u2010rich layered oxide cathodes (LiNi0.9Co0.05Mn0.05O2, NCM) with a high specific capacity (210 mAh g\u22121). The column structure exhibits a 1D breathing mechanism similar to lithium, which preserves the interface toward the electrolyte. Stable cycling is demonstrated for more than 100 cycles with a high coulombic efficiency (CE) of 99.7\u201399.9% in full cells with industrially relevant areal loadings of 3.5 mAh cm\u22122, which is the highest value reported so far for ASSB full cells with silicon anodes. Impedance spectroscopy revealed that anode resistance is drastically reduced after first lithiation, which allows high charging currents of 0.9 mA cm\u22122 at room temperature without the occurrence of dendrites and short circuits. Finally, in\u2010operando monitoring of pouch cells gave valuable insights into the breathing behavior of the solid\u2010state cell.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225482169,"openaccessinfo":{"externalids":{"MAG":"3043824166","ACL":null,"DOI":"10.1002\/aenm.202001320","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/aenm.202001320","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"THE ACUTE symptoms of lead poisoning were recognized by Nikander as early as the second century, BC, and they were correctly attributed to \"cerussa\" (white lead). 1 However, the \"Devonshire colic\" of 1724 was initially thought to be an epidemic pestilence. Tronchin correctly identified lead in the drinking water of Amsterdam as the cause of the epidemic colic of that city in 1757, and Baker showed ten years later that the cider made in Devon contained large amounts of lead, which produced the colic. 1 During the 200 years since, the literature has been replete with studies of lead poisoning, and although the industrial sources have been largely eliminated, the home brewing of wine 2,3 or whiskey 4,5 has continued to be a considerable source of chronic lead absorption in some areas. There has been universal agreement about the acute symptoms of plumbism, but the nature of the delayed effects remains controversial. In 1863","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":783733,"openaccessinfo":{"externalids":{"MAG":"2121871320","ACL":null,"DOI":"10.1001\/ARCHINTE.118.1.17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Harmonic motion imaging (HMI) is a radiation-force-based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting oscillatory displacement denoting the underlying tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radio-frequency signals using a 1-D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated at a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":9724235,"openaccessinfo":{"externalids":{"MAG":"1677634964","ACL":null,"DOI":"10.1109\/TUFFC.2015.007113","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although ICT resources are commonly expected to produce uniform benefits, they are necessarily employed within pre-existing contexts of educational and social activity, and the outcome in terms of both pattern of use and learning depends on how they fit in with these. As a result, the same technology or software may have unexpectedly diverse effects, according to specific setting. If the object is to exercise control over outcome, then the conditions of use need to be planned for within the design and implementation of the technology. In order to do this, it is crucial that research gathers data on how outcomes are affected by the interplay between technology and context. This raises questions about the methods that would be appropriate for the conduct and dissemination of such research. These points are discussed in relation to three studies, one each at primary, secondary and university levels of education.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":822864,"openaccessinfo":{"externalids":{"MAG":"1532527488","ACL":null,"DOI":"10.1046\/j.0266-4909.2001.00178.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/discovery.ucl.ac.uk\/1548222\/1\/Tolmie2001Examining235.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The monitoring of wound\u2010healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non\u2010invasive and reliable observation of morphological changes in wound healing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":2}},"corpusid":28556527,"openaccessinfo":{"externalids":{"MAG":"2125235198","ACL":null,"DOI":"10.1111\/srt.12077","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There is much interest in understanding decision-making processes that determine funding outcomes for health interventions. We use classification and regression trees (CART) to identify cost-effectiveness thresholds and hierarchies in the determinants of funding decisions. The hierarchical structure of CART is suited to analyzing complex conditional and nonlinear relationships. Our analysis uncovered hierarchies where interventions were grouped according to their type and objective. Cost-effectiveness thresholds varied markedly depending on which group the intervention belonged to: lifestyle-type interventions with a prevention objective had an incremental cost-effectiveness threshold of $2356, suggesting that such interventions need to be close to cost saving or dominant to be funded. For lifestyle-type interventions with a treatment objective, the threshold was much higher at $37,024. Lower down the tree, intervention attributes such as the level of patient contribution and the eligibility for government reimbursement influenced the likelihood of funding within groups of similar interventions. Comparison between our CART models and previously published results demonstrated concurrence with standard regression techniques while providing additional insights regarding the role of the funding environment and the structure of decision-maker preferences.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4036458,"openaccessinfo":{"externalids":{"MAG":"2309655609","ACL":null,"DOI":"10.1177\/0272989X16638846","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tertiary succesion of the Los Pozuelos creek (Vinchina Basin): Its stratigraphic and paleogeographic importance for the Andean foreland. The description and interpretation of a thick Tertiary sedimentary succession cropping out along the Los Pozuelos creek, northern part of the Vinchina basin is presented here. The sedimentary column was divided into eight stratigraphic sections (SE), including the Vallecito Formation (SE1, aeolian; SE2, fluvial-aeolian interaction), the lower member of the Vinchina Formation (SE3, ephemeral sandy fluvial systems; SE4, braided to anastomosed fluvial systems), the upper member of the Vinchina Formation (SE5 and SE6, amalgamated sandy-gravel braided and high sinuosity fluvial systems) and the lower member of the Toro Negro Formation (SE7, confined gravelly to sandy braid plain; SE8, gravelly to sandy anastomosing fluvial systems). The unconformity between the Vallecito and Vinchina formations represents a major change in the evolution of the Andean foreland basin. SE3 and SE4 deposits (early transpressive retroarc stage) are continuous and homogeneous along strike, while SE5 and SE6 deposits (late transpressive retroarc stage) are not; indicating that uplifted basement blocks partitioned the foreland into isolated depocenters (broken-foreland basin). Rocks belonging to SE7 and SE8 show the complex relationship between the fold and thrust belt and the basement blocks. Facies changes and decreasing grain-size in a North to South direction recorded in the upper member of the Vinchina Formation when comparing the northern exposures (Los Pozuelos creek) and the central section along the La Troya River indicate that the Toro Negro Range acted as a local positive element since the early Miocene.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129585233,"openaccessinfo":{"externalids":{"MAG":"1560883800","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Development policies for fishery resources within the Mekong River Basin are increasingly divided between aquaculture and capture fisheries. The modern production orientation of aquaculture has been adopted by government and NGOs and justified by the rhetoric of poverty alleviation and rural development. In contrast, capture fisheries has been subjugated as an activity that reaffirms the dependency of the rural poor on natural resources. This paper critically analyses the division between aquaculture and capture fisheries in Cambodia, Thailand and Lao PDR by tracing the emergence and influence of 'development narratives' used to justify contemporary policy and practice.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55103832,"openaccessinfo":{"externalids":{"MAG":"2048129150","ACL":null,"DOI":"10.1017\/S0022463408000349","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The insulin signaling pathway is composed of a large number of molecules that positively or negatively modulate insulin specific signal transduction following its binding to the cognate receptor. Given the importance of the final effects of insulin signal transduction, it is conceivable that many regulators are needed in order to tightly control the metabolic or proliferative functional outputs. MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively modulate gene expression through their specific binding within the 3\u2032UTR sequence of messenger RNA (mRNA), thus causing mRNA decoy or translational inhibition. In the last decade, miRNAs have been addressed as pivotal cellular rheostats which control many fundamental signaling pathways, including insulin signal transduction. Several studies demonstrated that multiple alterations of miRNAs expression or function are relevant for the development of insulin resistance in type 2 diabetes (T2D); such alterations have been highlighted in multiple insulin target organs including liver, muscles, and adipose tissue. Indirectly, miRNAs have been identified as modulators of inflammation-derived insulin resistance, by controlling\/tuning the activity of innate immune cells in insulin target tissues. Here, we review main findings on miRNA functions as modulators of insulin signaling in physiologic- or in T2D insulin resistance- status. Additionally, we report the latest hypotheses of prospective therapies involving miRNAs as potential targets for future drugs in T2D.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53712111,"openaccessinfo":{"externalids":{"MAG":"2900914388","ACL":null,"DOI":"10.3390\/ijms19123705","PubMedCentral":"6321520","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1422-0067\/19\/12\/3705\/pdf?version=1542879469","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to determine the relationship of two types of social support (emotional and instrumental) and two types of social undermining (critical appraisal and isolation) with five categories of alcohol, drug, or mental disorders (ADM; any mood, any anxiety, any substance abuse, any disorder, and two or more disorders) in 169 American Indian women presenting for primary care at an Indian Health Service facility. Social support and social undermining are often treated as opposite poles, but in fact they are distinct factors with independent effects. The findings illustrate that social support and undermining variables have a significant relationship with ADM outcomes even when controlling for confounding demographic variables. Any substance abuse was associated with all four social variables, while two or more disorders were associated with instrumental support and isolation. Any anxiety (isolation), any mood (critical appraisal), and any disorder (isolation) were each associated with one social variable. Overall, social undermining appears to have a stronger relationship with mental health than with social support.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29630725,"openaccessinfo":{"externalids":{"MAG":"2084940594","ACL":null,"DOI":"10.1080\/10810730601152771","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"24 Background: After curative local therapy, thousands of men will have rising PSA as an early indicator of recurrent prostate cancer. For them, no standard of care exists, and concern over serious side effects of androgen deprivation (ADT) makes delaying ADT common. We tested Prostate Health Cocktail (PHC), which contains vitamins D & E, saw palmetto, lycopene, green tea and soy extracts, in this population, to see whether it could induce PSA declines.\n\n\nMETHODS\nEligible men had rising PSA with doubling time (DT) 3-36 months, with no evidence of metastases on CT and bone scans. After IRB approval, 28 men were treated with PHC 3 capsules PO daily for 4 week cycles. PSA was repeated after the first cycle, then every 2 cycles with imaging only as clinically indicated; the primary endpoint was PSA decline. PSA progression was defined as 25% increase and absolute increase of 5 ng\/mL or return to baseline. Circulating tumor cells (CTCs) were measured at baseline and after 3 cycles using parylene membrane filters.\n\n\nRESULTS\nThe median age was 67 (range 54-84) and baseline PSA was 2.9 ng\/mL (1.1-53.2); the median number of cycles was 6 (1-13). Stable PSA was the best response for 23\/28 men (83%) and 8\/27 men (29.6%) had a PSA decline (1.1%-29.4% maximum decrease). 47% stopped therapy for progression with median time to progression=9.2 months. There was no association between Gleason score or baseline PSA, vitamin D or selenium level and PSA decline. CTCs were detected in 5 of the first 23 subjects. The median PSA for these men was 2.77 ng\/mL (range 1.63-16.8). There was no significant change in testosterone or DHT during treatment. Median PSA DT at baseline was 7.8 months (range 3-36). One patient had grade 3 transaminitis in the setting of alcohol consumption, otherwise toxicities were limited to grade 1 or 2 hypercalcemia(1), hyperkalemia(2), hyperglycemia(4), flatulence(4), other GI(5), and rash(1).\n\n\nCONCLUSIONS\nPHC demonstrated activity in men with biochemically recurrent prostate cancer, resulting in PSA declines in nearly a third of cases, and was not associated with changes in serum androgens or significant toxicities. For the first time, we are reporting that circulating tumor cells can be detected in men with biochemical recurrence using filter technology.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46169815,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report on a newborn girl with holoprosencephaly, microcephaly, absent right radius, and other anomalies with an 46,XX,i(18q) chromosome constitution. This is the first report of an i(18q) in syndromal alobar holoprosencephaly.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29018610,"openaccessinfo":{"externalids":{"MAG":"1999672481","ACL":null,"DOI":"10.1002\/AJMG.1320390104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Allergic rhinitis and asthma share common epidemiological features and inflammatory processes. The aim of the present study was to document the influence of natural allergen exposure in exhaled NO (eNO) and in spirometric parameters of patients with seasonal allergic rhinitis(SAR) and to investigate the differences among subjects with positive versus negative bronchial provocation to metacholine(BPMch).Twenty-six non-smoking patients (13F\/13M; mean age 28.4ys) with a documented history of SAR, 15 healthy, non-atopic(6F\/9M; mean age 37.1ys) and 6 non-symptomatic atopic subjects (3F\/3M; mean age 36.5ys) were studied. At the first visit during pollen season each subject filled symptom-score card, underwent eNO and nasal NO (nNO) measurements and spirometry. BPMch was performed within the next 10 days. At the second visit out of pollen season, all measurements but BPMch were repeated. Control subjects underwent eNO and nNO measurements.eNO was significantly increased during pollen season in BPMch positive vs BPMch negative(46.22\u00b132.60 vs 17.81\u00b112.67, p=0.014) and vs non-atopic controls(11.40\u00b15.84, p<0.001) as well as atopic controls(13.56\u00b15.34, p=0.001). No difference was detected out of pollen season in both patients' groups. nNO values were increased only in BPMch(+) group compared to both control groups in pollen season (vs non-atopics p=0.002, vs atopics p=0.002) and only vs non-atopics out of season, p=0.004. Regression analysis has shown that the difference in FEF25-75 values (off season-in season) is a predictor of positive BPMch .eNO is markedly increased in BPMch patients with allergic rhinitis while mid-expiratory flow may represent an early marker of lower airway involvement in respiratory allergy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15915417,"openaccessinfo":{"externalids":{"MAG":"2112337330","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Medical reports in Gynecology have to consider the evaluation of organic diagnosis as well as connected psychical disorders. It has to be examined if psychical insults have led to dysfunction in the genital system. A typical example is hypothalamic amenorrhea as a sequel of extreme stress or chance of surroundings. Frequent lesions in the urinary system due to endometriosis, change of site, tumours and chronic inflammation of the female genital system often require a urological as well as a gynecological examination. Severity and duration of complaint, tendency to recur and the necessity of clinical treatment are essential factors in the assessment of the degree of disability. Examples of medical reports are shown and the limits of modified professional discretion are pointed out.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19808795,"openaccessinfo":{"externalids":{"MAG":"2412546135","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Patient: Male, 55-year-old Final Diagnosis: Aphakia Symptoms: Decreased visual acuity \u2022 photophobia Medication:\u2014 Clinical Procedure: Lens implantation \u2022 vitrectomy Specialty: Ophthalmology Objective: Management of emergency care Background: A safer and more delicate approach is required for the management of a post-traumatic aphakia and subtotal aniridia. Case Report: A 55-year-old man was referred to our clinic with symptoms of decreased vision (hand motion) and photophobia in his right eye. This patient had previously undergone pars plana vitrectomy (PPV) for the management of blunt ocular trauma in the same eye. He was being treated with topical antihypertensives, due to silicone oil-induced glaucoma. On presentation, the best corrected visual acuity (BCVA) in his right eye was 20\/40 and the intraocular pressure (IOP) in the same eye was 20 mmHg. Slit lamp examination of his right eye showed aphakia, aniridia, and some silicone oil droplets (fish eggs) following silicone oil extraction. His corneal endothelium and thickness were within normal limits. Dilated fundoscopic examination of the right eye revealed that the retina was attached with no signs of proliferative vitreoretinopathy (PVR). An artificial iris intraocular lens (IOL) was implanted, along with 4-point scleral fixation in conjunction with Gore-Tex sutures. After 6 months, the BCVA in his right eye was 20\/40 and he had no symptoms of photophobia. The IOP in that eye was 15 mmHg while on treatment with dorzolamide-timolol eye drops. No suture-related or other serious complications were observed. The patient expressed satisfaction with the functional and cosmetic results. Conclusions: Modern vitrectomy combined with an artificial iris IOL and scleral fixation with Gore-Tex sutures in eyes lacking an iris and lens can provide long-term anatomic and functional restoration. Intraoperative IOP fluctuations and extra corneal damage can be avoided by lens preparation with the sutures using a small incision ab-externo approach.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":221844164,"openaccessinfo":{"externalids":{"MAG":"3067152557","ACL":null,"DOI":"10.12659\/AJCR.924706","PubMedCentral":"7521177","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The type design is a relatively new activityin Brazil. Its practice has increased since the late 1980's, as a result of the spread of digital technologies. In parallel to the phenomenon of typographic creation, graphic design developeda trend characterized by the incorporation of forms and styles inspired by objects and popular practices, graphic demonstrations prior to the emergence of modern design schools; this trend has been called \"vernacular design\". This article examines the production of Brazilian typedesign, inspired on vernacular elements with the aim of revealing their motivations, the design strategies involved, and the new meanings that these sources may acquire in everyday practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":193238968,"openaccessinfo":{"externalids":{"MAG":"2103387578","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Overexpression of the Saccharomyces cerevisiae ABC transporter Pdr5p confers resistance to a range of structurally unrelated xenobiotics. This property allows Pdr5p to be used as a target for novel multidrug resistance reversal reagents or chemosensitizers. Herein, we report the effects of gallic acid derivatives with substitutions either on the ester moiety or in the benzene ring on the activity of Pdr5p. Compounds with a longer side chain (8-16 carbons) resulted in greater inhibition of Pdr5p ATPase. Derivatives with side chains of 8-12 carbons that retained hydroxyl groups on the benzene ring extensively inhibited Pdr5p ATPase activity. These compounds almost completely inhibited the efflux of the Pdr5p fluorescent substrate Rhodamine 6G and at 25 muM chemosensitized the Pdr5p-overexpressing strain AD124567 to fluconazole (0.4 mg mL(-1)). Gallic acid derivatives may be a new class of Pdr5p inhibitors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42574388,"openaccessinfo":{"externalids":{"MAG":"2078700180","ACL":null,"DOI":"10.1111\/j.1567-1364.2010.00603.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/10\/3\/244\/18020210\/10-3-244.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Autoimmune diseases are characterized by recurrent attacks and remissions, but as a rule they progress and eventually cause a severe disability and death. The present chapter contains general characteristics of autoimmune disease pathogenesis, ways to cause immune tolerance by hematopoietic cell transplantation (HCT), clinical aspects of the treatment for established autoimmune diseases with a special attention to multiple scle - rosis (MS) and systemic sclerosis (SSc). A profound analysis of authors' point of view and of the available literature has been performed. The promising results allows to consider HCT as a relevant treatment option for a certain autoimmune diseases.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":251287609,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This case report describes a combined neurosurgical and endovascular approach for the treatment of a conus medullaris arteriovenous malformation resulting in considerable improvement in the patient's neurological condition (modified Rankin Scale score 2).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212753112,"openaccessinfo":{"externalids":{"MAG":"3009469679","ACL":null,"DOI":"10.1136\/neurintsurg-2019-015268.rep","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:This article explores the relationship between labor precarity, masculinity, and striving among generations of Sudanese male migrant workers in Beirut. Based on fieldwork conducted between 2019 and 2020 with intergenerational, multiethnic Sudanese migrant communities in Beirut and with male migrant returnees in Khartoum, I argue that Sudanese male migrant workers navigate the structures that condition them as precarious labor in Lebanon by forming networks of care and interdependency. How are they gendered through these relations of livelihood and co-survival? I explore how Sudanese male migrants conduct themselves through ideals of masculine propriety and labor discipline in their striving for an ethically and materially sustainable life achieved through marriage and eventual return. Yet in the current context of revolution and accumulating economic crises in Lebanon as well as in Sudan, these goals are foreclosed for young migrants who are caught in a spiral of unemployment and debt. In conversation with migrants who struggle to balance their aspirations of living with the present challenges of surviving, I explore how crisis restructures their relations of codependency, attachments to home, and aspirations for the good life at the end of migration.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":225402564,"openaccessinfo":{"externalids":{"MAG":"3046468623","ACL":null,"DOI":"10.24847\/77I2020.260","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The current study examined monolingual English-speaking toddlers' (N=50) ability to learn word\u2013referent links from native speakers of Dutch versus English, and second, whether children generalized or sequestered their extensions when terms were tested by a subsequent speaker of English. Overall, children performed better in the English than in the Dutch condition; however, children with high native vocabularies successfully selected the target object for terms trained in fluent Dutch. Furthermore, children with higher vocabularies did not indicate their comprehension of Dutch terms when subsequently tested by an English speaker whereas children with low vocabulary scores responded at chance levels to both the original Dutch speaker and the second English speaker. These findings demonstrate that monolingual toddlers with proficiency in their native language are capable of learning words outside of their conventional system and may be sensitive to the boundaries that exist between language systems.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":36853530,"openaccessinfo":{"externalids":{"MAG":"2039075265","ACL":null,"DOI":"10.1017\/S0305000911000067","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Exposure to pesticides has been associated with low lung function. We conducted a systematic review and meta-analysis to summarise evidence currently available on the effect of occupational pesticide exposure on spirometry Methods : Through electronic searches of MEDLINE, Embase and Web of Science we identified 28 papers, reporting on non-specific pesticide exposure, organophosphates or paraquat. Of these, we meta-analysed 14 studies with results available for FVC and FEV 1 , 13 for FEV1\/FVC, 10 for FEF 25-75 and fewer for other measures. As spirometry outcomes were reported in different ways, we performed meta-analyses on standardised mean differences between exposed and non-exposed subjects Results : Pesticide exposure had a negative effect on all spirometry measures, but there was extreme heterogeneity across studies. A reason for heterogeneity was differences in the definition of exposure, with lower effect estimates from studies on subjects exposed to lower pesticide levels, or using cruder definitions of exposure with higher measurement error, as one might expect. The type of pesticides evaluated also explained some heterogeneity, with stronger and more consistent effects for organophosphates, in particularly on FEV1, compared with paraquat or non-specific pesticide exposure Summary : Overall there is evidence of a negative effect of occupational pesticide exposure on lung function, with stronger effects for organophosphates. It is difficult to draw firm conclusions on the magnitude of these effects due to the large heterogeneity of findings between studies, which was partly explained by differences in exposure level and type, as well as accuracy in the definition of the exposure.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":56546333,"openaccessinfo":{"externalids":{"MAG":"1497054611","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We conducted 2 studies to examine if status has varying effects on prosocial behavior for those at different levels of the power hierarchy. In Study 1 (N = 78), adults employed full-time in the USA responded to an online survey and the results showed that self-perceived power\n and status interacted to predict prosocial behavior. That is, lacking status led high-power, but not low-power, individuals to engage less in prosocial behavior. In Study 2 (N = 142), we orthogonally manipulated status and power and measured prosocial behavior. Once again, lacking status\n led to less helping behavior among high-power, but not low-power, participants. These findings show how power and status interact to influence interpersonal helping behavior. Implications for future research on social hierarchy and prosocial behavior are discussed.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":150286986,"openaccessinfo":{"externalids":{"MAG":"2890742873","ACL":null,"DOI":"10.2224\/SBP.6150","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The metalloproteinase tumor necrosis factor-\u03b1-converting enzyme (TACE) is involved in the regulation of several key physiological and pathological processes. Therefore, potent and selective synthetic inhibitors are highly sought for the study of the physiological roles of TACE as well as for therapeutic purposes. Because of the high structural similarities between the active site of TACE and those of other related zinc endopeptidases such as disintegrin (ADAMs) and matrix metalloproteinases (MMPs), the design of such tailor-made inhibitors is not trivial. To obtain new insights into this problem, we have used a selective MMP inhibitor as a probe to examine the structural and kinetic effects occurring at the active site of TACE upon inhibition. Specifically, we used the selective MMP mechanism-based inhibitor SB-3CT to characterize the fine structural and electronic differences between the catalytic zinc ions within the active sites of TACE and MMP-2. We show that SB-3CT directly binds the metal ion of TACE as observed before with MMP-2. However, in contrast to MMP-2, the binding mode of SB-3CT to the catalytic zinc ion of TACE is different in the length of the Zn-S(SB-3CT) bond distance and the total effective charge of the catalytic zinc ion. In addition, SB-3CT inhibits TACE in a non-competitive fashion by inducing significant conformational changes in the structure. For MMP-2, SB-3CT behaved as a competitive inhibitor and no significant conformational changes were observed. An examination of the second shell amino acids surrounding the catalytic zinc ion of these enzymes indicated that the active site of TACE is more polar than that of MMP-2 and of other MMPs. On the basis of these results, we propose that although there is a seemingly high structural similarity between TACE and MMP-2, these enzymes are significantly diverse in the electronic and chemical properties within their active sites.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":43299887,"openaccessinfo":{"externalids":{"MAG":"2025061181","ACL":null,"DOI":"10.1074\/JBC.M401310200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"THE MAINTENANCE of cardiac output by means of rhythmic sternal compression during cardiac arrest has found widespread use since its description by Kouwenhoven and associates in 1960. Successful resuscitations of persons with ventricular asystole or ventricular fibrillation have been reported by those utilizing this method of closed-chest massage. The case described in this report illustrates the effectiveness of this method over an extended period (35 min.). It also demonstrates that cerebral perfusion of a sufficient magnitude may be maintained to keep a patient in a responsive state during ventricular fibrillation. Report of a Case A 63-year-old white man was admitted to University Hospitals on Jan. 17, 1961, for the 15th time. The patient was well known to the hospital staff because of multiple Stakes-Adams attacks dating back to 1955, which had required frequent hospitalizations. In 1957 the patient underwent repair of a hiatus hernia and a vagotomy without a significant","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":34631270,"openaccessinfo":{"externalids":{"MAG":"1968346098","ACL":null,"DOI":"10.1001\/JAMA.1962.03050310086018C","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Enantioselective allylation of carbonyl compounds and aldol reaction are powerful and essential tools for synthesizing optically active homoallylic alcohols and \u03b2-hydroxy carbonyl compounds, respectively. We have found that BINAP\u00b7AgOTf complex is an excellent catalyst for asymmetric allylation of aldehydes with allyltributyltin as well as the asymmetric aldol synthesis of tributyltin enolates with aldehydes, and can furnish the corresponding nonracemic products with high diastereo- and enantioselectivities. These reactions are useful with respect to reactivity and selectivity. Later, we developed an alternative BINAP\u00b7AgOTf-catalyzed asymmetric aldol reaction of an alkenyl trichloroacetate employing a catalytic amount of trialkyltin methoxide. Asymmetric Sakurai-Hosomi allylation of aldehydes with allylic trimethoxysilanes and Mukaiyama-type aldol reaction of trimethoxysilyl enolates have been also achieved using BINAP\u00b7AgF as a chiral catalyst in methanol or using a mixture of BINAP\u00b7AgOTf and KF\u00b718-crown-6 as bifunctional chiral cata-lysts in THF. BINAP\u00b7Ag (I) complexes are also known to catalyze enantioselective nitroso aldol reaction between trialkyltin enolates and nitrosobenzene.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":96955348,"openaccessinfo":{"externalids":{"MAG":"2950550158","ACL":null,"DOI":"10.1002\/CHIN.200607274","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. The \"Coefficient d9Utilisation\" or Plastic Efficiency Coefficient (P.E.C.) has been calculated for each day during development. It has a trough which is deepest between the eighth and ninth days; development is therefore most expensive at this point. The correlation between this and the point of greatest intensity of protein combustion is exact. 2. The \"Rendement Energetique brut\" or Apparent Energetic Efficiency has been calculated for each day during development. It rises, changing more rapidly towards the end than at the beginning; thus it resembles the metabolic rate rather than the growth rate. The \"Rendement Energetique reel\" or Real Energetic Efficiency cannot at present be calculated for the basal metabolism of the embryo is unknown and it is not certain whether the usual conceptions of basal metabolism can be applied to a rapidly growing and changing organism.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":88913894,"openaccessinfo":{"externalids":{"MAG":"2520341428","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fumigant toxicity of crushed fresh bulbs of Allium sativum L. and A. cepa L. to the Callosobruchus maculatus (Fabricius), a major pest of stored cowpea (Vigna unguiculata (L.) Walp.) seeds was assessed under laboratory conditions in Akure, Nigeria. In the tests, 20 g of infested cowpea seeds were suspended in a piece of muslin cloth, over an amount of crushed bulb in a container with a tightly fitted lid. Adult emergence was completely prevented from freshly laid eggs of C. maculatus on cowpea seeds that was fumigated with 6.0 g or more of crushed bulbs of A. sativum. Such fumigated seeds were not holed at all. Other amounts of A. sativum tested (1.0, 2.0, 3.0, 4.0 and 5.0 g) significantly reduced C. maculatus adult emergence from fumigated eggs and seed holing in comparison with the control. Crushed A. sativum was ineffective in preventing adult emergence from fumigated C. maculatus larvae in seeds. The fumigant effect of crushed A. cepa did not kill all C. maculatus eggs. An amount of 7.0 g significantly reduced C. maculatus adult emergence from fumigated eggs and seed holing in comparison with the control. There is good prospect in using crushed bulbs of A. sativum as fumigant in C. maculatus control in stored cowpea seeds.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":58908640,"openaccessinfo":{"externalids":{"MAG":"2097292852","ACL":null,"DOI":"10.4067\/S0718-58392010000300019","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study examined the food security status and the socio-economic effects of climate change on rural farming households in Delta State, Nigeria. The main objective of the study was to determine the food security status of the rural farming households in the state while the specific objective was to determine the socio-economic effects of climate change on rural farming households in the state. Multistage sampling procedure was used in the random selection of local government, communities and rural households for the research study. The data for the study were obtained with the aids of structured questionnaire survey randomly administered to rural farming households in the state. Food security index was used to determine the level of food insecurity (food security status) among the rural households in communities that have been affected by flood and or other climate hazardswhile descriptive statistics was used to summarize the socio-economic effects and their food security status of the rural farming households in the state. Most respondents (65.10%) were married with low annual income of N54,702 ($353) which is less than the poverty line of less than $1 (one dollar) a day. Most rural farming households witnessed loss of investment on farm lands, lives and income respectively in the state. The study also reveals that rural farming households suffered ill health, such as malaria, water borne diseases and skin infections that were on the increase in the state. The study also revealed that majority of respondents was moderately food insecure. The study also recommends that Government planning agencies and policy makers should put into consideration these food insecurity situations in their planning and policy implementation to prevent future chronic food insecurity situation in the state.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":30520302,"openaccessinfo":{"externalids":{"MAG":"1495091484","ACL":null,"DOI":"10.22004\/ag.econ.198115","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We describe a digital holography imaging system that uses synthetic-aperture techniques for improved spatial resolution. The synthetic aperture is formed by illuminating an object from multiple angles, while a hologram multiplexing scheme is used to collect all of the data within a single camera exposure. We show how the multiplexing can be implemented efficiently with an image-plane hologram recording geometry, present results from a laboratory experiment, and discuss practical trade-offs of the approach.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":122944453,"openaccessinfo":{"externalids":{"MAG":"2098667189","ACL":null,"DOI":"10.1364\/AO.54.000559","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":". Based on Roscoe Pound's opinion, the notion of criminal responsibility is a person's obligation to pay retribution that will be received by the perpetrator from someone who has been harmed (the victim). Criminal liability is a person's responsibility for the crimes he commits. The purpose of criminal liability is to determine whether a person who has committed a crime can be held accountable or not. This article will discuss criminal liability for police negligence for the act of shooting tear gas at the Kanjuruhan stadium, where the negligence of the police was due to a lack of caution and carelessness in acting using force in police actions. Namely not being careful and acting without considering the risks in using chemical weapons in the form of tear gas. The use of tear gas should be guided by the principles stipulated in the Police Chief Regulation No. 1 of 2009 concerning the Use of Force in Police Actions. However, in practice the police were negligent and ignored the risks of using tear gas at the Kanjuruhan stadium. The form of the mistake is acting without considering the dangers and threats, and not predicting the possible consequences that will occur. Because his negligence in using tear gas at the Kanjuruhan Stadium had a detrimental impact on other people and on the Indonesian National Police, namely causing deaths and injuries. Due to the Kanjuruhan incident, many of the victims' families have asked for justice for the police's actions in the tear gas shooting at the Kanjuruhan stadium, so that the police actions in the tear gas shooting are considered to be the triggers for the deaths and injuries that need to be held criminally accountable.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264937456,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"LTE in the unlicensed band (LTE-U) is a promising solution to overcome the scarcity of the wireless spectrum. However, to reap the benefits of LTE-U, it is essential to maintain its effective coexistence with WiFi systems. Such a coexistence, hence, constitutes a major challenge for LTE-U deployment. In this letter, the problem of unlicensed spectrum sharing among WiFi and LTE-U systems is studied. In particular, a fair time-sharing model based on the ruin theory is proposed to share redundant spectral resources from the unlicensed band with LTE-U without jeopardizing the performance of the WiFi system. Fairness among both WiFi and LTE-U is maintained by applying the concept of the probability of ruin. In particular, the probability of ruin is used to perform efficient duty-cycle allocation in LTE-U, so as to provide fairness to the WiFi system and to maintain certain the WiFi performance. Simulation results show that the proposed ruin-based algorithm provides better fairness to the WiFi system as compared to equal duty-cycle sharing among WiFi and LTE-U.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":54567775,"openaccessinfo":{"externalids":{"MAG":"2950828314","ACL":null,"DOI":"10.1109\/LCOMM.2018.2890254","PubMedCentral":null,"ArXiv":"1812.04177"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A new SSWI algorithm is described that is based on near real-time data fusion with portions of operational ice charts derived from RADARSAT, OLS or AVHRR data. The aim of this is to enable parts of the ice chart where there is no cloud-free imagery or SAR data to be completed using an SSM\/I algorithm that is tuned to the region and time associated with the ice chart. The algorithm is a linear combination of partial concentrations from the NASA Team and Bootstrap algorithms together with lower variance principal components of SSM\/I data. The algorithm is designed for near real time use in production of operational ice charts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":202597914,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the absence of any definite individuals among its protagonists, Blake Butler's Scorch Atlas (featherproof press, 2009) stages the transformations of substances, both in its contents and its forms, partly through a refined elaboration of the visual aspect of the seemingly blotted or maculated pages, meant to illustrate degradation. Decaying matter and bodies are told in an unheard-of language, constantly deviating from common uses and enhancing the play on sounds and rhythms. This paper aims at showing how the materiality of language in Scorch Atlas may paradoxically both reflect the desire to let the body express itself in words and in the book at large, and convey a secret aspiration towards immateriality as an attempt to escape the passing of time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":161065471,"openaccessinfo":{"externalids":{"MAG":"1610532075","ACL":null,"DOI":"10.3917\/RFEA.132.0048","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An interpolation method based on the criterion to maximize the smoothness is proposed. In contrast to the conventional approach, where the interpolated signal is made smooth by low-pass filtering, in the proposed method, the smoothness is obtained by minimizing a global energy function. With the minimum energy formulation for interpolation, a recursive method is used to derive the solution and named the recursive minimum energy algorithm. Because the smoothness is improved by increasing the calculation iteration but not by increasing the tap length, the controllability of this system is increased. Experiments show that the smoothness and the frequency performance obtained by the proposed algorithm are better than those of the conventional method. Also, the corresponding architecture design for the image interpolation is presented and shown to be suitable for VLSI implementation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":73642394,"openaccessinfo":{"externalids":{"MAG":"2105832327","ACL":null,"DOI":"10.1109\/30.663746","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In recent years, patent protection has extended into new areas, giving rise to serious concern about the lack of clear guidelines for patentability. We analyze the effect of introducing a patent opposition process that would allow patent validity to be challenged directly after a patent is granted. In many cases, such a system would avoid costly litigation at a later date. In other cases, the opposition process would increase the cost of conflict resolution, but would also reward holders of valid patents and limit the rewards to invalid patents. Our analysis suggests significant positive welfare gains from the introduction of a patent opposition process.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":219395041,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.351900","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types. S1P lyase is the enzyme that irreversibly cleaves S1P and thereby constitutes the ultimate step in sphingolipid catabolism. It has been reported previously that embryonic fibroblasts from S1P lyase-deficient mice (Sgpl1\u2212\/\u2212-MEFs) are resistant to chemotherapy-induced apoptosis through upregulation of B cell lymphoma 2 (Bcl-2) and Bcl-2-like 1 (Bcl-xL). Here, we demonstrate that the transporter proteins Abcc1\/MRP1, Abcb1\/MDR1, Abca1, and spinster-2 are upregulated in Sgpl1\u2212\/\u2212-MEFs. Furthermore, the cells efficiently sequestered the substrates of Abcc1 and Abcb1, fluo-4 and doxorubicin, in subcellular compartments. In line with this, Abcb1 was localized mainly at intracellular vesicular structures. After 16 h of incubation, wild-type MEFs had small apoptotic nuclei containing doxorubicin, whereas the nuclei of Sgpl1\u2212\/\u2212-MEFs appeared unchanged and free of doxorubicin. A combined treatment with the inhibitors of Abcb1 and Abcc1, zosuquidar and MK571, respectively, reversed the compartmentalization of doxorubicin and rendered the cells sensitive to doxorubicin-induced apoptosis. It is concluded that upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P lyase-deficient MEFs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207008223,"openaccessinfo":{"externalids":{"MAG":"2014275763","ACL":null,"DOI":"10.1194\/jlr.M052761","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The interaction of the junction potentials in response to ortho- and antidromic hypogastric nerve stimulation in mouse vas deferens was studied, using an extracellular recording method. Ortho-dromic repetitive hypogastric nerve stimulation (10 Hz, 5 min) simultaneously depressed the amplitude of the junction potentials in response to both ortho- and anti-dromic hypogastric nerve stimulation (post-te-tanic depression). No time-lag in recovery from the post-tetanic depression was observed between the junction potentials recorded from two separate electrodes, indicating that the proximodistal axonal flow of available transmitter was not involved in the recovery process. Double shocks, with intervals from 10 msec to 1 sec, were applied to the hypogastric nerve. The junction potentials in response to ortho- and ortho-dromic or anti- and anti-dromic double shock were markedly facilitated. On the contrary, the junction potentials in response to ortho- and anti-dromic double shocks were not facilited. The findings indicate that facilitation of the junction potentials is produced by the impulses propagated in the same direction along the terminal axon and also that the origin of the facilitation may be at a pre-junctional site.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32671249,"openaccessinfo":{"externalids":{"MAG":"2945364725","ACL":null,"DOI":"10.1254\/JJP.25.55","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The possibility of exciting convective motions with a toroidal symmetry in a disordered liquid-crystal cell with an open surface, which is locally heated by a Gaussian laser beam, is demonstrated experimentally. A perturbation of the free surface of the liquid crystal and a convective hydrodynamic motion are determined by temperature gradients. It is shown that a radial distribution of the director of a nematic liquid crystal appears in the convection region. Under certain experimental conditions, soliton-type hydrodynamic orientation waves are observed at the free surface of a nematic liquid crystal. It is found experimentally that the velocity of these waves is determined solely by the liquid-crystal parameters and is independent of the incident laser-radiation power.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250772878,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1070\/QE2004v034n03ABEH002625","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"India reported highest incidence of Mucormycosis in the past and during the second wave of COVID-19. Google Trends is a potential tool for infoveillance of infectious disease like Mucormycosis. Relative Search Volume (RSV) for term Mucormycosis (+ Black fungus), diabetes, steroid, oxygen, D-dimer (+ferritin) had been extracted from Google Trends for three months (March to May 2021) and state-wise prevalence for Mucormycosis released by Ministry of Health and Family Welfare was used for the analysis. India reported highest RSV for Mucormycosis among the top five countries with COVID-19 cases. RSV peak for oxygen preceded the Mucormycosis spike. Correlation between state-wise prevalence of Mucormycosis and their corresponding RSV was not significant. While a positive correlation was observed between Mucormycosis, diabetes and steroid, it was not statistically significant. Infoveillance using Google trends can serve as a proxy marker for the public health needs and priorities much before actual field surveys.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":240596031,"openaccessinfo":{"externalids":{"MAG":"3200853708","ACL":null,"DOI":"10.47203\/IJCH.2021.v33i02.028","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Last week at the International Astronomical Union 24th General Assembly, astronomers announced nine newly discovered planets orbiting other stars. The roster of extrasolar planets, now nearing 50, suggests that stars are fecund breeding grounds for worlds but that young planets must battle hordes of rivals for a handful of stable orbits.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44882806,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Passage of the Diaspora Law of Latvia required policymakers to go through an arduous process of discussing the limitations of diaspora, weighing the potential risks and benefits of various possible approaches, and ultimately agreeing on a definition to be included in the law. The end result was a very broad interpretation of who can be recognized as part of the Latvian diaspora. In this paper, to understand the political process of arriving at a definition, the theoretical perspectives of the 'narrow' and 'broad' definitions of diaspora are discussed, the motivations driving national governments to engage with their diasporas are analysed, and the discourse used during the drafting process is reviewed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":238477816,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2478\/bjlp-2021-0003","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.sciendo.com\/pdf\/10.2478\/bjlp-2021-0003","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This study aims at ascertaining how corporate social responsibility (CSR) relates with financial performance of quoted deposit money banks in Nigeria from 2010-2016. Specifically, this study aims to ascertain the extent of relationship that exists between donation and return on assets; determine the extent of relationship that exists between donation and return on equity and to evaluate the extent of relationship between donations and market-to-book value of quoted deposit money banks in Nigeria. This study employed ex-post facto research design. The sample size of this study consists of the fifteen quoted deposit money banks in Nigeria. Pearson Coefficient Correlation, Panel Least Square (PLS) regression analysis and Granger Causality test were employed via E-View 9.0. The study found a significant positive relationship between return on asset, return on equity, market-to-book value and donations at 5% level of significance. The implication of the findings is that CSR implementation maximizes future returns for deposit money banks in Nigeria. It was recommended among others that since CSR has a positive and significant relationship with financial position, deposit money banks should engage in CSR practices as this will guarantee a safer environment for smooth operations and maximisation of shareholders wealth.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":230641926,"openaccessinfo":{"externalids":{"MAG":"3112776129","ACL":null,"DOI":"10.2139\/ssrn.3704461","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"URBANCOVA, H., URBANEC, J.: Internal factors infl uencing the knowledge continuity. Acta univ. agric. et silvic. Mendel. Brun., 2012, LX, No. 4, pp. 387\u2013396 The aim of the systematic ensuring of knowledge continuity is the continuity of an organisation's development, the quality of managerial positions and the continuity of decision-making. By ensuring knowledge continuity, organisations may gain a performance-enhancing factor. The objective of the article is to identify the level of impact of decisive internal factors determining knowledge continuity ensuring and contributing to the effi ciency of the organisations. Knowledge continuity ensuring as an internal force, however, can together with the right employees, help adapt more quickly to external conditions that organisations can hardly control. Monitoring and ensuring knowledge continuity can contribute to a higher quality of processes in general, in particular processes exploiting knowledge, and thus help improve the level of management. The fi rst part of the article presents theoretical views on the aspects of knowledge continuity ensuring in organisations while the second part analyses the fi ndings of the surveys carried out among managers in organisations in the Czech Republic. Based on the summary of the outcomes obtained it is possible to say that internal factors infl uence knowledge continuity ensuring in organisations, however, the level of impact of individual factors is determined by their size. The fi ndings regarding the impact of each of the factors show that the most signifi cant barriers to knowledge continuity ensuring are those associated with the human factor. knowledge continuity management, knowledge, factors, process, organisations, survey","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55342278,"openaccessinfo":{"externalids":{"MAG":"2085253741","ACL":null,"DOI":"10.11118\/ACTAUN201260040387","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"of Incorporations and Their Authorized Capital Stock\"; Medium, and Small Business Corporations\"; \"An Industrial Classification of Incorporation\"; \"Fields of Corporate Enterprise.\"","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153660979,"openaccessinfo":{"externalids":{"MAG":"1732408771","ACL":null,"DOI":"10.1017\/S0022050700063142","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of outreach activities with the title of \" The Administrators Empowerment An Nur Dadung Mosque in the administrator's management is to help the mosque administrators as the responsible to manage all activities and routines\u00a0which connected for ummah on the religious, education and economics\". The second purpose, is to improve the scientific religion administrators An Nur Dadung mosque. To achieve the purpose of outreach has been implemented by a lecturer team faculty of economic and management, University of Darussalam Gontor, the outreach activities is conducted in the form of management training, discussion, and administrators supervision activities. From the outreach activities carried out by An Nur Dadung mosque, Mantingan, Ponorogo it can be concluded that an increase in the participation of society on activities conducted by An Nur mosque administrators. The existence of thought between a members of An Nur mosque administrators in fostering the community of this mosque. There's no mosque administrators thought an old fashioned (jumud) and blamed another communities in terms of believed (madzhab).The next holding the investigation in Sunday morning between mosque each monthly with a doorprize from muhsinin and breakfast together.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":158519405,"openaccessinfo":{"externalids":{"MAG":"2791089698","ACL":null,"DOI":"10.21111\/iej.v3i1.1386","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/ejournal.unida.gontor.ac.id\/index.php\/JEI\/article\/download\/1386\/pdf_32","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Based on the regularities of the first stage of lifecycle for the social system of industrial education it is predicted the status of initiation for education and perception system around the turn of the anthropocene eon. It is emphasized that the process of the new age education system set- up takes place in self-organizing mode. For this purpose, the following is assessed: 1) the state of the \"spirit of the era\", that carries an personalized (information, network, knowledge, digital) society, as an example of a new type of life order for the global community; 2) worldview imperatives of eco-humanistic filling of the educational community of the planet; 3) ideological guidelines for sustainable development; 4) conceptual prerequisites for the formation of a new education type that do not correspond in any way to the transformation of the violent paradigm of education and upbringing of young people of the technocratic age; 5) the state of fundamental science as a reason that, on the basis of mastering a new classification of social labor, should generate a modernization of education content in the 21st century; 6) the content of the involved segment of senseogenesis, which gives rise to a new division of information work in order to qualitatively service new operation forces, leading to the benefits of the development of spiritual production over material. It is prognosed that the new social division of labor will form a qualitatively new nomenclature of workers in domain of national and international education. \nThe problems of the current state of the theory of education and pedagogy are revealed, those does not have time to produce perspectives of national and international educational policies relevant to the needs of the planet's social organism. The attention of educators focused on the inadequacy of the existing pedagogical and organizational facilities to impact on the formation of creative personality, since they only improve the conservation of the industrial education system. The planetary personality is justified as the ideal of an educated person of the 21st century and the ultimate goal of education and upbringing in the World Knowledge Society. The principle of personalization \/ individualization is defined as the main parameter of managing the generation of the future education system. Emphasis is placed on the benefits of an open system of education that enhances the degree of individual freedom in a globalized world. Educators and education managers are encouraged to turn to the principles of evolution, which more strongly contribute to the spread of human activity in the school. The attractiveness of the idea of self-education for the modern young generation in the virtual space of the information age is emphasized.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":216419346,"openaccessinfo":{"externalids":{"MAG":"3010707650","ACL":null,"DOI":"10.37836\/2309-7744-2020-1-2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Several aspects of the biology of the three players in a vector-borne disease that affect their evolutionary interactions are outlined. A model of the origin of a human\u2013human cycle of vector-borne diseases is presented emphasizing the narrowing of the niche experienced by the pathogen and vector. Variation in the expected rates of evolution of the three players is discussed with the rapid rate of pathogen evolution providing them with advantages. Population sizes and fluctuations also affect the three players in very different ways. The time since the origin of a vector-borne disease likely determines how stable the interactions are and thus how easily the disease might be eliminated. Stability and variation are also linked. Human technological advances are rapidly upsetting the previously relatively slow coevolutionary adjustment of the three players. Finally, it is pointed out that development of quantitative coevolutionary models specifically addressing details of vector-borne diseases is needed to identify parameters most likely to break transmission cycles and thus control or eliminate diseases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209377513,"openaccessinfo":{"externalids":{"MAG":"2990476556","ACL":null,"DOI":"10.3389\/fgene.2019.01266","PubMedCentral":"6929172","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2019.01266\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Motivated by many ambitious modern applications \u2013 genomics and proteomics are examples, we consider a two-class linear classification in high-dimensional, low-sample size setting (a.k.a. p n). We consider the case where among a large number of features (dimensions), only a small fraction of them is useful. The useful features are unknown to us, and each of them contributes weakly to the classification decision \u2013 we call this setting the rare\/weak model (RW Model [2]). The success of linear classification hinges on how to select a small subset of useful features. We select features by thresholding feature z-scores. The threshold is set by the recent innovation of higher criticism (HC) [1, 2]: Let i \u03c0 denote the p-value associated to the i-th z-score and () i \u03c0 denote the i-th order statistic of the collection of p-values, the HC threshold (HCT) is the order statistic of the z-score corresponding to index i which maximizes the ratio () () () () () \/ \/ 1 i i i i n p p p \u2212 \u2212. HCT has many interesting features as follows. Asymptotic optimality in threshold selection. We formalize an asymptotic framework for studying the RW model, considering a sequence of problems with increasingly many features and relatively fewer observations. We show that along this sequence, the limiting performance of HCT is essentially just as good as the limiting performance of ideal thresholding \u2013 the optimal thresholding one would use when underlying parameters are known. Optimal partition of the phase diagram. Our asymptotic analysis frames the notion of two-dimensional phase space, a two-dimensional diagram with coordinates quantifying \" rare \" and \" weak \" in the RW model. The phase space can be partitioned into two regions \u2013 one where ideal threshold classification is successful, and one where the features are so rare and so weak that it must fail. Surprisingly, the regions where HCT succeeds and fails partition the phase diagram in the exact same way. In comparison, many popular threshold choices (e.g. that by controlling the False Discover Rate) don't have the same partition of regions in the phase diagram, and are therefore suboptimal. Outperforms popular threshold choice methods. We show that HCT behaves very differently from other analytical principles popular today (e.g. False Discovery Rate control or Sure Screening). We also show that HCT is dramatically faster and more stable than cross validation thresholding. Comparison to recent classification methods \u2026","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263357232,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Broiler chicks were treated by oral gavage on the day of hatch with a continuous-flow competitive exclusion culture (PREEMPT). At 4 h, 1 day, or 2 days posttreatment, chicks were challenged by oral gavage with 10(2) or 10(4) Salmonella CFU to determine the effects of challenge time on Salmonella cecal colonization. Cecal propionic acid concentrations in two trials increased (P < or = 0.001) within 1 day posttreatment in chicks given PREEMPT, and the increases were indicative of the establishment of the PREEMPT bacteria. Salmonella cecal populations decreased (P < or = 0.001) on average 6 log10 units in these two trials in chicks challenged 4 h posttreatment with 10(4) Salmonella CFU. In a third trial propionic acid did not increase significantly until 2 days after treatment, and there was no decrease in Salmonella colonization when chicks were challenged at 4 h after treatment. However, there were decreases in that same trial when chicks were challenged at 1 and 2 days after treatment. The early establishment of PREEMPT followed by challenges with 10(2) and 10(4) Salmonella CFU resulted in 3% and 3%, respectively, of the ceca testing Salmonella-culture-positive, compared to 28% and 95%, respectively, culture-positive ceca in untreated chicks. The results from this study indicated that in most instances young broiler chicks can be protected against cecal colonization when challenged with 10(2) and 10(4) Salmonella CFU as early as 4 h posttreatment on the day of hatch with the PREEMPT bacteria.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5656773,"openaccessinfo":{"externalids":{"MAG":"2343208818","ACL":null,"DOI":"10.4315\/0362-028X-61.6.673","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Jet engines may experience severe vibration due to the sudden imbalance caused by blade failure. The current research investigates employment of piezoelectric actuators to suppress this using active vibration control. This requires identification of the source of the vibrations via an expert system, determination of the required phase angles and amplitudes for the correction forces, and application of the desired control signals to the piezoelectric actuators. Correction forces may exceed the physical limitations of the actuators; hence results of ''constrained force'' quadratic programming, least squares and multi-point correction algorithms will be compared. It is demonstrated that simply scaling down the least squares predicted correction forces to satisfy the actuator saturation constraints does not necessarily yield optimal reductions in vibration. In this paper test results are shown for sudden imbalance, and the computational time requirements and balancing effectiveness for the various approaches are compared. 7 1997 Academic Press Limited","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":16928605,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim. In this study, the aim is to evaluate the knowledge level about hepatitis B (HBV) of the students receiving education in vocational school of health services, who are a risky group for HBV infection, and to examine their awareness and immune status. Material and methods. The data of this research was collected by a questionnaire prepared by the researcher. The sample in the study consisted of 537 (81.4%) students. The data were evaluated using the SPSS 16.0 package program. Frequency, percentage, Pearson chi-square and Fisher's exact test was used in the analyzation of the data. Outcomes and conclusions. It was determined that the students who participated in the research did not show sufficient sensitivity to get vaccinated against HBV and to know their serological status. It was also identified that they had a lack of knowledge and\/or did not have clear information about the modes of transmission of HBV, its treatment, and that HBV may cause cirrhosis. The results of this research will guide students in the trainings to be given in order to raise their awareness on this subject and to ensure that they are immunized before they start working and have practical training in the field of healthcare.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":237392375,"openaccessinfo":{"externalids":{"MAG":"3194372910","ACL":null,"DOI":"10.37897\/rjid.2021.2.6","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.37897\/rjid.2021.2.6","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this paper, our experience with training courses for quality circle moderators is reported. Basic principles of the peer review method in general and the specific model of the topic-oriented quality circle approach in the ambulatory care in Sudbaden is described. Peer review in quality circle groups demands specific participants' skills. Thus, training courses for quality circle leaders have been set up to prepare moderators for their task. Attention is given to the goals and contents of training courses for physicians. Key elements are the supervisory role of the moderator and specific tasks in handling the group dicussions. Evaluation questionnaires after the courses showed that the participants (n = 41) judged the programme very positively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27791296,"openaccessinfo":{"externalids":{"MAG":"2473555313","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effect of 6 inhalational anaesthetics on speed of swimming (produced by ciliary movement) has been studied in Tetrahymena pyriformis. There was no evidence of stimulation at low dose levels and higher levels caused rapid, reversible, dose-dependent reduction in swimming velocity. The concentrations of anaesthetics which depressed motility by 50% were of the same order as those required for anaesthesia in mammals, except in the case of cyclopropane, for which the required level was 4 times higher than the anaesthetic level. Correlation with lipid solubility was not as close as is the case for narcotic concentration. Oxygen consumption was reduced with increasing amounts of halothane in parallel with the reduction in swimming velocity. Halothane produced deciliation of Tetrahymena at about 10 times the anaesthetic dose for man; regrowth of cilia took place within 4 h of withdrawal of the drug. There were no changes in the ultrastructure of the cilia, basal bodies and associated microtubular systems at levels of halothane sufficient to stop cilial beat. At higher concentrations deciliation occurred immediately distal to the axosome and there was variable swelling of the mitochondria.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":42121628,"openaccessinfo":{"externalids":{"MAG":"2396835511","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bayesian Networks (BNs) are useful tools giving a natural and compact representation of joint probability distributions. In many applications one needs to learn a Bayesian Network (BN) from data. In this context, it is important to understand the number of samples needed in order to guarantee a successful learning. Previous work have studied BNs sample complexity, yet it mainly focused on the requirement that the learned distribution will be close to the original distribution which generated the data. In this work, we study a different aspect of the learning, namely the number of samples needed in order to learn the correct structure of the network. We give both asymptotic results, valid in the large sample limit, and experimental results, demonstrating the learning behavior for feasible sample sizes. We show that structure learning is a more difficult task, compared to approximating the correct distribution, in the sense that it requires a much larger number of samples, regardless of the computational power available for the learner.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1170457,"openaccessinfo":{"externalids":{"MAG":"2950557487","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1206.6862"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nitric oxide (NO) is a small, ubiquitous bioactive molecule, postulated as a broad spectrum anti-stress compound. The NADPH oxidase inhibitor apocynin induces the accumulation of endogenous NO in leaves of maize seedlings through a nitric oxide synthase (NOS)-like activity, and confers an augmented tolerance to UV-B-induced oxidative damage. Here we propose a mechanism for the apocynin-induced NO increase in plants. NOS catalyzes the oxidation of arginine to citrulline and NO. It is suggested that apocynin inhibit arginase, the enzyme that hydrolyzes L-arginine to urea and L-ornithine, increasing the arginine availability for arginine-dependent NO synthesis. Superoxide (O2-) is a strong NO scavenger due to its high reactivity with NO to give peroxynitrite (ONOO-). Superoxide is mainly produced by plant NADPH oxidase (pNOX). Inhibition of pNOX by apocynin at relatively high NO concentration, could reduces the formation of O2- and ONOO-, increasing the availability of a huge amount of NO. We consider apocynin as a very attractive compound for studying NO-regulated processes in plants since it can replace the use of NO donors and overcome the subsequent technical problems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23025580,"openaccessinfo":{"externalids":{"MAG":"2003275407","ACL":null,"DOI":"10.4161\/psb.4.9.9429","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/psb.4.9.9429?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Video game addiction is one of the mental health problems due to the uncontrolled activities in accessing video game platforms. This study aimed to identify the tendencies of video game addiction among Senior High School students based on the aspects of Regulatory Focus Theory and interpersonal competence. It implemented a quantitative descriptive model with a 2\u00d72 factorial design. A total of 1046 students participated in the survey. The findings revealed the increasing video game addiction cases among the students during the COVID-19 pandemic. The students with a high promotion focus and a high interpersonal competence as well as those with a low prevention focus and a low interpersonal competence tended to experience video game addiction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":234846480,"openaccessinfo":{"externalids":{"MAG":"3153920190","ACL":null,"DOI":"10.1097\/ADT.0000000000000262","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Critical Incident Stress (CIS) is any event that evokes a critically high level of stress and makes usual coping skills ineffective. Programs to manage this stress have been developed. Due to the unique stressors encountered in the pediatric emergency department, this article proposes a CIS management program for these healthcare providers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37933008,"openaccessinfo":{"externalids":{"MAG":"2354830415","ACL":null,"DOI":"10.4037\/CCN1992.12.1.78","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a simple analytical expression of the extraction efficiency for planar dielectric microcavity light-emitting diodes (MCLEDs) based on two distributed Bragg reflectors (DBRs). The calculations take into account the optical properties of the resonator (reflectivities and index contrast of the DBRs, cavity length, refractive index of the outside medium), as well as the spectral properties of the active material. The analytical results are compared to exact numerical calculations based on the plane wave expansion method and show good agreement. Simple design rules for optimizing the extraction efficiency of MCLEDs are proposed and discussed for display and fiber coupling applications. The limits of MCLEDs are finally investigated and compared to those of conventional light-emitting diodes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":123600986,"openaccessinfo":{"externalids":{"MAG":"2102211147","ACL":null,"DOI":"10.1109\/2944.999173","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"SUMMARY: A defined medium HP6\/B used by Christie & Porteous (1962) for the cultivation of a single strain (Wills) of Actinomyces israelii contained sixteen growth factors. By using the quantitative inoculation technique of Christie & Porteous (1960) and a semi-quantitative method for assessing growth it has now been found that the Wills strain will grow in the presence of only five of the sixteen growth factors. These growth factors are: biotin, inositol, nicotinic acid, pyridoxal, riboflavin.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":85393301,"openaccessinfo":{"externalids":{"MAG":"2069979298","ACL":null,"DOI":"10.1099\/00221287-28-3-455","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1099\/00221287-28-3-455","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background\/Aims: Although previous studies showed a high prevalence of abnormal ankle-brachial index (ABI) in patients with ischemic stroke, few data exist regarding ABI in Asian patients with ischemic stroke. The purpose of the present study was to determine the prevalence and factors associated with abnormal ABI (\u22640.9) in a cohort of ischemic stroke patients. Methods: In this prospective multicenter study, 1,293 patients diagnosed with acute ischemic stroke or transient ischemic attack underwent ABI measurement to evaluate an association between abnormal ABI and vascular risk factors and clinical characteristics. Differences in ABI by stroke subtypes were also assessed. Results: Abnormal ABI of \u22640.9 was found in 13.0%. Patients with abnormal ABI were more likely to be older and had higher initial stroke severity. The prevalence of abnormal ABI was 18.4% in large artery atherosclerosis, 7% in small artery disease, and 19.2% in cardioembolism (p < 0.001). Multiple logistic regression analysis showed that age, hyperlipidemia, diabetes, and large artery atherosclerosis subtype were independent factors associated with abnormal ABI. Conclusions: These data suggest that the prevalence of abnormal ABI in Korean patients with ischemic stroke was lower than that in Caucasian patients, which might be associated with ethnic differences in underlying stroke subtypes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24759601,"openaccessinfo":{"externalids":{"MAG":"1988706957","ACL":null,"DOI":"10.1159\/000342892","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction The role of Mycophenolate mofetil (MMF) as an immunomodulatory drug in managing inflammatory bowel disease is yet to be fully defined. We reviewed our experience of the efficacy, safety and tolerability of MMF in treating patients with refractory inflammatory bowel disease. Methods A retrospective analysis was performed of the case records of all patients treated with MMF for inflammatory bowel disease at our institution between 2003 and 2011. Remission was assessed by reviewing clinical, endoscopic and laboratory indices. Results We identified 36 patients, 23 male (64%) with a median age 46\u2005yrs (range 19\u201375). Disease was classified as Crohn's disease in 19, ulcerative colitis 16, indeterminate colitis.1 33 patients (92%) had previously received azathioprine; 32 discontinued this due to side-effects. Five patients had undergone surgery for small bowel Crohn's disease. The starting dose of MMF was between 500\u2005mg and 2\u2005g daily, titrated to a dose of 2\u2005g daily as tolerated. 26 patients (72%) were concurrently taking oral corticosteroids, and 18 (50%) were taking an oral 5-aminosalicylate. At 8\u2005weeks, 29 patients (81%) had either achieved acute remission or maintained previous remission. Drug side-effects were experienced by eight patients (22%)\u2014these symptoms were managed successfully by dose reduction in six patients (75%), with discontinuation in two patients. There were no serious haematological or other adverse drug effects. After 6\u2005months of treatment, 33 patients continued to take MMF of which 19 patients (58%) had achieved sustained steroid-free remission. Median length of MMF treatment observed was 21.5\u2005months (IQR 9.7\u201331.6). At the end of the observation period, 29 patients (81%) remained on MMF. 13 patients (36% of the original treatment group; UC 7, Crohn's 5) remained in steroid-free remission with median time of remission 21.4\u2005months (IQR 11.0\u201330.0). A further 13 patients achieved sustained remission with the addition of corticosteroids and\/or anti-TNF therapy. Five patients (14% overall) were refractory to all medical therapy and underwent surgery: colectomy for UC 3, right hemicolectomy for Crohn's.2 Conclusion From our experience, MMF may represent a promising alternative treatment for inducing and maintaining remission in patients intolerant of or unable to receive thiopurines. It appears well tolerated with a good safety profile in thiopurine intolerant subjects. Competing interests None declared.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":72555502,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/gutjnl-2012-302514c.115","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/gut.bmj.com\/content\/gutjnl\/61\/Suppl_2\/A232.2.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Cancer is increasingly recognized as a complication of HIV infection in both resource-rich and resource-limited areas. The traditional AIDS-defining cancers, including Kaposi sarcoma, cervical cancer, and non-Hodgkin lymphoma, have become common comorbidities afflicting HIV-positive individuals and lack adequate prevention and management options. Additionally, several non-AIDS-defining cancers have increased in incidence in resource-limited regions, including Hodgkin lymphoma, hepatocellular carcinoma, and lung cancer. This review outlines the epidemiology of HIV-associated malignancies in resource-poor and resource-rich areas, including the impact of highly active antiretroviral therapy on the incidence of these cancers. The pathogenesis of HIV-associated cancers is considered in relation to potential strategies for their prevention and treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31575020,"openaccessinfo":{"externalids":{"MAG":"2107310768","ACL":null,"DOI":"10.1146\/annurev-med-050409-103711","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The mechanisms of coating failure of the fuel particles for the high-temperature gas-cooled reactors during coating and compaction processes of the fuel fabrication were studied to determine a way to reduce the defective particle fraction of the as-manufactured fuels. Through the observation of the defective particles, it was found that the coating failure during the coating process was mainly caused by the strong mechanical shocks to the particles given by violent particle fluidization in the coater and by unloading and loading of the particles. The coating failure during the compaction process was probably related to the direct contact with neighboring particles in the fuel compacts. The coating process was improved by optimizing the mode of the particle fluidization and by developing the process without unloading and loading of the particles at intermediate coating process. The compaction process was improved by optimizing the combination of the pressing temperature and the pressing speed of the overcoated particles. Through these modifications of the fabrication process, the quality of the as-manufactured fuel compacts was improved outstandingly.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":94656585,"openaccessinfo":{"externalids":{"MAG":"1979064922","ACL":null,"DOI":"10.3327\/JNST.34.325","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One of the major components of any evolutionary system is the evaluation function. Evaluation functions are used to assign a quality measure for individuals in a population. Whereas evolutionary computation techniques assume the existence of an (efficient) evaluation function for feasible individuals, there is no uniform methodology for handling (i.e., evaluating) unfeasible ones. The simplest approach, incorporated by evolution strategies and a version of evolutionary programming (for numerical optimization problems), is to reject unfeasible solutions. But several other methods for handling unfeasible individuals have emerged recently. This paper reviews such methods (using a domain of nonlinear programming problems) and discusses their merits and drawbacks.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":63947104,"openaccessinfo":{"externalids":{"MAG":"124424457","ACL":null,"DOI":"10.7551\/mitpress\/2887.003.0018","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.cs.adelaide.edu.au\/~zbyszek\/Papers\/p17.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Nonlinear time-domain numerical modeling requires the development of absorbing boundary conditions to effectively absorb the nonlinear electromagnetic waves. In this paper, based on Berenger's PML (1994), the nonlinear perfectly matched layer (nPML) absorbing condition is developed and implemented in the recently proposed TLM-based FDTD method. Numerical results show the effectiveness of the nPML. The proposed nPML scheme can also be implemented in other FDTD schemes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41143146,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/mwsym.1997.596586","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Staff groups for nurses are seen as useful for stress reduction and team building, with a widely-held belief that they should be made available and used by staff. However, while usually requested by service managers, staff have varying views regarding their need and varying levels of comfort with participation. This article considers the challenges that are faced in setting up staff support groups for two different groups of nurses. The first group, for paediatric nurses working on an adolescent medical in-patient unit, is now a settled and established entity. The second group, for a community paediatric nursing team, continues to evolve in response to changing needs. Ways to adapt the group model to increase attendance rates and ensure the groups are helpful are presented. This article is intended as a resource for professionals who are already running groups or are considering establishing one.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22103438,"openaccessinfo":{"externalids":{"MAG":"1983772134","ACL":null,"DOI":"10.1177\/1367493504041855","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we present a distributed average-consensus algorithm with non-linear updates. In particular, we use a weighted combination of the sine of the state differences among the nodes as a consensus update instead of the conventional linear update that just includes a weighted combination of the state differences. We show the non-linear average-consensus converges to the initial average under appropriate conditions on the weights. By simulations, we show that the convergence rate of our algorithm outperforms the conventional linear case.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":15152551,"openaccessinfo":{"externalids":{"MAG":"2115855280","ACL":null,"DOI":"10.1109\/ACSSC.2009.5469905","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Antiparasite responses are associated with the recruitment of monocytes that differentiate to macrophages and dendritic cells at the site of infection. Although classically activated monocytic cells are assumed to be the major source of TNF and NO during Trypanosoma brucei brucei infection, their cellular origin remains unclear. In this study, we show that bone marrow-derived monocytes accumulate and differentiate to TNF\/inducible NO synthase-producing dendritic cells (TIP-DCs) in the spleen, liver, and lymph nodes of T. brucei brucei-infected mice. Although TIP-DCs have been shown to play a beneficial role in the elimination of several intracellular pathogens, we report that TIP-DCs, as a major source of TNF and NO in inflamed organs, could contribute actively to tissue damage during the chronic stage of T. brucei brucei infection. In addition, the absence of IL-10 leads to enhanced differentiation of monocytes to TIP-DCs, resulting in exacerbated pathogenicity and early death of the host. Finally, we demonstrate that sustained production of IL-10 following IL-10 gene delivery treatment with an adeno-associated viral vector to chronically infected mice limits the differentiation of monocytes to TIP-DCs and protects the host from tissue damage.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8045141,"openaccessinfo":{"externalids":{"MAG":"1936332344","ACL":null,"DOI":"10.4049\/jimmunol.182.2.1107","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.aai.org\/jimmunol\/article-pdf\/182\/2\/1107\/1273688\/zim00209001107.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In the modern health care environment, the usage of IoT technologies brings convenience of physicians and patients, since they are applied to various medical areas. The body sensor network (BSN) technology is one of the core technologies of IoT developments in healthcare system, where a patient can be monitored using a collection of tiny-powered and lightweight wireless sensor nodes. However, the development of this new technology in healthcare applications without considering security makes patient privacy vulnerable. In this paper, at first, we highlight the major security requirements in BSN-based modern healthcare system. Subsequently, we propose a secure IoT-based healthcare system using BSN, called BSN-Care, which can efficiently accomplish those requirements. The body sensor network (BSN) technology is one of the most imperative technologies used in IoT-based modern healthcare system. It is basically a collection of low-power and lightweight wireless sensor nodes that are used to monitor the human body functions and surrounding environment. Since BSN nodes are used to collect sensitive (life-critical) information and may operate in hostile environments, accordingly, they require strict security mechanisms to prevent malicious interaction with the system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209064169,"openaccessinfo":{"externalids":{"MAG":"2987056143","ACL":null,"DOI":"10.15662\/IJAREEIE.2019.0805010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Modification of signals in the time-frequency domain are used in many applications. However, the modification is often restricted to be purely multiplicative. In this paper, it is shown that, in the continuous case, a quite general class of operators can be represented by a twisted convolution in the short-time Fourier transform domain. The discrete case of Gabor transforms turns out to be more intricate. A similar representation will however be derived by means of a special form for the operator's spreading function (twisted spline type function). The connection between STFT- and Gabor-multipliers, their spreading function and the twisted convolution representation will be investigated. A precise characterization of the best approximation and its existence is given for both cases. Finally, the concept of Gabor multipliers is generalized to better approximate ''overspread'' operators.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73625984,"openaccessinfo":{"externalids":{"MAG":"2663820482","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A DFT study of protonation thermodynamics in H(2)-evolving biomimetic catalysts related to [FeFe]-hydrogenases active site is presented here. Taking as a reference system the electrocatalytic dihydrogen evolution mechanism recently proposed for the synthetic assembly [Fe(2)(CO)(4)(kappa(2)-Ph(2)PCH(2)CH(2)PPh(2))(mu-S(CH(2))(3)S)] (a, which is able to release H(2) after having undergone monoelectron reduction steps and three sequential protonation reactions), we show how the reduction of model complexes to oxidation states lower than those observed in [FeFe]-hydrogenases cofactor leads to a protonation regiochemistry that has no counterpart in the enzymatic mechanism of H(2) production. In particular, double protonation of the metal centers turned out to be disfavored in a by up to 12.5 kcal mol(-1) with respect to alternative protonation paths; as for the regiochemistry of triple protonation, the formation of eta(2)-H(2) adducts is disfavored by at least approximately 25 kcal mol(-1). Structural analysis of the theoretical models also revealed that over-reduction of synthetic complexes, though necessary for observing H(2) evolution from the currently available biomimetic electrocatalysts, can generally impair their structural integrity. Possible approaches for the modulation of protonation regiochemistry are then proposed; in particular, it turned out that a targeted use of sigma-donating ligands showing low basicity can favor double protonation of iron centers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22198752,"openaccessinfo":{"externalids":{"MAG":"2147061386","ACL":null,"DOI":"10.1039\/b926040d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study aimed to analyze the buying interest factors of Samyang products by using attitude as an intervention factor based on maqasid sharia. Data were collected using questionnaires. The type of this study was quantitative using a purposive sampling technique. The applied data analyses were validity, reliability, classic assumption, and statistical tests using path analysis. The results indicated that product knowledge and price had a positive and significant effect on attitude. Meanwhile, halal certification and halal awareness do not affect attitude. Furthermore, the price and attitude had a positive and significant effect on buying interest. Meanwhile, product knowledge, halal certification, and halal awareness do not affect buying interest. Attitude can mediate product knowledge and prices towards the buying interest of Samyang products. Besides, the results of the hypothesis using the F-test showed that the product knowledge, halal certification, halal awareness, price, and attitude simultaneously had a positive effect on buying interest.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":247592351,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2), is a causative agent of current global pandemic of Coronavirus disease-19 (COVID-19). Due to propagated outbreak and global vaccination drive an immense immunological selection pressure has been exerted on SARS CoV-2 leading to evolution of new variants. This study was performed to compare the mutational and clinical profile of liver disease patients infected with different variants of SARS CoV-2. Methodology This was a single-centre, retrospective, cohort study in which clinicogenomic analysis of liver disease (LD) patients infected with SARS CoV-2 was performed. Complete demographic and clinical details were retrieved from Hospital Information System (HIS). QC-threshold passed FASTA files containing sequences from COVID-19 patients (n=174) were compared with a reference genome of SARS-CoV-2 isolate named Wuhan-Hu-1 (NCBI Reference Sequence: NC_045512.2) for mutational analysis. Results Out of 232 finally analysed patients 137 (59.1%) were LD-CoV (+) and 95 (40.9%) were LD-CoV(-). LD patients with comorbidities were affected more with COVID-19 (p=0.002). On comparing the outcome in the terms of mortality, LD-CoV (+) had 2.29 times (OR 2.29, CI 95%, 1.25-4.29) higher of odds of succumbing to COVID-19 (p=0.006). Multivariate regression analysis revealed, abdominal distention (p=0.05), severe COVID-19 pneumonia (p=0.046) and the change in serum bilirubin levels (p=0.005) as well as Alkaline phosphatase (ALP) levels (p=0.003) to have an association with adverse outcome in LD patients with COVID-19. In Delta (22%) and Omicron (48%) groups, Spike gene harboured maximum mutations. On comparing the mutations between LD-CoV(+\/D) and LD-CoV(+\/O) a total of nine genes had more mutations in LD-CoV(+\/O) whereas three genes had more mutations in LD-CoV(+\/D). Conclusion We concluded that LD patients are more susceptible to COVID-19 as compared to a healthy adult with associated adverse clinical outcomes in terms of mortality and morbidity. Therefore this special group should be given priority while devising and introducing new vaccination and vaccination policies. The infection with different variants did not result in different outcome in our group of patients.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":257258974,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2023.02.26.530067","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2023\/02\/27\/2023.02.26.530067.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"There are two methods for applying path delay tests to a sequential circuit. We show that all path delay faults that can affect the rated-clock operation of the circuit are testable by the variable-clock method. Also, all path delay faults that are untestable by the variable-clock method are, in fact, untestable by the rated-clock method. However, some faults tested by the variable-clock method may be incapable of affecting the rated-clock operation. Our study is based on a finite-state machine model in which fault-free transitions are shown by green arcs. Faulty transitions are shown by red arcs. A test traverses successive arcs until a faulty output occurs. A variable-clock test can exercise more flexibility in selecting from green and red arcs. It can cover all functional paths, but may find only a proper subset of untestable paths. Our analysis assumes a delay fault, consisting of either a singly-testable path or multiply-testable paths, and hence corresponds to non-robust detection.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":11104455,"openaccessinfo":{"externalids":{"MAG":"2113045124","ACL":null,"DOI":"10.1109\/ICVD.1998.646651","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A usage-based approach to parenthetical LOOK Italian Abstract The present article examines the broad function of attention-getting embodied by parenthetical LOOK in Chinese, Dutch, English and Italian. It analyzes a sample of the marker's occurrences in corpora of spontaneous conversations and of interviews and discussions in terms of a systematic typology of parameters of interactional behavior and adopts a range of statistical methods to uncover patterns of (dis)similarity. The results include, inter alia, a cross-linguistic preference for clause-initial and turn-initial\/medial position, a strong association across languages with assertive and expressive speech acts and an attraction to the onset of quotations. Variation in and exceptions to these tendencies are observed too. The findings are explained with reference to phenomena such as persistence and entrenchment and contribute to a better understanding not only of attention-getting in different languages but also of intersubjectivity, constructed dialogue and illocutional concurrences.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249011538,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper delineates a computational framework to ascertain optimum thermal generation schedule using newfangled grey wolves optimization (GWO) technique corresponding to environmentally sustainable, economic operation. This scheduling problem is devised as a biobjective optimization and linear interpolated price penalty model is developed based on simple analytical geometry equations which blends two non-commensurable objectives perfectly. In order to obtain high-quality solutions within lesser executing time, the algorithm parameters are nicely replaced with system parameters that carry out global and local search process in the feasible region collaboratively. Further, an appropriate constraint handling mechanism is suitably incorporated in the algorithm that intern produces a stable convergence characteristic. The effectiveness of the proposed approach is illustrated on six unit thermal systems with due consideration of transmission line loss and valve point loading effect. The desired GWO technique reports a new feasible solution for quadratic and non-convex thermal operating model which is compared with the solution that has evolved earlier and the comparison shows that the GWO technique has outstripped other algorithms effectively.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":220378445,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two novel approaches of recombinant PCR technology were employed to graft the complementarity determining regions from a murine monoclonal antibody (mAb) onto human antibody frameworks. One approach relied on the availability of cloned human variable region templates, whereas the other strategy was dependent only on human variable region protein sequence data. The transient expression of recombinant humanized antibody was driven by the adenovirus major late promoter and was detected 48 hrs post-transfection into non-lymphoid mammalian cells. The application of these new approaches enables the expression of a recombinant humanized antibody just 6 weeks after initiating the cDNA cloning of the murine mAb.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13456575,"openaccessinfo":{"externalids":{"MAG":"2036319555","ACL":null,"DOI":"10.1093\/NAR\/19.9.2471","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: Apneas are classified in three categories, as obstructive, central, and mixed types. Mixed apneas are calculated together with the obstructive events in diagnosing obstructive sleep apnea syndrome (SAS). The clinical significance of mixed apneas needs to be specified. Methods: Patients with obstructive SAS having an index of mixed apneas \u22655\/hour were evaluated. A new approach was developed to score the mixed apneas, and calculated them together with either obstructive or central type of events, depending on their obstructive and central components. The relationship between the development of complex SAS and the indices of abnormal respiratory events per standard and revised scoring was evaluated. Results: Ten of 56 patients (17.9%) developed complex SAS at titration polysomnography. The mean index of mixed apneas per standard scoring was significantly higher in patients who did not develop complex SAS (P = 0.006). The use of newly developed method in scoring mixed apneas resulted that three patients (5.4%) fulfilled the diagnostic criteria for the central SAS at first-night polysomnography (P < 0.001), and all of them had developed complex SAS at titration night requiring other modes of positive airway pressure therapy than the continuous mode (P = 0.004). Curve estimation models showed that the change from mixed apneas to central apneas was highly significant in patients developing complex SAS (r2 = 0.501; P = 0.022). Conclusions: Our study showed that the summation of mixed apneas with the obstructive events conventionally underestimates the central components and the diagnosis of central SAS, which are fundamental in the risk stratification of complex SAS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235243588,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/WNP.0000000000000869","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The development of profound autonomic dysfunction and of neuroendocrine activation characterizes and possibly contributes to the progression of heart disease to congestive heart failure. Sympathetic activation is a generalized process and the proposed mechanisms for neurohumoral activation include decreased input from excitatory afferences and increased input from excitatory chemoceptors and metabaroceptor. These phenomena vary to a great extent in different subjects: in the more impaired patients, renal and cardiac overflow of catecholamines can increase three- and ten-fold, respectively, accounting for about 60% of the increase of noradrenaline in congestive heart failure. Efficient methods to quantify sympathetic cardiovascular influences and neuroendocrine indices have been developed and it has been recognized that sympathoneural activation independently predicts the survival of patients. The pathophysiological role and the clinical relevance of neuroadrenergic abnormalities also constitute the grounds for the understanding of the therapeutic benefit obtained with interventions aimed at mitigating the harmful consequences of adrenergic hyperactivity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6823317,"openaccessinfo":{"externalids":{"MAG":"2246501197","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study supervisor localization for timed discrete-event systems under partial observation in the Brandin-Wonham framework. First, we employ timed relative observability to synthesize a partial-observation monolithic supervisor; the control actions of this supervisor include not only disabling action of prohibitible events (as that of controllable events in the untimed case) but also \"clock-preempting\" action of forcible events. Accordingly we decompose the supervisor into a set of partial-observation local controllers one for each prohibitible event, as well as a set of partial-observation local preemptors one for each forcible event. We prove that these local controllers and preemptors collectively achieve the same controlled behavior as the partial-observation monolithic supervisor does. In the resulting local controllers\/preemptors, only observable events can cause state change. The results are illustrated by a timed workcell example.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14410075,"openaccessinfo":{"externalids":{"MAG":"2296843208","ACL":null,"DOI":"10.1109\/CDC.2016.7798994","PubMedCentral":null,"ArXiv":"1603.02023"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although dual disorders (DD), addiction, and other mental disorders (MDs) are common in patients using mental health and addiction treatment services, they are not routinely screened for and diagnosed by most health experts. The aim of this article was to present the most relevant findings from the Madrid study on DD in a clinical sample from the Community of Madrid mental health and substance misuse service care networks. The sample consisted of 837 outpatients from Madrid: 208 patients from mental health services and 629 from substance misuse services. We used the Mini International Neuropsychiatric Interview (MINI) to evaluate Axis I MDs and the Personality Disorder Questionnaire (PDQ4 +) to evaluate personality disorders (PDs). DD cases were those in which there was a current diagnosis of an addictive disorder (excluding nicotine addiction) and another MD including PDs. The DD prevalence rate was 61.8%. There were differences in the prevalence figures for the 2 types of service: 36.1% in mental health services and 70.3% in substance misuse services. Among dual diagnosis patients there were fewer male individuals, a higher rate of unemployment, and higher figures for alcohol and cannabis dependence than among addicts only (n = 194). There were differences in several sociodemographic characteristics, and dual diagnosis patients were associated with diagnoses of bipolar disorders, agoraphobia, generalized anxiety disorder, and posttraumatic stress disorder. They also presented a greater suicide risk and had more PDs than patients with MD diagnoses only, excluding substance use disorders (n = 126). There is a high prevalence of DDs among those seeking treatment, more so in substance misuse services than in mental health services, and they have different characteristics that suggest greater severity. These findings could be of help in planning care service policies for these patients.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":80351671,"openaccessinfo":{"externalids":{"MAG":"2739616385","ACL":null,"DOI":"10.1097\/ADT.0000000000000119","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The past months have been characterised by what can be called a \"backlash against globalisation\". This development became most visible in the outcome of the Brexit referendum in the UK and the election of Donald Trump as the future president of the US. In both cases, the preceding campaigns massively referred to antiglobalisation sentiments in the population, as do others in Germany, France, the Netherlands, etc. The discussion about the origins of these phenomena has centred on the question whether those voting in favour of isolationism have, indeed, been left behind by globalisation, or whether the benefits of international market integration have simply not been communicated well to them. The latter perspective implies that voting against the integration of one's own country into the world economy is an ill-informed, possibly irrational choice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59455679,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Want to use an Adobe tool to design animated web graphics that work on iPhone and iPad? You've come to the right book. Adobe Edge Animate Preview 7: The Missing Manual shows you how to build HTML5 graphics using simple visual tools, just as with familiar programs like Photoshop and Flash. No programming experience? No problem. Adobe Edge Animate writes the underlying code for you. With this eBook, you'll be designing great-looking web elements in no time. Bestselling author Chris Grover has more than 25 years experience in graphic design and electronic media. He excels in making complex technology fun and easy to learn. In Adobe Edge Animate Preview 7: The Missing Manual, he continues the winning formula of Flash CS5.5: The Missing Manual and Google SketchUp: The Missing Manual. Throughout the book, illustrations make it clear what you should be seeing onscreen as you work through step-by-step instructions. You can download example files to work with, or create your own animations right from the start. With the purchase of this book, you'll be able to download updates to the electronic versions, which will be updated to keep up with changes to Adobe Edge.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":60256728,"openaccessinfo":{"externalids":{"MAG":"626087874","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Selection of a dominant follicle from a wave of follicles is manifested by diameter deviation between future dominant (F1) and largest subordinate (F2) follicles. On day \u20131 or 0 (day 0 = beginning of deviation), growth rate of F1 continues and growth rate of F2 decreases. Deviation occurs during the decline in the wave-stimulating FSH surge when F1 reaches means of 8.5, 10.5, and 22.5 mm in heifers, women, and mares, respectively. Diameter of F1 at the FSH peak vs at deviation is proportionally similar among these monovular species. In conventional deviation, F1 usually emerges first. In F1,F2-switched deviation, F2 is usually first to emerge and to reach a diameter characteristic of deviation. On day \u20131 or 0, the larger F2 and the smaller F1 switch so that the formerly larger F2 becomes subordinate and the formerly smaller F1 becomes dominant. In heifers and mares, the profile and prominence of the FSH surge are similar between deviation classes. Surge location relative to deviation differs so that the surge ends earlier in switched deviation. When the larger F2 reaches a diameter characteristic of deviation, FSH concentration is too low for continued growth of F2. The decrease in FSH ceases (heifers) or increases (mares) presumably from a decrease in FSH inhibitors; therefore, F1 continues to grow and becomes dominant. The frequency of switched deviation (e.g., 16 to 37% among species) can be problematic in follicle-selection research. Switching is a natural model for study of the interplay between follicles and FSH.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":51602176,"openaccessinfo":{"externalids":{"MAG":"2811511499","ACL":null,"DOI":"10.1093\/biolre\/ioy151","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/99\/6\/1129\/27192456\/ioy151.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Human norovirus is a leading cause of foodborne disease and can be transmitted through many routes, including environmental exposure to fomites. In this study, both the recovery and inactivation of two human norovirus surrogates, feline calicivirus (FCV) and murine norovirus (MNV), on hard nonporous surfaces (glass) and soft porous surfaces (polyester and cotton) were evaluated by both plaque assay and reverse transcription quantitative PCR method. Two disinfectants, sodium hypochlorite (8.25%) and accelerated hydrogen peroxide (AHP, at 4.25%) were evaluated for disinfection efficacy. Five coupons per surface type were used to evaluate the recovery of FCV and MNV by sonication and stomaching and the disinfection of each surface type by using 5 ml of disinfectant for a contact time of 5 min. FCV at an initial titer of ca. 7 log PFU\/ml was recovered from glass, cotton, and polyester at 6.2, 5.4, and 3.8 log PFU\/ml, respectively, compared with 5.5, 5.2, and 4.1 log PFU\/ml, respectively, for MNV with an initial titer of ca. 6 log PFU\/ml. The use of sodium hypochlorite (5,000 ppm) was able to inactivate both FCV and MNV (3.1 to 5.5 log PFU\/ml) below the limit of detection on all three surface types. AHP (2,656 ppm) inactivated FCV (3.1 to 5.5 log PFU\/ml) below the limit of detection for all three surface types but achieved minimal inactivation of MNV (0.17 to 1.37 log PFU\/ml). Reduction of viral RNA by sodium hypochlorite corresponded to 2.72 to 4.06 log reduction for FCV and 2.07 to 3.04 log reduction for MNV on all three surface types. Reduction of viral RNA by AHP corresponded to 1.89 to 3.4 log reduction for FCV and 0.54 to 0.85 log reduction for MNV. Our results clearly indicate that both virus and surface types significantly influence recovery efficiency and disinfection efficacy. Based on the performance of our proposed testing method, an improvement in virus recovery will be needed to effectively validate virus disinfection of soft porous surfaces.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28494443,"openaccessinfo":{"externalids":{"MAG":"2411191450","ACL":null,"DOI":"10.4315\/0362-028X.JFP-14-515","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": In the present study, the effects of classical oils (kerosene, fuel oil) and their mixtures (25% Kerosene + 75% fuel oil; 50% Kerosene + 50% fuel oil; 75% Kerosene + 25% fuel oil) on the enrichment of Soma Lignite coal by flotation were investigated. The effects of collector amount on combustible recovery, ash reduction and efficiency index, which are among the parameters that are effective in the enrichment of Soma Lignite coal using both pure and mixed classical oils, were analyzed. In the experiments made with pure oils, the best value in terms of combustible part recovery was obtained with fuel oil. Combustible recovery obtained from experiments with mixtures are higher than those with pure oils. It should be noted that especially in experiments with 25% kerosene + 75% fuel oil, higher combustible recovery values were obtained. According to these results, it shown that depending on the oil or emulsion type, the degree of processes taking place at the coal-air-water interface and the presence of unstable functional groups in the oils seem to significantly affect the flotation performance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":249335942,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lung function, studied with spirometry, nitrogen washout technique, and methacholine responsiveness, was prospectively investigated in a seven-year follow-up study of 35 laboratory animal workers (19 women and 16 men) of whom 11 were skin prick test (SPT) positive to laboratory animal allergens; five had asthma and six had rhinitis symptoms. During the follow-up, 82% of the SPT positive subjects had stopped animal work, compared with 29% of the SPT-negative subjects. In baseline spirometry, there was no decrement in the lung volumes or differences between SPT-positive and SPT-negative subjects. At follow-up, no difference was found in vital capacity (VC), forced expiratory volume during one second (FEV1), or residual volume (RV), but the volume of trapped gas (VTG), which is assumed to measure small airways, had increased with a median of 11 mL (P = 0.03). Subjects sensitized to laboratory animals had a minor increase in methacholine responsiveness in FEV1 at follow-up (P = 0.03). The VTG responsiveness was already increased in the first examination (P = 0.035) and remained so at follow-up. Furthermore, the FEV1 responsiveness could predict a subsequent decline in baseline VC and FEV1. In conclusion, our results support the hypothesis that airway responsiveness in immunoglobulin E-mediated allergy might start in small airways and subsequently affect large airways.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35247796,"openaccessinfo":{"externalids":{"MAG":"1987764575","ACL":null,"DOI":"10.1097\/00043764-199802000-00007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this study, we explore a newly available unique data set that links China's international trade transactions to its manufacturing firms' census data and establish a number of interesting stylised facts linking firms' key economic performances to their exporting\u2010importing behaviours. One novelty of our analysis is that we distinguish between ordinary trade and processing trade; the latter involves importing inputs and materials to be assembled and re\u2010exported to the overseas market. Several novel patterns emerge. First, we discover significant heterogeneity within two\u2010way traders \u2013 in terms of size, productivity and factor intensity \u2013 depending on their engagement in processing exports\/imports. Whilst the existing literature typically finds that two\u2010way traders are larger and more productive than one\u2010way traders, we show that pure processing two\u2010way traders are actually the least productive and exhibit the lowest capita\/skill intensity compared to one\u2010way traders. Second, consistent with the market hierarchy hypothesis, larger and more productive firms trade with a larger number of trade partners that are on average 'less popular' as characterised by longer distances and smaller market size. Remarkably, this pattern is highly symmetric between exports and imports, as well as between ordinary and processing trade. Third, firms with greater capital and skill intensities source more complex inputs from countries with higher income per capita, and this pattern holds only for ordinary imports but not for processing imports. While some of our findings confirm existing stylised facts reported for other countries, some patterns we discover are new to the literature and remain to be reconciled with the heterogeneous firm trade theory.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":153907930,"openaccessinfo":{"externalids":{"MAG":"1933324856","ACL":null,"DOI":"10.1111\/twec.12019","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Expression strategies for the synthesis of higher-plant and cyanobacterial RuBP carboxylase genes in Escherichia coli have been developed to facilitate the study of the assembly pathway and properties of the enzyme's large (L) and small (S) subunit proteins. The genes for the L and S subunits of the RuBP carboxylase of wheat and of a cyanobacterium, Synechococcus 6301 have been cloned into bacteriophage and plasmid vectors such that they are transcribed and translated in E. coli. To data no RuBP carboxylase activity has been detected in extracts prepared from E. coli cells synthesizing the wheat L and S subunits, although both gene products were present and soluble. Sucrose gradient analysis of cell extracts from E. coli synthesizing both L and S demonstrated that the soluble wheat L polypeptide was present as a large protein aggregate that contained no S subunits. With the cloned cyanobacterial genes, RuBP carboxylase activity could be recovered in E. coli cell extracts when the L and S gene products were synthesized from genes present on the same, or separate, replicons. Solubility and sedimentation studies of the cyanobacterial L subunits synthesized in the absence of S showed that the L subunit was soluble and present in E. coli as an L $_8$ structure. The E. coli extracts containing only the L subunit exhibited no detectable RuBP carboxylase activity. Infection of the E. coli cells containing L subunits with an M13 phage expressing the cyanobacterial S gene led to the assembly of functional RuBP carboxylase in these cells. This demonstrates the essential role of the S subunit in allowing the formation of an active enzyme.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":83634073,"openaccessinfo":{"externalids":{"MAG":"1983002501","ACL":null,"DOI":"10.1098\/RSTB.1986.0051","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider several topics in the theory of partitions, foc using on questions regarding multipartitions. Results include the formulation of a c ombinatorial explanation of the crank statistic generalized to multipartitions; the conjecture and proof of several multipartition identities; the calculation of the number of k-partitions of n with crank , n-1, or n-2; the construction of a crank-reversing bijection on the partitions of n; the defin itio , and characterization of movable multipartitions, the proof of several partition identitie s for movable multipartitions; the definition of friendly partitions, and a generating function for the numb er of friendly partitions of n.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33921636,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Building upon social exchange theory, this study was designed to examine the impact of job security, job satisfaction, and employee engagement on the commitment level of employees working at Mohmand Jahed group of companies (MJC), a Kabul based logistics supply and services providing company. A self-administered survey instrument was used to collect data from the participants. Employees working at MJC (N=180) were the participants of the study. The study found that job security, job satisfaction, and employee engagement are the positive and significant predictors of employee commitment that explain 62% variation in the criterion variable (employee commitment). Although, results of the present study are in line with the previous research findings, nevertheless, the findings of the study cannot be generalized, since the data were collected from the participants of one of the Kabul based companies (i.e., MJC). A large sample size from different logistics supply and services providing companies can help in the more profound understanding of the phenomenon as well as drawing the real picture of an issue in Afghanistan.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":235194267,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.31841\/kjems.2021.73","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.31841\/kjems.2021.73","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"& Many novice teachers experience a reality shock during the transition from teacher education programs to the first years of teaching, due to the unpredictable and dynamic nature of authentic educational contexts (Veenman, 1984, p. 143). To better understand novice teachers in transition, research on teaching English to speakers of other languages (ESOL) has explored their shifting behaviors and beliefs during the first years of teaching (Farrell, 2009). However, this line of research has rarely examined the transformation of professional identities of novice ESOL teachers in a comprehensive way that allows for a broader understanding of the reality shock from the teachers' own perspectives \u2014how they understand their relationship to the world, how that relationship is constructed across time and space, how they understand possibilities for the future (Norton, 2000) during transition from teacher education programs to real-world teaching contexts. In order to address this gap in the literature, this article reports on a 3-year longitudinal case study of the transformation of the professional identities of four Chinese ESOL teachers during the first years of teaching in K\u201312","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55759304,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"6 vertical levels of the entire 365-day global FGGE Illb analysis for 5 variables are subjected to a time-series analysis and a frequency filter to investigate the structure of the 30- to 50-day mode. This study isolates regions where the amplitude of these low-frequency oscillations are large; the vertical structures across these large amplitude regions are also presented. The seasonal variation of the maximum 30\u201350 day filtered wind in the lower troposphere is highlighted. The major results for the FGGE year show that the 30- to 50-day mode has its largest amplitude in the upper troposphere of polar latitudes and in the summer monsoon region. During the northern winter, active regions are also located over the equatorial belt of the central Pacific ocean. The phase propagation on the pressure surfaces are examined simply from an analysis of a time sequence of low-frequency weather maps. The vertical phase propagation is illustrated by pressure-time plots of the low-frequency data sets at individual locations. This analysis suggests vertical propagation over convective areas and a lack of it over most other regions. A highlight of this study is a phenomenon we have labelled as \"low-frequency storms\". Here we illustrate long-lasting, low-frequency, weather systems that propagate meridionally (1) over the summer monsoon regions from the equator to the Himalayas and (2) over the eastern Pacific ocean from the equator northwards during the northern winter season. An example of such a long-lasting system is traced to 60\u00b0 N; subsequently, it appears to move zonally from the gulf of Alaska across the Canadian Arctic, north Atlantic, and Europe prior to its dissipation over Siberia. The potential for interactions between these low-frequency systems and polar front cyclones is another interesting aspect of this investigation. The low-frequency oscillations and motions are considered important since their amplitude in the troposphere is large (8 ms -1 ) and they are well-defined within their scales of motion (on the order of 4000 km or larger). DOI: 10.1111\/j.1600-0870.1985.tb00432.x","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":120581747,"openaccessinfo":{"externalids":{"MAG":"1974320424","ACL":null,"DOI":"10.3402\/TELLUSA.V37I4.11677","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We demonstrate the successful implementation of genetic algorithm for the retrieval of atomic potentials using elastic differential cross sections (DCSs) between free electrons and atomic ions for electron energies from a few to several tens of electron volts. Since the DCSs over this energy region can be extracted from laser-generated high-energy photoelectron momentum spectra, the results suggest that infrared lasers can be used to image the target structure. Extending to molecular targets, in particular, to transient molecules created by an earlier pump pulse, our results suggest that few-cycle infrared probe lasers can be used for dynamic chemical imaging with temporal resolution of a few femtoseconds.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":14134176,"openaccessinfo":{"externalids":{"MAG":"1975582643","ACL":null,"DOI":"10.1103\/PHYSREVA.79.052508","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SIR,-In a recent editorial (1986;43:649-51) Norseth discussed the complex problem ofchromium carcinogenicity. He presented some of the myriad data resulting from epidemiological investigations, animal carcinogenicity assays, short term tests, and biochemical studies. The emerging concept that some reactive intermediate formed during the intracellular reduction of hexavalent chromium-for example, the pentavalent form-may be the ultimate carcinogen was also presented. Also, we agree that the experimental data may perhaps reflect the involvement of multiple mechanisms in chromium toxicology. We were disappointed, however to read Norseth's conclusion that \"all chromium compounds must be regarded as having a carcinogenic effect.\" Such a statement is not substantiated by the bulk of available publications and, most important, does not take into account that chromium is an essential element. Therefore, we cannot share the view that all the forms of chromium, even those playing an \"essential\" nutritional part, may be regarded as carcinogenic. In addition, we would like to contribute to the invitation that \"further studies on the microkinetics of the various chromium compounds in different cell systems and in the respiratory tract of experimental animals seem to be urgently required.\" In fact, we have been investigating in short term tests a large number ofchromium compounds of different valence, physical state, and solubility. Moreover, we have been exploring chromium metabolism using several tens of biological preparations, including body fluids and cell preparations of various tissues from different animal species, including man, either under normal conditions or under the influence of diseases, drugs, enzyme inducers, metabolic inhibitors, special diets, and treatments. We cannot summarise these data but we would like to complete some of the points raised in the editorial. A fundamental issue is the site at which hexavalent chromium is reduced. Due to the poor ability of trivalent chromium to cross cell membranes, reduction outside target cells provides an important detoxification device. This occurs actively in erythrocytes, which may explain the delimitation of chromium carcinogenicity at administration sites. Saliva and gastric juice are also efficient in reducing chromium (several tens of milligrams a day in man, as assessed on the basis of circadian analyses) (De Flora S, et al, unpublished observations), thus presenting an almost insurmountable barrier to chroBritish Journal of Industrial Medicine 1987;44:355-357","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41944212,"openaccessinfo":{"externalids":{"MAG":"2073150599","ACL":null,"DOI":"10.1136\/oem.44.5.355","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/oem.bmj.com\/content\/oemed\/44\/5\/355.1.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background: Piperine is an alkaloidal compound and is an active constituent of black and long peppers. Piperine is known to inhibit cytochrome P- 450 isoforms. The objective was to determine the effects of dietary piperine on the pharmacokinetics and pharmacodynamics of pioglitazone. \n \nMethods and Results: Set one non diabetic study, there are three groups, as 1,2 and 3 composed each of four Albino rabbits (2-3 kg). In the next set, another similar three groups named group 4 group 5 and group 6 were selected to investigate the influences in diabetic group after receiving alloxan monohydrate (80 mg\/kg, i.v). Group 1 and group 2; group 4 and group 5 received pioglitazone (10 mg\/kg; po) and piperine (20 mg\/kg; po) respectively. Group 3 and group 6, we investigated herb drug interactions for single dose and multiple dose interactions on normal and diabetic rabbits with piperine for single day and for eight days. On the last day of piperine pre-treatment, pioglitazone was given. 1 ml blood samples collected intravenously via marginal ear vein, at the pre set time points and PK & PD parameters were measured. Serum levels of pioglitazone measured using RP-HPLC and glucose levels measured. Significant changes observed under multiple dose pre-treatment of piperine. AUCtot of pioglitazone significantly increased in normal and diabetic rabbits. The biological half-life (t1\/2) was increased whereas clearance was decreased. Maximum percentage glucose reduction was increased significantly in both single and multiple dose pre-treatment of piperine in diabetic rabbits. The observations suggest an interaction due to metabolic inhibition of CYP enzymes. \n \nConclusion: Piperine increases the bioavailability of pioglitazone in normal and diabetic rabbits. Piperine, pioglitazone combination has a beneficial effect in diabetes but it may require special care and should be given under medical supervision with appropriate dose combinations in severe diabetes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53646285,"openaccessinfo":{"externalids":{"MAG":"2333763895","ACL":null,"DOI":"10.4172\/2155-6156.1000356","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4172\/2155-6156.1000356","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Minnie Cunningham (1870\u20131954) was a British music hall star and actress whose career spanned nearly forty years. Today she is primarily remembered through paintings made of her by the prominent British artist Walter Sickert (1860\u20131942) in the early 1890s. Despite her popularity, Cunningham has mostly been overlooked in music hall and theatre histories. Instead, the limited information that is available about her today comes to us primarily through art-history scholarship on Sickert. To fill this gap, this paper offers the first scholarly account of Cunningham by drawing together press notices, published interviews, and other artefacts from her long career. This introduction to Cunningham is framed by a discussion of the unevenness of the cultural transactions taking place between these artists \u2013 between the 'higher' arts practice of modern painting and the perceived 'lower' music hall. I consider how this imbalance played out at the time these artists worked and the impact this has had in the preservation (or lack thereof) of their artistic practices.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":213510462,"openaccessinfo":{"externalids":{"MAG":"3006180058","ACL":null,"DOI":"10.1017\/S030788332000005X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An in-built revision programme and regular opportunities to revisit concepts mean students are not cramming at the last minute. This work features: hundreds of past paper examination questions are included so students have regular exposure to exam level questions from the outset, giving them confidence for the real thing; plenty of worked examples showing the key technique and thousands of questions mean that your students have plenty of practice at each of the key skills; questions are clearly differentiated with the most difficult ones highlighted so students can see where they are achieving and where they need more practice; skills breaks allow students to practise all they have learnt in a new context so that they build up their ability to transfer knowledge, which is vital for the examination; and emphasis on building algebraic skills supports this requirement of the new specifications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":106570256,"openaccessinfo":{"externalids":{"MAG":"656787233","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The statistical hadronization model ThermalFist was applied to 17 hadron yields measured in p+p collisions at \u221a s = 17.3 GeV. Recently published yields of \u03c6, K\u2605(892)0, \u039e, \u039e, and \u039e(\u039e)0 (1530), measured by the NA61\/SHINE Collaboration were accounted for. We consistently used the energydependent widths of Breit-Wigner mass distributions of hadronic resonances, as this attempt was found to provide better agreement with experimental data. Several variants of the model were applied to the data, including the canonical treatment of either (i) all the yields or (ii) those with open strangeness, and the grand canonical approach for the rest. For the full data set only the latter approach gave moderately reasonable agreement with data. This result points to the larger volume of strange particles compared to non-strange ones, weakly supported by femtoscopic analyses at higher collision energies. The unjustified removal of the well established experimental \u03c6 meson yield provided good fit quality for both canonical and strangeness-canonical approaches.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":247274132,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.22323\/1.380.0242","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/pos.sissa.it\/380\/242\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"This article presents a new method of examining the impact of climate change on tourism using the example of ski areas. To date, the consequences of climate change have mostly been investigated at high levels of aggregation in space and time, such as countries and years. Detailed analyses are essential, however, because different regions are affected to varying degrees. Within a complex model incorporating feedback between various system components, such as hydrological and climatic processes as well as demography and economy, possible developments of various sectors are simulated in the Upper Danube watershed in central Europe. Using a multiagent approach, we rise to the challenge to take both socioeconomic and natural aspects into account and enable the simulation of human system reaction and adaptation to climate change. The presented approach is an adequate way to consider the fact that within human\u2013environment systems, environmental changes influence human living conditions and vice versa. We use a multiagent system, in combination with different climate and societal scenarios, to investigate the supply-side operating ability of tourism facilities and the demand-side reactions. Thus, we can calculate the tourism water demand, which is not recorded in official statistics. We present and discuss selected results for ski areas, such as the regionally differentiated development of tourism water consumption and overnight stays' trends. With their high level of individualization, the tourism model simulation results foster the finding of economically reasonable investment strategies. In addition, the tourism model results give rise to future research, such as tourism demand-side examinations concerning the perception of climate change, and resulting behavioral shifts.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":129733600,"openaccessinfo":{"externalids":{"MAG":"2054907582","ACL":null,"DOI":"10.1080\/00045608.2011.561126","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The objective of this study was to qualitatively explore the role of pharmacy technicians in the implementation of an appointment-based model (ABM) medication synchronization program. The purposeful sampling of technicians working within six different locations of a supermarket chain pharmacy in Mississippi and Tennessee was carried out, and the technicians were interviewed between January and April 2018. A semi-structured interview guide was developed based on the Consolidated Framework for Implementation Research (CFIR). Questions gathered information around pharmacy technician demographics and CFIR domains (process, inner setting, outer setting and intervention characteristics). Interviews were audiotaped and transcribed. Two members of the research team performed thematic content analysis. Six full-time, certified pharmacy technicians with 8.3 \u00b1 2.7 years of experience were interviewed. Findings suggest that including hands-on experience with program software is needed during training to successfully implement ABM. A barrier to implementation was the time needed to complete ABM tasks as compared to other tasks. Although some barriers exist regarding implementation, technicians believe that overall, this program has positive benefits for patients. Results from this study signify that ABM implementation can be challenging. Better ABM portal integration with the pharmacy patient profile and appropriate workforce budgeting are key to continued success.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212569061,"openaccessinfo":{"externalids":{"MAG":"3010202970","ACL":null,"DOI":"10.3390\/pharmacy8010028","PubMedCentral":"7151672","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2226-4787\/8\/1\/28\/pdf?version=1583813162","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Obstructive sleep apnea (OSA) is a prevalent sleep disorder known to be associated with\u00a0cardiovascular risk factors and metabolic syndrome (MetS). The studies on OSA burden in MetS patients\u00a0in India is scarce.\nAim: To study prevalence of OSA in MetS and to study factors associated with OSA among MetS.\nSettings and design: Hospital based cross-sectional study was conducted for 2 years (year 2015-2016) at\u00a0a Tertiary Care Teaching Hospital in Pune.\nMaterials and Methods: MetS patients aged 18 years, of either sex were included in this study.\u00a0Polysomnography was performed in all patients and grading of OSA severity was based on the apneahypopnea\u00a0index (AHI).\nStatistical analysis: Data was analyzed in SPSS V:20. To find association of OSA with MetS and its\u00a0components, statistical tests like chi-square, independent student t\u2013test and One-way ANOVA test were\u00a0applied.\nResults: Study prevalence of OSA among MetS patients was 73.3%. Relatively older age group\u00a0(50.6814.15years), male sex (81.0%), obesity (84.4%). Among OSA group, Mild OSA was present\u00a0in 40.91%, moderate grade OSA in 31.8% and severe grade OSA in 27.27%. Severe grade OSA\u00a0was significantly associated with older age (45.67 14.3 years), obesity (35.758.3 Kg\/m2), higher\u00a0serum triglyceride and lower HDL-C levels, larger waist (110.7511.9cm) and neck circumference\u00a0(40.585.2cm).\nConclusions: Central obesity, larger waist circumference, dyslipidemia were striking features of OSA\u00a0patients that were significantly associated with severe grades of OSA. A trend of increased fasting blood\u00a0sugar levels, systolic and diastolic blood pressure levels were noted in severe OSA groups. Thus, OSA is\u00a0associated with higher levels of metabolic dysfunction.\n\nKeywords:\u00a0Cardiovascular risk,\u00a0Dyslipidemia,\u00a0Obstructive sleep apnea,\u00a0Metabolic Syndrome,\u00a0Obesity,\u00a0Body mass index.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233338243,"openaccessinfo":{"externalids":{"MAG":"3129256420","ACL":null,"DOI":"10.18231\/J.IJIRM.2021.002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"By transforming the Takagi equations into a representation using angular coordinates, it is in principle possible to obtain analytical expressions for the coefficients in a series expansion for the primary extinction factor in perfect crystals with a circular diffraction plane. In practice, it has been possible to obtain the first five terms in the expansion. This involves establishing recurrence relations for the families of Bragg and Laue boundary-value Green functions combined with integrations over the entrance and exit surfaces. The calculations, which cover the whole range of values for the scattering angle, theta oh, are performed using the mathematical software systems Mathematica and Maple.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13646980,"openaccessinfo":{"externalids":{"MAG":"2012169808","ACL":null,"DOI":"10.1107\/S010876739701252X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Foreign direct investment (FDI) plays an extraordinary and growing role in global business. For many years, Thailand was among the most open in the developing world to foreign investment. This study aims to examine the determinants of foreign direct investment in Thailand. The study focuses on macroeconomic variables (GDP, exchange rate and labor cost) and mega events (red shirt and yellow shirt protests, world economic crisis and the interaction effect between red shirt and yellow shirt protests and world economic crisis). The data employed in this study is quarterly data from 2000 to 2009. Regression analysis is used as the method of analysis and the econometric program (E-Views) is used to test the model. The empirical results from this study indicate that GDP and exchange rate depreciation have positive influence on FDI inflow to Thailand; while red shirt and yellow shirt protests and world economic crisis have negative influence on the FDI inflow to Thailand, which is consistent with the previous literatures. However, labor cost and the interaction effect between red shirt and yellow shirt protests and world economic crisis do not have impact on the FDI inflow to Thailand.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":155267498,"openaccessinfo":{"externalids":{"MAG":"2279933915","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND OBJECTIVES\nIndividuals with schizophrenia spectrum disorders must manage residual symptoms as they age, and they may experience premature or accelerated aging in comparison with those without their diagnosis. To explore their life course perspectives, we interviewed institutionalized adults aging with schizophrenia spectrum disorders in middle and older age.\n\n\nRESEARCH DESIGN AND METHODS\nWe used an exploratory descriptive design and qualitative methods. Participants answered semi-structured, open-ended questions about perceptions of their mental illness along the life course.\n\n\nRESULTS\nParticipants (N = 30, age 45-83 years) were from an acute care psychiatric facility and a long-term care facility: 16 (53%) men, 14 (47%) women; 6 (20%) Hispanic, 10 (33%) African American, 14 (47%) non-Hispanic White. Participants' life course included traumas from violence, homelessness, and stigma; psychiatric symptoms such as worry and sadness; and age-related physiological symptoms including illness, loss of strength, falls, and incontinence, with falls and incontinence reported only in long-term care. Aging within institutionalization included lack of privacy and autonomy, and isolation (less socialization). Participants provided insights for potential improvements.\n\n\nDISCUSSION AND IMPLICATIONS\nBecause these aging adults are experts on their own care, researchers should continue to seek their input to inform their health care.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":265032897,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/geront\/gnad149","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE--Evaluation of detection of hypertension in adults in the county of Nord-Tr\u00f8ndelag, Norway. DESIGN--Cross sectional survey with clinical follow up examinations. SETTING--Health survey by screening teams from the national health screening service, and examinations by all 106 general practitioners in the county. SUBJECTS--During 1984-6, 74,977 persons (88.1% of those aged 20 years and over) participated in the health survey. MAIN OUTCOME MEASURES--Hypertension (when assessed by standardised recording and by questionnaires on drug treatment for hypertension) according to the blood pressure thresholds used in the Norwegian treatment programme. Subjects positive on screening were grouped after clinical examination into treatment groups. RESULTS--In all, 2399 subjects were positive for hypertension. Before screening 6210 (8.3%) patients reported taking antihypertensive drugs and another 3849 (5.1%) had their blood pressure monitored regularly. All who screened positive were referred to their general practitioner and evaluated according to a standard programme. As a result, drug treatment was started in 406 (0.5%) participants screened and blood pressure monitoring in another 1007 (1.3%). Of all patients taking antihypertensive drugs after the screening, 6399 (94.0%) had been diagnosed before screening, and of those whose blood pressure was monitored after the screening, 79.3% had been diagnosed before screening. CONCLUSIONS--At the blood pressure screening thresholds used, and when hypertension is defined by an overall clinical diagnosis, the results indicate that general practitioners can find and diagnose hypertensive patients with the case finding strategy.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":21307066,"openaccessinfo":{"externalids":{"MAG":"2079904743","ACL":null,"DOI":"10.1136\/bmj.302.6770.219","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.bmj.com\/content\/bmj\/302\/6770\/219.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Mass production method on artificial seedling production of hard clam Meretrix petechialis was developed indoor culture system. Spawning of adult clam (SL 65.8 \u00b1 8.4 mm) was induced using the combined method of air exposure and water temperature raising. The fertilized eggs were developed to D-shaped larvae after 17.7 hours at 27\u2103 and hatching rate was 6.1%. Shell length (SL) of D-shaped larvae was measured to be 131.4 \u00b1 2.6 \u03bcm and thereafter the larvae grew to the settled spats with SL 190.2 \u00b1 7.5 \u03bcm in 4 days. Estimated survival rate of settled spats was 48.1%. Spat collection on 130,000 spats with SL 0.19 \u00b1 0.01 mm performed conducted by sand bottom circulation filtering method. Collected spats grew up to 3.1 \u00b1 0.8 mm in 46 days, 6.6 \u00b1 1.8 mm in 87 days, and 10.5 \u00b1 0.9 mm in 114 days. The relative growth between SL and shell height (SH) was calculated to be SH = 0.8501SL + 0.0196 (R 2 = 0.9987) during the whole spat period. During spats rearing, they were suffered from one time of mass mortality at SL 3.1 mm, but 51,000 spats were finally survived with the rate of 39.2% at 114 days of spat rearing in indoor tank system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":84205124,"openaccessinfo":{"externalids":{"MAG":"2045491721","ACL":null,"DOI":"10.9710\/KJM.2012.28.4.313","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study attempts to show the way and process Browning as a post-Romantic poet tries to overcome his \"morbid self-consciousness,\" finally coming to the threshold of \"the objective form.\" He begins his literary career worshipping Shelley as his mentor, but the High Romantic Poets' \"transcendental subjectivity\" which he inherited mainly from Wordsworth and Shelley works as a burden even in his early youth. In this context, the substance of romantic ideology is summed up in the first section of this paper in relation to the romantic imagination and romantic longings of such poets as Wordsworth and Shelley. And then, in the later sections, Browning's \"anxiety of influence\" and his enormous efforts to \"misread\" Shelley are examined, focusing mainly on his first long poem Pauline. Surrounded by the increasingly materializing bourgeois culture, Browning tries to establish his poetic subject and poetic identity by winning the struggle against his mentor Shelley. He reveals the passion and longings for being born anew as \"a strong poet,\" and enacts very complex textual strategies in Pauline in that context. On worshipping the sun god\/Shelley as his muse, Browning continually reveals the anxiety which derives from the loss of belief in the transcendental subjectivity. Therefore, the recognition that the poet's self may be only a fiction makes Pauline constructed as what Roland Barthes, and after him Isobel Armstrong, names \"a fractured text\" or \"a corrupt text\". Browning's dramatic monologue as an objective form has its root in the despair of the political liberal who has lost his belief in the mentor's romantic ideology. However, the very sense of loss, paradoxically, drives him to find out the harder, safer, and more reliable lyric form that could be a model for the later modernist poets.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":194216750,"openaccessinfo":{"externalids":{"MAG":"2221958302","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The stiffness moduli of polyethylenes covering a wide range of degrees of branching and molecular weights have been investigated from \u2212150\u00b0C. up to the melting points. Qualitatively, the stiffness temperature curves can be broken into three regions. The first of these is the very low temperature region which extends from \u2212150 up to about \u221250\u00b0C. In this temperature region, all of the polymers have the same stiffness at a given temperature, although they do not have the same density. The second region extends from about \u221250\u00b0 up to the melting region. In this region, it is generally true that the stiffness is a function of the density alone. This is the case even though the temperatures at which polymers have equal densities are different. There are exceptions, however. It has been found that extremely high molecular weight polymers have higher stiffness than would be expected from their densities. Presumably, this arises directly from the very high molecular weight. It has further been found that highly crystalline polyethylenes increase in density upon annealing, but show little increase in stiffness or degree of crystallinity as measured by x-rays. This may well arise from the removal of small voids or flaws on i Annealing, the removal of which would increase density but not affect stiffness or crystallinity. The third region of the stiffness-temperature curves is the melting region. As expected, the stiffness curves reflect the higher melting points of the more linear resins. The stiffness curves also qualitatively indicate the randomness of branching. Polymers which are nonrandomly branched suffer a more gradual decrease of stiffness with temperature, reflecting a broader melting range than the more randomlybranched polymers. This effect probably arises from a broader distribution of crystallite sizes in the nonrandomly branched polymers. Unlike any other crystalline polymer which has been examined, the stiffness-temperature curves for polyethylene do not exhibit evidence of a sharp glass transition temperature. Rather, polethylene appears to undergo a gradual \"thawing\" from about \u221250\u00b0C. up to within a few degrees of the melting point.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":96623877,"openaccessinfo":{"externalids":{"MAG":"2058507229","ACL":null,"DOI":"10.1002\/POL.1958.1203212516","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mr. J. F. O'MALLEY referring to the rarity of lipomata of the larynx, said that when he looked up the literature a few years ago he could find records of only thirteen cases. Various tumours grew at the lower part of the pharynx and base of the tongue which were not entitled to be classed among lipomata of the larynx, as the latter usually grew in the ary-epiglottidean fold. In a case of his own the patient had at times very distressing dyspncea on undue exertion. The lipoma could be seen dropping down between the vocal cords and acting as a ball-valve. If it had been allowed to remain there much longer the patient inight have been suffocated. Dr. IRWIN MOORE reminded members of a contribution on this subject published in the Proceedings of the Section of Pathology, by Professor Shattock,' on a large","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32126352,"openaccessinfo":{"externalids":{"MAG":"1644276662","ACL":null,"DOI":"10.1177\/003591572301600714","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003591572301600714","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Traditional computer systems based on the WIMP paradigm (Window, Icon, Menu, Pointer) have shown potential benefits at school (e.g. for web browsing). On the other hand, they are not well suited as soon as hands-on and collaborative activities are targeted. We present CARDS, a Mixed-Reality system that combines together physical and digital objects in a seamless workspace to foster active and collaborative learning. We describe the design process based on a participatory approach with researchers, teachers, and pupils. We then present and discuss the results of a user study that tends to show that CARDS has a good educational potential for the targeted activities.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":207959998,"openaccessinfo":{"externalids":{"MAG":"2980524534","ACL":null,"DOI":"10.1145\/3343055.3359721","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.inria.fr\/hal-02313463\/file\/ISS_Giraudeau.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"A wide range of film materials, suitable for the fabrication of interference optics for the middle-IR range, was investigated. The selected film pair (YF3\u2014ZnS) had minimal internal porosity, low mechanical stresses, and good adhesion to substrates made of quartz, fluorite, barium fluoride, and leucosapphire. Experiments were used to determine the optimal film deposition procedures so as to minimise the residual microporosity, mechanical stresses, and losses resulting from diffuse scattering and absorption. Highly reflecting and output mirrors were made for the middle-IR range, as well as mirrors for an optical parametric oscillator (\u03bb=3.5\u201312 mm) and antireflection coatings for a nonlinear GaSe crystal. The optical strength of such coatings was 25\u201330 J cm-2. The interference optics developed in this way was used in an optical parametric oscillator with a GaSe crystal emitting at 4.2 mm when pumped with \u03bb = 2.12 \u03bcm radiation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250910759,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1070\/QE1997v027n02ABEH000889","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is established that a remainder of a non-locally compact topological group G has the Baire property if and only if the space G is not \u010cech-complete. We also show that if G is a non-locally compact topological group of countable tightness, then either G is submetrizable, or G is the \u010cech-Stone remainder of an arbitrary remainder Y of G. It follows that if G and H are non-submetrizable topological groups of countable tightness such that some remainders of G and H are homeomorphic, then the spaces G and H are homeomorphic. Some other corollaries and related results are presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73631892,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Establishing sustainable economic growth within a developing country requires the presence of a strong research infrastructure. The research infrastructure within a country is strengthened as researchers both within as well as outside the country collaborate with each other. The collaboration of researchers has been aided within developing countries with the adoption of electronic scholarly communication initiatives. While there have been numerous investigations of the use of electronic journals and databases in developing countries, there has been a woeful lack of investigation of the value and use of these information tools in any specific developing country. Moreover, few studies deal specifically with the scholarly communication needs of the research patron and how these needs reinforce or counteract the needs of researchers. With the belief that not all developing countries are alike and that the scholarly communication needs of researchers often differ from the needs of research patrons, we assess the value of different forms of access to electronic scholarly communication. More specifically, our concern is whether donated access or open access to scholarly communication is best suited to meet the needs of researchers, librarians, and research patrons. Our assessment reveals that with respect to creating sustainable economic growth through the application of research, open access scholarly communication initiatives possess the highest potential benefit from the perspective of the researcher, and furthers economic growth goals.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":150589906,"openaccessinfo":{"externalids":{"MAG":"139250216","ACL":null,"DOI":"10.2139\/ssrn.1912192","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"[reaction: see text] A wide spectrum of alcohols and phenols are readily transformed to the corresponding 2-tetrahydrofuranyl ethers in good to excellent yields using CrCl2 and CCl4 in THF under nearly neutral conditions at room temperature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21308926,"openaccessinfo":{"externalids":{"MAG":"1970001849","ACL":null,"DOI":"10.1021\/OL991332F","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Leibniz denies that the actual world possesses the per se unity of a substance. Instead, he seems to hold, the world is limited to the mind-dependent unity of an aggregate. Against this answer, criticized by Kant in his Inaugural Dissertation, I argue that for Leibniz the unity of the actual world is not grounded simply in God's perception of relations among created substances but in the common dependence of those substances on a unitary cause. First, the actual world is one because every created substance is continuously dependent on God for its perfection. Without being the soul of the world, God is an emanative cause through which the created world is unified. Second, every substance is a unique \"concentration\" of an ideal world that is God's model for creation. Consequently, while extensionally many, created substances are versions of the same one world chosen by God for creation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":248311165,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5840\/leibniz2021312","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this paper is to elucidate surgical indication and limitation for severe hypertensive intracerebral hemorrhage in the basal ganglia (HIH) with a view toward good functional outcome. Materials were 32 patients of severe basal ganglionic hemorrhage (HIH). Neurological grading (G) for HIH, reported by Kanaya et al. in 1978, was applied. Grading on admission in 11 patients with conservative treatment was G-4a in 2, G-4b in 3 and, G-5 in 6. Preoperative grading in 21 patients with surgical treatment was G-4a in 9, G-4b in 8 and G-5 in 4. G-4a revealed semicoma without herniation signs, G-4b semicoma with herniation signs and G-5 deep coma. The interval from the onset of HIH to hematoma evacuation was from 3 to 10 hours in 14 patients, from 17 to 23 hours in 5, 44 hours in one and 5 days in one. Functional outcomes at hospital discharge were classified as follows: self-managing (SM); partially dependent (PD); fully dependent (FD); vegetative (V); dead (D). Factors which would have influenced functional outcomes were studied and the results follow. All 11 patients with conservative treatment died. On the contrary, in 21 patients with surgical treatment, the outcomes were SM in 2 patients, PD in 3, FD in 11, V in one and D in 4. Death in the 4 patients was caused by fatal complications from 8 to 24 days after the operation. In 17 surviving patients with surgical treatment, (a) Mean age of the SM or PD patients was 45 years, and that of FD or V patients was 55 years.(ABSTRACT TRUNCATED AT 250 WORDS)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41902514,"openaccessinfo":{"externalids":{"MAG":"2412197416","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A reflective all-optical switching based on a metallic slab coated by nonlinear optical materials with sinusoidal topography has been proposed and numerically investigated. The calculation shows the dependence of signal light intensity on the pump light intensity is a clear bistable curve, which results in a significant switch effect. This configuration shows a great advantages of simpler structure, lower requirement of pump light intensity, and higher contrast ratio of signal light.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":30794061,"openaccessinfo":{"externalids":{"MAG":"2117741136","ACL":null,"DOI":"10.1109\/CLEOPR.2009.5292191","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is shown that a two-dimensional topological insulator can be realized and the band topology (equivalently, the edge states) may be further controlled by charge doping in an ultrathin SnTe film with a defect superstructure. Based on first-principles density functional theory (DFT), we predict that a Sn-Te bilayer, if exfoliated from three-dimensional bulk SnTe in the (1\u20091\u20091) direction, has a trivial band topology in its pristine form, but is made topologically nontrivial by introducing an appropriate array of defects. The emergence of the topological state is ascribed to the formation of topologically nontrivial narrow bands near the Fermi level by spin\u2013orbit splitting of defect-induced bands. In addition, we demonstrate that a transition between a topological insulator and a normal insulator is possible under the electron or hole doping which can be useful for controlling the topological edge states.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30413049,"openaccessinfo":{"externalids":{"MAG":"1976277076","ACL":null,"DOI":"10.1088\/0953-8984\/26\/23\/235504","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We evaluated the inflammatory indices according to the fever duration in children with Kawasaki disease (KD), and determined duration when the inflammatory processes in KD reach their peak. Children with KD (n=152) were classified into 7 groups according to fever duration: at the third day or earlier (n=20), fourth (n=33), fifth (n=46), sixth (n=15), seventh (n=15), eighth (n=9), and at the ninth day or later after fever onset (n= 14). The levels of various laboratory indices were determined 3 times: before, 24 hr and 7 days after intravenous immunoglobulin administration (2 g\/kg). WBC and neutrophil counts, and C-reactive protein level were the highest at the sixth day. Levels of hemoglobin, albumin, and high density lipoprotein cholestrol were the lowest at the sixth day. Although these indices were not significant statistically between groups, the indices showed either bell-shaped or U-shaped distribution of which peak or trench were at the sixth day. These findiugs showed that the inflammatory processes in KD reach peak on the sixth day of fever onset. This finding is important because a higher single-dose intravenous immunoglobulin treatment before the peak day may help reduce the coronary artery lesions in KD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12751548,"openaccessinfo":{"externalids":{"MAG":"2165124543","ACL":null,"DOI":"10.3346\/jkms.2004.19.4.501","PubMedCentral":"2816880","ArXiv":null},"license":"CCBYNC","url":"https:\/\/europepmc.org\/articles\/pmc2816880?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This chapter provides a survey of studies concerning the relationship between crude oil prices and other energy commodities such as coal and natural gas. Although such an assessment demands an interdisciplinary approach to provide readers with important background information, the approach taken here is based upon the economics of the energy market. The empirical studies summarized here can be categorized into three groups: time series studies analyzing market integration between oil and other energy commodities, studies that examine the predictive content of futures prices for energy, and the role of tail risk in explaining price volatilities of oil and other energy commodities. Several suggestions for future research are offered.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":210144372,"openaccessinfo":{"externalids":{"MAG":"2994718145","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The computational requirements and accuracy of two methods for finding the intersection of Bezier surfaces are examined. In both methods, the existence of an intersection curve is confirmed by using the convex hull property of such surfaces. The first method evaluates the intersection by recursive subdivision of two patches with overlapping hulls. The second method detects a point on the intersection curve and then incrementally traces the intersection in the parametric spaces of the two surfaces. With both methods, the intersection of a pair of first-order planar patches must be solved analytically. The intersection is approximated by first-order Bezier patches in the first case and by planar triangles in the second. Overall, the method of incremental tracing is shown to give more accurate results than the method of recursive subdivision.<>","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":9035916,"openaccessinfo":{"externalids":{"MAG":"1997522605","ACL":null,"DOI":"10.1109\/38.45810","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Spam content is surging with an explosive increase of user generated content (UGC) on the Internet. Spammers often insert popular keywords or simply copy and paste recent articles from the Web with spam links inserted, attempting to disable content-based detection. In order to effectively detect spam in user generated content, we first conduct a comprehensive analysis of spamming activities on a large commercial UGC site in 325 days covering over 6 million posts and nearly 400 thousand users. Our analysis shows that UGC spammers exhibit unique non-textual patterns, such as posting activities, advertised spam link metrics, and spam hosting behaviors. Based on these non-textual features, we show via several classification methods that a high detection rate could be achieved offline. These results further motivate us to develop a runtime scheme, BARS, to detect spam posts based on these spamming patterns. The experimental results demonstrate the effectiveness and robustness of BARS.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":803818,"openaccessinfo":{"externalids":{"MAG":"2089077498","ACL":null,"DOI":"10.1109\/ICDCS.2012.40","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Some gyrocommutative gyrogroups, also known as Bruck loops or K-loops, admit scalar multiplication, turning themselves into gyrovector spaces. The latter, in turn, form the setting for hyperbolic geometry just as vector spaces form the setting for Euclidean geometry. In classical mechanics the centroid of a triangle in velocity space is the velocity of the center of momentum of three massive objects with equal masses located at the triangle vertices. Employing gyrovector space techniques we find in this article that, in full analogy, the centroid of a hyperbolic triangle in relativity velocity space is the velocity of the center of momentum of three massive objects with equal rest masses located at the triangle vertices. Being guided by the relativistic mass correction of moving massive objects in special relativity theory, we express the hyperbolic triangle centroid in terms of the triangle vertices, resulting in a novel hyperbolic triangle centroid identity that captures remarkable analogies with its Euclidean counterpart.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":12809443,"openaccessinfo":{"externalids":{"MAG":"170920041","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An effort has been made to extend the matrix-oriented MATLAB syntax so that a generic expert system development environment can be incorporated into the control environment. Knowledge constructs such as rules and facts could then be handled by the language parser. The aim is to provide an integrated environment for coupling numeric and symbolic processing. A control system design package that can provide such an integrated environment is described. The issue of coupling numeric and symbolic computation, knowledge representation, and inference mechanism is examined.<>","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":61115751,"openaccessinfo":{"externalids":{"MAG":"1981714592","ACL":null,"DOI":"10.1109\/CACSD.1992.274438","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nCognitive remediation therapy (CRT) has been used with adults with anorexia nervosa (AN) in individual and group formats; however, evaluation of CRT with adolescents in this population is very limited.\n\n\nMETHOD\nSeven CRT groups were carried out with a total of 30 adolescents with AN. Adolescents' cognitive flexibility and motivation was assessed before and after the group, and they completed qualitative questionnaires after the group to determine their perceptions.\n\n\nRESULTS\nThere was a small effect size in self-reported cognitive flexibility post group. Adolescents found the group interesting and useful; however, some wanted more support with application to real life.\n\n\nDISCUSSION\nCognitive remediation therapy has the potential to be used with adolescents with AN. More research is needed to determine if CRT is beneficial for young people with AN.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":24003835,"openaccessinfo":{"externalids":{"MAG":"1555834540","ACL":null,"DOI":"10.1002\/erv.2176","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An international group of 30 Quaternary scientists studying the last interglacial in the Arctic met recently to share regional information and to begin the compilation of paleoclimatic information on a hemispheric scale. The NATO Advanced Studies Workshop was held in Hanstholm, Denmark. \n \nThe last interglacial (s.s.) has been identified at sites across the Arctic, as have other discrete intervals later in stage 5. The development of hemispheric data sets requires international programs that foster the exchange of field-based paleoclimate data and increased communication between field researchers and the modeling community. Toward that goal, LIGA (The Working Group on the Last Interglacial in the Arctic and Subarctic) was formed to foster the development of a global-scale data base and to serve as an interface between field-based Quaternary scientists and ongoing regional programs addressing the field record of the last interglacial (for example, PONAM, CELIA, SOVPEC, PALE), and the climate-modeling community.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129760146,"openaccessinfo":{"externalids":{"MAG":"1916518363","ACL":null,"DOI":"10.1029\/90EO10231","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Platelet rich plasma (PRP) is one of the new innovations of surgery today and is a new approach to tissue regeneration. It is helpful in both hard and soft tissue healing. PRP is derived from autologous blood and is a reservoir of various growth factors which are important for tissue repair. In the field of surgery, it tends to give an added advantage by both reducing bleeding and also helping in wound healing or tissue repair. Various studies have been carried out on humans to show the application and benefits of PRP in dentistry (especially enhancing healing of extraction sockets, implant surgery, periodontal surgery, bone regeneration etc). The use of PRP has also been proposed in the treatment of bisphosphonaterelated osteoradionecrosis of the jaw (BRONJ), as a better treatment modality as compared to the conventional methods. The main aim of this short narrative review is to 1) create awareness about what is PRP, 2) its methods of preparation, 3) various clinical applications and its promising results. As PRP is an autologous preparation, it is free from the potential risks associated with any other grafts. It definitely holds a promise in near future. However, more RCTs are still required to support its evidence. In this review, articles were searched online in recent journals by using certain relevant keywords regarding the clinical applications of PRP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30413778,"openaccessinfo":{"externalids":{"MAG":"2954249844","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"abstract The practice of intercropping pearl millet with cowpea is widespread among subsistence farmers in northern Namibia. In this region, the scarce and erratic rainfall may enhance competition for the limited soil water between intercropped plants. Trials were conducted on a field of the University of Namibia (on-station) and on a farmer's field (off-station) to determine the effects of competition between pearl millet and cowpea on the water sources and plant growth of each crop. The deuterium analysis showed that pearl millet, intercropped with cowpea, significantly increased its dependence on the recently supplied labeled irrigation water. Intercropped cowpea also showed an increased trend of the dependence but it was not statistically significant. At the university field, intercropped pearl millet showed higher dependence on the irrigation water than monocropped pearl millet. At the farmer's field, the dependence of intercropped pearl millet on the irrigation water was low in the pearl millet-dominant zone. In contrast, the dependence on the irrigation water was high in the cowpea-dominant zone, indicating that the dependence on the irrigation water changes according to the size of the pearl millet canopy. The water sources of cowpea did not show a significant difference at either pearl millet-dominant or cowpea-dominant zone, indicating a stable water uptake trend under competitive conditions. Competition with cowpea significantly increased the root-weight density of intercropped pearl millet in the deep soil layers, but decreased that in the shallow layers. The root-weight density of intercropped cowpea, however, was reduced in most of the soil layers. In conclusion, cowpea has a higher ability to acquire existing soil water, forcing pearl millet to develop deep roots and shift to the surface irrigation water.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":83709485,"openaccessinfo":{"externalids":{"MAG":"1980506797","ACL":null,"DOI":"10.1626\/pps.9.355","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1626\/pps.9.355?needAccess=true&role=button","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Myeloproliferative neoplasms (MPNs) are clonal disorders of the hematopoietic stem cell. Classical BCR\/ABL-negative MPNs include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Thrombotic events are a major cause of morbidity and mortality in these patients. Pathogenesis of blood clotting activation involves various abnormalities of platelets, erythrocytes, and leukocytes, as well as dysfunctions of endothelial cells. Patients with MPN can be stratified in \"high risk\" or \"low risk\" of thrombosis according to established risk factors. ET and PV clinical management is highly dependent on the patient's thrombotic risk, and a risk-oriented management strategy to treat these diseases is strongly recommended. In this review, we give an overview of risk factors, pathogenesis, and thrombosis prevention and treatment in MPN.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231936284,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1055\/a-1334-3259","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1055\/a-1334-3259","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"AbstRAct This chapter undertakes a meta-analysis of the published literature on e-commerce in developing economies (DEs). The aim is to take stock of the literature, identify enduring research themes, classify the existing work based on such themes and review the theoretical and conceptual approaches used. The analysis covers 245 articles published between 1993 and 2006 in 76 different journals on electronic commerce, information systems, global information technology, development and developing countries. The findings indicate that the research area is rapidly growing and relatively well-spread across the assessment of e-commerce potential and its adoption and implementation issues in DEs. We make a case for future research to focus on developing a broad development perspective of e-commerce benefits and a strategic understanding of how to achieve and sustain these benefits. The chapter thus serves both as a synthesis of current research, and as a road map providing future directions for both academics and practitioners.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262832346,"openaccessinfo":{"externalids":{"MAG":"2119896050","ACL":null,"DOI":"10.4018\/978-1-60566-100-1.CH001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Neonatal hypoxic-ischemic encephalopathy (HIE) is a devastating condition that may result in death or severe neurologic deficits in children. Neuroimaging with cranial ultrasound (US), computed tomography and magnetic resonance imaging are valuable tools in the workup of patients with HIE. The pattern of brain injury depends on the severity and duration of hypoxia and degree of brain maturation. Mild to moderate HI injury results in periventricular leukomalacia and germinal matrix bleed in preterm neonates, and parasagittal watershed infarcts in full-term neonates. Severe HI injury involves deep gray matter in both term and preterm infants. Treatment of HIE is largely supportive. The current article reviews the etiopathophysiology and clinical manifestations of HIE, role of imaging in the evaluation of the condition, patterns of brain injury in term and preterm neonates, the treatment and the prognosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35870562,"openaccessinfo":{"externalids":{"MAG":"2611041296","ACL":null,"DOI":"10.4103\/1817-1745.205646","PubMedCentral":"5437770","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/europepmc.org\/articles\/pmc5437770","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Withdrawal delirium in alcohol dependence usually lasts 48 to 72 hours. However, certain factors can prolong delirium. We report a 39-year-old man with long-standing alcohol use who presented with delirium, which failed to resolve with treatment. On evaluation, he was found to have AIDS and limbic encephalitis due to herpes simplex virus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9775765,"openaccessinfo":{"externalids":{"MAG":"2439921493","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"857 non-dermatologic patients were patch-tested with the Finn-Chamber-technique. The sequent testings under identical conditions were made after 3-12 months. Readings were done after 24, 72, 96 hours and later. During the first test-series we found 44 reactions to be positive, 20 remained identical during repetition-testings, 7 became negative and 36 positive reactions appeared. So reproducibility was 46% for the positive results of the first testing serie.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38751709,"openaccessinfo":{"externalids":{"MAG":"2401708839","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The expected Euler characteristic (EEC) curve of excursion sets of a Gaussian random field is used to approximate the distribution of its supremum for high thresholds. Viewed as a function of the excursion threshold, the EEC is expressed by the Gaussian kinematic formula (GKF) as a linear function of the Lipschitz-Killing curvatures (LKCs) of the field, which solely depend on the domain and covariance function of the field. So far its use for non-stationary Gaussian fields over non-trivial domains has been limited because in this case the LKCs are difficult to estimate. In this paper, consistent estimators of the LKCs are proposed as linear projections of \"pinned\" observed Euler characteristic curves and a linear parametric estimator of the EEC curve is obtained, which is more efficient than its nonparametric counterpart for repeated observations. A multiplier bootstrap modification reduces the variance of the estimator, and allows estimation of LKCs and EEC of the limiting field of non-Gaussian fields satisfying a functional CLT. The proposed methods are evaluated using simulations of 2D fields and illustrated in thresholding of 3D fMRI brain activation maps and cosmological simulations on the 2-sphere.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":199472701,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article considers newspapers' role in shaping the sociotechnical imaginaries of touch, and emerging technologies that digitally mediate touch. It examines the discourses of touch and personal relationships at a distance that circulated in major British broadsheet newspapers during the 2020 outbreak of coronavirus disease-19, alongside dominant narratives of touch and remote communication in the previous 5\u2009years. In doing so, the article demonstrates how existing discourses of touch and remote communication intensified during the pandemic, while imaginations of remote touch narrowed. The sociotechnical imaginaries of digital touch matter because they illuminate the kinds of social relations touch technologies are perceived to forge, maintain or deny.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":252034506,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/14614448221113922","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/discovery.ucl.ac.uk\/10152949\/1\/complete%20NMS%20covid%20paper%20.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The epidermal growth factor (EGF)-like domain of the bovine blood coagulation factor IX (45-87) carrying glucose at Ser(53) was synthesized by a solid-phase method using 9-fluorenylmethoxycarbonyl (Fmoc)-amino acids. The introduction of Ser(53) was carried out using the benzotriazolyl ester of Fmoc-serine carrying an unmasked glucose. The remaining sequence was also introduced using the benzotriazolyl ester. HPLC analysis of the crude peptide shows that acylation of the free hydroxyl group of the glucose was not significant, demonstrating that the amino acid carrying an unmasked carbohydrate is a useful building block for solid-phase synthesis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27842434,"openaccessinfo":{"externalids":{"MAG":"2136355030","ACL":null,"DOI":"10.1039\/b312413d","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ir.library.osaka-u.ac.jp\/repo\/ouka\/all\/3295\/obc_2_1_133.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Objectives Anti-vascular endothelial growth factor (anti-VEGF) drugs delivered intravitreally have been proven effective and safe for the treatment of patients diagnosed with neovascular age-related macular degeneration (ARMD). This study evaluated the short-term biologic efficacy and safety of multiple intravitreal injections of bevacizumab in patients with neovascular ARMD. Methods A prospective, interventional, placebo-controlled, randomized clinical trial was done involving patients with active subfoveal neovascular ARMD. Excluded were patients with significant media opacity, concomitant retinal\/ocular diseases, previous intravitreal injections, recent laser treatment or intraocular surgery, and contraindications to the drug. Demographic data were taken and a complete ocular examination, fluorescein angiogram (FA), and optical coherence tomogram (OCT) were performed. Patients received either 3 monthly intravitreal injections of 1.25mg bevacizumab or sham injections. Best-corrected visual acuity (BCVA) and central macular thickness were recorded at baseline, 2, 4, 8, and 12 weeks follow-up. Ocular\/Periocular or systemic drug-related side effects or toxicities and iatrogenic complications were noted. Results Thirty eyes (15 per group) were included in the final analysis. Both treatment and control groups were comparable in baseline characteristics. There was a significant increase in the mean visual acuity (p < 0.001) in eyes treated with bevacizumab across all time periods. The average gain at the end of the study was 11.6 letters. This paralleled a similar significant decrease in central macular thickness for the treatment group (p < 0.02). No major ocular adverse events were noted. Conclusion This study supported the growing body of evidence that intravitreal injections of bevacizumab 1.25 mg result in short-term anatomical as well as functional improvement with minimal adverse events in patients with neovascular ARMD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6823085,"openaccessinfo":{"externalids":{"MAG":"3048250952","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Patients with cirrhosis are frequently malnourished and this has a detrimental effect on outcome in terms of complications, survival after liver transplantation and overall liver-related mortality. The detection of malnutrition and its active management is, therefore, pivotal to these patients' well-being and survival. The aim of this study was to design and develop a simple, nutritional screening tool for use in patients with cirrhosis -The Royal Free Nutritional Prioritising Tool (RFH-NPT)\u2014and to validate its use against the Royal Free Hospital Global Assessment (RFH-GA) which is the accepted gold standard for nutritional assessment of cirrhotic patients in the UK. Methods The RFH-NPT was devised and piloted; interobserver performance agreement was excellent. Validation was undertaken in a cohort of patients with cirrhosis on transplant units throughout the UK and Southern Ireland. Patients' nutritional status was determined and categorised, by nursing staff, using the RFH-NPT (completion time 3\u2005min). The results were compared with the categorisation of nutritional status determined by dietitians using the RFH-GA (completion time 45\u2005min). The analysis of descriptive data, cross-tabulation, performance variables, 95% CIs and \u03ba values were calculated using standard methods. \u03ba Values were interpreted according to Altman, 1999. Results The patient population comprised 133 patients with cirrhosis (98 men: 35 women; mean [range] age 56 [23\u201373]\u2005yr). Overall 49 (37 %) patients were classified, using the RFH-GA, as adequately nourished; 46 (35%) as moderately malnourished and 38 (29%) as severely malnourished. The RFH-NPT identified patients who were at high risk for malnutrition with a diagnostic sensitivity of 100% (95% CI 89 to 100) and specificity of 73% (95% CI 63 to 81) (\u03ba value 0.41, 95% CI 29 to 53). Conclusion The RFH-NPT is a simple, quick and validated method for identifying patients with cirrhosis who at high risk for malnutrition. Further multicentre validation is warranted.Abstract PMO-040 Figure 1 Competing interests None declared.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":79606906,"openaccessinfo":{"externalids":{"MAG":"2328367998","ACL":null,"DOI":"10.1136\/gutjnl-2012-302514b.42","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/gut.bmj.com\/content\/gutjnl\/61\/Suppl_2\/A90.3.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The Livelihoods and Landscapes Strategy (LLS) seeks to influence the ways in which forests are managed and used. It intends to leverage real and meaningful improvements in the livelihoods of the rural poor, enhance biodiversity conservation, and ensure the sustainable supply of forest goods and services. These goals are founded on a strong recognition of the close relationship between people's economic wellbeing, and the status and integrity of forests. As described in this publication, economic factors have an extremely important influence on forest livelihoods and landscapes. The Markets & Incentives theme of LLS aims to identify how economic and financial tools can be used to support more sustainable forest use and management, while also increasing the incomes and livelihood security of the rural poor.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":168670065,"openaccessinfo":{"externalids":{"MAG":"2761641975","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective. Bacteremia is relatively common in patients with skin and skin-structure infection (SSSI) severe enough to require hospitalization. We used selected demographic and clinical characteristics easily assessable at initial evaluation to develop a model for the early identification of patients with SSSI who are at higher risk for bacteremia. Participants. A large database of adults hospitalized with SSSI at 97 hospitals in the United States during the period from 2003 through 2007 and from whom blood samples were obtained for culture at admission. Methods. We compared selected candidate predictor variables for patients shown to have bacteremia and patients with no demonstrated bacteremia. Using stepwise logistic regression to identify independent risk factors for bacteremia, we derived a model by using 75% of a randomly split cohort, converted the model coefficients into a risk score system, and then we validated it by using the remaining 25% of the cohort. Results. Bacteremia was documented in 1,021 (11.7%) of the 8,747 eligible patients. Independent predictors of bacteremia (P<.001) were infected device or prosthesis, respiratory rate less than 10 or more than 29 breaths per minute, pulse rate less than 49 or more than 125 beats per minute, temperature less than 35.6\u00b0C or at least 38.0\u00b0C, white blood cell band percentage of 7% or more, white blood cell count greater than 11 x 109\/L, healthcare-associated infection, male sex, and older age. The bacteremia rates ranged from 3.7% (lowest decile) to 30.6% (highest decile) (P< .001). The model C statistic was 0.71; the Hosmer-Lemeshow test P value was .36, indicating excellent model calibration. Conclusions. Using data available at hospital admission, we developed a risk score that differentiated SSSI patients at low risk for bacteremia from patients at high risk. This score may help clinicians identify patients who require more intensive monitoring or antimicrobial regimens appropriate for treating bacteremia.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":5276527,"openaccessinfo":{"externalids":{"MAG":"2021390558","ACL":null,"DOI":"10.1086\/654007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Aims Displaced femoral neck fractures (FNF) may be treated with partial (hemiarthroplasty, HA) or total hip arthroplasty (THA), with recent recommendations advising that THA be used in community\u2010ambulant patients. This study aims to determine the association between the proportion of FNF treated with THA and year of surgery, day of the week, surgeon practice, and private versus public hospitals, adjusting for known confounders. Patients and Methods Data from 67 620 patients in the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) from 1999 to 2016 inclusive were used to generate unadjusted and adjusted analyses of the associations between patient, time, surgeon and institution factors, and the proportion of FNF treated with THA. Results Overall, THA was used in 23.7% of patients. THA was more frequently used over time, in younger patients, in healthier patients, in cases performed on weekdays (adjusted odds ratio (OR) 1.27; 95% confidence interval (CI) 1.14 to 1.41), in private hospitals (adjusted OR 4.34; 95% CI 3.94 to 4.79) and by surgeons whose hip arthroplasty practice has a relatively higher proportion of elective patients (adjusted OR 1.65; 95% CI 1.49 to 1.83). Conclusion Practice variation exists in the proportion of FNF patients treated with THA due to variables other than patient factors. This may reflect variation in resources available and surgeon preference, and uncertainty regarding the relative indication.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":58621313,"openaccessinfo":{"externalids":{"MAG":"2908135989","ACL":null,"DOI":"10.1302\/0301-620X.101B1.BJJ-2018-0666.R1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study investigated the noradrenergic contribution during the cutaneous vasoconstrictor response to local cooling in the leg and forearm. On each limb, one site was perfused with Yoh\/Prop to block the postsynaptic adrenoceptors and another with Lactated Ringer's (control) using microdialysis. Blood flow was measured by Laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was calculated as LDF units divided by the mean arterial pressure. After baseline measures, skin was locally cooled to 24\u00b0C. Basal CVC was similar at all sites in the leg and forearm (all p > 0.1). During the first 10 min of local cooling, CVC was reduced in the leg (p < 0.005) and unchanged in the forearm control sites (p = 0.2). Yoh\/Prop induced an increased CVC in the leg and forearm to a similar level (39.2 \u00b1 11.5, and 41.3 \u00b1 3.3%CVC, respectively; p < 0.35). Late during local cooling, the vasoconstriction was attenuated in the leg and forearm at Yoh\/Prop (-38.2 \u00b1 5.3 -37.1 \u00b1 5.3%CVC, respectively; p = 0.5) compared to control sites (-69.1 \u00b1 5.8 vs. -54.5 \u00b1 6.4%CVC, respectively; p < 0.005). Noradrenergic contribution was greater in the leg than the forearm during the late vasoconstrictor response (p = 0.006). These data indicate that the leg skin can induce greater vasoconstriction than forearm during local cooling, possibly via higher noradrenergic sensitivity in the leg skin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4454603,"openaccessinfo":{"externalids":{"MAG":"2795341335","ACL":null,"DOI":"10.4149\/gpb_2017021","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.elis.sk\/download_file.php?product_id=5544&session_id=qpg4e107bghcgn4gk4dtbkfte2","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Cellular automaton algorithms, which operate on a starting digital image of a water-cement suspension, are described. The algorithms simulate the microstructure development process due to hydration reactions that occurs between cement and water. This paper describes the evolution of the cement model from a simple model, which treated the cement particles as single-phase materials, with a greatly simplified hydration chemistry, into a model which has many more chemical species and includes numerous reactions which eventually convert the viscous water-cement suspension into a rigid porous solid. Methods are presented for generating two- and three-dimensional images representing suspension initial conditions; these are derived from both micrographs of real cements and computer-based algorithms. The 2D initial images are based on the processing of backscattered electron and x-ray images of real cement suspensions. The 3D images employ either spheres to represent cement particles, or more realistic randomly shaped particles via an algorithm which smooths and thresholds a 3D lattice whose sites are initially populated with random white noise. A convenient measure of the point at which the initial paste turns into a solid material is the percolation threshold of the solids. Consideration of these models has already led to the prediction and subsequent experimental observation of a sharply defined onset of shear wave propagation, from ultrasonic measurements through hydrating cement slurries. The amount of hydration needed to reach the percolation threshold can be determined in the present simulations, and our results are compared with time of shear wave onset in actual cement slurries. Variants of the basic model provide insight into both early-time behaviour that is of primary interest to oil well cementing and the later-time microstructural properties that are of interest in the construction industry.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250845929,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0965-0393\/2\/4\/001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Adolescent sexuality is a relevant public health issue, as it affects risk to contract HIV and other sexually transmitted infections. The assessment of prevalence of sexual intercourse among adolescents may guide policies and programmes aimed at reducing the transmission of sexually transmitted infections among this age group. Using data from the Thailand Global School-Based Student Health Survey (GSHS) 2008, we assessed the prevalence of sexual intercourse in the last 12 months and its associated factors among adolescents (N = 2758). Overall the prevalence of sexual intercourse in the past 12 months was 11.0% (14.6% males and 7.6% females). Variables positively associated with the outcome in multivariable analysis were male gender (OR = 1.66; 95% CI 1.14\u2013242), older age, \u226515 years (OR = 2.60, 1.80\u20133.74), current alcohol use (OR = 2.22, 1.46\u20133.36), psychosocial distress (OR = 2.11, 1.44\u20133.09) and among females current smoking (OR = 5.47, 1.62\u201318.48), lifetime drug use (AOR = 4.35, 1.04\u201318.3) and lack of parental or guardian bonding (AOR = 0.51, 0.27\u20130.97). Efforts to control unhealthy lifestyles (substance use) and psychosocial distress may impact on adolescents' sexual activity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6174299,"openaccessinfo":{"externalids":{"MAG":"2070782186","ACL":null,"DOI":"10.1100\/2011\/532109","PubMedCentral":"3201681","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/tswj\/2011\/532109.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A new family of maximum distance separable (MDS) array codes is presented. The code arrays contain p information columns and r independent parity columns, where p is a prime. We give necessary and sufficient conditions for our codes to be MDS, and then prove that if p belongs to a certain class of primes these conditions are satisfied up to r\/spl les\/8. We also develop efficient decoding procedures for the case of two and three column errors, and any number of column erasures. Finally, we present upper and lower bounds on the average number of parity bits which have to be updated in an MDS code over GF(2\/sup m\/), following an update in a single information bit. We show that the upper bound obtained from our codes is close to the lower bound and does not depend on the size of the code symbols.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":1054449,"openaccessinfo":{"externalids":{"MAG":"2166011389","ACL":null,"DOI":"10.1109\/ISIT.1995.535761","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The association of erlotinib (ERL) with gemcitabine (GEM) is a promising combined therapy for advanced pancreatic cancer, but current protocols have only a modest impact on the overall survival of patients respect to GEM alone. Sequential treatment can improve the efficacy of this drug combination. Towards optimization of the drug combination, we simulated cell cycle progression during\/after treatment, based on the dynamics of checkpoint activation, with the probabilities of cell arrest or death in each cell cycle phase, applying a previously established experimental\/computational approach (Lupi et al. Cancer Res. 64: 2825; Ubezio et al Cancer Res. 69: 5234; Falcetta et al. PLoS Comput Biol. e1003293). The simulation gives the temporal evolution of cell flow through G1, S and G2M over subsequent division cycles, from which the time courses of cell cycle percentages and the number of cells in each cell generation were derived enabling a joint validation of the model with independent flow cytometric and time-lapse live-imaging experimental data, collected in time course experiments up to 96h with different concentrations of GEM (6h treatment) and ERL (48h treatment) with two pancreatic cell lines (BxPC-3 and capan-1). Analysis of the response to ERL treatment reveals that at cytostatic concentrations a partial G1 arrest mainly occurs after the first division following the start of treatment (gen 1 cells) while a stronger delay of the progression in S phase is active also before division (gen 0). The activity of G1 and S phase checkpoints were dose dependent and at higher cytotoxic concentrations we observed a near complete arrest in both G1 and S phases while most cell deaths were in phase S in gen 0. After treatment discontinuation, while G1 blocked cells re-enter in cycle, S phase progression in gen 0 and gen 1 remained slow but without additional death events. The model of GEM demonstrated the activation of a strong delay in phase S shortly after the start of treatment, both in gen 0 and gen 1, already at non-cytotoxic concentrations, lasting several hours after treatment discontinuation, and thereafter progressively reduced, resulting in a wave of broadly semisynchronised cells traversing S and G2M phases in gen 0. At cytotoxic concentrations, part of the cells remained arrested in S phase and eventually died. A temporary delay in G1 was also demonstrated already at fairly low concentrations, acting only during exposure to the drug. Based on these models of GEM and ERL treatment, studies are ongoing to simulate the expected outcomes of sequential treatments. Preliminary analysis suggests that the GEM = > ERL sequence is particularly favourable in both cell lines when a cytostatic ERL concentration was given after a fairly cytototoxic GEM concentration when S phase progression resumed, by strengthening the long term cytostatic effects in S phase. Citation Format: Monica Lupi, Francesca Falcetta, Maurizio D9Incalci, Paolo Ubezio. In silico rendering of cell cycle progression of erlotinib and gemcitabine treatment in pancreatic cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3777. doi:10.1158\/1538-7445.AM2015-3777","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78817028,"openaccessinfo":{"externalids":{"MAG":"2564163366","ACL":null,"DOI":"10.1158\/1538-7445.AM2015-3777","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In political talk shows, one can sometimes hear that sanctions against Russia are the result of the \u00abCrimean Spring\u00bb in 2014 and the Crimea's return to its native Russian harbor, and if this had not happened, the relations between Russia and the West would be extremely good-neighborly, mutually beneficial and friendly... The counterargument runs as follows: the confrontation between Russia and the West has lasted for many centuries. It was in the past, remains nowadays and will continue in the future ...The purpose of the article is to analyze the confrontation between Russia and the West at the beginning of the 18th century, which was not only the continuation of the centuries-long confrontation between the parties to the conflict, but also revealed new motives of their rivalry. Earlier, the attack of the Swedish and German knights in the first half of the 13th century, Ivan IV's war against the Swedes, Livonians, Lithuanians and Poles in the second half of the 16th century and the struggle of the Tsardom of Muscovy against the Poles at the beginning of the 17th century took place during the periods of the Russian state's weakness. However, the confrontation between Peter I and united Europe in the Baltic region at the beginning of the 18th century unfolded at the time of Russia's strengthening, when it succeeded in regaining \u00abgrandfathers' and fathers'\u00bb lands and became a strong state in that geopolitically important region. The study is novel in that it considers this perspective to the problem. The relevance of the study is proved not only by the current state of relations between Russia and the West, in which unprecedented pressure on our country prevails in practically all spheres of the Russian state and society, but also by the fact that the struggle against modern Russia started when it rose from its knees and, overcoming the consequences of the USSR's collapse and the 1990's, declared an independent policy on the international stage. Drawing a parallel between the events taking place in Russian history 300 years ago and nowadays, the West's main and unchanging goal may be determined. This goal is slowing down the development of Russia and limiting its influence on international affairs. The authors conclude that both 300 years ago and now Russia can rely only on itself, its strong economy, powerful armed forces and the unity of the government and the people.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226470829,"openaccessinfo":{"externalids":{"MAG":"3047947230","ACL":null,"DOI":"10.5455\/jcmr.2020.11.02.11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This work presents an integrated multifunction antenna based on new traveling-wave (TW) antenna technologies that can handle multiple terrestrial and satellite communications on mobile platforms. The terrestrial omnidirectional part of the antenna has been demonstrated to have an ultrawide bandwidth over 100:1, with feasibility of 1000:1 or more. The antenna is miniaturized and low-cost, thus attractive for applications on automobiles and other small platforms. The basic design configurations and their measured performance, as well as details on a breadboard model covering terrestrial communications and GPS L1, are discussed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":6599933,"openaccessinfo":{"externalids":{"MAG":"2063217042","ACL":null,"DOI":"10.1109\/EUCAP.2012.6205824","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The 'Florida Yards & Neighborhoods' Information Kiosk' was developed as an outreach tool to provide 'Florida- Friendly Landscape Tips' through an interactive program running on a computer with a touch-screen monitor. The system was located at The Home Depot Garden Center, Pinellas Park, Florida from January 2000 to 10 April 2001, as a pilot project to determine whether the public will use this system to obtain landscape design and maintenance information. The number of users recorded at the kiosk averaged 204 per month during the 15 months it was at The Home Depot. On 10 April 2001, the kiosk was relocated to the Florida Botanical Gardens operated by Pinellas County Extension. Venues other than garden centers envisioned as appropriate for the kiosk include horticultural\/environmental exhibitions and festivals, shopping malls, lobbies of University of Florida\/IFAS Extension Offices, and other organizations involved with environmental education. Three counties and one city have plans to purchase and implement a kiosk. Several other organizations have indicated interest.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":197556421,"openaccessinfo":{"externalids":{"MAG":"2950370689","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The method of fabrication, an investigation and a comparison of the structure, size and shape of grains of a quaternary Cu-Ti-Zr-Ni alloy were investigated. Cu-based amorphous alloys have a high strength, ductility, fracture toughness, fatigue strength and excellent corrosion resistance in solutions such as H2SO4, NaOH, NaCl and HNO3. Samples of powders were prepared by mechanical alloying in a high-energy ball mill SPEX 8000. To obtain the amorphous structure of the Cu47Ti34Zr11Ni8 powder, various milling times were used. Finally, four samples for testing were obtained with pure Cu, Ti, Ni, Zr (99.99 %). The structure of the Cu47Ti34Zr11Ni8 powders was examined by X-ray diffraction (XRD) after 7 h, 8 h, 9 h and 10 h of milling time. The chemical composition, particle size and shape of the prepared powders were investigated by scanning electron microscopy (SEM). The microhardness was measured by using a Vickers hardness-testing machine with automatic track measurement. The fully amorphous powders were obtained after 10 h of milling. The prolonged time of milling resulted in an increased particle size and a changed shape of the powders. The highest microhardness was obtained for the amorphous samples. In further work the studied amorphous powders will be consolidated using spark-plasma sintering, which is an innovative method for the production of amorphous alloys.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54605414,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Individuals with Down syndrome should be adapted to society. As there are various projects to achieve this goal, one of them is establishing cafes where all waiters\/waitresses are individuals with syndrome. The Down Cafe is the one of these cafes that is located in Istanbul, Turkey. In such cafes, some of the tasks are quite hard to be performed by individuals with Down syndrome, such as taking orders. The waiters\/waitresses with Down syndrome need assistance by their voluntary mothers for such tasks, thus it is actually performed by their voluntary mothers. In this study, a novel user interface is modeled for individuals with Down syndrome to take orders. We then analyzed their emotion mode as they are using the prototype. The interface was tested with existing Down cafe aiters\/aitresses and findings were reported. We concluded that using novel assistive user interfaces for people with disabilities, personal assistance by their voluntary caregivers can be minimized as self sufficiency and degree of rehabilitation improves.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29172083,"openaccessinfo":{"externalids":{"MAG":"2586710776","ACL":null,"DOI":"10.1109\/SMC.2016.7844393","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many consider inequality in health unfair if it is caused by inequality within the healthcare system but less unfair when caused by individuals' health behaviour. However, healthcare systems are challenged when it comes to ensuring equal care for equal need. In Roemer's equality of opportunity theory, people have equal opportunity for obtaining something if obtaining it reflects their effort instead of their circumstances. Very little is known about how responsibility exerted by patients prior to illness affects the healthcare they are provided by the healthcare system. We aimed to apply Roemer's theory to an acute care setting where healthcare is most directly in the hands of the healthcare system in order to study the role of patient-exerted responsibility for their opportunities in the healthcare system. We operationalised the responsibility patients exert as Body Mass Index (BMI), smoking and alcohol habits, and their circumstances as demographics, socioeconomics, prognostic factors and year of discharge. Opportunity in healthcare was defined as patients' attainment of clinical guideline-recommended acute hospital care. In Roemer's theory, we detected inequality of opportunity as restricted attainment of healthcare was mainly associated with patients' circumstances, such as lower education, old age or living alone. We also identified a strong association with BMI; being underweight negatively affected patients' opportunities as it led to suboptimal healthcare, while the opposite was found for being overweight and, in particular, obese. Hence, patient-exerted responsibility affected patients' opportunities in healthcare, though perhaps in an unexpected way. This improved understanding of inequality may help to focus future research and, in the long term, support clinical and political efforts to achieve equal care for equal needs.\nPublished: Online March 2021.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":233778683,"openaccessinfo":{"externalids":{"MAG":"3144584848","ACL":null,"DOI":"10.5617\/NJHE.7822","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background.Osteoporosis is the fourth most common disease after cardiovascular diseases, cancer, and diabetes. All these diseases\u00a0 have\u00a0 common\u00a0 pathogenetic\u00a0 mechanisms\u00a0 associated\u00a0 with\u00a0 impaired\u00a0 cholesterol\u00a0 metabolism.\u00a0 In\u00a0 recent\u00a0 decades, the\u00a0 use\u00a0 of\u00a0 the\u00a0 key\u00a0 enzyme\u00a0 of\u00a0 cholesterol\u00a0 synthesis\u00a0 inhibitors \u2014\u00a0 statins,\u00a0 which\u00a0 can\u00a0 stimulate\u00a0 osteogenesis,\u00a0 has\u00a0 become widespread. However, statins affect the production of the vitamin D active form by reducing the production of testosterone and thus reducing the activity of 1\u03b1-hydroxylase. The combined use of statins and \u03b1-calcidol (\u03b1-C) for the osteoporosis prevention\u00a0 seems\u00a0 promising. The\u00a0 aim\u00a0 of\u00a0 the\u00a0 study was\u00a0 to\u00a0 evaluate\u00a0 the\u00a0 effect\u00a0 of\u00a0 long-term\u00a0 atorvastatin\u00a0 (ATV)\u00a0 and \u03b1-C administration on morphometric growth parameters and bone vascularization in the experiment. Materials and Methods. The experiment was conducted for three months on 120 laboratory male rats, which were injected daily intragastrically with ATV and \u03b1-C. After 90 days of the experiment, the animals were decapitated under ether anesthesia. For the study, the right femur and jawbone were taken from the animals. The rat bone sections were impregnated with silver, decalcified, and the histosections were stained according to van Gieson. The distribution of the studied features was evaluated according to the Shapiro-Wilk test. The differences were considered statistically significant at p<0.05. Results.It was found that ATV, both separately and together with \u03b1-C, increased the size of the newly formed bone in the endoostal and periosteal zones of the femur by 64.8; 40.4 and 15.8; 29.1%, respectively. The combined use of ATV and \u03b1-C had a positive effect on the growth of blood vessels in the femur (+23.4%). ATV increased the size of the newly formed bone from the periodontal and vestibular surfaces of the lower jaw by 18.3 and 29.5%, respectively. \u03b1-C potentiated the effect of ATV on the size of the newly formed bone tissue in the periodontal and vestibular growth zones of the mandibular bone by 10.1 and 15.0%, respectively. As for the number of vessels in the jawbone tissue, thanks to ATV, it increased by 17.2%, \u03b1-C had no effect. Conclusion. ATV increases the thickness of the newly formed bone layer in the growth areas of the femur and jawbone and increases the number of vessels in the jawbone. \u03b1-calcidol increases the number of vessels in the bone tissue of the femur and potentiates the effect of ATV on the jawbone growth zones. The combined use of ATV and \u03b1-C shows that they positively complement each other.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237752822,"openaccessinfo":{"externalids":{"MAG":"3178803483","ACL":null,"DOI":"10.21823\/2311-2905-2021-27-2-65-74","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/journal.rniito.org\/jour\/article\/download\/1646\/1097","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The long-term relationship between temperature and hydroclimate has remained uncertain due to the short length of instrumental measurements and inconsistent results from climate model simulations. This lack of understanding is particularly critical with regard to projected drought and flood risks. Here we assess warm-season co-variability patterns between temperature and hydroclimate over Europe back to 850 CE using instrumental measurements, tree-ring based reconstructions, and climate model simulations. We find that the temperature\u2013hydroclimate relationship in both the instrumental and reconstructed data turns more positive at lower frequencies, but less so in model simulations, with a dipole emerging between positive (warm and wet) and negative (warm and dry) associations in northern and southern Europe, respectively. Compared to instrumental data, models reveal a more negative co-variability across all timescales, while reconstructions exhibit a more positive co-variability. Despite the observed differences in the temperature\u2013hydroclimate co-variability patterns in instrumental, reconstructed and model simulated data, we find that all data types share relatively similar phase-relationships between temperature and hydroclimate, indicating the common influence of external forcing. The co-variability between temperature and soil moisture in the model simulations is overestimated, implying a possible overestimation of temperature-driven future drought risks.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":198746040,"openaccessinfo":{"externalids":{"MAG":"2955540732","ACL":null,"DOI":"10.1088\/1748-9326\/ab2c7e","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1088\/1748-9326\/ab2c7e","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In the Binary Networked Public Goods game, every player needs to decide if she participates in a public project whose utility is shared equally by the community. We study the problem of computing if there exists a pure strategy Nash equilibrium (PSNE) in such games. The problem is already known to be NP-complete. We provide fine-grained analysis of this problem under the lens of parameterized complexity theory. We consider various natural graph parameters and show either W[1]-hardness or exhibit an FPT algorithm. We finally exhibit some special graph classes, for example path, cycle, bi-clique, complete graph, etc., which always have a PSNE if the utility function of the players are fully homogeneous.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":227255210,"openaccessinfo":{"externalids":{"MAG":"3106803449","ACL":null,"DOI":"10.5555\/3535850.3535948","PubMedCentral":null,"ArXiv":"2012.01880"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Data sharing is crucial for building large datasets which in return are essential for developing and training accurate models in many contexts including smart cities, agriculture, and medical applications. However, shared data may leak private information, such as personal identifiers or location. Past research provides evidence that solely removing these identifiers through pseudonymization is not enough to ensure data privacy protection, since even the pseudonymized data may still contain information about the data provider. In this paper, we show that sensor data may leak a sensor's location even if the latter is not explicitly shared. Sensors are localized by linking sensor data with publicly available environmental data such as local weather. The proposed localization method relies on a machine learning model to predict weather data from sensor observations. Subsequently, the localization algorithm determines the sensor's location from the predicted weather trace using Bayesian filtering. We apply our approach to three real-world datasets where we (1) localize an ozone sensor given its readings, (2) localize a cow from activity parameters recorded with a tracker in the cow's reticulum, (3) localize solar panels based on their solar generation data. The achieved average localization accuracy of 5.68 km, 19.91 km, and 13.68 km on the above tasks, respectively, using data traces with a length of 365 days is remarkable. In addition, we introduce a mechanism, referred to as teleport, to protect location information in sensor data. The mechanism is based on deep models and masks the location by replacing the weather dependency with a different weather signature.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":250008794,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/iotdi54339.2022.00015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Planning and building legislation is often subjected to criticism \u2013 in Sweden and in other countries \u2013 especially in terms of process complexity and time. Legislation has a limited steering capability. It can be exemplified by studies where it was found that the practical application of planning provisions in detailed development plans (Caesar and Lindgren, 2009) and development agreements (Kalbro and Smith, 2008) often are outside the intentions of the legis-lation. We can thus find a gap between legislation and practice also in Sweden (Kalbro et al., 2012). Obviously, such a gap is not good for several reasons. It creates both legal uncertainty and lack of predictability.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153063504,"openaccessinfo":{"externalids":{"MAG":"588063372","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Studies have found high reproductive morbidity in many developing countries, with women opting to neither discuss their problems nor seek medical care. Among the reasons why women choose to suffer their affliction in silence is fear of being ostracized by fellow villagers, not knowing someone who can provide treatment, lack of time for treatment, and women's low status and corresponding cultural expectations of females. Many of the several hundred female patients attending a 2-week health camp organized in June 1995 by the Ministry of Health in Taplejung District were aware that they had gynecological and dermatological problems, but they had neither discussed it with their husbands nor sought treatment on their own. An even worse situation was observed in some villages in Bajura district. More than 20,000 patients were seen at the health camp by 30 doctors. Some patients came from Panchthar and Therathum districts. A similar health camp was recently organized in Myagdi and Pyuthan districts. The camp comprised comprehensive health services where major surgeries were also performed. In Taplejung, one-third of the 300 surgeries conducted were major. The experience of such health camps shows that people will seek help when good quality services are available and accessible.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261865304,"openaccessinfo":{"externalids":{"MAG":"2278940630","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Calcium carbide (CaC2) is a source of acetylene gas which is a well known nitrification inhibitor and converts into ethylene in the soil environment. Ethylene is a potent plant growth regulator and influences a number of biological processes from root growth to leaf senescence. A pot experiment was conducted to study the effect of a calcium carbide based formulation, Matrix-I (21% calcium carbide, 58% polyethylene and 21% plaster of paris), applied at 0, 7.5, 15 and 22.5 mg CaC2\u00a0kg-1\u00a0soil at 0, 4, 8 and 12 cm soil depth, on growth, yield and nitrogen uptake of wheat. Increasing the rate and application depth of Matrix-I, decreased wheat plant height and increased the number of tillers, biological yield, grain yield, 1,000-grains weight and nitrogen uptake by wheat grain and straw. However, when calcium carbide at 22.5 mg kg-1\u00a0soil was applied at greater soil depths, it inversely affected the economical yield of wheat. Comparatively maximum increase in yield parameters of wheat was observed when formulated calcium carbide was buried at 15 mg kg-1\u00a0soil at 8 cm soil depth. \n \n \u00a0 \n \n Key words: Wheat, calcium carbide, growth, nitrogen uptake.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86126237,"openaccessinfo":{"externalids":{"MAG":"2159158689","ACL":null,"DOI":"10.5897\/AJAR11.1420","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study has put emphasis on examinations and analyses of problems of civil engineer's wage system calculated by multiplying direct labor costs by the rate and factors affecting the wage. As the result of examining the Established Rules of the Fiscal Law involved, even though civil engineers were major technical human resource, they were classified into indirect labor and were paid by indirect labor expenses computed by multiplying direct labor costs by the rate. Distribution by the rate is difficult to control imbalance between contractors and subcontractors. It is also difficult to reflect the expertise and management abilities of civil engineers invested to the establishment and management for construction plans using high priced equipments and precision processing. This study has presented the need and introduction of the research on civil engineers' ordinary wage not multiplied by the rate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153152027,"openaccessinfo":{"externalids":{"MAG":"778646635","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Hematoporphyrin monomethyl ether (HMME) is a novel and promising second\u2010generation porphyrin\u2010related photosensitizer for photodynamic therapy (PDT). To study the effects of HMME PDT on choroidal neovascularization (CNV) in rats, the PDT was performed 20\u2003min after HMME bolus injection, which was investigated prior to the PDT by fluorescence microscopy with laser\u2010induced CNV, and delivered at an irradiance of 400, 600 and 1000\u2003mW\u2003cm\u22122 corresponding to a fluence of 36, 54, 90\u2003J\u2003cm\u22122 in PDT plan I (15\u2003mg\u2003kg\u22121 HMME). In PDT plan II (30\u2003mg\u2003kg\u22121 HMME), the laser had a constant irradiance of 600\u2003mW\u2003cm\u22122, which was delivered for 60, 90 or 150\u2003s, to also achieve total energy doses of 36, 54 or 90\u2003J\u2003cm\u22122. CNV closure rates assessed by fluorescein angiography and histologic damage to treated areas of choroid and retina varied as a function of the dose of HMME and of the activating light energy fluence. Endothelial cell labeled by platelet\/endothelial cell adhesion molecule\u20101 presented treated CNV lesions that were significantly reduced in size (P\u2003<\u20030.01). It can be concluded that PDT using HMME can effectively occlude CNV. HMME is a potentially useful photosensitizer for the reduction in CNV size of irradiated areas.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":30168990,"openaccessinfo":{"externalids":{"MAG":"2152003037","ACL":null,"DOI":"10.1111\/j.1751-1097.2010.00757.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A striking feature of local government reform in many Commonwealth countries has been a heavy reliance on structural reform, often in the form of forced local council amalgamation. This paper argues that the long-run success of structural change in local government hinges on several key factors, not least that voluntary rather than compulsory council mergers have a far greater chance of success. A second key ingredient resides in a high degree of local autonomy in both the composition and operation of decentralized governmental functions. A third vital factor lies in ensuring that revenue and tax assignment is sufficient to provide local government with financial autonomy. Finally, adequate powers of taxation need to be accorded to local government and this requires careful consideration of the types of taxes most suited to local government.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":56122213,"openaccessinfo":{"externalids":{"MAG":"1986805831","ACL":null,"DOI":"10.5130\/CJLG.V0I0.1102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Cognitive Profile of a Talented Foreign Language Learner. A Case Study The article examines a variety of cognitive individual variables of a talented foreign language learner. The research complies with the qualitative and quantitative criteria of choice of a talented learner proposed by Arancibia et al., (2008); Hartas et al., (2008); Hewston et al., (2005), and Skehan, (1998). Cognitive variables included tested: foreign language aptitude, verbal and non-verbal intelligence, learning styles, and learning strategies. The purpose of the research was to construct an extended cognitive profile of a 21-year-old student proficient in three languages. The research revealed that the subject is linguistically talented, especially in the area of phonological, analytical, and memory abilities. It is hypothesized that her superior abilities result from an extraordinarily efficient short-term phonological memory (Mackey et al., 2002). She uses miscellaneous learning strategies and her learning styles are versatile. The final conclusion is that research into linguistic talent is scarce, therefore further investigation, especially in the field of working memory of talented foreign language learners, is required.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2017-13":1,"unknown":2}},"corpusid":144611938,"openaccessinfo":{"externalids":{"MAG":"2074068799","ACL":null,"DOI":"10.2478\/V10057-009-0004-7","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The US Presidential Commission for the Study of Bioethical Issues has released its report on the study of the effectiveness of antibiotics in Guatemala in the 1940s and 1950s in which about 1300 people were deliberately infected with sexually transmitted diseases.\n\nPresident Barack Obama, the secretary of health and human services, Kathleen Sebelius, and the secretary of state, Hillary Clinton, apologised to the president of Guatemala after the experiments were discovered last year by Susan Reverby, an historian at Wellesley College, Massachusetts ( BMJ 2010;341:c5494, doi:10.1136\/bmj.c5494).\n\nThe Guatemala study's protocol was approved by the US attorney general, the US surgeon general, military medical officials, and an array of high ranking doctors and medical school experts. However, the investigators marked \u2026","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":28928321,"openaccessinfo":{"externalids":{"MAG":"1976334592","ACL":null,"DOI":"10.1136\/bmj.d5994","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This work demonstrates the use of an in\u2010capillary procedure for derivatization of amino acids, peptides, and alkylamines by anhydrides using capillary electrophoresis (CE). Migrating in an uncoated fused\u2010silica capillary, plugs of substrate and anhydride are injected separately and electrophoresed. Differential transport velocities permit the separate zones to penetrate each other under an applied field, thereby facilitating reaction. In initial experiments the extent of reaction between tryptophan and acetic anhydride was examined and product amounts quantitated by CE. In separate experiments a series of amino acids and peptides were injected into the capillary and reacted with phthalic anhydride on\u2010column to yield the phthalic derivatized species. Finally, on\u2010column derivatization of alkylamines with phthalic anhydride was investigated and electrophoretic mobility related to molecular weight of the derivatized amines. These procedures illustrate the use of the capillary as a microreactor in the facile synthesis of derivatized molecules and ease of quantitation of reaction products under conditions of electrophoresis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24972245,"openaccessinfo":{"externalids":{"MAG":"2094514920","ACL":null,"DOI":"10.1002\/1522-2683(20000901)21:15<3305::AID-ELPS3305>3.0.CO;2-1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two cases of necrotizing fasciitis in intravenous cocaine abusers are presented to alert the medical community to the possibility of these severe infections in such addicts. Antimicrobial therapy should include agents effective against Bacteroides species, streptococci, and Gram-negative aerobes; therapy directed only against staphylococci and Gram-negative aerobes is not sufficient.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32062961,"openaccessinfo":{"externalids":{"MAG":"2039761870","ACL":null,"DOI":"10.1001\/ARCHINTE.1982.00340160214036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Deprotonation of the 2-amino- 1,3-dimethylimidazolium salt 5 (obtained through methylation of 2-amino-l-methylimidazole (4)) by KH gives 2-imino-1,3-dimethylimidazoline 6. The trimethylsilylimino compound 14 is formed on the reaction of 6 with chlorotrimethylsilane in the ratio 2:1. Further reaction with chlorotrimethylsilane gives the silylated aminoimidazolium salt 15. The X-ray structures of 5 and 6 are reported.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":102043867,"openaccessinfo":{"externalids":{"MAG":"2335433690","ACL":null,"DOI":"10.1515\/znb-1995-1202","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znb-1995-1202\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A rain compensation algorithm (RCA) has been developed for use in the advanced communications technology satellite (ACTS) mobile terminal (AMT) system. The basic goal of the RCA is to control the transmitted data rates (9.6, 4.8 or 2.4 kbps) in the forward and return links so that a 3 dB link margin is maintained at the highest possible transmitted data rate. In this paper, analyses of both theoretical and practical issues relating to the RCA are presented. In addition, sample simulations of a one-dimensional version of the RCA at the MT are presented which illustrate typical RCA performance using both simulated and recorded pilot fade field data. It is found that with suitable post-processing, the RCA can provide reasonable (conservative) data rate estimates without making excessive data rate changes, i.e., data rate change fluctuations. It is anticipated that the results presented here will not only be useful for the eventual operation of the RCA, but more generally will be useful in the design and operation of other rain compensation techniques for K\/Ka-band communication systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":109539543,"openaccessinfo":{"externalids":{"MAG":"2021477712","ACL":null,"DOI":"10.1002\/(SICI)1099-1247(199605)14:3<297::AID-SAT537>3.0.CO;2-G","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Platelets not only have hemostatic function, but can also directly or indirectly recognize pathogenic microorganisms and the signals they produce to capture and destroy them through membrane receptors. They can collaborate with various components of the body's immune system by releasing of intraplatelet particulate matter, cytokines and chemokines to perform bactericidal functions. And it can also play a bactericidal role by swallowing pathogens, releasing antimicrobial proteins and chemokines and activating and enhancing other specialized anti-inflammatory cells bactericidal effect, such as leukocytes and so on. However, the bacteriostatic composition and bacteriostatic mechanism of platelets remain unclear, so attention should be paid to the immune mechanism and bacteriostatic effect of platelets.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262085003,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SETTING\nParenchymal lung destruction accompanied by active tuberculosis is, at least in part, caused by host as well as bacillus metalloproteinases. Mycobacterium tuberculosis has been shown to stimulate MMP-9 expression in the lung of infected organisms.\n\n\nDESIGN\nWe have used quantitative zymography and computer-assisted image analysis to measure the levels of type IV collagenases in 20 serum samples of patients with active tuberculosis and in 23 serum samples of healthy volunteers.\n\n\nRESULTS\nMean levels of the serum MMP-9 were over three-fold higher in tuberculous samples compared with normal serum (P < 0.0001), whereas the MMP-2 levels did not differ in these two groups. The levels of MMP-9 were significantly higher in subjects with advanced disease than in those with only limited disease changes (P < 0.05).\n\n\nCONCLUSIONS\nWe suppose that the elevation of serum MMP-9 levels in patients with tuberculosis is affected by the augmentation of synthesis and\/or secretion of this enzyme by inflammatory cells in response to M. tuberculosis infection. The observed association between the serum MMP-9 level and the extent of radiological change suggests that the quantification of the serum level of this enzyme may constitute a supplementary test in pulmonary tuberculosis diagnostics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27572348,"openaccessinfo":{"externalids":{"MAG":"2400050383","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study investigates the social factors responsible for street traders and buyers' disobedience to the Lagos State Street Traders and Illegal Market Law, 2003 (as amended 2017) despite the imposition of N90,000 and a jail term of 6 months on offenders. The study adopted a mixed method of social research using a total sample of 894 traders and 300 buyers surveyed across the three Senatorial Districts of Lagos (Lagos Central, Lagos West and Lagos East). The study population was randomly selected using multistage sampling technique. It also adopted Key informant interview, in-depth interview with participant observation method to explore the attitudes and narratives of the street traders and buyers about the enforcement of the law. Data obtained from the study using correlation and regression analytical techniques indicated that poverty (P=0.000), unemployment (P=0.008), household welfare (P=0.020), need to further education (P=0.035), need to rent a shop (P=0.037) and remittance (P=0.000) were key predictors of street traders' disobedience of the street trading law. The study also found that educated buyers disobeyed the law more than those with little or no education. It unveiled that, deviance by traders were prominent in the daytime and in urban centres than in the rural areas and night periods. Based on the findings, the article suggests a review of the street law in a way that accommodates the diverse interests in the informal sector","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259062932,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.36108\/ijs\/1202.21.0150","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Due to the advancement of malware which gains privileges to the operating system and drops a malicious code, and allowing unauthorized access to the target computer networks. One of this malware includes a Trojan horse which has access to computer or network with the aid of a user, whether knowingly or unknowingly. This paper presents a frame work of detecting a Trojan horse in network environment (client\/server) so as to tackle present kind of Trojan horses (BINGHE). The result of the experiment shows a great potential of the method in allowing the detection and analysing different behaviour and attack of Trojan horse malware in computer and client\/server network.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":53959703,"openaccessinfo":{"externalids":{"MAG":"2552811568","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"AIM\nDiabetics with coronary artery disease face a high risk of adverse events following coronary revascularization. However, recurrence rates of after the first revascularization have never been appraised. The aim of this study was to evaluate recurrent events in diabetics undergoing percutaneous coronary intervention (PCI) in the current era.\n\n\nMETHODS\nAuthors collected baseline and outcome data of consecutive type-2 diabetics treated with PCI (July 2002-December 2005) . End-points of interest were the long-term rates of major adverse cardiac events (MACE: cardiac death, myocardial infarction [MI], percutaneous target vessel revascularization [TVR-PCI], or coronary artery bypass grafting [CABG]), non-TVR PCI, and stent thrombosis.\n\n\nRESULTS\nA total of 429 diabetics were included, 191 (44%) insulin-dependent, with drug-eluting stents implanted in 232 (54%). After a median of 38 months, events were as follows: MACE in 167 (38.9%) subjects, cardiac death in 38 (8.8%), MI in 42 (9.8%), TVR-PCI in 130 (30.3%), CABG in 11 (2.6%), non-TVR-PCI in 52 (12.1%), and definite stent thrombosis in 9 (2.1%). Among the 129 patients undergoing TVR-PCI as first event, as many as 28 (21.7%) underwent a second TVR-PCI, 7 (5.4%) underwent a third TVR-PCI, and a further 2 (1.5%) underwent a fourth TVR-PCI, whereas CABG was performed in 2 (1.5%) and non-TVR-PCI in 4 (3.1%).\n\n\nCONCLUSIONS\nThis work, originally reporting on the risk of recurrent repeat revascularization events among diabetics treated with PCI, showed that adverse events occur frequently in these patients, but can be managed in most cases safely and successfully by means of repeat PCI only.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2188426,"openaccessinfo":{"externalids":{"MAG":"2461322157","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Passive-protection structures, against snow avalanches, are designed with rough estimates of the drag coefficient, depending straightforwardly on the obstacle's geometry. In this paper, assuming an avalanche as a dry granular flow, a numerical model is presented for studying the influence on the drag coefficient of both the shape and size of an obstacle impacted by a granular flow. Smallscale laboratory experiments were conducted to validate the numerical model. During the experiments, velocity profiles were estimated using the particle image velocimetry method applied to the pictures recorded by a fast camera, which focused perpendicular to the lateral wall. Flow thickness variations along the slope were estimated by post-processing the images recorded by another fast camera, which films a laser line projected on the free surface flow. From the lateral motion of that line, the thickness could be determined. The granular impact force was measured through an instrumented obstacle positioned at the lower end of a canal. A 3D numerical model, based on the discrete element method using the YADE code, was set up to reproduce the experimental configuration. The law of contact between discrete elements involved elastic components (normal and tangential stiffnesses) and dissipative components (a normal restitution coefficient and a friction coefficient based on the Coulomb friction law). The model was validated by comparisons with both the experimental flow characteristics (velocity profiles and thicknesses) and the impact load history. Once validated, the numerical model was used to investigate the contribution of the height and c \u00a92009 IOP Publishing Ltd and SISSA 1742-5468\/09\/P06012+14$30.00 .S tt.M ech. (209) P 0012 Predicting the drag coefficient of a granular flow using the discrete element method shape of the obstacle to the drag coefficient. Finally, results are discussed and compared with ones from other studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39294545,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Quartz sediments from the floor deposit at Jinmium Rock Shelter have been investigated using the multiple-grain and single-grain optical dating methods described by Galbraith et al. (1999, this volume). Here we present the results of this dating programme and argue that the artefact-bearing sediments were deposited within the last 10 000 years. This time interval is consistent with the radiocarbon chronology but is much younger than previous claims for initial human occupation during the Pleistocene. Analysis of individual grains revealed also that the characteristic saturation doses of some grains are unusually high, which may permit dating of deposits older than a few hundred thousand years. Such grain-to-grain differences raise doubts, however, about the validity of using multiple-grain samples to investigate the phenomenology of quartz luminescence.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129460920,"openaccessinfo":{"externalids":{"MAG":"2113863927","ACL":null,"DOI":"10.1111\/J.1475-4754.1999.TB00988.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cetaceans in the Southern California Bight (SCB) are exposed to high levels of halogenated organic contaminants (HOCs), which have previously been linked to impaired reproductive health and immune responses. We used a combination of molecular tools to examine the potential physiological impacts of HOC exposure in two bottlenose dolphin ( Tursiops truncatus) ecotypes in the SCB. We quantified 25 HOCs in the blubber of 22 biopsies collected from males between 2012 and 2016. We then analyzed genome-wide gene expression in skin using RNA-sequencing and measured blubber testosterone to compare HOC exposure with cellular and endocrine biomarkers. We found high levels of HOCs in both ecotypes with significantly higher total polychlorinated biphenyls\u00a0(PCBs), polybrominated diphenyl ethers (PBDEs), tris(4-chlorophenyl)methanol\u00a0(TCPMOH), and chlordane-related compounds in the coastal ecotype versus the offshore ecotype. We found evidence of PBDE bioaccumulation in both ecotypes, however, the pattern of bioaccumulation or endocrine disruption for other HOCs was different between the ecotypes, suggesting potential endocrine disruption in the coastal ecotype. We also observed correlations between HOCs and gene coexpression networks enriched for xenobiotic metabolism, hormone metabolism, and immune response that could indicate cellular effects from HOC exposure. By integrating measurements of HOC load with both transcriptome profiling and endocrine biomarkers, our approach provides insight into HOC exposure and potential impacts on wild cetacean health in southern California.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73725266,"openaccessinfo":{"externalids":{"MAG":"2920883824","ACL":null,"DOI":"10.1021\/acs.est.8b06487","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"being absorbed into the mainstream economy. In both cases surplus is converted into social status through the destruction of luxury goods. The film suffers, in part, from far too many shots of people in the streets wearing logos. The women shopping for handbags also become tedious after a while. However, aside from these points, it is an entertaining and provocative tour of some of the main issues raised by luxury branded goods in a global economy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":192251531,"openaccessinfo":{"externalids":{"MAG":"2538362455","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Organic donor\u2013acceptor dyes, formed by a high-yielding [2 + 2] cycloaddition\u2013retroelectrocyclisation process between aniline-substituted alkynes and tetracyanoethylene (TCNE) or 7,7,8,8-tetracyanoquinodimethane (TCNQ), were employed as novel photosensitizers without carboxylic acid anchoring groups in dye-sensitized solar cells (DSSCs). The efficient adsorption of the donor\u2013acceptor dyes onto TiO2 was confirmed by UV-vis and IR spectroscopies. The photovoltaic performances of the DSSCs suggested that the triphenylamine derivatives 3 and 4 provide higher current densities (Jsc) as compared to the corresponding dimethylaniline counter molecules 1 and 2. This was mainly due to the excellent charge-separation efficiencies and lower charge-recombination rates of the triphenylamine moieties. It was also found that the devices sensitized by the TCNQ-adducted dyes 2 and 4 display open-circuit voltages (Voc) higher than those of the TCNE-adducted counter dyes 1 and 3. All these results were reasonably explained by the J\u2013V curve fitting based on the equivalent-circuit model as well as the comparison between the absorption and incident-photon-to-current-conversion efficiency (IPCE) spectra.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":94800968,"openaccessinfo":{"externalids":{"MAG":"2002846230","ACL":null,"DOI":"10.1039\/C3TC32165G","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Properties of the binding mechanism in associative recognition were studied by examining the influence of the pictorial superiority effect on the age-related associative deficit. The informative aspect of associative recognition is the recollection of the pairing. Previous findings indicate that recollection is susceptible to aging and that pictorial presentation can enhance recollection and facilitate associative recognition. Pictorial presentation was found to facilitate item recognition by both young and older adults, associative recognition by young adults, but not associative recognition by older adults. Our findings support the hypothesis that the binding mechanism in associative recognition is content independent. Theoretical implications are discussed.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":8423040,"openaccessinfo":{"externalids":{"MAG":"2419108225","ACL":null,"DOI":"10.1037\/pag0000069","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Blockchain-based systems have gained immense popularity as enablers of independent asset transfers and smart contract functionality. They have also, since as early as the first Bitcoin blocks, been used for storing arbitrary contents such as texts and images. On-chain data storage functionality is useful for a variety of legitimate use cases. It does, however, also pose a systematic risk. If abused, for example by posting illegal contents on a public blockchain, data storage functionality can lead to legal consequences for operators and users that need to store and distribute the blockchain, thereby threatening the operational availability of entire blockchain ecosystems. In this paper, we develop and apply a cloud-based approach for quickly discovering and classifying content on public blockchains. Our method can be adapted to different blockchain systems and offers insights into content-related usage patterns and potential cases of abuse. We apply our method on the two most prominent public blockchain systems\u2014Bitcoin and Ethereum\u2014and discuss our results. To the best of our knowledge, the presented study is the first to systematically analyze non-financial content stored on the Ethereum blockchain and the first to present a side-by-side comparison between different blockchains in terms of the quality and quantity of stored data.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1,"unknown":2}},"corpusid":247518936,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1145\/3487553.3524628","PubMedCentral":null,"ArXiv":"2203.09379"},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3487553.3524628","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background: Cancer-related information is a major need among cancer patients. Existing data indicate that cancer patients who are anxious or depressed have poorer treatment outcomes. Aim: The aim of this study is to assess the association between psychological distress and unmet information needs among female cancer patients in two teaching hospitals in Southwest Nigeria. Materials and Methods: Using a descriptive-correlational design, 244 females in the oncology units of two selected Nigerian teaching hospitals were purposively selected to complete a modified psychological distress scale and a self-developed information need questionnaire. Data were analyzed using descriptive and inferential statistics P value set at 0.05. Results: Majority (76%) of the patients were psychologically distressed, 71.3% of the participants wanted specific information on their cancer disease. There is a correlation between cancer patients' level of psychological distress and their unmet information needs (P = 0.027; r = \u22120.142) and a correlation between cancer patients' information needs and duration of their illness (P = 0.034; r = \u22120.135). Conclusion: Cancer patients experience psychological distress to some extent. Furthermore, they are interested in finding out information about their cancer disease. Every unmet information needs impact on the psychological distress experienced by patients. It is, therefore, recommended that nurses and other healthcare professionals should endeavor to assess the specific information needs to provide required information and ease their psychological distress.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":79926590,"openaccessinfo":{"externalids":{"MAG":"2782960617","ACL":null,"DOI":"10.4103\/cjhr.cjhr_62_17","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/cjhr.cjhr_62_17","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This work investigated the use of LyP-1 as a homing peptide for p32 receptor targeting on the surface of an endostatin (ENT)-loaded chitosan-grafted nanosystem intended for intracellular delivery of ENT and mitochondrial targeting in a squamous cell carcinoma (SCC) cell line (KYSE-30) model. The angiogenic factors for VEGF-C and MMP2 were assessed with in vivo evaluation of the nanosystem upon ENT release and tumor necrosis in nude mice with a KYSE-30 cell xenograft. The LyP-1-modified nanosystem revealed a three-fold decrease in proliferation at 1000 \u00b5g\/mL compared with the control and facilitated receptor-mediated cellular uptake and internalization. In addition, targeting of the Lyp-1-functionalized nanosystem to mitochondrial and nuclear proteins in vitro and in vivo was achieved. Up to 60% inhibition of KYSE-30 cell migration was observed and the expressions of VEGF-C and MMP-2 as angiogenic markers were reduced 3- and 2-fold, respectively. A marked reduction in tumor mass was recorded (43.25%) with the control, a 41.36% decrease with the nanoparticles and a 61.01% reduction with the LyP-1-modified nanosystem following treatment in mice. The LyP-1-functionalized nanosystem targeted tumor lymphatics, instigated nuclear rupture and mitochondrial distortion, and decreased cell proliferation and migration with inhibition of VEGF-C and MMP2 expression.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247494553,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ph15030353","PubMedCentral":"8955112","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1424-8247\/15\/3\/353\/pdf?version=1647330613","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Treatment results of 54 patients with liver cirrhosis and portal hypertension, complicated by diuretic-resistant ascites, were analyzed. Peritoneal port-system was implanted in 12 cases, the rest 42 patients had peritoneovenous bypass with the use of Levine's valve. Port-system implantation was possible in patients with contraindications for bypass, such as low central venous and intraabdominal pressure gradient, chylous ascites, ventral hernias etc. The use of peritoneal ports provides fractional reinfusion af the ascetic fluid, which excludes such complications as hemodilution and coagulopathy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20893381,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A computational model of a low-pressure discharge having a negative-ion component is developed. Many existing models for this type of discharge consider collisionless positive ions and two negative species each obeying Boltzmann relations. Our aim is to relax the Boltzmann-negative-ion assumption and we use a more realistic model with kinetic positive ions, kinetic negative ions and Boltzmann electrons. Positive and negative ions are created uniformly in the discharge at a constant rate, and lost either to the walls or via volume recombination. This model is solved using a hybrid simulation with particle-in-cell (PIC) ions. The negative-ion distribution function is found to have cold and hot components of nearly equal densities for which Te\/T-cold\u2248100 (the creation temperature) and Te\/T-hot\u22485-20. The computed positive ion flux exiting the discharge agrees approximately with those calculated from Boltzmann-negative-ion models when the negative-ion temperature is accounted for correctly. It has been predicted that three electronegative discharge structures can exist: uniform, stratified and double-layer stratified. All three structures are observed in our model. In particular, a double-layer stratified discharge is observed when the effective negative-ion temperature is sufficiently low, in qualitative agreement with Boltzmann-negative-ion models.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250747526,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/33\/15\/315","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This research examines the employing of a Play Curricular Activity Reflection Discussion (PCaRD) and Digital Game-based (DGB) through flipped learning on the EFL learners' grammar skills to improve their achievement and attitudes. The participants were 66 EFL female intermediate students in Iran; the research was conducted over 10 weeks. A PCaRD DGB flipped learning was used for the experimental group (N = 33), and a standard flipped classroom was used for the control group (N = 33). Both groups constructed using the same teacher, time, coursebook, and videos. The PCaRD DGB flipped learning provided mobile-based game apps and a game-based feedback mechanism in the form of collaborative response and created a setting in which learners could engage in more grammar activity, pay more attention to their answers, and improving their grammar skills. The results indicated that the PCaRD DGB flipped learning outperformed the standard flipped learning in grammar achievement and in terms of their positive attitudes. The researcher speculates that the PCaRD DGB flipped learning strengthens EFL learners' grammar skills and a positive attitude.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238839688,"openaccessinfo":{"externalids":{"MAG":"3185675129","ACL":null,"DOI":"10.18823\/asiatefl.2021.18.2.10.544","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.asiatefl.org\/main\/download_pdf.php?i=949&c=1626228409&fn=18_2_10.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Hepatitis C virus (HCV) E2-CD81 binding dampens protective immune response. We have identified that an alteration of amino acids in the front layer of soluble E2 (sE2) disrupts CD81 interaction and alters the cytokine response. ABSTRACT Hepatitis C virus (HCV) is characterized by a high number of chronic cases owing to an impairment of innate and adaptive immune responses. CD81 on the cell surface facilitates HCV entry by interacting with the E2 envelope glycoprotein. In addition, CD81\/E2 binding on immunity-related cells may also influence host response outcome to HCV infection. Here, we performed site-specific amino acid substitution in the front layer of E2 sequence to reduce CD81 binding and evaluate the potential of the resulting immunogen as an HCV vaccine candidate. The modified sE2 protein (F442NYT), unlike unmodified sE2, exhibited a significant reduction in CD81 binding, induced higher levels of proinflammatory cytokines, repressed anti-inflammatory response in primary monocyte-derived macrophages as antigen-presenting cells, and stimulated CD4+ T cell proliferation. Immunization of BALB\/c mice with an E1\/sE2F442NYT nucleoside-modified mRNA-lipid nanoparticle (mRNA-LNP) vaccine resulted in improved IgG1-to-IgG2a isotype switching, an increase in neutralizing antibodies against HCV pseudotype virus, a B and T cell proliferative response to antigens, and improved protection against infection with a surrogate recombinant vaccinia virus-expressing HCV E1-E2-NS2aa134-966 challenge model compared to E1\/unmodified sE2 mRNA-LNP vaccine. Further investigation of the modified E2 antigen may provide helpful information for HCV vaccine development. IMPORTANCE Hepatitis C virus (HCV) E2-CD81 binding dampens protective immune response. We have identified that an alteration of amino acids in the front layer of soluble E2 (sE2) disrupts CD81 interaction and alters the cytokine response. Immunization with modified sE2F442NYT (includes an added potential N-linked glycosylation site and reduces CD81 binding activity)-mRNA-LNP candidate vaccine generates improved proinflammatory response and protective efficacy against a surrogate HCV vaccinia challenge model in mice. The results clearly suggested that HCV E2 exhibits immunoregulatory activity that inhibits induction of robust protective immune responses. Selection of engineered E2 antigen in an mRNA-LNP platform amenable to nucleic acid sequence alterations may open a novel approach for multigenotype HCV vaccine development.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249045882,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1128\/jvi.00523-22","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9215226","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This research is a quasi-experimental research with a quantitative descriptive research approach, which aims to: (1) To determine the difference in the results of Practicum Learning conducted online with direct practicum in the APP Laboratory at D3 LLU XII cadets of Aviation Polytechnic Surabaya (2) To determine the effect of distance learning Aproach and Area Control Procedures for the motivation and learning outcomes of D3 LLU XII cadets of Aviation Polytechnic Surabaya (3) To find out the causal relationship between practical teaching methods in the laboratory and online practicums on the learning outcomes of D3 LLU XII cadets.The results obtained are that there is an influence of the distance learning method on the cadets' learning outcomes in the Approach Control Procedural course which includes planning, implementation, results and evaluation. The conclusions of this study are (1) LLU XII cadets in the planning and preparing category have a high average, namely in the category of determining the preparation of learning to be used, the percentage is 73% and the category feels they have the responsibility to attend learning, the percentage is 54%, (2 ) LLU XII cadets in the implementation category have a high average, namely in the category of implementing strategies in exercise according to each learning style, the percentage is 57% and the habit category for supporting and overcoming problems in learning gets a percentage of 60% (3) LLU XII cadets in the Outcomes and Evaluation categories, the average percentage is high, namely in the Habits After Finishing Learning category, a high percentage of 67% is obtained and the self-evaluation category for learning outcomes has a balanced percentage in the high and medium categories, namely 50% versus 50%.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":261410031,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.46491\/jp.v8i2.1500","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/ejournal.poltekbangsby.ac.id\/index.php\/jurnalpenelitian\/article\/download\/1500\/1468","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"AIM\nTo establish and validate a simple quantitative assessment method for nonalcoholic fatty liver disease (NAFLD) based on a combination of the ultrasound hepatic\/renal ratio and hepatic attenuation rate.\n\n\nMETHODS\nA total of 170 subjects were enrolled in this study. All subjects were examined by ultrasound and (1)H-magnetic resonance spectroscopy ((1)H-MRS) on the same day. The ultrasound hepatic\/renal echo-intensity ratio and ultrasound hepatic echo-intensity attenuation rate were obtained from ordinary ultrasound images using the MATLAB program.\n\n\nRESULTS\nCorrelation analysis revealed that the ultrasound hepatic\/renal ratio and hepatic echo-intensity attenuation rate were significantly correlated with (1)H-MRS liver fat content (ultrasound hepatic\/renal ratio: r = 0.952, P = 0.000; hepatic echo-intensity attenuation r = 0.850, P = 0.000). The equation for predicting liver fat content by ultrasound (quantitative ultrasound model) is: liver fat content (%) = 61.519 \u00d7 ultrasound hepatic\/renal ratio + 167.701 \u00d7 hepatic echo-intensity attenuation rate -26.736. Spearman correlation analysis revealed that the liver fat content ratio of the quantitative ultrasound model was positively correlated with serum alanine aminotransferase, aspartate aminotransferase, and triglyceride, but negatively correlated with high density lipoprotein cholesterol. Receiver operating characteristic curve analysis revealed that the optimal point for diagnosing fatty liver was 9.15% in the quantitative ultrasound model. Furthermore, in the quantitative ultrasound model, fatty liver diagnostic sensitivity and specificity were 94.7% and 100.0%, respectively, showing that the quantitative ultrasound model was better than conventional ultrasound methods or the combined ultrasound hepatic\/renal ratio and hepatic echo-intensity attenuation rate. If the (1)H-MRS liver fat content had a value < 15%, the sensitivity and specificity of the ultrasound quantitative model would be 81.4% and 100%, which still shows that using the model is better than the other methods.\n\n\nCONCLUSION\nThe quantitative ultrasound model is a simple, low-cost, and sensitive tool that can accurately assess hepatic fat content in clinical practice. It provides an easy and effective parameter for the early diagnosis of mild hepatic steatosis and evaluation of the efficacy of NAFLD treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22205223,"openaccessinfo":{"externalids":{"MAG":"2288845062","ACL":null,"DOI":"10.3748\/wjg.v20.i47.17985","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.3748\/wjg.v20.i47.17985","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Besides the known compounds longistylines C (1), D (2), and 3,5-dimethoxystilbene (5), five new prenylated stilbenes, named chiricanines A--E (3, 4, 6--8), have been isolated from the root bark of Lonchocarpus chiricanus. Their structures were resolved on the basis of spectrometric methods including (1)H, (13)C, and 2D NMR experiments and mass spectrometry. Compound 3 was the only prenylated stilbene to demonstrate antifungal effects against Cladosporium cucumerinum. Four of the isolated compounds showed toxic properties against larvae of the yellow fever-transmitting mosquito Aedes aegypti. Compound 5 was found to be as potent as rotenone in larvicidal dilution tests.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39216101,"openaccessinfo":{"externalids":{"MAG":"1970521142","ACL":null,"DOI":"10.1021\/NP000597W","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nThe role of mass participation sports events in encouraging regular physical activity is under-researched. This study explored the public health potential of parkrun, a UK-wide network of free weekly timed 5-km runs in public parks.\n\n\nMETHODS\nA total of 7308 adult participants of parkrun self-reported demographic characteristics, current physical activity and the perceived impact of involvement. Objective data on attendance and 5-km performance were available from the central parkrun database.\n\n\nRESULTS\nAt registration 25.3% of participants described themselves as non-runners, with this group including the highest proportions of females (53.8 versus 48.9% for the total sample), overweight\/obese (45.2 versus 33.2%) and those with a limiting disability (6.1 versus 4.3%). The initial non-runners had the largest increase in 5-km performance (15.8 versus 10.2%), and were more likely to report health-related benefits. More regular attendance was positively associated with perceived benefits. Middle-aged and older adults were well represented overall (60.9 and 14.3% of the sample, respectively).\n\n\nCONCLUSIONS\nPreliminary evidence suggests that parkrun is attractive to non-runners, with women, older adults and overweight people well represented. The observed fitness improvements and perceived benefits indicate the scope for investigating the effectiveness of parkrun as a cost-effective community-based intervention for improving public health.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2191116,"openaccessinfo":{"externalids":{"MAG":"2132828477","ACL":null,"DOI":"10.1093\/pubmed\/fdt082","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/jpubhealth\/article-pdf\/36\/2\/268\/4424930\/fdt082.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a dynamic channel assignment (DCA) scheme for distributed antenna networks (DANs). DANs, in which many antennas are distributed in each cell, significantly reduce the transmit power compared to conventional cellular networks (CNs). In DAN, a different group of channels should be assigned for each distributed antenna to avoid the interference. Since DAN can also reduce the interference power due to its low transmit power property, the same channel groups can be reused even within the same cell. Proposed DCA scheme dynamically assigns the channels based on the co-channel interference measurement. Computer simulation results demonstrate that the DAN using proposed DCA achieves higher spectrum efficiency than the conventional CN.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2014-10":1,"2015-11":1}},"corpusid":448825,"openaccessinfo":{"externalids":{"MAG":"2169890552","ACL":null,"DOI":"10.1109\/VETECS.2012.6240293","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Individual learners have different requirements and characteristics, and as a result learning content should be able to be personalized and adaptable to the e-learner' profile. Little research work undertaken to tackle this issue, and it has been limited to ad-hoc work on personalizing, and adapting learning content in e-Learning. This paper presents two methods for modeling user profile and for personalizing and adapting a given content to match that profile: inductive (without user intervention) and deductive (with user intervention). These methods will be used as a base to review and classify research work undertaken on personalizing content in the domain of knowledge management and e-learning systems. Based on these reviews, especially those undertaken in personalizing knowledge content in knowledge management systems, the paper proposes a comprehensive approach for personalizing learning content.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27327620,"openaccessinfo":{"externalids":{"MAG":"2066484564","ACL":null,"DOI":"10.1109\/ICELETE.2013.6644377","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bidens pilosa L. var minor (Blume) Sherff, B. pilosa L. and B. chilensis DC (compositae), commonly known as \"Ham-hong-chho\" in Taiwan, have been traditionally used for medicinal purposes. To clarify and compare the hepatoprotective effects of these three plants, we evaluated their potential effectiveness on CCl4- and acetaminophen-induced acute hepatic lesions in rats. The results indicated that the increase in SGOT and SGPT activities caused by CCl4 (3.0 ml\/kg, s.c.) and acetaminophen administration (600 mg\/kg, i.p.) could be significantly reduced by treating with the extracts of all the three kinds of \"Ham-hong-chho\" and the extract of B. chilensis exhibited the greatest hepatoprotective effects. These phenomena were also confirmed by histological observation. Liver damage induced by CCl4 and acetaminophen was markedly improved in the extract of B. chilensis treated groups, while groups treated with the extracts of B. pilosa var minor and B. pilosa demonstrated only moderate protective effects. The pharmacological and pathological effects of these three crude groups were compared with Bupleurum chinense, which has been reported previously as a treatment criteria in the CCl4 model, and with silymarin as a standard reference medicine in the acetaminophen model. The results suggest that B. pilosa var minor, B. pilosa and B. chilensis can protect liver injuries from various hepatotoxins and have potential as broad spectrum antihepatic agents.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22427894,"openaccessinfo":{"externalids":{"MAG":"2143830419","ACL":null,"DOI":"10.1142\/S0192415X96000293","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrical energy supply interruption degrades reliability of power supply as well as social costs and economic loss. It is important to assess the reliability of the power system. Nowadays IEC61850 based substation automation system(SAS) has been developed for an updating of automation and interoperability. In this study, three kinds of reliability block diagram(RBD) were proposed to examine of network availability of the three types SAS. And reliability and unreliability of the SAS was formulated using the RBD. Finally, while varying the value of reliability and unreliability, the reliability and the unreliability of the overall system were evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":111820277,"openaccessinfo":{"externalids":{"MAG":"2309550549","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of the study was to investigate the effectiveness of ICT training workshop of tutors of Allama Iqbal Open University Pakistan. The study was delimited to tutors of Multan region. The total sample comprised of 100 tutors. All the tutors who participated in ICT training workshop in Multan region were taken as sample in the study. A questionnaire having two parts, based on five point rating scale was developed by the researcher. Part one was about the competency level of computer skills while Part two was based on items related to training delivery, structure and content. Part One of questionnaire had five levels of competency about computer skills. The questionnaire was personally administered and collected back by the researcher himself on the last day of workshop. The collected data were analyzed by using descriptive statistics. Through this study it was found that majority of the tutors strongly agreed that training enhanced their computer skills. Majority of the respondents consider themselves to be generally competent in the use of computer. They also agreed that there was appropriate infrastructure and technical support in lab during training workshop. Moreover, it was found that the training imparted the knowledge of pedagogy of using computers for distance education. Keywords\u2014ICT, Tutors, AIOU.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":110802421,"openaccessinfo":{"externalids":{"MAG":"2186033604","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The complete mitochondrial genome of Ompok bimaculatus was obtained, using illumina high-throughput NextSeq 500 with 2\u2009\u00d7\u2009150\u2009bp sequencing of mitochondrial DNA. The genome of O. bimaculatus was 16,482\u2009bp in length (GenBank Accession No. KY887474) comprised of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and a control region i.e. D-loop. In present mitogenome, 9 SSR were identified and validated in silico and secondary structures of all the 22 tRNA were predicted. The arrangement of genes was found identical to other siluriformes fish mitogenomes available in NCBI database. Phylogenetic relationship with closely related species were established which provide useful insights into taxonomic status of the species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":89683492,"openaccessinfo":{"externalids":{"MAG":"2619237648","ACL":null,"DOI":"10.1080\/23802359.2017.1334520","PubMedCentral":"7799613","ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23802359.2017.1334520?needAccess=true","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Seismic response of a high-rise building under rare earthquake is numerically investigated in the paper. The Height of the building is 266m, which goes beyond the limit of 150m in Chinese standard, so nonlinear analysis should be performed to investigate its elasto-plastic behaviors under severe earthquake excitations. In the finite-element model for analysis, beam-column members of the structure are simulated by beam elements, while the core tube is simulated by shell elements. The concrete damage plasticity model is used for concrete members, while the kinematic hardening rule is defined for steel beam-column members. Four sets of earthquake wave, including 3 sets of strong earthquake records and 1 set of artificial wave, are adopted in the analysis. The analysis results show that, under severe earthquakes, steel frame members and steel truss members in the strengthened floors keep elastic. Severe damages are detected in almost all coupling beams in the core tube, as well as shear-walls near strengthened stories, where lateral stiffness would decrease seriously. Through the investigation, it is also found that the largest story drift is less than the maximum allowable value in the Chinese code for seismic design of buildings. So it is concluded that the high-rise building will not collapse when the place is subjected to severe earthquakes. Besides, some design suggestions are proposed according to nonlinear dynamic analysis in the paper.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":108453130,"openaccessinfo":{"externalids":{"MAG":"1998811424","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMR.378-379.292","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Ochratoxin A (OA) and Aflatoxin B1 (AFB1), the food borne mycotoxins are produced by several fungal species of the genera Aspergillus and Penicillium. To determine the teratogenic effects, these mycotoxins were administered orally either individually or in combination to the pregnant Wistar rats on days 6-15 of gestation. OA and AFB1 were dissolved in corn oil and different doses of OA (0.125, 0.25, 0.50, and 0.75 mg\/kg), AFB1 (0.125, 0.25, 0.50, and 1.00 mg\/kg), and a combination of OA+AFB1 (0.125+0.125; 0.25+0.50; 0.50+0.25 mg\/kg) were given by gastric intubation to rats. During dosing period, the body weight and body weight gains significantly decreased at a higher dosage, in both individual and combined treatments. In all the combination treatments, the percent implants resorbed, fetal body weights, and crown-rump lengths were comparable to those of controls and with the individual mycotoxin treatment. The number of dead fetuses was significantly increased in the high OA combination (OA+AFB1 0.50+0.25) group as compared with the other two combinations. OA and AFB1 alone and in combination caused various gross, skeletal, and visceral anomalies. The occurrence was considerably less pronounced in fetuses of AFB1 and combination groups as compared with those of OA group fetuses. The exencephaly, incomplete closure of skull, wavy and fused ribs, agenesis of the ischium bone, and enlarged renal pelvis, recorded in OA treatment and ear abnormality and incomplete ossification of skull bones observed in AFB1 when given individually, were not seen in combination groups. However, new manifestations, such as gastroschisis and syndactyly were observed and the incidence of cardiac defects was increased in fetuses due to the combined treatment. The results of the present study indicated that there is some interaction between these mycotoxins that resulted in reduced teratogenic activity of OA in the presence of AFB1. Apparently, new manifestations observed in combination treatment points to the potential threat of teratogenicity in terms of public health hazards.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35673155,"openaccessinfo":{"externalids":{"MAG":"1974467304","ACL":null,"DOI":"10.1002\/BDRB.20021","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on the monthly averaged sea surface chlorophyll-a concentration data continuously for more than 17 years (Jul. 2002\u2013Dec. 2019), the analyzed results show that the averaged chlorophyll-a concentration in Khanh Hoa waters was 0.58 mg\/m 3 , and the monthly average variation was \u00b1 0.14 mg\/m 3 (that is equivalent to about \u00b1 24%). Under the impact of ENSO phenomena, in the years when the double La Ni\u00f1a events occurred (two consecutive years in the La Nina event occurs), the chlorophyll-a anomaly index fluctuated from -0.99 mg\/m 3 to 1.62 mg\/m 3 . These are very strong fluctuation levels, corresponding to the decrease or increase in chlorophyll-a concentration from 86% to 279%. In the El Ni\u00f1o years, the fluctuations of chlorophyll-a concentration were little affected unless the two previous years in which the double La Ni\u00f1a event occurred. These fluctuations have significantly impact nutritional resources and water quality because chlorophyll-a concentration is one of the key indices in studying the health status of any natural marine ecosystem. In addition, chlorophyll-a concentration in Khanh Hoa waters often varies between seasons. The averaged chlorophyll-a concentration reaches its maximum value in the winter, then decreases gradually in the spring and usually reaches the minimum value in the summer, then rises gradually again in the autumn.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":245633888,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \nThis chapter examines the relationship between news media in Cinema Novo films to underscore the impact of their shared discourse on the history of Brazilian films. \n \nThe author discusses the emplotment of news media within representative Cinema Novo films whose narratives speak to an ongoing debate concerning the role of print and televisual journalism in the increasingly repressive political environment of the military dictatorship installed in the 1960s. Interpretations on the level of film narrative, of specific scenes, and of shot and shot-sequencing contribute to the discussion, situated within the broader historical context of the established laws and commissions of 1960s Brazil. \n \nTogether, the analyzed films' various interventions in Brazilian cultural and political history offer a complex representational fabric simultaneously constituting and critiquing national discourse. \n \nThe present research is limited to films of the 1960s but has implications for the interpretation of many Brazilian films and for Brazilian film history writ large. The overlap of film and news media is abundantly evident in the films of the Retomada and New Millennial Brazilian Cinema, but they do not fit within the scope of this chapter. \n \nThis analysis discusses a major canonical film (Entranced Earth) alongside lesser-known films (Threatened City, Freedom of the Press). When considered together in the light of their shared reflections concerning news media, these films bring up previously underexamined issues within the respective fields of Communication Studies and Brazilian Film Studies.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":193787982,"openaccessinfo":{"externalids":{"MAG":"2620669435","ACL":null,"DOI":"10.1108\/S2050-206020170000013005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Scientists are retrieving data from the largest effort yet to monitor the Atlantic conveyor belt, a set of powerful ocean currents with far-reaching effects on the global climate that has mysteriously slowed over the past decade. Five research cruises this spring and summer will fetch data from the 53 moorings in an array called Overturning in the Subpolar North Atlantic Program (OSNAP), which stretches from Labrador to Greenland to Scotland. The array9s measurements of temperature, salinity, and current velocity will be key to understanding the Atlantic Meridional Overturning Circulation (AMOC), and how it is affected by climate change. The AMOC currents include the Gulf Stream, which brings shallow warm waters north, nourishing fisheries and warming northwest Europe. The warm waters give up their heat in the bitterly cold regions monitored by OSNAP, become denser, and sink, forming ocean-bottom currents that return southward, hugging the perimeter of the ocean basins. Models suggest that climate change should weaken the AMOC as warmer Arctic temperatures, combined with buoyant freshwater from Greenland9s melting ice cap, impede the formation of deep currents. But so far, limited ocean measurements show the AMOC to be far more capricious than the models have been able to capture.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":987646,"openaccessinfo":{"externalids":{"MAG":"2352847079","ACL":null,"DOI":"10.1126\/science.352.6287.751","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A microcomputer-based decision support system that determines and evaluates maintenance requirements of repairable item populations is developed. The model combines a multi-indenture maintenance tree concept with a nested Markov chain multistream concept to generate maintenance requirements for the total life cycle under steady-state as well as nonsteady-state conditions. The model meets the maintenance planning needs by providing spare parts requirements in the form of inventory levels, manpower hours required, the associated costs of the logistics system, and the availability of units for the proposed logistics. A case study is also presented.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-48":1,"2014-10":1,"unknown":2}},"corpusid":11299344,"openaccessinfo":{"externalids":{"MAG":"2071628298","ACL":null,"DOI":"10.1109\/TSMC.1987.4309062","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"&NA; The current study aims to evaluate, for the first time in the Portuguese population, the association with venous thromboembolism (VTE) of five well known and replicated VTE-associated single nucleotide polymorphisms (SNPs) in genes ABO, F11 and FGG. A population sample of 96 cases of VTE, without strong or moderate inherited or noninherited predisposing factors, and 148 healthy controls were analyzed for variants in genes ABO (rs2519093; rs8176719), F11 (rs2036914; rs2289252) and FGG (rs2066865). SNPs were genotyped by real-time PCR with TaqMan probes or by PCR\u2013restriction fragment length polymorphism. Logistic regression, adjusted for age and sex, revealed nominal significant association between the ABO rs8176719 C-allele and VTE in the additive model [odds ratio (OR) 1.62; P\u200a=\u200a0.015] and significant association in the dominant model (OR 2.68; P\u200a=\u200a0.001). A nominal significant association with VTE was found for the FGG rs2066865 minor T-allele in the dominant model (OR 1.82; P\u200a=\u200a0.034). A genetic risk score created by using subjects who carry one or any combination of two to four risk alleles showed a cumulative effect on VTE: OR 2.31 (P\u200a=\u200a0.025) and OR 3.23 (P\u200a=\u200a0.0016), respectively, compared with individuals who have none of the risk alleles. Our data suggest that SNPs ABO rs8176719 and FGG rs2066865 may contribute individually to the VTE susceptibility in the Portuguese population. A genetic risk score combining the VTE-associated FGG and ABO alleles improved the risk prediction of VTE.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":51622386,"openaccessinfo":{"externalids":{"MAG":"2883152131","ACL":null,"DOI":"10.1097\/MBC.0000000000000753","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study proposes two models for exploring the lexical contents of Part One of the most popular Arabic as a Foreign Language textbook series, Al-Kitaab fii Ta'allum Al'Arabiyya. Through the lens of a word families framework, this study hypothesizes on the contents and arrangement of the L2 Arabic mental lexicon after completing the textbook. Through counting lexemes, lemmas, and word family members, it is possible to gain insight into the quantity of vocabulary items present within the textbook outside of traditional measures like the triconsonantal root. Through a frequency-based framework, this study analyzes textbook vocabulary items in light of the 5,000 most frequent lemmas in the language from a corpus of 30 million tokens from A Frequency Dictionary of Arabic (Buckwalter and Parkinson: 2011). A comparison between textbook vocabulary and frequency data points to the relationship between the vocabulary studied by AFL learners and the most widely used forms in the language as a whole. While this study gives special consideration to frequency data up to the 3,000 word level, the sheer amount of lexical knowledge necessary for reading Arabic newspapers and novels necessitates integration of frequency-derived data at even the novice level. A lexical and frequency-based approach to AFL instruction and curriculum design may prove helpful in decreasing the decidedly large vocabulary burden (Nation: 1990, cited in Young: 2011) for learners of Arabic as a Foreign Language.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":60121443,"openaccessinfo":{"externalids":{"MAG":"428270992","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We revisit the basic variational formulation of the minimization problem associated with the micromagnetic energy, with an emphasis on the treatment of the stray field contribution to the energy, which is intrinsically non-local. Under minimal assumptions, we establish three distinct variational principles for the stray field energy: a minimax principle involving magnetic scalar potential and two minimization principles involving magnetic vector potential. We then apply our formulations to the dimension reduction problem for thin ferromagnetic shells of arbitrary shapes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":152283006,"openaccessinfo":{"externalids":{"MAG":"2944133814","ACL":null,"DOI":"10.1137\/19M1261365","PubMedCentral":null,"ArXiv":"1905.04568"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Shock ignition concept is a promising approach to inertial confinement fusion that may allow obtaining high fusion energy gains with the existing laser technology. However, the spike driving laser intensities in the range of 1-10\u00a0PW\/cm2 produces the energetic electrons that may have a significant effect on the target performance. The hybrid numerical simulations including a radiation hydrodynamic code coupled to a rapid Fokker-Planck module are used to asses the role of hot electrons in the shock generation and the target preheat in the time scale of 100\u00a0ps and spatial scale of 100\u00a0\u03bcm. It is shown that depending on the electron energy distribution and the target density profile the hot electrons can either increase the shock amplitude or preheat the imploding shell. In particular, the exponential electron energy spectrum corresponding to the temperature of 30\u00a0keV in the present HiPER target design preheats the deuterium-tritium shell and jeopardizes its compression. Ways of improving the target performance are suggested.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35378911,"openaccessinfo":{"externalids":{"MAG":"2327299888","ACL":null,"DOI":"10.1103\/PHYSREVE.89.033107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to examine the effects of interaction based mother-child art therapy on the change of child and mother's interactions in a child who was in trouble due to attachment problems. The subject in this study was a six-year-old child who faced difficulties in peer relationship building and who were maladjusted to kindergarten because of unstable attachment and negative feedback from his parents. Also, he showed serious problem behaviors at home. The ABA design was adopted among single-subject research designs, and the Target child was observed in the sessions in terms of the subfactors of Marschak's Behavioral Rating Scale to gather data related to the changes of child and mother's interactions. As a result of analyzing the collected data, there were positive changes in all the subfactors that were the child's verbal\/nonverbal interactions, the mother's verbal\/nonverbal interactions and mother-child interactions. Therefore the interaction based mother-child art therapy that was designed to boost child and mother's interactions was effective at furthering the mother-child interactions of the child with attachment problems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":152180398,"openaccessinfo":{"externalids":{"MAG":"2553792982","ACL":null,"DOI":"10.13000\/JFMSE.2016.28.5.1395","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: malignant glaucoma after cataract surgery is still one of the serious complications, if not handled properly,it may lead to serious consequences. It is notoriously difficult to treat. 25G vitrectomy was performed to evaluate the safety and efficacy for the treatment of malignant glaucoma in pseudophakia. Methods: This is a retrospective, comparative case series study. A total of 20 eyes of 20 patients with malignant glaucoma after phacoemulsification were analyzed retrospectively in The First Affiliated Hospital Of Anhui Medical University from May 2015 to January 2018. All Medical Data including the best corrected visual acuity (BCVA), Change of intraocular pressure (IOP), the length of eye axis, and the depth of anterior chamber were recorded. SPSS 17.0 statistical software was used for analysis .Before surgery, the best corrected visual acuity (BCVA) was 1.8\u00b10.6. The intraocular pressure was between 18-57mmHg, with an average of 35.2\u00b110.4mmHg.The depth of anterior chamber was between 0.9-1.9mm, with an average of 1.3\u00b10.2mm.The length of eye axis was 19.7-22.5mm,with an average of 20.6\u00b10.5mm.All the patients were accomplished with 25G vitrectomy. Besides, anterior chamber inflammatory reaction and other complications were also observed postoperation. Results: The patients were followed up for 6-12 months with an average of 9 months. BCVA at the last follow up improved to 0.8\u00b10.1, and there was significant difference compared to that before operation (P<0.01).IOP was from 12-19mmHg, an average of 16.1\u00b12.5mmHg, there was significant difference compared to that before operation (t=7.6, p<0.01).Only one patient occurred low IOP (6mmHg) after surgery, IOP returned to normal level (14mmHg) after conservative treatment. No serious complications including corneal endothelium decompensation, intraocular lens (IOL) capture, intraocular hemorrhage, endophthalmitis and uncontrolled IOP were observed. Conclusions: 25G minimally invasive vitrectomy can treat malignant glaucoma after cataract surgery safely and effectively","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":240669422,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.2.13438\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-4150\/v1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"From 1967, up until his death, Eduardo Paolozzi was involved with the innovative British literary magazine Ambit, using its pages as a space for some of his most experimental and innovative creations, pushing at the \nboundary between text and image. Collages, visual essays and fragments from novels, drawing on pop culture images from newspapers, magazines and \nadvertisements. Reprinted in their entirety for the first time, Paolozzi's works for Ambit tackle the war in Vietnam, the acceleration of Japanese technology, and the utopias of mass advertising. \n \nThe Jet Age Compendium reproduces the Paolozzi pages from Ambit along with magazine covers, poems and advertisements that originally appeared alongside the artist's work. The book is housed in a day-glo pink \nsleeve that also contains an essay written by David Brittain which puts Paolozzi's work for the magazine into context.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":194194795,"openaccessinfo":{"externalids":{"MAG":"2199838442","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The cognitive mechanisms underlying the processing of non-adjacent syntactic dependencies are critical for the understanding of human language processing. For instance, a verb needs to be syntactically and semantically integrated with its subject, or a reflexive like himself needs to be syntactically bound by its antecedent before it can be assigned any meaning. Thus, when processing the second part of a syntactic dependency, the parser needs to retrieve the corresponding first part of this dependency. The mechanisms underlying these syntactically triggered retrieval processes have drawn considerable attention in psycholinguistic research. Lewis and Vasishth (2005) (LV05) developed a model of sentence processing which is based on the general cognitive architecture ACT-R (Anderson et al., 2004). This model assumes a content-addressable memory in which cue-based retrieval processes are subject to similarity-based interference from (partially) cue-matching distractors. The LV05 model has widely been used to explain interference effects observed in the processing of syntactic dependencies such as reflexive-antecedent or subject-verb dependencies. Although the model is able to capture some of the empirically observed effects, there is a range of data the model is unable to explain. We propose to extend the LV05 model by two independently motivated assumptions, namely cue confusion and activationsensitive interference. We demonstrate that this extended model explains a wide range of empirically observed effects the original LV05 model does not account for.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":64423851,"openaccessinfo":{"externalids":{"MAG":"2576677963","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The samples were obtained by a rapid-quenching technique at 1430 degrees C in a Y-Ba-Cu-O system. The amorphous-to-crystalline transformation of YBa2Cu3Ox occurred in as-quenched samples during isothermal annealing in an oxygen atmosphere in the range 800-900 degrees C. The variation of electron resistivity of as-quenched samples was measured in situ during isothermal annealing. According to the changes of electron resistivity, it was suggested that the rate of the transformation process was mainly controlled by the rate of oxygen diffusion in the tetragonal YBa2Cu3Ox. The activation energy of the crystallization process obtained was Delta E=1.18 eV.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250755913,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0953-2048\/5\/7\/003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Flooding is a concern phenomenon, especially in the context of climate change (CC) and sea level rise. This work aimed to establish indicators used to assess vulnerability (V) due to inundation on the basis of considering the exposure (E), sensitivity (S) and adaptive capacity (AC) of a system. By literature review, data analysis, and expert methods, 33 indicators for assessing vulnerability due to inundation were established, including 4 E, 11 S (divided into 4 groups: society, economic, environment, and land use), and 18 AC indicators (divided into 4 groups: human, financial, infrastructure, and society). This work resulted in an important basis for comprehensive evaluation of vulnerability due to inundation in the context of CC and proposing suitable solutions.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":202198057,"openaccessinfo":{"externalids":{"MAG":"2968843790","ACL":null,"DOI":"10.32508\/STDJNS.V2I4.824","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During a survey on fungi associated with decline symptoms on grapevine cultivars growing in Kurdistan region of Iraq, several isolates of Botryosphaeria species were encountered. All isolates were identified as Botryosphaeria parva Pennycook and Samuels. Pathogenicity test for isolate DKI 1 was performed on two cultivars, Taefi and Rashmew. Under greenhouse conditions, one-year grape rooted cuttings were inoculated with the pathogen isolate by two methods, injecting the spore suspension into the green shoots and by artificial inoculation of wounded shoots with mycelial mat. The highest canker length (15.0 mm) was produced after four months on the shoots of the Taife cultivar artificially inoculated with mycelial mat of the pathogen. Under field conditions, two methods of inoculation were adopted, wounding the green shoots and drilling a hole in the arms of mature vine, followed by inoculation with mycelial mat. The highest canker length (11.17 mm) was obtained after 5 months on wounded shoots of the Rashmew cultivar and with a significant difference from the Taefi cultivar. The pathogen caused a reduction in fresh and dry weight of green shoots and roots compared with the non-inoculated control. This is the first report on B. parva in Iraq.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":155096460,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Normal liver contains mainly heparan sulfate proteoglycans. To determine which liver cells are able to express syndecan-1 RNA, hepatocytes, endothelial, Kupffer and Ito cells were isolated from normal rat liver and kept in culture. Rat fibroblasts, monocytes and peritoneal macrophages were also studied. Immediately after isolation the steady state level of syndecan messages in hepatocytes was comparable to that of the normal liver. The expression increased at day one and then remained constant until day five. Ito and endothelial cells contained a low amount of syndecan message. Freshly isolated Kupffer cells failed to express syndecan, but strong upregulation was found on the first day in culture which gradually decreased by day 5. Syndecan transcripts were dose and time dependently upregulated by endotoxin and gamma interferon in Kupffer cells. Endotoxin had no effect on fibroblasts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45839169,"openaccessinfo":{"externalids":{"MAG":"2005937949","ACL":null,"DOI":"10.1006\/BBRC.1994.2551","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"American recognition for medical pluralism arrived in 1991. The National Center for Complementary and Alternative Medicine was established under the National Institutes of Health in 1998. Following this, patients and researchers began exploring use of integrative medicine. Terence Ryan with Gerry Bodeker in Europe, Brian Berman in America, and the Indian council of Medical Research advocated traditional medicine and integrative medicine. The Institute of Applied Dermatology (IAD), Kerala has developed integrated allopathic (biomedical) and ayurvedic therapies to treat Lymphatic Filariasis, Lichen planus, and Vitiligo. Studies conducted at the IAD have created a framework for evidence-based and integrative dermatology (ID). This paper gives an overview of advances in ID with an example of Lichen Planus, which was examined jointly by dermatologists and Ayurveda doctors. The clinical presentation in these patients was listed in a vikruthi table of comparable biomedical terms. A vikruthi table was used for drug selection in ayurvedic dermatology. A total of 19 patients were treated with ayurvedic prescriptions to normalize the vatha-kapha for 3 months. All patients responded and no side effects were recorded. In spite of advancing knowledge on ID, several challenges remain for its use on difficult to treat chronic skin diseases. The formation of new integrative groups and financial support are essential for the growth of ID in India.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22643968,"openaccessinfo":{"externalids":{"MAG":"2019424652","ACL":null,"DOI":"10.4103\/0019-5154.108046","PubMedCentral":"3657212","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/0019-5154.108046","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Using high-resolution magnetohydrodynamic simulations of idealized, non-cosmological galaxies, we investigate how cooling, star formation and stellar feedback affect galactic magnetic fields. We find that the amplification histories, saturation values and morphologies of the magnetic fields vary considerably depending on the baryonic physics employed, primarily because of differences in the gas density distribution. In particular, adiabatic runs and runs with a subgrid (effective equation of state) stellar feedback model yield lower saturation values and morphologies that exhibit greater large-scale order compared with runs that adopt explicit stellar feedback and runs with cooling and star formation but no feedback. The discrepancies mostly lie in gas denser than the galactic average, which requires cooling and explicit fragmentation to capture. Independent of the baryonic physics included, the magnetic field strength scales with gas density as B \u221d n^(2\/3), suggesting isotropic flux freezing or equipartition between the magnetic and gravitational energies during the field amplification. We conclude that accurate treatments of cooling, star formation and stellar feedback are crucial for obtaining the correct magnetic field strength and morphology in dense gas, which, in turn, is essential for properly modelling other physical processes that depend on the magnetic field, such as cosmic ray feedback.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":55255053,"openaccessinfo":{"externalids":{"MAG":"2765474576","ACL":null,"DOI":"10.1093\/mnrasl\/slx172","PubMedCentral":null,"ArXiv":"1710.05932"},"license":null,"url":"https:\/\/academic.oup.com\/mnrasl\/article-pdf\/473\/1\/L111\/24841352\/slx172.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Time-series prediction is an important statistical topic to help researchers in planning and making the right decisions, so this study deals with modern prediction methods, represented by the Artificial Neural Network models, specifically the multi-layered neural network, and the back propagation algorithm has been relied upon several times for training and less selection. A value for error to obtain the best model for describing the data, as well as classic prediction methods such as Box- Jenkins' models, the model was applied to real data represented by the number of people infected with Coronavirus (Covid-19) in Iraq for the period from 2\/24\/2020 until 3\/5\/ 2020 On a daily basis, the results showed that future predictions for the number of people infected with Coronavirus began to decline and then stabilized in the period (30-67). The data were analyzed and the results were extracted depending on the statistical program R.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234287102,"openaccessinfo":{"externalids":{"MAG":"3148466036","ACL":null,"DOI":"10.29350\/QJPS.2021.26.1.1236","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Patents Amendment Bill does not go far enough to develop a holistic framework for the protection of indigenous knowledge. It thus leaves several loopholes through which biopiracy and usurpation of indigenous knowledge can easily take place. A more synergistic relationship between the patent authority and the National Biodiversity Authority, and a more transparent and inclusive decision-making process, will help remove some of the shortcomings in the bill.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":150798899,"openaccessinfo":{"externalids":{"MAG":"43508653","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract This paper aims to introduce a framework to measure the sustainable performance of the supply chain (SC) during the COVID-19 pandemic. The SC stakeholders in this investigation are Suppliers, Production \/ Remanufacturing \/ Refurbishing Centers (Factories), Collection \/ Distribution Centers, Recycling \/ Landfill Centers, and Customers. The suggested sustainable supply chain (SSC) performance measurement included three pillars with 23 indicators. To evaluate the overall sustainability of the SC understudy, a composite index has been developed that combines all the indicators to reflect the sustainability performance of the SC. Four steps are involved in creating a composite index:1) measuring the value of indicators, 2) weighing indicators, 3) Using the normalization technique, and 4) Evaluating the overall SSC indicator. The real case in Iran is selected as an illustrative case. Our research contributions are: We suggested a novelty indicator of SSC to better show the economic, environmental, and social tradeoffs during the COVID-19 pandemic and lockdowns. We have found and measured the negative and positive impacts of COVID-19 on aspects of sustainability in SC. Based on the achieved data of the real case study, a numerical example is represented to explain how to calculate the composite index. The main contribution of this paper is the development of SSC indicators during the COVID-19 epidemic.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":2}},"corpusid":254592749,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2478\/fcds-2022-0018","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/sciendo.com\/pdf\/10.2478\/fcds-2022-0018","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Apomorphine-induced hyperthermia in the rabbit was shown to be dependent upon the presence of stressors. Two types of stressors were used: 1) a physical stressor, foot shock; and 2) an emotional stressor, conditioned fear. Apomorphine (4 mg\/kg i.v.), in the absence of a stressor, produced behavioral responses of arousal, stereotypic gnawing and hind foot thumping. Foot shock, which in control animals exerted no temperature effects, when paired with apomorphine administration, produced a hyperthermic response of 1.3 degrees C. This hyperthermia was abolished by pretreatment with diazepam (5 mg\/kg i.v.) or haloperidol (50 micrograms\/kg i.v.). Classical conditioning was used to provide the emotional stressor and was accomplished by pairing a tone with foot shock. After conditioning the tone combined with apomorphine produced an increase in temperature of 1.3 degrees C, whereas the tone paired with saline (1 ml\/kg i.v.) produced no hyperthermia. An intensity vs. effect curve was determined, and foot shock alone elicited increases of temperature in a dose-dependent manner. At a given shock intensity, apomorphine elicited a much greater response than shock alone and also decreased the threshold for response to shock. Our findings firmly establish the hypothesis that apomorphine elicits hyperthermia in the presence of stressors by increasing sensitivity and decreasing the threshold for response to stressors.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":12079037,"openaccessinfo":{"externalids":{"MAG":"2262699903","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract\u2014Angiotensin II has emerged as an important growth factor for vascular, cardiac, and renal cells. Depending on the specific cell type and presence of other growth factors, angiotensin II induces proliferation (replication of DNA with subsequent successful division of cells), hypertrophy (increase in cell size, cell protein, and mRNA content without DNA replication), apoptosis (programmed cell death), or differentiation. Such angiotensin II-mediated modulation of growth process may underlie various pathophysiological processes such as atherosclerosis, vascular and cardiac remodeling, and progression of chronic renal disease. Clearly, angiotensin II-induced proliferation requires complete cell progression through the various steps of the cell cycle. In contrast, cells undergoing angiotensin II-mediated hypertrophy are arrested in the G1-phase. Upregulation of cell cycle-dependent kinase inhibitors (eg, p27Kip1) plays an important role in this process. Although accumulating evidence suggests that apoptosis is cell cycle-dependent, only few data are currently available concerning the interaction of angiotensin II with the cell cycle machinery in apoptosis. We review the various angiotensin II-mediated growth processes and their relationship to events governing cell cycle regulation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6396087,"openaccessinfo":{"externalids":{"MAG":"2163113987","ACL":null,"DOI":"10.1161\/01.HYP.0000120963.09029.ca","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Thanks to the advent of big data, computational linguistics has made great advances in understanding one of the most fundamental human faculties: the ability to generate and process meaning. The field's scientiic breakthroughs underpin much of our digital lives, from Web search to conversational agents. But those breakthroughs rely on the availability of freely accessible language data. As more and more valuable data is concentrated in the hands of a few corporate entities, and research agendas are set by the market, it is unclear who is to own and control the technology. I argue for giving users a direct inluence over language sciences. ----- Bibliographie: Herbelot, Aurelie: Terminators and pears. Why computational linguistics matters, 360\u00b0, 2-2015, S. 85-92. https:\/\/doi.org\/10.3224\/360grad.v10i2.21809","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":61816689,"openaccessinfo":{"externalids":{"MAG":"2247555506","ACL":null,"DOI":"10.3224\/360GRAD.V10I2.21527","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"children, the section on clinical investigation is least satisfying. Though most practising paediatricians will be familiar with a large proportion of the material in this book, the several chapters consolidate the background of therapeutic choice. Much of the basic information can be abstracted for teaching, and extensive lists of references lead one to the original researches. Practitioners and senior students will find readable accounts of important aspects of therapy. The specialist research worker will not in any case be looking in this direction for references.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73398211,"openaccessinfo":{"externalids":{"MAG":"2145954768","ACL":null,"DOI":"10.1097\/00006534-197311000-00019","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/europepmc.org\/articles\/pmc5205627?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In order to analyze the pattern in the geographical distribution of cancer death in 24 countries of the world, correlation coefficients were calculated between pairs of mortality rates of different cancer sites, using the data for 13 sites in males and 14 sites in females over 18 years from 1950 to 1967. Then factor analysis by means of varimax method was performed on 13 x 13 correlation matrix for males, 14 x 14 correlation matrix for females and 27 x 27 correlation matrix for males and females combined. As a result of factor analysis, three factors are extracted, which are commonly recognized in both males and females. The first factor has high positive factor loadings on pancreas, prostate (for males), skin, and intestine cancers, and negative loadings on stomach and liver cancers. The second factor has high positive factor loading on rectum, intestine, and lung cancers, and the third factor on larynx, oral, and esophagus cancers. Factor analysis based on 27 x 27 correlation matrix revealed that the third factor of both sexes are heterogeneous with regards to the distributions of the factor score. In order that we may find some clues to develop an etiological hypothesis for each site of cancer, we obtained the correlation coefficient between the scores of the extracted factors and the variables on food and environmental agent, and performed stepwise regression methods as well. One of the most striking results we obtained was that excessive drinking of alcohol and the lack of appropriate intake of fruit are suspected as etiological promoters in the pathogenesis of oral, esophagus, and larynx cancers in males.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13080079,"openaccessinfo":{"externalids":{"MAG":"2047191415","ACL":null,"DOI":"10.1289\/EHP.793283","PubMedCentral":"1637926","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nGuidelines indicate the need to balance the risks of opioid prescribing with the need to adequately manage pain after cesarean section (CS). Although guidelines suggest the need for tailored opioid prescribing, it is unclear whether providers currently tailor opioid prescribing practices given patient-related factors. Thus, research is needed to first understand post-CS pain management and opioid prescribing. The objective of the present study was to identify factors related to CS discharge opioid prescriptions.\n\n\nMATERIAL AND METHODS\nThis retrospective cohort study was approved by the Brooke Army Medical Center Institutional Review Board (San Antonio, Texas; #C.2020.094e) on June 23, 2020. Electronic health record data of healthy adult women undergoing primary elective CS, performed under regional neuraxial anesthesia at a single, academic, tertiary medical center from 2018 to 2019, were included. Multivariable regression examined patient and medical factors associated with post-CS opioid prescriptions.\n\n\nRESULTS\nIn the present sample (N\u2009=\u2009169), 23% (n\u2009=\u200939) of patients did not use opioids postoperatively, while inpatient and almost all of those patients (n\u2009=\u200936) received a discharge prescription for opioids with a median amount of 225 morphine milligram equivalent doses. There was a lack of evidence indicating that patient and medical factors were associated with discharge opioid dose.\n\n\nCONCLUSION\nPatient and medical factors were not associated with post-CS opioid prescribing. Larger studies are needed to better elucidate optimal post-CS pain management in the days and months that follow CS. Such findings are needed to better tailor opioid prescribing, consistent with clinical practice guidelines.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235744525,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/milmed\/usab263","PubMedCentral":null,"ArXiv":null},"license":"public-domain","url":"https:\/\/academic.oup.com\/milmed\/advance-article-pdf\/doi\/10.1093\/milmed\/usab263\/38871924\/usab263.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Biological systems are intrinsically noisy and this noise may determine the qualitative outcome of the system. In the absence of analytical solutions to mathematical models incorporating noise, stochastic simulation algorithms are useful to explore the possible trajectories of these systems. Algorithms used for such stochastic simulations include the Gillespie algorithm and its approximations. In this study we introduce cayenne, an easy to use Python package containing accurate and fast implementations of the Gillespie algorithm (direct method), the tau-leaping algorithm and a tau-adaptive algorithm. We compare the accuracy of cayenne with other stochastic simulation libraries (BioSimulator.jl, GillespieSSA and Tellurium) and find that cayenne offers the best trade-off between accuracy and speed. Additionally, we highlight the importance of performing accuracy tests for stochastic simulation libraries, and hope that it becomes standard practice when developing the same. The cayenne package can be found at https:\/\/github.com\/Heuro-labs\/cayenne while the bench-marks can be found at https:\/\/github.com\/Heuro-labs\/cayenne-benchmarks","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":222803010,"openaccessinfo":{"externalids":{"MAG":"3092386545","ACL":null,"DOI":"10.1101\/2020.10.10.334623","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2020\/10\/10\/2020.10.10.334623.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Traditionally, palliative care (PC) systems focused on the needs of advanced cancer patients, but most patients needing PC have end-stage organ diseases. Similarly, PC models focus on the needs of patients in hospices or at home; however, in most cases PC is provided in acute hospitals. Indeed, the symptom burden that these patients experience in the last year of life frequently forces them to seek care in emergency departments. The majority of them are admitted to the hospital and many die. This issue poses important concerns. Despite the efforts of attending healthcare professionals, in-hospital patients do not receive optimal care near the end-of-life. Also, evidence is emerging that delay in identifying patients needing PC have a detrimental impact on their quality of life (QoL). Therefore, there is an urgent need to identify, early and properly, these patients among those hospitalized. Several trials reported the efficacy of PC in improving the QoL in these patients. Each hospital should ensure that a multidisciplinary PC team is available to support attending physicians to achieve the best QoL for both PC patients and their families. This review discusses the role and the impact of in-hospital PC in patients with end-stage disease or advanced cancer.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3986408,"openaccessinfo":{"externalids":{"MAG":"2778610221","ACL":null,"DOI":"10.3390\/jcm7020018","PubMedCentral":"5852434","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2077-0383\/7\/2\/18\/pdf?version=1517328069","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The tribological behaviors were investigated in a new high strength and wear resistant aluminum bronze, with its friction coefficient and wear-rate lower than those of ZQAl9-4 and ZQAl10-4-4 alloys in terms of Chinese national standard.The results showed that different tribological behaviors were attributed material itself. Under boundary lubrication condition, major wear mechanisms of aluminum bronze are adhesive wear and attrition wear. Its wearability depends mainly on material microstructure, shedding hard-particles, rakes and small pits that can store lubricant. The new aluminum bronze may find wide application in high sliding speed, heavy load and boundary lubrication condition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":136722324,"openaccessinfo":{"externalids":{"MAG":"1022895852","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Arrestin is involved in the quenching of phototransduction by binding to photoactivated and phosphorylated rhodopsin (P\u2010Rho*). To study its conformational changes and regions interacting with P\u2010Rho*, arrestin was subjected to (1) differential acetylation at lysine residues in the presence and absence of P\u2010Rho*, and (2) amide hydrogen\/deuterium exchange. Labeled protein was proteolysed and analyzed by mass spectrometry. Three Lys residues, 28, 176, and 211, were protected from acetylation in native arrestin, although they were not located in regions exhibiting slow amide hydrogen exchange rates. The presence of P\u2010Rho* protected lysine 201 from acetylation and partially protected 14 other lysyl residues, including (2, 5), (163, 166, 167), (232, 235, 236, 238), (267, 276), (298, 300), and 367, where parentheses indicate lysine residues found within the same peptide. In contrast, in the C\u2010terminal region of arrestin, lysyl residues (386, 392, 395) were more exposed upon binding to P\u2010Rho*. These data allowed us to identify functional regions in the arrestin molecule.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46045661,"openaccessinfo":{"externalids":{"MAG":"2084888272","ACL":null,"DOI":"10.1002\/PRO.5560031226","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We examine the behavior of single photons at multiport devices and inquire if coherent effects are possible. In particular we study how single photons need to be manipulated in order to study coherent phenomena. We show that single photons need to be produced in W states which lead to vanishing mean amplitude but nonzero correlations between the inputs at different ports. Such correlations restore coherent effects with single photons. As a specific example we demonstrate Bloch oscillations with single photons and thus provide strict analog of Bloch oscillation of electrons.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119203862,"openaccessinfo":{"externalids":{"MAG":"2036213775","ACL":null,"DOI":"10.1103\/PhysRevA.79.053849","PubMedCentral":null,"ArXiv":"0902.1462"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The multilevel item response theory (MLIRT) models have been increasingly used in longitudinal clinical studies that collect multiple outcomes. The MLIRT models account for all the information from multiple longitudinal outcomes of mixed types (e.g., continuous, binary, and ordinal) and can provide valid inference for the overall treatment effects. However, the continuous outcomes and the random effects in the MLIRT models are often assumed to be normally distributed. The normality assumption can sometimes be unrealistic and thus may produce misleading results. The normal\/independent (NI) distributions have been increasingly used to handle the outlier and heavy tail problems in order to produce robust inference. In this article, we developed a Bayesian approach that implemented the NI distributions on both continuous outcomes and random effects in the MLIRT models and discussed different strategies of implementing the NI distributions. Extensive simulation studies were conducted to demonstrate the advantage of our proposed models, which provided parameter estimates with smaller bias and more reasonable coverage probabilities. Our proposed models were applied to a motivating Parkinson's disease study, the DATATOP study, to investigate the effect of deprenyl in slowing down the disease progression.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20783908,"openaccessinfo":{"externalids":{"MAG":"2219828210","ACL":null,"DOI":"10.1002\/bimj.201400255","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc5064853?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Hypertension is one of the major causes of disease and disability worldwide. It is associated with an increased risk of stroke and myocardial infarction etc.It is easy to detect by simple means, but most of them are unaware of their hypertension and had no treatment. In those on treatment, blood pressure control is unsatisfactory. The factors affecting the prevalence of hypertension are many that including ethnicity, life style changes and diet. Epidemiological data shows variation in prevalence of hypertension. Some show an increase in blood pressure with age, while others show no significant increase. Present study examined 1016 (M: 500; F: 516) from local fisherman community in the age group of 2070 years. Study showed 4.62% prevalence of hypertension (M: 4.40; F: 4.84) and 40% were aware of their hypertensive state. Only 4.2% were on regular treatment and the rest, noncompliant population had uncontrolled blood pressure. None had any idea about hypertensive related risk factors, symptoms, complications and preventive measures. Hypertension among fisherman community showed lower prevalence than compared to various prevalence studies in","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":57185721,"openaccessinfo":{"externalids":{"MAG":"1596890113","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we propose a novel method of orientation estimation in seismic data. Unlike conventional methods of orientation estimation with a context window, our method is inspired by the neural mechanism of visual perception. The primary visual cortex in the brain contains orientation columns, which are composed of an array of orientation detectors. A log-Gabor filter with a specific orientation and scale configuration simulates the neuronal mechanism of the orientation detector, while an array of such filters simulates the orientation columns. The resulting orientation is derived at the sample level of the input seismic data: the filter response competes with each other in the array, and the maximum response defines the seismic orientation. Our proposed method has many applications in seismic interpretation, e.g., calculating the volumetric azimuth and dip attributes without picking, guiding seismic attribute computation, and detecting seismic texture patterns.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":130865646,"openaccessinfo":{"externalids":{"MAG":"2320044534","ACL":null,"DOI":"10.1190\/SEGAM2013-0046.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective To study the sociocultural transformation of neurasthenia (shenjing shuairuo, SJSR), as both disease and illness, in Chinese society. Method This is based on a critical review of evidence drawn from the psychiatric and anthropological literature, and the use of a single case study. Results SJSR remains a ubiquitous illness in socio-politically different Chinese societies, but the Americanization of Chinese psychiatry has paradoxically made the \"same\" disease category languish rapidly in professional practice. Although it engages bodily modes of attention, SJSR is far from being a physical, somatoform, or chronic fatigue disorder. Conclusions Psychiatric disease and illness do not run a \"natural\" course independent of social and historical contexts. SJSR usefully muddles the Cartesian mind-body dichotomy and is readily compatible with psychosocial manifestations and explanatory models. From a sociosomatic perspective, the embodied world of SJSR may arbitrate as well as critique the conjunctures of large-scale political, economic, and moral transformations in Chinese communities. These macrosocial forces and their local manifestations need to be considered in deriving a cross-culturally valid paradigm of psychosomatic medicine.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":9717748,"openaccessinfo":{"externalids":{"MAG":"2331479321","ACL":null,"DOI":"10.1097\/00006842-199807000-00010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Notes on the Contributors Introduction: D.Punter PART ONE: THEORY: REGIONS OF THE GOTHIC The Gothic Production of the Unconscious F.Botting Ceremonial Gothic D.Puntert The Nurture of the Gothic, or, How Can a Text be Both Popular and Subversive? W.Veeder PART TWO: HEARTLANDS: THE BRITISH NINETEENTH CENTURY Lost Cities: London's Apocalypse A.Warwick Hell is a City: Symbolic Systems and Epistemological Scepticism in The City of Dreadful Night D.Seed 'A Pestilence Which Walketh in Darkness': Diagnosing the Victorian Vampire R.Mighall PART THREE: AMERICA: STATES OF INSTABILITY American Gothic Landscapes: The New World to Vietnam J.Idiart & J.Schulz Gothic Numbers in the New Republic: The Federalist No. 10 and its Spectral Factions H.F. Thompson Spectres of Abjection: The Queer Subject of James's 'The Jolly Corner' E.Savoy PART FOUR: EUROPE: DIMENSIONS OF THE BODY The Gothic and 'Otherings' of Ascendant Culture: The Original Phantom of the Opera J.Hogle Heiner Muller's Medea: Towards a Paradigm for the Contemporary Gothic Anatomy B.Turner PART FIVE: (RE)VERSIONS Deaths in Venice: Daphne du Maurier's 'Don't Look Now' A.Horner & S.Zlosnik Dr McGrath's Disease: Radical Pathology in Patrick McGrath's Neo-Gothicism C.Ferguson Index","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144030581,"openaccessinfo":{"externalids":{"MAG":"2011687717","ACL":null,"DOI":"10.2307\/3588153","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In an earlier paper concerning classification of aspirated May\u2010Gr\u00fcnwald\u2010Giemsa stained malignant tumour cells from lung lesions, we found the sensitivity to be 80\u201395 per cent for adenocarcinomas, undifferentiated carcinomas and small cell carcinomas. For epidermoid carcinomas the sensitivity was only 64 per cent. It was therefore found of interest to see if a registration of the non\u2010neoplastic cells could be an aid in the cytological tumour cell classification. An analysis has been performed of the distribution of the non\u2010neoplastic cells in 71 aspiration biopsies from six different types of malignant lung tumours. A variegated population of many and different types of inflammatory cells, mast cells and alveolar epithelial cells was a characteristic finding in biopsies from neoplasms with an epidermoid differentiotion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":560881,"openaccessinfo":{"externalids":{"MAG":"1999889236","ACL":null,"DOI":"10.1111\/J.1699-0463.1978.TB02062.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Russian historians have traditionally seen the church as merely the handmaiden of the state. Yet in the realm of foreign policy the heads of the Orthodox Church in Russia played a distinct role from the end of the fifteenth century to peter's time. They were participants in the most important decisions (though not in routine affairs), especially about war and peace. In wartime the metropolitans and bishops produced exhortations to the army. In the sixteenth century these were not only calls to fight the infidel but frequently sermons to the Russians to be better Christians. After the mid-seventeenth century the sermons at the time of war, now in Western rhetorical style, came from a wider group of clergy and were more uniformly calls to fight for Orthodoxy. In Peter's time such sermons became secular justifications for the wars.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225380225,"openaccessinfo":{"externalids":{"MAG":"3080911964","ACL":null,"DOI":"10.30965\/22102396-05401004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Integrated training of field workers was initiated in 1978 with a week training course in family planning maternal and child health and tuberculosis control. This course provided orientation. In 1979 a 2 week course actually preparing workers for their field activities was inaugurated. Data collected from 182 field workers who attended the course in 1979 are analyzed here. Mean age of workers was 23.6 3.4 years lower than a 1971 survey revealed. All workers were licensed while in 1971 39% were without licenses. 32.8% were dissatisfied with their current job (51.8% among maternal and child health workers). Improved pay and working environment is urgently needed. Most workers were satisfied with the 2 week course and responded favorably to the lecturers although a few wished to have more contact with the training staff. Audiovisual materials were considered adequate but could be improved. Printed materials were generally well accepted. Practice and demonstration sessions were shown to be effective while case study and field observation were not; improvement is needed in these areas. The trainees were generally enthusiastic about the program and hopeful about their contributions to integration. More time for study and review was urged and a continuous effort at curriculum development and operational improvement of the training program is needed. (Authors modified) (Summary in ENG)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58132708,"openaccessinfo":{"externalids":{"MAG":"2202733706","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This book introduces a general method for building infinite mathematical structures, and surveys its applications in algebra and model theory. The basic idea behind the method is to build a structure by a procedure with infinitely many steps, similar to a game between two players that goes on indefinitely. The approach is new and helps to simplify, motivate and unify a wide range of constructions that were previously carried out separately and by ad hoc methods. The first chapter provides a resume of basic model theory. A wide variety of algebraic applications are studied, with detailed analyses of existentially closed groups of class 2. Another chapter describes the classical model-theoretic form of this method -of construction, which is known variously as 'omitting types', 'forcing' or the 'Henkin-Orey theorem'. The last three chapters are more specialised and discuss how the same idea can be used to build uncountable structures. Applications include completeness for Magidor-Malitz quantifiers, and Shelah's recent and sophisticated omitting types theorem for L(Q). There are also applications to Bdolean algebras and models of arithmetic.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":34634710,"openaccessinfo":{"externalids":{"MAG":"1488454741","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The mechanism of follow current has been studied using a synthetic power source In conjunction with a Marx Impulse generator circuit, and air gaps of up to 1.6 cm. The performance of the circuit has been established analytically and experimentally, and the suitability of synthetic power circuits for follow current studies has been confirmed by the results of this investigation. A resistance divider with Inherent voltage limiting characteristics was essential for recording the discharge voltage between the electrodes. A method was devised and was shown, both by analysis end experiment, to have the required characteristics. The experimental technique having been established, a study has been carried out of the effects of variation in power and impulse circuit parameters, and in electrode material, shape, spacing, and surface condition. Three types of follow current have been defined, and their mechanisms have been explained. A close relation has been shown to exist in many cases between the conditions under which the establishment of follow current is just possible, and those required for arc-glow and glow-arc transitions in the test gap. Criteria which determine the establishment of follow current have been derived; A large number of variables has been shown to be involved in this problem, and their relative importance has been discussed. Recommendations have been made for further studies, as well as for the control of variables in industrial tests.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":210521946,"openaccessinfo":{"externalids":{"MAG":"2977358703","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Elevated thrombospondin 1 (TSP1) is a prevalent factor, via cognate receptor CD47, in the pathogenesis of cardiovascular conditions, including ischemia-reperfusion injury (IRI) and pulmonary arterial hypertension (PAH). Moreover, TSP1\/CD47 interaction has been found to be associated with platelet hyperaggregability and impaired nitric oxide response, exacerbating progression in IRI and PAH. Pathological TSP1 in circulation arises as a target of our novel therapeutic approach. Our \"proof-of-concept\" pharmacological strategy relies on recombinant human CD47 peptide (rh-CD47p) as a decoy receptor protein (DRP) to specifically bind TSP1 and neutralize TSP1-impaired vasorelaxation, strongly implicated in IRI and PAH. The binding of rh-CD47p and TSP1 was first verified as the primary mechanism via Western blotting and further quantified with modified ELISA, which also revealed a linear molar dose-dependent interaction. Ex vivo, pretreatment protocol with rh-CD47p (rh-CD47p added prior to TSP1 incubation) demonstrated a prophylactic effect against TSP1-impairment of endothelium-dependent vasodilation. Post-treatment set-up (TSP1 incubation prior to rh-CD47p addition), mimicking pre-existing excessive TSP1 in PAH, reversed TSP1-inhibited vasodilation back to control level. Dose titration identified an effective molar dose range (approx. \u22651:3 of tTSP1:rh-CD47p) for prevention of\/recovery from TSP1-induced vascular dysfunction. Our results indicate the great potential for proposed novel decoy rh-CD47p-therapy to abrogate TSP1-associated cardiovascular complications, such as PAH.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235643550,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/biomedicines9060642","PubMedCentral":"8228143","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2227-9059\/9\/6\/642\/pdf?version=1622717049","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objective Attention-deficit\/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM). Methods In the present study, a total of 36 medication na\u00efve children with ADHD (aged from 8 to 15 years) and 36 age- and gender-matched healthy control (HC) children were included. The digit span test was used to evaluate WM. The magnetic resonance imaging (MRI) was used to examine the characteristics of cortical morphology. Firstly, we compared the cortical morphology features between two groups to identify the potential structural alterations of cortical volume, surface, thickness, and curvature in children with ADHD. Then, the correlation between the brain structural abnormalities and WM was further explored in children with ADHD. Results Compared with the HC children, the children with ADHD showed reduced cortical volumes in the left lateral superior temporal gyrus (STG) (p=6.67\u00d710-6) and left anterior cingulate cortex (ACC) (p=3.88\u00d710-6). In addition, the cortical volume of left lateral STG was positively correlated with WM (r=0.36, p=0.029). Conclusion Though preliminary, these findings suggest that the reduced cortical volumes of left lateral STG may contribute to the pathogenesis of ADHD and correlate with WM in children with ADHD.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-22":1,"unknown":2}},"corpusid":236884944,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.30773\/pi.2020.0333","PubMedCentral":"8328834","ArXiv":null},"license":null,"url":"https:\/\/www.psychiatryinvestigation.org\/upload\/pdf\/pi-2020-0333.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The brain produces an electromagnetic wave throughout the day and the strength of this wave depends on the activity of the brain. It is said that this wave is a weak wave which does not cover a greater distance. But I do believe that it is like the radio wave in the distance it covers and frequency it possesses. I do believe that there is a communication between individuals through electromagnetic wave (brain wave) and a gas (Nitric Oxide) produced by the brain. This can be observed in our daily experiences. This can also help us understand that as a computer can receive and record the brain waves, so an individual can also receive and integrate these waves and it is being decoded to release the message it contains. In this respect, it can be said that the state of consciousness in an individual can be understood by another through concentration.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":146178818,"openaccessinfo":{"externalids":{"MAG":"2162669684","ACL":null,"DOI":"10.4236\/NM.2014.51004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We systematically studied the effect of current ripple on the determination of n-value, which is the index of the shape of the electric field-current (E-I) curve. Commercial Nb3 S n wires were measured with controlled amounts of ac ripple. Substitution- box, superconductor simulator circuits were also measured. A battery-powered current supply was used to provide the dc with ripple currents. The ripple frequencies were 60,120, and 360 Hz, to represent common electrical power harmonics in high-current power supplies. A previous study focused on the effect of ripple on the determination of dc critical current (Ic); the current study focuses on how ripple changes the n-value and shows that ripple has a larger effect on n-value than on Ic. We examined models and measurements on simulators to reproduce and explain the effects observed in measurements on superconductors. Current ripple and spikes may be sources of differences in n-values measured at different laboratories.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":2044923,"openaccessinfo":{"externalids":{"MAG":"2126720243","ACL":null,"DOI":"10.1109\/TASC.2007.899592","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT In a nature reserve, in Ticino canton in Switzerland amidst a mixed population of non-native Impatiens parviflora and I. glandulifera aberrant plants of I. parviflora were observed. A herbarium voucher and seeds were collected and seedlings subsequently raised in a greenhouse. Molecular analysis for ITS region and chloroplast markers revealed the plants to be a hybrid between I. parviflora and I. balfourii, another non-native Impatiens species occurring in the Ticino canton. No crossing out nor reduced fertility was observed in F2 and F3 generations, raised in a greenhouse. Sizeable populations of the hybrid have been observed in 2014 in the Ticino canton in the absence of the parental species. Nuclear genome size as measured by flow cytometry with propidium iodide did not indicate polyploidy and the ITS region remained 100% uniform. Therefore a homoploid hybrid speciation event is assumed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109605211,"openaccessinfo":{"externalids":{"MAG":"2924095838","ACL":null,"DOI":"10.1080\/23818107.2019.1584863","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/figshare.com\/ndownloader\/files\/14933777","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND: There have been several attempts in the past centuries to quantify the human intelligence, many of these attempts were successful. On the other hand, there have been parallel trials to identify and quantify an individual's creativity. To date, there is no universal definition of creativity nor a quantifying system to measure it with a reliable accuracy.MATERIALS & METHODS: This is a quasi-experimental study in an Iraqi population of undergraduate medical students aged 18-20 years; the male-to-female ratio is 3 to 10. The total number of participants was 195 (n=195) who were allocated into three groups; A, B, and C (nA=67, nB=61, nC=67). Each group was interviewed separately, and the participants were given a choice to either correspond to a quiz on an already taught medical subject or write down ideas (one or more) with creative-innovative potentials. There was no restriction on time, language, or the theme of the topics to be written.RESULTS: There was a significant difference in between the three groups' tendency to take the quiz (p-value=0.040). However, inter-group and intra-group analyses failed to detect any significant difference in students' tendencies towards either a creative or a classical form of thinking. Besides, gender was not found to be of a determinant effect on an individual's tendency towards creativity (p=0.633) or traditional thinking based on an already taught medical knowledge (0.905).CONCLUSION: There were no statistically significant differences in the tendencies of students towards either an original (creative) or a standard pattern of thinking. However, inter-group analyses indicated some substantial differences in students' affinity towards exploring an already taught medical knowledge.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149328284,"openaccessinfo":{"externalids":{"MAG":"2756000137","ACL":null,"DOI":"10.5539\/gjhs.v9n11p186","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.5539\/gjhs.v9n11p186","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Surface coating of cathode materials with Al2O3 has been shown to be a promising method for cathode stabilization and improved cycling performance at high operating voltages. However, a detailed understanding on how coating process and cathode composition change the chemical composition, morphology, and distribution of coating within the cathode interface and bulk lattice is still missing. In this study, we use a wet-chemical method to synthesize a series of Al2O3-coated LiNi0.5Co0.2Mn0.3O2 and LiCoO2 cathodes treated under various annealing temperatures and a combination of structural characterization techniques to understand the composition, homogeneity, and morphology of the coating layer and the bulk cathode. Nuclear magnetic resonance and electron microscopy results reveal that the nature of the interface is highly dependent on the annealing temperature and cathode composition. For Al2O3-coated LiNi0.5Co0.2Mn0.3O2, higher annealing temperature leads to more homogeneous and more closely attached coating on cathode materials, corresponding to better electrochemical performance. Lower Al2O3 coating content is found to be helpful to further improve the initial capacity and cyclability, which can greatly outperform the pristine cathode material. For Al2O3-coated LiCoO2, the incorporation of Al into the cathode lattice is observed after annealing at high temperatures, implying the transformation from \"surface coatings\" to \"dopants\", which is not observed for LiNi0.5Co0.2Mn0.3O2. As a result, Al2O3-coated LiCoO2 annealed at higher temperature shows similar initial capacity but lower retention compared to that annealed at a lower temperature, due to the intercalation of surface alumina into the bulk layered structure forming a solid solution.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":5412861,"openaccessinfo":{"externalids":{"MAG":"2604637449","ACL":null,"DOI":"10.1021\/acsami.7b00595","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/biblio\/1374597","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper investigates data of listed companies of Shenzhen Stock Exchange in 2011-2013, and the result shows that listed companies received government R&D subsidies can get more external financing and the positive impact of the certification effect generated by receiving an R&D subsidy is stronger for equity financing than for debt financing. Furthermore, the effect is more significant in high-tech enterprises.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212601908,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nDysphagia following heart failure (HF) has gained little attention. This study aimed to evaluate the incidence of dysphagia and its associations with the clinical outcomes in HF patients.\n\n\nMETHODS\nThis prospective cohort study included 203 consecutive hospitalized HF patients (mean age 79.5 years, 103 women) without dysphagia before admission. Dysphagia or difficulty swallowing was assessed by the Food Intake Level Scale. The primary outcome was activity of daily living, as assessed by the Barthel Index (BI) at discharge. Secondary outcomes included all-cause mortality and rehospitalization rates at 1 year after discharge. Multivariate analyses and Kaplan-Meier estimates were used to determine whether dysphagia was associated with these outcomes.\n\n\nRESULTS\nOf the 203 patients examined, 48 (23.4%) were diagnosed with dysphagia during admission. Patients who developed dysphagia were significantly older, exhibited lower muscle mass and strength, walked shorter distances, and had lower nutrition intake levels and BI scores (P < 0.05 for all values) compared with those without dysphagia. In the multivariate analyses, the presence of dysphagia at discharge was significantly associated with a lower BI (\u03b2= -0.275, P < 0.001). Furthermore, patients with dysphagia showed a significantly higher 1-year mortality than those without (20.8% vs 1.2%, P = 0.008).\n\n\nCONCLUSIONS\nDysphagia commonly occurs during hospital admission and is associated with functional recovery and 1-year mortality in HF patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":218481890,"openaccessinfo":{"externalids":{"MAG":"3023777231","ACL":null,"DOI":"10.1002\/jpen.1845","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary form only given, as follows. We present capabilities considered necessary for an IBM-9076-based parallel file system and discuss ways that these capabilities can be delivered in an IBM 9076 environment. Expected input\/output performance of both existing serial and specially coded kernels of code are discussed.<>","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":28906487,"openaccessinfo":{"externalids":{"MAG":"1516242293","ACL":null,"DOI":"10.1109\/MASS.1994.373049","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Diabetes mellitus [diabetes] is one of the leading chronic diseases affecting Australians and its prevalence continues to rise at an exponential rate with an estimated 275 Australians developing diabetes daily [1-3]. Globally, the total number of diabetic patients worldwide is estimated to rise to 366 million in 2030 from 171 million in 2000. \n \nEarly detection and management of diabetes is essential. A critical treatment imperative is to provide patients with diabetes appropriate monitoring to enable better assessment and control of blood glucose, and to prevent further complications. As yet, there is no universal cure for diabetes, so what is vital for both patients and the healthcare system is prudent and superior management. Hence, we contend that a pervasive technology solution that can enable ubiquitous (anytime, anywhere, anyplace) monitoring of diabetic patients while also continuously educating them should be a prudent part of such a management program. \n \nObjective: To investigate the benefits of a pervasive technology to facilitate and enable superior self-care for patients suffering from GDM (gestational diabetes) and to answer following research questions: \n\u2022 Can the INET(technology) solution(a solution developed in Canada and successfully trialled in Canada and US) facilitate superior GDM self-management in an Australian context? \n\u2022 What are the benefits and suitability of such a pervasive technology solution to GDM self-care? \n\u2022 What are the key barriers and facilitators for the application of a pervasive technology solution to support GDM patient care? \n \nMethod: The research will subscribe to the established techniques adopted by Wickramasinghe and Goldberg to date; ie the AMR methodology. In addition, a cross over style RCT(randomised control trial) will be utilised which means that the control group will at a predetermined time convert to using the technology solution while the intervention group will at this same point in time then revert to the traditional solution. This strategy is deemed appropriate in studies of this nature so that it is possible for patients to compare with \/without technology scenarios. \n \nEstablished qualitative and quantitative techniques will be employed to analyse the collected data. Specifically, from the qualitative data, thematic analysis will be performed in accordance with standard approaches described by Boyatzis and Kvale, while regression techniques and exploratory data mining techniques will for the major focus for the quantitative part. \n \nResults: The results to date of this research in progress include the establishment of the appropriate delivery framework and web-based conceptual model. A key aspect of this conceptual model is that it emphasises sustainability and long term support for patients. Given the nature of diabetes this is an important aspect. \n \nConclusions: Based on the success and findings of using a pervasive technology solution to support diabetes self-care in both Canada and US, we have attempted to adapt such a solution into the Australian context. Like all countries today, Australia also has an increasing number of individuals diagnosed with diabetes and this statistic is predicted to grow exponentially in the next decades which in turn places a significant on patients, their families, the community and the healthcare system. We have chosen to initially focus on patients suffering with GDM as this segment of the population is technology savvy and therefore should embrace a technology support solution readily. The next step is to now run the pilot studies. While clinically, no major differences exist in the treatment of GDM in North America and Australia, given fundamental differences in the respective healthcare systems i.e., Australia has a two-tier healthcare system, demonstrating the benefits of this solution in an Australian healthcare context will serve to underscore the true pervasiveness of this solution. []","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":69050776,"openaccessinfo":{"externalids":{"MAG":"992074122","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effect of arachidonic acid (C20:4) on the production of secretory type II phospholipase A2 (sPLA2-II) by guinea-pig alveolar macrophages was investigated. We show that incubation of these cells with 1-30 microM of arachidonic acid inhibits the synthesis of sPLA2-II in a concentration-dependent manner with an IC50 of approximately 7.5 microM. The inhibition by low concentrations (5 microM) of arachidonic acid was partially reduced by pretreatment of alveolar macrophages with cyclooxygenase or cytochrome P450 inhibitors (aspirin and 1-aminobenzotriazole, respectively), but not by lipoxygenase inhibitor, BW A4C. However, these inhibitors failed to interfere with the effect of high concentrations (30 microM) of arachidonic acid, suggesting that the latter may act on the expression of sPLA2-II, at least in part, independently of eicosanoid generation. Indeed, a similar inhibitory effect on sPLA2-II activity and mRNA expression was observed with other unsaturated fatty acids such as eicosapentaenoic (C20:5) and oleic (C18:1) acids, but not with the saturated fatty acid, palmitic acid (C16:0). In addition, arachidonic acid partially reduced the secretion of tumor necrosis factor alpha, an important intermediate in the induction of sPLA2-II synthesis by guinea-pig alveolar macrophages. However, addition of recombinant tumor necrosis factor alpha failed to reverse the inhibitory effect of arachidonic acid on sPLA2-II expression, suggesting that this process occurs downstream of tumor necrosis factor alpha secretion. We conclude that the expression of sPLA2-II in alveolar macrophages is down-regulated at the transcriptional level by arachidonic acid either directly or via its cyclooxygenase and cytochrome P450-derived metabolites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37046142,"openaccessinfo":{"externalids":{"MAG":"1895893051","ACL":null,"DOI":"10.1046\/J.1432-1327.2000.01392.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Antibiotics are powerful drugs to prevent and treat perinatal infections. Overuse of antibiotics leads to antibiotic resistance, has potential side e ff ects and influences the maternal","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261275719,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A Catholic nurse in New York City is suing her hospital over allegations that she was forced to assist in an abortion; a Chicago-area facility has begun a nurse-led \"laughter therapy\" program for its disabled and mentally ill patients; nursing organizations are protesting the indictment of two Texas nurse whistleblowers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208211344,"openaccessinfo":{"externalids":{"MAG":"1735891133","ACL":null,"DOI":"10.1177\/216507998002801209","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Synthetic-based drilling fluids (SBF) have been used in a variety of drilling applications and are an important component of deepwater drilling operations. One of the applications of SBF is high-temperature wells. In order to address regulatory concerns about SBF in high temperature applications, an inter-industry study was conducted to examine the effects of temperature and time on the sediment toxicity (to Leptocheirus plumulosus) of synthetic-based fluids used for high-temperature wells. Four factors were examined: (1) ester content, (2) time, (3) temperature, and (4) alkalinity (absence or presence of green cement). Three base-stock fluids were tested, a 100% internal olefin (C1618 IO) and two traditional ester\/olefin blends (10%\/90% and 30%\/70%). The base fluids were blended into drilling fluids and subjected to temperatures ranging from 275 to 350\u00b0F and time of exposures to temperature ranging from 16 to 160 hr. Phase 1 toxicity results indicated that temperature and time parameters bracketed the region where ester\/olefin drilling fluids transitioned from passing to failing the sediment toxicity limitation. Phase 2 used a statistical experimental design to identify significant factors impacting toxicity, and a statistical model was developed to predict sediment toxicity ratios (STR). 2-Ethyl hexanol, an indicator of ester hydrolysis, was positively correlated with increased STR and could be used to screen for potential sediment toxicity. The sediment toxicity tests, analytical measurements, and the statistical STR model supported the hypothesis that, for the types of muds studied, toxicity increased for ester\/olefin blends under downhole conditions of increased time and temperature. The data from this study support caution in the use of drilling fluids containing the type of esters (traditional esters) used in this study when temperatures exceed a threshold of ~300\u00b0F. Above 300\u00b0F, these materials may break down and result in increased sediment toxicity for the drilling fluids.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":137142304,"openaccessinfo":{"externalids":{"MAG":"2033019532","ACL":null,"DOI":"10.2118\/94429-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim was to evaluate the effects of previous treatments in the Arachis pintoi Krapov. & W. C. Greg. seeds germination and vigour. A completely randomized design with four replication arranged in a factorial scheme (2 lots x 7 treatments), was used. For this, two commercial lots of seeds with intact pods of Arachis pintoi, cv. Amarillo, stored by six and 12 months, were used. In each lot, the treatments were employed through pod removal or not, the pod breakage and the exposition of intact pods at 45oC for 48 and 72 hours and to the hidratation for 24 and 48 hours. Further, for treatment, it was performed the evaluation of water content, germination and vigor (first count of germination and seedling emergency). The pod removal became the seeds vulnerable to the action of microorganism. Heating at 45oC for 48 and 72 hours caused reduction of the nom-germinated seeds. The hidratation for 48 hours favored the Arachis pintoi seed germination and vigour.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":83487359,"openaccessinfo":{"externalids":{"MAG":"1993567496","ACL":null,"DOI":"10.1590\/S1413-70542008000100025","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to determine which patient- or surgery-related factors are predictive of need for perioperative transfusion to avoid obtaining unnecessary pre-operative type and screens (T&S). We conducted an observational retrospective cohort study of 1200 women \u2265 18 years old undergoing gynecologic surgery for benign, possibly benign, or malignant indications on a gynecologic oncology service at a university medical center from 2009-2016. A logistic regression model was used to examine patient-related and surgery-related variables predictive of outcome of transfusion. Independent variables included patient demographics, comorbidities, and surgical indication surgical route, and surgical type. Dependent variable was transfusion outcome (T&S only, conversion to type and cross (T&C), or transfusion). Eight hundred ninety-nine (74.9%) women underwent pre-operative T&S, of which 118 (9.8%) were converted to T&C, and 80 (6.7%) received a transfusion of blood or blood products. Cancer indication, major surgery, and preoperative hematocrit less than 36% were significantly associated with need for transfusion (P = 0.002, P < 0.0001, P < 0.0001, respectively). Patients with a benign indication undergoing minor procedures and with normal preoperative hematocrit are least likely to require transfusion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233940078,"openaccessinfo":{"externalids":{"MAG":"3127827100","ACL":null,"DOI":"10.31083\/j.ceog.2021.01.2152","PubMedCentral":"8301211","ArXiv":null},"license":"CCBY","url":"https:\/\/www.imrpress.com\/journal\/CEOG\/48\/1\/10.31083\/j.ceog.2021.01.2152\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Guzman JF, Calpe-Gomez V. Preliminary study of coach verbal behaviour according to game actions. J. Hum. Sport Exerc. Vol. 7, No. 2, pp. 376-382, 2012. The aim of this study was to analyse the interaction between game actions in high-level handball and verbal behaviour performed by the coach. For this purpose, a match of the 1 st National Division of male Spanish handball was analysed. The type of behaviour and the content of the message reported by the coach were recorded using a modified version of Coaching Behaviour Assessment System (CBAS) and Coach Analysis and Intervention System (CAIS). About game actions, they were grouped into positive and negative. Statistically significant differences were obtained in both the coach's type of behaviour (Chi-square = 63.978, df = 13, Sig <0.001) and message content (Chi-square = 19.401, df = 6, Sig = 0.004) according the game action performed previously (positive or negative). After positive actions coach performed more positive feedback and encouragement, and after negative actions coach performed more negative feedback and queries, and content of communication was more related with results of technical-tactical action. Results offer some clues about specific coach behaviours that may be game action dependent. This knowledge may be useful to implement interventions to improve coaches' behaviour. However, more in depth studies with bigger samples are necessary. Key words: COACHING BEHAVIOUR, FEEDBACK, COMMUNICATION PATTERNS, NOTATIONAL ANALYSIS","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-20":1,"2013-48":1}},"corpusid":143586889,"openaccessinfo":{"externalids":{"MAG":"2002833156","ACL":null,"DOI":"10.4100\/JHSE.2012.72.04","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Northern Hemisphere (NH) blocking climatology is examined using a subset of climate models participating in the Coupled Model Intercomparison Project phase 5 (CMIP5). Both historical and Representative Concentration Pathway (RCP) 8.5 integrations are analyzed to evaluate the performance of the CMIP5 models and to identify possible changes in NH blocking frequency and duration in a warmer climate. Comparison with reanalysis data reveals that CMIP5 models can reproduce the NH blocking climatology reasonably well, although the frequency of Euro\u2010Atlantic blockings, particularly those with relatively short duration, is significantly underestimated during the cold season. In most models, overestimation of the Pacific blocking frequency is also evident for all durations throughout the year. In comparison to historical integrations, RCP 8.5 integrations show significant decreases in blocking frequency over both the North Pacific and north Atlantic regions, with a hint of increasing blocking frequency over western Russia. However, there is no noticeable change in the duration of individual blocking events for all durations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1,"unknown":2}},"corpusid":55881082,"openaccessinfo":{"externalids":{"MAG":"1494716491","ACL":null,"DOI":"10.1002\/jgrd.50143","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/agupubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgrd.50143","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The use of physical methods of processing, in particular ultraviolet radiation, is used in the food industry for the purpose of disinfection of raw materials, semi-finished products and finished products, which increases the storage time. The process of processing food products with ultraviolet light quickly proved itself. This method does not change the taste of the product, increases the shelf life and sales, and is a non-thermal method of deactivating pathogens. The wide use of the bactericidal effect of UV rays for food products is limited by their low penetration capacity, so the UV spectrum can be used mainly for sur-face sterilization, provided that the deep layers of the material do not contain microflora. The effectiveness of UV radiation depends on the following factors: the source and the UV dose; the sensitivity of microorganisms to UV light; the composition and physical properties of the product. Object of research: model media containing native microflora of dried fruit raw materials \"dried Apri-cots\". The research was carried out using model media simulating the proper-ties of the raw material surface, excluding its protective mechanisms and allow-ing to reveal the true dynamics of inhibition of native microflora. Native micro-flora of dried fruits implies a set of microorganisms. Literature sources have shown the possibility of the presence of such types of microorganisms as E. coli, Salmonella, Candida, Pseudomonas, spore forms of microorganisms on the surface of raw materials. During the experiment it was determined that the treatment duration of 5 min reduced the initial contamination of 2 order pro-cessing in 10 minutes \u2013 2.6 the order in 15 minutes \u2013 2.7 order and 20 minutes for 3 orders of magnitude.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":241546591,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.20914\/2310-1202-2020-4-122-125","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.vestnik-vsuet.ru\/vguit\/article\/download\/2583\/3719","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The optical crosstalk between lasers in densely-packed multiple-wavelength vertical-cavity photonic integrated emitter arrays is studied for multimode wavelength-division multiplexing applications. It is found that a significant number of photocarriers are generated by spontaneous emission of an adjacent laser. However, an appropriate prebiasing scheme or device design can reduce the crosstalk to < \u201320 dB.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":109912638,"openaccessinfo":{"externalids":{"MAG":"1997146770","ACL":null,"DOI":"10.1049\/EL:19980498","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Long\u2010term exposure of native vegetation to elevated atmospheric carbon dioxide (CO2) is expected to increase the water content and the input of labile carbon (C) to soil, which could stimulate nitrification and denitrification and enhance nitrous oxide (N2O) emissions. We measured N2O fluxes for 2 years in a Pinus taeda forest that was continuously enriched 200 \u03bcL L\u22121 CO2 above the ambient atmospheric CO2 concentration (\u223c560 \u03bcL L\u22121) beginning 16 months prior to our study. Soil treated with elevated CO2 showed higher N2O emissions at low winter temperatures than the ambient CO2 control. Conversely, soil treated with elevated CO2 showed lower N2O emissions at high summer temperatures than the control soil. Annual N2O fluxes, however, were similar between treatments (\u223c6600 \u03bcg m\u22122). Factors that influence denitrification and N2O production were investigated in the laboratory using intact soil core incubations. Nitrate additions (0.17 mg KNO3\u2212N g\u22121 ) to intact soil cores during laboratory incubations stimulated total N2O production as well as denitrification in both treatments, whereas glucose additions lowered N2O production in both treatments. These experiments demonstrated that N2O production is strongly limited by available nitrogen (N) and that the addition of labile C is likely to reduce the amount of N2O produced by nitrification. Our results collectively suggest that CO2 enrichment of this N\u2010limited ecosystem may reduce N2O flux during the growing season, when soil C inputs and plant\u2010microbial competition for NH4+ are high. Alternatively, elevated CO2 may enhance N2O flux in the winter, when conditions are moist and cold and plants are less active. The potential indirect effects of CO2 enrichment (greater soil moisture and labile C inputs) could reduce N2O flux from nitrification in summer and enhance N2O flux from denitrification in winter, resulting in no net change in total ecosystem N2O flux at the soil\u2010atmosphere interface.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129377685,"openaccessinfo":{"externalids":{"MAG":"2021578427","ACL":null,"DOI":"10.1029\/2000GB001372","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"I read with interest your piece about Unison's campaign to outlaw nurse's rights to belong to the BNP (news April 29) I suggest they go one step further and implement a ban on Conservative party members.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19628285,"openaccessinfo":{"externalids":{"MAG":"2509924613","ACL":null,"DOI":"10.7748\/ns.23.38.33.s38","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Nowadays, information technologies play an important role in education. In education, mobile and TV applications can be considered a support tool in the teaching learning process, however, relevant and appropriate mobile and TV applications are not always available; teachers can only judge applications by reviews or anecdotes instead of testing them. These reasons lead to the needs and benefits for creating one's own mobile application for teaching and learning. In this work, we present a cloud-based platform for multi-device educational software generation (smartphones, tablets, Web, Android-based TV boxes, and smart TV devices) called AthenaCloud. It is important to mention that an open cloud-based platform allows teachers to create their own multi-device software by using a personal computer with Internet access. The goal of this platform is to provide a software tool to help educators upload their electronic contents \u2013 or use existing contents in an open repository \u2013 and package them in the desired setup file for one of the supported devices and operating systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":11390824,"openaccessinfo":{"externalids":{"MAG":"2556342689","ACL":null,"DOI":"10.2298\/CSIS160807037V","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As a benchmark to assess the performance of the control loops, minimum variance (MV) has been widely used in industrial process. MV control gives the lowest achievable output variance when there is no constraint on the actuator. In this paper, it shows that MV controller is no longer optimal and the mean of the output value is non-zero when the constraint is active and the parameter of the disturbance is approaching to one. In order to achieve the lowest variance of the output value, and the mean of the output can be approaching to zero, a new approach is proposed in this paper. The proposed method is imposing a compensation value on the constrained MV control law, meanwhile, a new performance index function is introduced. As a result, it is believed that this method is more effective to the real industrial process for systems with actuator constraints and stochastic disturbances. Simulation example demonstrates the usefulness of this method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110870172,"openaccessinfo":{"externalids":{"MAG":"2228715670","ACL":null,"DOI":"10.1109\/ICCECT.2013.152","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Response-cost procedures within a token economy with extremely regressed residents excluded many residents from access to positive reinforcement. Procedures allowing residents to \"purchase eligibility\" to obtain backup reinforcers through contingent payment on standing fines, combined with proportional fine payoff schedules contingent upon time without new fines, increased payment on fines, reduced incidence of new fines, and increased utilization of backup reinforcers. These modifications removed adverse side effects while retaining the benefits associated with response costs. Failures or adverse effects of elements of token systems should not occasion abandonment of token economies, but rather encourage their continual evaluation and modification.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38785312,"openaccessinfo":{"externalids":{"MAG":"2026870440","ACL":null,"DOI":"10.1901\/JABA.1974.7-191","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gridiron Gang is a film of true story about the football team as a solution to the \nproblems that always occur and is not resolved at the Kilpatrick Prison Center and \nFootball team consisting of teenagers with criminal backgrounds. The main character in \nthe film is Sean Porter who initiated the soccer team formation program. This case is \nimportant to discuss because criminal actions must be overcome by means of \nrehabilitation and healthy treatment of teenage.The aims of this research are : (1) To find \nout kinds Sean Porter\"s personality as seen in the film Gridiron Gang by Phil Joanou. \n(2)To find out the problems faced by Sean Porter in the film Gridiron Gang by Phil \nJoanou. (3) To find out the Sean Porter solves the problems in the film Gridiron Gang by \nPhil Joanou. \nThis research uses descriptive method and Qualitative research is Personality \ntheory by Hippocrates (1971). Documentation technique is used for collecting the data \nand descriptive analysis technique for analyzing the data. The research found that: (1) the \npersonality of the main characters, that areCholoric, Melancholis and Plegmatic. Choloric \nis the ability in the leadership of the football team and can solve the problems faced by \ncriminal children from different backgrounds. Melancholic is having a strong will to help \nthe problems faced by criminal children, firm and always motivating children. Plegmatic \nis to improve the atmosphere with a good style of humor and socializing with others. \nThe problems faced by the main characters are revenge and rampant murder \nbecause they are influenced by different backgrounds. and Making decisions is the right \nways to solve problems in Gridiron Gang film, fulfill needs such as making a football \nteam, completing equipment and providing support for criminal children for a better life.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":217063613,"openaccessinfo":{"externalids":{"MAG":"3016196721","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dipeptidyl peptidase-IV (DPP-IV) is an enzyme present in the saliva, and its interaction with satiety related hormones is poorly understood. The purpose of this study was to determine possible relationships between salivary DPP-IV activity and body composition. Further, the response of salivary DPP-IV activity to carbohydrates was investigated. We tested 111 people for plasma and saliva DPP-IV activity using a fluorometric assay and Neuropeptide Y 1-36 (NPY) protein using an EIA. Body composition was determined via a DEXA scan. Relationships were determined using regression analysis. In the second part, we tested 28 people on four separate occasions, where the participants either swished and spit or ingested a commercially available sucrose or aspartame sweetened beverage. Saliva and plasma were collected before and after each condition and were processed as described above. Blood glucose was also measured. No relationship was found between salivary DPP-IV activity or NPY 1-36 and any body composition measurement. For Part 2, no change in plasma DPP-IV occurred with any of the conditions, despite an increase in blood glucose with the sucrose-beverage ingestion condition (p<0.05). However, salivary DPP-IV activity was attenuated with all conditions, except aspartame-beverage swish and spit. Salivary NPY 1-36 was not altered by the conditions. The unique finding from this study was that salivary DPP-IV activity was attenuated with sucrose or aspartame beverage, but plasma DPP-IV was unchanged. This result implies that satiety may be reduced when drinking sucrose or aspartame beverages.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":99499581,"openaccessinfo":{"externalids":{"MAG":"2612579511","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Treatment of Zollinger-Ellison syndrome with cimetidine is justified by prior pharmacological studies; close survey of the patients is necessary, using clinical (endoscopic control of ulcer; diarrhea) and biological (BOA measurements and assessment of cimetidine efficiency) criteria. On the basis of 7 patients suffering from of chronic forms of ZES treated with cimetidine for periods varying from 56 to 570 days, a therapeutic scheme is suggested, allowing individual choices in the following problems:-possibility of gastrinoma complete excision, -advantages and disadvantages of cimetidine vs. total gastrectomy in respect to side-effects and acid secretion suppression, -variations in drug efficacy according to time (prolonged secretory inhibition, escape phenomenon).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25118638,"openaccessinfo":{"externalids":{"MAG":"2417776822","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It has often been pointed out that the Bragg backscatter of radar waves from elevated turbulent layers is very highly correlated with the height gradient of radio refractive index (RI) through these layers. However, many users need the profiles of RI, or the associated humidity, rather than profiles of their gradients. Simple integration of the gradients is usually not feasible because of ground or sea clutter and because biological scatterers such as insects and birds often severely contaminate the lower range gates. We show that if the total height\u2010integrated RI is independently available (say, from the Global Positioning System (GPS)), and if the surface value of RI is known, the profiles of RI are retrievable with good accuracy. For those profiler systems equipped with a radio acoustic sounding system to measure temperature, the humidity is also retrievable. The method is demonstrated with data collected in southern California, where 7 hours of profiler data were recorded at 449 MHZ along with GPS data. Three radiosonde balloons were launched during the period, and the profiles of RI from the balloon and the profiler are compared. The advantages of the system are its invulnerability to nonprecipitating clouds (at frequencies of 449 MHZ or lower) and that it uses only facilities that will soon be deployed globally. Simulations are used to assess errors from various factors such as loss of sign of the gradient of the potential RI (important especially during some frontal events) and the presence of biological contaminants in some geographical areas (such as coastal zones and some agricultural areas at night).","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":119451946,"openaccessinfo":{"externalids":{"MAG":"2007574077","ACL":null,"DOI":"10.1029\/1998RS900029","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nevaluate the impact of Health Authorities' communication on medical practices through 2 examples: celecoxib, taking into account the recent countra indication related to cardio vascular risks; pergolide, taking into account the risk of cardiac valvulopathy.\n\n\nMATERIAL AND METHOD\nUse of the Pays de Loire Health Insurance Administration data base to monitor the number of cardio vascular patients at risk who receive celecoxib, and cardiac surveillance of pergolide exposed patients.\n\n\nRESULTS\nCommunication from Health Authorities resulted in a major decrease (71.9%) of the number of risking patients who take celecoxib, and a significant 14% decrease of pergolide treated patients needing cardiac monitoring\n\n\nCONCLUSION\nUnlike the information related to pergolide, the information related to celecoxib was fully taken into account. The difference seems to come from the fact that one was widely relayed by medias, not the other.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45241806,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2515\/therapie:2007064","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We describe the clinical data, the standard and Holter electrocardiographic observations, the carotid pulse tracings, the M-mode and B-mode echocardiographic findings and the left ventriculographic aspects of 21 patients with non-obstructive symmetric hypertrophic cardiomyopathy (NOSHCM). NOSHCM was diagnosed when there was echocardiographic and\/or left ventriculographic evidence of septal and posterior wall hypertrophy without signs of left ventricular outflow destruction (LVOTO). Compared to the asymmetric hypertrophic obstructive cardiomyopathy (AHOCM), NOSHCM reveals reduced excursion of the posterior wall of the left ventricle, whereas patients with AHOCM have more frequently systolic murmurs and carotid pulse changes suggestive of LVOTO. Proper classification and treatment of NOSHCM are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37442806,"openaccessinfo":{"externalids":{"MAG":"2398726548","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The conservative techniques of treating knee osteoarthritis (kOA) include wearing orthoses such as knee braces and laterally wedged insoles and applying gait modification techniques such as toe-in gait and toe-out gait. This study aimed at assessing the immediate effects of these techniques in improving physical function of healthy and kOA participants. Five Osteoarthritis Research Society International (OARSI) recommended performance-based tests were randomly applied to measure physical function: (1) 30-second chair stand test (30CST), (2) 40-m (4 \u00d7 10) fast-paced walk test (40FPW), (3) stair climb test (SCT), (4) timed up and go test (TUGT) and (5) 6-minute walk test (6MWT) during a single-visit on 20 healthy and 20 kOA patients (age: 59.5 \u00b1 7.33 and 61.5 \u00b1 8.63 years, BMI: 69.95 \u00b1 9.86 and 70.45 \u00b1 8.80 kg\/m2). The interventions included natural gait, toe-out gait, toe-in gait, laterally wedged insoles and knee brace. Analysis was performed through repeated-measures ANOVA and independent sample t-test. 30CST and TUGT showed no significant differences for the five test conditions (p > 0.05). Toe-out showed profound effects via pairwise comparison in impairing the physical function while knee brace improved it during 40FPW, SCT and 6MWT. In general, all the tested conservative techniques except laterally wedged insoles had immediate effects on physical performance measures in both healthy and medial knee osteoarthritis participants. The valgus knee brace improved the parameters the most, while toe-out gait impaired them the most. Future studies can develop strategies for improving gait retraining methods on the basis of issues identified by this study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":218910776,"openaccessinfo":{"externalids":{"MAG":"3031569607","ACL":null,"DOI":"10.1177\/0954411920924525","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A procedure is described that uses a small collimator in the center of the Eulerian cradle for the alignment of the incident beam, the zero positions of the circles and the collimators of a four-circle diffractometer. The method is applicable also with a large initial misalignment of the diffractometer. The results obtained indicate a high reproducibility of the zero-position values, with deviations of the order of the step accuracy of the angle setting.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123789747,"openaccessinfo":{"externalids":{"MAG":"2185407643","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present here a framework for modifying a decoder for parallel concatenated codes to incorporate a general hidden Markov source model. This allows the receiver to utilize the statistical characteristics of the source during the decoding process, and leads to significantly improved performance relative to systems in which source statistics are not exploited. One of the constituent decoders makes use of a modified trellis which jointly describes the source and the encoder. The number of states in this modified trellis is the product of the number of states in the hidden Markov source and the number of states in the encoder.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":17922675,"openaccessinfo":{"externalids":{"MAG":"2169946309","ACL":null,"DOI":"10.1109\/4234.602600","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Previous in vitro selection experiments identified an RNA aptamer that recognizes the chromophore malachite green (MG) with a high level of affinity, and which undergoes site-specific cleavage following laser irradiation. To understand the mechanism by which this RNA folds to recognize specifically its ligand and the structural basis for chromophore-assisted laser inactivation, we have determined the 2.8 A crystal structure of the aptamer bound to tetramethylrosamine (TMR), a high-affinity MG analog. The ligand-binding site is defined by an asymmetric internal loop, flanked by a pair of helices. A U-turn and several non-canonical base interactions stabilize the folding of loop nucleotides around the TMR. The aptamer utilizes several tiers of stacked nucleotides arranged in pairs, triples, and a novel base quadruple to effectively encapsulate the ligand. Even in the absence of specific stabilizing hydrogen bonds, discrimination between related fluorophores and chromophores is possible due to tight packing in the RNA binding pocket, which severely limits the size and shape of recognized ligands. The site of laser-induced cleavage lies relatively far from the bound TMR ( approximately 15 A). The unusual backbone conformation of the cleavage site nucleotide and its high level of solvent accessibility may combine to allow preferential reaction with freely diffusing hydroxyl radicals generated at the bound ligand. Several observations, however, favor alternative mechanisms for cleavage, such as conformational changes in the aptamer or long-range electron transfer between the bound ligand and the cleavage site nucleotide.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36656283,"openaccessinfo":{"externalids":{"MAG":"2131457029","ACL":null,"DOI":"10.1006\/JMBI.2000.3951","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Adiposity is central to aging and several chronic diseases. Adiposity encompasses not just the excess adipose tissue but also body fat redistribution, fat infiltration, hypertrophy of adipocytes, and the shifting of mesenchymal stem cell commitment to adipogenesis. Bone marrow adipose tissue expansion, inflammatory adipokines, and adipocyte-derived extracellular vesicles are central to the development of osteopenic adiposity. Adipose tissue infiltration and local adipogenesis within the muscle are critical in developing sarcopenic adiposity and subsequent poorer functional outcomes. Ultimately, osteosarcopenic adiposity syndrome is the result of all the processes noted above: fat infiltration and adipocyte expansion and redistribution within the bone, muscle, and adipose tissues, resulting in bone loss, muscle mass\/strength loss, deteriorated adipose tissue, and subsequent functional decline. Increased fat tissue, typically referred to as obesity and expressed by body mass index (the latter often used inadequately), is now occurring in younger age groups, suggesting people will live longer with the negative effects of adiposity. This review discusses the role of adiposity in the deterioration of bone and muscle, as well as adipose tissue itself. It reveals how considering and including adiposity in the definition and diagnosis of osteopenic adiposity, sarcopenic adiposity, and osteosarcopenic adiposity will help in better understanding the pathophysiology of each and accelerate possible therapies and prevention approaches for both relatively healthy individuals or those with chronic disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263766223,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/metabo13101056","PubMedCentral":"10608812","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2218-1989\/13\/10\/1056\/pdf?version=1696679974","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Degloving injuries are uncommon but serious and are being encountered with increasing frequency in children. A 5-year review of experience with degloving injuries on the Orthopaedic Service at the Winnipeg (Manitoba, Canada) Children's Hospital revealed 16 patients who had sustained this trauma in association with fractures. Twelve of these children had typical anatomical degloving. However, six patients had an associated concealed degloving or so-called \"physiological degloving,\" with disruption of the underlying skin vasculature but no actual disruption of the skin surface. The most common causes of degloving injuries were being run over by a motor vehicle and farm machinery accidents. The diagnosis and proper management of the de-gloved extremity, especially when accompanied by underlying fracture, are essential in children if morbidity and limb loss are to be minimized.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22265153,"openaccessinfo":{"externalids":{"MAG":"2163885038","ACL":null,"DOI":"10.1097\/01241398-198603000-00014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nDehydration has been underappreciated as a cause of hospitalization and increased hospital-associated mortality in older people. This study used national data to analyze the burden and outcomes following hospitalizations with dehydration in the elderly.\n\n\nMETHODS\nData from 1991 Medicare files were used to calculate rates of hospitalization with dehydration, to examine demographic characteristics and concomitant diagnoses associated with dehydration, and to analyze the contribution of dehydration to mortality.\n\n\nRESULTS\nIn 1991, 6.7% (731,695) of Medicare hospitalizations had dehydration listed as one of the five reported diagnoses, a rate of 236.2\/10,000 elderly Medicare beneficiaries. In 1991, Medicare reimbursed over $446 million for hospitalizations with dehydration as the principal diagnosis. Older people, men, and Blacks had elevated risks for hospitalization with dehydration. Acute infections, such as pneumonia and urinary tract infections, were frequent concomitant diagnoses. About 50% of elderly Medicare beneficiaries hospitalized with dehydration died within a year of admission.\n\n\nCONCLUSIONS\nHospitalization of elderly people with dehydration is a serious and costly medical problem. Attention should be focused on understanding predisposing factors and devising strategies for prevention.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":22140553,"openaccessinfo":{"externalids":{"MAG":"2099296845","ACL":null,"DOI":"10.2105\/AJPH.84.8.1265","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Adaptive approaches, allowing for more flexible trial design, have been proposed for individually randomized trials to save time or reduce sample size. However, adaptive designs for cluster-randomized trials in which groups of participants rather than individuals are randomized to treatment arms are less common. Motivated by a cluster-randomized trial designed to assess the effectiveness of a machine-learning based clinical decision support system for physicians treating patients with depression, two Bayesian adaptive designs for cluster-randomized trials are proposed to allow for early stopping for efficacy at pre-planned interim analyses. The difference between the two designs lies in the way that participants are sequentially recruited. Given a maximum number of clusters as well as maximum cluster size allowed in the trial, one design sequentially recruits clusters with the given maximum cluster size, while the other recruits all clusters at the beginning of the trial but sequentially enrolls individual participants until the trial is stopped early for efficacy or the final analysis has been reached. The design operating characteristics are explored via simulations for a variety of scenarios and two outcome types for the two designs. The simulation results show that for different outcomes the design choice may be different. We make recommendations for designs of Bayesian adaptive cluster-randomized trial based on the simulation results.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":245827733,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2201.02301"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One of the genres which has been neglected by the Academy Award is the metacinema, which for practical purposes I will consider to be a cross between the complexities of self-reflexive cinema (highly connoted with modernism) and the Hollywood Film (the classical films about the urge to \"make it\" in Hollywood). Indeed, these films have always existed and some, as Sunset Boulevard (Billy Wilder, 1950, USA) and Mulholland Dr. (David Lynch, 2001, FRA\/USA), have even made it to the ceremony, but were, predictably, defeated by other more serious or less reflexive products in the main categories. The United States has always insisted on not revealing the tricks of the trade at the same time that made films about it to cater to the curiosity of the cinema-inclined spectator. For this reason these films are usually about the universe of cinema but not its medium, at least not in a way that discloses the operations of the technical apparatus. Why are these films not viewed as serious enough and artistic enough to be awarded\u00a0\u00a0 Oscars by the Academy in the categories of Best Film, Best Director, Best Screenplay, and Best Cinematography? Are they being discarded for the same reasons that comedy and musicals usually are? Or are they being punished for being too unveiling? Or is the industry going for commercial products that can easily pushed on a global scale and make a profit?","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":141983919,"openaccessinfo":{"externalids":{"MAG":"565311267","ACL":null,"DOI":"10.31165\/NK.2014.74.353","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The reaction between B(2)(NMe(2))(4) and 1,2-(NH(2))(2)-4-Bu(t)C(6)H(3) affords the diborane(4) compound 1,2-B(2){1,2-(NH)(2)-4-Bu(t)C(6)H(3)}(2) as the exclusive product whilst the reaction between rac-1,2-(NH(2))(2)C(6)H(10) and B(2)(NMe(2))(4) also affords only the 1,2-isomer, i.e. 1,2-B(2){1,2-(NH)(2)C(6)H(10)}(2), which is shown to be the more stable isomer by computational methods. The previously reported compounds 1,1-B(2){1,2-(NH)(2)C(6)H(4)}(2) and 1,2-B(2){1,2-(NH)(2)C(6)H(4)}(2) both react with four equivalents of Bu(n)Li to give what are presumed to be tetra-anions which react further with MeI, SnClMe(3) or SnClPh(3) to give the tetrasubstituted products 1,1-B(2){1,2-(NMe)(2)C(6)H(4)}(2), 1,1-B(2){1,2-(NSnMe(3))(2)C(6)H(4)}(2) and 1,2-B(2){1,2-(NSnPh(3))(2)C(6)H(4)}(2) respectively. The compound 1,1-B(2){1,8-(NH)(2)C(10)H(6)}(2) has also been prepared from the reaction between B(2)(NMe(2))(4) and 1,8-diaminonaphthalene. Lithiation and subsequent reaction with SnClMe(3), SnCl(2)Me(2) or SnCl(2)Ph(2) affords 1,1-B(2){1,8-(NSnMe(3))(2)C(10)H(6)}(2), 1,1-B(2){1,8-(N(2)-\u03bc-SnMe(2))C(10)H(6)}(2) and 1,1-B(2){1,8-(N(2)-\u03bc-SnPh(2))C(10)H(6)}(2) respectively. All new compounds have been characterised by X-ray crystallography.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23133034,"openaccessinfo":{"externalids":{"MAG":"2005852417","ACL":null,"DOI":"10.1039\/c2dt11936f","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The overgrowing population and the recent droughts are putting water resources under pressure and calling for new approaches for water planning and management if escalating con#icts are to be avoided and environmental degradation is to be reversed. As countries are using their water resources with growing intensity, poor rainfall increasingly leads to national water crises as water tables fall and reservoirs, wetlands and rivers empty. Global warming could cause further changes, further variability and further uncertainty. The UK Hadley Centre's global climate model was run at a spatial scale of 2)5 by 3)753 (latitude and longitude) grid squares to simulate the global climate according to scenarios of greenhouse gas concentration emission. Runs of the model assuming the emission scenario proposed by the Intergovernmental Panel on Climate Change in 1995 are analysed here for the 2050s time horizon. Outputs provide estimations of climate variables, such as precipitation and temperature, at a monthly time step. Those results, assumed representative of future climatic conditions, are compared to mean monthly values representative of the current climate and expressed in terms of percentage change. The results show that, for the dry season (April}September), by the 2050s, North Africa and some parts of Egypt, Saudi Arabia, Iran, Syria, Jordan and Israel, are expected to have reduced rainfall amounts of 20}25% less than the present mean values. This decrease in rainfall is accompanied by a temperature rise in those areas of between 2 and 2)753C. For the same period, the temperature in the coastal areas of the Mediterranean countries will rise by about 1)53C. In wintertime, the rainfall will decrease by about 10}15% but would increase over the Sahara by about 25%. Given the low rainfall rate over the Sahara, the increase by 25% will not bring any signi\"cant amount of rain to the region. In wintertime, the temperature in the coastal areas will also increase but by only 1)53C on average, while inside the region it will increase by 1)75}2)53C. In southern Africa (Angola, Namibia, Mozambique, Zimbabwe, Zambia, Botswana and South Africa), results suggest an increase of the annual average temperature ranging between 1)5 and 2)53C in the south to between 2)5 and 33C in the north. The summer range is between 1)75 and 2)253C in the south, and increases towards the north to between 2)75 and 3)03C while the winter range is between 1)25 and 23C in the south, and increases towards the north to between 2)5 and 2)753C. On the other hand, the annual average will decrease by 10}15% in the south and by 5}10% in the north. The annual average decrease is 10%. However, some places will have an increase i.e. by 5}20% in South Africa in wintertime. In the Taklimakan region (Tarim Basin) west of China, the annual average temperature is shown to increase by 1)75}2)53C. Annual average rainfall should increase by 5}'25% in most of the region but decrease by 5}10% in some small parts. In summer, an increase by 5}15% is indicated in most of the region, and an increase by up to 25% or more during the wintertime. In the Thar Desert (India}Pakistan}Afghanistan), estimations suggest that the annual average increase in temperature ranges from 1)75 to 2)53C, ranging from 1)5 to 2)253C in winter and from 2 to 2)53C in summer. Annual average precipitation is shown to decrease by 5}25% in the region. The winter will have values closer to the annual average but the summer will have more decrease and most of the region will see a decrease closer to 25%.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":54194782,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The neutron capture cross section of 209Bi has been measured at the CERN n TOF facility by employing \nthe pulse-height-weighting technique. Improvements over previous measurements are mainly because of an \noptimized detection system, which led to a practically negligible neutron sensitivity. Additional experimental \nsources of systematic error, such as the electronic threshold in the detectors, summing of \u03b3 -rays, internal electron \nconversion, and the isomeric state in bismuth, have been taken into account. \u03b3 -Ray absorption effects inside the \nsample have been corrected by employing a nonpolynomial weighting function. Because 209Bi is the last stable \nisotope in the reaction path of the stellar s-process, theMaxwellian averaged capture cross section is important for \nthe recycling of the reaction flow by \u03b1 decays. In the relevant stellar range of thermal energies between kT = 5 \nand 8 keV our new capture rate is about 16% higher than the presently accepted value used for nucleosynthesis \ncalculations. At this low temperature an important part of the heavy Pb-Bi isotopes are supposed to be synthesized \nby the s-process in the He shells of low mass, thermally pulsing asymptotic giant branch stars.With the improved \nset of cross sections we obtain an s-process fraction of 19\u00b13% of the solar bismuth abundance, resulting in an \nr-process residual of 81\u00b13%. The present (n, \u03b3 ) cross-section measurement is also of relevance for the design \nof accelerator driven systems based on a liquid metal Pb\/Bi spallation target.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":38302189,"openaccessinfo":{"externalids":{"MAG":"2069920111","ACL":null,"DOI":"10.1103\/PhysRevC.74.025807","PubMedCentral":null,"ArXiv":"nucl-ex\/0610040"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gravel size sediment beds are tested under the combined influence of simulated wave action and co-linear currents in a laboratory flume. Critical current speed, at threshold, increases with increasing size. Superimposed wave energy causes a small reduction in the unidirectional current energy. For low values of wave-induced near bed current velocities, the resistance to erosion increases when the wave period decreases from 10 to 6 s. Finally, combined critical shear stresses are found to be lower than those predicted using the Shields curve, as modified for oscillatory flow. Grain protrusion is suggested as a mechanism to explain this divergence.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140583968,"openaccessinfo":{"externalids":{"MAG":"2033149032","ACL":null,"DOI":"10.1111\/J.1365-3091.1994.TB01434.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Around 2-10% of women have premenstrual symptoms that severely disrupt daily living.1\u20133 When such symptoms are dominated by severe disturbances of mood and behaviour, the condition has been named premenstrual dysphoric disorder (PMDD).4 Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), is licensed in the UK for the treatment of PMDD. Here, we discuss the diagnosis of PMDD and the evidence for the efficacy of fluoxetine and other SSRIs in its treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8657587,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/dtb.2002.40970","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Several capacitors may be connected together in a variety of applications. Multiple connections of capacitors act like a single equivalent capacitor. The total capacitance of this equivalent single capacitor depends both on the individual capacitors and how they are connected. There are two simple and common types of connections, called series and parallel, for which we can easily calculate the total capacitance. Certain more complicated connections can also be related to combinations of series and parallel.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":146550359,"openaccessinfo":{"externalids":{"MAG":"3010801912","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report on the results of the low-frequency (1\/f, where f is frequency) noise measurements in MoS2 field-effect transistors revealing the relative contributions of the MoS2 channel and Ti\/Au contacts to the overall noise level. The investigation of the 1\/f noise was performed for both as fabricated and aged transistors. It was established that the McWhorter model of the carrier number fluctuations describes well the 1\/f noise in MoS2 transistors, in contrast to what is observed in graphene devices. The trap densities extracted from the 1\/f noise data for MoS2 transistors, are 2\u2009\u00d7\u20091019\u2009eV\u22121cm\u22123 and 2.5\u2009\u00d7\u20091020\u2009eV\u22121cm\u22123 for the as fabricated and aged devices, respectively. It was found that the increase in the noise level of the aged MoS2 transistors is due to the channel rather than the contact degradation. The obtained results are important for the proposed electronic applications of MoS2 and other van der Waals materials.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":5293494,"openaccessinfo":{"externalids":{"MAG":"1603442421","ACL":null,"DOI":"10.1063\/1.4871374","PubMedCentral":null,"ArXiv":"1312.6868"},"license":null,"url":"https:\/\/pubs.aip.org\/aip\/apl\/article-pdf\/doi\/10.1063\/1.4871374\/13907682\/153104_1_online.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"AIMS\nHypoxia, ischaemia, and exogenous chemicals can induce extracellular and intracellular acidosis, but it is not clear which of these types of acidosis affects endothelial cell function. The synthesis and release of endothelium-derived relaxing factors (EDRFs) are linked to an increase in cytosolic Ca(2+) concentration, and we therefore examined the effects of extracellular and intracellular acidosis on Ca(2+) responses and EDRF production in cultured porcine aortic endothelial cells.\n\n\nMETHODS AND RESULTS\nCytosolic pH (pH(i)) and Ca(2+) were measured using fluorescent dyes, BCECM\/AM (pH-indicator) and fura-2\/AM (Ca(2+)-indicator), respectively. EDRFs, nitric oxide (NO) and prostaglandin I(2) (PGI(2)) were assessed using DAF-FM\/DA (NO-indicator dye) fluorometry and 6-keto PGF(1alpha) enzyme immunoassay, respectively. HEPES buffers titrated to pH 6.4, 6.9, and 7.4 were used to alter extracellular pH (pH(o)), and propionate (20 mmol\/L) was applied to cause intracellular acidosis. Extracellular acidosis strongly suppressed bradykinin (BK, 10 nmol\/L)- and thapsigargin (TG, 1 micromol\/L)-induced Ca(2+) responses by 30 and 23% at pH(o) 6.9, and by 80 and 97% at pH(o) 6.4, respectively. During the examinations, there were no significant differences in pH(i) among the three groups at pH(o) 7.4, 6.9, and 6.4. Extracellular acidosis also inhibited BK-stimulated PGI(2) production by 55% at pH(o) 6.9 and by 77% at pH(o) 6.4, and NO production by 38% at pH(o) 6.9 and by 91% at pH(o) 6.4. The suppressive effects of extracellular acidosis on Ca(2+) responses and NO production were reversible. Propionate changed pH(i) from 7.3 to 6.9, without altering pH(o) (7.4). Intracellular acidosis had no effect on BK- and TG-induced Ca(2+) responses or NO production.\n\n\nCONCLUSION\nThese results indicate that extracellular, but not intracellular, acidosis causes endothelial dysfunction by inhibiting store-operated Ca(2+) entry, so helping to clarify the vascular pathophysiology of conditions such as ischaemia, hypoxia, acidosis, and ischaemia-reperfusion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204986998,"openaccessinfo":{"externalids":{"MAG":"2161168967","ACL":null,"DOI":"10.1093\/cvr\/cvp105","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/83\/1\/97\/17392150\/cvp105.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The probability is discussed of a close interrelationship between i) concentrations of lattice defects and associated free energy in minerals; and ii) solid state and chemical reactivity processes, in the formation of some ore deposits. The distributions of lattice defects and\/or free energy near four base metal sulfide ore deposits, as indicated by thermoluminescence, are analyzed and the conclusion reached that lattice defects due to strain may have played a very significant part in pre-ore ground preparation and the localization of the ore zones. Defects caused by low-level radioactivity and some trace elements should have similar effects, but in one, if not all, of the cases examined they appear to have been of negligible importance. It is suggested that in cases where obvious structural or petrologic controls for the emplacement of ore deposits appear to be lacking, the controls may have been inconspicuous concentrations of either lattice defects or above normal free energy.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":98595468,"openaccessinfo":{"externalids":{"MAG":"2134280809","ACL":null,"DOI":"10.2113\/GSECONGEO.63.6.671","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The process of moving the National Capital in Panajam has had an impact on the original ethnicity that inhabits the location, in this case, the Paser ethnicity. These ethnic communities experience patterns of subalternity relations such as their settlement land and livelihood land are suddenly determined without their knowledge, are not involved in decision-making processes, they are prohibited from accessing the zero point and the Central Government Core Area, and are not given space to become local workers in the work of the State Capital projects. This pattern of subalternity relations then developed into a communal identity which became the basis for the spirit of this community to carry out struggles for emancipation. How this community defines itself as a subaltern is the formulation of the problem that will be answered by this research as well as a research objective. This research approach is based on a critical paradigm because the Paser ethnic community which is used as a research subject is in a cyborg position which requires the role of researchers as transformative intellectuals in helping them to get out of their problems. The research method used is a qualitative method with data collection in the form of interviews, FGDs, and observations, all of which are carried out in a participatory manner. The data were analyzed by finding patterns\/themes of meaning and presented narratively. The results of the study found that the pattern of unequal relationships gave rise to collective anxiety and collective perceptions as a subordinated group. The conclusion of this study is the pattern of subaltern relations of the 4 dominant forces, namely the state, companies, dominant culture, and transmigrants, which makes them perceive their group as subordinate. The expected suggestion is that this community needs to continue to build awareness together to continue the struggle for the existence of culture and life while continuing to strive for community empowerment in the form of capacity building.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":1,"2024-26":1}},"corpusid":258285787,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.11114\/smc.v11i4.6017","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/redfame.com\/journal\/index.php\/smc\/article\/download\/6017\/6147","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Delirium is an acute neuropsychiatric syndrome and one of the most common presenting symptoms of acute medical illnesses in older people. Delirium can be triggered by a single cause, but in most cases, it is multifactorial as it depends on the interaction between predisposing and precipitating factors. Delirium is highly prevalent in older patients across various settings of care and correlates with an increased risk of adverse clinical outcomes. Several pathophysiological mechanisms may contribute to its onset, including neurotransmitter imbalance, neuroinflammation, altered brain metabolism, and impaired neuronal network connectivity. Several screening and diagnostic tools for delirium exist, but they are unfortunately underutilized. Additionally, the diagnosis of delirium superimposed on dementia poses a formidable challenge \u2013 especially if dementia is severe. Non-pharmacological approaches for the prevention and multidomain interventions for the treatment of delirium are recommended, given that there is currently no robust evidence of drugs that can prevent or resolve delirium. This article aims to review the current understanding about delirium in older people. To achieve this goal, we will describe the epidemiology and outcomes of the syndrome, the pathophysiological mechanisms that are supposed to be involved, the most commonly used tools for screening and diagnosis, and prevention strategies and treatments recommended. This review is intended as a brief guide for clinicians in hospital wards to improve their knowledge and practice. At the end of the article, we propose an approach to improve the quality of care provided to older patients throughout a systematic detection of delirium.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":233450322,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fnagi.2021.626127","PubMedCentral":"8119654","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2021.626127\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Locomotor activity in the elevated plus-maze was studied in female white rats following chronic stress induction (measuring pain threshold in the course of 15-20 days). Anxiety and plasma corticosterone levels were determined. In control experiments in intact rats anxiety was lower and locomotor activity was higher in proestrus than in diestrus. There were no differences in anxiety and locomotor activity between diestrus and proestrus in rats exposed to chronic stress. In intact rats plasma corticosterone levels were the same in proestrus and diestrus. Following chronic stress plasma corticosterone level was significantly higher in proestrus than in diestrus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35164965,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The northwest-southeast-trending Atera fault, which is expressed geomorphologically and geologically, cuts many terraces of the Kiso River in central Japan. The authors measured the vertical and horizontal displacement of the fault from the offset of the terrace surfaces and faces (scarps). Seven displacement vectors were calculated in the fault plane. They show that (1) the horizontal displacement is about five times larger than the vertical; (2) the faulting, to date, has been consistently left lateral; (3) the rate of faulting seems to have been almost consistent (about 2\u20134 m\/1000 yrs.). It is noted that the Neo Valley fault is subparallel to the Atera fault, and that its displacement is also left lateral. Data on recent strike-slip fault displacements in central Japan, in part from this specific study, show a regular pattern of geographic distribution of strains.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128569512,"openaccessinfo":{"externalids":{"MAG":"2088568769","ACL":null,"DOI":"10.1130\/0016-7606(1965)76[509:AFAIDV]2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A flip-chip packaged two-dimensional (2-D) thermal flow sensor fabricated in CMOS technology is presented. The sensor consists of polysilicon resistor heaters, Al\/polysilicon thermopiles, and a substrate bipolar transistor located in the center of the sensor chip. The thermopiles and the transistor were used to measure the change of the flow-induced temperature distribution on the flow-sensing surface. The sensor chip was flip-chip packaged on a thin ceramic substrate using a copper pillar bump technology. The polysilicon resistor provides the necessary overheat of the chips, and thermal interactions with the flow are achieved via the pillar bump and the thin ceramic substrate. The operating principle for the packaged sensor remains the same as before packaging. The backside of the ceramic substrate provides a smooth surface for the sensor to be exposed to the flow. Meanwhile, the ceramic substrate holds the sensor chip and protects it from being contaminated or even destroyed by the corrosive environment. The packaged flow sensor shows the good performances compared with the unpackaged sensors. It can detect airflow speed up to 30 m\/s with accuracy of 0.5 m\/s and airflow direction in a full range of 360 with an accuracy of 6 at room temperature.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":37184672,"openaccessinfo":{"externalids":{"MAG":"2133657813","ACL":null,"DOI":"10.1109\/JSEN.2006.888599","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The construction and characteristics of film badges used at NRTS are described. Five types of film for use in the badges were investigated using radium 's and uranium helial phagocyt 's. Calibration curves are given. Methods for correcting the nonlinear response characteristics of film detectors are discussed. Procedures are described for automatically reading the film and recording the results on punched cards. The data recording techniques also provide for monthly and annual exposure experience reports. (D.E.B.)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209659858,"openaccessinfo":{"externalids":{"MAG":"2265893946","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Oxidation of stannous chloride by Thiobacillus ferrooxidans was studied manometrically. At low stannous ion concentrations, initial oxidation rate was proportional to concentration. Optimum pH for oxidation was 2.3 optimum temperature was 37-40 degrees C. Spectrophotometry showed reduction of cytochromes in suspensions of whole cells on addition of ferrous, stannous, or cuprous salts. Cytochrome c reductase activity in cell-free extracts was assayed with ferrous, stannous, or cuprous ions as electron donors. It appears unlikely that an essential non-biological reaction, the reduction of ferric ions by stannous or cuprous ions, is involved. Growth of T. ferrooxidans was not obtained with either stannous chloride or stannous sulphate as sole energy source.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39793327,"openaccessinfo":{"externalids":{"MAG":"2076265453","ACL":null,"DOI":"10.1139\/M77-047","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Six years after surgery and radioiodine treatment of a medullary thyroid carcinoma a woman patient developed pulmonary metastases with radioiodine uptake. These were treated with 11.7 GBq (twice 150 mCi) 131I. Retrospective immunohistochemistry of the primary tumour revealed a mixed medullary and follicular pattern. Since it is likely that in patients having such follicular variants of medullary thyroid carcinoma the metastases are of a similar pattern, immunohistochemistry should aim at identifying follicular structure, followed by initiation of whole body scintigraphy and radioiodine treatment if appropriate.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38151870,"openaccessinfo":{"externalids":{"MAG":"1984357000","ACL":null,"DOI":"10.1055\/S-2008-1068215","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thirty blood samples were collected from people infected with HCV and collected 30 blood samples from healthy individuals as a control group. The samples were collected from the virus department at Diwaniyah Teaching Hospital, Women's Hospital and Educational Children and the Blood Bank in Diwaniyah Governorate, during the period from July 2018 until February 2019. Antibodies (Anti-HCV ) to HCV were detected in the infected serum using ELISA technique, and the diagnosis was confirmed Using the polymerase chain reaction test. Select gene polymorphism of interleukin -6 at site 174, which represents 3 genotypes GG, GC, CC in patients with HCV and control group. GG was significantly increased in patients with hepatitis C virus (63.3%) compared to the control group (30 %). The genotypes GC, CC were significantly decreased in patients with hepatitis C virus (16.7% and 20%) compared with the control group (43.3% and 26.7%), respectively. It also identified gene polymorphism of interleukin -10 at site 592, which represented 3 genotypes AA, AC, CC in patients with hepatitis C virus and control group. Genotype AC was significantly increased in patients with hepatitis C virus (53%) compared with the control group (30%). The genotypes CC, AA were significantly decreased in patients with hepatitis C virus (26.7% and 20%) compared with the control group (26.7% and 43.3%) respectively. Conclude from our current study that genotypes or alleles of IL-6 and IL-10 may play an essential role in increasing the risk of HCV in humans or play a vital role for prevention against.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":201204873,"openaccessinfo":{"externalids":{"MAG":"2966134575","ACL":null,"DOI":"10.26452\/IJRPS.V10I3.1418","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Surveys that utilize multiple geophysical methods offer greater insights about the subsurface because each one generally yields different information. Common approaches to integrating or 'fusing' multidimensional geophysical data are investigated utilizing computer graphics, geographical information system (GIS), mathematical and statistical solutions. These approaches are synthesized into graphical, discrete and continuous domains. It is shown that graphical approaches allow complex visualizations of the subsurface, but only images are generated and their dimensionality tends to be low. Discrete methods incorporate any number of geophysical dimensions, allow application of powerful Boolean operations, and produce unambiguous maps of anomaly presence or absence, but many of these methods rely on arbitrary thresholds that define only robust anomalies. Continuous data integrations offer capabilities beyond other methods because robust and subtle anomalies are simultaneously expressed, new quantitative information is generated, and interpretive data are derived in the form of regression weights, factor loadings, and the like, that reveal interrelationships and underlying dimensionality. All approaches are applied to a common data set obtained at Army City, Kansas, a World War I era commercial complex that serviced troops in nearby Camp Funston (now Fort Riley). Utilizing data from six geophysical surveys (magnetic gradiometry, electrical resistivity, ground\u2010penetrating radar, magnetic susceptibility, soil conductivity, aerial thermography), various data integrations reveal the structure of this nearly forgotten town. Copyright \u00a9 2005 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":140568646,"openaccessinfo":{"externalids":{"MAG":"1971492509","ACL":null,"DOI":"10.1002\/arp.268","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The essay clarifies the nature and surveys the main activities of the so called \u00abmixed\u00bb banks which operated in Italy from the end of XIXth century to the early 1930's, when the Italian financial system was radically reformed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":192580974,"openaccessinfo":{"externalids":{"MAG":"2276639954","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pseudo MV-algebras (see e.g., [4, 6, 8]) are non-commutative extension of MV-algebras. We show that every pseudo MV-algebra is isomorphic to the algebra of action functions where the binary operation is function composition, zero is x\u2227y and unit is x. Then we define the so-called difference functions in pseudo MV-algebras and show how a pseudo MV-algebra can be reconstructed by them.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":124600382,"openaccessinfo":{"externalids":{"MAG":"2330701498","ACL":null,"DOI":"10.7151\/DMGAA.1148","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A survey is given of the actual causes of occupational dermatoses and the variation in their incidence in a series of 4,529 patients seen at the out-patient clinic for skin diseases in the Institute of Occupational Health, Helsinki, and its precursor, during the 27-year period from 1946 to 1972. The overall incidence was highest for alkalis and detergents, cement, oil of turpentine and other solvents. Due to the increased use of synthetic resins in recent years a rise was seen in the frequency of eczema caused by these substances. Nevertheless, eczema due to rubber chemicals has also increased. The decreased incidence of turpentine eczema reflects its reduced use. In 45% of the cases the diagnosis was verified by positive epicutaneous tests. Of the 8,057 patients admitted because of a suspected occupational skin disorder, a non-occupational skin disease was diagnosed or the occupational origin remained unproved in 3,528 cases. The most important differential diagnoses and the differences in the location of the skin changes in the non-occupational as compared with the occupational group are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30728512,"openaccessinfo":{"externalids":{"MAG":"2416780078","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the current paper, we propose to fuse together stored data (tables) and their functional dependencies (FDs) inside a DBMS. We aim to make FDs first-class citizens: objects which can be queried and used to query data. Our idea is to allow analysts to explore both data and functional dependencies using the database interface. For example, an analyst may be interested in such tasks as: \"find all rows which prevent a given functional dependency from holding\", \"for a given table, find all functional dependencies that involve a given attribute\", \"project all attributes that functionally determine a specified attribute\". \nFor this purpose, we propose: (1) an SQL-based query language for querying a collection of functional dependencies (2) an extension of the SQL SELECT clause for supporting FD-based predicates, including approximate ones (3) a special data structure intended for containing mined FDs and acting as a mediator between user queries and underlying data. We describe the proposed extensions, demonstrate their use-cases, and finally, discuss implementation details and their impact on query processing.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":218674630,"openaccessinfo":{"externalids":{"MAG":"3024808852","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2005.07992"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thujone is thought to be the main constituent of medicinal herbs that have antidiabetic properties. Therefore, we examined whether thujone ameliorated palmitate-induced insulin resistance in skeletal muscle. Soleus muscles were incubated for < or =12 h without or with palmitate (2 mM). Thujone (0.01 mg\/ml), in the presence of palmitate, was provided in the last 6 h of incubation. Palmitate oxidation, AMPK\/acetyl-CoA carboxylase (ACC) phosphorylation and insulin-stimulated glucose transport, plasmalemmal GLUT4, and AS160 phosphorylation were examined at 0, 6, and 12 h. Palmitate treatment for 12 h reduced fatty acid oxidation (-47%), and insulin-stimulated glucose transport (-71%), GLUT4 translocation (-40%), and AS160 phosphorylation (-26%), but it increased AMPK (+51%) and ACC phosphorylations (+44%). Thujone (6-12 h) fully rescued palmitate oxidation and insulin-stimulated glucose transport, but only partially restored GLUT4 translocation and AS160 phosphorylation, raising the possibility that an increased GLUT4 intrinsic activity may also have contributed to the restoration of glucose transport. Thujone also further increased AMPK phosphorylation but had no further effect on ACC phosphorylation. Inhibition of AMPK phosphorylation with adenine 9-beta-d-arabinofuranoside (Ara) (2.5 mM) or compound C (50 muM) inhibited the thujone-induced improvement in insulin-stimulated glucose transport, GLUT4 translocation, and AS160 phosphorylation. In contrast, the thujone-induced improvement in palmitate oxidation was only slightly inhibited (< or =20%) by Ara or compound C. Thus, while thujone, a medicinal herb component, rescues palmitate-induced insulin resistance in muscle, the improvement in fatty acid oxidation cannot account for this thujone-mediated effect. Instead, the rescue of palmitate-induced insulin resistance appears to occur via an AMPK-dependent mechanism involving partial restoration of insulin-stimulated GLUT4 translocation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9306363,"openaccessinfo":{"externalids":{"MAG":"2103649615","ACL":null,"DOI":"10.1152\/ajpregu.00216.2010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective To establish the model of rabbit with hypercholesterolaemia-atherosclerosis and observe the changes of blood lipid density, and the positive expression of platelet\/endothelial cell adhesion molecule-1 (PECAM-1) and P-selectin (P-selectin, CD62P) in the rabbit aorta tissues. Then we investigated the influence of atorvastain to them. Methods Thirty healthy male white New-Zealand rabbits, were randomly divided into three groups: normal control group (group A), high-cholesterol diet group (group B) and high-cholesterol diet plus atorvastatin treatment group (group C). Density of the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) were evaluated. All segments of ascending aorta tissues were to determine the expression of PECAM-1 and P-selectin by RT-PCR, and the results were to do semi-quantitative analysis by UVP gel imaging system package Vision Works LS software. Results To the end of the trial, two rabbits died in Group A, four rabbits died in Group B, three rabbits died in Group C, And atherosclerosis model successfully established. The levels of TC, LDL-C were greater (p<0.05) in Group B than those in Group A and Group C, and the levels of TC, LDL-C were also greater (p<0.05) in Group C than those in Group A. The positive expression of PECAM-1 and P-selectin were significantly higher in Group B than in Group A, the expression of them was lower in Group C than in Group B, but still higher than in Group A. Conclusions Atorvastatin can effectively regulate lipid metabolism. PECAM-1 and P-selectin might be the two important atherogenic adhesion molecules. The adhesion molecules could promote the migration of inflammatory cells, further exacerbated the inflammatory response and participated the pathogenesis of atherosclerosis. Atorvastatin can reduce the expression of this two adhesion molecules, PECAM-1 and P-selectin.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":56677102,"openaccessinfo":{"externalids":{"MAG":"2313607315","ACL":null,"DOI":"10.1136\/HEARTJNL-2011-300867.79","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Metal-organic frameworks (MOFs) have emerged as promising light-harvesting platforms for energy-transfer materials. However, the targeted construction of MOFs with desirable photophysical properties and pore structures is still a challenge. Herein, 1,1,2,2-tetrakis(4-(pyridin-4-yl)phenyl)ethene (tppe) is selected as the ligand for the construction of light-harvesting MOFs due to its highly emissive and rigid backbone, which could benefit the light-harvesting performance of the MOFs. Three MOFs (MOFs 1-3) were obtained on the basis of different metal centers (Zn2+ and Cd2+) and carboxylate building blocks. The complete structure characterization of the MOFs helps the illustration of the principles for structure tuning of this system. All three MOFs exhibit strong tppe-originated photoluminescence emission, with quantum yields as high as 47.6%. The fluorescence quantum yield and time-resolved fluorescence studies reveal that a remarkable energy-transfer efficiency (up to 96%) was achieved in this system. These results clearly indicate tppe-MOFs could be promising light-harvesting materials.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206478090,"openaccessinfo":{"externalids":{"MAG":"2786267792","ACL":null,"DOI":"10.1021\/acsami.7b17755","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract This research compared early nineteenth-century species lists from the Elgin Botanic Garden, New York; Cambridge Botanic Garden, Massachusetts; Botanick Garden of South-Carolina; Botanical Garden of Transylvania University, Kentucky; and Bartram's Botanic Garden, Pennsylvania (two lists). Diversity was shown by more species being unique in each botanical garden than species common to the five botanical gardens. Global representation was demonstrated with species from all of the continents (excluding Antarctica) and the Cape of Good Hope region in the botanical gardens except the Botanick Garden of South-Carolina, which did not have Australian species. Only Bartram's Botanic Garden US market list did not have twice as many species reported to be hardy in the New York City climate than species requiring a greenhouse. There were more herbaceous than woody plants in five of the six lists with the exception again being the Bartram's Botanic Garden US market list. Among the uses agriculture, arts, diet, and medicine, only medicine comprised more than 25% of the species in the five botanical gardens except the Botanical Garden of Transylvania University. For all six lists, the historical information on hardiness and duration matched modern information for more than 75% of the species; however, native region matches were less than 75% for African species.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":251671895,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/14601176.2022.2097429","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The optical properties of a transparent optical resin (HMA\/ST) containing ternary rare earth complex are reported. Based on Judd-Ofelt (J-O) theory, the J-O parameters were calculated to be omega2 = 10.139 4 x 10(-20) cm2, omega4 = 3.810 9 x 10(-20) cm2, omega6 = 9.050 7 x 10(-20) cm2 by using the emission spectrum of optical resin containing Eu (TTA)3 phen-0.31 wt%. The J-O parameters were used to calculate the total radiative transition rate (456.6 s(-1)) and radiative lifetime (2 190.1 micros) of the excited state 5D0. The stimulated emission cross-sections a and the fluorescence branch ratio beta parameters for the transitions of 5D0 --> 7F(J), (where J' = 1, 2, 4 and 6) were also evaluated. By analyzing the calculated J-O parameters, it is concluded that the excited state of Eu3+ in optical resin has a long radiative lifetime and large emission cross-section, which shows that the optical resin containing rare earth complex can be used for stimulated emission amplification or as a laser material.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33799088,"openaccessinfo":{"externalids":{"MAG":"2379744543","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Over the past 25 years, CORONA satellite imagery has become an integral part of archaeological research, especially for arid, sparsely vegetated regions such as the Middle East. Since 2020, a new archive of satellite imagery gathered by the US spy satellite programme that succeeded CORONA\u2014HEXAGON\u2014has become widely available for download via the United States Geological Survey. This photographic archive has enormous potential for archaeological research. Here, the authors seek to lower the barriers to accessing and using this imagery by detailing the background, technical specifications and history of the HEXAGON archive. Four case studies illustrate the benefits and limitations of HEXAGON imagery for archaeological and historical research in the Middle East and beyond.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":247459559,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.15184\/aqy.2022.22","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ligand exchange reaction between monodisperse Au25(2-PET)18 (2-PET: 2-phenylethylthiolate) clusters and 1,1'-binaphthyl-2,2'-dithiol (BINAS) was long thought to induce decomposition of the cluster (Si et al., J. Phys. Chem. C, 2009). We repeated the experiment and analyzed the reaction products using MALDI-TOF mass spectrometry. The spectra clearly indicate successful ligand exchange, bidentate binding of the BINAS ligand and intact Au25 clusters. The reaction products are identified as Au25(2-PET)18-2x(BINAS)x (x = 1-4) for a 24 h reaction with a 50-fold molar excess of BINAS. Two likely binding motifs are discussed. Analysis of atomic distances in both the cluster and the free ligand indicates interstaple binding connecting the central sulfur atom of the protecting (SRAu)2SR with the outer sulfur atom of a second unit. The results presented have implications on the binding position of BINAS in Au38(SR)24-2x(BINAS)x clusters.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13031387,"openaccessinfo":{"externalids":{"MAG":"2100626693","ACL":null,"DOI":"10.1039\/c3cp52634h","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/archive-ouverte.unige.ch\/unige:29643\/ATTACHMENT01","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Microcephaly (small head) is clinically important only if there is concomitant micrencephaly (small brain). Extensive studies on patients in mental institutions have shown that there is close correlation among microcephaly, micrencephaly, and mental retardation when the head is more than three standard deviations below the norm. If the small head is less than two standard deviations below the norm, no strong correlation exists with either small brain or mental retardation. High\u2010resolution ultrasound permits imaging of the fetal head in utero, allowing accurate evaluation of head size and detection of intracranial anomalies. The microcephalics detected in utero over a 2\u2010year period form the basis of this series, showing close correlation with the known clinical data on children with microcephaly. An approach to ultrasound detection and evaluation of fetal microcephaly is proposed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33394654,"openaccessinfo":{"externalids":{"MAG":"2110960625","ACL":null,"DOI":"10.1002\/jcu.1870080104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An alternative scheme is proposed for teleportation of an unknown atomic-entangled state. The scheme is based on the resonant interaction of a two-mode cavity field with a \u039b-type three-level atom. In contrast with the previously proposed scheme of [Commun. Theor. Phys. 47 (2007) 253], the present scheme is ascendant, since the fidelity is 1.0 in principle similarly without the Bell-state measurement. The scheme may be generalized to not only the teleportation of the cavity-mode-entangled-state but also the teleportation of the multi-atomic entangled states included in generalized GHZ states. And the scheme is experimentally feasible based on the current cavity QED technique.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250907395,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0253-6102\/49\/3\/20","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objectives: Patients with cystic fibrosis (CF) who have exocrine pancreatic insufficiency (EPI) require treatment with pancreatic enzyme replacement therapy (PERT) to maintain adequate nutrition and age-appropriate growth and weight gain. Liprotamase, a nonporcine, highly purified biotechnology-derived PERT, has demonstrated significant efficacy in fat and protein malabsorption in patients with EPI compared to placebo. This study of liprotamase is the first ever long-term trial of a PERT to evaluate safety and nutritional parameters. Methods: This phase III 12-month open-label trial assessed the safety, tolerability, and long-term nutritional effects of liprotamase treatment in patients with CF and EPI 7 years and older. All of the patients were required to discontinue their long-term use of porcine PERTs at the time of enrollment. Dosing started at 1 capsule of liprotamase (32,500 US Pharmacopoeia (USP) units crystallized cross-linked lipase, 25,000 USP units crystallized protease, and 3,750 USP units amorphous amylase) per meal or snack; dose could be increased based on protocol-defined parameters. Results: A total of 215 subjects were enrolled and 214 received at least 1 dose of liprotamase (mean 5.5 capsules per day). During the study period, height, weight, and body mass index z scores and lung function as measured by forced expiratory volume in 1 second were stable. There were no clinically meaningful changes in laboratory tests, including levels of fat-soluble vitamins. Liprotamase was well tolerated without any significant safety concerns. Adverse events, primarily gastrointestinal, led to treatment discontinuation for 36 subjects (16.8%), most within the first 3 months. Conclusions: Treatment with a mean of 5.5 capsules of liprotamase per day, during meals and snacks, for up to 12 months was safe, well tolerated, and associated with age-appropriate growth and weight gain or weight maintenance in subjects with CF-related EPI.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12498594,"openaccessinfo":{"externalids":{"MAG":"2330281064","ACL":null,"DOI":"10.1097\/MPG.0b013e31823315d1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OpenCourseWare platforms for educational resources have the potential to open new horizons for knowledge sharing and e-learning by reaching learners beyond the constraints of traditional learning systems. SlideWiki is a crowd-sourcing platform that aims to rethink the creation and sharing of knowledge by providing an environment where authors can collaborate, reuse, adapt and share slide contents for educational purposes. As an OpenCourseWare platform, SlideWiki intends to make Open Educational Resources more accessible for all users, including those with disabilities, within formal and informal learning settings. Moreover, the platform offers collaborative tools that enable authors and contributors to translate the slide content. To address the implementation, scalability, usability, and adoption of the platform, it has been designed and deployed in many different learning settings with large-scale trials across Europe. At the time of writing, 56 trials have taken place in different geographical and cultural regions, organizational units, and institutions, covering various teaching and learning scenarios. The experiences and feedback from the trials have influenced the redesign of SlideWiki in terms of accessibility and openness. This paper discusses the findings of the large-scale trials and how they influenced the technical redesign of the platform. It also shows how incorporating user feedback into the technical development process can improve accessibility and collaboration.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":53039006,"openaccessinfo":{"externalids":{"MAG":"2896936389","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to validate an employee satisfaction model and to determine the relationships between the different dimensions of the concept, using the structural equation modelling approach (SEM). A cross-sectional quantitative survey design was used to collect data from a random sample of (n=759) permanent employees of a parastatal organisation. Data was collected using the Employee Satisfaction Survey (ESS) to measure employee satisfaction dimensions. Following the steps of SEM analysis, the three domains and latent variables of employee satisfaction were specified as organisational strategy, policies and procedures, and outcomes. Confirmatory factor analysis of the latent variables was conducted, and the path coefficients of the latent variables of the employee satisfaction model indicated a satisfactory fit for all these variables. The goodness-of-fit measure of the model indicated both absolute and incremental goodness-of-fit; confirming the relationships between the latent and manifest variables. It also indicated that the latent variables, organisational strategy, policies and procedures, and outcomes, are the main indicators of employee satisfaction. This study adds to the knowledge base on employee satisfaction and makes recommendations for future research.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55717195,"openaccessinfo":{"externalids":{"MAG":"2558222798","ACL":null,"DOI":"10.22495\/JGR_V4_I4_P8","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We provide a real-life application of a large scale affirmative action policy in school choice in the context of engineering school admissions in India where students not only care about what program they are matched to but also what type of seat category they are admitted under. We explain the market and the mechanism currently in use. Two significant shortcomings of the current mechanism are explained. The affirmative action policy in use leaves many seats vacant even though there are students who would take these seats. We provide the insight of a potential matching-theoretical solution to these problems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":157341049,"openaccessinfo":{"externalids":{"MAG":"2587347861","ACL":null,"DOI":"10.1257\/AER.P20171049","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \nThis study explored whether snow gums (Eucalyptus pauciflora) in a subalpine region use circadian rhythms for photosynthesis and whether age and exposure affect photosynthetic machinery. Fv\/Fm, SPAD and specific leaf area (SLA) were measured in individual leaves to assess variation in leaf traits. Fv\/Fm was not significantly different between exposed and sheltered trees, but old leaves had significantly higher Fv\/Fm values than young leaves. SPAD was higher in exposed trees and old leaves had significantly higher chlorophyll content. SLA was significantly lower in old leaves, and sheltered leaves had significantly higher SLA than exposed leaves. Increase in SLA with exposure was greater in young leaves. Branches from sheltered and exposed E.\u00a0pauciflora were harvested then placed in light and dark treatments. Stomatal conductance was tested at various times to determine if leaf stomata were opening without access to sunlight. At the time of this experiment, there had been no previous known studies on circadian rhythms in E. pauciflora. Conductance rates were higher in the light treatment, and across this treatment it was higher at 11\u00a0am than at night. There was no effect of exposure on conductance rates in the light treatment. In the dark treatment, exposed leaves had lower conductance rates than sheltered leaves. For sheltered and exposed leaves, conductance was greater at dawn than at 11\u00a0pm and greater again at 11\u00a0am than at dawn, suggesting E. pauciflora do use circadian rhythms for photosynthesis.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":89790039,"openaccessinfo":{"externalids":{"MAG":"2768283940","ACL":null,"DOI":"10.22459\/RFEKNP.11.2017.04","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract. Mineral dust plays a significant role in climate change\nand air quality, but large uncertainties remain in terms of dust emission\nprediction. In this study, we improved treatment of the dust emission\nprocess in a global 3-D chemical transport model (GEOS-Chem v12.6.0), by\nincorporating the geographical variation of aerodynamic roughness length\n(Z0), smooth roughness length (Z0s) and soil texture and by introducing the Owen effect and the formulation of the sandblasting efficiency\n\u03b1 by Lu and Shao\u00a0(1999). To investigate the impact of the modifications incorporated in\nthe model, several sensitivity simulations were performed for a severe dust\nstorm during 27\u00a0March to 2\u00a0April\u00a02015 over northern China. Results\nshow that simulated threshold friction velocity is very sensitive to the\nupdated Z0 and Z0s field, with the relative difference ranging\nfrom 10\u2009% to 60\u2009% compared to the original model with a uniform value. The\ninclusion of the Owen effect leads to an increase in surface friction velocity,\nwhich mainly occurs in the arid and semi-arid regions of northwest China.\nThe substitution of a fixed value of \u03b1 assumed in the original scheme with\none varying with friction velocity and soil texture based on observations\nreduces \u03b1 by 50\u2009% on average, especially over regions with sand\ntexture. Comparisons of sensitivity simulations and measurements show that\nthe revised scheme with the implementation of updates provides more realistic\nthreshold friction velocities and PM10 mass concentrations. The\nperformance of the improved model has been evaluated against surface\nPM10 observations as well as MODIS aerosol optical depth (AOD) values,\nshowing that the spatial and temporal variation of mineral dust are better\ncaptured by the revised scheme. Due to the inclusion of the improvement,\naverage PM10 concentrations at observational sites are more comparable\nto the observations, and the average mean bias (MB) and normalized mean bias\n(NMB) values are reduced from \u2212196.29\u2009\u00b5g\u2009m\u22123 and\n\u221252.79\u2009% to \u221247.72\u2009\u00b5g\u2009m\u22123 and \u221222.46\u2009% respectively.\nOur study suggests that the erodibility factor, sandblasting efficiency and\nsoil-related properties which are simply assumed in the empirical scheme may\nlack a physical mechanism and spatial\u2013temporal representativeness. Further study\nand measurements should be conducted to obtain a more realistic and detailed\nmap of these parameters in order to improve dust representation in the\nmodel.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":228939012,"openaccessinfo":{"externalids":{"MAG":"3094903328","ACL":null,"DOI":"10.5194\/acp-2020-984","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/acp.copernicus.org\/articles\/21\/4319\/2021\/acp-21-4319-2021.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"To evaluate the sensitivity of the positron emission tomography (PET) portion of fluorine-18 fluorodeoxyglucose- PET-computerized tomography ((18)F-FDG-PET\/CT) to detect solid malignant renal masses, and to assess for metabolic differences based on histopathological type. Nineteen subjects with 25 known solid malignant renal masses who underwent (18)F-FDG-PET\/CT were retrospectively evaluated. Qualitative analysis of the PET portion only of (18)F-FDG-PET\/CT examinations to assess visual detection of renal masses was initially performed in blinded fashion. Subsequently, measurements of standardized uptake value (SUV) and lesion-to-background ratios were performed for all masses and compared between histopathological types. Of 25 solid malignant renal masses, 18 were renal cell carcinoma (RCC), 3 were renal lymphoma, and 4 were metastases. Twenty-two of 25 were detectable, and all were correctly spatially localized. Fifteen of 22 detectable lesions were exophytic in configuration. The three non-detectable masses were non-exophytic RCC's with average diameter of 2.0cm. Fifteen of 18 of RCC were detectable, whereas all renal lymphomas and metastases were detectable. None of the metabolic parameters were statistically significant between RCC and renal lymphoma. However, all metabolic parameters were statistically significantly greater for renal metastases compared to RCC and renal lymphoma, and for clear cell RCC compared to papillary RCC. In conclusion, the PET portion of (18)F-FDG-PET\/CT had a sensitivity of 88% for detection of solid malignant renal lesions in patients with known renal malignancy, and reveals differences in metabolic activity based on histopathological type, which may be useful for purposes of individualized medicine. Further studies are required for more in depth assessment of these preliminary observations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25194392,"openaccessinfo":{"externalids":{"MAG":"129311452","ACL":null,"DOI":"10.1967\/s002449910067","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Despite this promising potential, it is important to remember that investing in Bitcoin also involves risk. The price of Bitcoin is very volatile, and its value can change dramatically in a short amount of time. In addition, regulations regarding cryptocurrencies are still unclear in many countries, and regulatory changes could affect the price and adoption of Bitcoin. Security is also an important factor, as Bitcoin can be vulnerable to cyberattacks and theft. This study aimed to conduct studies related to the potential of bitcoin cryptocurrency as an asset for future investment as well as the potential risks that exist in this asset. Literature search efforts are carried out by searching on search engines using certain keywords. Articles that match the inclusion criteria are reviewed in depth. Bitcoin's potential as a future investment alternative is highly dependent on factors such as value growth, institutional adoption, and developments in blockchain technology. Nonetheless, it is important to be aware of the risks associated with investing in cryptocurrencies and to carry out in-depth research and consulting before making any investment decisions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259819787,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.37275\/oaijss.v6i4.165","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/journalsocialsciences.com\/index.php\/oaijss\/article\/download\/165\/415","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objectives: This article outlines the development of the Calmer Life project, a partnership established between researchers and faith-based and social service organizations to examine the effectiveness of cognitive behavioral therapy (CBT) incorporating religious\/spiritual components for older African Americans in low-income communities. Method: The program was designed to bypass several barriers to delivery of CBT within the specified community; it allows multimodal delivery (in person or by telephone) that occurs outside traditional mental health settings through faith-based organizations and neighborhood community centers. It includes religion\/spirituality as an element, dependent upon the preference of the participant, and is modular, so that people can select the skills they wish to learn. Established relationships within the community were built upon, and initial meetings were held in community settings, allowing feedback from community organizations. Results: This ongoing program is functioning successfully and has strengthened relationships with community partners and facilitated increased availability of education and services in the community. The lessons learned in establishing these partnerships are outlined. Conclusions: The growth of effectiveness research for late-life anxiety treatments in underserved minority populations requires development of functional partnerships between academic institutions and community stakeholders, along with treatment modifications to effectively address barriers faced by these consumers. The Calmer Life project may serve as a model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12816311,"openaccessinfo":{"externalids":{"MAG":"1976381497","ACL":null,"DOI":"10.1080\/13607863.2012.660621","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The demarcation of borders is a process in which spatial orders and relations are configured. It is central to the understanding of the production of social relations and cultural meanings in border areas. This article uses a social constructionist view to capture the variegated meanings that border procures during social changes and social processes. In doing so, this paper understands border as inherently a social product. Its social significance and definition is not fixated a priori, but constituted and negotiated within networks of relations and events. In the meantime, recent advancement in human geography has made a powerful claim that space and spatial relations are important constitutive elements in all social and cultural processes. The border is certainly no exception. The transitional zone defined by geographical borders is not simply a container of social, economic and cultural processes. On the contrary, the production of space and spatial relations is a critical dimension in the constitution of society and culture. With these theoretical points of entry in mind, this paper suggests that border as a social construct can imply closure and simultaneously openness. Social groups in different positions interpret the meanings of borders in radically distinct ways. The power of borders in defining spatial and social orders lies in the production of sociocultural differences and hence the division between \"us\" and \"others\". Borders not only delineate respective nation-states, but also create differentiated spaces of identity and belonging. Besides, borders situate different political and social entities in divided social, economic and political contexts, thus holding the potential to create gradients of regional development. In this sense, borders imcubate possibilities of exchange and cooperation in order to reconfigure established orders and relations. Following this view, this article develops a re-conceptualization and re-interpretation of the border. It reviews the current literature of border studies in human geography by engaging with a number of parallel topics. The main body of the article starts by briefly reviewing some conceptual explanations of borders and border areas. It then moves to elaborate on the sociocultural significances of borders, with specific focuses on implications of closure and openness. The following section turns its attention to the issue of openness in particular, and review extant studies of cross-border spatial practices. Three viewpoints can be concluded from discussions in this article. First, the border is an important symbolic marker. It defines the social and cultural differences between \"us\" and \"others\". It also allocates social members to different social and political entities, thus creating differentiated spaces of belonging. Second,because of the existence of borders, regions at the two sides of the borders are thus embedded in radically distinct social, economic and political contexts. This results in cross-border regional disparity, which in turn creates opportunities for cross-border exchange and cooperation. Finally, for a significant number of social members,the border is constitutive of their everyday social life. It is a socio-spatial order that they need to constantly negotiate and respond to. Often, they are set to challenge established spatial orders, but in the meantime they are able to take advantage of the spatial relations defined by borders to create new possibilities of life.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":147949586,"openaccessinfo":{"externalids":{"MAG":"2366738126","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The San Luis Valley Health and Aging Study is a population-based epidemiologic study of chronic illness and disability among Hispanic and non-Hispanic white persons over the age of 60 in two counties in rural southern Colorado, USA. Between 1993 and 1995, we examined the prevalence of impaired executive cognitive functioning in a sample of 1,313 individuals living both in the community and in nursing homes. Overall, 1 person in 3 was found to have at least mild impairment, while 1 in 6 had moderate to severe deficits. Increasing levels of executive functioning impairment were associated with lower education, advancing age, and Hispanic ethnicity. After controlling for education and acculturation, the differences by ethnic group were no longer significant.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43655786,"openaccessinfo":{"externalids":{"MAG":"2045049826","ACL":null,"DOI":"10.1159\/000065638","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ENH-1070, a 9-page fact sheet by Robert H. Stamps, Jeffrey G. Norcini, Timothy K. Broschat, and Charles W. Meister, lists herbicides for use in nurseries to reduce weed management costs in nurseries and maintenance costs in landscapes. Includes a table of tolerant palms and cycads for pre-emergent and post-emergent herbicides. Published by the UF Department of Environmental Horticulture, August 2007.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":228637845,"openaccessinfo":{"externalids":{"MAG":"3035016978","ACL":null,"DOI":"10.32473\/edis-ep335-2007","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32473\/edis-ep335-2007","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This article proposes to revisit the theory of satisfaction by integrating musical quality, functional and emotional value, as well as equity and consumer behavioral intention in the same model. The study was conducted in the context of a jazz festival with 140 individuals. Initially, the results indicate the influence of musical quality, fairness, emotional value and utility value on satisfaction. In a second step, musical quality and fairness influence emotional value and functional value. Finally, it turns out that emotional value, utility value, and satisfaction influence consumers' behavioral intentions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234468113,"openaccessinfo":{"externalids":{"MAG":"3113982339","ACL":null,"DOI":"10.36713\/epra5904","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.36713\/epra5904","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background\n\nThe year 2020 has been through the occurrence of a pandemic caused by a virus known as SARS-CoV-2. The uncontrolled worldwide spread of COVID-19 and the rapid transmission of this virus lead to more and more cases, which results in a massive data stream. Each day a new set of data points are being reported regarding the number of positive test results, patients hospitalized, deaths, ventilator shortages, etc. This paper reviews Blockchain technology principles that suit it for data sharing of the pandemic and highlights the potential applications and opportunities in allying this form of data deposition and sharing for combating the COVID-19 pandemic.\nResults\n\nBlockchain has potential application in rapid data sharing of COVID-19 associated data. Data sharing using Blockchain is among the most influencing and practical approaches that healthcare data management can utilize to be more efficacious. Despite Blockchain robustness, it still has limitations that need to be considered in this paper.\nConclusions\n\nThe key concept of Blockchain technology is decentralization, which provides high performance and security for records stored on the net. Moreover, Blockchain is accessible to every participating block in the network. As a result, Blockchain can play an important role in storing and sharing medical records by giving global secure access to trusted data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":237785745,"openaccessinfo":{"externalids":{"MAG":"3176815068","ACL":null,"DOI":"10.21203\/rs.3.rs-631306\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-631306\/latest.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background The beginning of metastasis poorly affects the prognosis of breastcancer patients. Lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. We have tried to find out if the routine Chest X Ray (CXR) could play a role for early detection of lung metastasis, during the prognosis of these patients. Methods The files of the breast cancer patients between 1996 to 2006 (1739 patients) have reviewed. Clinical characteristics of patients with pulmonary metastasis have recorded. Patients, who lacked imaging files or lacked an appropriate follow-up, have excluded. Data have analyzed by SPSS 11.5. The survival analyses have performed by using the Kaplan-Meier method. Results Fifty-six patients, median age 46, have entered into this retrospective study. Median tumor size was 4cm; median number of Lymphadenopathy (LAP) was 4. The intermediate grade has detected in 74% of patients. All patients have received adjuvant treatment. Median time from cancer diagnosis to pulmonary metastasis was 22 months. Pulmonary metastasis has detected by control CXR in77.4% and patients' symptoms in 22.6%. Forty eight patients have received chemotherapy in metastatic phase. In 28 patients (50%), other sites of metastasis (bone, liver, and brain) have discovered.The most frequent pattern of lung recurrence was pulmonary nodule (44.6%), followed by pleural effusion (28.6%). Median survival was 27.5; median survival from pulmonary metastasis was 8 m. Conclusion Early detection of pulmonary metastasis by CXR did not affect patients' endpoints. None of the probable prognostic factors have shown a significant effect on patients' outcome. Despite systemic treatment, survival after metastasis is low.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16064745,"openaccessinfo":{"externalids":{"MAG":"2144984981","ACL":null,"DOI":null,"PubMedCentral":"4142908","ArXiv":null},"license":"CCBYNC","url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study presents arguments for a constructivist perspective and qualitative methodologies for environmental education research. Its purpose was to explore student teachers' pre-instructional perspectives on the environment and environmental education, as well as on the relationship between humans and the natural world. Interviews were conducted with students in a South African teacher education program with mandatory environmental education sessions. Three data sets consisting of one-on-one interviews were collected. The first set comprised single interviews with ten students in 1992 and the second set involved multiple interviews with nine students and single interviews with three other students in 1993. The third data set comprised single interviews conducted by an independent researcher to eUcit students' experiences of the data collection process. Students' conceptualisations of the environment, including associated beliefs on environmental education, are described within five categories: social, political, biophysical, integrated systems, and part of one's self. Thirteen conceptualisations of human-nature relationships are described, beginning with one portraying the shared origin of humans and nature, then four portraying human-nature connections. The remaining eight are organised on the basis of value which students attributed to the natural world: four conceptualisations relating to intrinsic value, one to inherent value, and three to instrumental value. Students' experiences of the environmental education sessions are also described, drawing attention to themes. Two conclusions are drawn from the analyses. First, students' pre-instructional beliefs exhibit important elements of conceptions of environment and environmental issues described in the literature. Similarly, their conceptualisations of human-nature relationships traverse a range of eco-philosophical perspectives and include elements of most of the categories developed in this Uterature. These conclusions are used to argue for the place of eco-philosophical literature within environmental teacher education and for a pedagogical approach which encourages students to expUcate and critique their personal beliefs. Dr. David Bateson Research supervisor","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":155207445,"openaccessinfo":{"externalids":{"MAG":"2322104366","ACL":null,"DOI":"10.14288\/1.0088102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nPosttraumatic stress disorder (PTSD) is an anxiety disorder resulting from exposure to traumatic events. The Posttraumatic Stress Disorder Checklist (PCL) is a self-report measure largely used to evaluate the presence of PTSD.\n\n\nOBJECTIVE\nTo investigate the internal consistency, temporal reliability and factor validity of the Portuguese language version of the PCL used in Brazil.\n\n\nMETHODS\nA total of 186 participants were recruited. The sample was heterogeneous with regard to occupation, sociodemographic data, mental health history, and exposure to traumatic events. Subjects answered the PCL at two occasions within a 15 days' interval (range: 5-15 days).\n\n\nRESULTS\nCronbach's alpha coefficients indicated high internal consistency for the total scale (0.91) and for the theoretical dimensions of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) (0.83, 0.81, and 0.80). Temporal reliability (test-retest) was high and consistent for different cutoffs. Maximum likelihood exploratory factor analysis (EFA) was conducted and oblique rotation (Promax) was applied. The Kaiser-Meyer-Olkin (KMO) index (0.911) and Bartlett's test of sphericity (\u03c7\u00b2 = 1,381.34, p < 0.001) indicated that correlation matrices were suitable for factor analysis. The analysis yielded three symptom clusters which accounted for 48.9% of the variance, namely, intrusions, avoidance, and numbing-hyperarousal.\n\n\nCONCLUSION\nOur findings provide additional data regarding the psychometric properties of the PCL, including internal consistency, test-retest reliability, and factor validity. Results are discussed in relation to PTSD theoretical models.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":261246704,"openaccessinfo":{"externalids":{"MAG":"2000320566","ACL":null,"DOI":"10.1590\/S2237-60892012000400007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We examine the effect on the dc resistivity of small-q electron-phonon scattering, in a system with the electronic topology of the high-Tc oxides. Despite the fact that the scattering is dominantly forward, its contribution to the transport can be significant due to \"undulations\" of the bands in the flat region and to the umpklapp process. When the extended van Hove singularities are sufficiently close to EF, the acoustic branch of the phonons contribute significantly to the transport. In that case one can obtain linear T-dependent resistivity down to temperatures as low as 10 K, even if electrons are scattered also by optical phonons of about 500 K as reported by Raman measurements.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250734321,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1209\/epl\/i1998-00248-2","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arxiv.org\/pdf\/cond-mat\/9705085","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Celosia argentea (CA) is used in traditional medicine for sores, ulcers, and skin eruptions. The present study was aimed at investigating the healing efficacy of CA extract in an ointment formulated (10\u2003% w\/w) as an alcohol extract of CA using a rat burn wound model. Wound closure occurred earlier in the treated rats (15\u2003days vs. 30 in the untreated group; p\u2003<\u20030.05). Granulation tissue collected on every fifth day of healing showed an increase in collagen and hexosamine content at a faster rate in the treated wounds. This correlated with the accelerated wound closure observed in the treated groups. To probe the cellular basis of this effect, we investigated the effect of this extract on two major cellular responses; cell proliferation and cell motility, in two key cell lineages, fibroblasts and keratinocytes. CA was not toxic at concentrations of < 3\u2003\u00b5g\/ml in fibroblasts and < 30\u2003\u00b5g\/ml in keratinocytes. The alcohol extract promoted cell motility and proliferation of primary dermal fibroblasts at 0.1\u20131.0\u2003\u00b5g\/ml but did not alter these responses in primary keratinocytes. In an initial examination of molecular mechanisms, we found that the CA extract did not alter fibroblast and keratinocyte responses to the wound repair\u2010associated epidermal growth factor receptor ligands. In short, we demonstrate a salutary action of the CA extract on wound healing, and suggest that this may be due to mitogenic and motogenic promotion of dermal fibroblasts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23312017,"openaccessinfo":{"externalids":{"MAG":"2037918644","ACL":null,"DOI":"10.1111\/j.1067-1927.2004.12603.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Grid computing has emerged as an important new field wherein the focus lies on resource sharing, innovative applications, and high-performance orientation. Computational Grid can be defined as large-scale high-performance distributed computing environments that provide access to high-end computational resources. Since the grid is a vast array of resources, monitoring of the grid is essential to improve debugging facilities and performance enhancement. Monitoring system must be able to provide information about the current state of various grid entities such as grid resources and running jobs as well as to provide notifications when certain important events occur. In this paper we provide a status monitoring system, which keeps track of the percentage of the job completed. It computes the time completed as a percentage of the total execution time of the job. The estimated run time of job is calculated using Performance Prediction. It uses Priority based Algorithm for global scheduling and Levelized Weight Tuning technique for local scheduling the jobs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-06":1,"unknown":2}},"corpusid":13554717,"openaccessinfo":{"externalids":{"MAG":"2163889648","ACL":null,"DOI":"10.1109\/ADCOM.2006.4289864","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The energetics of the long duration GRB phenomenon is compared with models of a rotating Black Hole (BH) in a strong magnetic field generated by an accreting torus. A rough estimate of the energy extracted from a rotating BH with the Blandford-Znajek mechanism is obtained with a very simple assumption: an inelastic collision between the rotating BH and the torus. The GRB energy emission is attributed to an high magnetic field that breaks down the vacuum around the BH and gives origin to a e \u00b1 fireball. Its subsequent evolution is hypothesised, in analogy with the in-flight decay of an elementary particle, to evolve in two distinct phases. The first one occurs close to the engine and is responsible of energising and collimating the shells. The second one consists of a radiation dominated expansion, which correspondingly accelerates the relativistic photon\u2013particle fluid and ends at the transparency time. This mechanism simply predicts that the observed Lorentz factor is determined by the product of the Lorentz factor of the shell close to the engine and the Lorentz factor derived by the expansion. An anisotropy in the fireball propagation is thus naturally produced, whose degree depends on the bulk Lorentz factor at the end of the collimation phase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119486321,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1046\/j.1365-8711.2003.06352.x","PubMedCentral":null,"ArXiv":"astro-ph\/0112432"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/astro-ph\/0112432v1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The increasing number of reported child abuse cases in Malaysia is alarming, with more than 1000 cases reported every year. If this trend continues, it may have detrimental effects on children's mental development, and far-reaching negative effects for wider society. Examining whether there is some relationship between divorce, unemployment, poverty, inflation, economic growth, and child abuse in Malaysia may help shed some light on the issue and any potential solutions. This study employs the ARDL approach by using data from 1989 to 2019. The results reveal that unemployment, inflation, and economic growth have significant relationships with reported child abuse cases in the long run. However, divorce and poverty do not affect the number of reported child abuse cases in the long run. In the short run, the results show that divorce, economic growth, and unemployment can positively affect the number of reported child abuse cases. Poverty, on the other hand, has a significant and negative relationship with the number of reported child abuse cases in the short run. Family stress originating from economic and social distress and the potential inability of couples to manage stress may exacerbate the risk of child abuse in Malaysia. Social programs are likely needed to help couples handle stress at home, in the form of state-sponsored counselling, educational programs for parents, the provision of social support for an increasing number of dual-career couples, assistance for spouses dealing with divorce, and the protection of children from hostile environments at home, as well as general approaches to the alleviation of poverty.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":253833367,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/economies10110291","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2227-7099\/10\/11\/291\/pdf?version=1669027503","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":":In India agriculture was traditionally organic till the 1950. The green revolution was ushered in country during sixty and transformed the stage of food deficiency to self-sufficiency. Fertilizers no doubt increased the quantity of yield and reduced diseases but continuous use of chemical fertilizers causes several side effects on soil. Soil becomes hard and impervious to water. Maintenance of soil fertility is now prerequisite. Organic farming is the solution. There are several organic components which are the good source of organic manure. Weed biomass available abundantly. Weeds are considered as unwanted plants and are competitors to the crop plants. There are several methods to control the weed. The best way to control weed is to make use of it. Ipomoea muricata (L). Jacq. is large herbaceous twiner commonly called as Bhowari in Marathi. It is common weed grow luxuriously on waste land. Present investigation deals with utilization of Ipomoea muricata weed as a source of organic manure and its influence on the aerial biomass of maize. various types of Ipomoea muricata weed manures like Compost, Dry Leaf manure, Green Leaf manure, Mixed manure (equal amount of Ipomoea muricata +Euphorbia prunifolia+Trianthema portulacastrum) are prepared and compared with NPK and Control treatment to maize crop field. Crop was harvested after 87 days of sowing. Samples from each treated plots collected and analysed as total aerial biomass, Dry weight, Reducing Sugar, Nitrogen, Crude protein and nitrogen efficiency ratio. All the nutrient contents show high amounts in weed manure amended samples of Maize as compared to NPK and control treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251581391,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Articles dealing with industrial management decision-making generally rely on a cost system to establish a global indicator and identify the best solution. Cost accounting is based on a number of assumptions as to production system operation that may be quite remote from those used in decision modelling. Our paper points out the origin of this inconsistency and that it may lead to irrelevant decisions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14977334,"openaccessinfo":{"externalids":{"MAG":"2785661701","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The case history of a male patient, 62 years old, in preterminal uremia at transplantation with a cadaveric kidney is described. Twelve years before the transplantation he was operated on because of an aortic aneurysm where the abdominal aorta and both iliac arteries were substituted with a Dacron prosthesis. The kidney was anastomosed to this vessel substitute and functioned excellently for more than five years and the patient was completely rehabilitated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8161162,"openaccessinfo":{"externalids":{"MAG":"1976372136","ACL":null,"DOI":"10.3109\/00365597909180015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Several experiments have reported evidence for the \u03c01(1400) using pion production but the results have been controversial and its existence has yet to be seen in photoproduction. Theoretical works have implied that the production amplitude will be greatly increased in photoproduction in comparison to the pion production. The reaction \u03b3p\u2192\u039b++X\u2192p\u03c0+\u03c0\u2212(\u03b7) is being studied in the photon energy range 4.4 to 5.4 GeV as a possible method of producing the \u03c01(1400) resonance. Data were collected at Jefferson Lab in Hall B. This reaction is being investigated by detecting the p\u03c0+\u03c0\u22122\u03b3 and reconstructing the \u03b7 through the missing\u2010mass of the p\u03c0+\u03c0\u2212, and comparing the results to the 2\u03b3 composite. These data have yielded a0(980) and a2(1320) in the \u03c0\u2212\u03b7 invariant mass spectrum. Further analysis is needed to untangle the possible \u03c01(1400) resonance from the a2(1320).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":116541705,"openaccessinfo":{"externalids":{"MAG":"2107159544","ACL":null,"DOI":"10.1063\/1.3483378","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1063\/1.3483378","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"A novel marine sulfate-reducing bacterium, strain CV2803T, which is able to oxidize aliphatic hydrocarbons, was isolated from a hydrocarbon-polluted marine sediment (Gulf of Fos, France). The cells were rod-shaped and slightly curved, measuring 0.6x2.2-5.5 microm. Strain CV2803T stained Gram-negative and was non-motile and non-spore-forming. Optimum growth occurred in the presence of 24 g NaCl l(-1), at pH 7.5 and at a temperature between 28 and 35 degrees C. Strain CV2803T oxidized alkanes (from C13 to C18) and alkenes (from C7 to C23). The DNA G+C content was 41.4 mol%. Comparative sequence analyses of the 16S rRNA gene and dissimilatory sulfite reductase (dsrAB) gene and those of other sulfate-reducing bacteria, together with its phenotypic properties, indicated that strain CV2803T was a member of a distinct cluster that contained unnamed species. Therefore, strain CV2803T (=DSM 15576T=ATCC BAA-743T) is proposed as the type strain of a novel species in a new genus, Desulfatibacillum aliphaticivorans gen. nov., sp. nov.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14346105,"openaccessinfo":{"externalids":{"MAG":"2171770091","ACL":null,"DOI":"10.1099\/IJS.0.02717-0","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As a novel post-harvesting strategy, edible films and coatings for fruits and vegetables offer preservation measures to meet the growing needs of hunger and agricultural management. The functionality of edible films and coatings is distinctly the same. However, edible films and coatings differ in their processing and physicomechanical characteristics as they are designed to improve the shelf life, barrier, and nutritional properties of the food. With emerging concerns about sustainability, biomacromolecules have been widely considered in preparing edible films and coatings, which are Generally Recognized as Safe (GRAS) substances. Biopolymers, including polysaccharides, proteins, and lipids, are the main sources of preparing edible films and coatings. These biomacromolecules make stable colloidal dispersions that deliver processing convenience with various formulation, blending, casting, coating, and film-forming methods. Edible films and coating from biopolymers require improvements for their extended performance due to several structural and barrier limitations. Therefore, preparing blends and composites, incorporating target molecules to introduce different functionalities, and designing complex multilayers are among the many recent research approaches developed to overcome those limitations. These recent research approaches ensure enhanced food preservation and extended shelf life, essential requirements of food waste management, with or without minimal influence on the texture, flavor, and nutritional value of food and vegetables. This review focuses on the recent developments in edible films and coatings for fruits and vegetables. Furthermore, this review includes characteristics and functionalities, processing, structural and chemical significance, different sources and their performances, health effects, and recent trends related to edible films and coatings.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259712229,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/coatings13071177","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2079-6412\/13\/7\/1177\/pdf?version=1688109217","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Animals that have been exposed to a very low dose of radiation are known to have many physiological benefits. Very low dose of ionizing radiation also induces mechanisms whereby cell or tissue become better fit to cope with subsequent exposures of high doses. This phenomenon of low dose radiation is termed 'adaptive response'. This response has been reported to be true in many biological systems and confirmed by experiments on chromosomal and chromatid aberrations, micronucleus formation, sister chromatid exchange tests, DNA mutation and cell survival study and using many other biological end points, although there are quite a few exceptions. The adaptation induced by low doses of radiation has been attributed to the induction of an efficient chromosome break repair mechanism at molecular and biochemical level. It is also substantiated in whole animal systems. When mice are initially conditioned with very small adapting doses, incidence of a challenging dose induced thymic lymphoma is recorded, with delayed latency and reduced frequency. Similarly, appearance of a transplanted barcl-95 thymic tumor has been delayed when mice are preconditioned with a small dose of radiation. Appearance and development of a tumour following transplantation of in vitro irradiated barcl-95 tumour cells with a small dose of 1 cGy are also delayed and volume of the tumour is reduced. Latency period of radiation-induced leukemia is modified by prior treatment with an adapting dose of radiation. Neoplastic transformation of several human cultured cells is also significantly decreased by prior low dose exposure of radiation compared to non-exposed cells. These results indicate that an earlier exposure to a small dose of radiation also reduces the radiation-induced carcinogenesis. Various aspects of molecular mechanism underlying the radio-adaptation have been explained. However, the mechanism underlying the inhibition of carcinogenesis by low dose radiation is yet to be fully resolved.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31835944,"openaccessinfo":{"externalids":{"MAG":"2423203177","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The high squint diving SAR is widely used to provide the information in advance. Large squint angle deduces the deeper coupling of range and azimuth of SAR echoes which makes SAR imaging more di-cult. Especially, the large range migration of the deep couple heavily burdens the imaging processing time and storage units. The diving motion of platform worsens the situation. This paper proposes the varied azimuth sample frequency (Pulse Repeat Frequency, PRF) to implement the high squint diving SAR imaging. Based on the signal model of the diving squint SAR, it is analyzed that the range walk is the prominent component of range migration in the high squint SAR. The varied PRF imaging method dramatically decreases the range walk of echoes by shifting the beginning position of transmitted pulses and received echoes and the shift is implemented by the PRF variation. Then the range migration is decreased and the couple of range and azimuth of SAR echoes is reduced. The PRF variation law is deduced and the applicable condition of varied PRF is presented. The simulation results show that the variable PRF method is e-cient to reduce range walk of echoes. Comparison to the traditional constant PRF, the novel variable PRF method for high squint needs less storage and less time expense, which is helpful to real time SAR imaging. The non-uniform FFT can be used for the azimuth compressing of the variable PRF SAR. It will simplify the implementation of the variable PRF SAR imaging.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":16993198,"openaccessinfo":{"externalids":{"MAG":"2083899170","ACL":null,"DOI":"10.2528\/PIER12112304","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Soil from steppe and garden reserves, and urban park and wharf regions in the Ukraine, U.S.S.R., were studied for keratinophilic as well as for other predominant micro-fungal species. Most of the fungi were nonpathogens, and potential skin infecting fungi were limited to Microsporum gypseum and Trichophyton ajelloi. Species diversity identified population variation between collection sites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12592239,"openaccessinfo":{"externalids":{"MAG":"2414825466","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the rapid developments of information technologies, distance education programs in library and information science are increasing across the world. Instructors play very important roles in providing high quality instruction for students. Given this climate, this article briefly compares the traditional education with distance education and discusses the instructor's roles from multiple perspectives. The related literature is reviewed, which results in the recommendation that instructors should prepare for and perform multiple roles while teaching. Only when much more importance is attached to multiple roles in distance education by instructors themselves, administrators, and accreditors can the quality of distance education, assessment and evaluation be effectively improved in the future. Instructors who are accustomed to delivering lectures in face-to-face classrooms and will teach online should have a good mastery of the multiple teaching roles transformation, be very clear about what roles and responsibilities they should have in distance education, and have the corresponding changing role-related skills and competencies in order to provide the high quality teaching for distance learners.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":64574475,"openaccessinfo":{"externalids":{"MAG":"2738149577","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Molecular imprinting, a technique that allows for preparation of adsorbents with sites tailored for recognition of a particular molecule, continues to grow because it holds promise for several areas including separations. A key fundamental aspect in forming a molecular imprinted polymer (MIP) is the ability to optimize the amount of functional monomer relative to template used for the polymerization. In this paper, isothermal titration calorimetry (ITC) was used to predict the optimum functional monomer concentration for preparing an MIP for the drug, cinchonidine. Calorimetric titrations of cinchonidine with the functional monomer, methacrylic acid, suggested that a methacrylic acid\u2013cinchonidine hydrogen bonded complex of minimum energy exists for solutions of 4:1 mol\/mol of the monomer relative to the template. When this ratio of functional monomer to template was utilized for the MIP synthesis, the resulting polymer displayed significantly better selectivity for cinchonidine than polymers prepared with lesser or greater amounts of methacrylic acid. This observation is explained in terms of a balance that was achieved in the monomer\u2013template equilibrium during the polymerization. This balance maximizes the favorable hydrogen bonding interactions with the template during the polymerization that yields the selective sites, but minimizes the use of excess monomer, which leads to non\u2010selective sites on the polymer. The results within suggest that ITC can be a valuable tool in the syntheses of MIPs.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97918831,"openaccessinfo":{"externalids":{"MAG":"2046841163","ACL":null,"DOI":"10.1081\/JLC-200038551","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SARS-CoV-2 may be the greatest challenge that modern society (and modern medicine) has faced. The epidemiological characteristics of SARS-CoV-2 and its global impact will focus attention on all facets of medicine. Early evidence shows that SARS-CoV-2 initially infects alveolar epithelium and associated macrophages. Thus, a potential strategy to bring medicinals into close contact with infecting virus is to target nano-structures via inhalation; a factor in considering nano-therapeutic design being their localization to the tissues and cells of the alveoli. Strategies that target intracellular pathways utilized by ligand-directed nano-therapeutics appear to potentially have efficacy, focusing upon signalling mechanisms that activate endocytotic pathways that are also utilized by SARS-CoV when infecting cell targets. Foci of the present paper are the retrograde cellular transport pathways that direct proteins \/ peptides to the endoplasmic reticulum (ER). Speculation in this perspective identifies multiple sub-cellular compartments at which nano-structure-delivered anti-virals may intersect those utilized by SARS-CoV-2 (and other RNA viruses). These include endocytosis pathways, points of viral entry to cells and sites of viral assembly. In the context of development of anti-virals against SARS-CoV-2, the discussion here provides stimulus for scientific debate. In bringing the context of nano-therapeutic design together with the very preliminary knowledge of the patho-physiology of SARS-CoV-2, it is hoped that this perspective is useful.\n\n[READ ARTICLE](https:\/\/precisionnanomedicine.com\/article\/12680)","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":219027724,"openaccessinfo":{"externalids":{"MAG":"3021509596","ACL":null,"DOI":"10.33218\/001c.12680","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/precisionnanomedicine.com\/article\/12680.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this research were evaluates the change microestructural that presents the steel AISI - SAE 4140 to the subjected being to conditions of continuous cooling with the purpose of analyzing the transformation bainitica. It was determined that the microestructura at distances of 0.2 at 2mm is martensitico and at distances bigger than 30mm a behavior bainitico was observed. The type of opposing bainita was of the nodular or globular type.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":138161719,"openaccessinfo":{"externalids":{"MAG":"2140707757","ACL":null,"DOI":"10.22517\/23447214.4867","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose To report a young patient with choroidal neovascularization (CNV) secondary to Best vitelliform macular dystrophy (BVMD) who recovered good visual acuity with intravitreal bevacizumab (IVB). Methods A 6-year-old boy was noted to have diminution of vision in both eyes. His best-corrected visual acuity (BCVA) was 20\/40 in the right eye (OD) and 20\/160 in the left eye (OS). Detailed examination including slit-lamp biomicroscopy, fluorescein angiography, and optical coherence tomography (OCT) showed active CNV in OS. Two consecutive IVB injections (1.25 mg\/0.05 mL) were given in OS. Results During the follow-up, OD showed minimal subretinal fluid on OCT and was treated with one injection of IVB (1.25 mg\/0.05 mL). At 9 months of follow-up, OS BCVA was 20\/50 and OD BCVA 20\/30 with presence of scarred CNV on fundus examination and OCT in both the eyes. No drug-related ocular or systemic side effects were encountered. Conclusions Intravitreal bevacizumab appears to be a promising and cost-effective modality of treatment in CNV associated with BVMD with good visual recovery.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35713019,"openaccessinfo":{"externalids":{"MAG":"1971001182","ACL":null,"DOI":"10.5301\/ejo.5000095","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Rare headache syndromes that are so fare not yet admitted to the classification system of the International Headache Society are the SUNCT syndrome (short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing), the hemicrania continua and the red ear syndrome. The clinical characteristics, differential diagnoses and therapeutic strategies of these pathophysiologically unclarified diseases are presented with three casuistic reports.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41430983,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Previous research has demonstrated the utility of using lag schedules of reinforcement to increase response variability of children with autism. However, little research has evaluated whether the lag schedule promotes variability from within an already-established repertoire or expands the current repertoire by promoting the use of new responses (i.e., those not previously demonstrated). Thus, the purpose of the current study was to evaluate the extent to which lag schedules of reinforcement produced already-established intraverbal responses or novel responses for 3 children with autism. Results showed that lag schedules alone were sufficient to increase the number of different responses emitted for 2 participants, whereas brief variability training was needed for 1 participant. Further, some participants emitted novel responses throughout the experiment, suggesting that lag schedules may be an effective method for expanding a response class.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10996188,"openaccessinfo":{"externalids":{"MAG":"2221016035","ACL":null,"DOI":"10.1002\/jaba.271","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract \nThis is a conceptual paper. I argue that knowledge-construction, or learning in a profession, has changed with the introduction of professional doctorates, though the divide between these new forms of doctoral study and the older and more established forms such as the PhD are now not as wide as they once were. In particular, three elements of the knowledge-construction process are implicated here. The first of these is a move towards learning environments which prioritise situated-theoretical applications of the theory-practice relationship at the expense of technical-empiricist, technical-rational, multi-methodological and multi-discursive variants. The second is movement towards different sites of learning, so that instead of the knowledge-construction process taking place exclusively in universities or institutes of higher education, the workplace is now central to the construction of learning environments. And the third is the development of new types of knowledge-construction, and these are now acting to reframe relationships between the professions and the state. This has resulted in forms of deprofessionalisation, with some professions in the United Kingdom and other parts of the world experiencing significant losses of autonomy and independence in relation to ownership of their specialized bodies of knowledge and skills, control of the means for credentialising these bodies of knowledge, and renegotiated professional mandates, leading to restrictions on their capacity to determine for themselves these specialized bodies of knowledge and those learning environments in which practitioners acquire them.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":115062185,"openaccessinfo":{"externalids":{"MAG":"2504969054","ACL":null,"DOI":"10.1108\/S1479-362820140000013000","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"CD22 has been suggested to contribute to Alzheimer's disease (AD) pathogenesis by inhibiting microglial amyloid \u03b2 (A\u03b2) phagocytosis. Soluble CD22 (sCD22) generated by cleavage from cell membranes may be a marker of inflammation and microglial dysfunction; but alterations of sCD22 levels in AD and their correlation with AD biomarkers remain unclear. Plasma sCD22 levels were measured in cognitively normal non-AD participants and patients with preclinical AD and AD dementia from a Chinese cohort and the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Plasma sCD22 levels were elevated in patients with preclinical and dementia AD. Plasma sCD22 levels were negatively correlated with cerebrospinal fluid (CSF) A\u03b242 levels and A\u03b242\/A\u03b240, and positively correlated with CSF phosphorylated tau levels and brain A\u03b2 burden, but negatively correlated with cognitive function. Moreover, higher plasma sCD22 levels were associated with faster cognitive decline during follow-up. These findings suggest that CD22 plays important roles in AD development, and that sCD22 is a potential biomarker for AD.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247865793,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1126\/sciadv.abm5667","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background The clinical diagnosis of Huntington's disease (HD) is based on motor symptoms, although these can be preceded by cognitive changes. However, it is still difficult to predict the clinical onset of HD based on neuropsychological tests. Increasingly, social cognition impairments have been found in HD patients. In recent studies, social cognition has been put forward as possible predictor of the clinical diagnosis in premanifest HD patients. Aims The aim of the present study was to assess whether impairments in social cognition might be a more sensitive predictor of the onset of the disease than non-social cognitive impairments. Therefore we wanted to assess whether impairments in social cognition preceded deterioration of general cognitive functions in premanifest gene carriers and whether social cognition was related to non-social cognition measures in a group of premanifest and manifest HD patients. Methods\/Techniques A cohort of 14 premanifest gene carriers of HD and 40 manifest HD patients were assessed on psychomotor speed, executive functioning, verbal and categorical fluency and emotion recognition. Results\/outcome In the premanifest stage, patients did not have lower scores on emotion recognition as compared to general cognitive tasks. In the manifest group and combined group correlations were found between social and non-social cognition tasks, but this was not found in the premanifest group. Conclusions Overall, disease progression seems to affect both social and non-social cognition equally. Based on the present study social cognition is unlikely to be indicative in the premanifest stage for conversion to the manifest stage of HD.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":81873031,"openaccessinfo":{"externalids":{"MAG":"2897301544","ACL":null,"DOI":"10.1136\/jnnp-2018-EHDN.140","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A single bifurcation with adjustable branch compliances, resistances and inertances was used to study the generation of pendelluft flows during ventilation at tidal volumes of 5-15 ml and frequencies of 6-26 Hz, corresponding to parent branch Reynolds numbers of 400-8000 and Womersley parameter values of 12-25. Pendelluft was quantified by the ratio of tidal volume sum in sibling branches to tidal volume in the parent branch. This tidal volume fraction being greater than one in all experiments where an asymmetry in branch mechanics was imposed, indicated that some degree of pendelluft was always present. Asymmetries in compliance and in inertance produced much greater pendelluft than an asymmetry in resistance. The largest tidal volume fraction, equal to 2.75, was recorded when inertance in both sibling branches was high, resistance was low, and compliances differed by a factor of five. Tidal volume fraction always peaked at an optimal frequency between 12-24 Hz, similar to the frequencies at which physiologic transport optima have previously been observed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30738777,"openaccessinfo":{"externalids":{"MAG":"2048323425","ACL":null,"DOI":"10.1115\/1.2894893","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of the study was to investigate how Non- Pharmacological Techniques (NPT), in addition to standard pharmacological techniques, can help to manage and reduce the preoperative anxiety of children waiting for Day Surgery procedures (DS). Isola Serena activity started in 2008 to manage the preoperative time of children waiting for surgery in the playing room. The latter is run by a pedagogist. NPT includes use of games and toys, readings and drawings. A descriptive and comparative study was conducted on 50 children, aged 4 to 12 years, randomly assigned to Isola Serena group ISG and control group CG. All children received standard pharmacological techniques, while those of the ISG also received the NPT. The evaluation of the preoperative anxiety level (modified Yale Preoperative Anxiety Scale) and parent's coping style (Coping Inventory for Stressful Situation) compared the two groups. The ISG showed a significantly lower level of preoperative anxiety than the CG. Parents' coping style was not related to the preoperative anxiety. The activity performed in the Isola Serena Project resulted to be effective for the reduction of preoperative anxiety in children undergoing DS procedures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232304304,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4081\/pmc.2021.235","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.pediatrmedchir.org\/pmc\/article\/download\/235\/273","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The general principles of the geology of water which were developed during the late nineteenth and early twentieth century are still valid but, in many instances, are still ignored, misunderstood, and misused not only by laymen but by engineers and geologists. Meinzer, on the basis of his and many other investigators* work, clearly and accurately described the types of water and their origin; the movement and occurrence of ground water; the close relationship between soil water, surface water, and ground water; and the development and other economic aspects of ground water. His work was based on a conservative but sound knowledge and deep understanding of geological phenomena and principles. Meinzer was also chiefly responsible for initiation and support of those quantitative studies of a primarily mathematical and engineering nature which are the chief basis for present-day evaluation of ground water supplies. Concurrently, many other workers were collecting and interpreting facts and formulating ideas bearing on the areas of surface water and soil moisture. This work was done primarily by engineers, physicists, and pedologists and was not always based on sound geologic thinking\u2014indeed, it was often conducted in ignorance of geologic fact and principle. Recent progress by later workers in clarifying, refining, amplifying and applying these principles has been impressive and has resulted in broader, more accurate understanding of them. However, many problems still remain to be solved and the responsibility of the geologist in water resources studies has increased rather than lessened. Actually, the advances in quantitative studies following the introduction of methods based on the Theis non-equilibbrium formula, the theory of image wells, relaxation and other numerical analysis methods, flow nets, and various analogs have tremendously increased the need and have justified expenditure for highly detailed and definitive geologic information. Undoubtedly this need will increase rather than slacken in the next few decades for the economic expansion of our national life demands far more efficient conservation and development of water resources than has heretofore been practiced. The petroleum industry uses large quantities of water for industrial and domestic purposes. Thus, it faces supply and distribution problems similar to those of other industries. Unique hydrologic problems are encountered in the practice of secondary recovery of oil which is most commonly accomplished by water-flooding. The most efficient and successful water-flooding project requires an adequate supply of water of a quality that is compatible with the formations into wlrch it is to be injected. These formations are not very permeable as compared with the water-supply aquifers which are frequently re","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110370264,"openaccessinfo":{"externalids":{"MAG":"2185480993","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During maintenance, software developers deal with numerous change requests that are written in an unstructured fashion using natural language. Such natural language texts illustrate the change requirement involving various domain related concepts. Software developers need to find appropriate search terms from those concepts so that they could locate the possible locations in the source code using a search technique. Once such locations are identified, they can implement the requested changes there. Studies suggest that developers often perform poorly in coming up with good search terms for a change task. In this paper, we propose a novel technique-STRICT-that automatically identifies suitable search terms for a software change task by analyzing its task description using two information retrieval (IR) techniques-TextRank and POSRank. These IR techniques determine a term's importance based on not only its co-occurrences with other important terms but also its syntactic relationships with them. Experiments using 1,939 change requests from eight subject systems report that STRICT can identify better quality search terms than baseline terms from 52%\u201362% of the requests with 30%\u201357% Top-10 retrieval accuracy which are promising. Comparison with two state-of-the-art techniques not only validates our empirical findings and but also demonstrates the superiority of our technique.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":12407586,"openaccessinfo":{"externalids":{"MAG":"2964240520","ACL":null,"DOI":"10.1109\/SANER.2017.7884611","PubMedCentral":null,"ArXiv":"1807.04475"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work describes a general method for the synthesis of oligoribonucleotides containing a site-specific nonbridging phosphorodithioate linkage via automated solid-phase synthesis using 5'-O-DMTr-2'-O-TBS-ribonucleoside 3'-N,N-dimethyl-S-(2,4-dichlorobenzyl) phosphorothioamidites (2a-2d). The 3'-phosphorothioamidites (2a-2d) can be conveniently prepared in good yields (86-99%) via a one-pot reaction from the corresponding 5'-O-DMTr-2'-O-TBS-ribonucleosides (1a-1d).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21617372,"openaccessinfo":{"externalids":{"MAG":"2020144991","ACL":null,"DOI":"10.1021\/jo301834p","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3500914?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Abstract Antimicrobial resistance (AMR) continues to spread at an alarming rate worldwide. Novel approaches are needed to mitigate its deleterious impact on antibiotic efficacy. Antibiotic stewardship aims to promote the appropriate use of antibiotics through evidence-based interventions. One paradigm is precision medicine, a medical model in which decisions, practices, interventions, and therapies are adapted to the individual patient based on their predicted response or risk of disease. Precision medicine approaches hold promise as a way to improve outcomes for patients with myriad illnesses, including infections such as bacteraemia and pneumonia. This review describes the latest advances in precision medicine as they pertain to antibiotic stewardship, with an emphasis on hospital-based antibiotic stewardship programmes. The impact of the COVID-19 pandemic on AMR and antibiotic stewardship, gaps in the scientific evidence, and areas for further research are also discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249921638,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/jacamr\/dlac066","PubMedCentral":"9209748","ArXiv":null},"license":"CCBYNC","url":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/4\/3\/dlac066\/44159605\/dlac066.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A low matter density decaying vacuum cosmology is proposed on the assumption that the universe's radius is a complex quantity if it is regarded as having a zero energy - momentum tensor. But we find that when the radius is real, it contains matter. Using the Einstein - Hilbert action principle, the physical scale factor is obtained as equal to with representing the finite radius of the universe at t = 0. The resulting physical picture is roughly a theoretical justification of the old Ozer - Taha model. The new model is devoid of all cosmological problems. In particular, it confirms the bounds on , the present value of the Hubble parameter: and faces no age problem. We argue that the total energy density consists of parts corresponding to relativistic\/non-relativistic matter, a positive vacuum energy, a negative energy and a form of matter with equation of state (textures or generally K-matter), and the following predictions are made for the present non-relativistic era: , , , where a parameter corresponding to K-matter is taken to be unity. It is shown that spacetime with a complex metric has signature changing properties. Using quantum cosmological considerations, it is shown that the wavefunction is peaked about the classical contour of evolution and the minimum radius of the non-singular model is predicted as comparable with the Planck length.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119481918,"openaccessinfo":{"externalids":{"MAG":"2046016767","ACL":null,"DOI":"10.1088\/0264-9381\/14\/5\/016","PubMedCentral":null,"ArXiv":"gr-qc\/0007052"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/gr-qc\/0007052","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Extra-abdominal fibromatosis is an uncommon benign breast lesion resembling an infiltrative carcinoma in its clinical and radiological presentation. Surgical excision with wide margins remains the treatment of choice to avoid recurrence of this locally aggressive tumor. We present a case in which surgical biopsy allowed the diagnosis of a breast fibromatosis and we discuss its clinical, diagnostic, pathological and therapeutic particularities. 2009 Elsevier Masson SAS. All rights reserved. Mots cl\u00e9s : Chirurgie ; Fibromatose extra-abdominale ; Imagerie du sein ; L\u00e9sions b\u00e9nignes ; Microbiopsie","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7784353,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The calculation of both resistive and ideal plasma equilibria amounts to solving a number of magnetic differential equations which are of the type $\\vec {B}\\cdot \\nabla \\Phi =s$. We apply the necessary and sufficient criterion for the existence of the potential $\\Phi$ and find that a static equilibrium configuration of a magnetically confined plasma does not exist in axi-symmetric toroidal geometry.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119477051,"openaccessinfo":{"externalids":{"MAG":"1880391280","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"physics\/0510140"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The well-known issue of reconstructing regulatory networks from gene expression measurements has been somewhat disrupted by the emergence and rapid development of single-cell data. Indeed, the traditional way of seeing a gene regulatory network as a deterministic system affected by small noise is being challenged by the highly stochastic, bursty nature of gene expression revealed at single-cell level. In previous work, we described a promising strategy in which network inference is seen as a calibration procedure for a mechanistic model driven by transcriptional bursting: this model inherently captures the typical variability of single-cell data without requiring ad hoc external noise, unlike ordinary or even stochastic differential equations often used in this context. The resulting algorithm, based on approximate resolution of the related master equation using a self-consistent field, was derived in detail but only applied as a proof of concept to simulated two-gene networks. Here we derive a simplified version of the algorithm and apply it, in more relevant situations, to both simulated and real single-cell RNA-Seq data. We point out three interesting features of this approach: it is computationally tractable with realistic numbers of cells and genes, it provides inferred networks with biological interpretability, and the underlying mechanistic model allows testable predictions to be made. A practical implementation of the inference procedure, together with an efficient stochastic simulation algorithm for the model, is available as a Python package.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":238226619,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2109.14888"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Thoriated electrodes are used in TIG welding. TIG welders, along with persons who grind thoriated electrodes and persons located near relevant welding and grinding sites, might be at risk of thorium intake. The isotopes of radiological relevance are 232Th, 230Th, and 228Th. The studies described in the literature do not provide a consistent picture of the actual hazards, and changes in European and German radiological protection laws have now made it necessary to determine the risks. To accomplish this, a field test was conducted under real working conditions in 26 different welding shops. The airborne activity generated through welding, and through grinding of electrodes, was measured using personal air samplers. Stationary samplers were also used. The filters' samples were evaluated by means of direct alpha spectrometry with proportional counting and by means of gamma spectrometry following neutron activation. The results clearly showed that considerable intake can occur during both alternating-current welding and electrode grinding, if no suction systems are used. The range of 232Th intakes to welders were estimated from 0.1 Bq y(-1) to 144 Bq y(-1) during welding and from 0.02 Bq y(-1) to 30.2 Bq y(-1) during grinding. In 6 of the 26 cases the recent annual limit on intake derived from the most recent ICRP publications was exceeded--in the worst case it was exceeded by a factor of 10--if it is assumed that the persons studied were not exposed workers (not routinely monitored for radiation exposure). When the significantly more restrictive German limits are applied, the amounts by which the limits were exceeded were even greater. Because many qualified welders have very long careers, the risks can thus be considerable. The paper also discusses parameters that influence exposure, and it presents a catalogue of recommended measures for dosage reduction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41839185,"openaccessinfo":{"externalids":{"MAG":"2063436341","ACL":null,"DOI":"10.1097\/00004032-199910000-00015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In order to directly demonstrate that in static gravitational field the rate of clocks increases with their distance from the source, a simple thought experiment is proposed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12782780,"openaccessinfo":{"externalids":{"MAG":"2072195171","ACL":null,"DOI":"10.1142\/S0217732300002310","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We first find a Hamiltonian H that has the Hurwitz zeta functions \u03b6(s,x) as eigenfunctions. Then we continue constructing an operator G that is self-adjoint, with appropriate boundary conditions. We will find that the \u03b6(s,x)-functions do not meet these boundary conditions, except for the ones where s is a nontrivial zero of the Riemann zeta, with the real part of s being greater than 1\/2. Finally, we find that these exceptional functions cannot exist, proving the Riemann hypothesis, that all nontrivial zeros have real part equal to 1\/2.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":198464654,"openaccessinfo":{"externalids":{"MAG":"2954275394","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Software process improvement is an obvious and logical way to address the increasing need to be competitive in the software industry. Consequently, software industry is more and more concerned about software process improvement (SPI). However, even when many organizations are motivated to improve their software processes, very few know how best to do so. Therefore, introducing software process improvement has been a path full of obstacles, leaving those who are involved in the improvement frustrated and more convinced than ever that they must continue doing their work as before. This paper shows the results analysis of implementing a software process improvement in the project management processes of fourth offices at a multinational organization. The process improvement was done by using a methodology which implements a smooth and continuous process improvement through the use of a multi-model environment as a reference model.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":13199230,"openaccessinfo":{"externalids":{"MAG":"1596369366","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In Brazil, knowledge on copepods of the order Siphonostomatoida dates back to the late 1800s, with the earliest record concerning parasitic copepods of fish. In contrast, the first record in Brazil of a copepod associated with an unknown marine invertebrate did not appear until 1988, with further studies on this copepod group occurring only during the last 15 years. The aim of this paper is to summarize the knowledge on the diversity of the siphonostome copepods, focusing on the associates of marine invertebrates, and to add new data on the distribution of known species and on the utilization of host species. Finally, an evaluation is carried out on the results and the effort expended during this period, and some objectives are proposed for improving the knowledge of the siphonostome copepods associated with marine invertebrates in Brazil.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":88917450,"openaccessinfo":{"externalids":{"MAG":"2545246308","ACL":null,"DOI":"10.11646\/ZOOSYMPOSIA.8.1.10","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, a new current-mode current-controlled universal filter with single input and three outputs is presented. The proposed circuit uses single-output current controlled conveyors (CCCIIs) and can simultaneously realize lowpass, bandpass and highpass filter functions all at high impedance outputs. Realization of notch and allpass responses does not require additional active elements. The circuit enjoys independent current-control of the parameters \u03c90 and \u03c90\/Q without disturbing the gains of the lowpass, bandpass and highpass filters. Both its active and passive sensitivities are low.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109943582,"openaccessinfo":{"externalids":{"MAG":"2052166887","ACL":null,"DOI":"10.1080\/00207210010013201","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"High-impedance faults (HIFs) on distribution systems create unique challenges to protection engineers. HIFs do not produce enough fault current to be detected by conventional overcurrent relays or fuses. A method for HIF detection based on the nonlinear behaviour of current waveforms is presented. Using this method, HIFs can be distinguished successfully from other similar waveforms such as nonlinear load currents, secondary current of saturated current transformers and inrush currents. A wavelet multi-resolution signal decomposition method is used for feature extraction. Extracted features are fed to an adaptive neural fuzzy inference system (ANFIS) for identification and classification. The effect of choice of mother wavelet is also analysed by investigating a large number of wavelet families. Various simulation results, which are obtained using an appropriate model, are summarised and efficiency of the proposed algorithm for dependable and secure HIF detection is determined.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":110724057,"openaccessinfo":{"externalids":{"MAG":"2100903621","ACL":null,"DOI":"10.1049\/IET-GTD:20070120","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The contact behavior of an abradable coating (Al-Si 6%) and a labyrinth seal tooth (stainless steel) in a turbo-engine application was studied as a function of the incursion depth parameter, during labyrinth seal\/abradable interaction. A controlled and a gradual increase of the labyrinth seal incursion (by step of 50 \u03bcm) is performed to obtain the chronological contact evolution under severe operating tribological conditions. The labyrinth seal\/abradable contact experiments were conducted on a dedicated test rig able to reach high contact speeds from 0 to 130 m.s\u22121. To complete contact forces measurement during tests, a suitable instrumentation (acoustic emission sensor, accelerometer, thermocouples, etc.) is developed and coupled as close as possible of the interaction area. The experimental results from the both severe tribological conditions are presented by an analysis of signals recorded during contact tests. Macrographic and micrographic rub-groove observations of post tests samples, coupled with recorded signals from the contact complete the Al-Si 6% behavior study. A wear process description using the third body approach has been proposed to sum up the whole tribological results. Two different varieties of particles production have been identified; a ductile and an adhering layer on the rub-groove bottom and pulverulent fine powder particles, thus providing two different kind of third body and two different material flows.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55380943,"openaccessinfo":{"externalids":{"MAG":"2474952279","ACL":null,"DOI":"10.1051\/MECA\/2015118","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We sought to determine whether a G\u2192A variant at position \u221230 of the \u03b2-cell promoter of the glucokinase (GCK) gene observed to be present more frequently in Japanese-American men with impaired glucose tolerance (IGT) than in Japanese-American men with normal glucose tolerance (NGT) is associated with impaired \u03b2-cell function. We studied 125 unrelated Japanese-American men (aged 46\u201374 years; mean 61 \u00b1 0.5) who were nondiabetic by a 75-g oral glucose tolerance test (OGTT) (65 had NGT and 60 had IGT). The presence of the \u221230 \u03b2-cell GCK gene promoter variant was determined by single-strand conformation polymorphism analysis. \u03b2-cell function was assessed using the ratio of the incremental response in immunoreactive insulin (IRI) to that of glucose during the first 30 min of the OGTT (\u0394 IRI[30 min\u22120 min]\/\u0394glucose[30 min\u22120 min]) performed at baseline and at 5 years of follow-up. \u03b2-cell function adjusted for basal IRI ([\u0394 IRI[30 min\u22120 min]\/\u0394 glucose[30 min\u22120 min]]\/basal IRI; the relative insulin response) was also evaluated. At baseline, the \u221230 \u03b2-cell GCK gene promoter variant was present in 15.4% of subjects with NGT vs. 38.3% of subjects with IGT (P < 0.01). Fasting IRI did not differ between groups. At baseline, \u0394IRI[30 min\u22120 min]\/\u0394glucose[30 min\u22120 min] was significantly lower in subjects with the promoter variant (57 \u00d7 10\u22129 to 95 \u00d7 10\u22129 to 95 \u00d7 10\u22129] vs. 77 \u00d7 10\u22129 [55 \u00d7 10\u22129 to 128 \u00d7 10\u22129]; median [interquartile range]; P < 0.01) as was the relative insulin response (0.97 [0.70\u20131.24] vs. 1.37 [0.95\u20132.03] l\/mmol; P < 0.0005). Similarly, at 5 years of follow-up, \u0394IRI[30 min\u22120 min]\/\u0394glucose[30 min\u22120 min] and the relative insulin response were significantly reduced in the group with the variant. In the subgroups of subjects with IGT at baseline, IGT at 5 years, and NGT at 5 years, the relative insulin response was significantly lower in those with the variant. We conclude that the \u221230 \u03b2-cell GCK gene promoter variant is associated with reduced \u03b2-cell function in middle-aged Japanese-American men and may contribute to the high risk of abnormal glucose tolerance in this population.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":83739286,"openaccessinfo":{"externalids":{"MAG":"1989718340","ACL":null,"DOI":"10.2337\/diab.45.4.422","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Quality of video transmitted over time-varying wireless channels relies heavily on the coordinated effort to cope with both channel and source variations dynamically. Given the priority of each source packet and the estimated channel condition, an adaptive protection scheme based on joint source-channel criteria is investigated via proactive forward error correction (FEC). With proactive FEC in Reed Solomon (RS)\/Rate-compatible punctured convolutional (RCPC) codes, we study a practical algorithm to match the relative priority of source packets and instantaneous channel conditions. The channel condition is estimated to capture the long-term fading effect in terms of the averaged SNR over a preset window. Proactive protection is performed for each packet based on the joint source-channel criteria with special attention to the accuracy, time-scale match, and feedback delay of channel status estimation. The overall gain of the proposed protection mechanism is demonstrated in terms of the end-to-end wireless video performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":58739085,"openaccessinfo":{"externalids":{"MAG":"1971422758","ACL":null,"DOI":"10.1117\/12.411539","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Dong, W.; Yang, Q.; Huang, X.; Chen, Y., and Sun, S., 2022. Development of underwater wireless sensor networks (UWSNs): Using MAC protocol with concurrent transmission based on slotted FAMA. Journal of Coastal Research, 38(1), 241\u2013248. Coconut Creek (Florida), ISSN 0749-0208. With the continuous development of ocean research in recent years, as an extension of terrestrial wireless sensor networks, underwater wireless sensor networks play an increasingly important role in ocean and coastal research. The handshaking efficiency in the traditional slotted floor acquisition multiple access (FAMA) is low. After a successful handshake, only one node is allowed to send data. Moreover, there are unnecessary back-off problems; thus, the channel utilization is low. Aiming at improving the shortcomings of the traditional slotted FAMA, this paper proposes a Medium Access Control protocol with concurrent transmission based on slotted FAMA (SFAMA-CT). The sending node uses the long propagation delay of the network to maintain a sending matrix according to the position information of the nodes in the propagation range. The value of each element of the sending matrix is determined by whether two nodes can simultaneously send data without collision. Then, the sending node determines whether it can choose to send in the DATA phase according to the number of received X Clear-To-Send (XCTS) packets (where \"X\" indicates a CTS packet intended for another node) and element information of the sending matrix. The proposed protocol has higher handshake efficiency and improves the concurrent transmission of the network compared to that of other protocols. The simulation results show that, compared to slotted FAMA and SFAMA-data train (DT), the throughput of SFAMA-CT is increased by approximately 115% and 20%, respectively. SFAMA-CT also has good performance in the end-to-end delay.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":245652116,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2112\/JCOASTRES-D-21-00085.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Smartphone-based disaster communication systems have been the topic of many recent studies. However, existing systems unrealistically assume that prior to a disaster, the required applications have been installed in the smartphones of all users. In disaster areas without Internet access, obtaining the software required for communications systems is difficult because application distribution platforms, such as Google Play, are web-based. In this paper, we present RecurShare, which is a novel application distribution system. The key idea of RecurShare is to be able to distribute applications without the Internet by running a web server that can be accessed using the default web browser and the tethering function of Android smartphones. We evaluated the feasibility of RecurShare experimentally and showed that RecurShare functions without problems on a variety of commercial devices. Also, user feedback suggests that RecurShare sufficiently guides users through the application distribution process in a manner that is easy to understand. Furthermore, we found that RecurShare can distribute itself at an exponential rate and that it can transmit files at speeds that are comparable to those of commonly used wireless communication systems.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":210153031,"openaccessinfo":{"externalids":{"MAG":"2999928250","ACL":null,"DOI":"10.18494\/sam.2020.2614","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.18494\/sam.2020.2614","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Introduction: The dual mobility cup (DMC) concept was proposed by Professor Gilles Bousquet in 1974. Its' aims were to prevent postoperative dislocation, restore the physiological range of motion of the hip, and reduce the stresses at the interface. Since it was created, this design has been modified multiple times to reduce the complication rate, improve implant survival, and expand the indications. Areas covered: The objective of this review is to discuss the advantages and disadvantages of this implant based on its 40-year history and also to propose a range of indications based on published results. This will provide surgeons with a complete overview of DMC. Expert commentary: Published studies on DMC confirm the low dislocation rate. Improvements made to DMC overtime have greatly reduced the complications related to wear, such as aseptic loosening and intraprosthetic dislocation (IPD). According to the literature, the indications have expanded and are no longer limited to revision surgery only. Long-term studies are needed before we can draw formal conclusions and consolidate these promising results.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53028054,"openaccessinfo":{"externalids":{"MAG":"2898508762","ACL":null,"DOI":"10.1080\/17434440.2018.1538781","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The UK's reliance on landfill sites for waste disposal has been addressed in recent years with the Landfill Directive and Landfill Tax. This has encouraged Local Authorities to seek alternative methods of treating household waste, introducing and expanding kerbside collections of recyclates and organic waste. This paper assesses current household waste management practices and challenges in the UK. Drivers and instruments for change and various approaches to kerbside waste collections are discussed. The current household waste management challenges in the UK are identified, including the division of responsibility for household waste management between various Local Authorities and Government Departments and the methods available to tackle these issues. The research revealed adopting an integrated management system for household waste to comply with legislation and behavioural attitudes towards recycling and waste reduction activities are obstacles facing Local Authorities. Conversely, segregation of household waste by material is increasing, with separate kerbside collections for recyclates, organic waste and bulky waste collections, some of which is selected for reuse. The challenge now is to improve the yield of recyclates, reach people that do not segregate their waste for recycling and increase the quantity of material from participating householders with imaginative ways for reuse and recycling.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":55276095,"openaccessinfo":{"externalids":{"MAG":"2246635755","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA\n\nBackground: Src family kinases are often over-expressed and highly active in solid tumors, including prostate cancer. This phenotype is associated with a poor prognosis partly because Src is a key factor in important signaling pathways involved in cell proliferation, angiogenesis, and initiation of metastasis. As a result, several promising small molecule targeting agents have been developed to prevent phosphorylation of key tyrosine residues that produce Src activation. However, these agents are not without side effects. The purpose of this study was to determine if adding a cytostatic soy isoflavone extract (ISF) to the treatment would produce optimal results at lower doses of the Src inhibitor. The ISF used in these studies has been shown to inhibit tumor growth in mice carrying human prostate cancer cell xenografts without causing toxicity to the host.\n\nMethods: Aggressive PC-3ML cells (a gift from A. Fatatis, Drexel University), and weakly tumorigenic LNCaP cells were treated for 24 hr with various concentrations of Src inhibitors (dasatinib, saracatinib), ISF (200 ug\/ml, NovaSoy), or a combination. To evaluate effects on the metastatic potential of the cells, functional assays of cell growth and motility were performed, including those that assess clonogenic cell survival, cell cycle progression, and transwell migration and invasion activity.\n\nResults: Src inhibitors and ISF alone produced very little reduction in cell viability, but significant cytostatic effects, as determined by a reduction in clonogenicity, the number of cells able to form 50-cell colonies. This was likely due, in part, to changes in cell cycle progression. Both dasatinib and saracatinib caused an accumulation of cells in the G1 phase. As expected, ISF treatment resulted in higher numbers of cells in the G2\/M phase. When the treatments were combined, cells exposed to dasatinib were observed to accumulate in both phases, with a significant decrease in S-phase cells. The results were not significant for saracatinib-treated cells. Exposure to either a Src inhibitor or ISF significantly reduced the migration of cells in a transwell chamber and their ability to invade through a Matrigel-coated 8 micron-pore membrane towards a chemoattractant (media containing 10% FBS). Dasatinib produced much greater effects, and at lower concentrations, than saracatinib. When combined with ISF, the effects were enhanced, particularly with dasatinib.\n\nConclusions: In vitro studies suggested that combining a Src inhibitor and ISF resulted in greater inhibition of metastatic potential than either alone. This may indicate that including ISF in treatment regimens may allow a lower dose of the targeting agent to be used to achieve optimal response and also decrease toxicity.\n\nCitation Format: Lori P. Rice, Christine Pampo, Sharon Lepler, Dietmar W. Siemann. Effects of Src inhibitors and soy isoflavones on human prostate cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 777. doi:10.1158\/1538-7445.AM2015-777","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":79190116,"openaccessinfo":{"externalids":{"MAG":"2564626475","ACL":null,"DOI":"10.1158\/1538-7445.AM2015-777","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The persistent pain cycle diagram is a common feature of pain management literature. but how is it designed and is it fulfilling its potential in terms of providing information to motivate behavioral change? This article examines on-line persistent pain diagrams and critically discusses their purpose and design approach. By using broad information design theories by Karabeg and particular approaches to dialogic visual communications in business, this article argues the need for motivational as well as cognitive diagrams. It also outlines the design of a new persistent pain cycle that is currently being used with chronic pain patients in NHS Bradford, UK. This new cycle adopts and then visually extends an established verbal metaphor within acceptance and commitment therapy (ACT) in an attempt to increase the motivational aspects of the vicious circle diagram format.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33587754,"openaccessinfo":{"externalids":{"MAG":"2000807499","ACL":null,"DOI":"10.1080\/10410236.2012.715537","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Context. Turbulent fluxes of angular momentum and enthalpy or heat due to rotationally affected convection play a key role in determining differential rotation of stars. Their dependence on latitude and depth has been determined in the past from convection simulations in Cartesian or spherical simulations. Here we perform a systematic comparison between the two geometries as a function of the rotation rate. Aims. Here we want to extend the earlier studies by using spherical wedges to obtain turbulent angular momentum and heat transport as functions of the rotation rate from stratified convection. We compare results from spherical and Cartesian models in the same parameter regime in order to study whether restricted geometry introduces artefacts into the results. In particular, we want to clarify whether the sharp equatorial profile of the horizontal Reynolds stress found in earlier Cartesian models is also reproduced in spherical geometry. Methods. We employ direct numerical simulations of turbulent convection in spherical and Cartesian geometries. In order to alleviate the computational cost in the spherical runs, and to reach as high spatial resolution as possible, we model only parts of the latitude and longitude. The rotational influence, measured by the Coriolis number or inverse Rossby number, is varied from zero to roughly seven, which is the regime that is likely to be realised in the solar convection zone. Cartesian simulations are performed in overlapping parameter regimes. Results. For slow rotation we find that the radial and latitudinal turbulent angular momentum fluxes are directed inward and equatorward, respectively. In the rapid rotation regime the radial flux changes sign in accordance with earlier numerical results, but in contradiction with theory. The latitudinal flux remains mostly equatorward and develops a maximum close to the equator. In Cartesian simulations this peak can be explained by the strong banana cells. Their effect in the spherical case does not appear to be as large. The latitudinal heat flux is mostly equatorward for slow rotation but changes sign for rapid rotation. Longitudinal heat flux is always in the retrograde direction. The rotation profiles vary from anti-solar (slow equator) for slow and intermediate rotation to solar-like (fast equator) for rapid rotation. The solar-like profiles are dominated by the Taylor-Proudman balance.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":14138515,"openaccessinfo":{"externalids":{"MAG":"2041489124","ACL":null,"DOI":"10.1051\/0004-6361\/201015884","PubMedCentral":null,"ArXiv":"1010.1250"},"license":null,"url":"https:\/\/www.aanda.org\/articles\/aa\/pdf\/2011\/07\/aa15884-10.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The core curriculum is essential for the flourishing of a Catholic college or university, as it is one of the most visible ways in which a distinctive vision becomes incarnate. Catholic colleges tend to offer some mission-centered majors and minors, but the core is what is present for all students. The core is not only significant, but also complex, for the process of developing, revising, implementing, and overseeing the core brings together what is not always in harmony: the college's vision, administrative structures, departmental interests and priorities, faculty capacities, and student needs and preferences. Most colleges revisit their core on a regular basis. What principles and strategies might guide those discussions? What might the vision look like, and what might be realizable? This paper examines those questions and, above all, explores the meta-issues of reforming and fostering a curriculum, beginning with the question of leadership and ending with practical questions of faculty development. I give less attention to the question of which courses Catholic liberal arts colleges should require, though I do explore options, including a modifi cation of the widespread tendency to delegate all mission courses to philosophy and theology.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":143191664,"openaccessinfo":{"externalids":{"MAG":"1962355287","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The high optical density of the conventional positive resist in the deep UV region (190 nm to 300 nm) prevents its use in the fabrication of high contrast patterns. The photobleachable deep UV resist composed of a 1,3\u2010dicarbonyl\u20102\u2010diazo compound as the alkaline dissolution inhibitor and an alkaline\u2010soluble styrene polymer as the resin matrix, which we developed, is one promising approach to resolve these problems. Using this resist, high contrast 0.5 \u03bcm patterns were obtained with a KrF excimer laser stepper. In this paper, we have applied photoacid generators to such photobleachable resists. The photoacid generator used was triphenylsulfonium hexafluoroarsenate, and it greatly enhanced the sensitivity and contrast of the resist. The decomposition of diazo compound in the resist was significantly enhanced (and the dissolution characteristics improved) in the presence of the onium salt. This novel positive resist utilizing chemical amplification more than meets the requirements for KrF excimer laser lithog...","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":96161563,"openaccessinfo":{"externalids":{"MAG":"1996992718","ACL":null,"DOI":"10.1116\/1.584540","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An novel resonant-cavity Si photodiode was fabricated using a selective epitaxial growth process. The photodiode shows a bandwidth over 5 GHz, and a quantum efficiency over 65% at 700 nm. Compared to the previously reported Si resonant-cavity Si photodetectors, this photodiode process is more compatible with Si integrated circuit technology.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":36569206,"openaccessinfo":{"externalids":{"MAG":"2171345144","ACL":null,"DOI":"10.1109\/68.651135","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The premise behind all evolutionary methods is ldquosurvival of the fittest,rdquo and consequently, individuals require a quantitative fitness measure. This paper proposes a novel strategy for evaluating individual's relative strengths and weaknesses, as well as representing these in the form of a binary string fitness characterization (BSFC); in addition, as customary, an overall fitness value is assigned to each individual. Utilizing the BSFC, we demonstrate both novel population evaluation measures and a pairwise mating strategy, comparative partner selection (CPS), with the aim of evolving a population that promotes effective solutions by reducing population-wide weaknesses. This strategy is tested with six standard genetic programming benchmarking problems.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":5480220,"openaccessinfo":{"externalids":{"MAG":"2162492057","ACL":null,"DOI":"10.1109\/TEVC.2008.917201","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recent studies have suggested the existence of a patient population with esophageal eosinophilia that responds to proton pump inhibitor therapy. These patients are being referred to as having proton pump inhibitor responsive esophageal eosinophilia (PPI-REE), which is currently classified as a distinct and separate disease entity from both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). The therapeutic effect of proton pump inhibitor (PPI) on PPI-REE is thought to act directly at the level of the esophageal mucosa with an anti-inflammatory capacity, and completely independent of gastric acid suppression. The purpose of this manuscript is to review the mechanistic data of the proposed immune modulation\/anti-inflammatory role of the PPI at the esophageal mucosa, and the existence of PPI-REE as a distinct disease entity from GERD and EoE.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2333775,"openaccessinfo":{"externalids":{"MAG":"1994741304","ACL":null,"DOI":"10.3748\/wjg.v20.i30.10419","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.3748\/wjg.v20.i30.10419","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract Children with parents with mental health problems have an increased risk of adverse developmental outcomes. Nonetheless, services for these children are still scarce in Switzerland. Therefore, an innovative program was developed, implemented, and evaluated in close practitioner-researcher cooperation. The program aims to support these children by providing lay supporters as so-called \"godparents\" to them. The program evaluation shows that the continuity of contacts between children and godparents builds the ground for a relationship that fosters the children's development and relieves their parents. A carefully undertaken process of matching families with godparents appears to be crucial for a lasting godparenthood. However, a main challenge is the acquisition of godparents, who engage on a voluntary basis in the program.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":150231054,"openaccessinfo":{"externalids":{"MAG":"2902334521","ACL":null,"DOI":"10.1080\/0145935X.2018.1526071","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The antioxidant and neuroprotective activities of essential oil (EO),isolated from Chinese herb pairs of Angelica sinensis and Sophora flavescens were studied in this paper. EO significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. EO treatment decreased the levels of tumor necrosis factor alpha, interleukin 1 beta and oxidative stress. Our results had showed that EO was a potent neuroprotective medicine.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":55579636,"openaccessinfo":{"externalids":{"MAG":"2160256167","ACL":null,"DOI":"10.7324\/JAPS.2012.2505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The in vivo effect of bacterial lipopolysaccharides (LPS) on mouse spleen cell subpopulations was investigated. Intravenous administration of LPS resulted in marked enlargement of the spleen, accompanied by increased cellular proliferation and enhanced nucleated cell recoveries. At least two morphologically distinct cell types appeared to be targets for LPS. Polymorphonuclear leukocytes accumulated rapidly with a relatively minor degree of cell division. In contrast, a substantial proportion of splenic lymphocytes transformed into large lymphocytes and blast cells which actively incorporated [3H]thymidine. Proliferating cells were identified as bone marrow-derived (B) lymphocytes by their ability to form C3-dependent rosettes and to synthesize immunoglobulin. These cellular responses were not antigenically induced, since LPS derived from mutants lacking the polysaccharide moiety gave similar results. Thus, splenic B lymphocytes appear to interact and respond to LPS in vivo in the same manner as observed in vitro. These data suggest that the capacity of LPS to directly activate B lymphocytes, initiate cellular proliferation, and induce immunoglobulin production by bone marrow-derived cells in vivo may contribute to its adjuvant activity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20848716,"openaccessinfo":{"externalids":{"MAG":"2150475585","ACL":null,"DOI":"10.1128\/iai.19.1.71-78.1978","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iai.asm.org\/content\/iai\/19\/1\/71.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Why do some countries walk on the right and others on the left? People have a dominant hand which leads to a natural tendency to favor one side of the road or another depending on the means of transportation being used. The primary objective of this study was to investigate the stereotype of Korean regarding preferred walking direction in encountering various facilities and provide the appropriate information to traffic policy makers. Six hundred Korean male and female subjects aging from 12 to 83 were selected to investigate the various statistics about their preferred walking direction and their employment characteristics on walking diverse facilities. The walking directions of eleven different facilities were asked along with other relative subjects' characteristics(e.g., age, gender, hand and foot dominance) to determine the relationship among these obtained data. The descriptive statistics showed that 73.7% and 26.3% were preferred walking right and left direction respectively. Moreover, various statistical analysis revealed that general tendency of walking direction was varied by hand and foot dominances. There were strong tendency that right-handed people prefer walking right side of the road and vise versa, hence this should be considered in setting up traffic policies. As a concluding remark, it is better to design traffic policies and regulations in the way that peoples' preference and expectation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":130725984,"openaccessinfo":{"externalids":{"MAG":"2210578155","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Our research goal is to construct an environment that mechanically supports human intellectual activities through software development with reuse. We propose a model of software development with systematic reuse in which the existing program can be altered to meet the given specification change using the program derivation process from the specification. We consider what kinds of knowledge must be acquired when a specification is changed and how they have to be integrated so well as to implement our method on a computer system. In particular, we focus on the following points in terms of program synthesis. First, a wide spectrum language, Extended IML, defines a framework in which specifications, program and the elaborate derivation process can be expressed formally on a computer system. This forms a basic unit of reusable knowledge for specification change. Second, a reuse process is formulated in which a new requirement changes the efficient specification and its program is altered to meet this requirement correctly. Third, we consider some conditions and a mechanism by which the knowledge can be integrated so as to obtain an objective program automatically, implying that we will yet profit from reusing the knowledge.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":14776934,"openaccessinfo":{"externalids":{"MAG":"2122022880","ACL":null,"DOI":"10.1109\/APSEC.1995.496985","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present research work was conducted to evaluate the effect of replacement of sunflower meal with Moringa oleifera leaves meal or its combination with phytase enzyme on blood profile of broiler. Two hundred day-old Ross broiler chicks from a commercial hatchery were purchased & after initial weight; birds were arbitrarily separated in groups, i.e. In group A (control), 0% MOLM and Phytase enzyme g\/kg, group B, 2.5% MOLM, group C, 2.5% MOLM with combination of 0.075 g\/kg Phytase enzyme and in group D, 0.075 g\/kg Phytase enzyme were provided in broiler feed. Parameters which selected in present research work as,Result showed that, the live body weight in group C diet recorded significantly (P<0.05) the maximum body weight gain, feed intake in group A feed intake was higher than group B, C and D,The water intake of group A (control) was although in different treatments groups B, C and group D. Maximum water intake was recorded in group A (control) and minimum in treated group C (L\/chick), the FCR percentage showed non-significantly different from groups A, B from one another while significant from group C and D in feed conversion ratio (FCR) among the groups,The dressing percentage in group C was higher than group B, D and group A (control),Mortality percentage of broiler chicks in different treatment groups was minimum supplement with Moringa oleiferia leaves with combination of Phytase enzyme, The highest weight of liver, gizzard, heart, intestine were noted in treated group C comparatively, highest spleen weight was in group B and in group A (control) the minimum weight of spleen was noted and theaverage blood profile of broiler chicks in different groups, the white blood cells was significantly higher in group D followed by group A, group B and C. Red blood cells was significantly (P<0.05) better in group C. Haemoglobin was significantly differences in different groups of trial. A significant (P<0.05) difference in Packed cells volume in group A followed by group B, C and D. Total protein in group A was minimum followed by group B, C and D, respectively.From the present study, it was concluded that supplementation with 2.5% MOLM with the combination of 0.075 g\/kg Phytase enzyme have better effect on growth performance and blood profile of broiler.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":244962372,"openaccessinfo":{"externalids":{"MAG":"3176880001","ACL":null,"DOI":"10.36648\/2572-5459.21.6.86","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The history of impact testing of plastics is reviewed and the current theories of impact resistance are discussed. The effect of velocity on the energy absorbed by polymethyl methacrylate at various temperatures has been studied with the aid of two new testing machines. The results are interpreted in terms of the classical theories of mechanics of materials and the current theories of the rheology of high polymers. It is concluded that there are two distinct critical velocities of straining in this material\u2014the lower one corresponding to the relaxation of the bonds restraining chain-chain slipping and the higher one corresponding to the relaxation of the secondary bonds involved in chain uncoiling. Both of these relaxations are temperature dependent\u2014the lower one to a slight extent and the upper one to a marked extent. Above the two critical velocities the response of the material is purely elastic. A method of calculating the energy to break at rates of straining above the second critical velocity from the slow-rate stress-strain curves is demonstrated.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":251183452,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/1.4015842","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Almost all creolists see creole formation as a case of (failed) second language acquisition. I argue that there are good reasons to distinguish between second language acquisition and pidginisation\/creolisation, and that little is gained by equating the two. While learners have an extant language as their target, pidginisers typically aim to communicate (in any which way) rather than to acquire a specific language. In this sense, pidginisation represents, if not \"conscious language change\", at least \"conscious language creation\".","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":202359693,"openaccessinfo":{"externalids":{"MAG":"2967243183","ACL":null,"DOI":"10.1163\/22105832-00902005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effect of acute 1,1,1-trichloroethane (1,1,1-TCE) inhalation on left ventricular contractility and influence on heart rate were investigated in anesthetized dogs. In the acute inhalation experiment, a decrease in the maximum left ventricular dp\/dt (peak dp\/dt) was observed following inhalation of higher 1,1,1-TCE contentrations. The threshold concentration of 1,1,1-TCE that decreased peak dp\/dt was approximately 0.2% in inspired air. A dose-response relationship was observed between the decrease in peak dp\/dt and 1,1,1-TCE concentration. Heart rate recorded simultaneously increased with relatively low concentrations and decreased with higher concentrations. Increase or decrease in peak dp\/dt was observed to be dependent on changes in heart rate induced by right atrial pacing. Thus, the degree of the decrease in peak dp\/dt during pacing experiments was compared with those of nonpacing experiments. At low concentrations, peak dp\/dt during pacing decreased more than in nonpacing experiments. With higher concentrations, the decreases in peak dp\/dt during pacing was slightly less than in the nonpacing experiments. Heart rate may be important in regulating peak dp\/dt for relatively low 1,1,1-TCE concentrations. However, the effect of heart rate on peak dp\/dt is slight at higher concentrations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22075553,"openaccessinfo":{"externalids":{"MAG":"2017947771","ACL":null,"DOI":"10.1080\/00039896.1988.9935863","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A detailed analysis of the antenatal cardiotocographs (CTGs) in 57 patients with suspected fetal growth retardation is presented. Four traces were normal and 53 were 'non\u2010reactive. 'Non\u2010reactive' traces can be sub\u2010divided into three categories, which, in order of severity are, 'suspect', 'flat' and 'ominous'. When compared with the 'suspect' group, perinatal mortality was significantly increased and the Apgar scores at one and five minutes significantly decreased in the 'flat' and 'ominous' groups. The presence of fetal distress in labour was significantly higher in the 'flat' group as compared with the 'suspect' group. Intrauterine deaths occurred only in the 'ominous' group. With experience, ten patients later in the series with 'ominous' patterns were delivered within 24 hours of the detection of such and nine infants survived. At follow\u2010up between 6 and 34 months after birth, psychomotor development was normal in 47 of the 49 surviving infants.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206906518,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/1471-0528.13209","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/1471-0528.13209","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT In this work we use the mode decomposition technique employing chirplet transform, which is able to separate the individual modes from dispersive and multimodal waveform measured with the magnetostrictive sensor. The mode decomposition technique is also used to estimate the time-fre-quency centers and individual energies of the reflection, which would be used to locate and charac-terize axial defects. The arrival times of the separated modes are calculated and the axial defect lengths can be evaluated by using the estimated arrival time. Results from an experiment on a car-bon steel pipe are presented and it is shown that the accurate and quantitative defect characterization could become enabled using the proposed technique. * 1. \uc11c \ub860 \uc720\ub3c4\ud30c(guided waves)\ub294 \ud604\uc7ac \ube44\ud30c\uad34\uac80\uc0ac\uc758 \uc911\uc694\ud55c \uc218\ub2e8\uc73c\ub85c \uc790\ub9ac \uc7a1\uac8c \ub418\uc5c8\uc73c\uba70, \ub9ce\uc740 \uae30\uc220\uc801 \uc9c4\ubcf4\uc5d0 \ud798\uc785\uc5b4 \uc11d\uc720\ud654\ud559, \ucca0\uac15, \ubc1c\uc804\uc124\ube44\uc5d0 \uc4f0\uc774\ub294 \ubc30\uad00\uc758 \uac80\uc0ac\uc5d0 \uc790\uc8fc \uc774\uc6a9\ub418\uace0 \uc788\ub2e4 (1\u223c4) . \uadf8\ub7ec\ub098 \uacb0\ud568\uc744 \ubc1c\uacac\ud574\ub3c4 \uadf8 \ud06c\uae30\ub97c \uc815\ub7c9\uc801\uc73c\ub85c \ud3c9\uac00\ud558\uac70\ub098 \uc774\ub85c \uc778\ud55c \ubc30\uad00\uc758 \uc704\ud5d8\uc131\uc744 \ud30c\uc545\ud558\ub294 \uac83\uc740 \uc544\uc9c1\ub3c4 \ub9ce\uc740 \uc5f0\uad6c\uac00 \ud544\uc694\ud55c \ubd84\uc57c\ub77c\uace0 \ud560 \uc218 \uc788\ub294\ub370, \uadf8 \uc774\uc720\ub294 \uacb0\ud568\uc5d0\uc11c \ubc18\uc0ac\ub41c \uc2e0\ud638\ub294 \uc5ec\ub7ec \uc2e0\ud638\ub4e4\uc774 \ud63c\uc7ac\ub418\uc5b4 \uc874\uc7ac\ud558\ub294 \ub9e4\uc6b0 \ubcf5\uc7a1\ud55c \uc591\uc0c1\uc744 \uac16\uae30 \ub54c\ubb38\uc774\ub2e4","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":112447818,"openaccessinfo":{"externalids":{"MAG":"2338296143","ACL":null,"DOI":"10.5050\/KSNVE.2015.25.6.399","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The novel tells the story of a middle-class UNESCO engineer called Walter Faber, who believes in rational, calculated world. Strange events undermine his security - an emergency landing in a Mexican desert against all odds, his friend Joachim hangs himself in the Mexican jungle, and he falls in love with a woman who dies of a concussion, he has an incestuous affair. Finally Faber becomes ill with stomach cancer, but it is too late for him to change his life.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":161736270,"openaccessinfo":{"externalids":{"MAG":"1516971033","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SUMMARY Between weeks 3 and 18 of lactation, 141 British Friesians all received concentrate (metabolizable energy (ME) 12\u00b79 MJ\/kg dry matter (DM), 202 g crude protein (CP)\/kg DM) at 8\u00b70 kg fresh weight\/day. In addition, cows received ad libitum either grass silage (ME 11\u00b77 MJ\/kg toluene DM; 219 gCP\/kg DM) or a mixture containing grass silage and 15, 25 or 40% (DM basis) of winter barley straw (cv. Igri) either untreated (UTS) or treated (TS) with 4% NaOH. Forage treatments were imposed at either week 3 or week 9 of lactation. The mean forage DM intake of cows receiving grass silage only was 8\u00b760 kg\/day. When 15, 25 and 40% UTS was introduced into the rations at week 3 or 9 of lactation, forage DM intakes were 884, 8\u00b743, 7\u00b762 and 8\u00b763, 8\u00b783, 819 kg\/day, respectively; the corresponding values for TS were 8\u00b788, 855, 8\u00b799 and 8\u00b797, 8\u00b798, 9\u00b735 kg7sol;day. The milk yield of cows receiving grass silage only was 22\u00b71 kg\/day. When 15, 25 and 40% UTS was introduced into the rations at week 3 or 9 of lactation, milk yields were 21\u00b71 kg\/3, 20\u00b71 kg\/1, 20\u00b71 kg\/5 and 20\u00b71 kg\/1, 21\u00b74, 20\u00b75 kg\/day, respectively; the corresponding values for TS were 21\u00b78, 22\u00b71, 21\u00b73 and 22\u00b75, 21\u00b74, 22\u00b76 kg\/day. When averaged across the three inclusion rates, TS significantly increased forage intake (P < 0\u00b705) and milk yield (P < 0\u00b701) compared with UTS. Intermediate values were recorded for the diet with grass silage alone. The inclusion of TS in the ration did not affect milk yield compared with grass silage alone. No major changes in milk composition were recorded by the inclusion of either TS or UTS. However, the yields of milk fat, protein and lactose for the TS treatments were higher than for UTS and were significant for protein (P < 0\u00b701) and lactose (P < 0\u00b7001). Cows with UTS in their ration tended to have lower live weight gains than either the control group or treatments with TS. When compared with grass silage only, the inclusion of TS or UTS decreased digestibility coefficients and ME contents, determined in vivo using wether sheep fed at maintenance. However, the treatment of straw with NaOH (4%) increased its digestibility coefficients of dry matter from 0\u00b7-393 to 0\u00b7668, of organic matter from 0\u00b7445 to 0\u00b7686, of acid detergent fibre from 0\u00b7442 to 0\u00b7713, gross energy from 0\u00b7438 to 0\u00b7640 and ME content from 7\u00b70 to 9\u00b74 MJ\/kg DM.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":84513749,"openaccessinfo":{"externalids":{"MAG":"2031649273","ACL":null,"DOI":"10.1017\/S0021859600075845","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper studies and derives new results for the interference channel with a relay (ICR). Three inner bounds for the discrete memoryless ICR are proposed, based on three coding strategies that employ layered code at the relay. The first scheme is inspired by layered noisy network coding, proposed by Lim et al. for the two-way relay channel, the second and the third schemes rely on simpler encoding and decoding processes, dubbed layered quantize-forward. Performance of the proposed schemes is investigated for two classes of channels with Gaussian noise: the interference channel with in-band relay reception\/out-of-band relay transmission and the interference with in-band relay reception\/in-band relay transmission. For the former class of channels, it is shown that the first proposed scheme achieves the same inner bound as the generalized hash-forward scheme with incremental binning. In addition, the inner bound is within 0.5 bit of the capacity region under certain conditions on the channel parameters. For the latter class of channels, new upper bounds on sum-rate are established by extending known upper bounds for symmetric channels. The first inner bound is shown to be within 0.5 bit of the capacity region if the relay's power exceeds a certain threshold, which depends on channel parameters. Numerical examples show that the proposed schemes can achieve significantly higher sum-rates when compared with other compress-forward schemes. Analysis also reveals a tradeoff between achievable rates, coding delay, and complexity of the proposed schemes. Results in this paper provide a better understanding of coding for the ICR, in particular, they show that layered coding is a beneficial element in multiuser networks with relays.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":17765769,"openaccessinfo":{"externalids":{"MAG":"1982096930","ACL":null,"DOI":"10.1109\/TIT.2014.2345064","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Numerous finite element methods have been widely used to predict the response of normal\/high strength concrete columns confined with Fiber Reinforced Polymer (FRP) under different loading conditions. In this regard, simulating the response of FRP-confined reactive powder concrete (RPC) columns has been less emphasized. The present study aimed to propose a finite element model based on fiber finite element methodology in order to predict the behavior of FRP confined RPC columns under axial compressive load with different eccentricities. The columns were modeled with a nonlinear beam-column element with two nodes with distributed plasticity. In addition, the proposed finite element model in the present study indicated its simplicity, low computational efforts, and flexibility by adopting a perfect bond between RPC and FRP. Further, the obtained results from the finite element analysis were compared to those from available tested specimens. Based on the comparisons, the proposed model can provide highly satisfactory predictions. Finally, the proposed model can be useful for efficient applications in practical engineering projects.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":237857745,"openaccessinfo":{"externalids":{"MAG":"3175856457","ACL":null,"DOI":"10.15282\/jmes.15.2.2021.17.0642","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.15282\/jmes.15.2.2021.17.0642","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper presents and compares two model-based approaches to ensure the dependability of a rail system in the context of ERTMS (European Rail Traffic Management System). V&V activities against safety properties are carried out by simulating train operations on State machine models of railway infrastructures. This paper presents this approach by means of a comparative study between two tools which analyze the models with various verification strategies. The tools used are Matlab Simulink environment and the DIVERSITY symbolic execution tool from CEA LIST.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":12331781,"openaccessinfo":{"externalids":{"MAG":"2536912740","ACL":null,"DOI":"10.1109\/IESM.2015.7380134","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Shape memory hydrogels have been paid plenty of attention as a kind of intelligent soft material. However, complicated preparation, slow and uncontrollable shape change have hindered their applications in smart actuators. In this work, a temperature responsive strong hydrogel was prepared by a facial soaking method without any chemical reactions, i.e., soaking gelatin hydrogel in aqueous tannic acid solution. The hydrogel was constructed by hydrogen bonding between gelatin and tannic acid besides the triple helix of gelatin without any chemical crosslinkers. The hydrogel showed ultrafast shape memory and body-temperature response. The hydrogel can be fixed in temporary shape in only 1 s at 25 \u00b0C and recover to the original shape in also 1 s at 37 \u00b0C, superior to the reported shape memory hydrogels. Furthermore, the hydrogel shape change can be programmed by fixing temperature, and the designed shape is achieved stepwise by adjusting recovery temperature. In addition, the hydrogel is stable in water without further swelling. These excellent features will initiate a new prosperity of the shape memory hydrogel in biomedical technology, underwater actuators, and soft robots.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221843858,"openaccessinfo":{"externalids":{"MAG":"3087170606","ACL":null,"DOI":"10.1021\/acsami.0c13531","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article describes a study to ascertain nurses' views on the role of professional journals and whether they make full use of this resource. Nearly three-quarters of nurses claimed they read journals on a monthly basis or more frequently, and valued nursing journals as a means of keeping up-to-date professionally. Most nurses also agreed that the study of current professional literature positively influenced their clinical competence. Such attributions support the view that the reading of journals should be an accredited method of learning.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24638579,"openaccessinfo":{"externalids":{"MAG":"2406464681","ACL":null,"DOI":"10.7748\/NS.8.1.22.S30","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to develop and pilot test a fall prevention education \nintervention for older persons with a high risk of falls in a primary care setting. \nThere were three phases in this study. In the needs assessment study, the needs of \ncommunity-dwelling older persons with a high risk of falls and healthcare professionals \n(HCPs) who managed falls were explored using qualitative interviews. The study was \nconducted at University Malaya Medical Centre (UMMC), Kuala Lumpur from July \n2012 to April 2013. Semi-structured topical guides were developed to facilitate the \ninterviews. The transcribed interview data were analysed thematically using Weft QDA. \nA systematic literature review was conducted to determine the effectiveness of FPEIs. \nThe intervention was developed based on the evidence from the findings of the needs \nassessment, systematic review, theories and clinical practice guidelines. The \nMultifaceted Fall Education by Interprofessional Team (MuFE_IT) intervention consists \nof presentations by inter-professional team and a fall prevention education booklet. The \nMuFE_IT was then pilot-tested in three group sessions and revised based on the \nfeedback from the participants. The study participants' knowledge and behavioural \nchanges were evaluated using questionnaires and focus-group discussions immediately, \none-month, and three-month post-intervention. The data were analysed using SPSS and \nWeft QDA. \nIn the needs assessment study, both the HCPs and older persons highlighted the need \nfor educational materials on fall prevention. HCPs perceived their roles as the \niv \ncoordinator of care and provider of advice on fall prevention to older persons. HCPs \nwere aware that they needed to consider older persons' views, beliefs and behaviours \nwhen offering fall prevention advice. A systematic literature review of 21 RCTs found \nthat FPEIs which involved HCPs in providing fall advice, educational pamphlets, small \ngroup sessions, video and multimedia presentations were effective. In the qualitative \nevaluation of the MuFE_IT, four themes emerged: change of attitude towards fall \nprevention, actions taken related to fall prevention, barriers in MuFE_IT \nimplementation, and reasons to take action to prevent falls. The participants were more \n'careful', 'compliant' and 'motivated' to prevent falls. The participants found the \nfollowing components of the MUFE_IT intervention useful: professional advice from \nthe presentation on proper shoe wear, medication review and home interior \nmodification; information from the education booklet on fall prevention activities such \nas exercises; small discussion groups that eased interaction and allowed information to \nbe shared among the participants. However, a few participants perceived that the advice \ngiven at the MuFE_IT intervention was 'common sense' and 'not practical', as these \nparticipants were already practising fall prevention activities. In addition, there was no \nimprovement in their knowledge after attending the MuFE_IT intervention sessions. \nThis study confirms the feasibility of developing an FPEI for older persons based on \nneeds, evidence and theories using mixed research methods. The MuFE_IT warrants \nfurther study to evaluate its effectiveness in preventing falls in the Malaysian primary \ncare setting.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":151013179,"openaccessinfo":{"externalids":{"MAG":"2924638418","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"tension in later life was seen in the questionnaire and clinical examination data and also in the hospital diagnosis data and the mortality data. We suggest that our observations cannot be explained by chance or bias. The findings have implications for the aetiology and pathogenesis of circulatory disease, both in pregnancy and in later life. They also suggest that interventions that might minimise the risk of such conditions in later life should be identified and evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220111942,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmj.326.7394.849\/b","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.bmj.com\/content\/bmj\/326\/7394\/849.3.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"NAFLD is a very common asymptomatic liver condition that may progress to cirrhosis and hepatocellular \ncarcinoma, and a relation to the different components of the metabolic syndrome has \nbeen found. In this review we highlight some of the epidemiological aspects of the two disorders \nand discuss some of the possible mechanisms and questions to be answered concerning the risk \nfactors for the progression of this condition as well as the need for more studies to focus on possible \nmodalities of treatment","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":68460650,"openaccessinfo":{"externalids":{"MAG":"206838945","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The conversation with Sergey Khoruzhiy took place in March of the year during his visit to the Institute of Human Sciences in Vienna. The questions were asked at that time by the Institute's freelance staff \u2014 Kristina Stoeckl and Alexander Mikhailovsky. The conversation was conducted in English. The transcribed text of the interview with abbreviations was published in the journal Studies in East European Thought: Michailowski A., Stoeckl K. Interview with Sergey Horujy \/ \/ Studies in East European Thought. \u2014 2016. - Vol. 68, No. 2\/3. - P. 1-8. Russian translation by A.V. Mikhailovsky.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233553182,"openaccessinfo":{"externalids":{"MAG":"3143696487","ACL":null,"DOI":"10.17323\/2587-8719-2021-1-169-181","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.17323\/2587-8719-2021-1-169-181","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The high nutritive value and diverse functional properties of milk proteins are well known. In recent years, intense scientific research has been focused on the identification of factors within bovine milk that may be relevant to improving human health. The best characterized wheybased bioactive proteins include \u03b1-lactalbumin, \u03b2-lactoglobulin, immunoglobulins, lactoferrin, lactoperoxidase and growth factors. These proteins exhibit a wide range of biological activities that may influence the digestive function, metabolic responses to absorbed nutrients, growth and development of organs and disease resistance. Some whey proteins may reduce the risks of chronic human diseases reflected by the metabolic syndrome. Whey proteins are a good source of various bioactive peptides which are encrypted within the proteins and can be released during gastric digestion or food processing by enzymes or microbes. Whey proteinderived peptides have been shown to exert a wide range of bioactivities affecting the cardiovascular, immune and nervous systems. The efficacy of a few peptides has been established in animal and human studies. A number of commercial whey-based protein products with potentital health benefits are on the market and this is envisaged to increase on a global scale.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209547829,"openaccessinfo":{"externalids":{"MAG":"2521995536","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Previous descriptions of thermal emission spectroscopy have presented techniques that vary in accuracy and reproducibility. Contributions of thermal energy from the instrument and environment are major calibration factors that limit accuracy in emissivity determination. Reproducibility is related to the stability of these quantities. Sample temperature determination is also a significant factor in arriving at accurate emissivity. All of the factors which impact the measurement of emissivity using an interferometric spectrometer with an uncooled detector are isolated and examined here. An experimental apparatus is presented along with a description of a simplified measurement and calibration scheme used to arrive at quantitative emissivity of minerals. A detailed error analysis examines the effect of errors in each of the calibration parameters in isolation and as part of multiple error propagation. Sample temperature determination from radiance can create emissivity error, but 95% of published minerals have an emissivity maximum of 0.98 or higher, resulting in emissivity error of 2% or less. With worst-case systematic and random errors included, emissivity can be determined with an uncertainty of \u223c4%. In most cases it is less than 2%. Reproducibility with this technique is better than 1%.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":128466219,"openaccessinfo":{"externalids":{"MAG":"2000024155","ACL":null,"DOI":"10.1029\/97JB00593","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The United States Supreme Court's 2002\u201303 term confounded Court watchers. The same Rehnquist Court that many had seen as solidly conservative and unduly activist\u2014the Court that helped decide the 2000 presidential election and struck down thirty-one federal statutes since 1995\u2014issued a set of surprising, watershed rulings. In a term filled with important and unpredictable decisions, it upheld affirmative action, invalidated a same-sex sodomy statute, and reversed a death sentence due to ineffective assistance of counsel. With essays focused on individual Justices, Court practices, and some of last year's most important rulings, this volume explores the meaning and significance of the Court's 2002\u201303 term. Seasoned Supreme Court advocates and journalists from The New Republic , The Los Angeles Times , Newsweek, National Journal , Slate , and Legal Times grapple with questions about the Rehnquist Court's identity and the Supreme Court's role in the political life of the country.\n\nSome essays consider the role of \"swing\" Justices Sandra Day O'Connor and Anthony Kennedy within a Court that divides 5\u20134 more than any other group of Justices in the nation's history. Others examine the political reaction to and legal context of the Court's Lawrence v. Texas decision declaring a Texas law criminalizing homosexual sodomy unconstitutional. Contributors analyze the Court's rulings on affirmative action and reassess its commitment to states' rights. Considering the Court's practices, one advocate explores the use and utility of amicus curiae , or \"friend of the court\" briefs, while another reflects on indications of an increased openness by the Court to public scrutiny. Two advocates who argued cases before the Court\u2014one related to hate speech and the other to a \"three strikes and you're out\" criminal statute\u2014offer vivid accounts of their experiences. Intended for general readers, A Year at the Supreme Court is for all those who want to understand the Rehnquist Court and its momentous 2002\u201303 term.\n\nContributors\n\nErwin Chemerinsky\n\nNeal Devins\n\nDavison M. Douglas\n\nDavid J. Garrow\n\nDahlia Lithwick\n\nTony Mauro\n\nCarter Phillips\n\nRamesh Ponnuru\n\nJeffrey Rosen\n\nDavid G. Savage\n\nRodney A. Smolla\n\nStuart Taylor Jr.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153960360,"openaccessinfo":{"externalids":{"MAG":"1859221159","ACL":null,"DOI":"10.1215\/9780822385950","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We attempt to understand the baryon-dark-matter coincidence problem within the quark seesaw extension of the standard model where parity invariance is used to solve the strong CP problem. The $SU(2)_L\\times SU(2)_R\\times U(1)_{B-L}$ gauge symmetry of this model is extended by a dark $U(1)_X$ group plus inclusion of a heavy neutral vector-like fermion $\\chi_{L,R}$ charged under the dark group which plays the role of dark matter. All fermions are Dirac type in this model. Decay of heavy scalars charged under $U(1)_X$ leads to simultaneous asymmetry generation of the dark matter and baryons after sphaleron effects are included. The $U(1)_X$ group not only helps to stabilize the dark matter but also helps in the elimination of the symmetric part of the dark matter via $\\chi-\\bar{\\chi}$ annihilation. For dark matter mass near the proton mass, it explains why the baryon and dark matter abundances are of similar magnitude (the baryon-dark-matter coincidence problem). This model is testable in low threshold (sub-keV) direct dark matter search experiments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":128002321,"openaccessinfo":{"externalids":{"MAG":"2746297575","ACL":null,"DOI":"10.1103\/PhysRevD.96.055011","PubMedCentral":null,"ArXiv":"1705.01872"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ability of glucose to stimulate insulin secretion from the pancreatic islets of Langerhans is enhanced by the intestinal hormone glucagon-like peptide 1 (GLP-1), which is secreted from the gut in response to nutrient ingestion. This action, called the incretin effect, accounts for as much as half of the postprandial insulin response and is exploited therapeutically for diabetes treatment through the use of incretin mimetic drugs and inhibitors of dipeptidyl peptidase 4, which degrades GLP-1. Despite a prominent role for incretin mimetics in diabetes treatment, several key questions remain about GLP-1-induced insulin secretion. Most studies have examined the effects of GLP-1 at concentrations several orders of magnitude higher than those found in vivo; therefore, one might question the physiological (and perhaps even pharmacological) relevance of pathways identified in these studies and whether other important mechanisms might have been obscured. In this issue of the JCI, Shigeto and colleagues demonstrate that physiological GLP-1 does indeed amplify the insulin secretory response. Intriguingly, while much of this response is PKA dependent, as might be expected, the use of picomolar GLP-1 reveals a new and important mechanism that contributes to GLP-1-induced insulin secretion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28591174,"openaccessinfo":{"externalids":{"MAG":"2173898107","ACL":null,"DOI":"10.1172\/JCI85004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is well known that high frequency fields can be used to create different structures in a plasma medium. Now this application of electromagnetic waves can be considered as one of the directions in plasma physics. Structures with specific properties are created in certain places of a plasma medium furnished to achieve defined effects, that are important for some applications. Intricate processes are used in a CERA-A (Cyclotron Electron Resonance Applications-Accelerator) device, which was constructed for plasma flow acceleration. To create a wider accelerated ion flow a CERA-V (V-variable ion energy) device was made, where in-phase electron plasma oscillations in a narrow layer of a plasma column were used.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119942459,"openaccessinfo":{"externalids":{"MAG":"1899975931","ACL":null,"DOI":"10.1109\/UHF.1999.787980","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present review is focused on the identification, composition and function of endogenous and exogenous pulmonary surfactants. This approach includes the physico-chemical and biochemical analysis of the action of pulmonary surfactant, especially in the alveolar site. The therapeutic employment of pulmonary surfactants has been studied as one of the most important therapies for the treatment of respiratory diseases that affect several patients, especially in the perinatal phase. Furthermore, the development of new artificial pulmonary surfactant substitutes is described. This effort is based on analogues of native surfactant proteins and consists in a relevant challenge for future research. Indeed, this pharmacological advancement has been developed in order to improve the treatments used in the present days regarding various pathological states of the respiratory system. In this way, the work also reviews the advancements and limitations of the therapeutic procedures based on pulmonary surfactants, since this methodology is extremely auspicious to improve the expectative and quality of life of patients with respiratory diseases. Various cases are related and the state of art of this important topic is discussed in details.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1,"unknown":2}},"corpusid":80414961,"openaccessinfo":{"externalids":{"MAG":"2797794679","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The whooping crane is one of the most critically endangered species in North America. The species underwent a severe genetic bottleneck with only 16 individuals remaining in the wild as of 1942. Captive breeding began in 1966 and continues to produce chicks for release in order to establish new wild populations. However, captive birds experience poor reproduction with approximately 40% of eggs being infertile. Males have been known to reach sexual maturity at 5 years of age and continue to reproduce almost as long as the duration of their adult life (i.e. 40 years). Understanding factors affecting seminal quality may assist in identifying and correcting causes of suboptimal reproduction. Our objectives were to determine the influence of age and reproductive seasonality on seminal quality. We hypothesised that seminal quality variations among whooping cranes and ejaculates within a given individual over time were due to bird age and stage of breeding season. In 2010, twenty-nine whooping cranes of 5 age groups housed at Patuxent Wildlife Research Center (Laurel, MD, USA) were studied: \u22645 years (n\u2009=\u20093); 6\u201310 years (n\u2009=\u20097); 11\u201315 years (n\u2009=\u20097); 16\u201320 years (n\u2009=\u20094); >20 years old (n\u2009=\u20098). Semen was collected using a manual manipulation technique at 3 stages of the breeding season: early (March, n\u2009=\u200929) mid (April, n\u2009=\u200924), and late (May, n\u2009=\u200914). Samples were evaluated for seminal volume and sperm concentration, motility, and morphology, with data evaluated by analysis of variance. Bird age had no influence on seminal quality, whereas stage of breeding season affected seminal volume and the proportion of sperm with normal morphology (95% confidence interval). Specifically, samples collected during Mid breeding season had the highest volume (mean\u2009\u00b1\u2009SEM; early: 42.0\u2009\u00b1\u20098.0\u2009\u03bcL; mid: 66.0\u2009\u00b1\u200915.2\u2009\u03bcL; late: 39.7\u2009\u00b1\u200917.8\u2009\u03bcL), but lowest proportions of structurally normal sperm (early: 78.4\u2009\u00b1\u20093.7%: mid: 61.5\u2009\u00b1\u20093.2%; late: 69.7\u2009\u00b1\u20093.4%). There was a significant difference (P\u2009=\u20090.06) in sperm concentration among stages of the breeding season (early: 66.3\u2009\u00b1\u200918.8\u2009\u00d7\u2009106 sperm\u2009mL\u20131; mid: 179.2\u2009\u00b1\u200946.2\u2009\u00d7\u2009106 sperm\u2009mL\u20131; late: 91.4\u2009\u00b1\u200947.8\u2009\u00d7\u2009106 sperm\u2009mL\u20131). Sperm motility was unaffected by season (early: 36.4\u2009\u00b1\u20093.5%; mid: 45.9\u2009\u00b1\u20094.1%; late: 48.0\u2009\u00b1\u20094.9%). In summary, there is a peak in seminal quality that corresponds with higher volume and more sperm during the mid stage of the season, although with higher instances of structural abnormalities. Despite the small founder base for this species, males in this population produce sperm with no variation in seminal quality across a wide variation in age.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":85202558,"openaccessinfo":{"externalids":{"MAG":"2057270155","ACL":null,"DOI":"10.1071\/RDV23N1AB231","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors present a case of periappendicular abscess in a 5-day-old full-term neonate. Prompt diagnosis enabled us to deliver conservative treatment followed by interval laparoscopic appendectomy, instead of a risky urgent laparotomy. This is the first description of an advanced imaging-guided drainage procedure, followed by minimal invasive surgery, for the treatment of periappendicular abscess at such a young age.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26410600,"openaccessinfo":{"externalids":{"MAG":"1989217414","ACL":null,"DOI":"10.1053\/JPSU.2003.50065","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Skeletal muscle ischemia reperfusion injuries can occur with diseases, trauma and during surgical procedures. Ischemia reperfusion injury is characterized by the production of oxygen free radicals leading to disturbances in vasomotility and microvascular permeability. The objective was to evaluate effects of N-acetylcysteine as a scavenger of radical oxygen species on the serum enzyme changes secondary to muscle ischemia reperfusion. Twenty wistar male rats were divided randomly into two experimental groups: group ischemia-reperfusion (group I) and group ischemia-reperfusion + N-acetylcysteine (group II). After ketamine (50 mgkg-1) and xylazine (10 mgkg-1) anesthesia, femoral artery was exposed and undergone 2h of ischemia, 24h of reperfusion. Rats that were treated with N-acetylcysteine given intravenously at a dose of 150 mgkg-1, immediately before reperfusion. After 24h of reperfusion, the blood samples were collected and submitted for evaluation of serum aspirate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase (CPK), lactate dehrdrogenase (LDH) values to identify the ischemic damage occurring in the skeletal muscle tissue. Enzymatic parameters (CPK, AST, ALT and LDH) measured for demonstrating ischemia induced muscle injuries were lower in the group receiving Nacetylcysteine. In this study, N-acetylcysteine as an antioxidant substance was demonstrated to have protective effects on acute ischemia and reperfusion injury of the skeletal muscle in lower extremities.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":40714286,"openaccessinfo":{"externalids":{"MAG":"2608407955","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi and affects about 15 million people in the Americas. In the Brazilian Amazon Basin, the disease is enzootic, with bugs from the genus Rhodnius serving as the main vectors, while in the northeastern region, mainly the genus Triatoma is naturally infected with T. cruzi. Oral infections appear sporadically in some regions of Brazil. Even though the illness is typically present in Latin America, autochthonous cases have been reported in the United States, mainly in the south of the country. The Triatominae subfamily comprises a large number of insect species that are potential vectors of Chagas disease. Triatomines are hematophagous insects, ingesting blood in all life stages. Since the insects play an important role in parasite selection, they also influence the geographical distribution of T. cruzi. The globalization process is one of the most important elements influencing the outcome of Chagas diseases in Brazil. This article outlines the status of reemerging Chagas disease in different regions of Brazil, the distribution of its vectors, and the consequences of global climate changes with respect to interactions of the pathogen with triatomines.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":206280271,"openaccessinfo":{"externalids":{"MAG":"2048828485","ACL":null,"DOI":"10.1089\/vbz.2008.0185","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper reports on natural history and behaviour of the primitively eusocial wasp Ropalidia cyathiformis, which builds small, open, paper carton nests and exhibits an aseasonal nesting cycle. The number of adult wasps on a nest ranges from one to about a hundred, and nests last from a few days to sixteen months or more. Most colonies have a single queen, who is morphologically similar to her workers but has better developed ovaries. Female wasps exhibit several dominance behaviours which are positively correlated with rates of snatching food and building material from incoming foragers,and also of feedinglarvae andbuilding thenest.This suggeststhat behaviourallydominant individuals specialize in performing intra-nidal tasks includingbrood care. Queens are the most behaviourally dominant individuals of their colonies and appear to inhibit worker reproduction and regulate non-reproductive activities of workers using dominance behaviours. Our observations suggest that R. cyathiformis is a typical example ~f a primitively eusocial species, in striking contrast to the congeneric R. marginata which exhibits some features reminiscent of more advanced eusociality.Queens of R. marginataarebehaviourallydocile and appear to use a non-behavioural (probablypheromonal) method of regulating worker reproduction. Non-reproductive activities of workers in R. marginata are regulated in a decentralised, self-organised manner without the involvement of the queen. A comparative study of R. cyathiformis and R. marginata will be valuable in understanding the evolutionary transition from primitive to advanced eusociality in general.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54744494,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Formal psychosocial support programs after weight-loss surgery are limited in scope and availability. Objective This randomized pilot study evaluated the feasibility of a postoperative behavioral intervention program. Materials and methods Postoperative weight-loss surgery patients (N = 50) were recruited from February 2017\u2013July 2017 and randomized to a four-month behavioral program or usual care wait-list. Outcomes evaluated in addition to feasibility included health-related quality of life (Short Form -36), psychosocial functioning and adherence. Secondary outcomes included within-group changes for each outcome. Results Out of eight possible sessions, intervention participants attended a mean of 4.2 sessions. Intervention group participants experienced greater improvements in the social functioning domain of health-related quality of life compared to usual care. Self-reported dietary adherence in the intervention group remained stable, while usual care group dietary adherence declined. Within the intervention group, participants also reported gains in the physical function, pain and general health aspects of quality life from baseline to post-treatment. No differences in weight, mood or other eating behaviors (e.g., loss of control, emotional eating) were evident between groups. Conclusion Though participation in a postoperative behavioral intervention varied, the program helped participants to maintain aspects of quality of life and self-reported adherence to dietary recommendations. Trial registration ClinicalTrials.gov NCT03092479","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":204832490,"openaccessinfo":{"externalids":{"MAG":"2981524268","ACL":null,"DOI":"10.1371\/journal.pone.0223885","PubMedCentral":"6802820","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0223885&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Group 2 innate lymphoid cells (ILC2s) are type 2 cytokine-producing cells that have important roles in helminth infection and allergic inflammation. ILC2s are tissue resident cells, and their phenotypes and roles are regulated by tissue-specific environmental factors. While the role of ILC2s in the lung, intestine, and bone marrow has been elucidated in many studies, their role in adipose tissues is still unclear. Here, we report on the role of ILC2-derived bone morphogenic protein 7 (BMP7) in adipocyte differentiation and lipid accumulation. Co-culture of fat-derived ILC2s with pluripotent mesenchymal C3H10T1\/2 cells and committed white preadipocyte 3T3-L1 cells resulted in their differentiation to adipocytes and induced lipid accumulation. Co-culture experiments using BMP7-deficient ILC2s revealed that BMP7, produced by ILC2s, induces differentiation into brown adipocytes. Our results demonstrate that BMP7, produced by ILC2s, affects adipocyte differentiation, particularly in brown adipocytes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212640635,"openaccessinfo":{"externalids":{"MAG":"3011208477","ACL":null,"DOI":"10.1093\/intimm\/dxaa013","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/intimm\/article-pdf\/32\/6\/407\/33325994\/dxaa013.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The detailed stratigraphic architecture of a Miocene intraplatform prograding carbonate margin, outcropping in Mut Basin, Turkey, was used to build two-dimensional synthetic seismograms by normal ray-tracing and finite-difference, exploding-reflector methods. The synthetic seismic models at various frequencies display the overall prograding architecture of the 1.5-km (0.95-mi) 250-m (820-ft) prograding margin, even at 40-Hz frequency; however, most of the complex stratigraphic architecture is below standard seismic resolution. Sigmoidal outcrop geometries create complex, shingled, seismic reflections that contain pseudodownlap, pseudotoplap, and various truncations at 40-Hz frequency. In addition, reflections that do not correspond to any impedance contrast are generated by a tuning effect within the clinoform. Interference patterns created by the complex impedance distribution create reflections that change phase laterally and cross stratigraphic timelines. Several high-impedance coral buildups at the slope break and on the platform top cause reflections to change phase and amplitude along the timeline. In addition, lateral-impedance variations generate mounded reflections that, in places, cross timelines and resemble seismic images for buildups or anticlinal structures.Several of these resolution problems and interference patterns are reduced by an increase of the frequency. For example, at 80 Hz peak frequency, the sigmoidal geometries are better imaged. Improved resolution was also achieved on the synthetic seismic data simply by dividing trace spacing from 25 to 12.5 m (82 to 39 ft) but keeping the modeling frequency constant, indicating that for stratigraphic interpretation, horizontal seismic resolution is at least as important as vertical seismic resolution. This implies that adjusting the acquisition geometries would improve the seismic resolution without compromising depth by increased frequency. For seismic interpretation, this study shows how little of a complex stratigraphic architecture is truly imaged on seismic data and how complex impedance distribution can create false seismic reflection geometries that impede a correct seismic facies and sequence-stratigraphic interpretation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128713774,"openaccessinfo":{"externalids":{"MAG":"2101406753","ACL":null,"DOI":"10.1306\/11020605192","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We aimed to determine the prevalence of borderline personality disorder (BPD) symptoms in a sample of eating disorder (ED) outpatients and assess how BPD symptoms correlate with severity, distress, and function. A total of 119 individuals were assessed and divided into high BPD symptoms (H-BPD) and low BPD symptoms (L-BPD) using a cut-off score of seven on the McLean Screening for Borderline Personality Disorder (MSI-BPD). Groups were compared on ED diagnosis, age at ED onset, age at assessment, illness duration, body mass index (BMI), ED symptomatology, psychological distress, and psychosocial function. Correlation analyses were performed to assess the relationship between BPD symptoms and these variables. The 45.4% of the participants scored \u22657 on the MSI-BPD, indicating a diagnosis of BPD. There were no differences between the H-BPD (N\u2009=\u200954) and L-BPD (N\u2009=\u200965) groups on age at onset, age at assessment, duration of illness, BMI, or proportion of ED diagnosis. The H-BPD group reported significantly higher ED symptomatology, psychological distress, and poorer psychosocial functioning. MSI-BPD scores were positively associated with these variables. This study suggests a high prevalence of BPD symptoms within outpatients seeking ED treatment, and use of a brief screening instrument for BPD in this group may contribute to a greater understanding of the patient.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251931094,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/pmh.1565","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose.\u2003The purpose was to explore and understand what patients with mild acquired brain injury ((mABI)) consider is effective in a holistic therapy group rehabilitation programme and how the programme affects the rehabilitation process. Methods.\u2003Thematic interviews were conducted with ten informants with diagnosed mABI. They were recruited through purposive sampling after completing a group rehabilitation programme. The data were analysed using a constant comparative method. Results.\u2003The programme provided the informants with awareness of their difficulties in daily life. They were thus motivated to develop compensatory strategies for better function. The core category 'process of change' and four sub-categories were defined: 'the group process', 'the individual', 'family' and 'work'. These describe how the programme supported illness management strategies, e.g. setting and maintaining boundaries, coping with and accepting the hard facts of disability. Body awareness training was important. Work capacity was regarded as a measure of recovery. Social relations concentrated on meaningful exchanges. Conclusion.\u2003When meeting patients with mABI it is important to consider that, despite apparently well functioning; they might suffer from disabling symptoms that affect performance of daily life. A holistic group rehabilitation programme with integrated information properly provides a short cut to facilitating awareness and adjustment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207500152,"openaccessinfo":{"externalids":{"MAG":"2169550110","ACL":null,"DOI":"10.3109\/09638288.2010.528141","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Artiklen undersoger om den vitalistiske kunst er domineret af en mandighedsdyrkelse og om forholdet mellem kunstnernes liv og deres vaerk har haft betydning for den vitalistiske interesse. Dette gores med udgangspunkt i fire kunstneriske vaerker. Sarah Huss Jonsson: The cultivation of gender and body\u00a0within the vitalistic art in Denmark in the beginning of\u00a0the 20th century. Vitalism was a cultural current that emphasized the cultivation of the sensuous human body in close contact with nature. It found expression in philosophy, art and the broad body cultures in the period 1890-1945. The cultivation of the vitality was influenced by the development of the modern society around 1900, which changed materially, mentally, economically, socially as well as in physical culture. In exchange for Christianity, which slowly lost its authority, the vitalists found the meaning of human existence in the cultivation of the active body and outdoor life, while the cultivation of nature \u2013 due to the influence of modern science \u2013 was put in connection with the human health. After 1945 the ideas of vitalism faded away, probably because of Nazi-Germany`s use of a distinct cultivation of the human body and instinct. Within the last decade it has been viewed by the historian Hans Bonde that there exists a significant cultivation of manliness in the vitalism of art, as it is seen in the vitalism of sports and gymnastics. Furthermore it is also claimed by the scholar Lise Praestgaard that the representation of genders in the vitalism of art is affected by the biological view on gender that was dominating at that time. Therefore the genders are claimed to be pictured in dichotomy: man is mainly seen as the rational and active gender, woman is mainly seen as the soft and sensuous one. The purpose of this article is to examine whether these above theses can be seen in such a distinct way in regard to the vitalism of art? Or should it be viewed in a more nuanced way? Finally the article sets out to examine whether there is a possible connection between the lives of the artists and their description of the genders in their vitalistic works. The leading cultivators of vitality in Denmark were a group of painters called \u00bbthe Hellenists\u00ab (1894-1903). Inspired by the old Greeks they gathered each summer to explore the mix between outdoor painting and gymnastics \u2013 all naked. After 1900 vitalism\u00a0was expressed in a wider sense by the painters J. F. Willumsen and Oluf Hartmann and by the sculptors Kai Nielsen and Rudolph Tegner in their respective works such as \u00bbEn bjergbestigerske\u00ab (\u00bbThe mounteneeress \u00ab) (1904), \u00bbJakobs kamp med englen\u00ab (\u00bbJakobs fight with the angel\u00ab) (1908), \u00bbVandmoderen\u00ab (\u00bbThe water-mother\u00ab) (1919-1920) and \u00bbMod lyset\u00ab (\u00bbTowards the light\u00ab) (1909). Beside the effect of the cultivation of the body and nature in modern society, the artists also very much seem to be influenced by their private lives in their description of the genders in their vitalistic works. When it comes to Willumsen, Tegner and Kai Nielsen they all fell in love in the period when they started to express themselves in a vitalistic way. In Willumsen\u00b4s \u00bbEn bjergbestigerske \u00ab this was expressed through an emphasis on the beauty and independence of the woman and the greatness of nature. In Tegner\u00b4s creation of \u00bbMod lyset\u00ab his vision of the healing forces of the sunlight seems to affect him. Here the vitalism is seen in the lofty placement of man, women and child and their naked voluminous, muscular bodies and expressive movements upwards, which put them in touch with the life-giving sunlight. Kai Nielsen\u00b4s love for the woman and the children was inspired by his own family and influenced the vitalistic expression in \u00bbVandmoderen\u00ab. Here the naked, sensuous and fertile woman is in close contact with a lot of lively naked children, which is underscored by its connection with the life-giving water and the children\u00b4s activity. Hartmann represents the cultivation of the \u00bbhomoerotic\u00ab element in painting. For Hartmann it is seen in \u00bbJakobs kamp med englen\u00ab, which expresses the passion, instinct and intensity of vital and powerful men\u00b4s bodily fight. This inspiration Hartmann might have got from his painting teacher, Kristian Zahrtmann, who was homosexual and a cultivator of manliness. It is seen that the woman \u2013 and not only the man - can be seen as the active gender, and also that the cultivation of women and children as well as youth and manliness is a defining factor in vitalism. Therefore this article does not entirely reject the above theses on the cultivation of the genders in the vitalistic art. It rather wants to speak for a modification of the theses.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":193724906,"openaccessinfo":{"externalids":{"MAG":"2592718581","ACL":null,"DOI":"10.7146\/FFI.V24I1.31654","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tagged CMR was used to measure torsion and longitudinal strain in a rodent model of hypertensive heart disease. Long-term ACE inhibitor treatment restored ejection fraction, torsion and longitudinal strain by 24 months of age. Longitudinal strain was the first functional measure to be restored, and this may indicate that longitudinal strain is a sensitive imaging biomarker for assessing the efficacy of treatment with regards to reverse remodeling in hypertension.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":260667526,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.58530\/2022\/4441","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"To develop a tool for use in hearing screening and to evaluate the patient journey towards hearing rehabilitation, responses to the hearing aid rehabilitation questionnaire scales aid stigma, pressure, and aid unwanted addressing respectively hearing aid stigma, experienced pressure from others; perceived hearing aid benefit were evaluated with item response theory. The sample was comprised of 212 persons aged 55 years or more; 63 were hearing aid users, 64 with and 85 persons without hearing impairment according to guidelines for hearing aid reimbursement in the Netherlands. Bias was investigated relative to hearing aid use and hearing impairment within the differential test functioning framework. Items compromising model fit or demonstrating differential item functioning were dropped. The aid stigma scale was reduced from 6 to 4, the pressure scale from 7 to 4, and the aid unwanted scale from 5 to 4 items. This procedure resulted in bias-free scales ready for screening purposes and application to further understand the help-seeking process of the hearing impaired.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16392547,"openaccessinfo":{"externalids":{"MAG":"2559119126","ACL":null,"DOI":"10.4081\/audiores.2016.159","PubMedCentral":"5159752","ArXiv":null},"license":"CCBY","url":"https:\/\/www.audiologyresearch.org\/index.php\/audio\/article\/download\/159\/195","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purified polysaccharide from type III group B Streptococcus contains both a type III-specific determinant and another determinant that is common to strains of serotypes other than type III. The polysaccharide contains sialic acid, galactose, heptose, glucose, glucosamine, and mannose. Serum antibody to this antigen was measured by means of a radioactive antigen-binding assay. Sera from 36 (67.9%) of 53 women with healthy newoborns contained antibody, a prevalence significantly different from that in sera from 15 women (13.3%) whose neonates developed septicemia or meningitis due to type III group B Streptococcus. Complete concordance for presence or absence of anticapsular antibody in sera from 14 women at delivery and in their neonates' cord sera was demonstrated; this concordance indicates transplacental transfer of antibody. Sera from each of four adults with invasive infection who were studied during convalescence contained antibody to the capsular polysaccharide of type III group B Streptococcus. In contrast, antibody was absent from 10 infants who had recovered from bacteremia, septicemia, and\/or meningitis due to type III group B Streptococcus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23820964,"openaccessinfo":{"externalids":{"MAG":"2003318904","ACL":null,"DOI":"10.1093\/INFDIS\/136.SUPPLEMENT.S98","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Under the support of Multi-Regional Input\u2013Output (MRIO) analysis, this study constructs the Embodied Carbon Emission Transfer Network (ECETN) using the input\u2013output tables of 42 sectors in 31 provinces of China in 2012, 2015, and 2017 and applies a series of complex network measurement indicators and analysis methods to describe its evolution features. The results show that the embodied carbon emission transfers between provinces generally narrow over time. With its high clustering coefficient and short average path length, ECETN has small-world characteristics and behaves sensitively, and changes in individual provinces can quickly spread and affect the entire system. In addition, the clustering effect and the spatial spillover structural properties of ECETN are explored based on the block model analysis. Finally, Quadratic Assignment Procedure (QAP) is used to analyze and quantify the contribution of provincial structural roles to ECETN, and it is found that spatial adjacency and differences in strength-in, strength-out, and betweenness centrality have significant positive effects, while differences in eigenvector centrality, clustering coefficient have significant negative effects. The restructuring of domestic trade can help achieve national emission reduction. These findings can provide more insights for the government to formulate future development directions and policies to reduce emissions further.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249294418,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijerph19116794","PubMedCentral":"9180929","ArXiv":null},"license":null,"url":"https:\/\/www.mdpi.com\/1660-4601\/19\/11\/6794\/pdf?version=1654490242","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Autonomous manipulation robots can be valuable aids as interactive agents in the home, yet it has proven extremely difficult to program their behavior. Imitation learning uses data on human demonstrations to build behavioral models for robots. In order to cover a wide range of action strategies, data from many individuals is needed. Acquiring such large amounts of data can be a challenge. Tools for data capturing in this domain must thus implement a good user experience. We propose to use human computation games in order to gather data on human manual behavior. We demonstrate the idea with a strategy game that is operated via a natural user interface. A comparison between using the game for action execution and demonstrating actions in a virtual environment shows that people interact longer and have a better experience when playing the game.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":17511604,"openaccessinfo":{"externalids":{"MAG":"2171767851","ACL":null,"DOI":"10.1145\/2702123.2702552","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This article considers the impact of AIDS on women's roles and responsibilities within the household 'care economy'. In particular, it emphasizes that all interventions aimed at reversing the AIDS epidemic need to take into account the excessive work-load that members of the household, usually women, shoulder in responding to the needs of sick family members. Most notably, gender equality and care economy issues need to be identified by development programmes. There is also a need to implement policies that focus on issues such as treatment, prevention, education, economic empowerment and violence against women. The article argues that unless the care economy and the relations of gender inequality within the household are included in the design, implementation, monitoring and evaluation of such interventions, results will be compromised.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":143375325,"openaccessinfo":{"externalids":{"MAG":"1968831491","ACL":null,"DOI":"10.1080\/03057070500493886","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Registry data typically report incident cases within a certain calendar time interval. Such interval sampling induces double truncation on the incidence times, which may result in an observational bias. In this paper, we introduce nonparametric estimation for the cumulative incidences of competing risks when the incidence time is doubly truncated. Two different estimators are proposed depending on whether the truncation limits are independent of the competing events or not. The asymptotic properties of the estimators are established, and their finite sample performance is investigated through simulations. For illustration purposes, the estimators are applied to childhood cancer registry data, where the target population is peculiarly defined conditional on future cancer development. Then, in our application, the cumulative incidences inform on the distribution by age of the different types of cancer.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210131709,"openaccessinfo":{"externalids":{"MAG":"3000231095","ACL":null,"DOI":"10.1002\/bimj.201800323","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The spectra of brown dwarfs are key to exploring the chemistry and physics that take place in their atmospheres. Late-T dwarf spectra are particularly diagnostic, due to their relatively cloud-free atmospheres and deep molecular bands. With the use of powerful atmospheric retrieval tools applied to the spectra of these objects, direct constraints on molecular\/atomic abundances, gravity, and vertical thermal profiles can be obtained, enabling a broad exploration of the chemical\/physical mechanisms operating in their atmospheres. We present a uniform retrieval analysis on low-resolution Infrared Telescope Facility SpeX near-infrared spectra for a sample of 50 T dwarfs, including new observations as part of a recent volume-limited survey. This analysis more than quadruples the sample of T dwarfs with retrieved temperature profiles and abundances (H2O, CH4, NH3, K, and subsequent C\/O and metallicities). We are generally able to constrain the effective temperatures to within 50 K, the volume mixing ratios for major species to within 0.25 dex, the atmospheric metallicities [M\/H] to within 0.2, and the C\/O ratios to within 0.2. We compare our retrieved constraints on the thermal structures, chemistry, and gravities of these objects with predictions from self-consistent radiative-convective equilibrium models and find, in general, though with substantial scatter, consistency with solar composition chemistry and the thermal profiles of the neighboring stellar FGK population. Objects with notable discrepancies between the two modeling techniques and potential mechanisms for their differences, be they related to the modeling approach or physically motivated, are discussed more thoroughly in the text.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":249282464,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3847\/1538-4357\/ac786c","PubMedCentral":null,"ArXiv":"2206.01199"},"license":"CCBY","url":"https:\/\/doi.org\/10.3847\/1538-4357\/ac786c","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Xenogenic antibodies with reactivity for surface determinants of the guinea pig line-10 hepatocarcinoma were isolated by using cellular immunoadsorbents prepared by coupling formalin-treated line-10 cells to diethylaminoethyl cellulose. Antibodies prepared in this manner exhibited a high degree of reactivity for line-10 surface determinants. These antibodies also reacted with surface determinants of the syngeneic line-1 hepatocarcinoma. Further specificity of antibody reactivity to the line-10 hepatocarcinoma was accomplished by passage of the antibodies through cellular immunoadsorbents prepared with syngeneic line-1 hepatocarcinoma cells. By direct binding studies, these antibodies showed significantly reduced reactivity for line-1 cells and no reactivity for guinea pig spleen cells or for the unrelated murine EL-4 lymphoma. By a competitive radioimmunoassay, these antibodies reacted only with determinants expressed on the surfaces of line-10 cells and not on syngeneic line-1, L2C, spleen, thymus; or xenogeneic EL-4 cell surfaces. In a similar manner, line-10-associated antigens were detected in ascites fluid derived from line-10 tumor-bearing animals. The sequential use of immunoadsorbents made of antigenically distinct but syngeneic tumor cells made it possible to prepare antibodies with restricted reactivity for line-10-associated antigens and should be applicable to the isolation of \"tumor-specific\" antibodies in other systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13417789,"openaccessinfo":{"externalids":{"MAG":"1905566753","ACL":null,"DOI":"10.4049\/jimmunol.124.3.1141","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.aai.org\/jimmunol\/article-pdf\/124\/3\/1141\/1011924\/1141.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Large databases\u202fof\u202flegacy\u202fhydrocarbon\u202freservoir\u202fand\u202fwell data\u202fprovide an\u202fopportunity\u202fto use\u202fmodern data mining\u202ftechniques\u202fto improve our understanding of\u202fthe subsurface\u202fin\u202fthe\u202fpresence of uncertainty and improve predictability of reservoir properties.\u202fA data\u202fmining approach provides a way to screen dependencies in reservoir and fluid data and enable\u202fsubsurface specialists\u202fto\u202festimate absent properties in partial or incomplete datasets. This\u202fallows\u202ffor uncertainty\u202fto\u202fbe managed\u202fand reduced.\u202fAn\u202fimprovement in reservoir\u202fcharacterisation using\u202fmachine learning\u202fresults from the capacity of machine learning methods to detect and model hidden dependencies in large multivariate datasets\u202fwith noisy and missing data.\u202f\u202fThis study presents a workflow applied to a large basin-scale reservoir characterization database. The study aims to understand the dependencies between reservoir attributes in order to allow for predictions to be made to improve the data coverage. The machine learning workflow comprises the following steps: (i) exploratory data analysis; (ii) detection of outliers and data partitioning into groups showing similar trends using clustering; (iii) identification of dependencies within reservoir data in multivariate feature space with self-organising maps; and (iv) feature selection using supervised learning to identify relevant properties to use for predictions where data are absent. This workflow provides an opportunity to reduce the cost and increase accuracy of hydrocarbon exploration and production in mature basins.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":246568528,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/en15031070","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/15\/3\/1070\/pdf?version=1644293543","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aims. Colorectal cancer (CRC) screening is underutilized. Increasing CRC screening rates requires interventions targeting multiple barriers at each level of the healthcare organization (patient, provider, and system). We examined groups of primary care providers (PCPs) based on perceptions of screening barriers and the relationship to CRC screening rates to inform approaches for conducting barrier assessments prior to designing and implementing quality improvement interventions. Methods. We conducted a retrospective cohort study linking EHR and survey data. PCPs with complete survey responses for questions addressing CRC screening barriers were included (N = 166 PCPs; 39,430 patients eligible for CRC screening). Cluster analysis identified groups of PCPs. Multivariate logistic regression estimated odds ratios and 95% confidence intervals for predictors of membership in one of the PCP groups. Results. We found two distinct groups: (1) PCPs identifying multiple barriers to CRC screening at patient, provider, and system levels (N = 75) and (2) PCPs identifying no major barriers to screening (N = 91). PCPs in the top half of CRC screening performance were more likely to identify multiple barriers than the bottom performers (OR, 4.14; 95% CI, 2.43\u20137.08). Conclusions. High-performing PCPs can more effectively identify CRC screening barriers. Targeting high-performers when conducting a barrier assessment is a novel approach to assist in designing quality improvement interventions for CRC screening.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16242085,"openaccessinfo":{"externalids":{"MAG":"2568202400","ACL":null,"DOI":"10.1155\/2017\/1619747","PubMedCentral":"5259663","ArXiv":null},"license":"CCBY","url":"http:\/\/downloads.hindawi.com\/journals\/grp\/2017\/1619747.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This cross-sectional descriptive study, aimed at accessing the accuracy of Pap smear in diagnosing cervical precancerous lesions, was carried out between 3 January and 30 April 2017. All women screened for cervical dysplasia by means of Pap smear with biopsy done for confirmation were subsequently recruited. Data were analysed using SPSS 20.0. A total of 231 women were screened for cervical dysplasia using Pap smear with 75 biopsies performed. Cervical dysplasia was noticed in 54 cases. The sensitivity, specificity, positive predictive and negative predictive values of Pap smear were 55.5%, 75%, 88.2% and 33.3%, respectively. The sensitivity of Pap smear remains low. Therefore, biopsy should be done in cases of macroscopic cervical architectural changes irrespective of the result of the Pap smear. Moreover, to reduce the number of women with cervical precancerous lesions, the government should make available financial resources to set up HPV vaccination programmes rather than screening programmes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52280945,"openaccessinfo":{"externalids":{"MAG":"2891356524","ACL":null,"DOI":"10.1177\/0049475518798532","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0049475518798532","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Epidemiological studies in cardiology often are confronted with the need of modeling the population dependence of the development of cardiovascular diseases (CVD) on a complex of influencing risk factors (RF). A method for assessment the CVD population risk is proposed, the calculation of which assumes the population group as the unit of analysis, and the prevalence of risk factors in this group as the input data. Calculation of the population risk is build taking into account predictive value of risk factors basing on their contribution to CVD prevalence. The method of calculation of population risk, examples of its application (arterial hypertension in working population, ethnic groups, ischemic heart disease in open and working population), as well as discussion of its strong and weak sides are presented in this review.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":197666416,"openaccessinfo":{"externalids":{"MAG":"2963135484","ACL":null,"DOI":"10.18087\/cardio.2019.7.2606","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/lib.ossn.ru\/jour\/article\/download\/749\/458","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Global magnetic fields of active solar-like stars are, nowadays, routinely detected with spectropolarimetric measurements and are mapped with Zeeman Doppler imaging (ZDI). However, due to the cancellation of opposite field polarities, polarimetry only captures a tiny fraction of the magnetic flux and cannot assess the overall stellar surface magnetic field if it is dominated by a small-scale component. The analysis of Zeeman broadening in high-resolution intensity spectra can reveal these hidden complex magnetic fields. Historically, there were very few attempts to obtain such measurements for G dwarf stars due to the difficulty of disentangling the Zeeman effect from other broadening mechanisms affecting spectral lines. Here, we developed a new magnetic field diagnostic method based on relative Zeeman intensification of optical atomic lines with different magnetic sensitivity. By using this technique, we obtained 78 field strength measurements for 15 Sun-like stars, including some of the best-studied young solar twins. We find that the average magnetic field strength Bf drops from 1.3\u22122.0 kG in stars younger than about 120 Myr to 0.2\u22120.8 kG in older stars. The mean field strength shows a clear correlation with the Rossby number and with the coronal and chromospheric emission indicators. Our results suggest that magnetic regions have roughly the same local field strength B\u2004\u2248\u20043.2 kG in all stars, with the filling factor f of these regions systematically increasing with stellar activity. In comparing our results with the spectropolarimetric analyses of global magnetic fields in the same stars, we find that ZDI recovers about 1% of the total magnetic field energy in the most active stars. This figure drops to just 0.01% for the least active targets.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":211296645,"openaccessinfo":{"externalids":{"MAG":"3008296212","ACL":null,"DOI":"10.1051\/0004-6361\/201937185","PubMedCentral":null,"ArXiv":"2002.10469"},"license":null,"url":"https:\/\/www.aanda.org\/articles\/aa\/pdf\/2020\/03\/aa37185-19.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Expanded, non-coding RNAs can exhibit a deleterious gain-of-function causing human disease through abnormal interactions with RNA-binding proteins. Myotonic dystrophy (DM), the prototypical example of an RNA-dominant disorder, is mediated by trinucleotide repeat-containing transcripts that deregulate alternative splicing. Spliceopathy has therefore been a major focus of DM research. However, changes in gene expression, protein translation and micro-RNA metabolism may also contribute to disease pathology. The exciting finding of bidirectional transcription and non-conventional RNA translation of trinucleotide repeat sequences points to a new scenario, in which DM is not mediated by one single expanded RNA transcript, but involves multiple pathogenic elements and pathways. The study of the growing number of human diseases associated with toxic repeat-containing transcripts provides important insight into the understanding of the complex pathways of RNA toxicity. This review describes some of the recent advances in the understanding of the molecular mechanisms behind DM and other RNA-dominant disorders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5840276,"openaccessinfo":{"externalids":{"MAG":"2165247158","ACL":null,"DOI":"10.1093\/hmg\/ddr343","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/hmg\/article-pdf\/20\/R2\/R116\/1789882\/ddr343.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The aim of our study is evaluating occupational exposure in a factory named \"Poligrafico Zecca dello Stato\" in Foggia. The workers had a occupational disease \"chlorine related parodontal disease\" indemnified by INAIL (Italian Occupational Assurance). The study demonstrated the workers have been indemnified worked as engineer, drying and electrolysis process employed. The study showed that the workers indemnified without legal action were different in respect of workers that take legal action, because the last showed, paradoxically, a chlorine occupational exposure. The explanation of this paradox might be the production cycle non acknowledge by operators.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45418751,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is shown that polar cap arcs of typical electron energy \u2264 1 keV can be produced by the downward acceleration of polar rain electrons by parallel potential drops on open field lines. The formation of these arcs is the result of current response to meso-scale velocity shear structures in the ionospheric convection that is not matched at the magnetosphere. The theory predicts the formation of a pair of meso-scale field-aligned currents (one upward and one downward) for each ionospheric shear structure. The theory does not require a bifurcated magnetic configuration for each polar cap arc; hence, it can account for the frequently encountered multiple polar cap arcs without cutting up the magnetosphere into a large number of open and closed magnetic field regions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140628744,"openaccessinfo":{"externalids":{"MAG":"1994387992","ACL":null,"DOI":"10.1029\/GL016I007P00743","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The first antiviral nucleoside 5-iodo-2'-deoxyuridine (IDU) against herpes simplex virus type 1 and type 2 is a thymidine analogue, i.e. the C5 methyl group is replaced by an I atom. The structure of the self-complementary hexamer d[CACG(IDU)G] was determined by single-crystal X-ray diffraction techniques. The orthorhombic crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 18.16, b = 30.03, c = 41.99 A. Refinement in the resolution range 20-1.3 A converged with a final R1 = 0.167, including 43 water molecules and two cobalt hexammine complexes. The incorporation of a large I atom has only minor consequences for the overall structure as is noticed in the IDU.A base pairs, which are of the common Watson-Crick type. To contribute to the still puzzling mechanism of this historically important agent, details of base stacking, helical parameters, hydration etc. have been studied. A general scheme of cobalt hexammine-binding modes in Z-DNA is provided, revealing similar binding modes for the reported structure.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-18":1,"unknown":2}},"corpusid":8819900,"openaccessinfo":{"externalids":{"MAG":"2064309317","ACL":null,"DOI":"10.1107\/S0907444903012381","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Democratic innovations, such as the introduction of deliberative mini-publics, have attracted increasing attention. The assumption is that involving citizens more directly in policymaking offers a way to address the widespread decline in public trust in the democratic process and traditional\n forms of engagement, such as voting in elections. While a thriving literature discusses the merits of mini-publics from a citizen perspective, scholars have neglected the views of policymakers. To fill the gap, we draw on two recent surveys conducted in Finland to examine citizens' and\n policymakers' attitudes to mini-publics. The data show that citizens report high levels of trust in the capacity of a deliberative citizen body to produce meaningful policies. However, policymakers are more sceptical about their value. This finding is important because it may well have\n implications for the willingness of policymakers to create mini-publics and take their recommendations into account.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":218960420,"openaccessinfo":{"externalids":{"MAG":"3022798779","ACL":null,"DOI":"10.1332\/030557320x15870515357288","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Humane Co-house design-led research project presents a new typology for shared medium-density housing sited in a city-fringe Wellington suburb. The research argues communal living can be utilised to achieve smaller dwellings, a high medium-density grain, a humane living environment and a new form of social interaction that home buyers will find desirable.\u00a0Buying a home is difficult throughout New Zealand and Wellington is no exception. Inner-city apartment blocks lack individuality, space for growing families and a sense of community and autonomy. While research shows houses in outer suburbs are perceived to provide these, they come at a high price and there are low amounts of available stock. There is potential for city-fringe suburbs adjacent to the inner city to accommodate more dwellings, creating available housing stock that is appealing to buyers who would otherwise be looking at expensive suburban houses.\u00a0The research begins with the current attitudes and preferences within the New Zealand housing context, and suggests that the appeal of the traditional detached suburban house is intertwined with a desired balance of private space to common space. The research designs and develops a new typology that attempts to achieve this balance, but with smaller dwellings at a high medium-density.\u00a0Through design-led research an architectural definition and manifestation of a humane dwelling is formed. This focuses on a balance of private space and common space.\u00a0Qualities of common and private spaces within a dwelling are explored through literature and design tests. Evaluation of design case studies produced from research, tests and iterations draws conclusions about how communal living can be utilised by different demographics to achieve a new type of social interaction, and a basic level of affordability that will resonate in the current context. The final design case study was critically reflected upon in terms of a theoretical client that over time might transition through three demographic groups \u2013 a working young person or couple, a family and a retired person or couple. In this way the design case study produced was considered as a flexible and long-term dwelling, resulting in a humane and appealing home for occupants at different stages of life.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128808059,"openaccessinfo":{"externalids":{"MAG":"1580993101","ACL":null,"DOI":"10.26686\/wgtn.17007874.v1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/openaccess.wgtn.ac.nz\/articles\/thesis\/The_humane_co_house\/17007874\/1\/files\/31461325.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The molybdenum nitrido complex 15NMo[N(R)Ar]3 (where R = C(CD3)2CH3, Ar = 3,5-C6H3Me2) reacted with the anhydride of trifluoroacetic acid at room temperature to afford the correspondent organonitrogen compound in almost quantitative yield without the necessity of using additional reagents to achieve the C-N coupling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33553770,"openaccessinfo":{"externalids":{"MAG":"2024819329","ACL":null,"DOI":"10.1039\/B305774G","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective With drug trials starting soon, responsive, relevant, and patient-friendly biomarkers are highly needed in facioscapulohumeral dystrophy (FSHD). Our objective was to assess muscle ultrasound (MUS) as an imaging biomarker in patients with FSHD. Methods One-year observational, longitudinal study of both quantitative and qualitative MUS changes in FSHD. Results Twenty-two patients with symptomatic FSHD1 underwent a clinical examination and MUS at baseline and after 1-year follow-up. The qualitative MUS sum score increased from 18.59 to 20.32 (p = 0.005) and the quantitative MUS sum z scores increased from 19.96 to 24.72 (p = 0.003). The clinical scores did not change over 1 year. Muscle echogenicity correlated with the FSHD clinical score at baseline (r = 0.61, p = 0.002). Conclusions MUS shows a significant increase in echogenicity in FSHD over 1 year. Both quantitative and qualitative MUS correlate cross-sectionally with clinical severity in FSHD and identify structural muscle changes in a clinically stable group of patients. MUS thus seems a potentially responsive biomarker that could be standardized between centers. We recommend its use in therapeutic trials. Classification of evidence This study provides Class I evidence that in patents with FSHD1, MUS findings correlate with baseline FSHD clinical scores.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212416528,"openaccessinfo":{"externalids":{"MAG":"3009599653","ACL":null,"DOI":"10.1212\/WNL.0000000000009211","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Objective: This article aimed to evaluate the efficacy of arthroereisis using synthetic polyethylene implants to correct excessive valgus deformity in pediatric patients with flexible valgus flatfoot. Methods: Retrospective study of 20 pediatric patients with flexible valgus flatfoot, totaling 23 feet, between five and 14 years old, operated between January 2009 and July 2016. Clinical evaluations were performed by the Valenti podoscopic classification and the American Orthopaedic Foot & Ankle Society criteria, based on radiographic images and podoscopic analysis. These patients underwent surgical treatment with the introduction of a synthetic implant in the sinus tarsi. Multiple linear regression analysis with Backward selection of variables, angles of pre and postoperative of radiographic images of the patients submitted to arthroereisis were performed. Results: The arthroereisis with interposition of synthetic material was satisfactory, considering that 91% of the cases presented clinical and radiographic improvement, with correction of angles and improvement in deformity degrees. Two cases presented implant loosening. The variables of the Bordelon and Pitch angles significantly influenced (p < 0,05) the improvement of the correction of deformity degrees. Conclusion: The arthroereisis with the interposition of synthetic polyethylene material showed to be an effective technique for flexible flatfoot in symptomatic pediatric patients. Level of Evidence II, Prognostic studies - Investigating the Effect of a Patient Characteristic on the Outcome of Disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":226227343,"openaccessinfo":{"externalids":{"MAG":"3093965177","ACL":null,"DOI":"10.1590\/1413-785220202805234176","PubMedCentral":"7580296","ArXiv":null},"license":"CCBYNC","url":"http:\/\/www.scielo.br\/j\/aob\/a\/YQL6ZTMLFDJMP3tMb9wcXkr\/?lang=en&format=pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Aerodynamic and structural dynamic performance analysis of modern wind turbines are routinely estimated in the wind energy field using computational tools known as aeroelastic codes. Most aeroelastic codes use the blade element momentum (BEM) technique to model the rotor aerodynamics and a modal, multi-body or the finite-element approach to model the turbine structural dynamics. The present work describes the development of a novel aeroelastic code that combines a three-dimensional viscous\u2013inviscid interactive method, method for interactive rotor aerodynamic simulations (MIRAS), with the structural dynamics model used in the aeroelastic code FLEX5. The new code, called MIRAS-FLEX, is an improvement on standard aeroelastic codes because it uses a more advanced aerodynamic model than BEM. With the new aeroelastic code, more physical aerodynamic predictions than BEM can be obtained as BEM uses empirical relations, such as tip loss corrections, to determine the flow around a rotor. Although more costly than BEM, a small cluster is sufficient to run MIRAS-FLEX in a fast and easy way. MIRAS-FLEX is compared against the widely used FLEX5 and FAST, as well as the participant codes from the Offshore Code Comparison Collaboration Project. Simulation tests consist of steady wind inflow conditions with different combinations of yaw error, wind shear, tower shadow and turbine-elastic modeling. Turbulent inflow created by using a Mann box is also considered. MIRAS-FLEX results, such as blade tip deflections and root-bending moments, are generally in good agreement with the other codes. Copyright \u00a9 2017 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":114811525,"openaccessinfo":{"externalids":{"MAG":"2593307556","ACL":null,"DOI":"10.1002\/WE.2085","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Foreign Bodies: Military Medicine, Modernism and Melodrama traces how representations of warfare in the modernist novel, girls' romances, nursing memoirs, and war films dramatize the humanitarian disaster of war through the figure of woman. My analysis focuses on the visual and literary poetics of violence as troped in and through the bodies of combat nurses. The \"uncanny\" serves as a lens to explore the complex links between gendered war work and the radical transgression of the boundaries of the nation state and the body experienced during wartime. To establish the unique explanatory power of the uncanny for gender issues, I trace how feminist and postcolonial theorists have revised Freud's analysis of the uncanny. I trace medical metaphors of wounding and infection in the novel and various cinematic adaptations of A Farewell to Arms (1932, 1951, 1957, 1996). I read the letters and diaries of World War I nurse Agnes von Kurowsky against the censored memoirs of American nurses Mary Borden and Ellen La Motte. I show how the uncanny aesthetic adopted by Ernest Hemingway in A Farewell to Arms is subverted by these women writers. I explore how these uncanny aesthetics also manifest in adolescent nursing romances from Sue Barton to Cherry Ames. With the onset of World War II, I trace how the discourse of foreign bodies in relation to the metaphor of malaria in the South Pacific. Focusing on the portrayal of the Japanese foreign body, often encoded through off-screen sound, I demonstrate how medical metaphors of malaria operate in films portraying nursing in the South Pacific such as So Proudly We Hail (1943) and Cry Havoc (1943). Turning to the Korean and Vietnam Wars, I explore the representation of post-traumatic stress disorder in M*A*S*H (1970)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":191072838,"openaccessinfo":{"externalids":{"MAG":"774882718","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrodynamics and special relativity are so deeply interconnected that it is difficult decide which of them is the logical consequence of the other, without running the risk of circular reasoning. Following the historical development by introducing electromagnetism phenomenologically first, this issue is not resolved but at best minimized, because even the Lorentz force law itself is fundamentally relativistic. Here we propose a derivation of Maxwell's equations at a beginning graduate level with the goal of circumventing this difficulty. Based on prior work that establishes special relativity independently of any electrodynamic postulates, it is indeed possible to derive Maxwell's equations from relativity by adding suitable assumptions. The contribution of the present work is to choose these assumptions in such a way that they can be regarded as extensions of the same postulates on which special-relativistic point-particle dynamics itself is based in the first place. The biggest leap is to extend the law of energy- and momentum conservation to the electromagnetic field itself. This hinges on the energy\u2013momentum tensor, and the fact that the latter must account not only for the Lorentz force on a charge, but also for the forces exerted by that same charge on its environment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248475225,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1361-6404\/ac663a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A 90-year-old woman was referred to our hospital because of dyspnea with pleural effusion that was detected using a chest X-ray. Pleural fluid cell block specimens from the left pleural effusion were shown to be an adenocarcinoma harboring an epidermal growth factor receptor(EGFR)gene mutation(L858R). Erlotinib was administered and the patient responded to treatment for 15 months. Subsequent re-accumulation of the left pleural effusion was detected, and re-evaluation using cell block specimens revealed EGFR T790M mutation positivity. Osimertinib was initiated and the patient responded to treatment for 11 months. Re-evaluation of the left pleural effusion upon failure of osimertinib treatment revealed EGFR T790M mutation negativity. Hence this report summarizes the case of osimertinib therapy being administered to a 90-year-old patient who had EGFR T790M mutation positivity based on a pleural fluid cell block.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52115925,"openaccessinfo":{"externalids":{"MAG":"2989782993","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The generation of biomedical waste has increased many times after the SARS Cov2 commencement. The biomedical waste generated from COVID-19 Patients is very infectious and contaminated. Thus, it is a big challenge with all stakeholders to avoid spreading of COVID-19 through it. This requires monitoring the complete cycle to the grave to be monitored from the cradle, if the spreading needs to be controlled. The COVID-19 waste generation, collection, storage, transportation and disposal is a big challenge withall stakeholders including isolation wards, quarantine centres, sample collection centres, laboratories, urban local bodies, and the Common Bio-medical Waste Treatment Facility (CBWTF) respectively. As its a novel virus and WHO has instructed that proper guidelines need to be followed with regards to COVID-19biomedical waste generation and its safe disposal. The Government of India has separately developed the Guidelines for the handling of COVID-19 biomedical waste, which needs to be followed besides BiomedicalRules, 2016 so that Corona spread through this can be controlled. Owing to its novel origin and least information about its behaviour, thus it is extremely important to take all precautions possible till we get some medical treatment.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":222104414,"openaccessinfo":{"externalids":{"MAG":"3035246083","ACL":null,"DOI":"10.9734\/ajee\/2020\/v13i130171","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/journalajee.com\/index.php\/AJEE\/article\/download\/248\/495","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In the 1790s the radical thinkers Tom Paine and Thomas Spence were among the first to advocate the payment of a Basic Income as a right to all citizens. In this paper we outline Paine's position, as set out in The Rights of Man (1791-1792) and in Agrarian Justice (1795), and compare it with the case made by Spence in The Rights of Infants (1797). We show that their arguments were surprisingly complex, and included utilitarian grounds for supporting Basic Income in addition to an assertion of the individual's right to existence and to a share in the produce of nature.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":155078421,"openaccessinfo":{"externalids":{"MAG":"2120303080","ACL":null,"DOI":"10.1400\/54091","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper we propose a taxonomy for image authentication techniques that takes into account three different features: the level of integrity verification, the approach to the generation of the authenticator and the capability of localizing manipulated areas. The goal is to revise the current and very heterogeneous bibliography on this topic, and to define a set of basic requirements for an authentication service, in order to identify which ones have already been met and which ones remain challenging. The major algorithms proposed in the last decade are examined according to the classification criteria; advantages and drawbacks of the possible approaches are reported. In particular, we investigate the relationship between the well established digital signature techniques and the emerging watermarking approaches. As a result, we propose a methodological approach to the design of robust, secure and efficient authentication algorithms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":26460263,"openaccessinfo":{"externalids":{"MAG":"2102822278","ACL":null,"DOI":"10.1109\/ICIAP.2001.957065","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Trauma exposure and low self-control are robustly associated with youth antisocial\/criminal problems, but the interrelation of these constructs is unclear when taking into account both traumatic events and reactions. The objective of the present study is to examine self-control mediation effects related to trauma and juvenile delinquency, conduct disorder, crime seriousness, and aggression outcomes. The sample consisted of N = 388 male youth from Portugal (age, M = 16.01 years, SD = 1.03, age range = 13\u201318 years). Path analysis procedures revealed that self-control partially mediates the relation between trauma events and the examined outcomes and fully mediates the relation between trauma reactions and the examined outcomes. Research on youth trauma should examine both trauma events and trauma reactions because they have differential effects on low self-control and antisocial\/criminal outcomes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231611053,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijerph18020567","PubMedCentral":"7826820","ArXiv":null},"license":null,"url":"https:\/\/www.mdpi.com\/1660-4601\/18\/2\/567\/pdf?version=1610429966","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"An overview of Theory of Mind and its role and impacts on student learning in public school education environments is pre- sented. Also presented is a brief look at the current research pertaining to Theory of Mind and its relationship to children and their developmental processes. Further analyzed are ways social skills are impacted by Theory of Mind in accordance with age related behavioral processes. Further presented are implica- tions for classrooms and applications are described that include roles and impacts on certain groups including students, teachers, and administrators. Solutions are offered to help professionals develop the most effective programs through consistent, research based methodologies and philosophies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":146158526,"openaccessinfo":{"externalids":{"MAG":"2184807051","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The genus Agave L. comprises about 300 species and is characterized by a bimodal karyotype with basic chromosome number x = 30 (5L and 25S) and ploidy levels ranging from diploids to hexaploids. Species of this genus have low heterochromatin content, visualized as CMA+\/DAPI- bands, and one 5S and 35S ribosomal DNA sites per haploid genome. However, in silico analysis of the repetitive fraction of the Agave hybrid 11648 (2n = 2x = 60, 8.35 Mpb) revealed that ~ 67.6% of its genome is composed of different repetitive DNA families. Among the most abundant elements are Maximus, TAR and Tork (Copia), and Athila, Chromovirus and Ogre (Gypsy) LTR-retrotransponsons, as well as, a single family of satellite DNA. In order to investigate the repetitive DNA distribution in this bimodal karyotype, these seven elements were labeled by nick translation and hybridized in situ to the hybrid 11648 metaphases. The satellite DNA was located at centromeric regions of all chromosomes, however a subset of the small chromosomes had stronger signals. All transposable elements showed a dispersed distribution, mostly non-uniform along chromosomes arms. Athila and Maximus lineages showed stronger labeling of interstitial and distal regions of the long arms of large chromosomes, while Tork and especially TAR labeled more intensely the proximal regions. Small chromosomes showed variable labeling with all repetitive elements, generally weaker than large chromosomes. Together, these data revealed that different LTR retrotransposon lineages accumulated differentially, and usually more abundantly, in the large chromosomes, whereas the centromeric satellite DNA showed a quantitative variation between chromosomes, but not related to the bimodal condition of this karyotype.Financial support: CAPES, CNPq.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":92795516,"openaccessinfo":{"externalids":{"MAG":"2886600540","ACL":null,"DOI":"10.5433\/1679-0367.2017V38N1SUPLP233","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Osteoporosis is a relative contraindication for osseointegrated implants. This article describes a patient with severe osteoporosis who underwent implant therapy in the mandible. The treatment was carried out in a conventional manner, except for a longer healing period (6 months). All implants had clinically osseointegrated. Furthermore, there was no problem after the superstructure was placed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13371116,"openaccessinfo":{"externalids":{"MAG":"64790631","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a robust methodology for grounding vocabulary in robots. A social language grounding experiment is designed, where, a human instructor teaches a robotic agent the names of the objects present in a visually shared environment. Any system for grounding vocabulary has to incorporate the properties of gradual evolution and lifelong learning. The learning model of the robot is adopted from an ongoing work on developing systems that conform to these properties. Significant modifications have been introduced to the adopted model, especially to handle words with multiple meanings. A novel classification strategy has been developed for improving the performance of each classifier for each learned category. A set of six new nearest-neighbor based classifiers have also been integrated into the agent architecture. A series of experiments were conducted to test the performance of the new model on vocabulary acquisition. The robot was shown to be robust at acquiring vocabulary and has the potential to learn a far greater number of words (with either single or multiple meanings).","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":18139490,"openaccessinfo":{"externalids":{"MAG":"2395860675","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A method for determining the optimal two-dimensional spatial placement of multiple sensors participating in a robot perception task is introduced in this paper. This work is motivated by the fact that sensor data fusion is an effective means of reducing uncertainties in sensor observations, and that the combined uncertainty varies with the relative placement of the sensors with respect to each other. The problem of optimal sensor placement is formulated and a solution is presented in two dimensional space. The algebraic structure of the combined sensor uncertainty with respect to the placement of sensors is studied. A necessary condition for optimal placement is derived and this necessary condition is used to obtain an efficient closed-form solution for the global optimal placement. Numerical examples are provided to illustrate the effectiveness and efficiency of the solution. >","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":32492653,"openaccessinfo":{"externalids":{"MAG":"2149605683","ACL":null,"DOI":"10.1109\/21.376491","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Polymorphisms in one-carbon metabolism genes may influence the susceptibility to hepatocellular carcinoma (HCC). In the present study, we studied methylenetetrahydrofolate reductase (MTHFR) tagging polymorphisms in 584 HCC cases and 923 controls. Polymerase chain reaction was harnessed to detect MTHFR genotype. Overall, our results showed that genotype distribution of MTHFR rs4846048 and rs4845882 polymorphisms was not different between HCC patients and controls. MTHFR rs9651118 and rs1801133 loci were protective factors for HCC (rs9651118: CT vs. TT: adjusted odds ratio (OR) = 0.67, 95% confidence interval (CI): 0.49\u20130.90, P=0.008 and TC\/CC vs. TT: adjusted OR = 0.70, 95% CI: 0.53\u20130.93, P=0.015; rs1801133: GA vs. GG: adjusted OR = 0.72, 95% CI: 0.54\u20130.97, P=0.031, AA\/GA vs. GG: adjusted OR = 0.76, 95% CI: 0.57\u20130.99, P=0.045). However, MTHFR rs3753584 locus was a candidate for susceptibility to HCC (CT vs. TT: adjusted OR = 1.67, 95% CI: 1.20\u20132.32, P=0.003 and TC\/CC vs. TT: adjusted OR = 1.59, 95% CI: 1.15\u20132.20, P=0.005). Results of haplotype analysis suggested that MTHFR Grs1801133Trs3753584Grs4845882Ars4846048Trs9651118 was associated with the risk of HCC (OR = 1.55, 95% CI: 1.16\u20132.07, P=0.003). The power of our study also confirmed these associations (the value of power >0.80). In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population. In future, our findings should be further validated in additional case\u2013control studies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":207942194,"openaccessinfo":{"externalids":{"MAG":"2979505356","ACL":null,"DOI":"10.1042\/BSR20192517","PubMedCentral":"6852349","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The effective climate sensitivity in the Department of Energy's Energy Exascale Earth System Model (E3SM) has decreased from 5.3 K in version 1 to 4.0 K in version 2. This reduction is mainly due to a weaker positive cloud feedback that leads to a stronger negative radiative feedback. Present-day atmosphere-only experiments with uniform 4 K sea surface temperature warming are used to separate the contributions of individual model modifications to the reduced cloud feedback. We find that the reduced cloud feedback is mostly driven by changes over the tropical marine low cloud regime, mainly related to a new trigger function for the deep convection scheme and modifications in the cloud microphysics scheme. The new trigger function helps weaken the low cloud reduction by increasing the cloud water detrainment at low levels from deep convection under warming. Changes to the formula of autoconversion rate from liquid to rain and an introduced minimum cloud droplet number concentration threshold in cloud microphysical calculations help sustain clouds against dissipation by suppressing precipitation generation with warming. In the midlatitudes, the increased Wegener-Bergeron-Findeisen (WBF) efficiency strongly reduces present-day liquid water and leads to a stronger negative cloud optical depth feedback. The reduced trade cumulus cloud feedback in v2 is closer to estimates from recent observational and large-eddy modeling studies but might not be due to the right physical reasons. The reduced mid-latitude cloud feedback may be more plausible because more realistic present-day mixed-phase clouds are produced through the change in the WBF efficiency.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":259282100,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study focuses on comparing the growth trajectory of border and non-border school districts regarding their fifth-grade students' performance on a standardized reading test. Using a growth hierarchical linear model, we investigated the effect of time, school location, and their interaction on students' reading performance through the State of Texas Assessment of Academic Readiness (STAAR) reading test in five recent school years. It was found that border school students lagged behind in reading at the initial stage when STAAR was first administered. As time went by, the gap between border and non-border district students' reading performance remained. Implications for teaching pedagogy and research are discussed regarding the preparation of border district students to become bilingual, bicultural, and biliterate.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":149505422,"openaccessinfo":{"externalids":{"MAG":"2911336330","ACL":null,"DOI":"10.3390\/EDUCSCI9010038","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The increased prevalence of Narcissistic personality and development of \npsychobiological approaches in recent decades has led to a shift in prevention and treatment of this \ndisorder. So, current research is aimed at determining the role of temperament-character dimensions and \nbrain-behavioral systems in predicting narcissistic personality characteristics. \nMaterials & Methods: This correlational descriptive study used simple random sampling method and \nincluded 368 female students of Urmia University dormitories in 2015. The study tools were Carver & \nWhite Behavioral Activation System \/ Behavioral Inhibition System Scale, Temperament-Character \nInventory (TCI 125) and Ames Narcissistic Personality Inventory (NPI \u2013 16). Statistical tests including \ndescriptive statistics, correlation coefficient and regression equation were applied to analyze data with \nSPSS software version 22. \nResults: There was a significant correlation between narcissistic and temperament, all four dimensions \n(NS, HA, RD & P), two dimensions of Character (ST & CO) (p<0.01), and two subscales of BAS (RR, \nFS &) (p<0.05). Regression of narcissistic personality characteristics would be predicted by 8 variables. \nConclusion: Narcissistic personality characteristics would be predicted by 6 variables of temperament \nand character dimensions and two variables of brain-behavioral systems","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":148901932,"openaccessinfo":{"externalids":{"MAG":"2739312361","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper investigates a novel flexible job-shop scheduling problem, where the machines have batch-processing capacity, but incompatible jobs cannot be processed in a batch (FJSPBI) simultaneously. This problem has wide applications in discrete manufacturing, especially in chemical and steel casting industries. For the first time, in this study, a 3-indexed mixed-integer linear programming (MILP) model is proposed, which can be efficiently and optimally solved by commercial solvers for small-scale problems. In addition, an improved large neighborhood search (LNS) algorithmic framework with an optimal insertion and tabu-based components (LNSIT) is proposed, which can achieve high-quality solutions for a large-scale FJSPBI in a reasonable time. A perturbation strategy and an optimal insertion strategy are then additionally embedded to improve the exploitation and exploration ability of the algorithm. The proposed model and algorithm are tested on numerous existing benchmark instances without the incompatibility characteristics, and on newly generated instances of the FJSPBI. The experimental results indicate the effectiveness of the proposed MILP model and the algorithm, including the proposed strategies, and the optimal insertion strategy can significantly reduce the computational burden of the LNS algorithm. The comparison results further verify that the proposed LNSIT can directly solve the specific flexible job-shop batch scheduling problem without incompatibility, with better results than existing methods, especially for large-scale instances. Additionally, the impacts of a wide range of characteristics, including batch capacity, incompatibility rate, instance scale, and machine processing rate, on the performance of the LNSIT and the scheduling results are analyzed and presented.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":256165298,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/su15031954","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2071-1050\/15\/3\/1954\/pdf?version=1675059628","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Almost identical polyglutamine-containing proteins with unknown structures have been found in human, mouse and rat genomes (GenBank AJ277365, AF525300, AY879229). We infer that an identical new gene (RING) finger domain of real interest is located in each C-terminal segment. A three-dimensional (3-D) model was generated by remote homology modeling and the functional implications are discussed. The model consists of 65 residues from terminal position 707 to 772 of the human protein with a total length of 796 residues. The 3-D model predicts a ubiquitin-protein ligase (E3) as a binding site for ubiquitin-conjugating enzyme (E2). Both enzymes are part of the ubiquitin pathway to label unwanted proteins for subsequent enzymatic degradation. The molecular contact specificities are suggested for both the substrate recognition and the residues at the possible E2-binding surface. The predicted structure, of a ubiquitin-protein ligase (E3, enzyme class number 184.108.40.206, CATH code 126.96.36.199.4) may contribute to explain the process of ubiquitination. The 3-D model supports the idea of a C3HC4-RING finger with a partially new pattern. The putative E2-binding site is formed by a shallow hydrophobic groove on the surface adjacent to the helix and one zinc finger (L722, C739, P740, P741, R744). Solvent-exposed hydrophobic amino acids lie around both zinc fingers (I717, L722, F738, or P765, L766, V767, V733, P734). The 3-D structure was deposited in the protein databank theoretical model repository (2B9G, RCSB Protein Data Bank, NJ).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30027840,"openaccessinfo":{"externalids":{"MAG":"2104030066","ACL":null,"DOI":"10.1590\/S0100-879X2006005000075","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Children from birth to 14 years of age with American tegumentary leishmaniasis were monitored at the Foundation for Tropical Medicine in the State of Amazonas, Brazil, from January to December 2005; 147 cases were recorded, 55.78% of which were male and 48.3% from the Rio Preto da Eva district. For 90 patients (67.67%), parents or guardians were interviewed about housing in the area where the infection was presumably acquired and the child's habits. Of the group, 58.89% of the children lived in the presumed area of infection, 60% customarily entered the forest with their parents, 91.11% lived in households with domestic animals, 77.78% of the residences were located within 100 meters of the forest; and 76.67% of the patients had at least one relative with a history of American tegumentary leishmaniasis. The transmission pattern was related to activities in the forest around the houses and the living situation near the primary forest, with cases of American tegumentary leishmaniasis found in very young children, suggesting transmission in and around the house, and in a few cases, children entering the forest.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24133145,"openaccessinfo":{"externalids":{"MAG":"2037015643","ACL":null,"DOI":"10.1590\/S0102-311X2007000900029","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sirtuin1 (SIRT1) protein uses NAD+ as a substrate to deacetylate transcription factors, cofactors, and histones to enhance mitochondrial function. We tested the hypothesis whether increased expression of SIRT1 protein in dorsal root ganglion (DRG) neurons would rescue mice from peripheral neuropathy induced by a high fat diet (HFD). Neuron-specific, doxycycline (DOX)-inducible, SIRT1 protein over expressing C57BL6 transgenic mouse (nSIRT1OE Tg) were generated. Expression of SIRT1 protein was observed in small to medium sized DRG neurons. nSIRT1OE was shut off by feeding, weaned Tg mice, with DOX in the diet for 12 weeks. The Tg mice were divided into 3 groups. Group # 1: nSIRT1OE Tg mice fed with standard diet (STD) plus DOX for 4 months; Group # 2: nSIRT1OE Tg mice fed with HFD plus DOX for 4 months; Group # 3: nSIRT1OE Tg mice fed with HFD plus DOX for 2 months until they develop neuropathy and then switched to HFD minus DOX for additional 2 months. Neuropathy was determined by mechanical allodynia thresholds (MAT) and nerve conduction velocity (NCV) at 0, 2 and 4 months. Intraepidermal nerve fiber density (IENFD) was measured at 4 months. MAT, NCV and IENFD were decreased in HFD-fed (Group # 2) mice compared to STD-fed mice (Group # 1) at 2 and 4 months. In Group # 3 mice, 2 months after turning on nSIRT1OE, we observed a reversal of mechanical allodynia, NCV and attenuation of IENFD (Group # 3 compared to Group # 2). Western blot of protein extracts from DRG neurons showed that HFD increased acetylation of proteins and SIRT1OE abolished the HFD-induced acetylation of proteins. The mitochondrial bioenergetics profile of cultured adult DRG neurons showed that hyperglycemia induced a decrease in the spare respiratory capacity in wild type (WT) DRG neurons. This was corrected in nSIRT1OE Tg DRG neurons. In type 2 diabetic neuropathy, altered acetylation of proteins and reduced mitochondrial function via a defective SIRT1 pathway may contribute to developing distal axonopathy. Disclosure K. Chandrasekaran: None. C. Ho: None. M. Salimian: None. P.H. Kumar: None. S. Konduru: None. J.W. Russell: None.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":90672926,"openaccessinfo":{"externalids":{"MAG":"2809395201","ACL":null,"DOI":"10.2337\/db18-57-OR","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Change detection is one of the most important problems in video segmentation. In conventional methods, predetermined thresholds are utilized to test the variation between frames. Although certain reasonings about the thresholds are provided, appropriate determination of these parameters is still problematic. We present a new approach to change detection from an optimization point of view. We model the video frames and the change detection map (CDM) as Markov random fields (MRFs), and formulate change detection into a problem of seeking the optimal configuration of the CDM. Under the MRF assumption, the optimal solution, in the sense of maximum a posteriori (MAP), is obtained by minimizing the energy function associated with the MRF which is designed by utilizing the prior knowledge of noise and contextual constraints on the video frames. An algorithm that computes the potentials and optimizes the solution is constructed by applying the mean field theory (MFT). The experimental results show that the new method detects changes accurately and is robust to noise.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2388448,"openaccessinfo":{"externalids":{"MAG":"2164913004","ACL":null,"DOI":"10.1155\/ASP.2005.1956","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Graduates are a valuable asset for the country as they are the heirs who will continue the development of the country and is \nthe source of human capital. This important resource must be developed through a good education system so as to produce quality and \nknowledgeable human capital for the country. A study was conducted to obtain the true picture of public perception with regard to \nagricultural graduates' competency in Malaysia and what are the factors that influenced the competencies among them. The study was \nconducted in seven public universities and twenty companies in the plantation industry through the distribution of questionnaires to \nthe students of agriculture and interviews with top management in the industry. The results shows that, career opportunities in the \nfarming and commercial agricultural sector in Malaysia is bright and according to the industry, the agricultural graduates in Malaysia \nare competent, however, there are some aspects that need to be improved. Curriculums in universities also play an important role to \nmake sure the students will be competent after graduation with other values inculcated in them during their studies in the University. \nThe majority of these students pursuing agriculture program in the university are of their own initiative and awareness, without \ncoercion from any party. This is a positive finding which goes to shows that, there are still many young people who are interested in \nagriculture. The often heard claims that, agriculture is not a favored field for the youth is not accurate anymore. These students also \nhave the desired characteristics as expected by government to further develop the farming and commercial agricultural sector in \nMalaysia. However the percentage of the students who are willing to venture into the agriculture sector as wage earners or selfemployed after graduation, is still low. The findings of this study have also led to a further study on to two more aspect which are \nperceptions of agriculture students on a career in agriculture and the status of career opportunities in the plantation industry and \ncommercial agriculture in Malaysia","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":15942003,"openaccessinfo":{"externalids":{"MAG":"1513968720","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During lactation, calcium is mobilized from the maternal skeleton to supply the breast for milk production. This results in rapid but fully reversible bone loss. Prior studies have suggested that PTHrP, secreted from the breast, and estrogen deficiency, due to suckling-induced central hypogonadism, combine to trigger bone resorption. To determine whether this combination was sufficient to explain bone loss during lactation, we raised PTHrP levels and decreased levels of estrogens in nulliparous mice. PTHrP was infused via osmotic minipumps and estrogens were decreased either by using leuprolide, a long-acting GnRH agonist, or by surgical ovariectomy (OVX). Bone mineral density declined by 23.2 \u00b1 1.3% in the spine and 16.8 \u00b1 1.9% in the femur over 10 d of lactation. This was accompanied by changes in trabecular architecture and an increase in both osteoblast and osteoclast numbers. OVX and PTHrP infusion both induced a modest decline in bone mineral density over 10 d, but leuprolide treatment did not. The combination of OVX and PTHrP was more effective than either treatment alone, but there was no interaction between PTHrP and leuprolide. None of the treatments reproduced the same degree of bone loss caused by lactation. However, both forms of estrogen deficiency led to an increase in osteoclasts, whereas infusion of PTHrP increased both osteoblasts and osteoclasts. Therefore, although the combination of PTHrP and estrogen deficiency contributes to bone loss, it is insufficient to reproduce the full response of the skeleton to lactation, suggesting that other factors also regulate bone metabolism during this period.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207061980,"openaccessinfo":{"externalids":{"MAG":"2112901782","ACL":null,"DOI":"10.1210\/en.2010-0566","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/endo\/article-pdf\/151\/12\/5591\/9006324\/endo5591.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background Inappropriate antimicrobial use (AMU) is a global concern. Opinions of veterinarians regarding AMU and its role in the development of antimicrobial resistance (AMR) may influence their prescription practices. It is important to understand these opinions, prescription practices and their potential impact on the development of AMR in order to guide efforts to curb the problem. Therefore, the objective of this study was to investigate the antimicrobial prescription practices and opinions of veterinarians in Kentucky regarding AMU and AMR. Methods This cross-sectional study used a 30-question survey questionnaire administered to veterinarians who were members of the Kentucky Veterinary Medical Association. Survey responses from 101 participants were included in the study. Descriptive statistics were computed and associations between categorical variables assessed using Chi-square or Fisher's exact tests. Firth logistic models were used to investigate predictors of \"Compliance with prescription policies\" and \"Cost of antimicrobial affects prescription decisions\". Results Almost all (93%) respondents indicated that improper AMU contributed to selection for AMR. A total of 52% of the respondents believed that antimicrobials were appropriately prescribed, while the remaining 48% believed that antimicrobials were inappropriately prescribed. Significant predictors of compliance with prescription policies were availability of prescription policy at the veterinary facility (Odds Ratio (OR) = 4.2; p<0.001) and over-prescription (OR = 0.35; p = 0.025). Similarly, significant predictors of cost of antimicrobials affecting prescription decisions were lack of post-graduate training (OR = 8.3; p = 0.008) and practice type, with large animal practices having significantly lower odds of the outcome (OR = 0.09; p = 0.004) than small animal practices. Conclusion Most veterinarians indicated that improper AMU contributed to selection for AMR. Since the odds of compliance with prescription policies were 4-times higher among veterinarians working at facilities that had prescription policies compared to those at facilities that didn't, more veterinary facilities should be encouraged to adopt prescription policies to help improve compliance and reduce AMR. Veterinarians would also benefit from continued professional education to help improve prescription practices, antimicrobial stewardship and curb AMR.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":233258514,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pone.0249653","PubMedCentral":"8049335","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0249653&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Reliability and maintainability requirements for reusable space vehicles are more nearly those for an airplane than for a single-use missile or space vehicle. Commercial aircraft philosophies of optimum redundancy, dispatch with components inoperative, in-flight fault isolation, and on-condition maintenance, and the considerations necessary in applying them to reusable space vehicles are presented. A reliability and maintainability design philosophy for reusable space vehicles is developed, based on trade-offs that are a function of the vehicle mission parameters.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4677769,"openaccessinfo":{"externalids":{"MAG":"2588614707","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"I was initially quite puzzled when I received this book. It appeared to be totally irrelevant to a European, since we hardly have any ''wildlands,'' and the subtitle, ''Pioneering Approaches to Science and Management,'' appeared self-contradictory, as true wildlands are not managed. So what might this be? My skepticism vanished quickly when I realized that the book is about the management of rural areas and reserves in the face of climate change. As such, I think it is a landmark volume that pulls together many highly useful insights from a long-term project, the ''Landscape Climate Change Vulnerability Project'' (LCCVP), and 2 of its key case studies, the Great Northern ''Landscape Conservation Cooperative'' (LCC) and the Appalachian LCC. Readers first have to acquaint themselves with these (and other) relatively cumbersome terms and acronyms that are used throughout the book. One gets used to them. The book features 17 chapters written by different groups of authors and is structured into 4 major parts. It starts off with a chapter on the rationale behind studying climate change in ''wildlands,'' providing the background of the LCCVP project and presenting an overview of the 2 case studies as well as the book as a whole. The first major part of the book consists of 2 chapters. First, it provides the theoretical framework for climate change adaptation studies, with a very accessible explanation of the adaptation framework as well as the concept of vulnerability according to the Intergovernmental Panel on Climate Change (IPCC). Second, it provides a highly interesting and comprehensive account of the stumbling blocks that need to be overcome when attempting to integrate science into management. This is not a theoretical consideration but clearly derives from (difficult) experiences in the context of the project upon which this book focuses. The second major part of the book deals with climate and land use changes as important driving forces of ecosystem change. It partly looks back into the deep past (paleoecology) but does so to highly different degrees for the 2 case studies. This is a general feature (or problem?) of the book: some chapters are set up as twins to evaluate the 2 case studies; some chapters deal with both case studies in an integrated way; and some chapters refer to them only tangentially. This is at times confusing, but probably it simply reflects the depth of the available material and expertise in the consortium. The third part presents studies investigating ecological consequences and vulnerabilities, strongly relying on various types of species distribution models. It is the sequence of these 6 chapters\u2014which constitute the bulk of the book\u2014that I found most confusing. The first was clearly distinct, focusing on hydrology and carbon relations. The following 4 chapters, however, appeared to be partly redundant because they treat very similar subjects and are not consistently labeled: the distinction between the focus on ''tree species,'' ''vegetation (communities),'' ''national parks,'' and ''biome types'' is not fully matched by the contents of the respective chapters. However, all chapters are carefully written and provide much useful information, including a good consideration of uncertainties. The section concludes with a highly specific case, salmonid fish, looking at both case studies. Two hundred and fifty-eight pages into the volume, management has been touched upon only lightly. Fortunately, the final 4 chapters deal with the management implications of all the information to which readers have been exposed. The first chapter of this last section provides the theoretical background by very systematically explaining the framework for identifying climate adaptation options, based on a range of concepts from the literature. An important notion arising from the book is that, even in the absence of any formal framework for the identification of adaptation options, true climate adaptation may be achieved\u2014although a clear framework will certainly help to ease the process. The following 3 chapters focus on Rocky Mountain National Park and the Greater Yellowstone Ecosystem in the United States, albeit at different levels of organization. One chapter emphasizes adaptive management in Rocky Mountain National Park as an administrative unit: it presents a unique account of the challenges and hurdles to be overcome at the interface between science and public perception of the land, where adaptive management practices sometimes contradict common sense and need to be carefully explained to the public. Another chapter offers a case study of a single species, whitebark pine, and can be viewed as a model example of how to deal with an emblematic species that has become highly endangered because of several coacting factors\u2014a template to consider when focusing on other species. Last, there is a chapter on the success of management practices in the Greater Yellowstone Ecosystem. These chapters are highly informative and well written, although it is a true pity that the Appalachian LCC is entirely absent. Mountain Research and Development (MRD) An international, peer-reviewed open access journal published by the International Mountain Society (IMS) www.mrd-journal.org MountainMedia","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":133965949,"openaccessinfo":{"externalids":{"MAG":"2800976626","ACL":null,"DOI":"10.1659\/mrd.mm219","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/bioone.org\/journals\/Mountain-Research-and-Development\/volume-38\/issue-1\/mrd.mm219\/Climate-Change-in-Wildlands--Pioneering-Approaches-to-Science-and\/10.1659\/mrd.mm219.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Brownian dynamics simulations of single-patch Janus particles under sedimentation equilibrium reveal that the phases found at fixed temperature and volume fraction are extremely sensitive to small changes in lateral box dimension. We trace this sensitivity to an uncontrolled parameter, namely, the pressure component parallel to the hexagonally ordered layers formed through sedimentation. We employ a flexible-cell constant-pressure scheme to achieve explicit control over this usually overlooked parameter, enabling the estimation of phase behavior under given pressure anisotropy. Our results show an increase in the stability range of an orientationally ordered lamellar phase with lateral layer compression and suggest a novel mechanism to control solid-solid phase transitions with negligible change in system volume, thus showing prospect for design of novel structures and switchable crystals from anisotropic building blocks.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":205224485,"openaccessinfo":{"externalids":{"MAG":"2747734926","ACL":null,"DOI":"10.1063\/1.4997784","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"T he dissertation process begins with the development of a proposal that sets forth both the exact nature of the matter to be investigated and a detailed account of the methods to be employed. In addition, the proposal usually contains material supporting the importance of the topic selected and the appropriateness of the research methods to be employed. A proposal may function in at least three ways: as a means of communication , as a plan, and as a contract. Communication The proposal serves to communicate the investigator's research plans to those who provide consultation, give consent, or disburse funds. The document is the primary resource on which the graduate student's thesis or dissertation committee must base the functions of review, consultation, and, more important, approval for implementation of the research project. It also serves a similar function for persons holding the purse strings of foundations or governmental funding agencies. The quality of assistance, the economy of consultation, and the probability of financial support will all depend directly on the clarity and thoroughness of the proposal.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":50756607,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND Colorectal laterally spreading tumors (LSTs) with malignant potential require en bloc resection by endoscopic submucosal dissection (ESD), but lesions with deep submucosal invasion (SMI) are endoscopically unresectable. AIM To investigate the factors associated with high-grade dysplasia (HGD)\/carcinoma and deep SMI in colorectal LSTs. METHODS The endoscopic and histological results of consecutive patients who underwent ESD for colorectal LSTs in our hospital from June 2013 to March 2019 were retrospectively analyzed. The characteristics of LST subtypes were compared. Risk factors for HGD\/carcinoma and deep SMI (invasion depth \u2265 1000 \u03bcm) were determined using multivariate logistic regression. RESULTS A total of 323 patients with 341 colorectal LSTs were enrolled. Among the four subtypes, non-granular pseudodepressed (NG-PD) LSTs (85.5%) had the highest rate of HGD\/carcinoma, followed by the granular nodular mixed (G-NM) (77.0%), granular homogenous (29.5%), and non-granular flat elevated (24.2%) subtypes. Deep SMI occurred commonly in NG-PD LSTs (12.9%). In the adjusted multivariate analysis, NG-PD [odds ratio (OR) = 16.8, P < 0.001) and G-NM (OR = 7.8, P < 0.001) subtypes, size \u2265 2 cm (OR = 2.2, P = 0.005), and positive non-lifting sign (OR = 3.3, P = 0.024) were independently associated with HGD\/carcinoma. The NG-PD subtype (OR = 13.3, P < 0.001) and rectosigmoid location (OR = 8.7, P = 0.007) were independent risk factors for deep SMI. CONCLUSION Because of their increased risk for malignancy, it is highly recommended that NG-PD and G-NM LSTs are removed en bloc through ESD. Given their substantial risk for deep SMI, surgery needs to be considered for NG-PD LSTs located in the rectosigmoid, especially those with positive non-lifting signs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225807358,"openaccessinfo":{"externalids":{"MAG":"3034159150","ACL":null,"DOI":"10.4251\/wjgo.v14.i7.1337","PubMedCentral":"9305571","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9305571","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Using the method of Fourier transform, cryo-electron micrographs of two types of archaeal feast\/famine regulatory proteins (FFRPs), pot0434017 (FL11) and pot1216151 (DM1), were analyzed. After correcting the Fourier power spectra by considering effects of the contrast transfer functions (CTFs), peaks were identified at frequencies, corresponding to the particle size of ~130 \u00c5 for FL11 in the complex with DNA, in addition, a smaller size, ~40 \u00c5, for the same protein in the absence of DNA, the particle size of ~65 \u00c5 for DM1 when interacting with a ligand, and a smaller size of ~30 \u00c5 when the ligand was removed. These numbers are consistent with our previous observations that dimers of FL11 form octamers, i.e. tetrameric assemblies of the dimers, upon intercation with DNA, and that similar octamers of a smaller FFRP, DM1 of the molecular weight approximately half that of FL11, are stabilized by interaction with the ligand. Some aspects of CTF correction are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235240703,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":"8143867","ArXiv":null},"license":"CCBY","url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mutants of Salmonella typhimurium were isolated that require tyrosine for growth because of an altered tyrosyl-transfer ribonucleic acid (tRNA) synthetase. Extracts of one strain (JK10) contain a labile enzyme with decreased ability to transfer tyrosine to tRNATyr and a higher Km for tyrosine than the wild-type enzyme. Strain JK10 maintains repressed levels of the tyrosine biosynthetic enzymes when the growth rate is restricted due to limitation of charged tRNATyr. Several second-site revertants of strain JK10 exhibit temperature-sensitive growth due to partially repaired, heat-labile tyrosyl-tRNA synthetase. The tyrosine biosynthetic enzymes are not derepressed in thermosensitive strains grown at the restrictive temperature. A class of tyrosine regulatory mutants, designated tyrR, contains normal levels of tyrosyl-tRNA synthetase and tRNATyr. These results suggest that charging of tRNATyr is not necessary for repression. This conclusion is substantiated by the finding that 4-aminophenylalanine, a tyrosine analogue which causes repression of the tyrosine biosynthetic enzymes, is not attached to tRNATyr in vivo, nor does it inhibit the attachment reaction in vitro. A combined regulatory effect due to the simultaneous presence of tyrS and tyrR mutations in the same strain was detected. The possibility of direct participation of tyrosyl-tRNA synthetase in tyrosine regulation is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43745563,"openaccessinfo":{"externalids":{"MAG":"1942554446","ACL":null,"DOI":"10.1128\/jb.112.3.1254-1263.1972","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jb.asm.org\/content\/jb\/112\/3\/1254.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The concept of learning gains has had a wider coverage internationally but is fairly new to the UK (HEFCE 2015).This session introduces learning gains (LGS) in the context of HE and compares these to learning outcomes and value-added. It critically evaluates methods for measuring LGS and will focus on student e-portfolios and reflective accounts as evidence of PPD and LGS. We introduce the wider spectrum of learning opportunities within Bournemouth University (BU), including extra-curriculum activities such as the university Global Talent programme, the staff-student collaboration competitions, SUBU clubs and societies, and the Student Project Bank as hubs for social and experiential learning. We analyse these and synthesise the findings into the precepts of a strategy for maximizing learning gains. It is illustrated through the lived experiences of a BU student, who talks about his journey as undergraduate Business School student who demonstrates how classes have inspired his business visions and further engagement with experiential and social learning through co-curriculum and extra-curriculum activities. We present elements of his e-portfolios and other artifacts evidencing his PPD attainment. Building on student and academic reflections, we discuss opportunities for collaboration in an international study on LGS and employability. Our conclusion focuses on the appreciation of how personalisation of education could be achieved through linking course studies with extra-curriculum activities, thus fusing formal, social and experiential learning, as we as on the role of reflective accounts and e-portfolios as evidence of learning gains and student employability.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":199812000,"openaccessinfo":{"externalids":{"MAG":"2963426960","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Prior studies have unveiled the vulnerability of the deep neural networks in the context of adversarial machine learning, leading to great recent attention into this area. One interesting question that has yet to be fully explored is the bias-variance relationship of adversarial machine learning, which can potentially provide deeper insights into this behaviour. The notion of bias and variance is one of the main approaches to analyze and evaluate the generalization and reliability of a machine learning model. Although it has been extensively used in other machine learning models, it is not well explored in the field of deep learning and it is even less explored in the area of adversarial machine learning. \nIn this study, we investigate the effect of adversarial machine learning on the bias and variance of a trained deep neural network and analyze how adversarial perturbations can affect the generalization of a network. We derive the bias-variance trade-off for both classification and regression applications based on two main loss functions: (i) mean squared error (MSE), and (ii) cross-entropy. Furthermore, we perform quantitative analysis with both simulated and real data to empirically evaluate consistency with the derived bias-variance tradeoffs. Our analysis sheds light on why the deep neural networks have poor performance under adversarial perturbation from a bias-variance point of view and how this type of perturbation would change the performance of a network. Moreover, given these new theoretical findings, we introduce a new adversarial machine learning algorithm with lower computational complexity than well-known adversarial machine learning strategies (e.g., PGD) while providing a high success rate in fooling deep neural networks in lower perturbation magnitudes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":220936065,"openaccessinfo":{"externalids":{"MAG":"3046756155","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2008.00138"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"NEURILEMOMAS (benign schwannomas) are found in 1.5%1to 18%2,3of patients with von Recklinghausen's neurofibromatosis and make up 1% of orbital tumors.4-9They rarely, if ever, undergo malignant change.2,10-17 This paper describes, to this author's knowledge, the first reported case of sarcomatous transformation of a benign neurilemoma of the orbit. Report of a Case A 27-year-old white woman (51-38-29) was first seen at the University of Illinois Eye Clinic on Nov 21, 1966, and was admitted to the hospital with a six-week history of a mass in the superior right orbit. Two weeks previous to admission she noted gradual proptosis and some pain. Additional history revealed the mother and sister had cafe-au-lait spots. Examination of the patient showed a right superior orbital mass with some proptosis and mechanical limitation of upward gaze. The mass was firm, discrete, round, and movable. Vision was 20\/40 OD, 20\/30 OS.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":45777818,"openaccessinfo":{"externalids":{"MAG":"2001122201","ACL":null,"DOI":"10.1001\/ARCHOPHT.1971.01000010270006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This Master Thesis was conducted by Rikard Eriksson and Vlad Badea for their Master of Science degree in Electronics Design Engineering at the University of Linkoping (Linkopings Universitet), Sweden. HTC Sweden AB initialized this Thesis and the Thesis contains a pre study of pseudolite based indoor navigation systems, a design of a simple pseudolite and finally some recommendations of applications.The pre study starts off with an introduction of the GPS system. This since pseudolite based systems and GPS have many similarities. Different pseudolites based techniques were then investigated and the pre study is wrapped up with a very short briefing on the Hammerhead chip.Some of the pseudolite based techniques were worth some more looking into and a pseudolite was therefore designed and simulated. There was unfortunate not enough time to actually build the pseudolite and verify it.Some recommendations to HTC Sweden were given in the last chapter of this thesis. The authors of this thesis recommend some interesting techniques and how the future work could proceed.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":108013555,"openaccessinfo":{"externalids":{"MAG":"41187118","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This case study explores the opportunities for students of Industrial Design Engineering to engage with direct and indirect stakeholders by making their design process and results into open-ended designed solutions. The reported case study involved 47 students during a two-weeks intensive course on the topic of urban gardening. Observations were collected during three distinctive phases: the co-design phase, the creation of an open design, and the sharing of these design solutions on the online platform Instructables.com. The open sharing of local solutions triggered more global discussions, based on several types of feedback: from simple questions to reference to existing works and from suggestions to critiques. Also, some examples of re-appropriation of the designed solutions were reported. These feedbacks show the possibilities for students to have a global vision on their local solutions, confronting them with a wider and more diverse audience. The case study shows, on the other hand, the difficulty in keeping students engaged in this global discussion, considering how after a few weeks the online discussions dropped to an almost complete silence. It is also very difficult with such online platforms to follow the re-appropriation cycles, losing the possibility of exploring the new local context where the replication\/modification of the designed product occurred. The course's focus on open design is interesting from both the design and educational points of view. It implies a deep change in the teaching approach and learning attitude of students, allowing unknown peers to take part in the design process and fostering a global discussion starting from unique and local solutions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":64266869,"openaccessinfo":{"externalids":{"MAG":"2461006872","ACL":null,"DOI":"10.19173\/IRRODL.V17I4.2543","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mixedwood forests are an ecologically and economically important forest type in central Canada, but the ecology of these forests is not as well studied as that of single\u2010species dominated stands in the boreal forest. Northern boreal mixedwood forests have only recently been harvested and the effects of harvesting on carbon content in these stands are unknown. We quantified the carbon content and aboveground net primary production (NPP) for four different\u2010aged mixedwood boreal forest stands in northern Manitoba, Canada. The stands included 11\u2010, 18\u2010, and 30\u2010year\u2010old stands that originated from harvesting and a 65\u2010year\u2010old fire\u2010originated stand that typifies the origin of all northern boreal mixed\u2010wood forests that are coming under management. Trees included black spruce (Picea mariana (Mill.) B.S.P.), jack pine (Pinus banksiana Lamb.), balsam poplar (Populus balsamifera L.), and quaking aspen (Populus tremuloides Michx.). Overstory biomass was estimated using species\u2010specific allometric models that generally explained greater than 95% of the observed variation in biomass. Carbon content of the overstory vegetation was greatest in the 65\u2010year\u2010old stand and was 74% larger than the 11\u2010year\u2010old stand and showed a positive relationship with stand age (F1,\u20032=122.62, P=0.0081 R2=0.99). The slope of mineral soil carbon did not differ significantly among stands (F1,\u20032=0.39, P=0.5956, R2=0.16). Coarse woody debris carbon content followed a U\u2010shaped pattern among stands. Aboveground NPP differed by 24% between the youngest and oldest stand. Mean annual carbon accumulation and aboveground NPP rates of the mixedwood forests were on average two times greater than nearby relatively pure stands studied during the BOREAS (BOReal Ecosystem Atmospheric Study) project. The trends in the results, along with other field studies, suggest that harvesting does not significantly affect the total soil carbon content. The results of this study suggest that scientists should be cautious about extrapolating results from BOREAS stands to a broader region until more data on other forest types and regions are available.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":84557584,"openaccessinfo":{"externalids":{"MAG":"2024473795","ACL":null,"DOI":"10.1111\/j.1365-2486.2005.01019.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Magnesium is a light metal with a relatively low cost. It can form magnesium hydride (MgH2), which is interesting for the safe storage of hydrogen in the solid state, thanks to its high gravimetric capacity of 7.6%. The Mg application is hampered by its high H2 absorption\/desorption temperature and slow kinetics. The High energy ball milling (HEBM) has been successful in preparing Mg-based nanocomposites, resulting in rapid kinetics around 300 \u00b0C. However, powder contamination, process time and the need for inert atmosphere to its manipulation are limiting the HEBM. In order to improve its performance, Mg, with or without iron addition, was submitted to two main processing routes. First the HEBM was performed as a reference for the milled powder. In another route, bulk Mg was processed as stacked plates, and also, Fe was added in the form of continuous and fragmented wires, or powdered. In this route, Mg was submitted to severe plastic deformation (SPD) at room temperature, starting with the extensive cold rolling (ECR) and followed by the repetitive cold rolling (ARB). The materials were characterized by X-ray diffraction (XRD), optical microscopy (OM), scanning (SEM) and transmission electron microscopy (TEM). The H2 storage properties were evaluated by differential scanning calorimetry (DSC) and the Sievert's volumetric method. The Mg submitted to HEBM was superior in the activation, kinetics and H2 storage capacity, compared to the ECR+ARB. The Mg with Fe addition, milled for 10 h, showed optimum kinetics and a large reduction on the desorption temperature. However, the Mg processed by ECR+ARB with Fe addition under varied morphologies, yield a high level of accumulated deformations and defects, permanence of the (002) plane texture and submicrometric grain refinement, reflecting in good activation and high H2 storage capacity, which still requires more studies to overcome the better results of the HEBM.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":104020905,"openaccessinfo":{"externalids":{"MAG":"2795998336","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"If African American boys are contemplating taking their lives at early ages, the hope for future generations is challenging at best. What is going on in African American communities that there is a lack of safe spaces for boys to express their emotions and to share their travails with supportive networks in lieu of ending their lives? The situation of African American boys (ages 5-11) committing suicide at higher levels-more than any other group-and the recent studies regarding the rising rates of suicide among African American adolescent boys (12 and older) call for greater reflection and more discourse around the mental health challenges faced by this group. We must identify the emotional and psychological reasons that underlie suicidal behaviors for African American boys and work to provide immediate intervention. Families, educators, and community workers play key roles in identifying signs of mental health challenges such as depression and connecting African American boys to mental health care services. In this article, the authors discuss specific ways to better support boys who exhibit early signs of depression and suicidal behavior. Topics discussed include (1) untreated depression among African American youth; (2) looking deeper at the reasons for untreated depression; (3) misunderstanding and denial of mental health challenges; (4) risk factors in schools; (5) harsh discipline practices; (6) low teacher expectations; and (7) disconnection from adults. (PsycINFO Database Record","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":4645251,"openaccessinfo":{"externalids":{"MAG":"2736234899","ACL":null,"DOI":"10.1037\/ort0000198","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The thermal structure of a coronal loop, both along and across the loop, is vital in determining the exact plasma heating mechanism. High-resolution spectroscopic observations of the off-limb corona were made using the 25 cm Norikura coronagraph, located at Norikura, Japan. Observations on a number of days were made simultaneously in four forbidden iron emission lines, namely, the [Fe\u2009xi] 7892\u2009\u00c5 line, the [Fe\u2009xiii] 10747\u2009\u00c5 and 10798\u2009\u00c5 lines, and the [Fe\u2009xiv] 5303\u2009\u00c5 line and on some days made only in the [Fe\u2009xi] 7892\u2009\u00c5 and [Fe\u2009x] 6374\u2009\u00c5 lines. Using temperature sensitive emission line ratios [Fe\u2009xiv] 5303\u2009\u00c5\/[Fe\u2009xiii] 10747\u2009\u00c5 and [Fe\u2009xi] 7892\u2009\u00c5\/[Fe\u2009x] 6374\u2009\u00c5, we compute the electron temperatures along 18 different loop structures observed on different days. We find a significant negative temperature gradient in all of the structures observed in Fe\u2009xiv and Fe\u2009xiii and a positive temperature gradient in the structures observed in Fe\u2009xi and Fe\u2009x. Combining these results with the previous investigations by Singh and his collaborators, we infer that the loop tops, in general, appear hotter when observed in colder lines and colder when observed in relatively hotter lines as compared to their coronal foot points. We suggest that this contrasting trend observed in the temperature variation along the loop structures can be explained by a gradual interaction of different temperature plasma. The exact mechanism responsible for this interaction must be investigated further and has the potential to constrain loop heating models.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":118362679,"openaccessinfo":{"externalids":{"MAG":"2052525029","ACL":null,"DOI":"10.1088\/2041-8205\/765\/2\/L46","PubMedCentral":null,"ArXiv":"1302.5905"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"S N O W M A S S , C O L O. \u2014 Serious questions exist about the safety and efficacy of the popular practice of high-dose vitamin D supplementation across a broad swath of the population. One of these concerns is that not all of the extra calcium absorption promoted by boosting vitamin D is going into bone to prevent fractures. Some of it may actually be taken up by atherosclerotic plaque, increasing the risk of cardiovascular events, Dr. Lenore M. Buckley cautioned at a symposium sponsored by the American College of Rheumatology, This is of particular concern in patients with known coronary disease and for those at high risk, including individuals with rheumatoid arthritis, systemic lupus erythematosus, diabetes, or psoriasis, added Dr. Buckley, professor of medicine at Virginia Commonwealth University, Richmond. Discussing findings from a recent cross-sectional study involving 340 African Americans with type 2 diabetes, Dr. Buckley said that serum 25-hydroxyvitamin D levels were positively associated with increased calcified atherosclerotic plaque in the aorta and carotid arteries ( J. Clin. Endo. Metab. Jan. 8, 2010; Epub ahead of print PMID:20061416). \"The effects of supplementing vitamin D to raise the serum 25-hydroxyvitamin D level on atherosclerosis in African Americans are unknown. Prospective trials are needed,\" the investigators wrote. Recently, a large prospective randomized trial assessed the effects of using calcium supplements on vascular event rates, but it did not involve African Americans. The trial involved 1,471 healthy postmenopausal New Zealand women who were randomized to receive either supplemental calcium or placebo. By 5 years of follow-up, there were a total of 101 myocardial infarctions, strokes, and sudden deaths in 69 women in the supplemental calcium group compared to 54 such events in 42 control subjects (Br. Med. J. 2008; 336:262-6). The numbers needed to treat (NNT) were \"particularly disturbing,\" said Dr. Buckley. The NNT for 5 years of supplemental calcium to cause one additional MI than with placebo was 44. The NNT for one stroke was 56. And the NNT to cause one additional cardiovascular event was 29. In contrast, the NNT to prevent one symptomatic fracture was 50. The vascular event rate was higher in women with high compliance with calcium supplementation. The event rate was also higher during months 30-60 of follow-up, consistent with an initial latent period in which silent vascular damage occurs in advance of climbing cardiovascular event rates. The vitamin D assay has become one of the most-ordered U.S. lab tests, despite the assay's questionable reliability, its $40-$200 cost, and considerable unresolved debate as to what constitutes an optimal blood level. Medicare is considering changing policy such that vitamin D tests for screening purposes would not be covered, according to Dr. Buckley. There is solid evidence that vitamin D supplementation reduces fracture risk in the elderly, especially in those with low serum levels. But that's not what's driving the astounding recent growth in serum vitamin D screening and supplementation. The impetus for the upsurge in screening is the hope that it might protect against a broad range of chronic diseases, including cancers, dementia, autoimmune diseases, and cardiovascular disease. The trouble is, that hope is driven mostly by epidemiologic data, which must be viewed as hypothesis-generating rather than definitive. The classic example of how misleading epidemiologic associations can be is the expectation that estrogen replacement would reduce cardiovascular risk in postmenopausal women; when the Women's Health Initiative and other prospective trials were eventually carried out, it turned out just the opposite was true, Dr. Buckley noted. \"The question we have to ask is: What does that low serum vitamin D level mean? Is it the thing that predisposes, or is it somehow a byproduct of illness?\" she continued. There is intriguing evidence to indicate the optimal level of vitamin D to promote bone health, muscle strength, immunity, and other key functions may vary by race. Data from the National Health and Nutrition Examination Survey show that very few white children ages 1-12 years are vitamin D\u2013deficient using the classic threshold of 15 ng\/mL. In contrast, about 10% of non-Hispanic black 1to 6-year-olds are vitamin D\u2013deficient, as are close to 30% in the 7-12 age bracket (Pediatrics Sept. 2009; e362-70; doi:10-1542\/peds.2009-0051). Many observers see this racial disparity as a public health problem reflecting unequal access to services. But there is a conundrum here: If vitamin D deficiency is rampant in black children, why do they have greater bone strength and muscle mass than whites? \"It makes one wonder whether the definition of normal levels should vary by race,\" according to the rheumatologist. Support for this notion comes from studies showing that pushing serum vitamin D levels to 30 ng\/mL or higher in whites reduces their parathyroid hormone levels, while pushing levels above 20 ng\/mL in African Americans\u2014young or old\u2014does not further decrease parathyroid hormone or increase bone density. In her own practice, Dr. Buckley generally tries to get patients into the 20to 29-ng\/mL range, while in African Americans and patients with known cardiovascular disease she aims for 15 ng\/mL or slightly more, she said. She reserves expedited supplementation\u201450,000 IU weekly for 8 weeks\u2014mainly for vitamin D\u2013deficient elderly patients at high risk for fracture or fall. That's where there is supporting evidence of benefit. There is no evidence to support supplementation in young or middle-aged patients. Like many others, Dr. Buckley eagerly awaits fresh guidance in the form of updated recommendations on vitamin D from the Institute of Medicine. That IOM report, due this spring, is expected to recommend an increase in the currently recommended supplemental 400 IU\/day for 50to 70-year-olds not getting sufficient vitamin D from the sun (see related article on p. 1). Her hope is the IOM will address the thorny issues of who should receive supplementation, and how fast it should be done. Dr. Buckley reported having no relevant financial relationships. \u25a0","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":67935513,"openaccessinfo":{"externalids":{"MAG":"4467888","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study of AGB stars necessarily covers a wide range of topics, from the primary astronomical observations to their interpretation in terms of fundamental physics. All that requires proper ad hoc methodologies, among which numerical modeling of the outer layers of AGB stars plays a paramount role. In this paper, we present an iterative sequential procedure, operative and physically sound, tailored to compute extended stellar atmospheres. It will constitute the backbone of the in fieri TEIDE package to be implemented into our VULCAN code. Such an improvement will allow us to compute more realistic models of the extended atmospheres of AGB stars taking into account important physical aspects that are neglected in the actual version of VULCAN.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":239659579,"openaccessinfo":{"externalids":{"MAG":"3198624203","ACL":null,"DOI":"10.3390\/universe7090340","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2218-1997\/7\/9\/340\/pdf?version=1631246402","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A technique for performing Monte-Carlo simulation using an Excel spreadsheet has been developed. This technique utilizes the powerful mathematical and statistical capabilities of Excel. The functional reliability block diagram (RBD) of the system under investigation is first transformed into a table in an Excel spreadsheet. Each cell within the table corresponds to a specific block in the RBD. Formulae for failure times entered into these cells are in accordance with the failure time distribution of the corresponding block and can follow exponential, normal, lognormal or Weibull distribution. The Excel pseudo random number generator is used to simulate failure times of individual units or modules in the system. Logical expressions are then used to determine system success or failure. Excel's macro feature enables repetition of the scenario thousands of times while automatically recording the failure data. Excel's graphical capabilities are later used for plotting the failure probability density function (PDF) and cumulative distribution function (CDF) of the overall system. The paper discusses the results obtainable from this method such as reliability estimate, mean and variance of failures and confidence intervals. Simulation time is dependent on the complexity of the system, computer speed, and the accuracy desired, and may range from a few minutes to a few hours.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":61951929,"openaccessinfo":{"externalids":{"MAG":"2165030400","ACL":null,"DOI":"10.1109\/RAMS.2000.816305","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With the emerging concepts of internet of things (IoT), bring your own device (BYOD), smart homes, vehicular adhoc networks 9VANETS), mobility and new service demands, legacy networking approaches are being considered complex and inefficient. In recent past a new approach called software defined networks (SDN) has emerged to revolutionize the four decades old networking approaches. The SDN's capacity to programmatically control and modify the network behavior has given extra edge to its wide scale proliferation. After some large scale successful deployments by Google, VMware, Facebook etc., SDN has attained huge research and vendor attention. Almost all large scale national research and education networks (NRENs) have prepared Opne flow based SDN test beds for collaborative future networking research.Pakistan education Research Network (PERN) project is still lagging behind in utilizing its network infrastructure for research and experimentation purpose. Although, green filed network migration of PERN is a challenging task and requires lot of budget and technical expertise, transitional approaches are the best way to migrate from legacy networking to SDN. This study highlights the role of SDN and its deployments in educational research networks for next generation network experimentation. This study proposes transitional approaches for the migration of PERN towards OpenFlow based SDN environment. In this study, it will also discuss how SDN based PERN can facilitate IT, telecommunications, software engineering, computer scientist and network engineering researchers in conducting future network experimentation.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":63477573,"openaccessinfo":{"externalids":{"MAG":"2552753664","ACL":null,"DOI":"10.3923\/ITJ.2016.137.143","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this article, the Author analyses the Bradleian concept of contradiction and the thesis herewith proposed consists in thinking that the so-called \u00abRussell's antinomy\u00bb, one of the most popular and most discussed theoretical points in the modern and contemporary philosophy, is rooted or better is implied in Bradley's system. The Author argues that, formulating and presenting it at Frege, Russell articulated a question opening a consequent philosophic perspective already conceptually implied by Bradley's theory of relations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":170332907,"openaccessinfo":{"externalids":{"MAG":"2217322733","ACL":null,"DOI":"10.13130\/2039-9251\/6654","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim: To assess limitation of vital activities in disabled asthma patients. Methods: A retrospective analysis of 64 disabled patients9 with asthma III and IV st. was performed (age 46,1\u00b11,1 yrs, 23 male). 81% patients had uncontrolled asthma, ACT 21,4\u00b10,7 pts, 89.4% received ICS. Were assessed abilities of movement, self-service, behavior control, communication, education and work capacity. Results: Among life activities mostly were limited movement (80%), ability to work (100%), education (66,7%), communication (44%), and self-service (44%). Movement ability was correlated with comorbidity index (CI) (R=0,41), forced vital lung capacity (R=-0,36), FEV1 (R=-0,39), size of left atrium of heart (R=0,36), ejection fraction of left ventricle (R=-0,40), end-diastolic dimension of right ventricle (R=0,33). Education ability was connected to FVC (R=-0,41) cognitive impairment (R=0,31) and attention level (R=-0,69). Communication ability correlated with CI (R=0,42), FEV1 (R=-0,35), size of left atrium of heart (R=0,38), end-diastolic dimension of left ventricle (R=0,45), end-diastolic dimension of right ventricle (R=0,54). Self-service limitation correlated with CI (R=0,42), FVC (R=-0,41), FEV1 (R=-0,42), size of left atrium of heart (R=0,37), ejection fraction of left ventricle (R=-0,31), end-diastolic dimension of right ventricle (R=0,51) and attention level (R=0,76). All the correlations were significant with p","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78668545,"openaccessinfo":{"externalids":{"MAG":"2515274139","ACL":null,"DOI":"10.1183\/13993003.congress-2015.PA5015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This web-based system is developed on behalf of the awareness on the importance of IT (Information Technology) usage in medical field. The latest\nissue about information system in medical field are the Information System in Strategic Plan (ISSP), Computerized Information system in health management\nElectronic Medical Record (EMR) and tele-medical. The Decision support System for the choosing of herbal medication for catarrn disease is an on-line\nbased decision support system. This proposed system intend to help users in retrieving information and helping them to choose suitable herbal medicine for\ntheir disease. This system, are capable to analyze appropriate herbal treatment for specify medical purpose based on several criteria. This system which use\nevolution prototype approach will be developed using Microsoft Windows XP operating systems, Macromedia Dreamweaver MX user interface, MS SQL\nServer 2000 database and ASP as Dynamic HTML.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110971197,"openaccessinfo":{"externalids":{"MAG":"2224135490","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Modified high-density polyethylene (m-HDPE) is a candidate for high-voltage solid DC cable insulation. Based on the space-charge measurements on thick modified HDPE samples (1.5 mm), it was reported that modified HDPE contained relatively small amount of space charge and showed high breakdown strength. We measured space-charge distribution in thin m-HDPE samples (50 \/spl mu\/m) by using the laser-induced-pressure-pulse method in order to clarify effects of charge injection on the space-charge characteristics and electrical conduction. The samples with Au electrodes showed positive home space charge at room temperature but negative charge became dominant at higher temperature. These charges are due to injection from the electrode. The space-charge behaviour at voltage polarity reversal suggested that these space charges affected the breakdown characteristics. The samples with a semiconducting layer showed space-charge and conduction characteristics different from those with metal electrodes. The change was partly attributed to the diffusion of impurities during the hot-press process for applying the semiconducting layer.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110048061,"openaccessinfo":{"externalids":{"MAG":"2129515041","ACL":null,"DOI":"10.1109\/ISEIM.1998.741801","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper carried out experimental studies on the influence of vertical heterogeneity of reservoir on the steam drive effect after multiple-round steam stimulations. Taking the actual productive process of a heavy oil reservoir as an example, a physical model for the vertical heterogeneity was established. First, under the initial reservoir conditions, conduct multiple rounds of steam stimulations to obtain the initial reservoir conditions of steam drive, and then carry out physical simulation of steam drive, including the simulation of the horizontal reservoir and the tilted one. The development of temperature field and the oil-water output changes indicate that when the steam drive is conducted after the steam stimulations, the steam advances along the high permeability layer with better steam stimulation effect, once it gets a breakthrough, the swept volume will not change. For the tilted reservoir, due to the beneficial effects of the gravity drainage, its displacement effect is better than the horizontal one, which provides an important basis for the adjustment of layers and the section of methods of gas injection when the steam simulation is converted into steam drive.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":12389000,"openaccessinfo":{"externalids":{"MAG":"2236166306","ACL":null,"DOI":"10.2174\/1874834101508010415","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/openpetroleumengineeringjournal.com\/VOLUME\/8\/PAGE\/415\/PDF\/","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Retaining a reserve of buds or meristems for recovery from I occasional damage is widespread among plants. Yet possession of a bud bank is not ubiquitous. Presumably there are costs to maintaining buds and for some species these costs outweigh the benefits. This paper has two themes. We estimate carbon costs of constructing and maintaining buds, and review other costs and benefits of buds in different situations. Second, we develop a framework for thinking quantitatively about the costs and benefits. Given available data and some reasonable assumptions, the absolute carbon costs of buds seem small. So the fact that many species do not maintain bud banks suggests that the benefits of buds may be negligible for them. Alternatively, buds may carry other costs. Costs of bud protection or of reserves that are coordinated with buds seem likely candidates.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":84352472,"openaccessinfo":{"externalids":{"MAG":"2013211299","ACL":null,"DOI":"10.1111\/J.0030-1299.2004.13204.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chronotropic and inotropic actions of phencyclidine were studied in spontaneously beating right atrial muscle and electrically paced left atrial muscle preparations isolated from guinea-pig or rat hearts. In right atrial muscle preparations, phencyclidine (10-100 microM) decreased the frequency of spontaneous beating. Guinea-pig and rat heart preparations had similar sensitivities to this action of phencyclidine. The negative chronotropic effect was not altered by atropine. A high concentration of naloxone failed to affect the chronotropic effect of phencyclidine in guinea-pig muscle, but significantly reduced the effect in rat heart muscle preparations. Phencyclidine (1-100 microM) caused positive inotropic effects in both guinea-pig and rat heart left atrial muscle electrically stimulated at 1.5 Hz; rat heart preparations had a higher sensitivity to the positive inotropic action of phencyclidine. The positive inotropic effect was reduced by verapamil, nifedipine and relatively high concentrations of diltiazem, but was not affected by propranolol, phentolamine, tripelennamine, atropine or ryanodine, indicating that the effect is not mediated by adrenergic, histaminergic or cholinergic systems or does not involve ryanodine-sensitive calcium pools. Inactivation of the fast sodium channels by partial membrane depolarization, and subsequent restoration of the contraction by raising the extracellular Ca++ concentration, did not abolish the positive inotropic action of phencyclidine. These results suggest that the negative chronotropic effect of phencyclidine is not mediated by a stimulation of the muscarinic receptor. The positive inotropic effects of phencyclidine seem to result from an increase in Ca++ influx through the slow channels of the cardiac cell membrane.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30476049,"openaccessinfo":{"externalids":{"MAG":"1942037228","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Between 1976 and 1987, a total of 180 patients with small cell lung cancer who were entered into three protocol studies of an intensive chemotherapy with or without radiotherapy was fully evaluated for tumor response and survival. Of them, 74 patients achieved a complete response (CR) : 47 out of 91 patients with limited disease (LD) and 27 out of 89 patients with extensive disease (ED). The author analysed the pattern of relapse among the 74 patients in an attempt to clarify the role of chest irradiation and\/or prophylactic cranial irradiation. Of 47 patients with LD achieving a CR, 20 patients (43%) developed initial relapse in the chest and seven (15%) developed it in the brain. Of the 27 patients with extensive disease, the chest was also the most frequent site of initial relapse (44%) followed by the brain (19%). In patients with LD receiving chemotherapy plus chest irradiation, the rate of initial relapse in the chest and the cumulative actuarial probability for initial chest relapse 2 years later were 29% and 37%, respectively. These figures were siginificantly lower than the rate of 69% and the probability of 69% for patients receiving chemotherapy alone (p<0.05). The patient survival was improved by the addition of chest irradiation substantially, but not significantly. However, long-term disease-free survivors predominated in the group of patients receiving chemotherapy plus chest irradiation. Prophylactic cranial irradiation exerted no significant advantage for prolonging survival. However, it showed a trend for reducing the brain relapse in complete responders. These findings indicate that chest irradiation concomitant with intensive chemotherapy may be effective for prolonging suvival in patients with LD through preventing relapse from the chest.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":116387819,"openaccessinfo":{"externalids":{"MAG":"2154308008","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of iodinated contrast media (CM) continues to be a common cause of hospital-acquired acute renal failure (ARF) and its development increases the in-hospital mortality significantly. Alterations in renal hemodynamics and direct tubular toxicity by contrast media are the primary factors believed to be responsible for contrast media-associated nephrotoxicity. We review recent insights into the pathogenesis of this complication and summarize prophylactic strategies focussing on hydration, vasoactive pharmacological agents, alternative contrast media and \"prophylactic hemodialysis\".","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41137671,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The exact solution of a one-dimensional problem, representing the scattering of a particle by another particle which is bound to a fixed centre of force, is given. All the interactions have zero range and are described by boundary conditions. The possible processes are elastic scattering and break-up of the bound system. The elastic scattering and break-up amplitudes are explicitly determined, and the behaviour of the corresponding cross-sections is discussed. At high energies, the incident particle tends to transfer its whole momentum to the bound one, giving rise to a strong peak in the break-up cross-section. The analytic behaviour of the amplitudes is examined. The Riemann surface of the elastic scattering amplitude has three sheets. The break-up threshold gives rise to cubic-root branch points. The remaining singularities are a finite number of poles. The exact amplitudes are compared with those given by the impulse approximation (in first and second order) and by Born's approximation. It is found that these approximations are reliable only at high incident energies and within the width of the dominant peak of the break-up cross-section.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":122298772,"openaccessinfo":{"externalids":{"MAG":"2128513611","ACL":null,"DOI":"10.1098\/rspa.1961.0208","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An English lingua franca seems to be emerging in the ten ASEAN countries, and this paper investigates features of the pronunciation of this lingua franca. Twenty speakers, two from each of the ASEAN countries, were recorded while they were conversing in groups of three or four people, all from a different country. The speech that they used is analysed to identify shared features of pronunciation, especially to evaluate the effect that these features have on intelligibility, and it is argued that some of their shared non-standard features actually enhance intelligibility. Finally, some of the misunderstandings that occurred are analysed to determine the extent to which pronunciation played a part, and it is found that only those features of pronunciation not shared by speakers from other ASEAN countries resulted in a break-down in communication.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":143800950,"openaccessinfo":{"externalids":{"MAG":"2004472935","ACL":null,"DOI":"10.1111\/J.1467-971X.2006.00478.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A central control system is described which follows preset programs and automatically switches on or off up to 40 groups of remote operations\u2014each on its own time schedule. Utilizing carrier current signals, it operates over existing electric circuits and does not require the installation of any transmission wiring.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108587794,"openaccessinfo":{"externalids":{"MAG":"2020710165","ACL":null,"DOI":"10.1109\/EE.1955.6439500","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Oral health of pre-school children determines the oral health status of the future generations and it is dependent on knowledge, attitude and practices toward primary dentition among the parents of the pre-school children. Objective: To assess and compare the knowledge, attitude and practices towards primary dentition among the mothers of 3-5 year old anganwadi and play home children in Bangalore city. Methodology: A cross-sectional questionnaire survey was conducted among 1000 mothers of 3-5 year old pre-school children, 500 from anganwadi centers and 500 from play homes of Bangalore city. Data was collected through an interview, using a structured proforma. Results: Among the anganwadi mothers, 98.4% had poor knowledge, 49.0% exhibited fair attitude and 97.0% were following poor practices towards the primary dentition of their preschool children, where as none of them in this group neither had good knowledge nor followed good practices. Among the play home mothers, 79.8% had poor knowledge, 74.0% were following poor practices towards primary dentition, 1.0% had good knowledge and only 0.8% were following good practices, 44.8% and 42.6% mothers exhibited fair and good attitude towards primary dentition respectively. Conclusion: Even though attitude of the mothers from both the groups was found to be fair enough, their level of knowledge was low and practices followed towards primary dentition were found to be poor.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":220743508,"openaccessinfo":{"externalids":{"MAG":"2995558952","ACL":null,"DOI":"10.4103\/2319-5932.167739","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The evolution of life cycles involves transitions between discrete states in one or more of the characters that comprise a developmental pattern. In this paper, we examine three of the major life cycle characters and the states for these characters. Using examples from echinoderms, we discuss the evolutionary transitions that have occurred in the type of morphogenesis, developmental habitat, and mode of nutrition during development. We evaluate the functional requirements associated with these transitions to infer the likelihood (frequency or rapidity) of change in a given character and of biases in the polarity of character state transitions. Using comparisons of closely related species, we evaluate the change between states in one character for dependence on the state of, or correlated changes in, other characters. Based on our analysis of congeneric species that differ in developmental habitat, we conclude that the transition between pelagic and benthic development is an ecological change that is independent of changes in morphogenesis and should be reversible. In contrast, the transition from feeding to nonfeeding development has been considered to be irreversible because it involves marked changes in larval morphology. We re-examine the transition between different modes of larval nutrition in light of recent studies that show that there exists a continuum of nutritional strategies between planktotrophy and lecithotrophy. This continuum is largely determined by variation in maternal investment and does not involve alterations in larval morphology. We suggest that the boundary between planktotrophy and lecithotrophy is frequently crossed and that this transition is reversible. Ecological changes represent the crossing of a functional threshold. Only after crossing the threshold, do larvae experience qualitatively different selective pressures that can lead to subsequent changes in morphology and development. Two different changes have occurred in the type of morphogenesis: the simplification of larval morphology that is associated with obligate (nonfeeding) lecithotrophy and the loss of the larval body plan in the evolution from indirect to direct development. It is the modification of morphology independent of the ecological changes that requires alterations in developmental processes, constrains evolutionary options, imposes irreversibility, and establishes the discrete nature of larval patterns in marine invertebrates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53000399,"openaccessinfo":{"externalids":{"MAG":"1988650402","ACL":null,"DOI":"10.1111\/J.1095-8312.1997.TB01502.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article reports the results of an innovative application of traditional multivariate approaches to estimating hospital costs in order to support product-line evaluation of graduate medical education (GME) program costs among the clinical departments and teaching facilities of a nationwide, federal multi-institutional system. Department-level data for 1988, 1989, and 1990 were used to estimate a multiple regression model of total costs per disposition for the specialties of medicine, surgery, obstetrics\/gynecology, orthopedics, psychiatry, and pediatrics. Systemwide and facility-specific GME program costs per disposition were estimated for each specialty on the basis of dependent variable scores predicted by the regression model. Measures of case-mix intensity, facility bed size, department staff size, clinical specialty, GME status, teaching intensity, operating efficiency, and regional variation each made statistically significant contributions to the explained variance in total costs per disposition, and yielded an adjusted R2 of .701. Estimates of total costs and GME costs per disposition revealed substantial variation among clinical specialties, both systemwide and within specific facilities. The results of these techniques, their usefulness for enhancing executive ability to evaluate costs of GME programs as product lines, and their implications for public policy regarding hospital payments are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20035966,"openaccessinfo":{"externalids":{"MAG":"2405798158","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, the flame retardancy properties of huntite\/hydromagnesite mineral in plastic compounds were investigated for potential electrical applications. Before the production of composite materials, huntite\/hydromagnesite minerals were ground to particle sizes of 10, 1, and 0.1 \u03bcm. Phase and microstructural analysis of huntite\/hydromagnesite mineral powders were undertaken using XRD and SEM-EDS preceding the fabrication of the composite materials. The ground minerals with different particle size and content levels were subsequently added to ethylene vinyl acetate copolymer to produce composite materials. After fabrication of huntite\/hydromagnesite reinforced plastic composite samples, they were characterized using DTA-TG, FTIR, and SEM-EDS. Flame retardancy tests were undertaken as a main objective of this research. The size distribution and the mineral content effects are measured regarding the flame retardancy of the polymer composites It was concluded that the flame retardant properties of plastic composites were improved as the mineral content increased and the size was reduced. POLYM. COMPOS., 31:1692\u20131700, 2010. \u00a9 2010 Society of Plastics Engineers.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":137222704,"openaccessinfo":{"externalids":{"MAG":"2083840688","ACL":null,"DOI":"10.1002\/PC.20959","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present the in-field use of a recently developed on-line, real time, optical monitoring system for bi-disk rolling contact tests on railway-wheel- and rail- steel disks, based on laser illumination and a high-speed camera. Qualitative, as well as quantitative information can be obtained by the use of specific indexes derived from the images using blob analysis. Monitoring the tests provides information about the initial transients of turning-crest removal, on the steady state reached, and on the dynamics of the surface in between. Blob anisotropy is a key element to draw information of the mechanisms governing this intermediate state.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":139852476,"openaccessinfo":{"externalids":{"MAG":"2753320840","ACL":null,"DOI":"10.1088\/1742-6596\/882\/1\/012012","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/882\/1\/012012","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The control of liquid level in tank system and flow between tanks is main problem in process industries like petroleum refineries, chemical, paper industries, water treatment industries. The control of liquid level and flow between tanks which is must be controlled. The control of level of tank in the interacting system is the major task. As in the interacting process dynamics the dynamics of tank 1 affects the dynamics of tank 2 and vice versa. For the study purpose two tank interacting level process is considered. While simulating in MATLAB it is observed that: 1. In PI controller, the offset is removed but makes the system response slow. 2. In PID controller the system response is fast but there are oscillations and overshoot. 3. In Fuzzy Control Logic the performance is without overshoot, Faster settling time, Better set-point tracking and very minimum steady state error.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":47009301,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Manipulation of soft miniature devices is important in the construction of soft robots, wearable devices, and biomedical devices. However, transport of soft miniature devices is still a challenging task, and few studies has been conducted on the subject. This paper reports a droplet-based micromanipulation method for transporting miniature soft ribbons. We show that soft ribbons can be successfully picked up and released to the target location using water droplets. We analyze the forces involved during the process numerically and investigate the influence of the width of the ribbon on the deformation. We verify that the deformation of a soft ribbon caused by elasto-capillary phenomena can be calculated using a well-known equation for calculating the deflection of a cantilever beam. The experimental and theoretical results show that the deformability of a soft miniature device during manipulation depends on its width.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":204738772,"openaccessinfo":{"externalids":{"MAG":"2979463848","ACL":null,"DOI":"10.3390\/mi10100684","PubMedCentral":"6843512","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-666X\/10\/10\/684\/pdf?version=1570785020","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Cloud computing is being rapidly adopted across the IT industry, driven by the need to reduce the total cost of ownership of increasingly more demanding workloads. Within companies, private clouds are offering a more efficient way to manage and use private data centers. In the broader marketplace, public clouds offer the promise of buying computing capabilities based on a utility model. This utility model enables IT consumers to purchase compute resources on demand to fit current business needs and scale expenses associated with computing resources. Thus, cloud computing offers IT to be treated as an ongoing variable operating expense billed by usage rather than requiring capital expenditures that must be planned years in advance. Advantageously, operating expenses can be charged against the revenue generated by these expenses directly. In contrast, capital expenses incurred by the purchase of a system need to be paid at the time of purchase, but can only be depreciated to reduce the taxable income over the lifetime of the system.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-30":1}},"corpusid":17697780,"openaccessinfo":{"externalids":{"MAG":"1970599706","ACL":null,"DOI":"10.1109\/ICCD.2012.6378606","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUNDS AND AIMS\nNon-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR). We evaluated whether IR contributes to hepatocyte apoptosis, inflammation, and fibrosis in NAFLD.\n\n\nMETHODS\nForty-four teetotaller patients with biopsy-proven diagnosis of NAFLD were enrolled. Twenty-eight NAFLD patients with IR were compared with 16 subjects without IR. For apoptotic activity caspase 3 and 8, transcription nuclear factor kB (NF-kB), and anti-apoptotic Bcl-2 protein were determined through immunohistochemical methods.\n\n\nRESULTS\nHOMA-IR index was significantly correlated with the stage and caspase 3- and 8 levels (p= 0.001, 0.02, and 0.01, respectively). HOMA-IR index was independently associated with the severity of fibrosis (\ue062 = 5.9, p = 0.001), caspase-3 (\ue062 = 0.16, p = 0.001), and caspase-8 (b =0.032, p = 0.018) levels. TNF-sRp55 level was positively correlated with HOMA-IR index (p = 0.024). Patients with IR had significantly higher necroinflammatory grade, stage, caspase-3, and caspase-8 levels than those without IR (p = 0.022, 0.007, 0.031, and p = 0.011, respectively). HOMA-IR index had statistically significant values for distinguishing of severe necroinflammatory grade, stage and for differentiating NASH from simple fatty liver (AUC = 0.78, 0.76, and 0.82, respectively).\n\n\nCONCLUSION\nThis study demonstrates that IR in NAFLD is associated with enhanced hepatocyte apoptosis and histopathologic disease severity. These data indicate that NAFLD patients with IR may have increased risk for disease progression.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4633485,"openaccessinfo":{"externalids":{"MAG":"2989671702","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: The purpose of this study was to evaluate the efficacy and safety of mexiletine, a medication with antiarrhythmic, anticonvulsant and analgesic properties, in treatment-resistant bipolar disorder patients. Methods: Twenty subjects with rapid-cycling bipolar disorder who had failed to respond or were intolerant to lithium, valproic acid and carbamazepine were entered into the 6-week, open label study. Subjects were followed on a weekly basis for dosing of mexiletine, blood levels, and completion of the Hamilton Depression Rating Scale (HAM-D) and the Manic State Rating Scale (MSRS). ''Burden of Mood Symptoms'' (BMS) was calculated by combining scores for the HAM-D and MSRS. Results: Thirteen subjects (10 female, 3 male), mean age 41 years (S.D. 5 7.6), and mean duration of illness 20 years (S.D. 5 7.7) completed the study. The dose range of mexiletine was 200-1200 mg \/ day. Full response ( $ 50% reduction in BMS) was seen in 46% of the subjects, and a partial response (25-49% reduction in BMS) in 15%. Of note, 5 \/ 5 subjects with a mixed or manic state demonstrated a full or partial response. Limitations: This study has an open label design, and a small number of subjects. Conclusions: Mexiletine may be effective and safe in patients with highly treatment-resistant, chronic bipolar disorder. Randomized, controlled trials are required to confirm the current results. \u00a9 2000 Elsevier Science B.V. All rights reserved.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":147269659,"openaccessinfo":{"externalids":{"MAG":"2290403011","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We construct a dynamic multi-agent moral hazard model to analyze the interactions among the firm owner, the manager and the auditor. Moral hazard may arise in hierarchical agency because a rational monitoring agent may accept a side payment from the monitored agent for misrepresenting information to the principal. This multi-agent moral hazard problem is the essence of the concern for auditor independence. We show that a ?low-balling? compensation scheme and the auditor's legal liability constitute an efficient dynamic contracting mechanism for hierarchical agency. In particular, low balling serves as a substitute for legal liabilities for maintaining auditor independence. Low balling reduces the transaction costs associated with the audit engagement relative to the flat-fee structure and can actually improve auditor independence.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":166632995,"openaccessinfo":{"externalids":{"MAG":"147250548","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This dissertation comprises three studies that investigated the construct of hedging as a decision making strategy in individuals with Obsessive-Compulsive Disorder (OCD). Hedging refers to the tendency to keep options available when there is a threat of loss of the options that is motivated by the underlying construct of loss aversion (i.e., Prospect Theory). Hedging introduces a behavioural economic approach to the study and understanding of the impact of loss aversion on decision making.\n\nParticipants played two conditions of the Doors Game (Shin & Ariely, 2004) in which they were instructed to maximize their earnings by tapping three doors in any order: i) constant availability (CA), where all doors remain available; and ii) decreasing availability (DA), where doors fade and disappear if left untapped after a short time (to elicit hedging). In Study One, undergraduates (N = 108) played both the CA and DA conditions and evidence indicates more frequent switching in the DA than the CA condition. There was also a significant negative association between hedging and the cognitive concern subscale of anxiety sensitivity. Study Two examined other psychological correlates of hedging in another undergraduate sample (N = 63) and yielded significant negative associations with the physical component of state anxiety and experience seeking. In Study Three, the results of a comparison of hedging among OCD, Gambling Disorder (GD), and Healthy Control (HC) groups yielded no significant differences. Correlates of hedging, however, differed among the groups and regression analyses suggest that hedging in OCD is negatively predicted by obsessiveness and decisiveness (subscale of the Need for Cognitive Closure; NFC), and positively predicted by experience seeking (subscale of the Sensation Seeking Scale). In the GD group, closed-mindedness (subscale of NFC) positively predicted hedging. In the HC group, fun-seeking (subscale of Behavioral Inhibition and\nBehavioral Activation Scale) positively predicted hedging.\n\nImplications: This work is the first to demonstrate predictors of hedging in OCD using a loss aversion paradigm where evidence suggests that obsessional and motivational drives lead to premature choice selection. Pursuing the loss aversion perspective could significantly advance the decision making research in OCD and in other clinical populations.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":240835356,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32920\/ryerson.14655960.v1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32920\/ryerson.14655960.v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Previous photoselection measurements showed that if the excitation is weak no optical anisotropy changes appear in immobilized purple membranes during the photocycle. The present study demonstrates that surprisingly at stronger excitations the anisotropy changes versus time. At 412 nm the dichroic ratio decreases after a few milliseconds, while at 570 nm the similar decrease is followed by an increase. The phenomenon cannot be described by tiltings of the retinal chromophore. It is the consequence of the cooperative interaction among the photocycling bacteriorhodopsin molecules that regulates the yields of more than one (expectedly two main) parallel pathways existing in the millisecond time domain of the photocycle.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24467226,"openaccessinfo":{"externalids":{"MAG":"2072167283","ACL":null,"DOI":"10.1006\/BBRC.1997.6494","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract\n Background: Chang-Kang-Fang formula (CKF), a multi-herb traditional Chinese medicinal formula, has been clinically used for treatment of irritable bowel syndrome with diarrhea (IBS-D). Though we have reported the compounds of CKF and the therapeutic effect on IBS-D rats, the exact mechanism underlying is still not clear. The aim of this study is to clearly define the effect of CKF on IBS-D by regulating gut microbiota and gut-brain axis. Method: We investigated the effects of CKF on IBS-D rat model, established by psychosocial stress (restraint) combined with the peripheral stimulation (senna leaf gavage) stress. The changed of body weight and the number of fecal pellets was investigated during the experiment. The effect on intestinal sensitivity was assessed based on the abdominal withdrawal reflex (AWR) scores and the intestinal permeability, the expression of ZO-1, measured by immunohistochemistry. The effect of CKF on gut-brain axis was evaluated by the expression of 5-HT through immunohistochemistry. The composition of gut microbiota was detected through 16sRNA. Results: Administration of CKF significantly have shown the therapeutic effect on IBS-D rats, involving decreased the score of AWR and increased the number of pellets, though there were no different on body weight change. In addition, CKF could upregulated the expression of ZO-1 in colon and downregulated the expression of 5-HT in colon and brain Moreover, CKF could rebalance the gut microbiota of IBS-D, increasing the abundance of Lactobacillu, Allobaculum, Roseburia and Lachnospiraceae_NK4A136. Conclusion: CKF potentially alleviates IBS-D through regulating gut microbiota and gut-brain axis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":241934629,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-22131\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-22131\/v1.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0In the 1970s, Mariner and Viking observed features in the Mars northern polar region that were a few hundred kilometers in diameter with 20 \u03bcm brightness temperatures as low as 130 K (considerably below CO2 ice sublimation temperatures). Over the past decade, studies have shown that these areas (commonly called \"cold spots\") are usually due to emissivity effects of frost deposits and occasionally to active CO2 snowstorms. Three Mars years of Mars Global Surveyor Thermal Emission Spectrometer data were used to observe autumn and wintertime cold spot activity within the polar regions. Many cold spots formed on or near scarps of the perennial cap, probably induced by adiabatic cooling due to orographic lifting. These topographically associated cold spots were often smaller than those that were not associated with topography. We determined that initial grain sizes within the cold spots were on the order of a few millimeters, assuming the snow was uncontaminated by dust or water ice. On average, the half-life of the cold spots was 5 Julian days. The Mars global dust storm in 2001 significantly affected cold spot activity in the north polar region. Though overall perennial cap cold spot activity seemed unaffected, the distribution of cold spots did change by a decrease in the number of topographically associated cold spots and an increase in those not associated with topography. We propose that the global dust storm affected the processes that form cold spots and discuss how the global dust storm may have affected these processes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":140165807,"openaccessinfo":{"externalids":{"MAG":"2053094863","ACL":null,"DOI":"10.1029\/2008JE003243","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Soil test has an important role in plant nutrition management to obtain the economical agriculture system. The nutrient concentration in soils that indicates the division between responsive and non-responsive conditions is termed the critical level. Before any fertilizer recommendation, we should be aware of the amount of nutrient critical levels in each region. Soil test results in an area, is not applicable for other agricultural areas. Therefore, these tests should be carried out in the soils of a desired area, so that the soil test could be the base for fertilizer recommendation. Iron is an essential micro element in the soil that mainly was found as insoluble (Ferric or Fe3+) form. Solubility of total inorganic iron decreases between pH 7.4 to 8.5. Bean (Phaseolus vulgaris L.) crop is one of the most widely grown throughout the Markazi province in Iran and has high nutritional value for human. Knowing that bean is a sensitive plant to iron, and because of lack of any information about iron critical level and regional calibration, this study was conducted in Markazi province. \nMaterials and Methods: Eighteen soil surface samples (0-30 cm) selected with a wide range of soil properties and iron concentration (extracted with DTPA method) from different zone of province and prepared for greenhouse cultivation. Soil physical and chemical properties such as: (texture, pH, calcium carbonate, organic matter, cation exchange capacity, and electrical conductivity) of soil were determined by routine laboratory methods. In this study, bean plant responses were investigated by application of two levels of iron (0 and 10 mg kg-1) in soil as iron sulfate in the greenhouse experiment. All of soil samples received nitrogen, potassium, phosphorus, manganese, copper and zinc as; (150, 100, 25, 5, 5, 5) mg kg-1 as solution in each pot respectively. The greenhouse study was conducted in a factorial experiment with three replications as complete randomized design. Six bean seeds were planted in pots. After the second week three plants of these six seeds were kept. \nSoil moisture was maintained at field capacity. At the end of vegetative phase, the shoot bean and iron concentrations were determined in plant samples. At the end of the vegetation period, the shoot parts of plants cut, and plant responses including; (dry matter weight, Fe concentration, total Fe uptake and relative yield) (DMcontrol.\/DMFe fertilizer*100) were determined. \n \nResults and Discussion: The results showed that available iron content in the soil varied from 1.5 to 20 mg kg-1 of soil with a mean value of 7.75 mg kg-1. The bean plant responded to Fe application and their relationships with physical and chemical properties of soils, which were investigated were effected too. Analysis of variance showed that the effects of soil and Fe fertilizer application were separately significant at 1% level for (weight dry matter, Fe concentration and Fe uptake). The effects of the (soil and fertilizer) interaction were significant at 1% level for the Fe concentration and Fe uptake. The mean comparison test of plant responses was significant as affected by Fe fertilizer consumption. By using Cate-Nelson graphic method, the critical level of iron in soils was five mg kg-1. Amounts of percent relative frequency indicated that eight percent of the soils were less than five mg kg-1 Fe, 63% of soils between 5 to 10 mg kg-1, 16% of soil between 10 to 15 mg kg-1 and 13% of soil above 15 mg kg-1 Fe. Plant Fe concentration in the control treatment (without Fe application) was 439.4 (mg kg-1), but at the Fe treatment (10mg kg-1) increased to (534.4mg kg-1). \nThe Fe uptake significantly increased from 1.54 to 2.16 mg Fe pot-1 with the application of 10 mg-Fe kg-1. The Fe uptake differences between treatments was due to increase of dry matter weight, and the plant Fe concentration, and this was due to the fertilizer application. Relative yield and dry matter weight showed positive and significant correlation with (clay, CEC and Fe available), but sand revealed negative correlation with the plant's response. The Fe uptake showed positive and significant correlation with Fe available but negative and significant correlation with the sand. The regression equation showed that Fe uptake to be related with CEC significantly. \nConclusion: By using Cate-Nelson graphic method, the critical level of iron in soils was five mg kg-1. The plant parameters were predictable significantly by soil properties such as (clay, sand, silt, soil organic carbon and Fe concentration).","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":136292103,"openaccessinfo":{"externalids":{"MAG":"2679337235","ACL":null,"DOI":"10.22067\/jsw.v31i4.57439","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The expression of specific keratin intermediate filaments during differentiation of rat type II pneumocytes in primary culture on various matrices was investigated. Changes in keratin expression were assessed using a monoclonal antikeratin antibody, 24A3, known to react strongly with alveolar epithelial cells in injured lung. Type II cell differentiation was modulated by culture on extracellular matrices known to either accelerate or retard loss of differentiated morphology and metabolic function. During culture on a plastic or fibronectin-rich surface, loss of cell differentiation correlates with increased staining with 24A3 antikeratin antibody by indirect immunofluorescence and with increased abundance of a family of acidic 46,000-dalton keratin isoforms detected in two-dimensional polyacrylamide gels of type II cell cytoskeletal extracts. Loss of type II cell differentiation is retarded or prevented by culture on substrata of purified laminin or of EHS tumor-derived basement membrane (matrigel). 24A3-linked fluorescence and expression of the 46 kDa keratins are reduced in parallel, although at 7 days in culture on matrigel or laminin, keratin expression increases. The results show that changes in type II cell differentiation effected in primary culture by the extracellular matrix correlates with changes in expression of the 24A3-reactive keratins. Loss of differentiated shape and function favors expression of these cytoskeletal antigens, which may provide quantifiable markers of the type II to type I cell transition that occurs during alveolar remodeling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24424353,"openaccessinfo":{"externalids":{"MAG":"1995579748","ACL":null,"DOI":"10.1164\/AJRCCM\/139.2.343","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The art of health planning is relatively new in many developing countries and its record is not brilliant. However, for policy makers committed to sustainable health improvements and the principle of equity, it is an essential process, and in need of improvement rather than minimalization. The article argues that the possibility of planning playing a proper role in health care allocative decisions is increasingly being endangered by a number of developments. These include the increasing use of projects, inappropriate decentralization policies, and the increasing attention being given to NGOs. More serious is the rise of New Right thinking which is undermining the role of the State altogether in health care provision. The article discusses these developments and makes suggestions as to possible action needed to counteract them.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21341534,"openaccessinfo":{"externalids":{"MAG":"2023913928","ACL":null,"DOI":"10.1093\/HEAPOL\/10.1.22","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A novel sulfatase gene, ary423 (1,536 bp ORF), encoding a protein of 511 amino acids with a calculated molecular mass of 56 kDa, was identified from Flammeovirga pacifica, which was isolated from deep-sea sediments of west Pacific Ocean. Amino acid sequence analysis revealed that Ary423 possessed a conserved C-X-A-X-R motif, which was recognized as the sulfatase signature. Phylogenetic analysis suggested that Ary423 belonged to arylsulfatases. After heterologous expression in Escherichia coli cells, the recombinant Ary423 was purified with a Ni(+) affinity column, and was shown to be highly active at a broad range of temperatures from 30\u00b0 to 70\u00b0C, with maximum activity at 40\u00b0C. Furthermore, recombinant Ary423 retained more than 70% and 40% of its maximum activity after 12 h of incubation at 50\u00b0C and 60\u00b0C, respectively, exhibiting good thermostability at high temperatures. The optimal pH for Ary423 was determined to be 8.0 and the activity of Ary423 could be slightly enhanced by Mg(2+). The recombinant enzyme could hydrolyze sulfate ester bonds in pnitrophenyl sulfate (NPS) and Asparagus crude polysaccharides with a specific activity of 64.8 U\/mg and 25.4 U\/mg, respectively. These favorable properties could make Ary423 attractive for application in the desulfating process of agar production.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22525826,"openaccessinfo":{"externalids":{"MAG":"1197896727","ACL":null,"DOI":"10.4014\/jmb.1504.04028","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jmb.or.kr\/journal\/download_pdf.php?doi=10.4014\/jmb.1504.04028","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper seeks to contribute to better understanding of information within the information systems (IS) discipline. It argues that a hierarchical view on data-information-knowledge-wisdom \u2013 dominant in the IS discipline \u2013 is limited and that numerous other attempts to conceptualize information are worthy of exploration. The paper thus reviews literature on conceptualizing and theorizing information within and beyond the IS literature and proposes further theoretical development. Five different views on information are identified: material, engineering, objectivist, subjectivist, and inter-subjective. Underlying assumptions, examples and a critical discussion of each viewpoint are provided. The paper then proposes a sociomaterial and performative account of information according to which, information is seen to create reality rather than simply represent it.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":2852958,"openaccessinfo":{"externalids":{"MAG":"1551742317","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : Channel erosion in small upland watersheds is the general topic of this research effort. Specifically, the effort is directed toward fundamental mechanics of channel erosion resulting from the development of channel (gully) headwalls and scour holes, from channel sidewall failure and from general shear excess. The emphasis is on erosion in cohesive channel materials. Entry of sediment into our nations waterways is a serious pollution problem, intensified by the chemicals adsorbed on the exchange phase of clay particles in the sediment. The subject of upland erosion form rill and interrill areas has been the subject of intensive investigations, both empirical and physically based. Channel erosion has been studied primarily from an empirical basis, with virtually little physically based information on channel headwall development and propagation and of channel bank failure. In the research conducted under this project, models are developed which predict channel erosion resulting from shear in gradually varied flow, shearing forces resulting from submerged and partially submerged jets and shearing forces resulting from free jets impinging a plunge pool. These models are linked with a runoff routing algorithm to develop the channel model. This model predicts general channel erosion resulting from time varying gradually varying flow as well as predicts the development and propagation of channel headwalls.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107785207,"openaccessinfo":{"externalids":{"MAG":"172812565","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The rise of China as the global factory raises challenges for many develop- ing countries and their producers. The football-manufacturing sector is a case in which China has emerged as a global player. It is also a sector where compliance with international labour standards is considered critical. Leading international brands dominate the industry and control the global value chain for sports goods. In this article, we explore the relationship between the rise of China and international labour standards and consider how labour standards have affected the geography and organization of global football production. We draw on evidence from three of the main production locations - China, Pakistan and India. It appears that compliance with labour standards not only has different implications for the three production locations, but also that compliance alone is an insufficient basis for competing against China.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":154500693,"openaccessinfo":{"externalids":{"MAG":"2080262036","ACL":null,"DOI":"10.1111\/J.1471-0374.2011.00329.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"LU and Cholesky matrix factorization algorithms are core subroutines used to solve systems of linear equations (SLEs) encountered while solving an optimization problem. Standard factorization algorithms are highly efficient but remain susceptible to the accumulation roundoff errors, which can lead solvers to return feasibility and optimality certificates that are actually invalid. This paper introduces a novel approach for solving sequences of closely related SLEs encountered in nonlinear programming efficiently and without roundoff errors. Specifically, it introduces rank-one update algorithms for the roundoff-error-free (REF) factorization framework, a toolset built on integer-preserving arithmetic that has led to the development and implementation of fail-proof SLE solution subroutines for linear programming. The formal guarantees of the proposed algorithms are formally established through the derivation of theoretical insights. Their computational advantages are supported with computational experiments, which demonstrate upwards of 75x-improvements over exact factorization run-times on fully dense matrices with over one million entries. A significant advantage of the proposed methodology is that the length of any coefficient calculated via the associated algorithms is bounded polynomially in the size of the inputs without having to resort to greatest common divisor operations, which are required by and thereby hinder an efficient implementation of exact rational arithmetic approaches.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":246441801,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dietary treatment of alimentary disease has long been considered important and bewildering varieties of diet have been recommended for most gastrointestinal conditions. While the rationale for some diets is based on firm scientific evidence, others are justified only by alleged symptomatic benefit which has not been confirmed by controlled trials. In this review, we list briefly some of the alimentary diseases in which dietary modifications are necessary or are of possible benefit.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":25892736,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/dtb.12.19.73","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many modern retail stores have self-checkout stations where customers can ring up their own orders without the assistance of any store personnel. To promote customer honesty these systems often weigh each item as it is placed in the bag to confirm that it has the expected mass for the product scanned. In our system we augment this basic check with an assessment of the item's visual appearance to further ensure that the correct code has been entered.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":19028988,"openaccessinfo":{"externalids":{"MAG":"2111607978","ACL":null,"DOI":"10.1109\/WACV.2011.5711557","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present article an analysis of borders diverse kinds and functions applied in psychological concepts and paradigms has been carried out. It has been made clear that a comprehension of borders as a self-valuable source for development ousts metaphorical and topological interpretations of the term. It has been alleged that within the context of social psychology it is righteous to discuss intersubject and intersubjective borders of interaction between I and the Other.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262194464,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.18500\/1819-7671-2011-11-1-89-94","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"of Licentiate Thesis Author Timo Punkka Title of Thesis Flexible New Product Development: Using Knowledge Transfer from Agile Software Development as a Catalyst for Adaptation \u2013 Case Study and Systematic Literature Review Abstract The life cycle of products is getting shorter and product development projects are more than ever challenged by frequent change. In response to this evolution, Agile software development is gaining a foothold in the software industry. Agile software development relies on iterations, collaboration between organizational functions and re-planning based on feedback from past iterations. Product development experts have suggested similar approaches to new product development in general. However, the adaptation rate has been faster in the software domain. This work studied knowledge transfer from Agile software development to product development involving other engineering disciplines. The research consisted of two parts, a case study and systematic literature review.The life cycle of products is getting shorter and product development projects are more than ever challenged by frequent change. In response to this evolution, Agile software development is gaining a foothold in the software industry. Agile software development relies on iterations, collaboration between organizational functions and re-planning based on feedback from past iterations. Product development experts have suggested similar approaches to new product development in general. However, the adaptation rate has been faster in the software domain. This work studied knowledge transfer from Agile software development to product development involving other engineering disciplines. The research consisted of two parts, a case study and systematic literature review. The first part of the research was a case study in an industrial setting. The case project involved teams developing electronics and mechanics. The study identified that the project benefited from knowledge transfer from Agile software development. It resulted in accelerated learning, improved communication and higher commitment. The study also identified several challenges remaining in knowledge transfer, such as larger organizational change, documentation level and the need to adapt to engineering practices. As a second part of the research, a systematic literature review was conducted to find out what is currently known about the subject. The review found three common themes: co-design, testing and incremental hardware development. Extended collaboration between engineering disciplines was seen as important, but iterative development relying on experimentation needs new techniques for continuous testing. Despite the challenges, iterative hardware development is seen to be beneficial to system development projects. The synthesis part of the review identified an enforcing cycle between the three themes, resulting in diminishing difference between engineering disciplines. Based on the results, it is recommended to transfer knowledge from Agile software development to new product development in general. The knowledge available accelerates the adaptation rate to a more flexible approach to development. Furthermore, it was identified that the change in product development triggers a need for change in other functions of the organization, leading toward an Agile organization. The results from the studies were mapped to a conceptual framework on how an Agile organization works. During the study, several future research avenues were identified, such as how Agile Development affects the whole organization, the economics of frequent prototyping and engineering practices, particularly regarding test automation and integration with quality assurance approaches and processes such as CMMI and ISO 9001. Research field","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":113333416,"openaccessinfo":{"externalids":{"MAG":"2282501921","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Corneal epitheliopathy is a commonly seen disease in the clinical work. However, due to its complicated causes, there remain misdiagnosis and mistreatment, which would aggravate epithelial keratopathy and induce corneal scars, eventually leading to irreversible visual impairment. In this article, the primary and secondary causes of corneal epithelial lesions are described in detail. The classification, diagnosis and treatment principles of the disease are also presented to arouse more concern about corneal epitheliopathy. (Chin J Ophthalmol, 2017, 53: 161-163).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34202611,"openaccessinfo":{"externalids":{"MAG":"2964712557","ACL":null,"DOI":"10.3760\/cma.j.issn.0412-4081.2017.03.001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The prevalence and intensity of intestinal parasites in the domestic goats at St. Katherine\\'s protectorate and their relation to some ecological and biological factors that might possibly influence parasite load were investigated. Faecal samples from 164 goats, housed in three different sites during two seasons, (Aug-Sept 2001 and Jan-Feb 2002) were examined for egg or oocyst numbers per gram (EPG or OPG) as indices of parasite load. Nematodirus sp. (Nematoda) and Eimeria sp. (coccidian protozoa) were the dominant intestinal parasites. Only few cases showed high EPG (>200) or OPG (>500) while others showed subclinical levels of infection. Marked seasonal variations were observed, higher in Aug-Sept (dry season) than in Jan-Feb (wet season). There were significant differences among sites, perhaps caused by many factors including site topography, feeding habits, diet or health status. OPG increased dramatically in ungrazed and EPG increased in grazed goats. OPG was affected by sex, age class and female status but this was not the case for EPG. There was a significant correlation between OPG and host size. We conclude that differences in parasite loads are determined by both environmental and biological factors. KEY WORDS: goats, Nematodirus, Eimeria , season, site, food, sex, age. Egyptian Journal of Botany Vol.5 2003: 78-85","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":56266112,"openaccessinfo":{"externalids":{"MAG":"2159105316","ACL":null,"DOI":"10.4314\/EJB.V5I1.29976","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Breast cancer is the most commonly diagnosed cancer and the second most leading cause of death next to cervical cancer in Ethiopia. An economic burden of breast cancer is a considerable issue in most middle and low income countries, especially in Ethiopia, where there is high out-of-pocket expenditure for health. \nObjectives: To estimate Economic burden of breast cancer patients on chemotherapy attending at Tikur Anbessa Specialized Teaching Hospital (TASH) and to determine Predictors for variation in patient related cost of breast cancer patients on chemotherapy. \nMethods: The Cost of illness study on 349 breast cancer cases was carried out at Tikur Anbessa Specialized Teaching Hospital (TASH) using cross sectional study design. A Simple random sampling method was used to select study participants. As a semi-structured questionnaire was used to collect data, mean, median and standard deviation were used to calculate direct cost indirect cost and companion side costs. Multiple linear regression analysis was employed to analyze the separate effects of the various predictor variables on cost of treatment. \nResults: The average outpatient direct cost at Tikur Anbessa Specialized Teaching Hospital for breast cancer on chemo-therapy was 24953.45 ETB ($1188.26) SD (=24874.77{$1184.51}). Direct medical cost comprised the largest part (mean=18753.41 ETB (893.02 USD) (SD=18860.95 ETB) $898.14). Mean expenses for non-prescribed remedies was, 6200.00 birr ($295.24), takes the lion share of direct nonmedical cost followed by expense for transportation (mean=3568.31 ETB {$169.92). \nConclusion: This study shows that the financial burden of breast cancer is substantial and overwhelming for both patients and their families. Outpatient treatment cost was found to be dependent on number of employed household members, number of facility visited. Longer duration of inpatient hospital stay and stages of breast cancer is associated with inpatient cost and indirect cost.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":54715928,"openaccessinfo":{"externalids":{"MAG":"2788348200","ACL":null,"DOI":"10.4172\/2471-268X.1000142","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Liver cirrhosis (LC) is the final evaluative stage of chronic liver diseases with dynamic progressive process to multiple complications especially splenomegaly and esophageal varices(EV). Efforts have been made to develop non-invasive predictive models that may correlate with LC and EV. The role of liver stiffness measurement (LSM)- and spleen stiffness measurement (SSM) by transient elastography (TE) in the diagnosis of LC and prediction of EV was studied on 90 subjects selected from the outpatient clinics of Bakhash Hospitals. They were classified into three groups: GI included 10 healthy volunteers as a control group, GII included 20 chronic hepatitis (CH) patients and GIII included 60 cirrhotic patients. Patients in GIII were further subdivided equally into two subgroups A & B according to presence or absence of EV. GIII patients were evaluated by gastroscope for screening and grading of EV. All groups were subjected to complete blood picture, liver and kidney function testes and abdominal ultrasonography as well as LSM (right lobe) and SSM by using fibroscan. LS were significantly higher in LC patients as compared with CH patients and controls. At a cutoff value of 9.8 kPa, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) for LC were 90%, 73%, 55% &78% respectively. At a cutoff value of 17.75 kPa (no varices vs. varices at any grade), sensitivity, specificity, PPV & NPV for prediction of EV were 92%, 46.2%, 73% & 67.2% respectively. LS at cut off values of 14.4 KPa predicted the splenomegaly. SSM at 50.4 KPa being the best cut-off value for prediction of varices with sensitivity, specificity, PPV, NPV & accuracy were 81.2%, 73.2%, 88.7%, 48.8% & 79.4% respectively. Combination of LS >17 KPa & SS > 52, predicted EV with 87.6% diagnostic accuracy. As regard EV prediction, combination of LSM & SSM had a highest diagnostic accuracy than PSR (76.9% vs. 87.6).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23029090,"openaccessinfo":{"externalids":{"MAG":"2324218806","ACL":null,"DOI":"10.12816\/0006297","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"As the two researchers were once in Malaysia, they both realized the Malaysian role in supporting the Palestinian people and their cause; thus, they tended to prepare this study throughout benefiting from their observations, extrapolating audio-visual and readable media tools, and analyzing reports issued by the Malaysian institutes in Palestine. All of those written and visual reports are the materials of the study, which falls within surveys. This study determines the nature of the Palestine-Malaysia relationship, reads its future, recognizes the fields of Malaysian support for Palestine, and focuses on the impact of this support over the Palestinians' steadfastness and resistance. It addresses four claims: Malaysian-Palestinian Relations, Malaysian Support for the Palestinian Cause, Malaysian Facilities in the Gaza Strip, and Research Institutes on Jerusalem in Malaysia. The study results show that the official and popular relations between Palestine and Malaysia are getting stronger and the Malaysian support to the Palestinian cause is continuously growing. It finally recommends enlisting a special media discourse towards the Malaysian people and government that fits their social and cultural reality and to enhance the relations between both nations throughout empowering the diplomatic representation between them.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":246502000,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.36099\/ajahss.4.1.8","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/doi.org\/10.36099\/ajahss.4.1.8","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Abstract The present study was aimed to assess the diversity of influenza A viruses (IAV) circulating in pig farms in the Iberian Peninsula. The study included two different situations: farms suffering respiratory disease outbreaks compatible with IAV (n = 211) and randomly selected farms without overt respiratory disease (n = 19). Initially, the presence of IAV and lineage determination was assessed by qRT\u2010PCR using nasal swabs. IAV was confirmed in 145 outbreaks (68.7%), mostly in nurseries (53\/145; 36.5%). Subtyping by RT\u2010qPCR was possible in 94 of those cases being H1avN2hu (33.6%), H1avN1av (24.3%) and H1huN2hu (18.7%), the most common lineages. H3huN2hu and H1pdmN1pdm represented 7.5% and 6.5% of the cases, respectively. As for the randomly selected farms, 15\/19 (78.9%) were positive for IAV. Again, the virus was mostly found in nurseries and H1avN2hu was the predominant lineage. Virus isolation in MDCK cells was attempted from positive cases. Sixty of the isolates were fully sequenced with Illumina MiSeq\u00ae. Within those 60 isolates, the most frequent genotypes had internal genes of avian origin, and these were D (19\/60; 31.7%) and A (11\/60; 18.3%), H1avN2hu and H1avN1av, respectively. In addition, seven previously unreported genotypes were identified. In two samples, more than one H or N were found and it was not possible to precisely establish their genotypes. A great diversity was observed in the phylogenetic analysis. Notably, four H3 sequences clustered with human isolates from 2004\u201305 (Malaysia and Denmark) that were considered uncommon in pigs. Overall, this study indicates that IAV is a very common agent in respiratory disease outbreaks in Spanish pig farms. The genetic diversity of this virus is continuously expanding with clear changes in the predominant subtypes and lineages in relatively short periods of time. The current genotyping scheme has to be enlarged to include the new genotypes that could be found in the future.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":220335985,"openaccessinfo":{"externalids":{"MAG":"3040500533","ACL":null,"DOI":"10.1111\/tbed.13709","PubMedCentral":"8246522","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/tbed.13709","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND OBJECTIVE\nThe lung immune prognostic index (LIPI), a simple index calculated from the blood lactate dehydrogenase level and derived neutrophil-to-lymphocyte ratio, is thought to be associated with host immune status. However, the utility of LIPI in patients with idiopathic interstitial pneumonias (IIPs) is unknown.\n\n\nMETHODS\nIn this multicentre, retrospective, observational study, an association between LIPI and the survival of patients with IIPs was evaluated.\n\n\nRESULTS\nExploratory and validation cohorts consisting of 460 and 414 patients with IIPs, respectively, were included (159 and 159 patients had idiopathic pulmonary fibrosis [IPF], and 301 and 255 had non-IPF, respectively). In the exploratory cohort, patients with IPF and a low LIPI had significantly better survival than those with a high LIPI (median of 5.6\u2009years vs. 3.9\u2009years, p\u2009=\u20090.016). The predictive ability of LIPI for the survival of patients with IPF was validated in the validation cohort (median of 8.5\u2009years vs. 4.4\u2009years, p\u2009=\u20090.003). In a multivariate Cox proportional hazard analysis, LIPI was selected as an independent predictive factor for the survival of IPF patients. There was no significant association between LIPI and survival of non-IPF patients in the exploratory and validation cohorts.\n\n\nCONCLUSION\nThe LIPI was a predictive factor for the survival of patients with IPF and could aid the management of IPF.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264973528,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/resp.14621","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/resp.14621","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Smoke from wildland fire is a growing concern as air quality regulations tighten and public acceptance declines. Wildland fire emissions inventories are important not only for understanding air quality impacts from smoke but also in quantifying sources of greenhouse gas emissions. Calculation of wildland fire emissions can be done using a number of models and methods. Under the Smoke and Emissions Model Intercomparison Project, comparisons between different methodologies are being analyzed by examining model-to-model variability. In addition, the relative importance of uncertainties in fire size information, available fuels information, consumption modeling techniques, and emissions factors are being compared. This work highlights the need for accurate fire information that integrates information from multiple datasets. We present a new effort that upgrades the SMARTFIRE-BlueSky Framework, providing constraints on fire information and other errors in the modeling chain, and resulting in an improved wildland fire emissions inventory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":55232192,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A mutant phenotype isolated from alfalfa (Medicago sativa L) cv. Excalibur appeared to have dramatic changes in source-sink relations and the partitioning of carbohydrates. Leaves emerged normally, but starch accumulated in the chloroplasts of the palisade mesophyll cells with maturity. Subsequently, the cells of the palisade layer lost chlorophyll, exhibited ultrastructural symptoms of senescence, and necrotic spotting appeared on the adaxial surface of fully expanded leaves. Segregation analysis of this phenotype, designated as hls (high-leaf starch), with F 1 , BC 1 , and F 2 progenies revealed that two independent dominant genes condition the trait. The hls phenotype had five-fold more starch in mature leaves and less in the taproot than in the normal leaf phenotypes, suggesting a blockage in transport of carbohydrate from the leaf to the root. In vitro activity assays and native polyacrylamide gel electrophoresis (PAGE) analysis revealed that most enzymes involved in carbohydrate metabolism were not altered in the hls phenotype. However, invertase activity of expanding leaves was significantly higher in plants with the hls phenotype than in those with a normal phenotype. The visual appearance of the mutation, high leaf starch content, and high invertase activity co-segregated in the progeny. Native PAGE revealed that a fast-moving invertase isozyme (F) was developmentally inactivated in normal phenotypes during leaf expansion but remained active in the hls phenotype. A biochemical model for the his phenotype is proposed in which high invertase activity blocks phloem loading and reduces the availability of cytosolic inorganic orthophosphate for exchange with triose-phosphate across the chloroplast envelope, thereby promoting starch accumulation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":84811048,"openaccessinfo":{"externalids":{"MAG":"2010070631","ACL":null,"DOI":"10.2135\/CROPSCI1998.0011183X003800030018X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on the single particle energy spectrum of weak relativity and Poisson's formula,the thermodynamic potential function of Fermi gas in a strong magnetic field is derived. Furthermore, by using the thermodynamic relationships, the analytical expressions of statistic characteristic quantities of the system at low temperatures are obtained, and the influence mechanism of relativistic effect on the statistic properties of the system is analysed. It is shown that the relativistic effect becomes more significant with the magnetic field increasing. Compared with the corresponding oscillating amplitude, the monotonic term, which is caused by the relativistic effect, is much larger than the amplitude for the total energy, however, for the chemical potential and magnetic moment, they are almost of the same order.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":117275721,"openaccessinfo":{"externalids":{"MAG":"935789200","ACL":null,"DOI":"10.7498\/APS.60.100502","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study presents a damage localization method for building structures using dynamic displacement responses based on a convolutional neural network (CNN). The proposed method is based on the interrelation of dynamic displacement response measured from a building in a healthy state. Based on the interrelation constructed by CNN in advance, damaged stories are localized by investigating the discrepancy of dynamic responses between healthy and damaged states. Hence, this allows identification of the location of damage without the use of structural response labeled with damage information in the CNN training stage. Specifically, to construct the CNN presenting the interrelation of structural response of the building under the healthy state, dynamic displacement response is utilized in the both input and output of CNN. Then, when the building is suspected to be damaged, the displacement response measured from the building is used as an input data in the previously trained CNN. Based on the discrepancy between the output obtained by inputting damaged state response into CNN and the response in a healthy state, the location of damage in the building is identified. To express this discrepancy, indicators for damage localization are newly defined in this study, which can be calculated by healthy and damaged state responses with the trained CNN. Through the investigation of the distribution of those indicators extracted from multiple stories of the structure, the location of damage in building structures is identified. We validated the proposed method for identifying damage locations through a numerical study and an experimental study.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":225452658,"openaccessinfo":{"externalids":{"MAG":"3035486836","ACL":null,"DOI":"10.1002\/stc.2578","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1002\/stc.2578","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The primary aim of this study was to assess whether Fractional Exhaled Nitric Oxide (FeNO) and Nasal Nitric Oxide (nNO) can be used as a mean of diagnosis in Allergic Rhinitis (AR) without asthma or not , and discuss their correlation. Fifteen healthy children and thirty children with AR, but without asthma, were enrolled. A questionnaire about clinical features of AR children had been completed by parents. The levels of FeNO and nNO were measured by NIOX MINO (Aerocrine AB, Solna, Sweden).IBM SPSS statistics 20.0 software was used to analyse the data.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":29283717,"openaccessinfo":{"externalids":{"MAG":"2318074280","ACL":null,"DOI":"10.4172\/2155-6121.1000204","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A sensitive (1\u03c3 rms \u2264 3 mK; 2 MHz resolution) 1 mm spectral survey (214.5\u2013285.5 GHz) of the envelope of the oxygen-rich supergiant star NML Cygni (NML Cyg) has been conducted using the 10 m Submillimeter Telescope of the Arizona Radio Observatory. These data represent the first spectral line survey of NML Cyg and are complementary to a previous 1 mm survey of the envelope of a similar hypergiant, VY Canis Majoris (VY CMa). The complete NML Cyg data set is presented here. In the survey, 104 emission lines were observed, arising from 17 different molecules and 4 unidentified features. Many of the observed features have complex line profiles, arising from asymmetric outflows characteristic of hypergiant stars. While most of the lines in the survey arise from SiO, SO, SO2, and SiS, CO had the strongest emission. Five other C-bearing species are identified in the survey (HCN, CN, HCO+, CS, and HNC), demonstrating an active carbon chemistry despite the O-rich environment. Moreover, NS was observed, but not NO, although favorable transitions of both molecules lie in the surveyed region. Sulfur chemistry appears to be prominent in NML Cyg and plays an important role in the collimated outflows. The refractory species observed, NaCl and AlO, have narrow emission lines, indicating that these molecules do not reach the terminal expansion velocity. NaCl and AlO likely condense into dust grains at r < 50 R *. From NaCl, the chlorine isotope ratio was determined to be 35Cl\/37Cl = 3.85 \u00b1 0.30.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":253249607,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3847\/1538-3881\/ac8df0","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/iopscience.iop.org\/article\/10.3847\/1538-3881\/ac8df0\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We give bounds on the average fidelity achievable by any quantum state estimator, which is arguably the most prominently used figure of merit in quantum state tomography. Moreover, these bounds can be computed online\u2014that is, while the experiment is running. We show numerically that these bounds are quite tight for relevant distributions of density matrices. We also show that the Bayesian mean estimator is ideal in the sense of performing close to the bound without requiring optimization. Our results hold for all finite dimensional quantum systems.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":55673168,"openaccessinfo":{"externalids":{"MAG":"3105284644","ACL":null,"DOI":"10.1088\/1367-2630\/17\/12\/123013","PubMedCentral":null,"ArXiv":"1503.00677"},"license":"CCBY","url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1367-2630\/17\/12\/123013\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Primary hyperparathyroidism is often asymptomatic, may be detected during routine investigations or may present with features of hypercalcaemia. Vitamin D deficiency causing secondary hyperparathyroidism presents with musculoskeletal symptoms. Studies have shown an association between primary hyperparathyroidism and vitamin D deficiency. It has also been observed that when co-exist, these two conditions contribute to each other's disease presentation and severity. This case report depicts initial asymptomatic hyperparathyroidism developing symptoms due to co-existing parathyroid adenoma and vitamin D deficiency in a 26-year-old muslim Bangladeshi female who responded well to adequate pre, per and post parathyroidectomy medical management Birdem Med J 2015; 5(2): 104-106","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":78442530,"openaccessinfo":{"externalids":{"MAG":"2472618066","ACL":null,"DOI":"10.3329\/BIRDEM.V5I2.28389","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This letter considers the problem of multi-agent distributed linear regression in the presence of system noises. In this problem, the system comprises multiple agents wherein each agent locally observes a set of data points, and the agents' goal is to compute a linear model that best fits the collective data points observed by all the agents. We consider a server-based distributed architecture where the agents interact with a common server to solve the problem; however, the server cannot access the agents' data points. We consider a practical scenario wherein the system either has observation noise, i.e., the data points observed by the agents are corrupted, or has process noise, i.e., the computations performed by the server and the agents are corrupted. In noise-free systems, the recently proposed distributed linear regression algorithm, named the Iteratively Pre-conditioned Gradient-descent (IPG) method, has been claimed to converge faster than related methods. In this letter, we study the robustness of the IPG method, against both the observation noise and the process noise. We empirically show that the robustness of the IPG method compares favorably to the state-of-the-art algorithms.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":231709801,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/LCSYS.2020.3045533","PubMedCentral":null,"ArXiv":"2101.10967"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Influenza A viruses circulate in swine and can spread rapidly among swine when housed in close proximity, such as at agricultural fairs. Youth who have close and prolonged contact with influenza\u2010infected swine at agricultural fairs may be at increased risk of acquiring influenza virus infection from swine. Animal and human health officials have issued written measures to minimize influenza transmission at agricultural exhibitions; however, there is little information on the knowledge, attitudes, and practice (KAP) of these measures among animal exhibitors. After an August 2016 outbreak of influenza A(H3N2) variant (\"H3N2v\") virus infections (i.e., humans infected with swine influenza viruses) in Michigan, we surveyed households of animal exhibitors at eight fairs (including one with known H3N2v infections) to assess their KAP related to variant virus infections and their support for prevention measures. Among 170 households interviewed, most (90%, 151\/167) perceived their risk of acquiring influenza from swine to be low or very low. Animal exhibitor households reported high levels of behaviours that put them at increased risk of variant influenza virus infections, including eating or drinking in swine barns (43%, 66\/154) and hugging, kissing or snuggling with swine at agricultural fairs (31%, 48\/157). Among several recommendations, including limiting the duration of swine exhibits and restricting eating and drinking in the animal barns, the only recommendation supported by a majority of households was the presence of prominent hand\u2010washing stations with a person to monitor hand\u2010washing behaviour (76%, 129\/170). This is a unique study of KAP among animal exhibitors and highlights that animal exhibitor households engage in behaviours that could increase their risk of variant virus infections and have low support for currently recommended measures to minimize infection transmission. Further efforts are needed to understand the lack of support for recommended measures and to encourage healthy behaviours at fairs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13783176,"openaccessinfo":{"externalids":{"MAG":"2770199571","ACL":null,"DOI":"10.1111\/zph.12425","PubMedCentral":"6631301","ArXiv":null},"license":"CCBY","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/zph.12425","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"In Canada, there is a paucity of research aimed at understanding Black gay men and the antecedents to risk factors for HIV. This study is an attempt to move beyond risk factor analysis and explore the role of sexual and ethnic communities in the lives of these men. The study utilized a community-based research and critical race theory approach. Semi-structured interviews were conducted with eight key informants to augment our understanding of Black gay men and to facilitate recruitment of participants. In-depth interviews were done with 24 Black gay men. Our data showed that the construction of community for Black gay men is challenged by their social and cultural environment. However, these men use their resilience to navigate gay social networks. Black gay men expressed a sense of abjuration from both gay and Black communities because of homophobia and racism. It is essential for health and social programmers to understand how Black gay men interact with Black and gay communities and the complexities of their interactions in creating outreach educational, preventive and support services.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20310071,"openaccessinfo":{"externalids":{"MAG":"2014398100","ACL":null,"DOI":"10.1080\/13691058.2012.674158","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study aims to assess the active ageing of elderly people aged 60 to 95 years old in Thailand and to investigate its determinants based on the data obtained from the National Statistical Office's elderly survey in 2007. The findings revealed that elderly people in Thailand had moderate active ageing. In terms of each dimension, this found that elderly people had high active ageing under health dimension, moderate active ageing under security dimension, and low active ageing under participation dimension. Additionally, the regression analysis indicated that age and living in urban areas had the negative impacts on the active ageing of elderly people, whereas physical exercise, alcohol consumption, receipt of useful information, awareness of social benefits for elderly people, education, and saving duration had the positive influences on it. The active ageing of elderly people in Thailand was also determined by their most important sources of income. Moreover, the findings revealed that family warmth was positively related to the active ageing of elderly people in Thailand. That is, living with spouse and children under 18 years old and receiving basic needs, visits, and telephone contacts from children helped promote the active ageing of Thai elderly people. However, living with grandchildren and receiving money from children less than 10,000 baht per year were found having the negative relationship with the active ageing of elderly people.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":146726084,"openaccessinfo":{"externalids":{"MAG":"2242242135","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study of thrombocyte parameteres in healthy women in reproductive age (n=29) and pregnant women in third trimester with normal ongoing pregnancy (n=20) and with gestosis (n=38) was conducted. The relative breadth of distribution by volume(PDW, fl), share of cells with volume more than 12 fl (P-LCR, %) and relative quantity of immature thrombocytes (IPF, %) were investigated. It was established that significant decrease of thrombocytes number takes place in pregnants compared to healthy women of reproductive age. The most significant changes were observed in women with moderate and severe gestosis. The reliable increase of relative breadth of thrombocyte distribution by volume in this group of pregnant women was also detected. This may be associated with growth of number of big and, probably, immature and functionally active thrombocytes. Thus, increase in number of immature thrombocytes, occurring in response to endothelium lesions as a part of gestosis pathogenesis, may serve as adaptation marker of thrombopoeisis system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":83193433,"openaccessinfo":{"externalids":{"MAG":"391219073","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Gallstone disease (GSD) is defined as the presence of one or more stones in the gallbladder. Prevalence of GSD in the adult population ranges from 6% to 9% in India. The present study was aimed to know the association of abdominal symptoms and GSD. Patients and Method: We conducted a case-control study from January 2013 to December 2013 among 120 cases and the same number of controls. Study subjects were selected from outpatient department (OPD) of general surgery. Data was collected by a self-designed pretested interview schedule, to assess sociodemographic profile, personal history, medical history, physical examination including anthropometry. Logistic regression was used for univariate and multivariate analysis to find out different symptoms and analyze the independent association of these symptoms with GSD. Results: We enrolled 120 cases and the same number of age and sex matched controls. 69.2% of the cases were females and 30.8% were males. Univariate as well as multivariate logistic regression analysis of presenting symptoms among study subjects showed only intolerance to fatty food (P = 0.000) and epigastric or hypochondric pain (P = 0.000) were found to be statistically significantly associated with gallstone disease. Conclusion: Biliary colic, consisting of sudden onset of pain in the epigastric or right hypochondric region lasting for more than 30 minutes is a good predictor of gallstone disease along with intolerance to fatty or spicy food.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":216589171,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4103\/ais.ais_26_19","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"UNLABELLED\nExercise test variables, such as an impaired heart rate response, are known to be related to left ventricular function and patient prognosis following acute myocardial infarction. The present study was performed to compare exercise test variables in acute myocardial infarct patients following either intravenous thrombolysis or placebo. Symptom-limited bicycle ergometer tests, carried out one to two weeks from the infarction, were performed in 85 patients randomized to intravenous streptokinase (n = 41) or placebo (n = 44) given within 12 hours from onset of symptoms. Resting heart rate, systolic blood pressure and rate-pressure product were similar in the two groups. At maximum workload the streptokinase treated patients had a significantly higher median maximal heart rate than controls (136 vs. 126 min-1; p < 0.01) but only a trend towards higher systolic blood pressure was seen (175 vs. 163 mmHg; p = 0.09). Rate-pressure product at maximal exercise was 23.620 vs. 20.100 mmHg x min-1; p < 0.01). A significantly smaller number of patients in the streptokinase group had exercise capacity below 50 W (0% vs. 15.9%; p < 0.01).\n\n\nIN CONCLUSION\npatients treated with intravenous streptokinase for acute myocardial infarction reach both higher heart rates and rate-pressure products at maximum workload than their controls thus indicating that the beneficial effects of thrombolysis after acute myocardial infarction are reflected in an improved heart rate response during exercise.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25283318,"openaccessinfo":{"externalids":{"MAG":"2415471790","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Citrullus colocynthis-colocynth-Cucurbitaceae, is a widely used plant in traditional medical practice in many disorders, especially for diabetic, stomach pains, cathartic and laxative. Due to the scarcity of scientific reports for its traditional use, we aimed to investigate its effects in high fat (HF) induced hyperlipidemic and streptozotocin(STZ)-induced diabetic rats. Methanolic extract of Citrullus colocynthis (MECC-200 and 400mg\/kg) were administered orally for 30 days. At the end of study, we employed biochemical estimation, which reveals that hyperlipidemic and diabetic groups were shown significant elevation in the level of serum lipid profiles, plasma glucose respectively along with the elevation of serum AST, ALT, lipid peroxides, and this elevation were significantly attenuated by treatment with MECC-200 and MECC-400. In addition, treatment with MECC-200 mg\/kg and MECC-400 mg\/kg were significantly improved the levels of SOD, GSH, CAT in cholesterol fed hyperlipidemic and STZ-induced diabetic rats (**p<0.01). Moreover methanolic extract of Citrullus colocynthis fruits was screened for its free--radical scavenging effect, reducing power and Nitric oxide radical scavenging activity. Results from our study indicates, the definite radical quenching activity of the extract towards DPPH radicals,NO free radicals in comparison with ascorbic acid.In reducing power method, MECC demonstrated dose dependent antioxidant activity comparable with Ascorbic acid.Thus, it clearly indicates that Citrullus colocynthis might be beneficial in attenuating hyperlipidemic and diabetes conditions.Morover the results suggested the ability of the extract to combact oxidative stress by quenching free radicals which revelas that, the atteneuation due to its anti-oxidant property.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90555675,"openaccessinfo":{"externalids":{"MAG":"2729249657","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Most pediatricians have been asked at one time or another to be a consultant or have been the primary care physician asking for a consultation. We or our consultant colleagues, however, often fail to appreciate the subleties inherent in our respective roles. Although communication among physicians, both written and verbal, is essential for optimal patient care, communication between individual physician, parent, and patient not only extends common courtesy but also remains crucial in our present medicolegal climate. How often have we failed to tell a parent that we have asked for a consultant9s opinion or, more embarrassingly, been asked to be the consultant and then walked in on the patient only to discover that no member of the family had ever been told by the patient9s physician who we were or why we were there?","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35763889,"openaccessinfo":{"externalids":{"MAG":"2039275177","ACL":null,"DOI":"10.1542\/PIR.13-4-125","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dopamine (DA) and uric acid (UA) have been found to undergo a protective reaction effecting the fast chemical repair of oxidative free-radical damage to DNA. This antioxidant reaction does not occur with normal concentrations of other, more abundant, antioxidants and our findings suggest that DA and UA are important for the preservation of the DNA in certain brains cells per se. These studies point to the need for drugs that undergo a similar antioxidant reaction with DNA radicals to prevent or arrest DNA damage associated with Parkinson's disease when the levels of DA and UA fall.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43699574,"openaccessinfo":{"externalids":{"MAG":"2168163562","ACL":null,"DOI":"10.1080\/10715760310001604134","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present a consequence-based calculus for concept subsumption and classification in the description logic ALCHOIQ, which extends ALC with role hierarchies, inverse roles, number restrictions, and nominals. By using standard transformations, our calculus extends to SROIQ, which covers all of OWL 2 DL except for datatypes. A key feature of our calculus is its pay-as-you-go behaviour: unlike existing algorithms, our calculus is worst-case optimal for all the well-known proper fragments of ALCHOIQ, albeit not for the full logic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":21654898,"openaccessinfo":{"externalids":{"MAG":"2952190783","ACL":null,"DOI":"10.24963\/ijcai.2018\/272","PubMedCentral":null,"ArXiv":"1805.01396"},"license":null,"url":"https:\/\/www.ijcai.org\/proceedings\/2018\/0272.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The information necessary for assessment of water resources may be obtained by investigating the constituents of water systems: precipitation, runoff, infiltration. The latter two are largely affected by relief: its genesis, lithological structure, relief morphometric indices. The river catchments include relief complexes of variable genesis which differ also in their morphometric indices. This largely determines the surface runoff and infiltration properties of catchment and quantity of groundwater. The surface inclination is one of factors affecting infiltration capacity. In sloping surfaces a considerable amount of precipitation flows down at a high speed. For this reason water infiltration in the upper part of the slope is by far lower than at the foot. Besides, the downstreaming water may accumulate in closed depressions. During rain-falls, it is possible to determine the amount of water, which gets into rivers and other water basins and in groundwater. The energy of running water determines its impact on the slope, i.e. the actual slope erosion. It is determined by water mass and its flowing ratio. As a mass index we may take the largest amount of precipitation which falls down during a rainfall per unit of area. The smallest energy of flowing water, which does erode the slope, equals 0.001 kg\/m2. In all other cases slope erosion takes place. The energy of water flowing down steep slopes is sufficient to start an intensive slope erosion and development of linear forms of erosion. The linear forms of erosion later stimulate a more rapid rain water flow into small river basins and, concomitantly, change the infiltration environment of the basin. The aim of paper \u2013 evaluate of relief dismemberment influence on surface\u2013water infiltration in Salcia and Spengla Rivers catchments and flowing water impact on surface: rivers valley and hill slopes.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":131077278,"openaccessinfo":{"externalids":{"MAG":"2334190255","ACL":null,"DOI":"10.3846\/ENVIRO.2014.075","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We used a retrospective, matching, birth cohort design to evaluate a comprehensive, coalition-led childhood immunization program of outreach, education, and reminders in a Latino, urban community. After we controlled for Latino ethnicity and Medicaid, we found that children enrolled in the program were 53% more likely to be up-to-date (adjusted odds ratio = 1.53; 95% confidence interval = 1.33, 1.75) and to receive timely immunizations than were children in the control group (t = 3.91). The coalition-led, community-based immunization program was effective in improving on-time childhood immunization coverage.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":37340494,"openaccessinfo":{"externalids":{"MAG":"2068739786","ACL":null,"DOI":"10.2105\/AJPH.2007.121046","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper attempts to define a culture-specific communicative style which I call communicative ethno-style and determine the factors which lead to its formation. While defining communicative ethno-style some generalizations are unavoidable and reference is made to a typical user of standard language and his\/her communicative behaviour in interpersonal interaction in everyday situations. At the same time it is not possible to take a dichotomous approach in describing the communicative styles as they form a continuum and need to be viewed in comparison. In this paper I demarcate the dominant features of Russian communicative style as opposed to British and emphasize the importance of a systemized description of culture specific communicative differences through communicative ethno-styles. This is important for developing pragmatic and discourse competence necessary for intercultural communication. The study is based on empirical data obtained through questionnaires, interviews and observations and follows contextual, pragmatic, discourse analyses. The theoretical framework is based on Politeness Theory (Brown and Levinson, 1987; Leech, 1983, 2005; Watts, 2003), Speech Act Theory (Austin, 1962; Searle, 1969) and the Theory of Cultural Scripts (Wierzbicka, 1991\/2003, 2002, 2006).","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":142435769,"openaccessinfo":{"externalids":{"MAG":"1465430642","ACL":null,"DOI":"10.1163\/18773109-00702003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This Master's Thesis contributes with a rich description of normative control as a social process, through the illustration and interpretation of the practical efforts and sense-making that surround it. These contributions are made possible through an ethnographic case study at a medium-sized, fast-growing dotcom company with a distinct and salient corporate culture and normative control efforts. The mystery, however, is how the company exercises control and keeps its staff happy while most of them are performing tedious and repetitive work tasks. By applying a dramaturgical framing device, we illustrate how the staff engages in a performance involving the creation of an organizational anti-identity. This enables the company to emerge as a saviour, which justifies and legitimizes control efforts, in turn resulting in grateful and loyal employees who accept repetitive work tasks as part of their obligation. Additionally, we show how the concept of neo-normative control\u2014rather than providing 'existential empowerment'\u2014enables normative control efforts to take a firmer grip on the individuals' identity (Fleming & Sturdy, 2009). In conclusion, we show how corporate culture, normative control efforts, and organizational identity work can be observed to create a continuous loop of socialization, justification, legitimization, and institutionalization (c.f. Berger & Luckmann, 1966).","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":149316063,"openaccessinfo":{"externalids":{"MAG":"2721793587","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The characterization of binary communication channels using functions of finite-state Markov chains is considered. Two distributions which are relevant to code evaluation, i.e., the error-free run and error-cluster distributions, are derived. It is shown for an N -state model, partitioned into a group of k error-free states and N-k error states, that the general form of the error-free run distribution is the weighted sum of at most k exponentials, and that of the error-cluster distribution the weighted sum of at most N-k exponentials. As evidence of the capability of such models to characterize real communication channels, a simple class of models is investigated and shown experimentally to be capable of representing HF radio statistics.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":43362907,"openaccessinfo":{"externalids":{"MAG":"2101602277","ACL":null,"DOI":"10.1109\/TIT.1967.1053975","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"From September 1988 to April 1989, 400 patients with stones in the calyx (40%), in the renal pelvis (45%), in the ureter (15%) and with staghorn calculi (5%) underwent shock wave treatment. In the majority of patients therapy was carried out with general anesthesia. Disintegration was achieves in 95% of stones in the kidney and 44% of stones localized in the ureter following \"in situ\" ESWL. The ureteroscopy and stone push-up with replacement into the renal ampulla was performed in 56% of ureteral calculi. The average number of impulses to achieve disintegration was 1850. In 20 patients were necessary 4000 SW; we studied this patients with echography, TAC and RMN 48 hours after the treatment. The objective of this trial is the assessment of the efficacy and cost benefit relation of lithotripter TRIPTER X1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31644811,"openaccessinfo":{"externalids":{"MAG":"2426851091","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article considers research conducted on the impact of the Crown's treaty claims settlement policy on M\u0101ori in New Zealand. It provides a brief background to the Treaty of Waitangi and the subsequent British colonisation process that relied on the Doctrine of Discovery in breach of the treaty. It outlines how colonisation dispossessed M\u0101ori of 95 percent of their lands and resources, usurped M\u0101ori power and authority and left them in a state of poverty, deprivation and marginalisation while procuring considerable wealth, prosperity and privilege for British settlers. The work of the Waitangi Tribunal, the commission of inquiry set up to investigate those breaches, is considered, as is the Crown's reaction to the 1987 Lands case in developing its treaty claims settlement policy. The Crown unilaterally imposed the policy despite vehement opposition from M\u0101ori. Since 1992, it has legislated more than seventy 'settlements'. The research shows that overall, the process has traumatised claimants, divided their communities, and returned on average less than one percent of their stolen lands. Proposals for constitutional transformation have drawn widespread support from M\u0101ori as a solution to British colonisation. United Nations treaty-monitoring bodies have recommended that the government discuss this with M\u0101ori.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":211389910,"openaccessinfo":{"externalids":{"MAG":"2981278831","ACL":null,"DOI":"10.3390\/land8100152","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-445X\/8\/10\/152\/pdf?version=1571824382","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo examine the contribution of employment status, welfare benefits, alcohol use, and other individual and contextual factors to physical aggression during marital conflict.\n\n\nMETHODS\nLogistic regression models were used to analyze panel data collected in the National Survey of Families and Households in 1987 and 1992. A total of 4,780 married or cohabiting persons reinterviewed in 1992 were included in the analysis. Domestic violence was defined as reporting that both partners were physically violent during arguments.\n\n\nRESULTS\nUnemployed respondents are not at greater risk of family violence than employed respondents, after alcohol misuse, income, education, age, and other factors are controlled for; however, employed persons receiving welfare benefits are at significantly higher risk. Alcohol misuse, which remains a predictor of violence even after other factors are controlled for, increases the risk of family violence, and satisfaction with social support from family and friends is associated with its decrease.\n\n\nCONCLUSIONS\nAlcohol misuse has an important effect on domestic violence, and the potential impact of welfare reform on domestic violence needs to be monitored.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9900659,"openaccessinfo":{"externalids":{"MAG":"1978097433","ACL":null,"DOI":"10.1136\/EWJM.174.5.317","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In recent years, the monitoring of sitting postures was discovered to be a promising measure of healthy sitting behavior, comfort, physical wellness and emotions. Most state-of-the-art systems for monitoring sitting behavior are based on supervised methods that are limited to a fixed set of classes. We present a method that does not rely on training but distinguishes between different postures autonomously. We designed and implemented a system to monitor sitting behavior in an unsupervised manner. Based on the pressure distribution acquired from a pressure mat we generate prototypes of sitting postures. The prototypes are stored in a database and serve as reference for comparing and classifying incoming pressure data. The system relies on only a few, interpretable system parameters and performs in real-time. We conducted an experiment with a collective of 8 subjects and recorded the data of 16 different postures for each subject. Our proposed method generates on average 15.57 prototypes of postures. This reflects well the 16 postures that actually occurred in the experiment. In 91% of all cases an unambiguous assignment of a posture to exactly one generated prototype was achieved. On the other hand an unambiguous assignment of a prototype to a posture was obtained in 86%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22147470,"openaccessinfo":{"externalids":{"MAG":"2165314868","ACL":null,"DOI":"10.1109\/IEMBS.2009.5334620","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In a one-variable, finite size reaction\u2013diffusion system, the existence of a minimal domain size required for the existence of a non-zero steady state is predicted, provided that the reaction\u2013diffusion variable has a fixed value of zero at the boundaries of the domain (Dirichlet boundary conditions). This type of reaction diffusion model can be applied in population biology, in which the finite domain of the system represents a refuge where individuals can live normally immersed in a desert, or region where the conditions are so unfavourable that individuals cannot live in it. Building on a suggestion by Kenkre and Kuperman, and using non-chemotactic E. coli populations and a quasi-one-dimensional experimental design, we were able to find a minimal size (approximately 0.8\u200acm) for a refuge immersed in a region irradiated with intense UV light. The observed minimal size is in reasonable agreement with theory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12949135,"openaccessinfo":{"externalids":{"MAG":"1984455901","ACL":null,"DOI":"10.1098\/rsif.2005.0054","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1578274?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We apply the guiding center theory and show that the larger dispersion variation leads the larger peak power in a pulse and the reduced nonlinear interaction between pulses. The nonlinear interaction between pulses can be understood through the soliton property of the core. This shows that the nonlinear interactions between pulses is reduced when the dispersion variation of fibers increases with a fixed pulse width.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":113984282,"openaccessinfo":{"externalids":{"MAG":"2479433738","ACL":null,"DOI":"10.1049\/EL:19970715","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The clearance function of complement receptors on Kupffer cells is depressed after several forms of experimental injury. In vitro studies have shown that stimulation of beta-receptors on macrophages causes a depression of several aspects of macrophage function. The present study evaluated the possibility that the increase in sympathetic activity associated with injury contributes to the depression of Kupffer cell complement receptor function. Complement receptor function was assessed in rats from the hepatic uptake of rat erythrocytes coated with IgM. Isoproterenol caused a depression of receptor function when infused at a rate of 5.0 and 0.5 micrograms\/kg\/min for 15 min but not after infusion of 0.05 micrograms\/kg\/min. Infusion of isoproterenol, norepinephrine, and epinephrine at 0.5 micrograms\/kg\/min depressed receptor function by 41%, 38%, and 29%, respectively. Beta-receptor blockade with propranolol prevented the depression of receptor function caused by isoproterenol and norepinephrine. Thermal injury depressed receptor function by 65%, and this depression was reduced to 35% by beta-receptor blockade. Therefore, stimulation of beta-receptors on macrophages by increased circulating levels of catecholamines after injury could contribute to the depression of Kupffer cell function caused by injury.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42778482,"openaccessinfo":{"externalids":{"MAG":"156238600","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose The purpose of this study was to examine the perceived self-efficacy of the clinical nurse specialist working in the United States during the COVID-19 pandemic and explore whether there was any difference in self-efficacy based on practice focus (spheres of impact) and if differences existed between self-efficacy and demographics. Design This study used a nonexperimental, correlational, cross-sectional design utilizing a voluntary, anonymous, 1-time survey administered through Qualtrics (Qualtrics, Provo, UT). Methods The National Association of Clinical Nurse Specialists and 9 state affiliates distributed the electronic survey starting late October 2021 through January 2022. Survey content consisted of demographics and the General Self-efficacy Scale, which measures the individual's perceived ability to cope and execute tasks when faced with hardship or adversity. Sample size was 105. Results Results included a high perception of self-efficacy of the clinical nurse specialist working during the pandemic, no statistical significance in practice focus, and a statistically significant difference in the scores of self-efficacy for participants with previous infectious disease experience compared with those without experience. Conclusions Clinical nurse specialists with previous infectious disease experience can guide policy, be utilized in multifaceted roles to support future infectious disease outbreaks, and develop training to prepare and support clinicians during crises such as pandemics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259170460,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/NUR.0000000000000753","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Route planning and guidance (RPG) services are intended to provide benefits to their users, in the form of either convenience or, more importantly, travel time savings. The reduction in system travel time, if achieved, is a \"side effect.\" How should the transportation management agency then respond to these services? Under what circumstances should the agency encourage or discourage their implementation? A model to answer these questions is developed. Two ingredients are important in the model discussed. First, the market penetration of RPG is modeled in an elastic manner. Analogous to a supply-demand equilibrium, market penetration is determined endogenously in an equilibrium between the benefits and cost of acquiring the services. It is argued that the cost of RPG services could be used as a way to alter the elastic market penetration, and hence modify and, it is hoped, lower the total system congestion. Thus, a bilevel program to capture the situation is formulated. The lower-level program models the multiclass (equipped and unequipped) equilibrium problem with elastic market penetration. The upper-level program then minimizes the system travel time by using the cost of RPG services as a control variable. Numerical results of a small network are provided to illustrate the behavior of this model.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":109019096,"openaccessinfo":{"externalids":{"MAG":"2016384164","ACL":null,"DOI":"10.3141\/1667-04","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Atresia ani is a congenital defect describes absence of a normal anal opening. It is fatal unless surgical correction is carried out to provide anal opening. In female, the rectum may break through vagina forming a rectovaginal fistula permitting defecation via the vulva. Surgical treatment of atresia ani is indicated to save the animal life and to improve body weight gain. Ten kids and eight lambs suffering from atresia ani referred to the veterinary health center at the Jordan University of Science and Technology in the period of 2004-2009 suffering from atresia ani. Clinical examination and ultrasonography confirmed atresia ani without any other intestinal congenital deformities. Affected animals were subjected to surgical anal reconstruction following animal casting, site preparation and analgesia. A circular perineal skin tissue was excised to explore the pelvic cavity associated with blunt dissection of the perineal region exposing the blind cull- de- sac of the rectum. The blind rectum segment was opened and the meconium was evacuated. Full thickness rectum and was secured using simple interrupted stiches. Anal reconstruction proved successfully for all treated kids and lambs. The new stoma provides a permanent patent orifice for normal passage of feces until the age of slaughter. This surgery was legitimate, considering the high incidence of atresia ani, simple, economic, and lifesaving surgical technique. Anal reconstruction in affected animal is an obligatory surgery rather than alternative euthanasia. Anal reconstruction increases body weight gain and decreases the economic loss in the small ruminant herd industry due to atresia ani.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":39790943,"openaccessinfo":{"externalids":{"MAG":"2082960342","ACL":null,"DOI":"10.12816\/0001102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction: Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India, with high prevalence rates found in North Gujarat. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not been widely investigated with respect to the serum lipid levels. The changes in lipid profile have long been associated with cancer as lipids play a key role in the maintenance of cell integrity. Aim: To investigate the alterations and clinical significance of serum lipid profiles in OSMF patients. Materials and Methods: A total of 50 subjects were included in the study and divided into two groups. Group I consisted of 40 clinically diagnosed OSMF subjects and group II consisted of 10 healthy subjects. After taking a thorough history, clinical examination, and informed consent, all the patients were sent for lipid profile estimation, which consisted of (i) serum total cholesterol (TC), (ii) low density lipoprotein (LDL) cholesterol, (iii) high density lipoprotein (HDL) cholesterol, (iv) very low density lipoprotein (VLDL) cholesterol, and (v) serum triglycerides (TG). Results: The serum lipid levels were significantly lower in patients with OSMF than in the controls, which was most evident in stage IV OSMF. From the present results, it is evident that the level of serum lipids decreases with the progression of the disease. Conclusion: This study suggests that decrease in lipid levels may be considered as a useful marker in the early diagnosis of oral premalignant conditions like OSMF.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78716742,"openaccessinfo":{"externalids":{"MAG":"2512869052","ACL":null,"DOI":"10.4103\/0972-1363.188751","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/0972-1363.188751","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This study analyzed the effects of an exercise training program consisting of a knee joint complex exercise device (leg-link system) with digitally controlled active motion function and squat movement on physical fitness and gait ability of elderly women aged 70 or above. Fifty four (54) elderly women aged 70 or above were divided into three groups as control group (n = 18), aerobic training group (n = 18), and combined training group with resistance and aerobic exercise (n = 18). Health-related physical fitness, gait ability-related physical fitness, and the temporal and spatial parameters of gait ability were compared. The health-related physical fitness after the 12-week training was not significantly altered in control group, whereas combined training group showed significant increase in all factors (p < 0.05) and aerobic training group showed significant increase (p < 0.05) only in the physical efficiency index. The gait ability-related physical fitness and all items of the temporal and spatial parameters of gait were found to have significantly increased (p < 0.05) in combined training group after the 12-week exercise training; however, in aerobic training group, only the factors related to muscular endurance and balance showed significant increase (p < 0.05). This study suggested that the exercise training consisting of knee joint complex exercise with digitally controlled active motion function and squat exercise for strengthening lower extremities and core muscles had positive effects on enhancing the ambulatory competence in elderly women.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231865077,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ijerph18041515","PubMedCentral":"7915473","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/1515\/pdf?version=1634623160","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose: Cytomegalovirus (CMV) is a worldwide distributed pathogen that may cause serious complications in patients with hematological diseases. This study aimed to serologically characterize the CMV infection in patients suffering from hematological diseases in Amazonas, Brazil.\nMethods: Serum samples from 323 patients were tested for the presence of anti-CMV IgM or IgG antibodies by an enzyme-linked immunosorbent assay. Positive samples for IgM were submitted to the IgG avidity test to differentiate primary infection from recurrent infection. An epidemiological questionnaire was administered to collect sociodemographic information of the study population.\nResults: The overall prevalence of CMV infection verified in this study was 91.3%. The highest rates were found in patients suffering from platelet disorders (94.5%), anemia (93.3%), or leukemia (91%). The study population was predominantly composed of individuals with low socioeconomic status. Blood transfusions were more often in patients with anemia or leukemia, but it was not correlated with the positivity for CMV infection. Measurement of IgG avidity in patients positive for anti-CMV IgM demonstrated a recurrent infection rate of 5.2% (17\/323). Over 80% of recurrent infection occurred in patients with acute lymphocytic leukemia (ALL) or anemia.\nConclusions: Our findings indicated that CMV infection is highly prevalent in patients with hematological diseases from the Brazilian western Amazon. The prevalence observed progressively rose with increasing age, whereas anemia or ALL disease figured as risk factors for the recurrence of CMV infection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":233924910,"openaccessinfo":{"externalids":{"MAG":"3131698803","ACL":null,"DOI":"10.21203\/RS.3.RS-231928\/V1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract In the present work, sixteen different zinc porphyrins (possessing different meso\u2005substituents) with and without a chiral guest were modelled using DFT and TD\u2010DFT approaches in order to understand the influence of various controlling factors on electronic circular dichroism (ECD) spectra. Two major aspects are influenced by these factors: excitation energy of the electronic transitions and their intensity. In the case of excitation energy, the influence increases in the following order: orientation of the peripheral substituents 0 self-focusing medium. It is shown that for sufficiently small d\/\u03bb (\u03bb is the wavelength) the nonlinear wave may exist only at power flows exceeding some certain minimal value. For sufficiently large d\/\u03bb we have found bistable states of s-polarized nonlinear waves provided that the total power flow is the control parameter and for power flows exceeding some certain threshold value a single waveguide mode (with mode order m = 0) occurs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121085178,"openaccessinfo":{"externalids":{"MAG":"2048963506","ACL":null,"DOI":"10.1088\/0031-8949\/30\/5\/008","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study was accomplished for the purpose of developing a textile processing ingredient that is harmless to the human body and environment. The research method consists of dyeing cotton textiles by extracting the dye solution from ginseng. Then, chrominance, after treatment, antibacterial ratio and deodorization ratio of cotton fabrics dyed with ginseng extracts were tested and results were examined. The research procedure involved first extracting the dye solution from the ginseng`s by-product (fine roots) and then dyeing was effectuated differently according to the test samples temperature and dyeing time requirements. Brightness in all dye substances was lower in pre-mordanting. Beige color could be extracted from pre-mordanted samples. And dark orange from post-mordanted samples. Color-festness was high in all samples. Most of samples show a big antibacterial ratio and deodorization ratio. Through this research it has been discovered that, when applied to textiles, Korea`s ginseng extract possessed reproducibility features as a natural dye and a possibility to be used in cutting which plays a crucial role in hygienic processing. In addition, by using ginseng`s by-product for dyeing processing as the dye solution, efficient application of resources and occurrences of no water waste damages were demonstrated and thus, proved to be environmentally-friendly. Specifically, through this experiment, it was found that saponin, ginseng`s special characteristics, possessed excellent antibacterial odor repelling functions to clothing as well as the capability to prevent skin disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":227555759,"openaccessinfo":{"externalids":{"MAG":"101350642","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this work, multipartite entanglement is classified by polynomials. I show that the operator size is closely related to the entanglement structure. Given a generic quantum state, I define a series of subspaces generated by operators of different sizes acting on it. The information about the entanglement is encoded into these subspaces. With the dimension of these subspaces as coefficients, I define a polynomial which I call the entanglement polynomial. The entanglement polynomial induces a homomorphism from quantum states to polynomials. It implies that we can characterize and find the building blocks of entanglement by polynomial factorization. Two states share the same entanglement polynomial if they are equivalent under the stochastic local operations and classical communication. To calculate the entanglement polynomial practically, I construct a series of states, called renormalized states, whose ranks are related to the coefficients of the entanglement polynomial.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":247594357,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21468\/scipostphyscore.6.3.063","PubMedCentral":null,"ArXiv":"2111.07636"},"license":"CCBY","url":"https:\/\/scipost.org\/10.21468\/SciPostPhysCore.6.3.063\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Characterization of nuclear waste packages is crucial to optimize waste management (temporary storage, transport, final repository). Passive and active non-destructive methods are well-adapted to this problem and their coupling can be extremely useful in order to optimize data analysis. Photon activation analysis (PAA), based on the photofission process and on the detection of delayed particles emitted after this reaction, is a powerful tool for the analysis of bulky concrete waste packages. Methods developed around PAA allow to locate, identify and quantify the mass of actinides (235U, 238 U, 239Pu) present in a given package in order to estimate its alpha activity. In this article, we present experimental and simulated results obtained in PAA during the characterization of a real nuclear waste package in the SAPHIR facility (Active Photon and Irradiation System). For the first time, several non-destructive methods (passive gamma-ray spectrometry, high-energy radiography) are combined with traditional PAA techniques (altitude scan, global photofission, photofission tomography) in order to optimize the characterization process.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":14062375,"openaccessinfo":{"externalids":{"MAG":"2901618185","ACL":null,"DOI":"10.1109\/TNS.2010.2087356","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Decision-making in the field of healthcare is a very complex activity. Several tools have been developed to support the decision-making process. DMN, a modeling technique focused on decisions, is among these and has been gaining prominence in both, literature and business, as has the multi-criteria method PROMETHEE II that helps decision-makers with multi-criteria in analyses. Thus, this research targets combining these two techniques and analyzing the decision support that these two tools afford together. The diagnostic stage of stroke patients was used to perform this work. The research demonstrated that this proposal can drive major gains in efficiency and assertiveness in decision-making in time-sensitive hospital processes. After all, there is a noticeable dearth of hospitals with specialized teams as well as a shortfall of adequate infrastructure for this treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249464719,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3233\/SHTI220088","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors show that integrity protection as a technical means towards automated teller machine (ATM) security is not enough to establish trust towards ATM users. The attacks, aiming at getting into possession of users' bank card details and personal identification numbers (PINs) are manifold. The authors come up with a solution that allows users to establish trust into the ATM integrity protection being in place. The users' mobile phones play a central role in the trust establishment. The authors also shift the PIN entry away from the possibly insecure ATM's PIN pad towards the users' mobile phones.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6561245,"openaccessinfo":{"externalids":{"MAG":"1971428892","ACL":null,"DOI":"10.1049\/iet-ifs.2012.0220","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Eleven of 89 dogs (12 per cent) developed neurological signs within six days of surgical attenuation of a congenital extrahepatic portosystemic shunt. Neurological signs were not associated with hepatic encephalopathy or hypoglycaemia. Signs varied in severity from non-progressive ataxia (three dogs) to generalised motor seizures (four dogs), progressing to status epilepticus (three dogs). In a further four cases, ataxia and disorientation were treated vigorously with anticonvulsant medication, presumably preventing the development of seizures. Two dogs that developed status epilepticus died or were eventually euthanased. All other animals survived, although some had persistent neurological deficits. Postligation neurological complications were not prevented by gradual shunt attenuation. Prophylactic treatment with phenobarbitone (5 to 10 mg\/kg preoperatively, followed by 3 to 5 mg\/kg every 12 hours for three weeks) did not significantly reduce the incidence of neurological sequelae (2\/31 [6 per cent] dogs with phenobarbitone vs 9\/58 [16 per cent] without phenobarbitone; P = 0.2). However, no animal receiving phenobarbitone experienced generalised motor seizures or status epilepticus. In conclusion, these observations suggest that postligation neurological syndrome comprises a spectrum of neurological signs of variable severity. Perioperative treatment with phenobarbitone may not reduce the risk of neurological sequelae, but may reduce their severity.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":13346533,"openaccessinfo":{"externalids":{"MAG":"2044075489","ACL":null,"DOI":"10.1111\/J.1748-5827.2000.TB03150.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Diabetes mellitus is a metabolic disease characterized by hyperglycemia that occurs due to defects in insulin secretion, insulin action or both. Half-life is very important, especially in long-term treatment in order to achieve therapeutic success. As in the Hadith narrated by Muslim. That every disease has a cure. Then the drugs used obediently will help the patient's condition get better. In the management of the disease, the role of the patient becomes very important, especially in terms of increasing adherence to therapy in order to achieve optimal blood glucose levels to prevent more severe complications. The purpose of this study was to describe the level of treatment of patients with diabetes mellitus prolanis at\u00a0 Jatisari Clinic in the period from January to April 2021. The type of research conducted an observational study using a descriptive method. Sampling using a total sampling technique with a sample of 99 patients. The primary data collection instrument used a Morisky Medication Adherence Scale 8 items (MMAA-8) questionnaire find the level of adherence therapy in Diabetes Mellitus patients. The results of the study found that the level of adherence to treatment in patients with diabetes mellitus prolanis at\u00a0 Jatisari Clinic according are \"High Adherence\" , \"Medium Adherence\", and \" Low Adherence\" with 33 patients (33.33%) , 43 patients (43.44%)\u00a0 and 23 patients (23.22%) respect ively","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":252373325,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.46799\/jhs.v2i12.370","PubMedCentral":null,"ArXiv":null},"license":"CCBYSA","url":"https:\/\/doi.org\/10.46799\/jhs.v2i12.370","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The long-time behavior of the velocity autocorrelation function (VAF), for hard disk and sphere systems, has been extensively explored. Its behavior for systems interacting via a soft repulsive or attractive potential is less well known. We explore the conditions under which the nonexponential, long-time tail in the velocity autocorrelation function of a tagged atom, in soft-repulsive sphere (Weeks-Chandler-Andersen) and Lennard-Jones atomic fluids, may be readily observed by the molecular dynamics method. The effect of changing the system size, the fluid density, the form of the interatomic force and the mass of the tagged atoms are investigated. We were able to observe this long-time tail only for systems of moderate density. At low density the effect, if it exists, is at longer times than we can currently simulate owing to limitations of system size and at higher densities these tails were not observed possibly due to other effects dominating the behavior of the VAF and masking this behavior. Under the physical conditions that are simulated here attractive forces have very little effect on the behavior of the VAF. However, as the mass of the tagged particles is increased the time at which the long-time tail commences is lengthened and its magnitude is significantly increased. This later effect suggests that by increasing the mass of the tagged particles one may be able to study more readily the behavior, nature and physical origin of long-time behavior of the VAF both by computational and by experimental techniques.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41123969,"openaccessinfo":{"externalids":{"MAG":"2067332569","ACL":null,"DOI":"10.1103\/PHYSREVE.63.026109","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose\nThe purpose of this paper is to examine the effects of past entrepreneurial experience on the reported innovativeness of serial entrepreneurs' subsequent ventures.\n\n\nDesign\/methodology\/approach\nBuilding on insights from the generative entrepreneurial learning process and from cognition theories, the authors propose that regardless of the type of entrepreneurial experience, positive or negative, such experience enriches the cognitive schemas of serial entrepreneurs leading them to greater reported innovativeness. The proposed hypotheses are tested on a unique sample drawn from a Catalan adult population survey.\n\n\nFindings\nResults reveal that practical experience is an essential prerequisite for entrepreneurial learning, and even negative entrepreneurial experience may induce generative entrepreneurial learning suitable for subsequent outperforming ventures for the psychologically strong who have managed to learn from their experience.\n\n\nPractical implications\nThe importance of this study stretches beyond a purely academic discussion and has implications for policy making within the area of business and economic development. Appropriate policy depends on the likeliness for serial entrepreneurs to improve. Thus, if serial entrepreneurs learn from their venturing experiences and\/or acquire valuable knowledge from them, they may perform better, on average, in subsequent ventures. If subsequent ventures do build upon prior entrepreneurial experiences, calls for policy to encourage re-entries by entrepreneurs may be warranted, even if those entrepreneurs performed poorly in their previous ventures.\n\n\nOriginality\/value\nThe authors analyze the impact of past performance of serial entrepreneurs on the reported innovativeness of their subsequence ventures. The contributions of this study stand as: the inclusion of the re-entry decision together with the innovativeness decision of entrepreneurs within the same model; separation of the positive or negative nature of serial entrepreneurs' past experiences; focus on the entrepreneur rather than the firm as a unit of analysis; the use of a unique primary data set specifically collected for the purpose of this study about the past entrepreneurial experience of the Catalan adult population.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":158504928,"openaccessinfo":{"externalids":{"MAG":"2903405433","ACL":null,"DOI":"10.1108\/MD-06-2017-0592","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: OHQoL is crucial for the best preoperative assessment and development of suitable indications for mandibular third molar surgical extraction. The current study hopes to report QoL after surgical extraction of impacted mandibular third molars. Materials and Methods: This was a prospective study conducted in the Department of Oral and Maxillofacial Surgery, between January 2020 and April 2020. After consenting to partake in the study, patients' baseline demographics, indication for seeking third molar removal and laterality of impaction were recorded. All the surgical extractions were performed by the same surgeon. Pain was assessed pre and postoperatively with the numerical pain rating scale while QoL was assessed pre and postoperatively using the validated Arabic version of the 16 item United Kingdom Oral Health Related Quality of Life measure (UK-OHQoL). Results: A total of 92 patients were recruited. There are 41 (44.6%) males and 51 (55.4%) females with M:F of 1:1.2. Age range was between 18 and 48 years with a mean of (31.2\u2009\u00b1\u20096.6) years. Age group 20\u201329 years constitutes the highest number of patients. Subscales: eating, appearance, sleep, mood and work revealed more percentage complaints (42.9%, 23.4%, 24.7%, 28.6%, and 16.9%, respectively). Regarding mean domain and overall QoL scores, it was observed that there was gradual improvement in mean scores from the Pre-op values and the review periods with best mean QoL reported at POD 14Conclusion: Improvement in overall mean QoL scores during the review periods as compared with the preoperative score was observed. Eating, appearance, sleep, mood and work subscales revealed more percentage complaints.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251177179,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4103\/jwas.jwas_12_22","PubMedCentral":"9516752","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9516752","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"During the last twenty years, more than 150 documents in Bactrian, the language of pre-Islamic Afghanistan, have come to light. These documents, which have been deciphered and published by Nicholas Sims-Williams, provide unique information on the history of Afghanistan and neighbouring lands in the 4th to 8th centuries C.E., as well as revealing a Middle Iranian language which was hardly known before. The purpose of the present volume is to illustrate the new documents as comprehensively as possible. In addition to 230 pages of photographs, the volume contains a complete catalogue of the documents.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128275246,"openaccessinfo":{"externalids":{"MAG":"594982769","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The English has been widely used and expanded with the globalization of the business world, notably ESP is considered a part of it. This study aims to seek out the challenges of teaching and learning Business English in Ukrainian universities. Considerable experience as Business English teachers at several Ukrainian universities and ongoing contact with colleagues in the professional community of ESP teachers, provides an opportunity to affirm that the results we found in the empirical study are typical for most Ukrainian universities. This assumption was also supported in the discussions with the ESP teachers from different regions of Ukraine during the British Council's \"English for Universities\" project (2015-2018). Data collection was done by conducting a questionnaire survey for the ESP practitioners that had the issues in teaching ESP course at the Faculty of Economics, Taras Shevchenko National University of Kyiv The findings revealed the challenges that ESP practitioners face, particularly: difference in students' language competence, course content selection, lack of motivation, in-class hours etc. and possible solutions in overcoming the constraints in teaching. The study suggests that Business English practitioners should develop and improve practical tools for evaluation and certification of results following the requirements and further improvements should be implemented in the methodology and organization of ESP teaching, the content of the course, the course design, the development of course-books and supplementary teaching materials for each specialty.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":228846181,"openaccessinfo":{"externalids":{"MAG":"3166288571","ACL":null,"DOI":"10.24093\/awej\/elt3.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/awej.org\/images\/AllIssues\/Specialissues\/SpecialIssueonheEnglishLanguagenraqiContext2020\/SpecialIssueonheEnglishLanguageonUkraineContext2020\/6.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This thesis is conducted in the context of the hotel industry. Every year, the hotel investigated in this thesis completes a job satisfaction survey. The survey is built upon several facets from which an overall job satisfaction is derived. The problem is that the survey has through time shown poor results, especially with facets concerning management. When those facets were summed up with other facets, it had a strong negative influence on the overall job satisfaction at Hotel X. Scarpello and Campbell (1983) argue that all facets may not directly influence overall job satisfaction, and as a consequence the sum of several facets might contribute to misleading conclusions.The purpose of this thesis is to investigate how managerial processes influence employees' overall job satisfaction at Hotel X. By managerial processes is meant what managers do or is perceived by employees to do. The thesis investigates job satisfaction at both an overall and a facet level. Questions on which facets that influence overall job satisfaction, as well as whether managerial processes have a direct or indirect influence on overall job satisfac-tion are answered.In order to fulfil our purpose multiple sources of evidence were used. Surveys made by the hotel were used as secondary data. The primary data consisted of qualitative observations and indepth interviews with employees. The facets investigated were; Job Contents, Equip-ment, Salary, Rewards, Benefits, Conditions of Employment, Personal Development, Co-workers, Immediate Management and Top Management. The managerial processes dealt with were organisational structure, managerial style and communication.The company survey of 2005 and the results from qualitative data corresponded well. Job Contents, Conditions of Employment, Personal Development, Co-workers, Immediate Management and Top Management all influenced overall job satisfaction. However, there were no indications found that Equipment, Salary, Rewards and Benefits influenced overall job satisfaction. Managerial processes were significant for all facets, except for Salary. Top Management and Immediate Management were the only facets with a direct connection between managerial processes and overall job satisfaction. Communication was found to be the process which influence job satisfaction the most. It turned out to influence all the facets that were either directly or in-directly linked to overall job satisfaction.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":167183137,"openaccessinfo":{"externalids":{"MAG":"594525045","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper uses an unusual pay reform to test the responsiveness of investment in schooling to changes in redistribution schemes that increase the rate of return to education. We exploit an episode where different Israeli kibbutzim shifted from equal sharing to productivity-based wages in different years and find that students in kibbutzim that reformed earlier invested more in education. This effect is stronger for males and is mainly driven by students whose parents have lower levels of education. Our findings support the prediction that education is highly responsive to changes in the redistribution policy, especially for students from weaker backgrounds.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212430221,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3386\/w17093","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.3386\/w17093","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Wavelet Packet based Multi-Carrier Modulation (WPMCM) offers an alternative to the well-established OFDM as an efficient multicarrier modulation technique. It has strong advantage of being a generic transmission scheme whose actual characteristics can be widely customized to fulfill several requirements and constraints of an advanced communication systems. However, a few research questions remain to be addressed before the novel WPMCM can be used in practice. One of the major concerns is the performance of WPMCM transceivers in the presence of analogue radio frequency front-end imperfections. In this paper we analyze the impact of interference in WPMCM transmission caused by the carrier frequency offset and phase noise. The sensitivity of WPMCM transceivers to these errors using standard wavelets is evaluated through simulation studies and their performances are compared and contrasted with OFDM.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2981318,"openaccessinfo":{"externalids":{"MAG":"2114692212","ACL":null,"DOI":"10.4304\/jcm.4.7.496-508","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A microelectromechanical systems analog tunable capacitor has been designed and fabricated for implementation into a two-pole UHF filter. Recent developments on the capacitor have improved the RF device performance significantly, and have resulted in improved UHF filter performance. In the 225-400-MHz range that this device is intended for, Q values are in excess of 100. In addition, an 8.4 : 1 tuning ratio has been achieved with continuous tuning over a 1.4 : 11.9-pF range. When implemented into a two-pole UHF filter, tuning over the entire 225-400-MHz range was achieved with a loss under 6.2 dB.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1,"unknown":2}},"corpusid":110918468,"openaccessinfo":{"externalids":{"MAG":"2134295712","ACL":null,"DOI":"10.1109\/TMTT.2002.806519","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To maintain gut homeostasis intestinal stem cells (ISCs) constantly replace damaged ones. This process is conservative from Drosophila to human. Proliferation and differentiation of ISCs in adult Drosophila midgut are regulated by growth factors which are secreted in the surrounding cells collectively forming ISCs niche. Here I discuss an interaction between ISCs with its niche through conservative signaling pathways. Several evidences on significance of cooperation between multiple signaling pathways including Notch, Wingless, JAK\/STAT, EGFR, Hippo, and insulin signaling for regulation of stem cell maintenance and activity are provided. Further investigation in this area will allow us to understand how proper regulation of ISCs maintenance and differentiation can assist to ensure intestinal integrity.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":52251839,"openaccessinfo":{"externalids":{"MAG":"2341965964","ACL":null,"DOI":"10.15330\/JPNU.2.1.77-84","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background and Objectives Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertrophy inducing medium. We investigated how intrinsic TGF-\u03b2 signaling is altered in pro-hypertrophic conditions. Methods and Results Human bone marrow derived MSC were chondrogenically differentiated in 3D culture. At day 14 medium conditions were changed to 1. pro-hypertrophic by addition of T3 and withdrawal of TGF-\u03b2 and dexamethasone 2. pro-hypertrophic by addition of BMP 4 and withdrawal of TGF-\u03b2 and dexamethasone and 3. kept in prochondrogenic medium conditions. All groups were treated with and without TGF\u03b2-type-1-receptor inhibitor SB431542 from day 14 on. Aggregates were harvested for histo- and immunohistological analysis at d14 and d28, for gene expression analysis (rt-PCR) on d1, d3, d7, d14, d17, d21 and d28 and for Western blot analysis on d21 and d28. Induction of hypertrophy was achieved in the pro-hypertrophic groups while expression of TGF\u03b2-type-1- and 2-receptor and Sox 9 were significantly downregulated compared to pro-chondrogenic conditions. Western blotting showed reduced phosphorylation of Smad 2 and 3 in hypertrophic samples, reduced TGF-\u03b2-1 receptor proteins and reduced SOX 9. Addition of SB431542 did not initiate hypertrophy under pro-chondrogenic conditions, but was capable of enhancing hypertrophy when applied simultaneously with BMP-4. Conclusions Our results suggest that the enhancement of hypertrophy in this model is a result of both activation of pro-hypertrophic BMP signaling and reduction of anti-hypertrophic TGF\u03b2 signaling.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73483386,"openaccessinfo":{"externalids":{"MAG":"2916369853","ACL":null,"DOI":"10.15283\/ijsc18088","PubMedCentral":"6457698","ArXiv":null},"license":null,"url":"http:\/\/www.ijstemcell.com\/journal\/download_pdf.php?doi=10.15283\/ijsc18088","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Endocardial fibroelastosis (EFE) is a rare heart disease characterized by the thickening of the endocardium caused by massive proliferation of collagenous and elastic tissue, usually leading to impaired cardiac function. Thrombosis is a complication of EFE that suggests poor prognosis.Case presentation: The present report describes an EFE patient with multiple cardiovascular thrombi. To the best of our knowledge, this is the first reported case of three-dimensional (3D) and contrast echocardiography use in EFE with multiple ventricular thrombi. The clinical features and outcomes of this rare condition between 1966 and 2019 are also reviewed.Conclusions: Through the combination of 3D and contrast echocardiography, the thrombus can be displayed more accurately and vividly, including its nature and density and the connection between the base of the thrombus and ventricular wall. EFE prognosis with left ventricular thrombus is generally poor.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238089200,"openaccessinfo":{"externalids":{"MAG":"3175821786","ACL":null,"DOI":"10.21203\/rs.3.rs-94766\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-94766\/v1.pdf?c=1603475970000","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Big data is more than a matter of size; it is an emerging paradigm of data of very large size (volume) and fast in\/out (velocity), from various sources (variety), and of high value for knowledge extraction and decision making. Technological advances in data gathering have led to a rapid proliferation of big data in diverse areas such as remote sensing, medicine, the Internet, and social sectors. Such data brings opportunities and challenges to scientists and engineers. In order for us to make use of this massive amount of data, new data management and computational approaches are needed to permit scientists and engineers to analyze the data in (nearly) real time, often in a distributed or streaming manner. Various technologies are being discussed, and some have been realized, to support the handling of big data. In addition, big dataset cannot be stored in one location, and massively parallel processing databases and scalable storage systems are being designed to store the large datasets. What is more, big data generates an industry of supporting architectures; many cloud computing platforms and frameworks are developed to handle the big data operations, such as MapReduce. To deal with different properties of big data, different algorithms also need to be developed. Overall, big data is an opportunity to find insights in new and emerging types of data and content, to make models more agile, and to answer questions that were previously considered beyond our reach. The purpose of this special is to highlight some recent advancement to address such challenges in the big data era.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":22021337,"openaccessinfo":{"externalids":{"MAG":"2241288562","ACL":null,"DOI":"10.1109\/JCN.2015.000101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"At times, it would appear that the only constant feature of influenza is inconstancy. The antigenic structure of the influenza A virus undergoes frequent alterations. In some years, the alterations are relatively small (antigenic drift), while in others, they are drastic (antigenic shift). Antigenic shift or significant antigenic drift decreases the efficacy of a particular influenza vaccine, requiring frequent updating of the vaccine formulation. Published estimates of vaccine efficacy have varied widely since the vaccine's introduction in the early 1940s. In some studies, such as that by Foy et al in this issue ofThe Journal(p 1736), the incidence of respiratory illness did not differ noticeably between vaccinated and unvaccinated groups, while in other studies, the vaccine efficacy (ie, the percent of decrease in illness rates in vaccinees) has been as high as 90%. 1 The practice of expressing vaccine efficacy as a single number belies the fact that","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":28239834,"openaccessinfo":{"externalids":{"MAG":"2068711248","ACL":null,"DOI":"10.1001\/JAMA.1981.03310420052032","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"2014 We have used (e,2e) coincidence techniques to study electron momentum densities as a function of binding energy and momentum in thin films. The experiment employs symmetric coplanar geometry with incident electron beam energy of 10 keV. The outgoing electrons are retarded to about 100 eV before being dispersed in identical hemispherical analysers and counted in one-dimensional position-sensitive detectors consisting of multichannel plates and resistive anodes. Binding energy spectra are obtained by stepping the incident energy through a predetermined range. In amorphous carbon films 80 A thick, we have obtained electron momentum distributions for binding energies from 0 to 40 eV with momentum as parameter (0, 0.4 and 0.8 atomic units). The results clearly show contributions from the 03C0and 03C3bands and demonstrate the usefulness of the method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207837712,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The solvent-composition dependence of quenching triplet states of benzophenone (3BP) by anisole in acetonitrile\u2013water (ACN\u2013H2O) mixtures was investigated by laser flash photolysis over the water mole fraction (xw) increasing from 0 to 0.92. Single exponential decay of 3BP was observed over the whole composition range. The quenching rate constant consistently increased with the water content but increased far more rapidly with xw > 0.7. The water-triggered electron-transfer (ET) mechanism was confirmed by a steeply growing quantum yield of the benzophenone ketyl radical anion, escaping back-ET when the partial water volume exceeded the acetonitrile one. The water-content influence on the 3BP quenching rate was described by a kinetic model accounting for the microheterogeneous structure of the ACN\u2013H2O mixtures and the very different solubility of the reactants in the solvent components. According to the model, the ET mechanism occurs at a rate constant of 1.46 \u00d7 109 M\u20131 s\u20131 and is presumably assisted by the ACN\u2013H2O hydrogen-bonding interaction.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":219587423,"openaccessinfo":{"externalids":{"MAG":"3033645289","ACL":null,"DOI":"10.1021\/acs.jpcb.0c02635","PubMedCentral":"7590979","ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7590979","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"To the Editor: Heemskerk et al. (Jan. 14 issue)1 report no survival benefit for intensified antituberculosis treatment for patients with tuberculous meningitis in Vietnam, a finding that was contrary to the results of our study in Indonesia.2 Our unblinded study was smaller and had a higher proportion of patients with advanced tuberculous meningitis. However, we think that the contrasting results are explained by the dose of rifampin that was administered. The Vietnam study compared 10 mg of rifampin per kilogram of body weight per day with an increased dose of 15 mg of rifampin per kilogram, whereas we evaluated 13 mg of rifampin per kilogram administered intravenously. The high dose used in our study resulted in an increase in rifampin exposure in blood and cerebrospinal fluid by a factor of 3, with a relationship between the drug level and the therapeutic response.3 In our study, 38% of patients who were receiving 13 mg of rifampin per kilogram had drug exposure that was lower than the target exposure, which suggests that the dose was not high enough. Recent trial data for pulmonary tuberculosis also support higher doses of rifampin than that used in the Vietnam study. Regimens consisting of doses of less than 35 mg of rifampin per kilogram did not reduce the time to culture conversion.4 We are currently evaluating similarly increased rifampin doses for the treatment of tuberculous meningitis to prepare for a phase 3 trial. Pharmacokinetic and pharmacodynamic analyses may show how many patients in the Vietnam trial with its modest dose increase reached target exposures of rifampin.3","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":347627,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1056\/NEJMc1602291","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nowadays, small series in the automotive manufacturing industry are becoming more and more important, mainly because of the development of the electric car and also due to the shorter life cycles of products. In such a competitive field, where technologies are continu-ously being improved and new alternatives presented, new and more flexible manufacturing methods are required. \nTypical production methods in this industry present a lack of flexibility because of the use spe-cific fixtures and jigs, which normally can just be used in one or few designs. \nSince high investment costs are not bearable for small series, economic solutions need to be established, in order to satisfy both those manufacturers whose production volumes are small and those who develop new prototypes. \nAs a solution, the Chair of Production Engineering of E-Mobility Components (PEM) started the ProeK project (Produktionseffizienz in der Kleinserie) in which developed a flexible concept which enables shifting the intelligence from the jig into the part, as well as an auto-mated laser welding process. This jigless body shop concept, apart from making the manufac-turing more flexible, further makes it faster and reduces the investment costs. \n \nThe basic idea is that the body parts are: first, cut by laser from metal sheets, and secondly bent to get the desired geometry. New design variations can be easily, fast and economically created modifying the CAD designs. Each piece integrates joints that act as self-positioning elements before welding, which is what makes the absence of proper fixtures possible. \n \nThen comes the final part, the welding process, which is done by laser and solves the challenges \nand limitations that other methods such as spot welding and MIG welding present: distortion, \nhigh maintenance, need of flanges, etc. Moreover, it allows automation, agility and \ngood union quality. To achieve this goals, a diverse set of laser welding parameters have been \ndeveloped in previous works. \n \nWithin the Proek, aim of this Master thesis, as referred in its title, is to increase the body in \nwhite (BIW) geometrical accuracy through fixtureless Body Shop. In other words, to deal with \nthe tolerance issue in this new manufacturing method presented by the PEM.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":116804733,"openaccessinfo":{"externalids":{"MAG":"2769179856","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We here present new results on the classical work of the optimum rotor. The emphasis is put vortex theory for which we have developed a new analytical method to determine the loading on an optimum win turbine rotor. The introduction of the work is a repetition of results using momentum theory. This is included in order to validate and compare the new model at simplified situations, such as a rotor operating without swirl and\/or a rotor with infinite many blades.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110974516,"openaccessinfo":{"externalids":{"MAG":"2103037161","ACL":null,"DOI":"10.1088\/1742-6596\/75\/1\/012009","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/75\/1\/012009\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Levamisole-induced vasculitis (LIV) is becoming an increasingly common entity secondary to both rising cocaine use in the UK and high levels of adulteration of cocaine with various contaminants. We report the first documented case of LIV secondary to adulterated cocaine in Ireland, which presented as a 6-year history of recurrent vasculitis of unknown aetiology. Classically, LIV is diagnosed by a combination of positive ANCA serology and agranulocytosis however, given the frequency of cocaine use, we urge acute physicians to consider the diagnosis in cases of typical retiform (angulated) purpura in association with a history of cocaine use.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39086454,"openaccessinfo":{"externalids":{"MAG":"2979246925","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors describe the association of epibulbar choristomas with linear cutaneous nevi of the epidermal and sebaceous variety in 24 cases reported in the literature. The choristomas are of the bilateral, extensive, multiple and complex type. The associated ocular and systemic findings include lid and uveal coloboma, lid choristoma, alopecia, convulsions and growth retardation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43117200,"openaccessinfo":{"externalids":{"MAG":"2112101362","ACL":null,"DOI":"10.3109\/13816818409007846","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An inverse perturbation method is described for solving the general inverse eigenvalue problem. By taking the analysis of the rotor system as example based upon FEM,the new inverse perturbation method for structural design with specified low-order natural frequencies or frequency constraint bands is detailed as well as its complete theoretical basis. Moreover, formulations to calculate the inverse perturbation parameter e and method to select the corresponding e's value properly are also proposed. The proposed method is characterized in reducing frequency analysis and suitable for large and small structural changes alike. Finally, several different numerical examples for inverse cigenvalue problem are discussed to illustrate the method, which show that this inverse perturbation method is general and can be applied to other type of structure or element.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118782514,"openaccessinfo":{"externalids":{"MAG":"995753865","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary.\u2002 Gaussian process models have been widely used in spatial statistics but face tremendous computational challenges for very large data sets. The model fitting and spatial prediction of such models typically require O(n3) operations for a data set of size n. Various approximations of the covariance functions have been introduced to reduce the computational cost. However, most existing approximations cannot simultaneously capture both the large\u2010 and the small\u2010scale spatial dependence. A new approximation scheme is developed to provide a high quality approximation to the covariance function at both the large and the small spatial scales. The new approximation is the summation of two parts: a reduced rank covariance and a compactly supported covariance obtained by tapering the covariance of the residual of the reduced rank approximation. Whereas the former part mainly captures the large\u2010scale spatial variation, the latter part captures the small\u2010scale, local variation that is unexplained by the former part. By combining the reduced rank representation and sparse matrix techniques, our approach allows for efficient computation for maximum likelihood estimation, spatial prediction and Bayesian inference. We illustrate the new approach with simulated and real data sets.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15168330,"openaccessinfo":{"externalids":{"MAG":"1794957547","ACL":null,"DOI":"10.1111\/j.1467-9868.2011.01007.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/academic.oup.com\/jrsssb\/article-pdf\/74\/1\/111\/49509085\/jrsssb_74_1_111.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper shows how to use R language and environment for statistical computing and graphics to analyze survival data. R was chosen for this purpose because it is a powerful statistical tool, has functions that other commercial statistical software does not have, and it is also free to use. The paper presents how to organize data for survival analysis; how to import it in R; how to describe survival data; how to estimate and plot the distribution of lifetimes; how to test for differences in survival between groups; how to do semi parametric Cox proportional hazard regression; parametric exponential or Weibull regressions; and accelerated failure time regressions; how to diagnose Cox regression to check for proportional hazard assumption, to identify influential observations, and to identify nonlinearity; how to use interaction, stratification and time dependent covariates in Cox regression models in R. The paper also presents the assumptions for the methods described and some important theoretical or more practical issues linked to analysis of survival data such as censoring, or truncation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":58504848,"openaccessinfo":{"externalids":{"MAG":"1693975007","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article demonstrates certain doctrines of the Austrian school of economics are untenable. The focus is on certain aspects of capital theory undergirding Austrian Business Cycle theory. Quotations from the Austrian school economist Ludwig Lachmann and the Italian-Cambridge economist Joan Robinson exhibit common findings on the impact of expectations on the valuation of capital goods and the consequent difficulties in aggregating capital across individuals. This paper demonstrates an entrepreneur may simultaneously classify a capital good into several orders, as orders of goods are defined by Austrian economists. Hayekian triangles are defined. This paper demonstrates that the shape of a Hayekian triangle varies with the interest rate, even if real resources are not reallocated across stages of production. It is demonstrated, by means of an example, that no tendency need exist for entrepreneurs to respond to lower interest rates by reallocating resources from producing low order goods to producing higher order goods, or otherwise increasing the capital-intensity of the structure of production.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":152294753,"openaccessinfo":{"externalids":{"MAG":"1486159835","ACL":null,"DOI":"10.2139\/ssrn.921183","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A hierarchical frequency-domain robust component failure detection (RCFD) scheme is proposed for the diagnosis of large-scale analog circuits with measurement noises based on the design of robust detection filters and robust residual thresholds. The robust residuals generated by the robust detection filters are employed to realize both fault isolation (FI) and component failure detection (CFD). A procedure for the design of robust detection filters is proposed and the associated rule for the selection of measurement variables is suggested. Furthermore, the effect of the measurement noises to the diagnostic result can be reduced by the proper design of residual thresholds, and the robustness of the diagnosis is enhanced. Finally, an example is illustrated to show the efficacy of the proposed method.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110054854,"openaccessinfo":{"externalids":{"MAG":"2163748821","ACL":null,"DOI":"10.1109\/81.557362","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In a 3-year study (2008 to 2011) to estimate the prevalence and the contamination sources of Listeria monocytogenes in pork meat in Sardinia, Italy, 211 samples were collected from five Sardinian swine slaughterhouses: 171 samples from slaughtered pigs and 40 from the slaughterhouse environment. Fifty L. monocytogenes isolates were characterized by PCR-based serotyping, presence of virulence-associated genes, and pulsed-field gel electrophoresis restriction analysis. The overall prevalence of L. monocytogenes was 33% in swine carcasses, 7% in cecal material, 23% on meat contact surfaces, and 25% on noncontact surfaces. Only two serotypes were detected: 1\/2c (78%) and 1\/2a (22%). In all, based on the presence of virulence-associated genes, eight pathogenic profiles were detected. Only 42% of all isolates carried the full complement of virulence-associated genes and were allotted to profile 1. Six pulsed-field gel electrophoresis profiles persisted in the slaughterhouses; restriction profiles appeared to be specific to each plant.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22253445,"openaccessinfo":{"externalids":{"MAG":"2328633884","ACL":null,"DOI":"10.4315\/0362-028X.JFP-12-505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper examines key problems and encouraging trends in the evolution of forensic psychology, in terms of elaboration of expert criteria for the forensic psychological evaluation of legally relevant characteristics of examinees. The need for continued practice-based scientific inquiry in this area of forensic science is emphasized","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":246060000,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.30764\/64\/1819-2785-2016-1-10-15","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.30764\/64\/1819-2785-2016-1-10-15","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Recent research has identified the human T-lymphotropic virus type III (HTLV-III) as a probable etiologic agent of the acquired immune deficiency syndrome (AIDS). This has prompted the U.S. Public Health Service to recommend that all blood used for transfusions or in the manufacture of blood products be screened. An enzyme-linked immunosorbent assay (ELISA) has been approved for use as a screening test. From the perspective of the low-risk blood donor, however, our analysis indicates that the expected utility of no-testing may exceed that of testing. This is primarily due to the risk of a false-positive test result. It follows that informed low-risk individuals may be hesitant to donate blood. We support the discarding of blood that tests positive on ELISA but, to decrease donor risk, a positive confirmatory test, such as the Western blot, should be considered as necessary before the testing outcome is treated as positive from the donor's perspective. Additionally, individuals should be given the option to donate blood without being told the testing outcome.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12636828,"openaccessinfo":{"externalids":{"MAG":"2320175880","ACL":null,"DOI":"10.1089\/AID.1.1986.2.5","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dubbed a safer C, Rust is a modern programming language that combines memory safety and low-level control. This interesting combination has made Rust very popular among developers and there is a growing trend of migrating legacy codebases (very often in C) to Rust. In this paper, we present a C to Rust translation approach centred around static ownership analysis. We design a suite of analyses that infer ownership models of C pointers and automatically translate the pointers into safe Rust equivalents. The resulting tool, Crown, scales to real-world codebases (half a million lines of code in less than 10 seconds) and achieves a high conversion rate.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":257631870,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2303.10515","PubMedCentral":null,"ArXiv":"2303.10515"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mobile malware is increasing more and more in complexity; current signature based antimalware mechanisms are not able to detect attacks, since trivial code transformations may evade detection. Furthermore, antimalware, when correctly label an application as malicious, are able to quarantine or delete the application, but not to allow the user to install and safely use it. Here we present a model checking based approach to locate and inhibit malicious behaviors: we suppose the specification of programs in terms of process algebra language LOTOS, malicious behaviors specified by temporal logic formulae, and define a method to retrieve, from the specifications, the description of the infected part of the program. We refer as example to some Android malware and derive LOTOS specification automatically from the Java Bytecode corresponding to Android's app. The method consists of a set of rules building the LOTOS processes mirroring the behavior of the malware possibly contained in the app; besides the description of the infected part of the code, we give also a way to block the malware attack, putting the basis to disinfect the application. The method can be applied at any level of complexity, so allowing the precise location of malicious behaviors.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1758388,"openaccessinfo":{"externalids":{"MAG":"2621318747","ACL":null,"DOI":"10.5220\/0006287906730652","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 103rd Annual Meeting 2012\u2010\u2010 Mar 31\u2010Apr 4, 2012; Chicago, IL\n\nTo date, more than 200 angiogenesis inhibitors have been reported. These include only a few antiangiogenic peptide drugs. In addition, many molecules upregulated on angiogenic endothelial cells have been explored in the past decades. One of these is integrin \u03b1v\u03b23, which recognizes RGD (Arg-Gly-Asp) motifs in extracellular protein components. Targeting the \u03b1v\u03b23 integrin with drugs may provide an opportunity to destroy tumor vessels without harmful effects on microvessels of normal tissues. Multivalency is a strategy for increasing the binding affinity of compounds ostensibly to increase their potency or imaging potential. Surprisingly, multivalent versions of successful drugs showing enhanced binding have not always demonstrated enhanced therapeutic efficacy. For example, multivalent RGDs have not generally shown better therapeutic efficacy. In our study, we prepared a multivalent nonpeptide integrin \u03b1v\u03b23 antagonist (multivalent IA, 4-[2-(3,4,5,6-tetrahydropyrimidine-2-ylamino)ethyloxy]benzoyl-2-(S)-aminoethylsulfonyl-amino-halanine monomer, dimer and trimer) for anti-tumor therapy. The anti-tumor efficacies of the IA multivalent compounds were evaluated in B16F10 melanoma tumor-bearing mice. Tumors were inoculated subcutaneously and allowed to progress before treating. IA compounds were given by intraperitoneal injection every 12 hours for 14 days. It was observed that 30 mg\/kg of IA-trimer showed higher antitumor efficacy and lower toxicity compared to IA-Monomer and IA-Dimer, as shown by changes in tumor volume against control group (IA-Trimer, 32.05 % > IA-Dimer, 45.33 % > IA-Monomer 59.29 %). Based on these results, we conclude that the success of a multivalent strategy depends on the details of the individual components and how they are put together. This may be the first \u03b1v\u03b23 multivalent ligand showing clear enhancement in anti-tumor effectiveness.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3859. doi:1538-7445.AM2012-3859","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":73069920,"openaccessinfo":{"externalids":{"MAG":"2092762634","ACL":null,"DOI":"10.1158\/1538-7445.AM2012-3859","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Zingiberaceae family is a rich source of diverse bioactive phytochemicals. It comprises about 52 genera and 1300 species of aromatic flowering perennial herbs with characteristic creeping horizontal or tuberous rhizomes. Notable members of this family include ginger (Zingiber officinale Roscoe), turmeric (Curcuma longa L.), Javanese ginger (Curcuma zanthorrhiza Roxb.), and Thai ginger (Alpinia galanga L.). This review focuses on two main classes of bioactive compounds: the gingerols (and their derivatives) and the curcuminoids. These compounds are known for their antioxidant activity against several maladies. We highlight the centrality of their antioxidant activities with notable biological activities, including anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, antimicrobial, and anticancer effects. We also outline various strategies that have been applied to enhance these activities and make suggestions for research areas that require attention.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250160417,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/antiox11071281","PubMedCentral":"9311506","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2076-3921\/11\/7\/1281\/pdf?version=1656413459","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A-C: H (Hydrogenated amorphous carbon) diamond like carbon(DLC) film is the low stabilities of chemical and mechanical properties at high temperatures. Some researchers reported that Raman spectra shown significant conversion of DLC films to nano-crystalline graphite on heating in ambient air at temperatures above 300\u00b0C and conversion to nano-crystalline graphite was completed by 450~600\u00b0C In this study, DLC films(thickness : 1.5-m) were deposited on p-type (100) silicon films by using C6H6 and C6H14 plasma produced with a 13.6MHz RF source. To investigate the mechanical stability of DLC films below 250\u00b0C, we thermally aged the films for different aging temperatures (150\u00b0C, 200\u00b0C, 250\u00b0C) and times (0: virgin, 120, 240, 360 hours). By using indentation test and Raman spectra analyses, it has been found that the H3\/E2 decreases with increasing I(D)\/I(G) ratio. Also we confirmed that sample-2(precursor gas: C6H14) had better mechanical characteristic and thermal stability than the sample-1(precursor gas: C6H6).","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":136781445,"openaccessinfo":{"externalids":{"MAG":"2068814121","ACL":null,"DOI":"10.4028\/www.scientific.net\/KEM.353-358.311","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A stable discharge was produced in atmospheric air using water as a cathode. Spectral lines of elements dissolved in tap water could be observed. It is demonstrated that the appearance of these spectral lines is a consequence of cathode sputtering of water during the discharge. The intensity of the lines was found to depend strongly on the acidity of the water. This kind of discharge gives a possibility for continuous analysis of water and waste water solutions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250775300,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/26\/12\/015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The authors investigated the relationship between attention-deficit\/hyperactivity disorder (ADHD) and cigarette smoking in siblings of ADHD and non-ADHD probands. They conducted a 4-year follow-up of siblings from ADHD and control-group families. In the siblings of ADHD probands, ADHD was associated with higher rates and earlier onset of cigarette smoking. There was also a significant positive association between cigarette smoking and conduct disorder, major depression, and drug abuse in the siblings, even after adjusting for confounding variables. Moreover, smoking was found to be familial among ADHD families but not control-group families. Our findings indicate that ADHD is a risk factor for early initiation of cigarette smoking in the high-risk siblings of ADHD probands.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28391296,"openaccessinfo":{"externalids":{"MAG":"1973135962","ACL":null,"DOI":"10.3109\/10550499709136987","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper uses high-frequency continuous intraday electricity price data from the EPEX market to estimate and forecast realized volatility. Three different jump tests are used to break down the variation into jump and continuous components using quadratic variation theory. Several heterogeneous autoregressive models are then estimated for the logarithmic and standard deviation transformations. Generalized autoregressive conditional heteroskedasticity (GARCH) structures are included in the error terms of the models when evidence of conditional heteroskedasticity is found. Model selection is based on various out-of-sample criteria. Results show that decomposition of realized volatility is important for forecasting and that the decision whether to include GARCH-type innovations might depend on the transformation selected. Finally, results are sensitive to the jump test used in the case of the standard deviation transformation.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":157122086,"openaccessinfo":{"externalids":{"MAG":"2595826589","ACL":null,"DOI":"10.1002\/FOR.2463","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract This study investigated the distribution of incentives (e.g., certificates, badges) for massive open online course (MOOC) completion, and relationships between incentives and MOOC outcomes. Participants were 779 MOOC students internationally who participated in at least 303 different MOOCs offered by at least 12 providers. MOOC participants most commonly intended to receive, and in actuality received, free and paid course certificates of completion; other incentives (e.g., digital badges, postsecondary credits) were far less common. In addition, MOOC participants' intentions to receive both free and paid certificates were consistently and positively related to perceived learning and course completion, net other factors. (Keywords: massive open online courses, MOOCs, motivation, incentives, microcredentials, certificates of completion)","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":168898140,"openaccessinfo":{"externalids":{"MAG":"2748324764","ACL":null,"DOI":"10.1080\/15391523.2017.1358680","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Natto, the richest known source of menaquinone 7 (MK7), is traditionally produced via Solid Substrate Fermentation (SSF) by Bacillus subtilis natto on cooked soy beans. In this work we report a threefold increase in MK7 concentration through the use of a mixture of soy protein granules and nixtamalized corn grits. The effects of fermentation processing factors were investigated and optimized in laboratory scale. These factors include initial moisture content, incubation temperature, incubation time, \u03b1-amylase pretreatment and solid substrate medium. Response surface methodology (RSM) was used to develop a mathematical model to identify the optimum values of key process variables to increase MK7 concentration; the model was also validated experimentally. The polynomial model fitted the experimental data well with R2 = 0.89 and R2 (adj) = 0.83. MK7 production was increased from 57.78 \u00b1 1.57 mg\/kg to 67.01 \u00b1 0.18 mg\/kg when the strain was cultivated at optimum conditions predicted by statistical approach (70% initial moisture, 35\u00b0C, 4 days, 10 \u00b5L\/g amylase and equal substrate mix) as compared to basal conditions (60% initial moisture, 40\u00b0C, 6 days, 10 \u00b5L\/g amylase and equal substrate mix).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100704396,"openaccessinfo":{"externalids":{"MAG":"2314398692","ACL":null,"DOI":"10.2202\/1556-3758.2314","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Purpose\nThe scant literature on MICE (meetings, incentives, conferences and exhibitions) tourists' gambling behavior calls for a need to explore how their decision to gamble (hereafter, \"gambling decision\") may unfold. Consequently, several questions germane to the inter-relationships among event tourists' characteristics, casinos attributes, and gambling behaviors remain largely unaddressed. This paper aims to address the void in the literature by investigating event participants' gambling decision.\n\n\nDesign\/methodology\/approach\nData were collected based on two samples, and a multilevel design was used to test the proposed model. Demographic and event-related participant characteristics were examined as antecedents of gambling decision at the individual level. Event goers' accommodation characteristics such as brand equity and type of hotel were explored as cross-level effects on the individual-level factors and relationships.\n\n\nFindings\nResults of the study illustrate a joint influence \u2013 in terms of both direct and moderating effects \u2013 of individual-level and organizational-level characteristics on gambling decision. In particular, brand equity moderates the relationships leading from demographic and event-related characteristics to gambling decision.\n\n\nPractical implications\nThe inter-relationships among events, accommodations and casinos present an opportunity for hospitality practitioners to better integrate these three services in a more coherent experiential offering for the ever-demanding MICE attendees. Findings also help practitioners to justify their targeting strategy.\n\n\nOriginality\/value\nThe proposed framework presents the dynamic nature of the hospitality industry in which the event, hotel and casino sectors are interdependent, a picture hitherto prevented by the single-level oriented nature of gambling and hospitality research which largely focuses on the individual perspective. Given the dynamic nature of the hospitality industry, the findings elucidate a complex interdependency of customer needs.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":200088694,"openaccessinfo":{"externalids":{"MAG":"2963913519","ACL":null,"DOI":"10.1108\/IJCHM-05-2018-0434","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To realize the remote operation of the slit lamp microscope for department of ophthalmology consultation, and visual display the real-time status of remote slit lamp microscope, a remote slit lamp microscope consultation system based on B\/S structure is designed and implemented. Through framing the slit lamp microscope on the website system, the realtime acquisition and transmission of remote control and image data is realized. The three dimensional model of the slit lamp microscope is established and rendered on the web by using WebGL technology. The practical application results can well show the real-time interactive of the remote consultation system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":80036,"openaccessinfo":{"externalids":{"MAG":"2409756826","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using f-MRI, we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of nine akinetic PD patients and compared to that of healthy volunteers. Compared with normal subjects, PD patients showed a reduction of activation of motor and SMA areas, an increase of activation of parietal areas and a bilateral activation of cerebellar hemispheres, which are likely to participate in the attempt to recruit parallel motor circuits in order to overcome the striatocortical defective loop.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41868724,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bayesian deep learning approaches assume model parameters to be latent random variables and infer posterior distributions to quantify uncertainty, increase safety and trust, and prevent overconfident and unpredictable behavior. However, weight-space priors are model-specific, can be difficult to interpret and are hard to specify. Instead, we apply a Dirichlet prior in predictive space and perform approximate function-space variational inference. To this end, we interpret conventional categorical predictions from stochastic neural network classifiers as samples from an implicit Dirichlet distribution. By adapting the inference, the same function-space prior can be combined with different models without affecting model architecture or size. We illustrate the flexibility and efficacy of such a prior with toy experiments and demonstrate scalability, improved uncertainty quantification and adversarial robustness with large-scale image classification experiments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":259836798,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2307.06055","PubMedCentral":null,"ArXiv":"2307.06055"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The eigenvalue problem for the p-Laplace operator with p>1 on planar domains with the zero Dirichlet boundary condition is considered. The Constrained Descent Method and the Constrained Mountain Pass Algorithm are used in the Sobolev space setting to numerically investigate the dependence of the two smallest eigenvalues on p. Computations are conducted for values of p between 1.1 and 10. Symmetry properties of the second eigenfunction are also examined numerically. While for the disk an odd symmetry about the nodal line dividing the disk in halves is maintained for all the considered values of p, for rectangles and triangles symmetry changes as p varies. Based on the numerical evidence the change of symmetry in this case occurs at a certain value p_0 which depends on the domain.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":116344308,"openaccessinfo":{"externalids":{"MAG":"93754912","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1106.0602"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A field experiment was conducted during kharif, 2016 and 2017 in sandy clay loam soils of experimental field at Banaras Hindu University, Varanasi, Uttar Pradesh to find out the effect of leaf colour chart based nitrogen and weed management practices on growth and yield of direct seeded rice. The experiment was laid out in split plot design with four main plot treatments and five sub plot treatments which were replicated thrice. It was found that superior performance of rice in terms of minimum weed density, dry weight and maximum weed control efficiency, growth, yield attributes and yield was observed with application of nitrogen @ LCC < 5 (N4). Among weed management practices application of Pyrazosulfuron @ 20 g a.i ha-1 (PE) fb bispyribac @ 25 g a.i ha-1 at 15-20 DAS (W4) which was comparable with two hand weedings at 20 and 40 DAS (W1) while weedy check (W0) recorded lowest weed control efficiency, yield and yield attributes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":230306098,"openaccessinfo":{"externalids":{"MAG":"3088807005","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Shockwaves provide a useful and rewarding route to the nonequilibrium properties of simple fluids far from equilibrium. For simplicity, we study a strong shockwave in a dense two-dimensional fluid. Here, our study of nonlinear transport properties makes plain the connection between the observed local hydrodynamic variables (like the various gradients and fluxes) and the chosen recipes for defining (or \"measuring\") those variables. The range over which nonlocal hydrodynamic averages are computed turns out to be much more significant than are the other details of the averaging algorithms. The results show clearly the incompatibility of microscopic time-reversible cause-and-effect dynamics with macroscopic instantaneously-irreversible models like the Navier-Stokes equations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15278208,"openaccessinfo":{"externalids":{"MAG":"3103718546","ACL":null,"DOI":"10.1142\/9789814307543_0002","PubMedCentral":null,"ArXiv":"0909.2882"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/0909.2882","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In this study, grey oyster mushroom (Pleurotus pulmonarius) was cultivated in indoor controlled environment to seeking out the possible Risks of contamination and ways of treatment to avoid the contamination. For this, mushroom was cultivated in providing artificial humidifying and Ventilation system to ensure optimum humidity (80-90%) and fresh air Recirculation in different ways of treatment. The ways of treatment were Included as in position of humidifier, frequency of humidifying, plastic Cork of bags opening part and cleaning of humidifier water container. Maximum percentages of bag contamination (2.5-25.30%), cap Contamination (5.6-30.75%), stalk contamination (4.75-23.25%) and root Contamination (2.6-18.45%) were found in front to front humidifier Position, long humidifying with long interval frequency, without plastic Cork, without cleaning and bi- monthly cleaning of humidifier water Container treatment but no diseases and pest infection was found. Whereas, Very low percentages of contamination (0.1-0.5%) were found in Surrounding humidifying position, short humidifying duration with short Interval frequency, with plastic cork and weekly cleaning of humidifier Water container treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237891767,"openaccessinfo":{"externalids":{"MAG":"3182747515","ACL":null,"DOI":"10.32628\/ijsrst2183156","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32628\/ijsrst2183156","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The extinction ratio (ER) of a Mach\u2014Zehnder-interference (MZI) based silicon optical modulator can be strongly influenced by carrier absorption. Moreover, different doping positions can induce different distributions of injected carriers, leading to different ERs. This effect has been experimentally investigated based on the devices fabricated on silicon-on-insulator (SOI) by using a 0.18 \u03bcm CMOS process. Our experiments indicate that a device with a doping position of about 0.5 \u03bcm away from the edge of the rib waveguide has optimal ER.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108520467,"openaccessinfo":{"externalids":{"MAG":"2028836081","ACL":null,"DOI":"10.1088\/1674-4926\/33\/1\/014009","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background To reduce the magnitude of antimicrobial resistance, there is a need to change the knowledge and behavior of future prescribers regarding use and prescription of antibiotics. This can be ensured through the appropriate training of next generation doctors and medical students. But, before planning or strengthening any teaching or training program for any group, it is required to have a conclusive evidence about knowledge, attitude and practices of that group. With this background this study was conducted to assess the knowledge, attitudes and the practices of medical students in India with respect to antibiotic resistance and usage Methods It was a cross-sectional study which was done online through google forms. A semi-structured questionnaire containing a five point Likert scale was used for the data collection. The questionnaire was sent to medical students across India by sharing link through contacts of Medical Students Association of India. Respondent-driven sampling technique was also adopted for the study. Data was analyzed using SPSS v.25 and Microsoft Excel 2016. Results The overall mean score of awareness for the students was 4.36 + 0.39. As compared to first year students, mean score of awareness was significantly higher among students of all the years. A significantly better awareness was also observed among pre final year students as compared to other years. Variable practices have been observed regarding use of antibiotics among medical students. Conclusion The awareness level of medical students regarding antibiotics and its resistance was quite satisfactory. As far as attitude and practices are concerned, there is a significant need for improvements.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":91623107,"openaccessinfo":{"externalids":{"MAG":"2913452153","ACL":null,"DOI":"10.1101\/546713","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2019\/02\/11\/546713.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper presents kernel plugins, a framework for dynamic kernel specialization inspired by ideas borrowed from virtualization research. Plugins can be created and updated inexpensively on-the-fly and they can execute arbitrary user-supplied functions such that neither safety nor performance are compromised. Three key techniques are used to implement kernel plugins: (1) hardware fault isolation, (2) dynamic code generation, and (3) dynamic linking. Hardware fault isolation protects kernel-level services from plugin misbehavior, dynamic code generation enables rapid online creation of arbitrary plugins, and dynamic linking governs the kernel\/plugin interface. \n \nWe discuss the design and implementation of the kernel plugin facility, as well as its advantages and shortcomings. Its use is demonstrated by a range of micro-and macro-benchmarks and a real-life application featuring plugins that dynamically transcode images served by a high-performance kernel web server. Benefits realized from plugins can be both qualitative (adapting services to clients' needs), and quantitative (improving performance through co-location of application plugin code with kernel services). Plugins are implemented in GNU\/Linux on the Intel x86 platform. Reported performance results include plugin upcalls in 0.45-0.62 \u00b5S, dynamic code generation in 4 mS, and linking\/unlinking in 3.1\/1.6 \u00b5S for an image grayscaling plugin - a dynamically code generated 66-line function written in a subset of C. All results are measured on an 866 MHz Pentium III.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":12553021,"openaccessinfo":{"externalids":{"MAG":"145011710","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the multileveled bio-engineering including amino-acids, proteins, organelle, cells, tissues, and organs, control of hetero-biointerfaces is a key technology. In particular, recent development of nanotechnology has made the nanoscaled control possible. In this article, we selected current topics in the hetero-biointerfaces. In the layer-by-layer stacking technique of cells, artificial tissues similar to a blood vessel has been realized. Phospholipid polymers similar to cell membrane were used to control the biomaterial surfaces. Properties of their interfaces with proteins are analyzed focusing on functions of the interface water layers. Selective adsorption of protein molecules on a solid surface is also demonstrated. In the biointerface engineering, nanoscale control play crucial roles.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":95108008,"openaccessinfo":{"externalids":{"MAG":"1996954213","ACL":null,"DOI":"10.1380\/JSSSJ.30.193","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: Review of the book by Egorchenkov D.A., Danyuk N.S. Hybrid Dragon and Chimera of War. \u041coscow, UNITY-DANA Publ., 2019. 367 p. (in Russian)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":182902285,"openaccessinfo":{"externalids":{"MAG":"2946370076","ACL":null,"DOI":"10.24833\/2071-8160-2019-2-65-196-201","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.24833\/2071-8160-2019-2-65-196-201","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"proofed and located out of doors. In addition, the deaerating heater, evaporator, and miscellaneous tanks are mounted out of doors. The steam-generating units in late designs have been of the pressurized type in the South, using only pressure blowers to supply combustion air and remove the furnace gases. Table 7 indicates the details in connection with each of these stations. We believe that the outdoor boiler is firmly established. We do believe, however, that there is an open question as to whether the outdoor type of turbine saves any appreciable investment. W e also feel that for the outdoor boiler and turbine plants, an enclosed central control room with adequate glazing will give the operators needed weather protection, will improve their vision of operating conditions, and will reduce operating manpower. It is also necessary with outdoor design to weatherproof certain pipe lines, which cannot be drained or wherein water may freeze. We have applied antifreeze protection to our more recent outdoor plants. This has been done with electric strip heaters, either with or without monitoring indicators. Protection also can be done by steam tracing various pipe lines. Costs can be reduced b y grouping various lines around a central source of heat. In all, our firm has under design, or has completed, some 25 station units for outdoor service. We believe that the outdoor plant has its place particularly in the type of climate where the plant, is not subject to extremes of weather.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247037829,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/1.4013787","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1115\/1.4013787","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Choices in persistent data models and data organization have significant performance ramifica- tions for data-intensive scientific computing. In experimental high energy physics, organizing file-based event data for efficient per-attribute retrieval may improve the I\/O performance of some physics analyses but hamper the performance of processing that requires full-event access. In-file data organization tuned for serial access by a single process may be less suitable for opportunis- tic sub-file-based processing on distributed computing resources. Unique I\/O characteristics of high-performance computing platforms pose additional challenges. The ATLAS experiment at the Large Hadron Collider employs a flexible I\/O framework and a suite of tools and techniques for persistent data organization to support an increasingly heterogeneous array of data access and processing models.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":63054079,"openaccessinfo":{"externalids":{"MAG":"2506828098","ACL":null,"DOI":"10.22323\/1.282.0852","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/pos.sissa.it\/282\/852\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"This casebook is a classic in civil procedure. It contains lightly-edited cases with extensive explanatory notes, thereby teaching students how to read cases while learning doctrine. Some notes are historical and comparative, giving students a more nuanced understanding than can be obtained from simply studying current law. The book is accessible without sacrificing interest and complexity, providing a sophisticated understanding of civil procedure and the federal system. The eleventh edition has been thoroughly updated with fifteen new principal cases and notes on recent developments in personal jurisdiction, pleading, e-discovery, and class actions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":114313281,"openaccessinfo":{"externalids":{"MAG":"2481495029","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pancreas divisum is a congenital anomaly present in 5-10% of the population and is usually asymptomatic. Pancreatic intraductal papillary mucinous neoplasms (IPMN) are mucinous cystic tumors that have malignant potential and are classified according to their location as IPMN of the main duct, branch duct or mixed type. Larger lesions and those originating in the main duct have an increased risk of malignancy. The real incidence is unknown as most lesions are asymptomatic.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73428276,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17235\/reed.2019.5959\/2018","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific-oa","url":"https:\/\/doi.org\/10.17235\/reed.2019.5959\/2018","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Focused Clinical Question: What are the key considerations for selecting the best surgical approach in mucogingival plastic surgery? Summary: Treatment of gingival recession has become an important therapeutic issue due to the increasing number of cosmetic requests from patients. The dual goals of mucogingival treatment include complete root coverage, up to the cemento-enamel junction, and blending of tissue color between the treated area and non-treated adjacent tissues. Even though the connective tissue graft is commonly considered the \"gold standard\" for treatment of recession defects, it may not always be the best surgical option for every case. Conclusions: Under non-experimental conditions, all root coverage procedures may be effective in terms of complete root coverage and excellent esthetics. Careful analyses of patient- and defect-related factors, however, are key considerations prior to selecting an appropriate surgical technique.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44480276,"openaccessinfo":{"externalids":{"MAG":"2152452778","ACL":null,"DOI":"10.1902\/CAP.2011.100002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT:A rethinking of Bernard Malamud's Rembrandt's Hat (1973), a collection of ten of Malamud's least obviously \"Jewish\" stories, reminds us not only of the changing literary zeitgeist but also the turmoil of Malamud's life in the late 1960s and early '70s. Although Jews people these stories, Jewishness is not a central issue of the collection. Rather, Jewishness and the nature of contemporary life itself are marginal, questionable, ambiguous; the stories explore the themes of communication and faith, the frustrated artist, and especially the responsibility of being human\u2014what it means to be a mentsch\u2014all issues with which Malamud personally wrestled. Malamud weaves that bundle of themes\u2014communication, faith, frustrated artist, mentschlekeit\u2014into the stories, which complement and comment upon one another, carrying on a thematic dialogue among themselves. Each pair of stories, back-to-back, echoes one another's themes and concerns. Thus the ten stories in the book constitute five pairs of stories held in tension with one another, and these late stories place Malamud as a writer whose work is a transition from the period of emergence to the period of \"getting away\" in Jewish American literature.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":221468909,"openaccessinfo":{"externalids":{"MAG":"3081703971","ACL":null,"DOI":"10.5325\/studamerjewilite.39.2.0217","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of the study was to investigate the effects of taurine on biochemical parameters in male Wistar rats co-exposed to chlorpyrifos and lead. Fifty rats were divided into five groups of ten rats each. The distilled water (DW) group received distilled water and the soya oil (SO) group received soya oil (1 ml\/kg). Other groups were treated sequentially with taurine (50 mg\/kg), chlorpyrifos (4.25 mg\/kg, 1\/20th LD50) and lead (233.25 mg\/kg, 1\/20th LD50), and the last group received taurine (50 mg\/kg), chlorpyrifos (4.25 mg\/kg) and lead (233.25 mg\/kg). The treatments were administered once daily by oral gavage. The rats were sacrificed and blood samples were collected after 16 weeks. The serum samples were analyzed for proteins, enzymes, urea and creatinine concentration. The hepatic and renal malondialdehyde concentration and activities of hepatic and renal antioxidant enzymes were evaluated. The results indicated that chronic co-administration of chlorpyrifos (CPF) and lead acetate (LA) induced biochemical alterations in the rats. It is proposed that taurine antioxidant (TA) decreased the alterations in the biochemical parameters partly through its antioxidant, hepatoprotective and nephroprotective properties. It is concluded that taurine is a useful prophylactic agent against biochemical toxicity in individuals that are constantly co-exposed to chlorpyrifos and lead in the environment. \n \n \u00a0 \n \n Key words: Taurine, chlorpyrifos, lead, oxidative stress, biochemical effects.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56395069,"openaccessinfo":{"externalids":{"MAG":"2314714290","ACL":null,"DOI":"10.5897\/JTEHS2013.0291","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bioluminescence in marine systems is dominated by the use of coelenterazine for light production. The bioluminescent reaction of coelenterazine is an enzyme catalyzed oxidative decarboxylation: coelenterazine reacts with molecular oxygen to form carbon dioxide, coelenteramide, and light. One such class is the Ca2+\u2010regulated photoproteins. These proteins bind coelenterazine and oxygen, and trap 2\u2010hydroperoxycoelenterazine, an intermediate along the reaction pathway. The reaction is halted until Ca2+ binding triggers the completion of the reaction. There are currently no reported experimental, atomistic descriptions of this ternary Michaelis complex. This study utilized computational techniques to develop an atomistic model of the Michaelis complex. Extensive molecular dynamics simulations were carried out to study the interactions between four tautomeric\/protonation states of coelenterazine and wide\u2010type and mutant obelin. Only minor differences in binding modes were observed across all systems. Interestingly, no basic residues were identified in the vicinity of the N7\u2010nitrogen of coelenterazine. This observation was surprising considering that deprotonation at this position is a key mechanistic step in the proposed bioluminescent reaction. This work suggests that coelenterazine binds either as the O10H tautomer, or in the deprotonated form. Implicit ligand sampling simulations were used to identify potential O2 binding and migration pathways within obelin. A key oxygen binding site was identified close to the coelenterazine imidazopyrazinone core. The O2 binding free energy was observed to be dependent on the protonation state of coelenterazine. Taken together, the description of the obelin\u2013coelenterazine\u2010O2 complexes established in this study provides the basis for future computational studies of the bioluminescent mechanism. \u00a9 2019 Wiley Periodicals, Inc.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":92553246,"openaccessinfo":{"externalids":{"MAG":"2902432951","ACL":null,"DOI":"10.1002\/jcc.26125","PubMedCentral":null,"ArXiv":null},"license":"publisher-specific, author manuscript","url":"https:\/\/rss.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jcc.26125","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"We live in a complex World. The rate of change and the volume of communication in life today have no parallel at any period in the history of manking. OCDE (2005) consider that the knowledge society is fundamentally reshaping the global economy and, by extension, global society. Because this society relies so profoundly on the creation, diffusion and exploitation of knowledge, the success of governments depends increasingly on the information infrastructure for gathering and utilising knowledge. This papers has as objective explain the how is the knowledge management (km) in Members States of SADC. We concluded that by fact we are in globalization era all members of SADC, principally most delayed, it must define strategies of economic policy that should have as objective promote of their GDP per capita to all population can absorb knowledge that can increase for example, the number of investigators in R&D, and through ease access and increase of information infrastructure, the people in these countries can be more informed about culture, health, education of others countries as well their own country. All governments of the countries where exist low rates of adult alphabetization, low protection of intellectual property, and low access of internet should define economic policy for these area to absorb FDI of enterprises of information technology sector and other where skilled workers is required.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":155808116,"openaccessinfo":{"externalids":{"MAG":"2301075819","ACL":null,"DOI":"10.2139\/SSRN.902423","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Soft-output detection of a multiple-input-multiple-output (MIMO) signal pose a significant challenge in future wireless systems. In this paper, we introduce a soft-output modified metric first (MMF)-LSD algorithm for MIMO detection. We design a scalable architecture and address a method to decrease memory requirements. We provide implementation results for a spatial multiplexing (SM) system with four transmitted streams and with 16- and 64-quadrature amplitude modulation (QAM) on a 0.18-\u03bc m CMOS application specific integrated circuit (ASIC) technology. The MFF-LSD implementation is more efficient than the depth first (DF)-LSD in the crucial low signal-to-noise rate (SNR) region and the detection rate of the 64-QAM implementation is 39.2 Mbps@26 db with 48.2 kGEs complexity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":17152180,"openaccessinfo":{"externalids":{"MAG":"2103526044","ACL":null,"DOI":"10.1109\/TVLSI.2010.2041800","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Exact approaches to combinational equivalence checking, such as automatic test pattern generation-based, binary decision diagrams (BDD)-based, satisfiability-based, and hybrid approaches, have been proposed over the last two decades. Recently, we proposed another exact approach using signal probability. This probability-based approach assigns probability values to the primary inputs and compares the corresponding output probability of two networks via a probability calculation process to assert if they are equivalent. The shortcoming of all these exact approaches is that if two networks are too complex to be handled, their equivalence cannot be determined, even with tolerance. An approximate approach, named the probabilistic approach, is a suitable way to give such an answer for those large circuits. However, despite generally being more efficient than exact approaches, the probabilistic approach faces a major concern of a non zero aliasing rate, which is the possibility that two different networks have the same output probability\/signatures. Thus, minimizing aliasing rate is substantial in this area. In this paper, we propose a novel probabilistic approach based on the exact probability-based approach. Our approach exploits proposed probabilistic equivalence checking architecture to efficiently calculate the signature of network with virtually zero aliasing rate. We conduct experiments on a set of benchmark circuits, including large and complex circuits, with our probabilistic approach. Experimental results show that the aliasing rate is virtually-zero, e.g., 10-6013. Also, to demonstrate the effectiveness of our approach on error detection, we randomly inject errors into networks for comparison. As a result, our approach more efficiently detects the error than a commercial tool, Cadence LEC, does. Although our approach is not exact, it is practically useful. Thus, it can effectively complement exact methods to improve the efficiency and effectiveness of combination equivalence checking algorithms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":24663462,"openaccessinfo":{"externalids":{"MAG":"2165915174","ACL":null,"DOI":"10.1109\/TVLSI.2008.917397","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A dynamical calculation scheme that employs Cartesian coordinates with a z axis normal to the crystal surface to define polarization unit vectors and wavefields is applied to interpret the intensity distribution of crystal truncation rods for surfaces and interfaces. A comparison between this calculation scheme and the asymptotic iteration approach using the conventional presentation of the polarization components of the wavefields, with the sigma and pi components perpendicular to the wavevectors, is presented. It is found that the use of Cartesian coordinate systems can provide correct boundary conditions in determining the wavefield amplitudes, thus leading to a rigorous and general calculation scheme for dynamical diffraction from surfaces and interfaces.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10623344,"openaccessinfo":{"externalids":{"MAG":"1998007712","ACL":null,"DOI":"10.1107\/S010876739801695X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Residual of heavy metals originated from abandoned metal mines in agricultural field can cause adverse effect on ecosystem and eventually on human health. For this reason, remediation of heavy metal contaminated agriculture field is a critical issue. In this study, five different amendments, agriculture lime, dolomite, steel slag, zeolite, and compost, were evaluated for stabilization efficiency of heavy metals in agricultural field. Applied mixing ratio of amendments was varied (2% or 6%) depending on properties of amendments. Result showed that soil pH was increased compared to control (6.1-6.7) after mixing with amendments and ordered as dolomite (7.2~8.3) > steel slag (6.7~8.1) > agriculture lime (6.6~7.4) > zeolite (6.2~6.9) > compost (6.1~7.1). Among other amendments, agriculture lime, steel slag, and dolomite showed the highest stabilization efficiency of heavy metals in soil. For Cd, stabilization efficiency was 49~72%, 51~83%, and 0~36% for agriculture lime, steel slag, and dolomite respectively. In case of Pb, 43~64, 37~73%, and 51~73% of stabilization efficiency was observed for agriculture lime, steel slag, and dolomite respectively. However, minimal effect of heavy metal stabilization was observed for zeolite and compost. Based on result of this study, amendments that can increase the soil pH were the most efficient to stabilize heavy metal residuals and can be adapted for remediation purpose in agricultural field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137132847,"openaccessinfo":{"externalids":{"MAG":"1990533338","ACL":null,"DOI":"10.7745\/KJSSF.2011.44.6.1052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A nonlinear decentralised excitation and governor co-ordinated controller design for hydraulic power plants is proposed to enhance power system transient stability. First, the excitation system and hydro-governor system, considering non-elastic water hammer effect, is modelled as a whole. Then, based on differential geometric theory, the original nonlinear system for multi-machines is exactly linearised by appropriate co-ordinate transformation. After that, linear optimisation control is applied such that the final optimised nonlinear excitation and governor co-ordinated control law can be obtained. To demonstrate the efficiency and analyse the co-ordination mechanism of the proposed controller, simulations on an OMIB system and the EPRI-36 system are performed. Comparison with classical excitation and governor control, nonlinear optimal excitation control, nonlinear robust governor control, the suggested decentralised and co-ordinated control can achieve considerably better performance in improving the transient stability of power systems.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110093221,"openaccessinfo":{"externalids":{"MAG":"2055750042","ACL":null,"DOI":"10.1049\/IP-GTD:20045048","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper develops a two-sided search-matching model with imperfectly observed types and learning. Since agents do not observe one another's type accurately, they first engage in a probationary partnership to learn one another's true type. Using the metaphor ofpremarital cohabitation and marriage, we demonstrate that long-term cohabiting individuals eventually learn each other's true type. We also demonstrate that singles ofeither sex are partitioned into classes and are matched in the same class in equilibrium. We show that sequential learning reduces signalling errors so that the Bayes estimator of the true type converges almost surely to true type. As noisy information is filtered over time, the mismatch risk disappears and the aggregate matching pattern based on true types is restored.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":117721336,"openaccessinfo":{"externalids":{"MAG":"1587509706","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to investigate the relationship between emotion regulation with discipline. The hypothesis in this study is on the way down there is a relationship between emotion regulation to discipline the students of Madrasah Aliyah boarding school Qodratullah ledge.The population in this study is numbered 563 students which is the total number of students of Madrasah Aliyah boarding school Qodratullah ledge. Sample taken based table Isaac and Michael with a standard error of 10% of the population so samples used are 187 students. Measuring instruments used in this research that use two scales, the first scale that emotion regulation is made with reference to the aspects of emotion regulation raised by Gross and scale of discipline made with reference to the aspects of the discipline proposed by Prijidarminto. Methods of data analysis used to test the hypothesis of the research is Correlation Product Moments. All calculations are done using the computer program SPSS (Statistical Program for Social Science) version 20.00.Based on the analysis of research known 0,000 p where p <0.01 then Ha Ho accepted and rejected. It can be said that there is a positive relationship between emotion regulation to discipline students of Madrasah Aliyah boarding school Qodratullah ledge. This can be seen in the analysis of the results of data analysis showed a correlation coefficient (r) indicates the value of 0.329 with significance (p) of 0.000 or p <0.01.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149014830,"openaccessinfo":{"externalids":{"MAG":"2612878242","ACL":null,"DOI":"10.19109\/psikis.v2i1.1054","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper aims at characterising the flow of tourism in the Italian district of Val Pusteria, examining data ranging from 1990 to 2006. Overnight stays, arrivals and average stays in this area are analysed in order to identify cyclical, seasonal and stochastic components and trends. Two seasonal gaps are recognised by separating summer and winter regimes, while there is no evidence supporting the existence of a structural break. With the use of a SARIMA model, the process generated by flow is identified and the impact and persistence of the demand-side shocks are evaluated. Structural characteristics of time series result in the conclusion that the winter tourism regime is in a growing life-cycle model stage, whereas summer tourism is positioned in a mature stage.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128743402,"openaccessinfo":{"externalids":{"MAG":"1850470617","ACL":null,"DOI":"10.2382\/23747","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Published in association with Granada TV, and timed to coincide with a new TV series of six programmes, this book provides information for all Holmes enthusiasts. Plot, cast, production and transmission details for every Sherlock Holmes series and full-length drama produced by Granada over the last ten years is included as well as revealing insights on the making of the programmes. A survey of earlier TV interpretations of the great detective, interviews with the stars and the series creators as well as a location fact-file are included.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":193876265,"openaccessinfo":{"externalids":{"MAG":"1501777794","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Various species and lineages that until recently were identified as Microsternarchus bilineatus (Hypopomidae, Gymnotiformes) have a widespread distribution in the Amazon and Orinoco River basins and across the Guiana shield. Recent molecular studies show five distinct lineages for Microsternarchus from different localities. These results suggest that this previously monotypic genus actually consists of more than one species. Here, we describe the karyotype of M. aff. bilineatus from the Cururutuia River (Bragan\u00e7a, Par\u00e1, Brazil). The diploid number of 48 chromosomes (14 meta-submetacentric\/34 subtelo-acrocentric) is found for males and females, with an XX\/XY sex chromosome system. The nucleolar organizer region is found in the short arm of pair 9. Constitutive heterochromatin occurs in the pericentromeric region of all chromosomes, in the distal region of 3p, 5p, 7p, 8q, 9q, 16q, and Xq, in the interstitial region in 2p, 10q, 11q, and 12q and all along 4p, and in a large block of the Y chromosome. These results indicate extensive karyotype divergence between this population and samples from Igarap\u00e9 Tarum\u00e3 Grande (Negro River, Amazonas, Brazil) studied by other researchers. Moreover, despite the diversity of sex chromosome systems found in Gymnotiformes, the XX\/XY sex chromosome system of M. aff. bilineatus is the first case of Y chromosome degeneration in this order. The present data are valuable to help understand karyotype evolution in Hypopomidae.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19771839,"openaccessinfo":{"externalids":{"MAG":"2592070502","ACL":null,"DOI":"10.1089\/zeb.2016.1383","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The intensely emotional rhetoric and overreactions of Russians and Georgians in their recent war has puzzled outside observers. It is not that the belligerents lack rationality. Humans see the world through cultural lenses that have a particular cut; we all carry pre-rational patterns of action that come to us \"naturally,\" and with origins that are long forgotten or taken for granted. What sociologists call \"habitus,\" the English proverb \"Once a priest, always a priest\" captures nicely (if a bit too categorically \u2013 fortunately, cultural patterns typically contain contradictions and can change over time). By highlighting the key sources of Georgian habitus, we can try to better understand Georgia's hate\/love relationship with Russia and see how the wheel might yet turn.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":54181005,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During the operation of the Fast Flux Test Facility (FFTF), radioactive gases, primarily xenon and krypton, will be produced which will require processing and storing. Two systems have been installed in the FFTF for handling these gases: (1) one to handle, primarily, the reactor cover gas system, and (2) a second to handle the cells and cover gas systems, other than the reactor, whose atmosphere may become contaminated. The system that processes the reactor cover gas, which is argon, is called the Radioactive Argon Processing System (RAPS). The effluent argon from RAPS will normally be sufficiently decontaminated to allow its reuse as the reactor cover gas. If the radioactive level in the RAPS becomes too high, the exhaust stream will be diverted to the Cell Atmosphere Processing System (CAPS), a system which can function as a backup to RAPS. The design and operation of the RAPS and CAPS systems are described and certain safety aspects of the systems are discussed. It is shown that these systems adequately provide the cleanup services required and that they provide the safety margins necessary to assure adequate safety to the public.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":107064928,"openaccessinfo":{"externalids":{"MAG":"1495046733","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Neutrophil migration is responsible for tissue damage observed in inflammatory diseases. Neutrophils are also implicated in inflammatory nociception, but mechanisms of their participation have not been elucidated. In the present study, we addressed these mechanisms in the carrageenan-induced mechanical hypernociception, which was determined using a modification of the Randall-Sellito test in rats. Neutrophil accumulation into the plantar tissue was determined by the contents of myeloperoxidase activity, whereas cytokines and PGE 2 levels were measured by ELISA and radioimmunoassay, respectively. The pretreat-ment of rats with fucoidin (a leukocyte adhesion inhibitor) inhibited carrageenan-induced hyperno-ciception in a dose-and time-dependent manner. Inhibition of hypernociception by fucoidin was associated with prevention of neutrophil recruitment , as it did not inhibit the hypernociception induced by the direct-acting hypernociceptive mediators , PGE 2 and dopamine, which cause hyper-nociception, independent of neutrophils. production in the rat paw was inhibited by the pretreatment with fucoidin. In conclusion, during the inflammatory process, the migrating neutro-phils participate in the cascade of events leading to mechanical hypernociception, at least by mediating the release of direct-acting hypernociceptive mediators, such as PGE 2. Therefore, the blockade of neutrophil migration could be a target to development of new analgesic drugs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264382405,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aside from the degeneration of dopaminergic neurons, inflammation is a key component in the movement disorder Parkinson's disease (PD). Microglia activation as well as elevated cytokine levels were observed in the brains of PD patients, but the specific role of microglia in the disease process is unknown. Here, we generate human cellular models by differentiating iPSCs into dopaminergic neurons and microglia. We combine these cells in co-culture to perform cytokine profiling, representing the final functional outcome of various signaling pathways. For this, we used unstimulated conditions and treatment with inflammatory stressors. Importantly, only co-cultures but not the monocultures responded to IL-1\u03b2 treatment suggesting co-culture-related crosstalk. Moreover, we identified the main types of released cytokines and chemokines in this model system and found a preference for the activation of the chemotaxis pathway in response to all treatments, which informs future studies on the cell-type-specific reaction to inflammatory stimulation. Finally, we detected protein level changes in PD risk factor GPNMB upon stress in microglia, further confirming the link between PD-associated genes and inflammation in human-derived cellular models.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264582566,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/cells12212535","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A GIS polygon shapefile outlining the boundaries of the native input datasets used to construct a seamless, 2-meter resolution digital elevation model (DEM) was constructed for the open-coast region of the San Francisco Bay Area (outside of the Golden Gate Bridge), extending from Half Moon Bay to Bodega Head along the North-central California coastline. The goal was to integrate the most recent high-resolution bathymetric and topographic datasets available (for example, Light Detection and Ranging (lidar) topography, multibeam and single-beam sonar bathymetry) into a seamless surface model extending offshore at least 3 nautical miles and inland beyond the +20 m elevation contour.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":131099427,"openaccessinfo":{"externalids":{"MAG":"2271254090","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A number of studies on human epithelial cells of varying origin have demonstrated integration of recombinant adeno-associated virus (AAV) vectors into a variety of chromosomes compared with the site-specific integration on chromosome 19 predominantly observed for wild-type (wt) AAV. We have constructed a recombinant AAV (rAAV) vector and tested the integration into hematopoietic cells, using the human acute myeloid leukemia cell line AML5 and the human non-Hodgkin's lymphoma cell line OCI-LY18 as targets. The integration sites were visualized by fluorescence in situ hybridization (FISH). Positive signals were observed for chromosomes 1, 2, 3, 8, 14, 15, 19, and Y. The majority of cells demonstrated integration into one specific site. A minority showed simultaneous integration into more than one chromosome. The frequency of observed integrations was not uniformly distributed among chromosomes; for instance, in AML5 chromosome 2 seemed to be favored. Colony-derived AML5 clones bore unique integration patterns indicating successful transduction of clonogenic progenitor cells with high proliferative potential. The integration was stable and observed for more than 12 months after transduction. FISH has been shown to be a powerful tool for detailed analyses of rAAV integration patterns and can be used to evaluate targets and transduction conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22107856,"openaccessinfo":{"externalids":{"MAG":"2032022817","ACL":null,"DOI":"10.1089\/10430349950018616","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The central adenine residue (A) of codon 61 in the human N-ras proto-oncogene, 5'-CGGACAAGAAG-3', has been modified with each enantiomer of the series 1 (DE-1, syn) and series 2 (DE-2, anti) benzo[a]pyrene diol epoxide through total chemical synthesis. The resulting DNA adducts correspond to a trans ring-opening of the oxiranes at the C-10 position of the hydrocarbon by the exocyclic amino group of the purine (the relative stereochemistry between the C-9 and C-10 substituents is trans). The synthesis involved coupling of 6-fluoro-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine with the racemic aminotribenzoates derived from each diol epoxide. The resulting pairs of diastereomeric adducts were converted to the 5'-O-DMT 3'-O-phosphoramidites and incorporated into the DNA sequence through a partially automated procedure. Resolution of the diastereomeric oligomers resulting from each diol epoxide enantiomer was conveniently achieved at the very end of the synthesis. This adds simplicity and efficiency to the preparation of alkylated oligomers through this route. Thermal denaturation of the modified duplexes with a complementary strand, as well as a partially complementary target containing a central apurinic site, has been evaluated. These studies indicate striking differences in the absorbance-temperature co-operativity when the 345 nm pyrene absorption is monitored. The results of such previously undescribed experiments provide a comparison of the physical properties of oligomers that differ in the arrangement of substituents in the hydrocarbon moiety, but are otherwise identical. We believe that such comparisons between diol epoxide-DNA adducts of the same hydrocarbon and those of different hydrocarbons will provide information about the orientation of the hydrocarbon moieties relative to the adjacent bases. Therefore, these results will be useful parameters in the evaluation of structure-activity relationships of diol epoxide-DNA lesions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31981844,"openaccessinfo":{"externalids":{"MAG":"1998268094","ACL":null,"DOI":"10.1093\/CARCIN\/17.12.2747","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study was aimed at improving existing methods of processing of, commonly consumed insects in Lango sub region of Northern Uganda to enhance consumption and improve the nutrition of the people. Insects (crickets, soldier and winged termites) flour processed by either pan frying or boiling followed by sun drying was substituted into honey. The resulting spreads were evaluated by fifty panelists to screen for acceptability by insect species and their processing methods in stage one. Subsequently, the insect and processing method combination most preferred by panelist for spread enrichment was used to determine; the effect of insect flour inclusion level (8, 16 and 24%) and processing temperature (80, 90 and 100\u00b0C) on acceptability and nutritional quality. Data was analyzed using analysis of variance (ANOVA), means were separated using least significant difference test at 5% and results reported as mean \u00b1 Standard Deviation (SD). Honey spread enriched with soldier termite flour processed by pan frying was most preferred. Increased substitution level decreased acceptability; nutrient content increased significantly (p<0.05) with increased insect proportion while processing temperature had a significant (P<0.05) effect on the nutritional quality. Protein digestibility decreased with increase in processing temperature from 59.19 to 45.28%, Fe and Zn solubility increased from 14.09 to 42.89%; 3.06 to 27.17% at 80 and 100\u00b0C, respectively. Spreads enriched with 8% soldier termite flour processed by pan frying at 100\u00b0C had good nutritional and sensory qualities. The study signifies the potential of termite flour in fortifying food products with acceptable sensory and nutritional qualities. \n \n \u00a0 \n \n Key words: \u00a0Edible insects, honey spread, sensory acceptability, nutritional quality.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":164701158,"openaccessinfo":{"externalids":{"MAG":"2606094436","ACL":null,"DOI":"10.5897\/AJFS2016.1463","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Quality management systems especially ISO 9000 has gained great importance in today business with the purpose of offering higher value to the stakeholders. This retrospective study analyzed productivity records of the Barez Industrial Group consisted of eleven companies in Iran, from 1994 to 2001 by the means of Statistical Package for Social Scientists (SPSS 15). One-Sample Kolmogorov-Smirnov Test was used for data normality. The non-parametric 2-related samples Wilcoxon Test was performed. The results show that the implication of ISO 9000 series did not have any significant impact on productivity. The findings of this study show that if quality management systems are considered as a tool for achieving excellence and not as a goal, they can give maximum efficiency and effectiveness; otherwise they would give low or even negative efficiency and effectiveness. This study is based on real achievements not respondents' perceptions. This study will be useful for all sectors of business.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":26944430,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There are few branches of the Theory of Evolution which appear to the mathematical statistician so much in need of exact treatment as those of Regression, Heredity, and Panmixia. Round the notion of panmixia much obscurity has accumulated, owing to the want of precise definition and quantitative measurement. The problems of regression and heredity have been dealt with by Mr. Francis Galton in his epochmaking work on 'Natural Inheritance,' but, although he has shown exact methods of dealing, both experimentally and mathematically, with the problems of inheritance, it does not appear that mathematicians have hitherto developed his treatment, or that biologists and medical men have yet fully appreciated that he has really shown how many of the problems which perplex them may receive at any rate a partial answer. A considerable portion of the present memoir will be devoted to the expansion and fuller development of Mr. Galton's ideas, particularly their application to the problem of bi-parental inheritance . At the same time I shall endeavour to point out how the results apply to some current biological and medical problems. In the first place, we must definitely free our minds, in the present state of our knowledge of the mechanism of inheritance and reproduction, of any hope of reaching a mathematical relation expressing the degree of correlation between individual parent and individual offspring. The causes in any individual case of inheritance are far too complex to admit of exact treatment; and up to the present the classification of the circumstances under which greater or less degrees of correlation between special groups of parents and offspring may be expected has made but little progress. This is largely owing to a certain prevalence of almost metaphysical speculation as to the causes of heredity, which has usurped the place of that careful collection and elaborate experiment by which alone sufficient data might have been accumulated, with a view to ultimately narrowing and specialising the circumstances under which correlation was measured. We must proceed from inheritance in the mass to inheritance in narrower and narrwoer classes, rather than attempt to build up general rules on the observation of individual instances. Shortly, we must proceed by the method of statistics, rather than by the consideration of typical cases. It may seem discouraging to the medical practitioner, with the problem before him of inheritance in a particular family, to be told that nothing but averages, means, and probabilities with regard to large classes can as yet be scientifically dealt with ; but the very nature of the distribution of variation, whether healthy or morhid, seems to indicate that we are dealing with that sphere of indefinitely numerous small causes, which in so many other instances has shown itself only amenable to the calculus of chance, and not to any analysis of the individual instance. On the other hand, the mathematical theory wall be of assistance to the medical man by answering, inter alia, in its discussion of regression the problem as to the average effect upon the offspring of given degrees of morbid variation in the parents. It may enable the physician, in many cases, to state a belief based on a high degree of probability, if it offers no ground for dogma in individual cases. One of the most noteworthy results of Mr. Francis Galton's researches is his discovery of the mode in which a population actually reproduces itself by regression and fraternal variation. It is with some expansion and fuller mathematical treatment of these ideas that this memoir commences.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119875807,"openaccessinfo":{"externalids":{"MAG":"2005825070","ACL":null,"DOI":"10.1098\/RSTA.1896.0007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We study the laser excitation of atomic collision pairs in a differential scattering experiment. The interference structure in the differential cross-section is resolved and shows a considerable variation with the linear polarization of the laser light. A systematic analysis allows the accurate determination of the Condon vectors characterizing the optical transition. The method is thus capable to directly visualize geometric aspects of the collision event, very much like an everyday photography.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120511984,"openaccessinfo":{"externalids":{"MAG":"2002827464","ACL":null,"DOI":"10.1209\/EPL\/I2002-00624-X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nThe objective of this work was to evaluate the utility and the effectiveness of the intraparenchymatous balloon tamponade for transfixing lesions of the liver. An analysis is made of the results of an experimental surgical technique during 12 months in patients with gunshot wounds producing hepatic transfixing lesions.\n\n\nMETHODS\nTwelve patients have been treated, all of masculine sex, with middle age of 22 years, in which the hepatic transfixing lesions have been treated with intraparenchymatous balloon tamponade built intraoperatively with Nelaton and a drain of great latex. This system is filled with physiological solution and hydrosoluble contrast medium for further radiological controls. All the patients have been enrolled at the department of General Surgery of the Hospital \"Jos\u00e9 Maria Vargas\" of Caracas (Central University of Venezuela).\n\n\nRESULTS\nThis method has been used with good results, without postoperative bleeding and neither after the balloon removal.\n\n\nCONCLUSIONS\nThe intraparenchymatous balloon tamponade in the hepatic transfixing lesions is a sure procedure, rapid and easy, particularly in the emergency rooms of countries that have a high index of abdominal trauma with gunshot wounds and they are not always endowed with all the surgical medical requirements to treat these severe and difficult hepatic lesions.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":21539242,"openaccessinfo":{"externalids":{"MAG":"2409743957","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Schizophrenia (SCH) and autism spectrum disorder (ASD) share several common aetiological and symptomatic features suggesting they may be included in a common spectrum. For example, recent results suggest that excitatory\/inhibitory imbalance is relevant in the etiology of SCH and ASD. Numerous studies have investigated this imbalance in regions like the ventromedial and dorsolateral prefrontal cortex (DLPFC). However, relatively little is known about neuroanatomical changes that could reduce inhibition in subcortical structures, such as the caudate nucleus (CN), in neuropsychiatric disorders. We recently showed a significant decrease in calretinin-immunopositive (CR-ip) interneuronal density in the CN of patients with ASD without significant change in the density of neuropeptide Y-immunopositive (NPY-ip) neurons. These subtypes together constitute more than 50% of caudate interneurons and are likely necessary for maintaining excitatory\/inhibitory balance. Consequently, and since SCH and ASD share characteristic features, here we tested the hypothesis, that the density of CR-ip neurons in the CN is decreased in patients with SCH. We used immunohistochemistry and qPCR for CR and NPY in six patients with schizophrenia and six control subjects. As expected, small, medium and large CR-ip interneurons were detected in the CN. We found a 38% decrease in the density of all CR-ip interneurons (P < 0.01) that was driven by the loss of the small CR-ip interneurons (P < 0.01) in patients with SCH. The densities of the large CR-ip and of the NPY-ip interneurons were not significantly altered. The lower density detected could have been due to inflammation-induced degeneration. However, the state of microglial activation assessed by quantification of ionized calcium-binding adapter molecule 1 (Iba1)- and transmembrane protein 119 (TMEM119)-immunopositive cells showed no significant difference between patients with SCH and controls. Our results warrant further studies focussing on the role of CR-ip neurons and on the striatum being a possible hub for information selection and regulation of associative cortical fields whose function have been altered in SCH.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":226307676,"openaccessinfo":{"externalids":{"MAG":"3106309857","ACL":null,"DOI":"10.3389\/fnana.2020.581685","PubMedCentral":"7691639","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnana.2020.581685\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We present a differentiable physics engine that can be integrated as a module in deep neural networks for end-to-end learning. As a result, structured physics knowledge can be embedded into larger systems, allowing them, for example, to match observations by performing precise simulations, while achieves high sample efficiency. Specifically, in this paper we demonstrate how to perform backpropagation analytically through a physical simulator defined via a linear complementarity problem. Unlike traditional finite difference methods, such gradients can be computed analytically, which allows for greater flexibility of the engine. Through experiments in diverse domains, we highlight the system's ability to learn physical parameters from data, efficiently match and simulate observed visual behavior, and readily enable control via gradient-based planning methods. Code for the engine and experiments is included with the paper.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-30":1,"unknown":2}},"corpusid":54091129,"openaccessinfo":{"externalids":{"MAG":"2891122218","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The mechanism of electrochemical oxidation of hypophosphite on a polycrystalline platinum electrode was studied by SNIFTIRS (i.e. Subtractively Normalized Interfacial FTIR Spectroscopy) as well as by cyclic voltammetry. The in-situ IR reflectance spectra were analyzed as a function of the Pt electrode potentials in 0.5 mol\/L H 2SO 4 +0.1 mol\/L NaH 2PO 2 solution. The in-situ IR band characteristics are those near 2 100, 1 250 and 1 110 cm -1, assigned as the presence of adsorbed hydrogen atom on Pt and non-adsorbed H 3PO 4 molecule or phosphate species, respectively. It was concluded that both hydrogen atoms and H 2PO 2 are the adsorbed species on Pt in the potential range where the oxidation occurs, and the final oxidation product was H 3PO 4 rather than phosphate, different from the oxidation of hypophosphite on Ni electrode. Accordingly, a new mechanism was proposed for the hypophosphite oxidation on Pt electrodes in acidic media, i.e. in the potential range lower than 0.8 V(vs. SCE) the adsorbed H 2PO 2 was directly oxidized to phosphate via phosphite, and in the potential range higher than 0.8 V the oxygen-adsorbed species on Pt participates in the oxidation of H 2PO 2 into phosphate.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":102026163,"openaccessinfo":{"externalids":{"MAG":"2378056242","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present an Ansatz for the planar five-loop four-point amplitude in maximally supersymmetric Yang-Mills theory in terms of loop integrals. This Ansatz exploits the recently observed correspondence between integrals with simple conformal properties and those found in the four-point amplitudes of the theory through four loops. We explain how to identify all such integrals systematically. We make use of generalized unitarity in both four and D dimensions to determine the coefficients of each of these integrals in the amplitude. Maximal cuts, in which we cut all propagators of a given integral, are an especially effective means for determining these coefficients. The set of integrals and coefficients determined here will be useful for computing the five-loop cusp anomalous dimension of the theory which is of interest for nontrivial checks of the AdS\/CFT duality conjecture. It will also be useful for checking a conjecture that the amplitudes have an iterative structure allowing for their all-loop resummation, whose link to a recent string-side computation by Alday and Maldacena opens a new venue for quantitative AdS\/CFT comparisons.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":119673674,"openaccessinfo":{"externalids":{"MAG":"2171199766","ACL":null,"DOI":"10.1103\/PhysRevD.76.125020","PubMedCentral":null,"ArXiv":"0705.1864"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective To assess the value of in utero placental assessment in predicting adverse pregnancy outcome after reported reduced fetal movements (RFM). Method A non-interventional prospective cohort study of women (N = 300) with subjective RFM at \u226528 weeks' gestation in singleton non-anomalous pregnancies at a UK tertiary maternity hospital. Clinical, sonographic (fetal weight, placental size and maternal, fetal and placental arterial Doppler) and biochemical (maternal serum hCG, hPL, progesterone, PlGF and sFlt-1) assessment was conducted. Multiple logistic regression identified combinations of measurements (models) most predictive of adverse pregnancy outcome (perinatal mortality, birth weight <10th centile, five minute Apgar score <7, umbilical arterial pH <7.1 or base excess <-10, neonatal intensive care admission). Models were compared by test performance characteristics (ROC curve, sensitivity, specificity, positive\/negative predictive value, positive\/negative likelihood ratios) against baseline care (estimated fetal weight centile, amniotic fluid index and gestation at presentation). Results 61 (20.6%) pregnancies ended in adverse outcome. Models incorporating PlGF\/sFlt-1 ratio and umbilical artery free loop Doppler impedance demonstrated modest improvement in ROC area for adverse outcome (baseline care 0.69 vs. proposed models 0.73\u20130.76, p<0.05). However, there was little improvement in other test characteristics (baseline vs. best proposed model: sensitivity 21.7% [95% confidence interval 13.1\u201333.6] vs. 35.8%% [24.4\u201349.3], specificity 96.6% [93.4\u201398.3] vs. 94.7% [90.7\u201397.0], PPV 61.9% [40.9\u201379.3] vs. 63.3% [45.5\u201378.1], NPV 82.8% [77.9\u201386.8] vs. 85.2% [80.0\u201389.2], positive LR 6.3 [2.8\u201314.6] vs. 6.7 [3.4\u20133.3], negative LR 0.81 [0.71\u20130.93] vs. 0.68 [0.55\u20130.83]) and wide confidence intervals. Negative post-test probability remained high (16.7% vs. 14.0%). Conclusion Antenatal placental assessment may improve identification of RFM pregnancies at highest risk of adverse pregnancy outcome but further work is required to understand and refine currently available outcome definitions and diagnostic techniques to improve clinical utility.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53247780,"openaccessinfo":{"externalids":{"MAG":"2898612878","ACL":null,"DOI":"10.1371\/journal.pone.0206533","PubMedCentral":"6218043","ArXiv":null},"license":"CCBY","url":"https:\/\/storage.googleapis.com\/plos-corpus-prod\/10.1371\/journal.pone.0206533\/1\/pone.0206533.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210216%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210216T150802Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Glutathione, a low molecular mass thiol compound, is considered a vital biomarker for various disease and cancers owing to the variation in the level of GSH from its normal level in the micromolar to millimolar range in biological fluids and cells. Thus, it is of foremost importance to confirm the accurate and reliable concentration of it in order to provide appropriate treatments to patients. Nanostructure modified electrochemical sensors provide a sensitive, fast, and economic remedy for glutathione analysis. This short review is focused on the latest developments in nanostructure-based sensors from 2012 onward.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":101807162,"openaccessinfo":{"externalids":{"MAG":"2232723046","ACL":null,"DOI":"10.1039\/C5AY03140K","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An unsteady fully three-dimensional model of Lake Binaba (a shallow small reservoir) in semi-arid Upper East Region of Ghana has been developed to simulate its temperature dynamics. The model developed is built on the Reynolds Averaged Navier\u2013Stokes (RANS) equations, utilizing the Boussinesq approach. As the results of the model are significantly affected by the physical conditions on the boundaries, allocating appropriate boundary conditions, particularly over a water surface, is essential in simulating the lake's thermal structure. The thermal effects of incoming short-wave radiation implemented as a heat source term in the temperature equation, while the heat fluxes at the free water surface, which depend on wind speed, air temperature, and atmospheric stability conditions are considered as temperature boundary condition. The model equations were solved using OpenFOAM CFD toolbox. As the flow is completely turbulent, which is affected by the complex boundary conditions, a new heat transfer solver and turbulence model were developed to investigate the spatial and temporal distribution of temperature in small and shallow inland water bodies using improved time-dependent boundary conditions. The computed temperature values were compared with four days of observed field data. Simulated and observed temperature profiles show reasonable agreement where the root mean square error (RMSE) over the simulation period ranges from 0.11 to 0.44 \u00b0C in temporal temperature profiles with an average value of 0.33 \u00b0C. Results indicate that the model is able to simulate the flow variables and the temperature distribution in small inland water bodies with complex bathymetry.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":18309147,"openaccessinfo":{"externalids":{"MAG":"2289823604","ACL":null,"DOI":"10.3390\/W8030084","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The reaction of antigen-dependent E-rosette formation with the hemolytic streptococcal antigen in erysipelas patients is indicative of the ambiguous role of the specific immunological transformation of the body in respect of the infective agent antigens in different clinical forms of the disease and is of prognostic importance as regards the chronic transformation of the infectious process and the development of the relapses of the disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23615352,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This patient is a 64 year old male with a PMH of depression, anxiety, COPD, gastritis, and previous right inguinal hernia repair who presented to the emergency room with one day of right groin pain that occurred suddenly the night before.\u00a0 He has never experienced pain like this before and over the counter analgesics did not relieve the pain.\u00a0 Patient states that the pain is associated with a small budge in the right groin that is tender to palpation [1]. On physical exam patient had a soft and non-tender abdomen.\u00a0 An exquisitely tender 2cm x 2cm palpable nodule in the right groin was noted.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":81109177,"openaccessinfo":{"externalids":{"MAG":"2902971599","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The adsorption equilibria of propionic acid and glyoxylic acid on alumina are investigated experimentally and theoretically in this study. Alumina was used as the adsorbent. The period of achieving the equilibrium state and the effects of the amount of adsorbent, temperature, and initial acid concentration were investigated experimentally. Langmuir, Freundlich, and Temkin adsorption isotherm equations are fitted well with the experimentally measured data. It was found that the equilibrium isotherms depended on the initial acid concentration significantly. The Langmuir isotherm was found to best represent the data for both of the acids. The pseudosecond-order model, intraparticle diffusion model, and Elovich model were applied to experimental data. The adsorption of both acids followed pseudosecond-order kinetics. Diffusion is not the only rate-controlling step.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":101997052,"openaccessinfo":{"externalids":{"MAG":"2325759409","ACL":null,"DOI":"10.1021\/JE2000765","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As a member of the nuclear receptor superfamily, the farnesoid X receptor (FXR) is a bile acid activated transcription factor. FXR is involved in many important metabolic processes and serves as a promising therapeutic target for nonalcoholic steatohepatitis (NASH). Since discovered, the first non-steroidal FXR agonist GW4064 has been widely used to explore the biological functions of FXR, however, the low pharmacokinetic limited its further clinical application. In current study, we designed a series of substituted isothiazoles as new FXR agonists. Among them, five compounds exhibited better FXR agonistic activity than GW4064. Specially, the most potent compound S5 possessed better pharmacokinetic profile and in vivo potency than lead compound.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252132835,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.4189786","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The report examines the attitudes, expectations and strategies of agencies working in aged care in South Australia in 2016. It sets out to document the business conditions and perceived opportunities affecting the sector at a time of considerable transition, with a view to establishing a baseline of information that permits the monitoring of change over time, and helps inform both business growth and the formation of government policy. The data presented in this report represents a unique set of insights into South Australia's aged care sector at a time when it prepares for, and experiences, change. The data presented here was collected from February to May 2016 via an on-line survey sent to the CEOs of identifiable providers of aged care services in the state. This data collection will be repeated over the coming years to provide a snapshot of both change and emerging issues and accompanies research into the perspectives of aged care consumers in South Australia in 2016.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":78111981,"openaccessinfo":{"externalids":{"MAG":"2522032638","ACL":null,"DOI":"10.4225\/50\/57D645958EFCB","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Following a call from the World Health Organization in 2017 for a dashboard to monitor immunization coverage equity in line with the 2030 Agenda for Sustainable Development, this study proposes a new methodology and toolkit for measuring and tracking multi-dimensional equity in vaccine coverage, economic impact, and health outcomes. Methods: The Vaccine Economics Research for Sustainability & Equity (VERSE) composite vaccination equity assessment metric is derived from literature on the measurement of socioeconomic equity combined with measures of direct unfairness in healthcare access. The metric takes the form of a concentration index of vaccination coverage, where instead of ranking individuals by income, individuals are ranked by multi-dimensional unfairness in access. The direct unfairness ranking variable is the predicted vaccination coverage from a logistic model based upon multiple dimensions of fair and unfair sources of variation in vaccination coverage. Fair sources of variation in coverage may include whether the child is underage to receive the vaccine according to the national immunization schedule. Unfair sources of variation may include sex of the child, maternal education, or socioeconomic status. Regression decomposition is applied to determine the relative share each unfair dimension has on overall inequality in vaccination status. These methods are applied to the most recent National Family Health Survey (NFHS) from 2015-2016 in India to assess the equity in fully immunized for age vaccination coverage and zero-dose status. Equity results are computed by state and nationally and compared with coverage to produce an equity-coverage plane. Results: The multi-dimensional equity measure in is 0.105 (SE: 0.003) and 0.068 (SE: 0.005) for zero-dose status and fully immunized for age respectively. The most disadvantaged quintile is therefore 10.5% more likely to be zero-dose than the most advantaged quintile or 6.8% less likely to be fully immunized. The primary driver of unfair disadvantage in zero-dose status and fully immunized status, respectively, is maternal education accounting for 31.4% and 18.9% of observed inequality, followed by socioeconomic status contributing 15.9% and 14.9%, and health insurance coverage contributing 7.0% and 4.16%. Conclusions: Our work builds upon existing methods and toolkits by providing a standardized method for measuring equity across multiple dimensions. It also allows policymakers to determine the relative magnitude of drivers of overall equity in vaccine outcomes rather than only the drivers of socioeconomic or unidimensional equity. Additionally, the toolkit expands the available outcomes for inequity analysis from coverage to include financing and health outcomes. This framework could be adapted to track equitable progress toward Universal Health Coverage (UHC) beyond the vaccine space. Funding: The Vaccine Economics Research for Sustainability & Equity (VERSE) project is funded by the Bill & Melinda Gates Foundation under award INV-003813 Declaration of Interest: None to declare. Ethical Approval: The Vaccine Economics Research for Sustainaability & Equity (VERSE) project, under which this study falls, obtained IRB approval from the Johns Hopkins Bloomberg School of Public Health IRB (IRB00014999).","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":239997272,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.3945450","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Quality indicators have become increasingly important in the healthcare sector. Data from a trauma registry (TR) should be accurate and reliable as they are used to describe and evaluate (the quality of) trauma care. Objective To investigate the reliability of injury coding, injury severity scoring and survival status in a regional TR. The feasibility of the format that was developed for this study was also investigated. Methods A random sample, without replacement, was taken from the TR of a Dutch regional trauma care network. All 343 patients in the sample were then recoded by another trauma registrar (rater). Reliability was expressed in the percentage agreement between the raters. Results In the total study sample of 333 patients, the reliability of the number of Abbreviated Injury Scale (AIS) codes was substantial (intraclass correlation coefficient (ICC)=0.70); and the reliability of the Injury Severity Score (ISS) (ICC=0.84) and survival status were 'almost perfect' (Cohen's \u03ba=0.82). Both raters had given 129 patients one AIS code. The reliability of the body region of the AIS was 'almost perfect' (Cohen's \u03ba=0.91); and the reliability of the severity of the injury and the ISS were 'almost perfect' (weighted \u03ba=0.88 and ICC=0.90). The reliability of the ISS in the patients who were assigned at least two AIS codes (n=128) was 'almost perfect' (ICC=0.86). The reliability of the number of AIS codes and the number of body regions was 'moderate' (ICC=0.56 and Cohen's \u03ba=0.52). Conclusions The reliability of injury coding in a regional trauma registry was 'substantial' and the reliability of the ISS and survival status was 'almost perfect'. The format and design of this study were feasible and could be used to investigate the quality of (trauma) registries.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":23775428,"openaccessinfo":{"externalids":{"MAG":"2102924261","ACL":null,"DOI":"10.1136\/bmjqs-2013-001888","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper we present advancements in control and trajectory generation for agile behavior in bipedal robots. We demonstrate that Whole-Body Operational Space Control (WBOSC), developed a few years ago, is well suited for achieving two types of agile behaviors, namely, balancing on a high pitch split terrain and achieving undirected walking on flat terrain. The work presented here is the first implementation of WBOSC on a biped robot, and more specifically a biped robot with series elastic actuators. We present and analyze a new algorithm that dynamically balances point foot robots by choosing footstep placements. Dealing with the naturally unstable dynamics of these type of systems is a difficult problem that requires both the controller and the trajectory generation algorithm to operate quickly and efficiently. We put forth a comprehensive development and integration effort: the design and construction of the biped system and experimental infrastructure, a customization of WBOSC for the agile behaviors, and new trajectory generation algorithms. Using this custom built controller, we conduct, for first time, an experiment in which a biped robot balances in a high pitch split terrain, demonstrating our ability to precisely regulate internal forces using force sensing feedback techniques. Finally, we demonstrate the stabilizing capabilities of our online trajectory generation algorithm in the physics-based simulator and through physical experiments with a planarized locomotion setup.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":3779884,"openaccessinfo":{"externalids":{"MAG":"1940417524","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1501.02855"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With 50 billion connected in 2020 the Internet of Things (IoT) can be named the new 'big thing'. With its ability \nto get new insights in customer behavior and product performance it is a huge source of competitive advantage. \nThis study reveals the impact the Internet of Things can have on the new product development process. Many \nauthors have already done research in both fields but none of them clearly describes the relation the two topics can \nhave. Therefore this report integrates IoT in the front end of the new product development process. By studying \ndifferent literatures and interviewing some experts this paper tries to create a clear new product development \nmodel, in which IoT is integrated. The impact new products have on a firm's performance is big (30% of a firm's \nprofit). However some challenges arise in the current used methods. In order to find the bottlenecks in this process \nthe activities and success factors have been identified. It turned out that firms have the biggest influence in the predevelopment \nstages of the process, which is mainly concerned with identifying customer needs and generating \nideas. Besides that costs rise when moving further in the process. Therefore the front end is the phase in which \nfirms should put much effort in. However a challenge arises when analyzing this phase. It takes much time to come \nup with ideas, many ideas are needed, and many firms fail at identifying existing and potential customer needs. By \nintegrating the Internet of Things in products the way new products and services are created gets a new dimension. \nProducts contain sensors that are able to track product usage and provide performance data that couldn't be \ndiscovered before. This ability adds a new stage to the front of the well-known Stage-gate\u00ae model: the data \ncollection stage. Sensors in new products are the new source of continuous product and service improvement as it \ncan gather real-time data. The result of the addition of this stage is that the Stage-Gate\u00ae transforms from a straight \nmodel to a virtuous model.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":54976480,"openaccessinfo":{"externalids":{"MAG":"2460045873","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo analyze available literature data on the methods of colon recanalization in patients with acute malignant obstructive colonic obstruction.\n\n\nMATERIAL AND METHODS\nWe retrospectively analyzed literature data on the treatment of acute neoplastic colonic obstruction.\n\n\nRESULTS\nWe reviewed available national and foreign literature data on various methods of colon recanalization including various modern and hybrid techniques.\n\n\nCONCLUSION\nMethods of colon recanalization with subsequent stenting are the most optimal for preoperative decompression of colon. These measures are effective and allow postponing radical surgery or avoiding it altogether without worsening the prognosis of the underlying pathology. However, there is a small amount of literature data on modern hybrid methods of recanalization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259154854,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.17116\/hirurgia202306186","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Back pain is a kind of discomfort that frequently develops during pregnancy, especially among pregnant women in late pregnancy or those with a history of back pain in previous pregnancy. Prenatal yoga can relief back pain discomfort since it promotes good posture and stretch the spine's central nervous system. This study aims to determine the effect of yoga exercise on back pain among pregnant women in the third trimester.This was a pre-experimental study with one group pretest posttest design. The current study involved 30 pregnant women in the third trimester, who were assigned into the treatment group (participated in prenatal yoga exercise) and the control group (did not participate in prenatal yoga exercise), consisting of 15 samples, respectively. The study instrument applied here was Faces Pain Scale-Revised a questionnaire (FPS-R). It was found that there was a significant effect of prenatal yoga exercise to relief back pain among pregnant women in the third trimester (p<0.05). It can be concluded that prenatal yoga was beneficial for relieving back pain among pregnant women in the third trimester. Thus, prenatal yoga technique is considered an appropriate method for supproting the succes of pregnancy","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259836741,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose\nIn general, literature recognises that co-creative experiences add value to the tourism experience, yet empirical research within food-and-wine context remains scarce. This study aims to analyse the tourists' perceptions of the co-creation construct, their food-and-wine tourism experiences and their willingness to actively co-create in this type of experiences.\n\n\nDesign\/methodology\/approach\nDeparting from general co-creation theoretical concepts, this research explores how they can be applied in a specific food-and-tourism context. The end goal is to formulate a model that can be applied by food-and-wine managers when they create their tourism experience. A convenience sample of 19 tourists composed by 1 focus group (5 participants) and 14 face-to-face semi-structured interviews provided data for the qualitative research to explore tourists' perceptions of co-creation and how these perceptions can be used to create engaging and successful food-and-wine experiences.\n\n\nFindings\nResults reveal that co-creation is perceived by tourists as one or a combination of seven categories: social interaction, novelty, creativity, social sustainability, environmental awareness, enjoyment and memorable experiences. Respondents have participated in food-and-wine activities while travelling as a complement to their tourism experience displaying more willingness to actively participate in food rather than wine experiences.\n\n\nResearch limitations\/implications\nThis study is exploratory in nature which makes the data not generalisable. The findings need further quantitative validation. Although the food-and-wine experiences were created based on existing experiences, they are composed of a different number of stages (without standardisation), which may make further statistical analysis (comparisons) difficult.\n\n\nPractical implications\nBy conceptualising the co-creation construct, tourism managers may use the outcome of this study to turn their experiences more environmentally friendly and to improve the creative process of the experiences. The research findings not only emphasise the significance of understanding tourists' co-creation conceptualisation, but also indicate the importance of integrating creativity and environmental awareness dimensions into experiences. Particularly, the study develops a theoretical model supportive of the co-creation dimensions that can be applied on food-and-wine tourism contexts.\n\n\nOriginality\/value\nThis study fills a gap in the literature between co-creation in tourism and its application in food-and-wine settings by highlighting the significance that co-creation has in developing tourism business experiences.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":214100901,"openaccessinfo":{"externalids":{"MAG":"3008681645","ACL":null,"DOI":"10.1108\/tr-01-2019-0026","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/repositorio.utad.pt\/bitstream\/10348\/10205\/1\/Food-and-wine%20experiences%20towards.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The process of instructing the sportsmen has always been a complex and thorough activity, that requests profundity, professional sensitivity and bonding. The main characters in this process are played by managers, coaches, trainers, methodists, psychologists, sociologists, technicians who establish and hand over theoretical knowledge, building abilities for the sportsmen. In this way is being created the environment for instructing and highlighting the physical, technical, tactical and psychic potential of the participants in competitions. The preparation process of the sportsmen is more and more headed towards the integral and deep internalization of the instructive components, based on the interconnections between the elements of the modern sporting training.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":112008987,"openaccessinfo":{"externalids":{"MAG":"2261344398","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A wheel is a graph made of a cycle of length at least 4 together with a vertex that has at least three neighbors in the cycle. We prove that the problem whose instance is a graph G and whose question is \"does G contain a wheel as an induced subgraph\" is NP-complete. We also settle the complexity of several similar problems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264613818,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nCholecystectomy is the most commonly performed procedure in general surgery. However, bile duct injury is a rare but still one of the most common complications. These injuries sometimes present variably after primary surgery. Timely detection and appropriate management decrease the morbidity and mortality of the operation.\n\n\nMETHODS\nFive cases of iatrogenic bile duct injury (IBDI) were managed at the Department of Surgery, First Affiliated Hospital, Xi'an Jiaotong University. All the cases who underwent both open and laparoscopic cholecystectomy had persistent injury to the biliary tract and were treated accordingly.\n\n\nRESULTS\nRecovery of the patients was uneventful. All patients were followed-up at the surgical outpatient department for six months to three years. So far the patients have shown good recovery.\n\n\nCONCLUSIONS\nIn cases of IBDI it is necessary to perform the operation under the supervision of an experienced surgeon who is specialized in the repair of bile duct injuries, and it is also necessary to detect and treat the injury as soon as possible to obtain a satisfactory outcome.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27000979,"openaccessinfo":{"externalids":{"MAG":"163220338","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract 417 Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that is characterized by features of both a myeloproliferative neoplasm and a myelodysplastic syndrome. Here, we analyzed 81 CMML cases (45 CMML-1, 36 CMML-2). In chromosome banding analysis 59\/76 (77.6%) patients showed a normal karyotype (data not availabel in 5 cases). Recurrent chromosome aberrations were trisomy 8 (n=6; 7.9%), monosomy 7 (n=3; 3.9%), and loss of the Y-chromosome (n=5; 6.6%). Fluorescence in situ hybridization (FISH) detected the deletion of one allele of the TET2 gene in 4\/71 cases (5.6%). Thus, the majority of cases can not be genetically characterized by these techniques. Therefore, we applied next-generation sequencing (NGS) technology to investigate 7 candidate genes, represented by 43 PCR-products, at known mutational hotspot regions, i.e. CBL (exons 8 and 9), JAK2 (exons 12 and 14), MPL (exon 10), NRAS (exons 2 and 3), and KRAS (exons 2 and 3). In addition, complete coding regions were analyzed for RUNX1 (beta isoform) and TET2 . NGS was performed using 454 FLX amplicon chemistry (Roche Diagnostics Corporation, Branford, CT). The median number of base pairs sequenced per patient was 9.24 Mb. For each target gene a median of 911 reads was generated (coverage range: 736-fold to 1606-fold). This approach allowed a high-sensitive detection of molecular mutations, e.g. detecting the JAK2 V617F mutation down to 1.16% of reads. In total, 146 variances were detected by this comprehensive molecular mutation screening (GS Amplicon Variant Analyzer software version 2.0.01). In 80.4% of variances consistent results were obtained after confirming NGS mutations with melting curve analysis and conventional sequencing. In the remaining discrepant variances (19.6%) NGS deep-sequencing outperformed conventional methods due to the higher sensitivity of the platform. After excluding 19 polymorphisms or silent mutations 127 distinct mutations in 61\/81 patients (75.3%) were detected: CBL : n=21 point mutations and one deletion (18 bp) found in 20 cases (24%); JAK2 : n=8 mutations (V617F) found in 8 cases (9.8%); MPL : no mutations found; NRAS : n=23 mutations found in 18 cases (22.2%); KRAS : n=12 mutations found in 10 cases (12.3%); RUNX1 : n=6 point mutations and one deletion (14 bp) found in 7 cases (8.6%); and TET2 : n=49 point mutations and 6 deletions (2-19 bp; 5\/6 out-of-frame) found in 41 cases (50.6%). Furthermore, in 21 TET2 -mutated cases 11 mutations previously described in the literature were detectable, whereas 28 cases carried novel mutations (n=28). In the cohort of TET2 -mutated cases 17\/41 (41.3%) patients harbored TET2 abnormalities as sole aberration. Interestingly, CBL mutations were found to be significantly associated with TET2 mutations (Fisher9s exact test, p=0.008). In 17 of 20 (85.0%) CBL -mutated cases TET2 abnormalities were concomitantly observed. In contrast, no significant associations were found between any of the point mutations or deletions and the karyotype. There were also no associations observed between molecular aberrations and the diagnostic categories CMML-1 and CMML-2. With respect to clinical data a trend for better outcome was seen for patients that carried either or both TET2 and CBL mutations (median OS 130.4 vs. 17.3 months, alive at 2 yrs: 72.0% vs. 43.9%; p=0.13). In conclusion, 75.3% of CMMLs harbored at least one molecular aberration. In median 2 mutations per case were observed. Compared to limited data from the literature we detected not only a higher frequency of CBL mutations, but also add data on novel TET2 mutations. In particular, comprehensive NGS screening here for the first time has demonstrated its strength to further genetically characterize and delineate prognostic groups within this type of hematological malignancy. Disclosures: Kohlmann: MLL Munich Leukemia Laboratory: Employment. Grossmann: MLL Munich Leukemia Laboratory: Employment. Haferlach: MLL Munich Leukemia Laboratory: Equity Ownership. Kazak: MLL Munich Leukemia Laboratory: Employment. Schindela: MLL Munich Leukemia Laboratory: Employment. Weiss: MLL Munich Leukemia Laboratory: Employment. Dicker: MLL Munich Leukemia Laboratory: Employment. Schnittger: MLL Munich Leukemia Laboratory: Equity Ownership. Kern: MLL Munich Leukemia Laboratory: Equity Ownership. Haferlach: MLL Munich Leukemia Laboratory: Equity Ownership.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90204016,"openaccessinfo":{"externalids":{"MAG":"2566841786","ACL":null,"DOI":"10.1182\/BLOOD.V114.22.417.417","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An operator version of the stokeslet method in the theory of creeping flow is suggested. The approach is analogous to the zero-range potential one in quantum mechanics and is based on the theory of self-adjoint operator extensions in the space L2 and in the Pontryagin's space with an indefinite metric. The problem of Stokes flow in two channels connected through a small opening is considered in the framework of this approach. The picture of streamlines for such flow is obtained. The existence of infinite sequence of eddies is shown.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250746624,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0031-8949\/47\/5\/007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This chapter explores the promotion of the rule of law. In drafting and publishing Restatements of Foreign Relations Law, both the American Law Institute and the reporters have understood the projects as contributing to the rule of law at the international level, at the domestic level, or both. There are at least three distinct ways that these Restatements might promote the rule of law. First, they might do so by clarifying the content of the law. Second, the Restatements might contribute to the development of new legal rules, specifically to the evolution and consolidation of customary international law. Finally, the Restatements might promote the rule of law by promoting compliance with the law. Ultimately, the Third and Fourth Restatements have taken quite different approaches to promoting the rule of law. To some extent these different approaches are a consequence of changes in the legal landscape over the past three decades. They also reflect different choices that the reporters and the American Law Institute have made about how to carry out the project of restating foreign relations law.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":226365048,"openaccessinfo":{"externalids":{"MAG":"3093615071","ACL":null,"DOI":"10.1093\/oso\/9780197533154.003.0025","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/repository.law.umich.edu\/cgi\/viewcontent.cgi?article=1157&context=book_chapters","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the prevalence of the late onset dementia by 50%. After two decades of lack of success in dementia drug discovery and development, and knowing that worldwide, currently 36 million patients have been diagnosed with Alzheimer's disease, a number that will double by 2030 and triple by 2050, the World Health Organization and the Alzheimer's Disease International declared that prevention of cognitive decline was a 'public health priority.' Numerous longitudinal studies and meta-analyses were conducted to analyze the risk and protective factors for dementia. Among the 93 identified risk factors, seven major modifiable ones should be considered: low education, sedentary lifestyle, midlife obesity, midlife smoking, hypertension, diabetes, and midlife depression. Three other important modifiable risk factors should also be added to this list: midlife hypercholesterolemia, late life atrial fibrillation, and chronic kidney disease. After their identification, numerous authors attempted to establish dementia risk scores; however, the proposed values were not convincing. Identifying the possible interventions, able to either postpone or delay dementia has been an important challenge. Observational studies focused on a single life-style intervention increased the global optimism concerning these possibilities. However, a recent extensive literature review of the randomized control trials (RCTs) conducted before 2014 yielded negative results. The first results of RCTs of multimodal interventions (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, Multidomain Alzheimer Prevention Study, and Prediva) brought more optimism. Lastly, interventions targeting compounds of beta amyloid started in 2012 and no results have yet been published.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":1423430,"openaccessinfo":{"externalids":{"MAG":"2526670877","ACL":null,"DOI":"10.4082\/kjfm.2016.37.5.263","PubMedCentral":"5039116","ArXiv":null},"license":"CCBYNC","url":"http:\/\/www.kjfm.or.kr\/upload\/pdf\/kjfm-37-263.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Purpose - \u2013 The purpose of this paper is to analyse the effect of financial integration on several macroeconomic variables from a global perspective. Design\/methodology\/approach - \u2013 The authors apply a cointegrated vector autoregression model using quarterly data for 1980-2009. Analysing the interactions of globally aggregated measures capturing cross-border financial transactions, monetary liquidity, output, consumer and commodity prices, the authors focus on the dissection of short-run and long-run dynamics. Findings - \u2013 The authors find that increasing financial integration has a positive impact driving GDP. The authors also find evidence of two-way causality between commodity prices and financial flows. The results suggest that commodity prices are driven by financial integration and the gap between the dynamics of commodity prices and financial flows is closed by global liquidity injected by central banks. Originality\/value - \u2013 The paper contributes to the empirical literature by analysing the overall impact of global financial integration and of global liquidity on global macroeconomic variables in a unified framework.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":155998452,"openaccessinfo":{"externalids":{"MAG":"2208340371","ACL":null,"DOI":"10.1108\/JES-02-2015-0026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of this study was to evaluate onion production systems in four municipalities along the Niger River. A cross-sectional survey was carried out among seventy-five onion producers distributed over ten perimeters. The results obtained reveal that onion is mainly grown by women (95%). 70% of the farmers own the farmed land, 20% rent and 10% borrow. The cultivation takes place between September and March. The cultivated varieties are 'Galmi violet' and 'Goth\u00e8ye white', Onions are essentially transformed into Gabou, a traditional condiment. The areas exploited are generally less than half a hectare. Irrigation relies mainly on the gravity system. NPK fertilizer and urea in combination with manure are the most commonly used. For phytosanitary treatments, producers use pesticides and\/or natural products based on aqueous extract. At harvest time, the price per 100 kg bag varies from 8 000 to 15 000 FCFA (12 to 23 \u20ac) and from 40 000 to 50 000 FCFA (61 to 76 \u20ac) after four months of storage. The average production cost per hectare is 1 208 564 FCFA (1844 \u20ac) and that of the net margins 551 857 FCFA (840 \u20ac). There is a low correlation between strong investments and net margins. The major constraints faced by producers are the high cost of agricultural inputs, the rapid drying up of water points, limited access to credit, the straying of animals, the collapse of prices during the harvest period and the difficulties of farming storage and conservation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55313063,"openaccessinfo":{"externalids":{"MAG":"2807475986","ACL":null,"DOI":"10.19044\/ESJ.2018.V14N15P175","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A checklist of the trees, shrubs and Hanes of Catapu, Cheringoma District, Mozambique, is presented. Floristically the study area falls within the Swahilian\/Maputaland Regional Transition Zone. In total, 238 woody species and infraspecific taxa have been recorded, representing 59 families and 167 genera. Most species (64%) occur both to the north and south of the study area. 26% have their core distribution in the Swahilian Regional Centre of Endemism, 4% have a more southerly distribution. 14 are endemic to the Swahilian\/Maputaland Regional Transition Zone and two near-endemic, extending into the Zambezian Regional Centre of Endemism only along the Zambezi River Valley as far west as Kariba. The checklist includes the Sena names for 191 species, 77 of which are recorded for the first time. Comparisons of the Catapu checklist are made with other checklists.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62831521,"openaccessinfo":{"externalids":{"MAG":"1521912989","ACL":null,"DOI":"10.4102\/ABC.V37I1.303","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Change detection based on remote sensing data has become a highly frequented field of research with multiple applications for practical use. In this study, a fully-automatic change detection method based on SAR amplitude images is proposed. This method aims at the detection of small-scaled abrupt changes which are caused for example by different kinds of vehicles or building sites. As dataset, a time series (about half a year) of TerraSAR-X images covering the scene of Greding (Germany) and surroundings was used. From this dataset, an amplitude based activity map was calculated. For evaluation purpose, this method is compared with the CoVAmCoh analysis, which represents a complementary approach for SAR change detection. In a final step, first evaluations concerning the change categorization are considered.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":10695619,"openaccessinfo":{"externalids":{"MAG":"1976320505","ACL":null,"DOI":"10.1109\/IGARSS.2012.6350584","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although previous research has found the disciplinary model of correctional boot camps to be ineffective in reducing recidivism, the impact of a rehabilitative model is still unclear. The current study addresses this issue through an outcome evaluation of Penn-sylvania's Motivational Boot Camp Program, which uses a multidimensional approach to its rehabilitative programming. The authors predict that this program model should be more effective than traditional prison in reducing recidivism and that this effect will be particularly strong for certain high-risk offenders (i.e., those who are young and\/or have a prior criminal record). The results from their logistic regression analyses indicate no significant differences in the recidivism of offenders graduating from the boot camp and those released from prison. However, tests for interactions indicate that this program performs better than prison for offenders with a prior record. This particular finding has important policy implications for targeting appropriate offenders for such programs.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":145084256,"openaccessinfo":{"externalids":{"MAG":"2096124683","ACL":null,"DOI":"10.1177\/0011128703252664","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this in vitro study was to compare the degradation of gemcitabine (2', 2'-difluorodeoxycytidine, dFdC), in Fresh Whole Blood (FWB) from humans, dogs, cats, and horses. A better understanding of the comparative degradation of gemcitabine may aid in the optimal design of therapeutic regimens in veterinary species. Fresh whole blood from humans, dogs, cats, and horses was spiked with dFdC and plasma was analyzed for dFdC and 2', 2'-difluorodeoxyuridine (dFdU) by high performance liquid chromatography. In these species, there was an initial rapid degradation of dFdC with a concomitant proportional increase in dFdU. Degradation of gemcitabine appeared similar in humans, dogs, and horses (p>0.05) whereas metabolism was slower in the cat than human (p=0.014), dog (p=0.010), or horse (p=0.0015). Based on these in vitro findings, dosing schemes for humans, dogs, and horses may be similar. In contrast, gemcitabine degradation occurred more slowly in the cat; this difference may dictate a different dosing scheme for optimal response in this species.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70526773,"openaccessinfo":{"externalids":{"MAG":"1908258951","ACL":null,"DOI":"10.4172\/2157-7579.1000119","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Human cloning is a prospect the contributors to Clones and Clones view with varying degrees of alarm, calm, ambivalence, and not a little humor. Ranging from psychoanalyst Adam Phillips's case study of a child whose confusion of \"cloning\" and \"clothing\" expresses our mixed desire and terror of sameness, to Stephen Jay Gould's and Richard Dawkins's \"characteristically pithy and intelligent\" essays (Civilization); from William Ian Miller's analysis of the queasiness the subject elicits in many of us, to Martha Nussbaum's witty and elegiac fantasy of the cloning of a lost lover-this superb collection limns our beliefs and concerns about what it means to be human. The writers here, says the San Diego Union-Tribune, \"comprise an eclectic group, but their observations on the science and ethics of cloning, how it might fit into and affect human society and what the future might bring are just the sort of thinking that ...we need more of.\" Praise for Clones and Clones: \"A worthy exploration of a discomfiting topic.\" - Foreign Affairs \"Greatly aid[s] the cloning debate.\" - Washington Post \"The spectrum of authors and their varying perspectives in fact and fiction are assets to anyone who hopes to understand this broad issue and its vast cultural implications.\" - Publishers Weekly","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":142686777,"openaccessinfo":{"externalids":{"MAG":"1567126753","ACL":null,"DOI":"10.2307\/20049070","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"X-ray photoelectron spectroscopy has been used to measure the valence band offset of the InN\/BaTiO3 heterojunction. It is found that a type-I band alignment forms at the interface. The valence band offset (VBO) and conduction band offset (CBO) are determined to be 2.25 \u00b1 0.09 and 0.15 \u00b1 0.09 eV, respectively. The experimental VBO data is well consistent with the value that comes from transitivity rule. The accurate determination of VBO and CBO is important for use of semiconductor\/ferrroelectric heterojunction multifunctional devices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121471516,"openaccessinfo":{"externalids":{"MAG":"2024236197","ACL":null,"DOI":"10.1063\/1.2716994","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/wrap.warwick.ac.uk\/972\/1\/WRAP_King_Valance_INN_AIN.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"G-protein-coupled receptors are a major target for potential therapeutics; yet, a large number of these receptors couple to the Gi pathway, generating signals that are difficult to detect. We have combined chimeric G proteins, automated sample handling, and simultaneous 96-well fluorometric imaging to develop a high-throughput assay system for Gi signaling. The chimeric G proteins alter receptor coupling so that signaling can occur through Gq and result in mobilization of intracellular calcium stores. An automated signaling assay device, the fluorometric imaging plate reader (FLIPR), can simultaneously measure this response in real time in 96-well microplates, allowing two people to process more than 10,000 points per day. We used the chimeric G protein\/FLIPR system to characterize signaling by the Gi-coupled human opioid receptors. We show that the mu, delta, and kappa opioid receptors and the related nociceptin receptor, ORL1, each couple to Galphaqi5, Galphaqo5, and Galpha16 (Galphaqi5 and Galphaqo5 refer to Galphaq proteins containing the five carboxyl-terminal amino acids from Galphai and Galphao, respectively) and that different receptor\/G protein combinations show different levels of maximal activation. We tested 31 opioid ligands for agonist activity at the opioid receptors (124 ligand-receptor combinations); all 31 activated at least one receptor type, and several activated multiple receptors with differing potencies. This high-throughput assay could be useful for dissecting the complex ligand-receptor relationships that are common in nature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28748964,"openaccessinfo":{"externalids":{"MAG":"1978997108","ACL":null,"DOI":"10.1006\/ABIO.1999.4061","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This research explores the experiences of women journalists working in sports, focusing on four areas of potential problems: condescension in the workplace, equal opportunity in the workplace, perceived performance, and job satisfaction. The results of the study indicate that although females are appearing in sports newsrooms across the nation in increasing numbers, women feel they are, in many ways, invisible to their colleagues, expected to know less and accept more menial assignments, while being the target of sexist language. In spite of the discrimination, approximately three-fourths of the respondents said that they are satisfied with their jobs.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144278771,"openaccessinfo":{"externalids":{"MAG":"2076119307","ACL":null,"DOI":"10.1177\/107769909507200411","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Hot Mix Asphalt (HMA) is the most commonly used in Malaysia for highways, interstates and roads due to its flexibility, economical, strong and provide safe riding quality for road users. Over the years, the increase of damage on pavement roads in Malaysia has become a severe issue although the road did not achieve its design life. Hence, to reduce damage and defect, an improvised road pavement structures is needed. Various studies have been conducted to identify the new materials that can be used as a replacement in hot mix asphalt. In this research, the purpose is to evaluate the performance of eggshell as coarse aggregate replacement in hot mix asphalt. The gradation for aggregate used in this mixture is AC14. The weight for total mixing of the aggregates used is 1200g while the grade for bitumen is 60\/70. The samples were mixed with eggshell in the various percentages of 0%, 5%, 10%, 15% and 20% by total weight of aggregate size 5mm. The laboratory tests carried out to determine the properties of aggregates included, aggregate impact value and aggregate crushing value. Besides, penetration and softening point were also performed to determine the properties of bitumen. Several types of test were conducted towards the samples, which are Marshall Test, Indirect Tensile Strength and Cantabro Test. The results exhibit that the conventional asphalt mixture is more effective than modified asphalt mixture. The replacement of eggshell as coarse aggregate was not enough improvement to the performance of asphalt pavement as the performance of conventional mixture is more stable than modified mixture.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":236633442,"openaccessinfo":{"externalids":{"MAG":"3167154032","ACL":null,"DOI":"10.15282\/CONSTRUCTION.V1I1.6180","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of formulating aciclovir occusert was to prolong the drug residence time after ocular administration to achieve the controlled release of drug. Aciclovir is a antiviral agent and its use in the treatment of viral infections like herpes simplex infections. Ocular inserts were prepared by solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with polyethylene glycol 400 as the plasticizer.DSC and IR spectral studies were performed to confirm the interaction of drug and polymers in formulation. The ocusert were evaluated for their physical and chemical and in vitro \u2013 release characteristics. The developed formulation was stable sterile and non irritant. The final formulation F2 was subjected to UV irritation for sterilization. In the present work it was concluded that the F2 formulation shows 99.16% controlled release upto 8 hrs when compared to other formulations.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":100493020,"openaccessinfo":{"externalids":{"MAG":"2583027629","ACL":null,"DOI":"10.5958\/0974-360X.2016.00379.6","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Today, profound insight into the clotting and fibrinolytic systems during therapeutic thrombolysis is offered by a variety of laboratory assays. While the purpose of scientific investigations is to increase the knowledge on changes imposed by the mechanism of thrombolysis, the rationale for performing coagulation assays during thrombolytic therapy is to increase the safety of treatment. To make laboratory monitoring of thrombolytic therapy most effective, the main issues which should be solved should be defined. The main reasons for performing coagulation assays during and after thrombolytic therapy are: 1. To monitor the adjunctive anticoagulant therapy. 2. To detect potential bleeding hazards early, and 3. in case bleeding complications occur, to help to optimise of the therapeutic strategies to avoid excessive diagnostics. Most of the methods affording an insight into coagulation and fibrinolysis are not very helpful in terms of improved therapeutic safety. Too frequent repetition of assays is likewise superfluous. In our opinion, clinical routine monitoring should consist of red blood cell count, aPTT, and fibrinogen according to Clauss' method which should be repeated during the first 48 hours after initiation of therapy at 8- to 12-hour intervals. It must be mentioned in this respect that fibrinogen according to Clauss' method during thrombolytic therapy must be regarded an assay to estimate the global coagulation potential of the blood rather than to quantify fibrinogen levels. In our opinion, it is this that makes the Clauss' method superior to other methods of fibrinogen determination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43093373,"openaccessinfo":{"externalids":{"MAG":"2404893346","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gain an invaluable edge on how to specify, install and operate electrical heating systems for a broad range of industrial applications with the tips and suggestions provided in this book. Key features you'll put to immediate use include: Samples of specifications for many types of heating systems, previously unpublished empirical formulas for designing induction heating systems, thorough coverage of electrical pipe heating, and factory and field check-out instructions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":106887660,"openaccessinfo":{"externalids":{"MAG":"612125793","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Micro\/nano encapsulation technology has acquired considerable attention in the fields of drug delivery, biomaterial engineering, and materials science. Based on recent advances in chemical particle synthesis, we propose a primitive model of an encapsulation system produced by the self-assembly of Janus oblate spheroids, particles with oblate spheroidal bodies and two hemi-surfaces coded with dissimilar chemical properties. Using Monte Carlo simulation, we investigate the encapsulation system with spherical particles as encapsulated guests, for different densities. We study the anisotropic effect due to the encapsulating agent's geometric shape and chemical composition on the encapsulation morphology and efficiency. Given the relatively high encapsulation efficiency we find from the simulations, we believe that this method of encapsulation has potential practical value.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":94702120,"openaccessinfo":{"externalids":{"MAG":"2952182944","ACL":null,"DOI":"10.1039\/C2SM00005A","PubMedCentral":null,"ArXiv":"1112.3268"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Seventy-two bacterial strains were isolated from twenty various sources including soil, water, rotten fruits, vegetables etc. Preliminary screening for pectinase producing bacterial strains was done by well plate method and twenty-six bacterial strains gave zones on Minimum Salt (MS) medium supplemented with 0.2% pectin. Most of the isolates belonged to plant origin, either rotten fruits or vegetables due to high pectin presence as compared to other samples. Amongst the bacterial isolates, ZP-F5 and ZP-F6 gave the largest zone sizes i.e., 45 mm and 40 mm respectively. All selected strains were subjected to cellular, morphological and biochemical characterization. Polygalacturonase production by the selected strains was measured quantitatively by DNS method. Strain ZP-F5 and ZP-F6 were producing maximum amount of enzymes i.e., 1.85 U\/ml and 1.86 U\/ml respectively. Identification of pectinase producing bacteria was confirmed by amplification and sequencing of their 16S rDNA gene. The sequences obtained were BLAST which revealed that ZP-F5, ZP-F6, ZP-F14, ZP-F24 and ZP-F25 were found homologous to Bacillus. Whereas, ZP-F10, ZPF16 and ZP-F18 were homologous to Klebsiella veriicola, Brevibacillus laterosporus, Ewingella americana respectively. In the present study, other than Bacillus species some of the novel strains obtained like Klebsiella veriicola, Brevibacillus laterosporus, Ewingella americana, Providencia vermicola and Klebsiella oxytoca demonstrated significant levels of pectinolytic enzymes capable of hydrolyzing pectin.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":28030679,"openaccessinfo":{"externalids":{"MAG":"2588991070","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The relaxation time of a classical spin interacting with a large conduction-electron system is computed for a weak magnetic field, which initially drives the spin out of equilibrium. We trace the spin and the conduction-electron dynamics on a time scale, which exceeds the characteristic electronic scale that is set by the inverse nearest-neighbor hopping by more than five orders of magnitude. This is achieved with a novel construction of absorbing boundary conditions, which employs a generalized Lindblad master-equation approach to couple the edge sites of the conductionelectron tight-binding model to an external bath. The failure of the standard Lindblad approach to absorbing boundaries is traced back to artificial excitations initially generated due to the coupling to the bath. This can be cured by introducing Lindblad parameter matrices and by fixing those matrices to perfectly suppress initial-state artifacts as well as reflections of physical excitations propagating to the system boundaries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220381107,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2007.03655"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"According to some embodiments, an apparatus having a first sensor having a first adjustable lens and a second sensor having a second adjustable lens is disclosed. A controller is coupled to the first sensor and the second sensor. The controller is to cause the first sensor and the second sensor to operate independently in a first mode and is to cause the first motion sensor and the second motion sensor to operate interdependently in a second mode.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145952307,"openaccessinfo":{"externalids":{"MAG":"2935771607","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Connected societies require reliable measures to assure the safety, privacy, and security of members. Public safety technology has made fundamental improvements since the first generation of surveillance cameras were introduced, which aims to reduce the role of observer agents so that no abnormality goes unnoticed. While the edge computing paradigm promises solutions to address the shortcomings of cloud computing, e.g., the extra communication delay and network security issues, it also introduces new challenges. One of the main concerns is the limited computing power at the edge to meet the on-site dynamic data processing. In this paper, a Lightweight IoT (Internet of Things) based Smart Public Safety (LISPS) framework is proposed on top of microservices architecture. As a computing hierarchy at the edge, the LISPS system possesses high flexibility in the design process, loose coupling to add new services or update existing functions without interrupting the normal operations, and efficient power balancing. A real-world public safety monitoring scenario is selected to verify the effectiveness of LISPS, which detects, tracks human objects and identify suspicious activities. The experimental results demonstrate the feasibility of the approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":75135213,"openaccessinfo":{"externalids":{"MAG":"2928440829","ACL":null,"DOI":"10.1117\/12.2518999","PubMedCentral":null,"ArXiv":"1903.04563"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1903.04563","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Placenta accreta is one of the most severe anomalies of attachment, due to the high risk of massive bleeding. At present, the paradigm of organ-preserving delivery is laid. The implementation of this tactic is possible in the context of the introduction into the obstetric practice of patient blood management (PBM).Objective:to evaluate the effectiveness of blood preservation methods in the management and delivery of pregnant women with placenta placenta accrete.Materials and methods:The study group consisted of 59 pregnant women with placenta accreta in age from 20 to 40 years old (32,43 \u00b1 5,05), who were examined in \u00abScientific Medical Research Center of Obstetrics\". Clinical, special (ultrasound and magnetic pelvic magnetic resonance imaging) and laboratory methods were used. A program of preparation for delivery was developed using the principles of the PBM: treating anemia at the preoperative stage; a multidisciplinary operating team was prepared (two obstetricians, a surgeon, anesthesiologist and resuscitator, anesthetist, transfusionist, physician, who provides work for Cell Saver, laboratory assistant). Operational tactics included a bottom cesarean section using one of the methods of surgical prevention and arrest of bleeding - bilateral ligation of the internal iliac arteries (1st group) (19 women), temporary stop of blood flow in common iliac artery by means of vascular clamps Satinsky (18 patients \u2013 2ndgroup); bilateral overlay of turnstile harnesses on the base of the wide ligaments and the cervical-neck area, supplemented by a controlled balloon tamponade of the uterus (22 patients \u2013 3rd d group). The operation was carried out under conditions of intraoperative reinfusion of autoerythrocytes on the apparatus \"Cell-Saver 5\", donor FFP and erythrocyte component, tranexam preparations, rFVIIa (KoagilVII) were administered. In 80% of women, operations were performed under combined spinal-epidural anesthesia.Results:the lowest blood loss was detected in the 3rd group with compression complex hemostasis: 1286 \u00b1 510 ml. Accordingly, the volumes of infusion and transfusion therapy were also the smallest in this group. The volume of reinfused autoerythrocytes ranged from 260 ml to 1420 ml and averaged 801,7 \u00b1 414,18 ml with a hematocrit of 55-60%. Donor erythrocytes were transfused to only 27 patients in an average volume of 785,1 \u00b1 134,2 ml. rFVIIa (Koagil) was administered to four patients: three from the first group and one from the second group: a significant decrease in the speed and volume of bleeding was noted, and he performed an organ-sparing operation. Hysterectomy was performed on five women (8,77%). In the postoperative period was carried out antianemic therapy. The hospital stay averaged 7,9 \u00b1 1,8 days.Conclusion:The special role in the management and delivery of pregnant with placenta accreta plays the use of various PBM techniques , which include rational therapy of preoperative and postoperative anemia with modern iron preparations, rational surgical tactics, red blood cell autotransfusion, use of modern hemostatic agents and blood substitutes. A comprehensive multidisciplinary approach to this problem allows reducing blood loss, minimizing the volume of donor blood components and implementing organ-preserving tactics in a significant number of women.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":132974593,"openaccessinfo":{"externalids":{"MAG":"2925669991","ACL":null,"DOI":"10.21518\/2079-701x-2019-7-134-141","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.21518\/2079-701x-2019-7-134-141","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this commentary is to respond to Levine's (1994) critique of our earlier article (McClanahan & Holmbeck, 1992). We agree with Levine's argument that changes in the subscales of the Separation-Individuation Test of Adolescence (SITA; Levine, Green, & Millon, 1986) should be made based on both theoretical and statistical considerations. On the other hand, we also argue that attention needs to be paid to the content and construct validity of the SITA in future revisions of the measure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23242280,"openaccessinfo":{"externalids":{"MAG":"2001338014","ACL":null,"DOI":"10.1207\/S15327752JPA6201_16","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: This study aimed to determine the relationship of the container environment's type and condition to the existence of Aedes sp larvae in Tanjungpinang Timur District. Methods: An observational study with a cross-sectional approach involved 401 houses with containers in Tanjungpinang Timur District, Tanjungpinang City. Data on the existence of larvae was performed using the single larvae method. Data on container type and container environmental conditions (water pH, water temperature, air temperature, air humidity) and larvae's presence were collected by observing and measuring. Results: 863 containers were observed, 138 of them (15.99%) were found larvae of Aedes sp, containers inside the house (65.57%), and not closed (88.53%). The types of containers were controllable sites (95.13%), disposable sites (3.36%), and under controllable sites (1.51%). The measurement of water pH (76.13%) and water temperature (82.73%) of the containers were categorized as good. Container temperature 98.38% showed results with a range of unfavorable conditions ( 300C) and air humidity of 99.07% with a range ( 89.5%). Type, location, condition of container closure, water pH, water temperature, and air temperature of containers were related to larvae in Tanjungpinang Timur District (p-value <0.05), while the variable humidity was not related to the existence of larvae.\u00a0 Conclusion: Physical environmental factors strongly support the reproduction of DHF vectors in the East Tanjungpinang District. It is necessary to increase public knowledge and routine home eradication of mosquito nests (PSN), especially controllable site containers widely used as water reservoirs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234027029,"openaccessinfo":{"externalids":{"MAG":"3128367413","ACL":null,"DOI":"10.22146\/BKM.57738","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Semantic clones are program components with similar behavior, but different textual representation. Semantic similarity is hard to detect, and semantic clone detection is still an open issue. We present semantic clone detection via Probabilistic Software Modeling (PSM) as a robust method for detecting semantically equivalent methods. PSM inspects the structure and runtime behavior of a program and synthesizes a network of Probabilistic Models (PMs). Each PM in the network represents a method in the program and is capable of generating and evaluating runtime events. We leverage these capabilities to accurately find semantic clones. Results show that the approach can detect semantic clones in the complete absence of syntactic similarity with high precision and low error rates.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":210838781,"openaccessinfo":{"externalids":{"MAG":"3000805073","ACL":null,"DOI":"10.1109\/IWSC50091.2020.9047635","PubMedCentral":null,"ArXiv":"2001.07399"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was carried out in the experimental field and in unheated greenhouses of the Lithuanian Research Centre for Agriculture and Forestry Institute of Horticulture. The investigation aimed to evaluate the morphological features, amount of essential oil, and productivity of 10 basil (Ocimum basilicum L.) cultivars grown under different growing conditions. Studied cultivars were different according to morphological parameters, productivity, and the accumulation of essential oil. Most of the investigated parameters were influenced by growing conditions. Basil plants of cultivars Sweet Genovese and Toscano were determined to be the highest, and their height reached up to 70.5 cm. Cultivar Sweet Genovese was the most productive; its fresh herb mass per plant reached up to 0.71 kg under growing in the open field and greenhouse. Higher air temperature and constant watering of the soil in the greenhouse increased the accumulation of essential oils of basil. The biochemical analyses showed that the essential oil amount of 31% was higher when basils were grown in a greenhouse compared to an open field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251006815,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/plants11141896","PubMedCentral":"9324572","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2223-7747\/11\/14\/1896\/pdf?version=1658498673","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Neuropathic pain can be considered as a form of chronic stress that may share common neuropathological mechanism between pain and stress-related depression and respond to similar treatment. Ferulic acid (FA) is a major active component of angelica sinensis and has been reported to exert antidepressant-like effects; however, it remains unknown whether FA ameliorate chronic constriction injury (CCI)-induced neuropathic pain and the involvement of descending monoaminergic system and opioid receptors. Chronic treatment with FA (20, 40 and 80 mg\/kg) ameliorated mechanical allodynia and thermal hyperalgesia in von Frey hair and hot plate tasks, accompanied by increasing spinal noradrenaline (NA) and serotonin (5-HT) levels. Subsequent study suggested that treatment of CCI animals with 40 and 80 mg\/kg FA also inhibited spinal MAO-A levels. FA's effects on mechanical allodynia or thermal hyperalgesiawas blocked by 6-hydroxydopamine (6-OHDA) or p-chlorophenylalanine (PCPA) via pharmacological depletion of spinal noradrenaline or serotonin. Moreover, the anti-allodynic action of FA on mechanical stimuli was prevented by pre-treatment with beta2-adrenoceptor antagonist ICI 118,551, or by the delta-opioid receptor antagonist naltrindole. While the anti-hyperalgesia on thermal stimuli induced by FA was blocked by pre-treatment with 5-HT1A receptor antagonist WAY-100635, or with the irreversible mu-opioid receptor antagonist beta-funaltrexamine. These results suggest that the effect of FA on neuropathic pain is potentially mediated via amelioration of the descending monoaminergic system that coupled with spinal beta2- and 5-HT1A receptors and the downstream delta- and mu-opioid receptors differentially.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":30342416,"openaccessinfo":{"externalids":{"MAG":"2345286907","ACL":null,"DOI":"10.18632\/oncotarget.7973","PubMedCentral":"4991467","ArXiv":null},"license":"CCBY","url":"https:\/\/www.oncotarget.com\/article\/7973\/pdf\/","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Years ago, on the distant planet Krypton, a scientist discovers that his world faces total destruction. Before the planet explodes, he sends his only son into outer space. The child's rocket crashes on a farm in the middle of a Kansas cornfield. A farmer and his wife discover the child and the strange powers that lie in the tiny hands of this last son of Krypton.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":126748463,"openaccessinfo":{"externalids":{"MAG":"589872621","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A study was made of 162 persons with intermittent claudication who were observed for an average of 8.3 years. These were all the cases that evolved from a population cohort during 18 years of follow-up. They were essentially untreated until rest pain and tissue loss began. Only four progressed to major amputations and three to toe loss. A profile of the person developing intermittent claudication and gangrene in particular reveals a higher prevalence of diabetes and the cigarette habit, as well as hypertension and hypercholesteremia. The comorbidity and subsequent incidence of coronary disease, stroke, and congestive failure was high. Within eight years, almost half developed a major cardiovascular event and 20% of the men and 30% of the women were dead. This cardiovascular morbidity and mortality, as well as intermittent claudication, is predictable in the general population free of cardiovascular disease. Patients being considered for bypass surgery whose only complaint is claudication should be carefully evaluated for risk of cardiovascular morbidity.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":44793395,"openaccessinfo":{"externalids":{"MAG":"2061435656","ACL":null,"DOI":"10.1001\/ARCHSURG.1974.01360050087019","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Electrochemical determination of paracetamol (PCT) was successfully performed using carbon paste electrodes (CPEs) modified with treated coffee husks (CHt) or cellulose powder (Ce). Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their use. The electrochemical oxidation of PCT was investigated using square wave voltammetry (SWV) and cyclic voltammetry (CV). The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30% higher with CPE-Ce in comparison with the unmodified CPE, and this correlated with the higher hydrophilicity of the modified electrodes. Using SWV for the electrochemical analysis of PCT, carbon paste electrode modified with raw coffee husks (CPE-CHr) showed the presence of impurities at +0.27 V\/SCE, showing the interest in using pure cellulose for the present analytical application. Furthermore, CPE-Ce presented a higher real area compared to CPE-CHr, which explains the increase in the limit of saturation from 400 mg\/L to 950 mg\/L. The better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized tablets. The proposed method was successfully applied in the determination of PCT in commercialized tablets (Doliprane\u00ae 500) with a recovery rate close to 100%, and no interference with the excipients contained in the tablets analyzed was observed.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":103361050,"openaccessinfo":{"externalids":{"MAG":"2767864309","ACL":null,"DOI":"10.7569\/JRM.2017.634169","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Launched in 2014, Indonesia's national health insurance system (JKN) aimed to provide universal health coverage, including contraceptive services, to its population. We aim to evaluate the contribution of JKN to the overall spending for the family planning program in Indonesia.\u00a0 Methods: Data from the Indonesian Demographic Health Survey, Survey on Financial Flows for Family Planning, Indonesia Motion Tracker Matrix, World Population Prospect, and Indonesian ministries' budget accountability reports were entered into the CastCost Contraceptive Projection Tool to define budgetary allocation and spending for the family planning program at the national level in 2019.\u00a0 Results: Indonesia's family planning program in 2019 was financed mostly by the national budget (64.0%) and out-of-pocket payments (34.6%). There were three main ministries responsible for family planning financing: the National Population and Family Planning Board (BKKBN) (35.8%), the Ministry of Finance (26.2%), and the Ministry of Health (2.0%). Overall, JKN contributed less than 0.4% of the funding for family planning services in Indonesia in 2019. The majority of family planning spending was by public facilities (57.3%) as opposed to private facilities (28.6%).\u00a0 Conclusion: JKN's contribution to funding Indonesia's family planning programs in 2019 was low and highlights a huge opportunity to expand these contributions. A coordinated effort should be conducted to identify possible opportunities to realign BKKBN and JKN roles in the family planning programs and lift barriers to accessing family planning services in public and private facilities. This includes a concerted effort to improve integration of private family planning providers into the JKN program.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":3,"2024-22":1}},"corpusid":259653534,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.12688\/gatesopenres.14642.1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/gatesopenresearch.org\/articles\/7-105\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We have theoretically studied the charge transfer in glycine polypeptide using quantum mechanical models based on a tight-binding Hamiltonian approach. The charge-transfer integrals and site energies involved in the transport of positive charge through the peptide bond in glycine polypeptide have been calculated. The charge-transfer integrals and site energies have been calculated directly from the matrix elements of the Kohn-Sham Hamiltonian defined in terms of the molecular orbitals of the individual fragments of the glycine polypeptide. In addition to this, we have calculated the rate of charge transfer between a neighboring amino acid subgroup through the Marcus rate equation. These calculations have been performed for the different secondary structures of the glycine model peptide such as linear, alpha-helix, 3(10)-helix, and antiparallel beta-sheet by varying the dihedral angles omega, varphi, and psi along the Calpha-carbon of amino acid subgroup. Present theoretical results confirm that the charge transfer through the peptide bond is strongly affected by the conformations of the oligopeptide.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43724545,"openaccessinfo":{"externalids":{"MAG":"2093869651","ACL":null,"DOI":"10.1021\/JP063069N","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"As the prevalence of AIDS continues to grow, and current therapeutic agents begin to lose efficacy, the need for alternative treatments to combat HIV has become significantly greater. Targeting the highly conserved dimerization interface of HIV protease (PR) with interfacial peptides has been shown to reduce the activity of the enzyme due to generation of inactive monomers. The potency of these peptide-based inhibitors has been dramatically increased by cross-linking the interfacial sequences derived from HIV PR. This review focuses on a variety of strategies to develop potent, low-molecular-weight dimerization inhibitors of HIV PR.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29280804,"openaccessinfo":{"externalids":{"MAG":"2139017397","ACL":null,"DOI":"10.1002\/BIP.10232","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present investigation was designed to systematically examine the insanity defense typology proposed by Brown (2018) using a large sample of cases wherein there was support for the insanity defense. A total of 187 court-ordered cases in which an insanity defense was supported\u00a0were categorized based on the typology. The sample comprised of mostly single, middle-aged males who had been charged with a felony and diagnosed with a psychotic disorder. About half the sample was ultimately adjudicated not guilty by reason of insanity by the court. About two-thirds of the cases were categorized into one of the seven insanity defense subtypes using a coding scheme developed by the author of the typology. Inter-rater agreement occurred 82% of the time. The most frequent subtype was Paranoid Self-Defense, followed by \"But It's Mine\" and Paranoid Protection of Others. There were few differences among these subtypes based on demographic, clinical, offense, and outcome variables, except for presence of a primary psychotic disorder and offense type. Implications and ideas for future research are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235633795,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/bsl.2532","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a general optimization model gleaned ideas from plant root growth behaviors in the soil. The purpose of the study is to investigate a novel biologically inspired methodology for complex system modelling and computation, particularly for constrained multi-objective optimization. A novel method called 'multi-objective root growth algorithm' (MORGA) for constrained multi-objective optimization is proposed based on the root growth model. A self-adaptive strategy is adopted to tie this model closer to plant root growth behaviors in nature, as well as improve the robustness of MORGA. Simulation experiments of MORGA on a set of benchmark test functions are compared with other nature inspired techniques for multi-objective optimization which includes nondominated sorting genetic algorithm II (NSGA II) and multi-objective particle swarm optimization (MOPSO). The numerical results demonstrate MORGA approach is a powerful search and optimization technique for constrained multi-objective optimization. c 2013 IEEE.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":114688908,"openaccessinfo":{"externalids":{"MAG":"2416149886","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nCirculating transthyretin (TTR) is derived from the liver, and orthotopic liver transplantation (OLT) is widely performed for variant TTR-associated familial amyloid polyneuropathy (FAP). The effect of OLT on FAP-related cardiac amyloid is of particular interest because wild-type TTR can itself be deposited as senile cardiac amyloid.\n\n\nMETHODS\nSerial echocardiography was performed in 20 FAP patients, 14 of whom underwent OLT, and 10 other liver transplant patients. Follow-up included serum amyloid P component scintigraphy and measurement of plasma TTR before and after OLT.\n\n\nRESULTS\nCardiac amyloidosis progressed rapidly in three FAP patients (TTR Pro52 and Thr84 mutations) after OLT, even though the deposits elsewhere had stabilized or regressed. Results of echocardiography improved in three transplant patients with TTR Met30 and remained normal in seven other patients. Plasma TTR levels were altered substantially after OLT, but they did not reflect the cardiac findings.\n\n\nCONCLUSIONS\nAlthough amyloid deposition in FAP is generally inhibited after OLT, cardiac amyloidosis can be exacerbated, probably due to enhanced deposition of wild-type TTR on a template of amyloid derived from variant TTR. The phenomenon may be mutation-dependent. These findings suggest that amyloid formation de novo and its subsequent accumulation can be promoted by different factors, which may be organ-specific.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":21532023,"openaccessinfo":{"externalids":{"MAG":"1994398638","ACL":null,"DOI":"10.1097\/00007890-199807270-00016","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1097\/00007890-199807270-00016","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The culturological twist in modern science and practical activities implies the clarification of the essence of culture. Turning to the history of the philosophical thought, it is possible to trace the transformation of the understanding of culture, the origins of the current discontinuity between the rational cognition and the life-purpose positions, which are discovered in the renaissance anthropocentrism and metaphysics of the practical reason of the Modern period. The article addresses the perspective of the Kantian interpretation of culture, which examines the reason with regard to its origin and highest maxims.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235235978,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Communication engineers are now giving increased attention to detection systems which are able to adjust their own structure so as to be optimum for the particular detection problem of the moment. This paper describes a system which is capable of adapting and optimizing its response to the class of pulse signals whose individual pulses are less than T seconds in duration. The analysis and synthesis of the adaptive system is facilitated by the use of an orthogonal function decomposition of the received signal. The use of the orthogonal decomposition permits synthesis of optimum linear filters by various circuit techniques, several of which have been reported elsewhere. The structure of the system utilizing such a decomposition is described in detail. Since the operation of the adaptive filter is based upon signal detection and estimation in noise backgrounds, considerable attention is devoted to the relationship between optimum signal detection and estimation. The methods of statistical decision theory are used. A program to test the validity of the approximations and assess the over-all system performance was carried out by simulation of the system on both analog and digital computers. The results of these experimental runs are described.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":27107717,"openaccessinfo":{"externalids":{"MAG":"2099870790","ACL":null,"DOI":"10.1109\/TIT.1961.1057629","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective To propose a technique for SUV normalization on 18F-fluoride PET\/CT (18F-NaF) studies based on skeletal volume and to compare the SUVs normalized by this technique with the ones normalized by body weight. Methods SUVs were obtained in volumes of interest (VOIs) in proximal diaphyseal regions of the right humerus (HD) and right femur (FD) in 12 selected 18F-NaF studies. The 12 studies presented both regions considered normal by visual examination on PET and CT and were performed in patients presenting body weight below 50 kg (B50) or above 90 kg (A90) (6 patients in each group). The maximum SUVs were calculated in these 2 bone regions in both groups of patients using body weight (SUV BW) and skeletal volume (SUV SV) methodologies. The total skeletal volume for each patient was estimated based on whole skeletal VOIs automatically defined on the CT component of the PET\/CT study. The maximum SUVs calculated using the 2 methodologies were compared. Results The maximum SUVs BW were statistically higher in the group A90 in both regions, with a P < 0.001 and P < 0.008 for FD and HD, respectively. The maximum SUVs SV in the 2 regions were not statistically different between the groups B50 and A90, P values of 0.27 and 0.87 for FD and HD, respectively. Conclusions The SUVs normalized by skeletal volume present similar results in groups of patients with extremes of body weight. Therefore, this methodology could be more adequate than the one normalized by body weight to semiquantitatively analyze 18F-NaF studies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":12324005,"openaccessinfo":{"externalids":{"MAG":"2340905807","ACL":null,"DOI":"10.1097\/RLU.0000000000001221","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose This study aimed to investigate the analgesic effect and mechanism of electroacupuncture (EA) in nicotine withdrawal-induced hyperalgesia rats. Methods Behavioral testing was conducted twice a week for 7 weeks during nicotine administration using von Frey filaments. Electroacupuncture at the bilateral \"Zusanli\" and \"Taichong\" points was applied daily for 3 days during nicotine withdrawal. Western blot analysis and immunohistology were used to determine expression levels of pain-related factors in the spinal cord and midbrain periaqueductal gray (PAG). Results Behavioral tests showed that electroacupuncture had a significant analgesic effect on nicotine withdrawal-induced hyperalgesic rats. Western blot results demonstrated that, in hyperalgesic rats, the expressions of nicotinic acetylcholine receptors (subunits: nAChR \u03b17, \u03b14, or \u03b22) decreased in the spinal cord, nAChR \u03b17, and \u03b22 decreased in PAG. The proinflammatory factor cyclooxygenase 2 (COX2) and the activated microglia (ionized calcium-binding adaptor molecule 1, Iba1 positive cells) increased in the spinal cord and PAG compared to controls. After electroacupuncture treatment, nAChR \u03b17 and nAChR \u03b22 expressions increased significantly, and COX2 and Iba1 expressions decreased in the spinal cord. Compared with the nonelectroacupuncture nicotine withdrawal group, electroacupuncture stimulation increased the expression of nAChR \u03b17 and nAChR \u03b14 in the PAG of rats with electroacupuncture. Immunohistochemical results confirmed that electroacupuncture reversed nicotine withdrawal-induced changes in nAChR \u03b17 positive neurons and Iba1-positive microglia in the dorsal horn of the spinal cord. Conclusion Electroacupuncture treatment has an analgesic effect on nicotine withdrawal-induced pain in nicotine-dependent rats. The mechanism of analgesia of the electroacupuncture treatment relates to the increased expression of nAChR \u03b17 and nAChR \u03b22 proteins in the spinal cord, nAChR \u03b17 in the PAG, and decreased expression of Iba1 and COX2 protein in the spinal cord.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251963013,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2022\/7975803","PubMedCentral":"9444398","ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7975803.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This article describes three Web-mediated experiential case strategies employed with preservice teachers to facilitate practice of functional behavioral assessment skills. A pre-posttest group experimental design was used to examine the effects of three case-based teaching tactics on students' knowledge and application of information to conduct functional assessments. The results suggested that the three teaching tactics were equally effective in facilitating the application of functional behavioral assessment skills. However, there were some differences in the students' perceptions about the relevance and meaningfulness of their experiences as a means to teach functional assessment skills. Technology issues and other variables that could have influenced the results are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":146385344,"openaccessinfo":{"externalids":{"MAG":"2163438505","ACL":null,"DOI":"10.1177\/088840640302600102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Fly-ash (FA) \/wood-flour (WF) geopolymer composites (FWGCs) were prepared to investigate the influence of WF on the properties of FA-based geopolymer composites at different curing times. The crystallization, surface morphology, geopolymerization, interface analysis, and mechanical properties were characterized. The results indicated that the curing time exerted positive effects on the mechanical strength of the FWGCs. Noticeably distinct microstructures and mechanical properties were observed with different WF contents. The FWGCs with low WF loading (1 wt% and 5 wt%) presented almost unchanged or even improved mechanical properties compared to the pure FA-based geopolymer due to the existence of bonds between the WF and geopolymer matrix in the interface. However, the addition of WF to a higher content (10 wt%, 15 wt%, and 20 wt%) posted a negative influence on mechanical properties with insufficient polymerization of geopolymer and degradation of WF detected by morphology and elemental microanalysis. This study will facilitate a better understanding of the interaction between geopolymers and wooden materials, and serve as a basis for further research and applications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54577330,"openaccessinfo":{"externalids":{"MAG":"2786724406","ACL":null,"DOI":"10.15376\/BIORES.13.2.2499-2514","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study was conducted to determine the effect of factors such as financial fundamentals Earning Per Share (EPS), Return On Assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR) of the company and real property estate listed in Indonesia Stock Exchange during the period 2008-2013. The sampling technique used purposive sampling with a sample of five companies. Variables include the Earning Per Share (EPS), return on assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR) as the independent variable and stock price as dependent variables. Data were analyzed using descriptive statistical analysis and multiple linear regression analysis. The results of this study indicate that the simultaneous regression test (Test F), shows that the Earning Per Share (EPS), return on assets (ROA), Net Profit Margin (NPM), Debt To Equity Ratio (DER), and Current Ratio (CR ) simultaneously\u00a0 influence the stock prices of five companies that were visited. While partial regression test (t test) showed that the variable EPS, ROA, NPM and CR partial effect, whereas the variable DER has no partial effect on stock prices.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149726925,"openaccessinfo":{"externalids":{"MAG":"2884857087","ACL":null,"DOI":"10.22219\/jmbumm.Vol5.No2.%p","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The monocyclic compounds (BRg)3+(D3h), (BRg)42+(D4h), (BRg)53+(D5h) and (BRg)64+(D6h) formed between boron and rare gases Rg (He-Rn) are theoretically predicted to be stable structures and have \u03c0-aromaticity with a delocalized nc-2e \u03c0-system. For heavier rare gases Ar-Rn, the B-Rg bond energy is quite high and ranges from 15 to 96 kcal mol-1, increasing with the ring size and the atomic number of rare gases; the B-Rg bond length is close to the sum of covalent radii of B and Rg atoms; NBO and AIM analyses show that the B-Rg bonds for Ar-Rn have a typical covalent character. The B-Rg bond is stabilized mainly by \u03c3-donation from the valence p orbital of Rg to the vacant valence orbital of the boron ring. We searched for a large number of isomers for the systems of Ar and found that the titled monocyclic compounds (BAr)3+(D3h), (BAr)42+(D4h) and (BAr)53+(D5h) should be global energy minima. For (BAr)64+ the global energy minimum is an octahedral caged structure, but the titled monocyclic compound is the secondary stable local energy minimum. The energy and thermodynamic stability of the ring BnRgn(n-2)+ cations indicate that these rare gas compounds may be viable species in experiments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38372395,"openaccessinfo":{"externalids":{"MAG":"2725929078","ACL":null,"DOI":"10.1039\/c7cp00316a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Genetically encoded fluorescent voltage indicators are ideally suited to reveal the millisecond-scale interactions among and between distinct, targeted cell populations. However, current indicator families lack the requisite sensitivity for in vivo multipopulation imaging. We describe high-performance green and red sensors, Ace-mNeon2 and VARNAM2, and their reverse response-polarity variants, pAce and pAceR. Our indicators enable 0.4-1 kHz voltage recordings from >50 neurons per field-of-view in awake mice and \u223c30-min continuous imaging in flies. Using dual-polarity multiplexed imaging, we uncovered behavioral state-dependent interactions between distinct neocortical subclasses, as well as contributions to hippocampal field potentials from non-overlapping projection neuronal ensembles. By combining three mutually compatible indicators, we demonstrate concurrent triple-population voltage imaging. Our approach will empower investigations of the dynamic interplay between neuronal subclasses at single-spike resolution. One Sentence Summary A new suite of voltage sensors enables simultaneous cellular-resolution activity imaging from multiple, targeted neuron-types in awake animals.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":239021274,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2021.10.13.463730","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2021\/10\/15\/2021.10.13.463730.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"On a worldwide level, the dimension of tourism has been sustained and amplified by globalisation. This has facilitated not just easier travel, but also the internationalisation of food from the national kitchens. One of the interesting segments of the immaterial regional cultural heritage is the local gastronomic arts. Each destination has its own cultural vision linked to the area, region, and country which generate corresponding gastronomic identities. The link between local cuisine and national identity is deeply rooted in all ethnicities because food has forever been central to the day to day rituals. A distinctive trait of many cultures is given by the type of food and drinks we associate with them. Currently, many of these are available outside the borders, globalisation being largely responsible to the spread of food and drinks beyond the traditional cultural borders: Mexican and Italian food are very popular in the USA, Indian food in Great Britain, Chinese in the whole world. That is why local gastronomy is considered as being a vital part of culture and community and this is the reason for which it must be kept and protected. The gastronomy is an attribute of the identity of a destination: countries are usually characterised by one or two culinary plates, considered to be emblematic for the nation just like the national flag.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":158545691,"openaccessinfo":{"externalids":{"MAG":"2807895828","ACL":null,"DOI":"10.2478\/PICBE-2018-0063","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ogres belasianos\u00bb unit represents alluvial silicielastie sediments deposited during late Aptian to Cenomanian times in the Lusitanian Basin, on the western margin of the Iberian plate. Two fining-upward successions have been identitied in the unit by studies of vertical changes of lithofacies associations in tbe northern part of the basin. The Iower fining-upward succession corresponds to deposits of coalescent wet alluvial fans, changing to a braidplain witli local sinuosity. The upper succcssion records the transition from high slope braidplains with increasing sinuosity to fluvial-dominated deltaic deposits. Considering the available biostratigraphic data, the allocyclic controls on vertical changes of lithofacies assoeiations is discussed. It was inferred that the climate or a basin margin uplift were not the main control on system charaeter clianges. Furthermore, evidence in the offshore suggests that sea-level changes probably had a major influence. We believe that the onset of seafloor spreading in the Galician western margin and Bay of Biscay during upper Aptian to middle Albian have caused sea-level variations in the Lusitanian Basin, related to the thermal and isostatic adjustments. A relationship was admitted between the custatie curves of Haq et aL (1988) and the North Atiantie (Iberia included) geodynamic evolution. In the unit studied, the lower fining-upward succession probably corresponds to the supercycle LZB-4 and the upper tining-upward succession to UZA-i and part of the UZA-2 of Haq etal. (1988). Cuadernos de Geologia Iberica, nY 18, 27-5 8. Editorial Complutense, Madrid, 1994 L)ints, J. L. e, aL 28","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":129519914,"openaccessinfo":{"externalids":{"MAG":"1573815964","ACL":null,"DOI":"10.5209\/REV_CGIB.1994.V18.2573","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The publication actualizes the experience of organizing out-of-school education in Ukraine in the Soviet period (1952\u20131991) and indicates the ways of its use in modern conditions. The author singles out progressive ideas of the experience in the organization of out-of-school education in Ukraine in the period under study, which deserve consideration in the context of their implementation in out-of-school education in modern conditions: development of regulatory framework (it is stressed that now we observe inconsistency between regulatory and legislative framework concerning budgetary financing of out-of-school educational institutions and payment of teachers, scientific staff, specialists of other qualifications working there); creation of an extensive infrastructure of out-of-school educational institutions (it is proposed to pay attention to the resumption of carpentry, turning, wickerwork for boys; cooking, embroidery, knitting, tailoring for girls when forming a network of out-of-school educational institutions); state financial support; establishing relations of out-of-school educational institutions with state, private and public organizations (it is noted that now every leader and teaching staff faces the problem of determining the mechanism of establishing partnership interaction of out-of-school educational institutions with public authorities, local governments, public organization ); forming leisure culture in students (it is emphasized that further development requires a network of various out-of-school institutions that create the necessary conditions for comprehensive harmonious development of \u00a0teenagers, develop new forms and methods of out-of-school activities in the field of leisure, as well as ways of involving teenagers in various leisure activities both at school and in out-of-school clubs and creative centers); regulation and improvement of the system of professional training, retraining and advanced training of specialists in the system of out-of-school education; physical infrastructure support of out-of-school educational institutions (it is noted that \u00a0physical infrastructure support should include all the necessary equipment, facilities and inventory for various forms of organization \u00a0of out-of-school education (group, club, section, etc.).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233899600,"openaccessinfo":{"externalids":{"MAG":"3144961012","ACL":null,"DOI":"10.36550\/2415-7988-2021-1-192-84-88","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.36550\/2415-7988-2021-1-192-84-88","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Rose petals exhibit superhydrophobicity with strong adhesion to pin water drops, known as the 'petal effect.' It is generally believed that the petal effect is attributed to dual-scale roughness, that is, the surface possesses both a nanostructure and a microstructure (Feng et al 2008 Langmuir 24 4114). In this study, we demonstrate that the dual-scale roughness is not a necessary condition for a surface of the petal effect. A surface of single-scale roughness, either at the nanoscale or the microscale alone, within a certain roughness region may also exhibit the petal effect. The surface roughness plays the essential role on the wetting behavior and governs the contact angle in the Wenzel or Cassie state, as well as the contact angle hysteresis. A water drop on the surface of the petal effect under the condition of the advancing and receding contact angle would fall into, respectively, the Cassie and Wenzel state, which leads to a contact angle hysteresis large enough to pin the water drop. On both single and dual textured hydrophobic surfaces, a sequence of wetting transitions: Wenzel state \u2192 petal state (sticky superhydrophobic state) \u2192 lotus state (slippery superhydrophobic state) is consistently observed by simply increasing the surface roughness.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9928926,"openaccessinfo":{"externalids":{"MAG":"2148591111","ACL":null,"DOI":"10.1088\/0957-4484\/25\/34\/345303","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to investigate whether preoperative opioid use had any effect on clinical outcomes and patient-reported outcome measures (PROMs) before and after primary, elective total hip arthroplasty (THA). The authors retrospectively reviewed 793 patients who underwent primary THA from November 2018 to March 2020 with available PROMs. Patients were stratified into two groups based on whether or not they were taking opioids preoperatively. Demographics, clinical data, and PROMs (Forgotten Joint Score-12 [FJS-12], Hip disability and Osteoarthritis Outcome Score for Joint Replacement [HOOS, JR], and Veterans RAND 12 [VR-12] Physical Component Score [PCS] and Mental Component Score [MCS]) were collected at various time periods. Demographic differences were assessed with chi-square and independent sample t tests. Clinical data and PROMs were compared using multilinear regressions. Seventy-five (10%) patients were preoperative opioid users and 718 (90%) were not. Preoperative opioid users had a longer stay (1.37 vs 1.07 days; P=.030), a longer surgical time (102.44 vs 90.20 minutes; P=.001), and higher all-cause postoperative emergency department visits (6.7% vs 2.1%; P=.033) compared with patients not taking opioids preoperatively. Preoperative HOOS, JR (46.63 vs 51.26; P=.009), VR-12 PCS (27.79 vs 31.53; P<.001), and VR-12 MCS (46.24 vs 49.33; P=.044) were significantly lower for preoperative opioid users, but 3-month and 1-year postoperative scores were not statistically different. At 3 months and 1 year, FJS-12 scores did not differ significantly. Mean improvement preoperatively to 1 year in HOOS, JR values exceeded the minimal clinically important difference, with preoperative opioid users experiencing a greater improvement (36.50 vs 33.11; P=.008). Preoperative opioid users had a longer stay, a longer surgical time, and higher all-cause emergency department visits compared with preoperatively opioid na\u00efve patients. Although preoperative opioid users reported significantly lower preoperative PROMs, they did not statistically differ postoperatively, which indicates a larger delta improvement and similar benefits following THA. [Orthopedics. 2021;44(2):77-84.].","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234810888,"openaccessinfo":{"externalids":{"MAG":"3154630657","ACL":null,"DOI":"10.3928\/01477447-20210217-03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract A new species endemic to Mitiaro, Cook Islands, Tetramolopium mitiaroense, is described and illustrated. The species is most closely related to Hawaiian species of Tetramolopium section Tetramolopium. Tetramolopium mitiaroense shares an upright dwarf shrub habit with T. remyi and T. capillare but differs in possessing semi-succulent, linear-oblanceolate leaves versus sclerophyllous, involute, linear leaves for the latter two taxa. Tetramolopium sylvae also has succulent leaves but differs from T. mitiaroense in having a prostrate, rosette habit and spatulate leaves. A key is provided for all eastern Pacific species of Tetramolopium. Published morphological, molecular, and geological data are reviewed to assess relationships amongst Tetramolopium taxa in the eastern Pacific and elucidate the biogeographic pattern of dispersal. The data support the hypothesis that Tetramolopium was first dispersed to the Hawaiian Archipelago from New Guinea with a secondary dispersal event from the Hawaiian Islands to the Cook Islands. Available evidence indicates that the Pacific Golden-Plover is the probable agent of dispersal from the Hawaiian Islands to the Cook Islands.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":85981742,"openaccessinfo":{"externalids":{"MAG":"2169293224","ACL":null,"DOI":"10.1600\/0363644054223693","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"[Background] A cancer stem cell (cancer initiating cell, CSC) is considered capable of self -replication, self-differentiation, drug resistance, and immune evasion. Recently, CSC has become increasingly important in the treatment of malignant tumors. Cancer stem cells express specific molecules termed CSC marker, including ATP-binding cassette, G2 subfamily (ABCG2), aldehyde dehydrogenase (ALDH) 1A1, CD44, and CD44 variant 9 (CD44v9), and their expression has been reported to be the potential prognostic values. However, the prognostic values of ABCG2, ALDH1A1, CD44, and CD44v9 expression in patients with oral cancer are less understood. [Purpose] The aims of present study were to evaluate the expression of ABCG2, ALDH1A1, CD44, and CD44v9 in oral squamous cell carcinoma (OSCC) and to elucidate the relationships among the CSC marker expression, clinical stages, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. [Materials and Methods] Tissue specimens were obtains from 99 patients with OSCC after surgery or biopsy. Immunohistochemistry was used to assess ABCG2, ALDH1A1, CD44, and CD44v9 protein using at least 10% staining-positive cells as the definition of positive staining. [Results] Immunohistochemical analysis of 99 cases of OSCC showed that CD44 and CD44v9 expression were strongly detected in all OSCC compared with normal epithelial cells. Twenty eight (28.2%) cases of 99 OSCC patients expressed ABCG2. There was no relationship between ABCG2 expression and clinical stages, histological differentiation, metastasis, or disease-free survival rate. There was significant association between ABCG2 expression and classification of invasion mode. Otherwise, thirty one (31.3%) cases of 99 OSCC patients expressed ALDH1A1. There was no relationship between ALDH1A1 expression and clinical stagesor metastasis. However, there was significant association between ALDH1 expression and histological differentiation, or classification of invasion mode or disease-free survivalrate. [Conclusions] These findings suggested that the expression of ALDH1A1 as CSC markers in OSCC may be good marker indicating survival in patients with OSCC. Citation Format: Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Youji Miyamoto. Expression of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3888. doi:10.1158\/1538-7445.AM2014-3888","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":82837120,"openaccessinfo":{"externalids":{"MAG":"1504864064","ACL":null,"DOI":"10.1158\/1538-7445.AM2014-3888","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This Sarnoff-developed technology combines conventional Low-Temperature Cofired Ceramic (LTCC) technology and a clad metal base to provide constrained sintering, ruggedness, improved thermal path, and complex cavities with metal ground. Constrained sintering leads to almost zero shrinkage in the x-y plane during the firing operation allowing the accurate placement of embedded components such as resistors, capacitors, transmission lines, etc. This paper describes the development of CAD models for the design and analysis of embedded LTCC-M components. Models were verified by fabricating and testing LTCC-M test coupons for resistors, capacitors, and transmission lines. Results were compared with both EM simulation and circuit modeling. These CAD models operate within the industry standard HP Communications Design Suite utilizing its existing library models; an efficient and cost effective approach. Models, test results, range of validity of these models, and design guidelines are presented.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":37619741,"openaccessinfo":{"externalids":{"MAG":"1846306194","ACL":null,"DOI":"10.1109\/MWSYM.1998.700608","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A lot of literature on credit risk scoring techniques exists, but less research is available regarding the mapping of credit scores to ratings and the calibration of ratings. This paper introduces an algorithm for mapping credit scores to credit ratings and estimating a probability of default (PD) per rating grade. The algorithm is based on step-wise partitioning of the cumulative accuracy profile, such that requirements like stable ratings and a monotonous PD scale, as stated by the European Banking Association's regulatory technical standards, are fulfilled. We test the algorithm by simulating different PD models and score distributions. These tests reveal that the algorithm maps credit scores to significantly different rating grades. Each rating cor- responds to a PD, which is a monotonous function of the rating grade. The tests also show that the total number of rating grades, which result from the mapping algorithm, strongly depends on the ability of the scoring model to discriminate between defaulting and non-defaulting counter-parties.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":159135119,"openaccessinfo":{"externalids":{"MAG":"2923979063","ACL":null,"DOI":"10.21314\/JCR.2018.240","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Technological change has always had a strong influence on the economy. In the case of the Information and Communications Technologies (ICT), their incessant penetration has transformed traditional working places, such as the office. Although many white collar activities have survived given the enduring reliance on qualified staff with abundant skills and experience, they now seem at risk due the progressive automation of clerical work. These trends are not exclusive of industrialized nations, though. Then, we pose the following question: to what extent is technological change affecting skilled jobs in developing nations too, and more specifically in Mexico? In attempting to answer this question, we examine the impact of ICTs on six skilled jobs in Mexico City: data entry keyers, photographers, computer systems analysts, messengers, stenographers and lathe operators. We found that traditional occupations have indeed disappeared, whereas specialized manufacturing jobs, such as lathe operators, seem to be still required by the market, although in a lesser extent. We conclude that jobs are no longer defined by traditional skills but by multitasks abilities, especially in ICTs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10253594,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A 46-year-old woman presented with a history of decreased vision. On examination, best-corrected visual acuity was 20\/30 in both eyes. Fundus evaluation of the right eye revealed subretinal fibrosis of the macula involving the fovea. The fundus of the left eye was normal. Fluorescein angiography confirmed the diagnosis. At 10 months of follow-up, the patient was asymptomatic and the visual acuity was stable at 20\/25 in both eyes. Liquid crystal display microperimetry showed comparable retinal sensitivity in both eyes (P> .05). However, the right eye revealed unstable fixation compared to the left eye. Idiopathic subretinal fibrosis should be considered in the differential diagnosis of patients with subretinal fibrosis. Liquid crystal display microperimetry is a useful tool in evaluating these patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24264676,"openaccessinfo":{"externalids":{"MAG":"2252862034","ACL":null,"DOI":"10.3928\/1542-8877-20040701-09","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Tourism, like mining or manufacturing can deplete the natural resources on which it survives, particularly if it is ill-planned and mismanaged. Paradoxically, tourism is a natural resource dependent industry and the natural and cultural environment of destination countries provides one of the major magnets for tourism (Mathieseon and Wall (1982). Yet, tourism can cause a lot of harm to the natural landscape. The purpose of this paper is to assess the impacts of tourism on natural resource use and management in Botswana. Not much bas been researched about the effects of tourism on natural resources in the country thus far, despite the fact that the industry is growing rapidly in Botswana.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129185831,"openaccessinfo":{"externalids":{"MAG":"1586987364","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The assignment of lines in vibrational spectra in strongly mixing systems is considered. Several low lying vibrational states of the ground electronic X\u223c2E state of the CH3O and CD3O radicals are assigned. Jahn-Teller, spin-orbit, and Fermi couplings mix the normal mode states. The mixing complicates the assignment of the infrared spectra using a zero-order normal mode representation. Alternative zero-order representations, which include specific Jahn-Teller couplings, are explored. These representations allow for definitive assignments. In many instances it is possible to plot the wavefunctions on which the assignments are based. The plots, which are shown in the adiabatic representation, allow one to visualize the effects of various higher order couplings. The plots also enable one to visualize the conical seam and its effect on the wavefunctions. The first and the second order Jahn-Teller couplings in the rocking motion dominate the spectral features in CH3O, while first order and modulated first order couplings dominate the spectral features in CD3O. The methods described here are general and can be applied to other Jahn-Teller systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8593783,"openaccessinfo":{"externalids":{"MAG":"2611261624","ACL":null,"DOI":"10.1063\/1.4981795","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Cardiac glycosides (CG) are of forensic importance because of their toxicity and the fact that very limited methods are available for identification of CG in biological samples. In this study, we have developed an identification and quantification method for digoxin, digitoxin, deslanoside, digoxigenin, and digitoxigenin by high-performance liquid chromatography tandem mass spectrometry (HPLC\/MS\/MS). CG formed abundant [M + NH4]+ ions and much less abundant [M + H]+ ions as observed with electrospray ionization (ESI) source and ammonium formate buffer. Under mild conditions for collision-induced dissociation (CID), each [M + NH4]+ ion fragmented to produce a dominant daughter ion, which was essential to the sensitive method of selected reaction monitoring (SRM) quantification of CG achieved in this study. SRM was compared with selected ion monitoring (SIM) regarding the effects of sample matrixes on the methodology. SRM produced lower detection limits with biological samples than SIM, while both methods produced equal detection limits with CG standards. On the basis of the HPLC\/MS\/MS results for CG, we have proposed some generalized points for conducting sensitive SRM measurements, in view of the property of analytes as well as instrumental conditions such as the type of HPLC\/MS interface and CID parameters. Analytes of which the molecular ion can produce one abundant daughter ion with high yield under CID conditions may be sensitively measured by SRM. ESI is the most soft ionization source developed so far and can afford formation of the fragile molecular ions that are necessary for sensitive SRM detection. Mild CID conditions such as low collision energy and low pressure of collision gas favor production of an abundant daughter ion that is essential to sensitive SRM detection. This knowledge may provide some guidelines for conducting sensitive SRM measurements of very low concentrations of drugs or toxicants in biological samples.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23392930,"openaccessinfo":{"externalids":{"MAG":"2066546292","ACL":null,"DOI":"10.1021\/AC990268C","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The fruits of Barringtonia racemosa are prescribed in the ayurvedic literature for the treatment of pain, inflammation and rheumatic conditions. In present investigation, activity guided isolation of bartogenic acid (BA) and its evaluation in the Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported. Among the various extracts and fractions investigated preliminarily for carrageenan-induced acute inflammation in rats, the ethyl acetate fraction displayed potent anti-inflammatory activity. Large-scale isolation and characterization using chromatography and spectral study confirmed that the constituent responsible for the observed pharmacological effects was BA. Subsequently the BA was evaluated for effectiveness against CFA-induced arthritis in rats. The results indicate that at doses of 2, 5, and 10\u2009mg\u2009kg\u22121\u2009day\u22121, p.o., BA protects rats against the primary and secondary arthritic lesions, body weight changes and haematological perturbations induced by CFA. The serum markers of inflammation and arthritis, such as C-reactive protein and rheumatoid factor, were also reduced in the BA-treated arthritic rats. The overall severity of arthritis as determined by radiological analysis and pain scores indicated that BA exerts a potent protective effect against adjuvant-induced arthritis in rats. In conclusion, the present study validates the ethnomedicinal use of fruits of B. racemosa in the treatment of pain and inflammatory conditions. It further establishes the potent anti-arthritic effects of BA. However, additional clinical investigations are needed to prove the efficacy of BA in the treatment of various immuno-inflammatory disorders.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14132303,"openaccessinfo":{"externalids":{"MAG":"2052860737","ACL":null,"DOI":"10.1093\/ecam\/nep148","PubMedCentral":"3137566","ArXiv":null},"license":null,"url":"https:\/\/downloads.hindawi.com\/journals\/ecam\/2011\/785245.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to formulate instant baby porridge as a source of protein weaning food based on red beans flour and canna starch composite. The design of this study was a complete randomized design with one factor which was the ratio of red beans flour and canna starch in composite composition as instant porridge ingredient (2:1, 3:1, and 4:1). Based on organoleptic test, F2 which used red bean flour and starch canna ratio by 3:1 was the best formula. The optimal time to brew the instant porridge was 62 seconds with amount of water used was 3 ml\/g. The instant porridge bulk density was 0.61 g\/ml and water absorption was 4.67g\/g. This instant porridge contained 363 kcal\/100 g, 16.57% protein, 1.48% fat, 70.84% total carbohydrate, 197.70 mg calcium, 8.17 mg zinc, and 16.48 mg iron. Protein digestibility of this porridge was 79.83%. As per 27 g serving size of this instant porridge can fulfill 22.25% protein, 55.25% iron, 27.63% zinc so that it can be claimed as food source of protein and zinc, and high iron.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56084727,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The world is in uncharted waters for the 2020 respiratory virus season. For the first time in modern history, the Northern Hemisphere faces the prospect of the coronavirus disease 2019 (COVID-19) pandemic and a simultaneous epidemic of seasonal influenza. Each causes life-threatening illness and death, especially in older adults, people with chronic diseases, and other vulnerable populations. How can we prepare for this convergence?","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":219585351,"openaccessinfo":{"externalids":{"MAG":"3035273565","ACL":null,"DOI":"10.1126\/science.abd2220","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.abd2220?download=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract. According to the function, land space types are divided into key development areas, restricted development areas and forbidden development areas in Sichuan Province. This paper monitors and analyses the changes of land cover in different typical functional areas from 2010 to 2017, which based on ZY-3 high-score images data and combined with statistical yearbook and thematic data of Sichuan Province. The results show that: The land cover types of typical key development zones are mainly composed of cultivated land, forest land, garden land, and housing construction land, which accounts for the total area of land cover 87\u2009%. The land cover types of typical restricted development zone mainly consists of forest land and grassland, which occupy 97.71\u2009% of the total area of the surface coverage. The land cover types of the typical prohibition development zone mainly consist of forest land, grassland, desert and bared earth, which accounts for the total area of land cover 99.31\u2009%.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":134622901,"openaccessinfo":{"externalids":{"MAG":"2799978591","ACL":null,"DOI":"10.5194\/ISPRS-ARCHIVES-XLII-3-815-2018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The environment and personnel are both exposed to powdered pharmaceuticals inside pharmacies. This makes developing new methods for rapidly determining such contaminants an important objective. In this study, we developed a liquid-chromatography tandem-mass-spectrometry (LC\u2013MS\/MS) method for the simultaneous qualitative and quantitative determination of powdered medicinal drugs, such as famotidine, risperidone, lansoprazole, olanzapine, haloperidol, clarithromycin, promethazine, levomepromazine, and chlorpromazine. The method involves the use of acetaminophen as the internal standard, an LC\u2013MS\/MS method with a core\u2013shell column, and a 10 mM ammonium formate\/acetonitrile gradient mobile phase. The analytes were separated within 14 min, and MS with an electrospray ionization source in positive-ion mode was used. The limits of detection for the 9 drugs were .1-8.4 ng\/mL. Linear calibration curves in the 10-50 000 ng\/mL range were constructed, and inter-day accuracies of 92.6-113.8% were determined for the 9 drugs. The coefficients of variation were less than 14.6%. These data suggest that the proposed method is applicable for the routine assaying of powdered-medicine contamination in pharmacies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":244799759,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/00469580211059281","PubMedCentral":"8649453","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.1177\/00469580211059281","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"AN EARLIER PAPER1 introduced a method for handling multiple nonlinearities through describing functions, and developed such describing functions for single-stage electrohydraulic control valves. This work is extended in this paper to 2-stage valves of the type shown in Fig. 1. Most of the essential nonlinearities are included in the describing function which is brought to a form similar to that for the single-stage valve.1 Precalculated charts are utilized which help to make reasonable the amount of labor of computing the describing function for a specific valve. An example in the paper illustrates the use of the describing function, and very good agreement with analog computer studies is demonstrated.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":51633456,"openaccessinfo":{"externalids":{"MAG":"2010638429","ACL":null,"DOI":"10.1109\/TAI.1958.6367381","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using N-body simulations, we study the properties of a bar induced in a discy dwarf galaxy as a result of tidal interaction with the Milky Way. The bar forms at the first pericentre passage and survives until the end of the evolution at 10 Gyr. Fourier decomposition of the bar reveals that only even modes are significant and preserve a hierarchy so that the bar mode is always the strongest. They show a characteristic profile with a maximum, similar to simulated bars forming in isolated galaxies and observed bars in real galaxies. We adopt the maximum of the bar mode as a measure of the bar strength and we estimate the bar length by comparing the density profiles along the bar and perpendicular to it. The bar strength and the bar length decrease with time, mainly at pericentres, as a result of tidal torques acting at those times and not to secular evolution. The pattern speed of the bar varies significantly on a time-scale of 1 Gyr and is controlled by the orientation of the tidal torque from the Milky Way. The bar is never tidally locked, but we discover a hint of a 5\/2 orbital resonance between the third and fourth pericentre passage. The speed of the bar decreases in the long run so that the bar changes from initially rather fast to slow in the later stages. The boxy\/peanut shape is present for some time and its occurrence is preceded by a short period of buckling instability.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":119180664,"openaccessinfo":{"externalids":{"MAG":"1984481238","ACL":null,"DOI":"10.1093\/mnras\/stu1846","PubMedCentral":null,"ArXiv":"1404.1211"},"license":null,"url":"https:\/\/academic.oup.com\/mnras\/article-pdf\/445\/2\/1339\/18197947\/stu1846.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Abstract : Fiber Reinforced Composite (FRC) materials offer the possibility of reduced mass and increased performance over metals. Used in internal combustion engines, this may enable increased power and mechanical efficiency. Previous work has both shown structural and thermal limitations. A net-shape resin transfer molded intake valve has been developed, using a single-piece carbon fiber preform and the high temperature polymer PETI-RFI. Performance has been validated through testing. High engine load conditions resulted in thermal failure of FRC valves. Thermal modeling was conducted to simulate the effect of fiber orientation and coating combinations on transient thermal performance of FRCs. One dimensional modeling has predicted FRC valve surface temperatures to be 12O deg. C higher than that of a steel valve. Simply re-orienting conductive fiber along the heat path may reduce the temperature rise to below that of steel. Two dimensional analysis has resulted in a novel method of evaluating thermal performance. Using the unitless ratio of thermal resistance at the coating surface and at the interface boundary, designated Bb, an accurate prediction of the interface temperature can be obtained. Relative temperature gradients in both coating and core materials can also be estimated. Using this methodology a fiber and coating structure is proposed that reduces FRC core temperature by 80%. It has been shown that careful selection of fiber orientation and coating materials can enable a polymer matrix composite material to withstand the structural and thermal environment of an IC engine combustion chamber.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":135504925,"openaccessinfo":{"externalids":{"MAG":"1941782845","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Spatial patterns of land \ncover changes in the Omo-Shasha-Oluwa Forest Reserves were conducted on Landsat \nTM and ETM+ imageries of 1986 and 2002 using remote sensing and GIS techniques. \nExtent of tree plantation (Gmelina arborea) grew from about 145 sq. km \nin 1986 to about 322 sq. km in 2002 (122% increase). The natural forest \ndeclined from about 2569 sq. km in 1986 to about 2253 sq. km by 2002, while the \nnon-forest areas increased by some 5% from 341 km2\u00a0in 1986 to about 490 km2\u00a0by 2002. Land cover pattern and its \nchanges in the study area are linked to both natural and anthropogenic \nprocesses such as illegal logging, demand for soft wood for industries and \nexpansion of settlements. The conversion of natural forest into monoculture \nplantations should be discouraged because they do not give room for \nbiodiversity. Specific forestry and environmental laws and regulations that \nsignificantly address landscape changes in reserved and protected areas should \nbe enforced to reduce activities that negatively affect the forest reserves. \nThere is also the need to develop a wider and more integrated GIS system of the \nforest and other land resources in the country to assist different kinds of \nplanning and management activities.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":56270787,"openaccessinfo":{"externalids":{"MAG":"2033177240","ACL":null,"DOI":"10.4236\/JGIS.2014.64033","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Carbonate reservoir rocks of the Najmah formation in Kuwait, with low porosity and low permeability, have been characterized using integrated digital and physical rock analyses methods. High-resolution imaging and analyses determined the microstructural characters of mineral matrix, organic matter (OM) distribution, organic and inorganic pore types, size distribution, and permeability variation within this kerogen-rich Late Jurassic stratigraphic unit.\n Considerable heterogeneity of porosity and permeability was observed in the 100-ft studied interval of the Najmah Formation. Two-dimensional scanning electron microscopy (2D-SEM) imaging and three-dimensional focused ion beam SEM (3D-FIB-SEM) imaging highlighted the different types of porosities present within the formation rock. At each depth, several 2D-SEM images were used for characterization and selection of representative locations for extracting 3D FIB-SEM volumes. The 3D volumes were digitally analyzed and volumetric percentages of OM and total porosity were determined. The porosity was further analyzed and quantified as connected, nonconnected, and associated with organic matter. Connected porosity was used to compute absolute permeability in the horizontal and vertical directions in the area of interest.\n Porosity associated with OM is an indicator of OM maturity and flow potential. It has been categorized as pendular type, spongy large grain, spongy small grain, fracture porosity within the OM, grain boundary fractures and intergranular porosity covering the entire OM. Permeability is not only influenced by porosity within OM or even apparent transformation ratio (ATR), it is also dependent on pore connectivity, pore sizes, and heterogeneity (e.g., high-permeability streaks). For high porosity samples, almost all pores are connected and contributing to permeability. For low porosity samples with high permeability, the flow is mainly through microfractures. It is possible that intergranular clay pores in highly thermally mature rocks were originally filled with OM and that, during progressive thermal maturation, transformation of OM to hydrocarbon(s) removed much of the pore filling OM.\n It has also been observed that, although the total organic carbon (TOC) content of the rocks is significant (up to 18 wt%), and good maturity index (VR0>1), only few examined samples show good connected porosity within the OM. It is essential to evaluate the porosity within the OM thorough high-resolution measurements for pinpointing the prospective layers for future stimulated horizontal wells in this organic-rich source unit. These intervals can be considered as the potential sweet spots after integration with detailed petrophysics and geomechanical parameters for optimized well planning and completion design.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210625374,"openaccessinfo":{"externalids":{"MAG":"2982997906","ACL":null,"DOI":"10.2118\/197507-ms","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A method of moments formulation for the scattering and radiation analysis of single or multiple bodies made of conducting and lossy dielectric materials or conducting and lossy magnetic materials is presented. Based on this formulation, a simulation code for the analysis of rotationally symmetric geometries has been developed. The numerical solution is obtained using an integral-equation formulation, for which several different forms can be selected. Numerical results for the scattering from conducting objects partially coated with a lossy dielectric material and conducting objects partially coated with a lossy magnetic material are presented. >","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":122412662,"openaccessinfo":{"externalids":{"MAG":"2113412975","ACL":null,"DOI":"10.1109\/20.105048","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Ultrasonic Langevin transducers are used in several power ultrasound applications. However, nonlinear effects can influence their performance, especially in a high vibration amplitude level. These nonlinear effects produce variations in the resonant frequency, harmonics of the excitation frequency, loss of symmetry in the frequency response around the resonances and a \"frequency domain hysteresis\", also known as jumping and dropping phenomena. This work presents a simplified model to take into account the most relevant nonlinear effects using only two parameters, one to reproduce the changes in the resonance frequency and the other to introduce the dependence with the history in the frequency sweep. The piezoelectric constitutive equations are extended using a linear dependence of the elastic constant with the amplitude of the mechanical displacement. In order to introduce the frequency hysteresis, the elastic constant is computed using a combination of the current value of the amplitude with the previous state amplitude. The results were tested using different Langevin type transducers. In this work a 26 kHz transducer, originally developed by Mectron Medical Technology (Italy) for bone surgery, is evaluated in a wide range of input voltages and sweeping the frequency up and down in every case.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":112724262,"openaccessinfo":{"externalids":{"MAG":"2320312033","ACL":null,"DOI":"10.3850\/978-981-07-5938-4_P0112","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although targeted anticancer agents often result in dramatic responses, tumors invariably become resistant to these agents. A detailed understanding of the mechanisms by which tumors acquire resistance to such inhibitors should speed the development of more durable treatment strategies. The promise of RAF inhibition in metastatic melanoma is exemplary in this regard. Mutations in the BRAF oncogene have been detected in more than 50% of metastatic melanomas, and inhibition of mutant BRAF has shown high response rates in early clinical trials of patients with melanoma. However, resistance to RAF inhibition invariably develops. Mechanisms of de novo and acquired resistance to RAF inhibition remain poorly understood. Moreover, the clinical application of genomic approaches that might be capable of diagnosing salient resistance mechanisms remains underdeveloped. Here, we describe an approach to characterize genetic mechanisms of resistance through systematic tumor mutation profiling. We performed massively parallel sequencing of 138 cancer genes in a tumor specimen from a melanoma patient who developed resistance to PLX4032 after a dramatic initial response. The resulting profile identified a novel mutation in the downstream kinase MEK1 that was absent in the corresponding pre-treatment tumor. This MEK1 mutation was shown to increase kinase activity and confer robust resistance to both RAF and MEK inhibition in vitro. Our results provide an instructive framework both for assessing mechanisms of acquired resistance to kinase inhibition and deploying new technologies for elaboration of resistance mechanisms in a manner that may accelerate personalized cancer medicine. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3933. doi:10.1158\/1538-7445.AM2011-3933","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70972308,"openaccessinfo":{"externalids":{"MAG":"1964896102","ACL":null,"DOI":"10.1158\/1538-7445.AM2011-3933","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Real-time and accurate stress calculation in walls of vasculature is desired to provide catheter insertion robots of feedback control without changing the catheter stiffness and lumen. This feedback source has also applications in endovascular surgery simulation for human skills and medical tools evaluation. For that purpose we consider photoelastic effect, as birefringence produced by light retardation relates with the stress inside the photoelastic materials. In this research a polariscope was designed for urethane elastomer vasculature models, the photoelastic coefficient of urethane elastomer was measured, and the camera system was calibrated to quantify and reduce error of the measurement system. An average error of 3.6% was found for the pressure range of 70\u2013189 mmHg inside the model of urethane elastomer, this enables to calculate accurately stress in vasculature models during Human Blood Pressure Simulation (HBPS). That way we will be able to compare in a closed loop stress produced by HBPS and by the catheter motion when manipulated by a robot.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":47491072,"openaccessinfo":{"externalids":{"MAG":"2039198702","ACL":null,"DOI":"10.1109\/TMECH.2010.2041786","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Play is an effective approach to engaging children in learning as an alternative to traditional lecturing. The Learning through Play (LtP) approach involves various modes of learning participation, including multi-sensory participation, interpersonal interaction, and hands-on operation, which can effectively motivate children to learn. This study implemented an LtP pilot survey in several first-tier cities of China, which included questionnaires and interviews. The results present the basic ecology of LtP in China, LtP effects on children's multimodal learning. We found that LtP has gained great popularity, both conceptually and practically, in China. LtP stakeholders recognize the behavioral, cognitive, and affective effectiveness of LtP for children's learning. The factors influencing the effectiveness of LtP include its structural weaknesses, the subjects involved, the environment, and culture. This study provides a reference for promoting the theory and practice of children's multimodal learning with a playful approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":258971545,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fpsyg.2023.1103311","PubMedCentral":"10263124","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2023.1103311\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In this work, we demonstrate and evaluate a new design of micro-structured core erbium-doped few-mode fiber to be used as optical amplifier in the context of mode-division multiplexing. This concept is proposed so as to better control the distribution of the Er3+ ions in the core area, thus permitting to adjust the overall differential modal gains between the different signal modes. The design presented here consists of 19 erbium-doped inclusions embedded in a pedestal geometry guiding 10 modes in the C-band. It has been optimized numerically so as to reach the equalized amplification of all the signal modes. The fiber has been realized and combined with custom-made dual-wavelength mode multiplexers based on multi-plane light conversion to shape the signal and pump beams. Amplification properties have finally been evaluated experimentally.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253442220,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1364\/oe.473902","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1364\/oe.473902","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In her recent article, \"The One Necessary Condition for a Business Ethics Course: The Teacher Must be a Philosopher,\" Ellen Klein argues that philosophers are best qualified to teach business ethics by virtue of their expertise in ethical theory. Klein likens her claim to that of Plato's \"philosopher-king,\" who claimed that the philosophet is best suited to be \"king,\" because he possesses a theoretical understanding of justice. In response to Klein, I point to Aristotle's ob jection to Plato, which shows that theoretical knowledge of ethics is not sufficient for making a person ethical, because ethics requires both theoretical and practical knowledge. Ultimately, I argue that in order to have a successful business ethics class, one must address both the issues unique to ethical theory, and the particular structures and contexts that are unique to making an ethical decision within the business environment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":148173528,"openaccessinfo":{"externalids":{"MAG":"2406308310","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The poultry industry provides a good employment opportunity for both males and females along with agricultural activities. The poultry industries were involved with live stock, which is monitored around the clock and the poultry entrepreneurs are very much concentrated in utilizing the farm optimally enriching maximum output through selling the eggs and other allied products like feathers, gunny bags and poultry litters etc. The poultry entrepreneurs have gained a good profit and a particular portion of the profit was correctly paid towards income tax. Hence, the Indian economy gain the momentum through poultry industries. But after the introduction of globalization, many foreign countries launched their business in various areas namely production, marketing, transporting, banking, insurance, IT and IT enabled industries. In order to show much glamour for the industries and offices they had consumed heavy electricity power and make their premises fully air-conditioned for round the clock. The state government has not planned well to distribute the electricity power equally for already existing industries, the newly arrived foreign originated industries and service oriented organization. This affected drastically and the frequent power cuts were vested with the shoulders of poultry farms and feed mills and poultry egg packaging industries. Due to this frequent power cut, the agriculturalist in the dry land finds difficult to produce first quality maize, which is the core raw material for poultry feed. Hence, after liberalization many of the small poultry entrepreneurs were found very difficult to produce the quality eggs in their poultry farms and these eggs finds difficult to compete in the global market.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153835486,"openaccessinfo":{"externalids":{"MAG":"1572173800","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During a brand crisis, this research investigates the impact of brand super-recovery efforts and online brand community engagement (OBCE) on repurchase intention as mediated by consumer forgiveness. The data for this quantitative study was gathered from members of the Tokopedia community in Central Java. Partial Least Squares Structural Equation Modeling is the analytical technique used (PLS-SEM). The results indicate that brand super-recovery efforts and online brand community engagement (OBCE) influence repurchase intention directly or indirectly via the mediating variable of consumer forgiveness. The results indicate that when a brand crisis occurs, the presence of a brand super-recovery effort, online brand community engagement (OBCE), and consumer forgiveness can reduce the negative impact of a brand crisis and encourage customers to repurchase. This research results have significant implications for theory and practice.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250100906,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.30574\/wjarr.2022.14.3.0605","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/wjarr.com\/sites\/default\/files\/WJARR-2022-0605.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"A study was initiated to develop a more efficient method of producing high-titered L cell interferon. The induction of interferon by viral infectious RNA could be augmented by pretreating the cell cultures with insulin and infecting in the presence of Amphotericin B methyl ester (AmBME). L cells were treated for 24 hr with different concentrations of insulin and then challenged with MM virus RNA suspended in a balanced salt solution with and without AmBME. The fluids were collected 48 hr after infection and assayed for interferon activity. Interferon production was markedly increased in insulin-treated cultures and that the increase was dose-dependent.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10271497,"openaccessinfo":{"externalids":{"MAG":"1987473127","ACL":null,"DOI":"10.1089\/JIR.1981.1.581","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Grazing effects by introduced mammals on tree seedlings in the arid zone have caused concern for the long-term future of some tree species. This was investigated by measuring stem girths of Casuarina cristata Miq., Heterodendrum oleifoliurn Desf. and Myoporum platycarpum R.Br. in arid-zone wood- lands. Episodic seedling regeneration of Myoporum is inferred following series of wet years in the 1950s and 1970s. Although young Myoporum plants appear unpalatable to stock, regeneration may be sup- pressed by rabbit-grazing in some areas. Almost no Heterodendrurn seedlings were found but suckering was common after burning and clearing. This species is highly palatable to grazing mammals and suckers may grow to safety above the browse line only where stock are absent. Evidence for recent Casuarina seedling regeneration was limited to one cohort, on a site that had been flooded. While suckers can be found locally where surface roots become exposed, suckering appears insufficient to perpetuate many Casuarina stands. Mammal-grazing seems important in strongly limiting regeneration. While Casuarina and Heterodendrum stand densities decline due to natural senescence and occasional fire, the only species regenerating into gaps is Myoporum. There is concern for the future of Casuarina and Heterodendrum, given their widespread failure to regenerate despite the wettest 3 years ever recorded, in 1973-75. On pastoral land, at least 10 years without stock-grazing might be needed for successful regeneration of Heterodendrurn. In reserves, some nature conservation programs for woodlands might require virtual eradication of all exotic mammalian herbivores, including goats.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":85290255,"openaccessinfo":{"externalids":{"MAG":"2084417618","ACL":null,"DOI":"10.1071\/BT9850715","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rehabilitation of atrophic maxilla with dental implants is still a challenge in clinical practice especially in cases of alveolar bone resorption due to peri-implantitis and pneumatization of the maxillary sinuses. Several surgical approaches have been employed to reconstruct the lost tissues allowing the proper tridimensional position of the implants. In this context, the aim of this case report is to describe a surgical and prosthetic approach to fully rehabilitate the atrophic maxilla with dental implants. The patient presented with unsatisfactory functional and esthetical implant-supported prosthesis with some of the implants already lost by peri-implantitis. The remaining three implants were also affected by peri-implantitis. Reversal prosthetic planning was performed, and a provisional prosthesis was fabricated and anchored in two short implants. Sinus floor augmentation procedure and onlay bone graft were then accomplished. After a healing period of 8 months, digital-guided surgery approach was performed to place the implants. Finally, a definitive prosthesis was installed. One-year follow-up has revealed stabilization of the bone tissue level, successful osseointegration, and a pleasant esthetic and functional result. A proper diagnosis and careful planning play an important role to enhance precision and to achieve patient esthetic and functional outcomes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233232275,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2021\/6637500","PubMedCentral":"8026321","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1155\/2021\/6637500","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a laboratory investigation aimed at establishing a protocol for the production of homogeneous asphalt mixtures test specimens, incorporating reclaimed asphalt by using a gyratory compactor with coring and trimming works. Stone mastic asphalt specimens were compacted at the previously identified target densities with the final aim of obtaining specimens with a fixed and homogeneous air void distribution. A microstructural study was conducted to characterize the homogeneity in the air void distribution using X-ray computed tomography (CT) combined with image analysis techniques. The study concluded that the gyratory compactor is suitable for producing homogeneous test specimens for the specified mixtures and a set of detailed procedures has been proposed for the production of the compacted specimens and to perform the microstructural study.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":136693355,"openaccessinfo":{"externalids":{"MAG":"2044250276","ACL":null,"DOI":"10.1061\/(ASCE)MT.1943-5533.0001012","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Twins Pat and Isabel are disappointed when they have to miss the first week of the new term. But they soon settle down again, and the summer term brings all sorts of excitement and several new girls, some of whom are less popular than others.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129329905,"openaccessinfo":{"externalids":{"MAG":"1601735562","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present invention relates to a method and a kit for diagnosing and\/or predicting the occurrence of cancer or the risk of contracting a cancer by measuring the concentration of a cancer screening antigen (CSA) in blood, which changes before the occurrence of the cancer in a patient. The method of diagnosing or predicting the occurrence of cancer or the risk of contracting a cancer comprising the steps of: determining a concentration of galectin-3 in a blood sample by reacting the blood sample with a monoclonal antibody of the galectin-3; comparing the determined concentration of the galectin-3 with concentration of the galectin-3 in a blood sample of a normal human; and predicting the risk of contracting a cancer if the determined concentration is greater than the concentration of the galectin-3 in blood of the normal human.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":145920125,"openaccessinfo":{"externalids":{"MAG":"2938664531","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Crystal and magnetic structures of BiMnO(3+delta) (delta = 0.03, 0.08, and 0.14) have been determined by the Rietveld method from neutron diffraction data at 8-10 and 290 K. BiMnO(3.03) (= Bi(0.99)Mn(0.99)O(3)) crystallizes in a monoclinic system (the refinement was performed in space group C2\/c; Z = 8; a = 9.5313(3) A, b = 5.57791(17) A, c = 9.7375(4) A, beta = 108.951(2) degrees at 290 K). BiMnO(3.08) (= Bi(0.974)Mn(0.974)O(3)) crystallizes in space group P2(1)\/c (Z = 8; a = 9.5565(4) A, b = 5.51823(16) A, c = 9.7051(4) A, beta = 109.442(3) degrees at 290 K). It was found that Mn vacancies are localized mainly in one Mn site (among three sites) in Bi(0.974)Mn(0.974)O(3). Vacancy-ordering and charge-ordering scenarios are suggested as possible reasons for the crystal symmetry change compared with Bi(0.99)Mn(0.99)O(3). BiMnO(3.03) and BiMnO(3.08) are ferromagnetic below T(C) = 82 and 68 K, respectively, with magnetic moments along the monoclinic b axes. Refined magnetic moments at 10 K are 2.88(2)micro(B) in BiMnO(3.03) and 2.33(2)micro(B) in BiMnO(3.08). BiMnO(3.14) (= Bi(0.955)Mn(0.955)O(3)) crystallizes in an orthorhombic system (space group Pnma; Z = 4; a = 5.5136(4) A, b = 7.8069(8) A, and c = 5.5454(5) A at 290 K), and its structure is similar to that of LaMnO(3.11)-LaMnO(3.15). No magnetic reflections were found in BiMnO(3.14) down to 8 K, in agreement with its spin-glass magnetic state. Magnetic and chemical properties of BiMnO(3+delta) (0.02 < or = delta < or = 0.14) have also been investigated and compared with those of LaMnO(3+delta). Systematic changes of magnetic parameters in BiMnO(3+delta) were found to depend on delta.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207051036,"openaccessinfo":{"externalids":{"MAG":"2123720764","ACL":null,"DOI":"10.1021\/ja102014n","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There is increasing evidence of functional lateralization within the rat brain. Here, we have examined the lateralization of dopamine (DA) function in the medial prefrontal cortex (PFC) in relation to memory consolidation in the novel object recognition test (NOR). Male Wistar rats received single bilateral or unilateral injections into prelimbic-PFC of agonists (SKF81297; 0.2\u2009\u00b5g, quinpirole; 1\u2009\u00b5g, SB277,011; 0.5\u2009\u00b5g) and antagonists (SCH23390; 3\u2009\u00b5g, L-741,626; 1\u2009\u00b5g, 7-OH-DPAT; 3\u2009\u00b5g) at DA D1, D2, or D3 receptors, immediately following the exposure trial in the NOR, and were tested either 1 or 24\u2009h later for discrimination between a novel and a familiar object. As previously reported, bilateral injection of a D1 antagonist (SCH23390, 3\u2009\u00b5g\/side), a D2 antagonist (L-741,626, 1\u2009\u00b5g\/side) or a D3 agonist (7-OH-DPAT, 3\u2009\u00b5g\/side) impaired NOR at 1\u2009h, while a D1 agonist (SKF81297, 0.2\u2009\u00b5g\/side), a D2 agonist (quinpirole, 1\u2009\u00b5g\/side) or a D3 antagonist (SB277,011, 0.5\u2009\u00b5g\/side) improved NOR at 24\u2009h. The same effects were seen with left-sided unilateral injections. No effects were seen with right-sided unilateral injections. Endogenous DA release in the prelimbic-PFC promotes memory consolidation in the NOR, but only on the left side of the brain.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":139105240,"openaccessinfo":{"externalids":{"MAG":"2943032856","ACL":null,"DOI":"10.1097\/FBP.0000000000000483","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A lossy-to-lossless compression framework for electrocardiogram (ECG) signals is proposed for wearable monitoring devices. In this framework, the tail bits of the coefficients generated by the lifting discrete wavelet transform of the ECG sequences are truncated at different levels configured according to the tolerance of the information loss, while no truncation for lossless compression. These processed coefficients are then encoded with the modified run length code. The algorithm is evaluated by the MIT-BIH arrhythmia database, where the experimental results show that the proposed framework achieves a better comprehensive performance than existing state-of-the-art lossy-to-lossless compression approaches. The authors further demonstrate a three-stage pipeline very large scale integration (VLSI) implementation of the compression framework, which can be used as an intellectual property core with a core area of 0.4 mm2 and achieves power consumption of 1.524 \u03bcW at 360 Hz in a 0.18 \u03bcm CMOS technology.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":116385371,"openaccessinfo":{"externalids":{"MAG":"2901927536","ACL":null,"DOI":"10.1049\/EL.2018.5014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Scleroderma impairs patients' quality of life and frequently threatens patients' lives. There is still no established treatment for the fibrosis in scleroderma.Elucidation of the underlying cause of this disease has been much awaited. Recently, the matricellular molecules and their associated molecules in skin were suggested to play key roles in scleroderma, and the studies on them are still on-going. Objectives Periostin, a novel matricellular protein, is recently reported to paly a crucial role in tissue remodeling, and highly expressed in fibrotic conditions. This study was undertaken to assess the role of periostin in scleroderma. Methods Using patients and healthy donors' skin tissues, expression of periostin was assessed by immunohistochemistry and immunoblotting analysis. Furthermore, we investigated periostin-\/- (PN-\/-) mice and wild-type (WT) mice to elucidate the role of periostin in scleroderma. To induce murine cutaneous sclerosis, mice were subcutaneously injected with bleomycin, while untreated control groups were injected with phosphate buffered saline. Bleomycin-induced fibrotic changes were compared between PN-\/-and WT mice, by histologic analysis, as well as measuring profibrotic cytokines and extracellular matrix proteins (ECM) expression in vivo and in vitro. To determine the downstream signal transduction pathway for the effect of exogenous periostin, signal-transduction inhibitors were used in vitro. Results Elevated expression of periostin was observed in lesional skin of patients with scleroderma, compared with healthy donors. Regarding the animal experiments, although WT mice showed marked cutaneous sclerosis with increased expression of periostin and increased number of myofibroblasts by bleomycin treatment, PN-\/- mice showed resistant to these changes. In vitro, PN-\/- mice dermal fibroblasts showed reduced transcripts expression of transforming growth factor beta 1 (TGF\u03b21)-induced alpha smooth muscle actin (\u03b1SMA) and procollagen type I alpha 1 (Col1\u03b11). Furthermore, recombinant mouse periostin directly induced Col1\u03b11 expression in vitro, and this effect was inhibited by PI3K\/Akt kinase inhibitor LY294002. Conclusions Periostin plays an essential role in the pathogenesis of scleroderma. Disclosure of Interest None Declared","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":76316605,"openaccessinfo":{"externalids":{"MAG":"2328783844","ACL":null,"DOI":"10.1136\/annrheumdis-2012-eular.1913","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract. The development of the survey techniques for architecture and archaeology requires a general review in the methods used for the representation of numerical data. The possibilities offered by data processing allow to find new paths for studying issues connected to the drawing discipline. The research project aimed at experimenting different approaches for the representation of the rupestrian architecture and the texture mapping process. The nature of the rupestrian architecture does not allow a traditional representation of sections and projections of edges and outlines. The paper presents a method, the Equidistant Multiple Sections (EMS), inspired by cartography and based on the use of isohipses generated from different geometric plane. A specific paragraph is dedicated to the texture mapping process for unstructured surface models. One of the main difficulty in the image projection consists in the recognition of homologous points between image and point cloud, above all in the areas with most deformations. With the aid of the \"virtual scan\" tool a different procedure was developed for improving the correspondences of the image. The result show a sensible improvement of the entire process above all for the architectural vaults. A detailed study concerned the unfolding of the straight line surfaces; the barrel vault of the analyzed chapel has been unfolded for observing the paintings in the real shapes out of the morphological context.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":56438498,"openaccessinfo":{"externalids":{"MAG":"2806101180","ACL":null,"DOI":"10.5194\/ISPRS-ARCHIVES-XLII-2-209-2018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tremendous development of irrigation since the 1960s combined with unbalanced water resources management led to the destruction of the ecosystems in the delta zone and the gradual desiccation of the Aral Sea, once the fourth largest freshwater lake of the world. Command\u2010and\u2010control\u2010based water management in the Aral Sea basin inherited from Soviet times did not create any incentives for investing in improved irrigation infrastructure, adopt water\u2010wise approaches, and thus maintain flows into the Aral Sea. This study examined the potential for market\u2010based water allocation to increase inflows to the Aral Sea while maintaining stable agricultural incomes. We find that a water trading system can improve inflows to the Aral Sea but would require significant compensation for agricultural producers. Agricultural producers can use the compensation payments to cope with reduced water supply by improving irrigation and conveyance efficiencies and by developing alternative rural activities such as livestock grazing, agro\u2010processing, and cultivation of low water\u2010consumptive crops. We also find that a water trading system would be more efficient if it includes both trade among irrigation sites and between sites and instream uses. Copyright \u00a9 2015 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128936966,"openaccessinfo":{"externalids":{"MAG":"1620215747","ACL":null,"DOI":"10.1002\/ldr.2394","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/research-repository.griffith.edu.au\/bitstream\/10072\/173687\/1\/BekchanovPUB836.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The collapsing accidents of greenhouse frames have been increased yearly due to strong wind and heavy snow, but as it was, there were few studies about the structural safety of greenhouses. Therefore, this study was carried out to develop the stress tolerant structural frame systems in built-up greenhouses. The vertical loading experiment of developed scale models were implemented and the developed types of models were simulated by 3-D analysis program in this study. These types of models, which are existing type and honeycomb type, in arch and standard style frames were classified. As a result of this study, it was verified that the honeycomb type model of arch style frame is better than the existing type model of it in stress resistance against snow load and wind load.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":114126853,"openaccessinfo":{"externalids":{"MAG":"2490547454","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The motive of the Internet of Things (IoT) is to monitor and to control the\ndevices that are connected to the internet. In IoT sensory environments, the application queries for the\nphysical quantities in the spatiotemporal domain. The interaction between the sensors and the applications\nfrom the internet is the next big thing in the era of the internet of things. To minimise the resource\nutilisation, task scheduling mechanisms are implemented to the network.\n\n\n\nThe PRITRAPS (Priority-based Task aware Pre-processing and Scheduling) is a mechanism\nthat is employed in real time scenarios of industries. In which different applications units are accessing\nthe gateway unit to measure and monitor the parameters of different service types.\nPRITRAPS employs priority among the tasks to reduce the network load.\n\n\n\n The QoS parameters of the system are analysed and compared with the previous methodologies.\nThe PRITRAPS mechanism consists of a task pre-processor unit, Scheduler and EMS module\nwithin the gateway unit. The scheduling algorithm employed in PRITRAPS is EDF (Earliest Deadline\nFirst) algorithm. The pre-processing task unit decreases the number of tasks by choosing the tasks\nhaving similar spatial and temporal requirements. The residual energy of the sensor nodes can help\nthe scheduler for deciding the sensor nodes in respective of task requirements. The scheduler finds the\nbest potential nodes and assigns them to the task for processing.\n\n\n\nTo reduce the tasks arrivals at the wireless sensor unit, a priority based CCTs (Critical\nCovering Task sets) is proposed, and it effectively reduces the packet congestion and network overload.\nThe results obtained are satisfactory and proven that PRITRAPS outperform TRAPS in energy\nconsumption of a node by processing the tasks on the node. PRITRAPS require only 50 % of the time\nthat has been taken by TRAPS for serving the tasks. The PRITRAPS mechanism is implemented in\nNS3 simulator and tested for different task sets.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":182630458,"openaccessinfo":{"externalids":{"MAG":"2945233969","ACL":null,"DOI":"10.2174\/1872212113666190515120232","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nLymph node dissection in patients with early gastric cancer is controversial because lymph node metastases are much less common than in advanced cancer. Therefore, routine extensive lymph node dissection with wide resection of the stomach may be excessive, and an appropriate lymph node dissection procedure in patients with early gastric cancer should be established.\n\n\nMETHODS\nRetrospectively, 588 consecutive patients with early gastric cancer were analyzed by univariate and multivariate analysis to predict lymph node metastases with clinicopathologic variables. The sites and rates of lymph node metastases for each tumor location were mapped.\n\n\nRESULTS\nIn early gastric cancer, depth of invasion was an independent predictive factor of lymph node metastases. In cancer confined to the mucosa, however, tumor diameter was the only predictive factor. In contrast, tumor diameter, macroscopic appearance, and histologic type were not predictive factors in early gastric cancers invading the submucosa. In mucosal cancer, metastasis to lymph nodes was confined to the paragastric lymph nodes on the same side of the stomach as the tumor. In submucosal cancer, the incidence of lymph node metastasis was 2% to 17% in group 1 and 1% to 3% in group 2 lymph nodes.\n\n\nCONCLUSIONS\nIn mucosal cancer, lymph node dissection is unnecessary for tumors measuring less than 30 mm, and limited lymph node dissection with local gastrectomy is appropriate when tumor diameters are 30 mm or greater. In submucosal cancer, gastrectomy with dissection of group 1 and some group 2 lymph nodes should be sufficient to remove all nodal metastases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26067465,"openaccessinfo":{"externalids":{"MAG":"1969432426","ACL":null,"DOI":"10.1067\/MSY.2001.110222","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We calculate the ground-state energy of a quasi-one-dimensional electron gas with Coulomb interaction depending on the spin-polarization parameter and the Wigner-Seitz parameter . Cylindrical quantum wires of radius are considered. We describe the pair-correlation function g(z = 0) as a function of and . We derive the spin-susceptibility as a function of and in different approximations. Numerical results obtained for the spin-susceptibility are fitted by an analytical expression. Collective modes (charge-density and spin-density excitations) in cylindrical quantum wires are described and the validity range of our calculation is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123028992,"openaccessinfo":{"externalids":{"MAG":"2072915200","ACL":null,"DOI":"10.1088\/0953-8984\/10\/21\/018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Local recurrence after curative resection \nin rectal cancers is one of the most important problems \ncolorectal surgeons encounter and struggle with \nuntil today. While the local recurrence rate after \nconservative curative surgery is between 11.7 and \n37.6%, after total mesorectal excicion (TME) it is \nbetween 1.6 and 17.8%.We aimed to evaluate the \neffect of TME technique on local recurrence and \ndistant metastasis rates in rectal cancer patients \noperated on either with TME technique or conventional \napproaches during the past 10 years in a retrograde \nstudy. Sixty-three patients included into this \nstudy. The patients are divided into two follow-up \ngroups covering the first five years (first group, conventional \nradical rectal excision period) and second \nfive years (second group, TME application period) \nperiods. There were 29 patients (median age of 58 \nyears) in the first and 34 patients in the second (median \nage of 62 years) group. After 2 years of followup, \nthe local recurrence rates were 20.7% (6 patients) \nin the first and 11.8% (4 patients) in the second \ngroup. Metastatic disease was observed in 8 \npatients (27.6%) in the first group and 7 (20.5%) in \nthe second group. It is concluded that TME is a \nmethod easily applied and may be effective in reducing \nthe local recurrence and distant metastasis rates.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":53901332,"openaccessinfo":{"externalids":{"MAG":"1502416542","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes the development of a low-cost multiparameter acquisition system for volcanic monitoring that is applicable to gravimetry and geodesy, as well as to the visual monitoring of volcanic activity. The acquisition system was developed using a System on a Chip (SoC) Broadcom BCM2835 Linux operating system (based on DebianTM) that allows for the construction of a complete monitoring system offering multiple possibilities for storage, data-processing, configuration, and the real-time monitoring of volcanic activity. This multiparametric acquisition system was developed with a software environment, as well as with different hardware modules designed for each parameter to be monitored. The device presented here has been used and validated under different scenarios for monitoring ocean tides, ground deformation, and gravity, as well as for monitoring with images the island of Tenerife and ground deformation on the island of El Hierro.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14978350,"openaccessinfo":{"externalids":{"MAG":"1940426511","ACL":null,"DOI":"10.3390\/s150820436","PubMedCentral":"4570429","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1424-8220\/15\/8\/20436\/pdf?version=1439976918","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"An analytical model has been constructed for an ion propulsion system which performs large changes in the inclination of a satellite in low-earth orbit. A thrusting strategy and the top-level propulsion system design are also presented. The analytical model enables the derivation of requirements for Delta V, propellant, and power. A parametric trade study is presented which explores the relationship of duty cycle and specific impulse to power and propellant requirements. The primary result of this study is a determination of which propulsion system parameters have the greatest effect on overall system performance. It is found that the power processing unit design is the main driver in determining available satellite payload.<>","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":2}},"corpusid":151893422,"openaccessinfo":{"externalids":{"MAG":"2543976983","ACL":null,"DOI":"10.1109\/AERO.1991.154530","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Common peripheral neuropathies do not usually cause diaphragmatic weakness and subsequent respiratory compromise. However, respiratory involvement is relatively common in Guillain\u2010Barr\u00e9 syndrome (GBS). Experience in GBS has led to a standardized approach to manage respiratory problems in peripheral neuropathies. Diaphragmatic weakness is not common in chronic inflammatory demyelinating polyneuropathy and extremely rare in multifocal motor neuropathy. The linkage has been described between certain subtypes of Charcot\u2010Marie\u2010Tooth (CMT) disease such as CMT2C and CMT4B1 and diaphragmatic weakness. A correlation usually has not been found between electrophysiologic findings and clinical respiratory signs or spirometric abnormalities in peripheral neuropathies except in amplitudes of evoked phrenic nerve responses. Careful and frequent assessment of respiratory function by a qualified team of healthcare professionals and physicians is essential. Criteria established for mechanical ventilation in GBS cases may be applied to other peripheral neuropathies with respiratory compromise as necessary.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42975592,"openaccessinfo":{"externalids":{"MAG":"1997741806","ACL":null,"DOI":"10.1111\/j.1529-8027.2010.00293.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we proposed a multiple-instance neural network (MINN) for content-based image retrieval (CBIR). In order to represent the rich content of an image without precisely image segmentation, the image retrieval problem is considered as a multiple-instance learning problem. A set of exemplar images are selected by a user, each of which is labelled as conceptual related (positive) or conceptual unrelated (negative) image. Then, the proposed MINN is trained by using the proposed learning algorithm to learn the user's preferred image concept from the positive and negative examples. Experimental results show that: (1) without image segmentation and using only the color histogram as the image feature, the MINN without relevance feedback performs slightly inferior to some leading image retrieval methods, and (2) the MINN with the relevance feedback can significantly improve the retrieving performance from 40.3% to 59.3%, which outperforms to the results of some leading image retrieval methods","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":18319018,"openaccessinfo":{"externalids":{"MAG":"2141292664","ACL":null,"DOI":"10.1109\/ICICIC.2006.204","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. The spatial distribution of excitatory and inhibitory synapses on cultured Purkinje cells was studied with fluorescence, scanning electron microscopy (SEM), and electrophysiological techniques. 2. Presynaptic terminals were identified with immunohistochemical staining of synaptophysin and the results were correlated with SEM micrographs. 3. Excitatory and inhibitory inputs onto the Purkinje cell were identified from the direction and pharmacology of the postsynaptic current. 4. The localization of the presynaptic terminals on the Purkinje cell was observed after electrophysiological identification by filling the presynaptic neuron with Lucifer yellow and the Purkinje cell with Texas red. 5. The axon and presynaptic terminals of excitatory and inhibitory inputs had a different spatial organization. Excitatory inputs from granule cells were exclusively localized on the dendrites of Purkinje cells, whereas inhibitory contacts were found on both the soma and dendrites. This result is similar to that described in vivo.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":33608779,"openaccessinfo":{"externalids":{"MAG":"2279066852","ACL":null,"DOI":"10.1152\/JN.1993.70.4.1316","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two disturbing trends are arising within the computer science research community: increasing occurrences of double submissions by authors and irresponsible attitudes among professional service volunteers with regard to their service assignments. Here, the author suggests that one of the relevant professional societies\u2014such as IEEE\u2014take leadership in addressing this issue by creating a committee that would track and publicize such behaviors to create backpressure against them and reverse these negative trends. Moreover, an existing mechanism within IEEE that handles plagiarism complaints could provide the foundation for the broader misconduct committee proposed here.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":19858281,"openaccessinfo":{"externalids":{"MAG":"2053774699","ACL":null,"DOI":"10.1109\/MIC.2012.104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Now that the front page belongs to George Bush, what are analysts saying about Ronald Reagan? And how will the Reagan legacy shape policy and politics into the next century? \"Looking Back on the Reagan Presidency\" offers the latest thinking of nineteen leading president-watchers. Edited by Larry Berman, the volume appraises the administration's policies and initiatives and speculates about what the Reagan years will mean to the future. Robert Pastor describes Reagan's failure in Latin America and the problems that remain for Bush. Condoleezza Rice examines the unexpected transformation of relations with the Soviets. Walter Murphy looks at Reagan's far-reaching impact on the courts. Additional discussions of congressional relations, tax policy, electoral politics, the institution of the presidency-- and an insightful Afterword by Richard Neustadt-- make this a challenging and comprehensive look at the \"Reagan Revolution\". No president since F.D.R. so redefined the parameters of political debate in America. Yet for all his popular success, Reagan's lasting influence is far from clear. What will his legacy mean to future generations? \"Looking Back on the Reagan Presidency\" is a fascinating preview from the scholars who will find the history in the Reagan years.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153025361,"openaccessinfo":{"externalids":{"MAG":"1496986088","ACL":null,"DOI":"10.2307\/20044532","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Solar cells, consisting of core-shell p-n junction silicon micropillars on a thin membrane fabricated using soft lithography and metal-assisted chemical etching, are studied as a function of geometrical designs. Significant enhancement in absorption rate is found without much dependence on the pillar diameters in the range of 0.5-2 \u03bcm. However, the short-circuit current increases continuously with diameter, which is inversely proportional to the total surface area for a fixed diameter\/pitch pillar array. This study provides unambiguous evidence that surface recombination is the dominant loss mechanism in nanowire- or micropillar-based solar cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":404967,"openaccessinfo":{"externalids":{"MAG":"2045107740","ACL":null,"DOI":"10.1109\/JPHOTOV.2011.2180894","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The Esterh\u00e1zy Collection, which includes masterpieces of sixteenth- and seventeenth-century European and Ottoman textiles and goldsmiths' work, is the most valuable collection in the Hungarian Museum of Applied Arts, Budapest, Hungary. The collection remained in fairly good condition until the Second World War when it was evacuated to the cellars of an Esterh\u00e1zy palace, which collapsed under heavy bombardment in 1944. The treasures lay in the muddy ruins until 1948, when their remains were transferred to the museum. The conservators did their best to provide basic, rapid cleaning but the methods used were not appropriate in every case. However, cleaning and conservation activities have continued since the early 1950s. Most textiles are decorated with metal threads, with gilded silver, and silver threads serving as weft and warp, and as the basic materials of lace, trimmings, buttons, and strings. Metal threads were used extensively on the richly embroidered saddle-cloths described in this paper. Most of the artefacts suffered irreversible changes during the time they spent underground: textile backings deteriorated, resulting in the detachment and deformation of the metal thread embroidery. This paper shares the experience gained in cleaning, conserving, and restoring the saddle-cloths, and explains the complex and sometimes insoluble problems encountered with the metal thread embroideries.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":190698467,"openaccessinfo":{"externalids":{"MAG":"2138857410","ACL":null,"DOI":"10.1179\/2047058412Y.0000000056","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Patients with biliary tract obstruction have unexplained, inordinately high rates of perioperative morbidity and mortality, whereas cholestatic animals display abnormal hypothalamic responses to pyrogenic stimuli. We asked if obstructive cholestasis was associated with abnormal fever generation. Male Sprague-Dawley rats (250 g) underwent laparotomy for implantation of thermistors and either bile duct resection (BDR) or sham operation. After recovery, temperatures were recorded by telemetry and conscious, unrestrained rats in each group were injected intraperitoneally with either interleukin-1beta (IL-1beta;1 microg\/kg) or Escherichia coli lipopolysaccharide (LPS; 50 microg\/kg). Baseline temperatures in both groups were similar. Febrile responses after IL-1beta injection in BDR and sham groups were not significantly different. However, in response to LPS injection, BDR rats showed an initial hypothermia with a subsequently attenuated febrile response. Administration of anti-tumor necrosis factor-alpha (TNF-alpha) antibody 2 h before LPS injection blocked the LPS-induced hypothermia seen in BDR animals. However, serum levels of TNF-alpha were not significantly different between sham and BDR animals after LPS injection at any time point measured (0, 1.5, and 3 h).","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":6539983,"openaccessinfo":{"externalids":{"MAG":"2154670234","ACL":null,"DOI":"10.1152\/AJPGI.2000.279.1.G172","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examined a mediating model of income and pay satisfaction with a direct path (income \u2192 pay satisfaction) and an indirect path with two mediators (income \u2192 the love of money \u2192 pay equity comparison \u2192 pay satisfaction). Results of the whole sample showed that the indirect path was significant and the direct path was insignificant. When the indirect path was eliminated, income contributed positively to pay satisfaction. We then tested the model across two moderators: culture (the United States versus Spain) and gender. This study provides the following theoretical and empirical contributions: the direct relationship between income and pay satisfaction depends on the indirect path and the extent to which (1) income enhances the love of money and (2) the love of money is applied to evaluate pay equity comparison satisfaction. If both conditions exist, income leads to pay dissatisfaction. If the second condition does not exist, income does not lead to pay dissatisfaction. Pay satisfaction depends on (1) one's love of money and (2) how one compares. The role of the love of money in pay satisfaction is \"not\"universal across cultures and gender.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":155040143,"openaccessinfo":{"externalids":{"MAG":"2078408020","ACL":null,"DOI":"10.1108\/15365430580001311","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT In previous work, a periodic surface model for computeraided nano-design (CAND) was developed. This implicit surface model can construct Euclidean and hyperbolic nano geometries parametrically and represent morphologies of particle aggregates and polymers. In this paper, we study the characteristics of degree elevation and reduction based on a generalized periodic surface model. Methods of degree elevation and reduction operations are developed in order to support multi-resolution representation and model exchange.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":7492093,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Early-morning flowering (EMF) trait is supposed to be effective in retaining grain yield due to mitigation of heat-induced spikelet sterility at flowering in rice. This study evaluated (i) phenotypic differences between a near-isogenic line carrying a QTL for EMF trait, designated as IR64+qEMF3, and a recurrent parent, IR64, under wide variation in climates and (ii) whether an EMF trait can retain grain yield under heat stress at flowering. IR64+qEMF3 had significant earlier flower opening time (FOT) in diverse environmental conditions including temperate, subtropical, and tropical regions. Under normal temperatures at flowering, IR64+qEMF3 had similar grain yield to IR64 with some significant changes in agronomic traits and yield components. Field trials in heat-vulnerable regions of central Myanmar for seven crop seasons showed that higher percentage of filled grains contributed to the significantly higher grain yield in IR64+qEMF3 among yield components when plants were exposed to daily maximum air temperatures around 36.5 \u00b0C or higher. Lower spikelet sterility in IR64+qEMF3 was attributed to the earlier FOT during cooler early morning hours. This is the first field study that clearly demonstrates the advantage of the EMF trait for retaining grain yield by stabilizing percentage of fertile grains under heat stress at flowering.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231666914,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1101\/2021.01.16.426929","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1101\/2021.01.16.426929","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Ribbon lattices are kind of transition systems in between one and two dimensions, and their study is crucial to understand the origin of different emerging properties. In this work, we study a Lieb ribbon lattice and the localization-delocalization transition occurring due to a reduction of lattice distances (compression) and the corresponding flat band deformation. We observe how above a critical compression ratio the energy spreads out and propagates freely across the lattice, therefore transforming the system from being a kind of insulator into a conductor. We implement an experiment on a photonic platform and show an excellent agreement with the predicted phenomenology. Our findings suggest and prove experimentally the use of compression or mechanical deformation of lattices to switch the transport properties of a given system.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":244205474,"openaccessinfo":{"externalids":{"MAG":"3204264482","ACL":null,"DOI":"10.21203\/rs.3.rs-916796\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-916796\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In this paper, after a general overview of the economic situation of the new EU countries of 2004, we start by studying the foreign direct investment (FDI) by economic sector in the three Baltic countries (Estonia, Latvia and Lithuania), the five Central countries (Czech Rep., Poland, Hungary, Slovakia and Slovenia), besides Cyprus and Malta. In second place, we will monitor the potential and performance FDI indices for acceding countries and for Spain, Portugal and Greece. Finally, we present some conclusions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":166698625,"openaccessinfo":{"externalids":{"MAG":"1495880108","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Machine learning techniques are immensely deployed in both industry and academy. Recent studies indicate that machine learning models used for classification tasks are vulnerable to adversarial examples, which limits the usage of applications in the fields with high precision requirements. We propose a new approach called Feature Map Denoising to detect the adversarial inputs and show the performance of detection on the mixed dataset consisting of adversarial examples generated by different attack algorithms, which can be used to associate with any pre-trained DNNs at a low cost. Wiener filter is also introduced as the denoise algorithm to the defense model, which can further improve performance. Experimental results indicate that good accuracy of detecting the adversarial examples can be achieved through our Feature Map Denoising algorithm.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":220495747,"openaccessinfo":{"externalids":{"MAG":"3041075201","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2007.05573"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a dual-buck full-bridge inverter (DBFBI) to solve the shoot-through problem in conventional bridge-type inverters and reduce the voltage stress of the power device in the dual-buck half-bridge inverter (DBHBI). Hysteresis current control is used in the DBFBI. All switches and diodes operate at each half line cycle, and the freewheeling current flows through the independent freewheeling diodes instead of the body diodes of the switches, so the efficiency can be increased potentially. As the shoot-through problem does not exist in the DBFBI, dead time between the switches need not be set. The input-voltage utilization rate of the DBFBI is twice that of the DBHBI under the same output-voltage condition, i.e., the voltage stress of the power device in DBFBI is half that in the DBHBI. The operating principle, stability and relative stability analyses, and design guidelines and example are provided. Experimental results of a 1-kVA DBFBI verify the theoretical analysis. The comparisons among other inverters and the DBFBI show that the proposed inverter is very promising in 220-240-Vrms output-voltage and high-reliability applications, such as uninterruptible power supplies and grid-connected inverters.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":2}},"corpusid":1344492,"openaccessinfo":{"externalids":{"MAG":"2162989706","ACL":null,"DOI":"10.1109\/TIE.2009.2022072","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo determine whether cardiac transplantation improves the natural history of infants with hypoplastic left-heart syndrome and to examine differences in outcome as a function of the pretransplant period.\n\n\nDESIGN\nRetrospective cohort study. Historical, clinical, and laboratory data were collected during the pretransplant period, the in-hospital period, and for up to 6 years following transplantation. Data were analyzed using the product-limit estimate and the log rank test.\n\n\nSETTING\nA tertiary, acute care, university teaching hospital.\n\n\nPATIENTS\nAll 111 infants with hypoplastic left-heart syndrome who entered and completed a protocol leading to transplantation from November 19, 1985, to December 31, 1991. Infants who died while waiting for transplantation were included.\n\n\nINTERVENTION\nOrthotopic cardiac allotransplantation.\n\n\nMAIN OUTCOME MEASURES\nPretransplant waiting mortality and its influence on posttransplant survival, operative (in-hospital or within 30 postoperative days in discharged patients) and intermediate-term mortality (5 years), and reoperation rates for cardiac surgery.\n\n\nRESULTS\nTransplantation procedures were performed in 84 infants (76%; 95% confidence interval [CI], 66% to 83%) ranging in age from 3 hours to 151 days. Twenty-seven infants registered for transplantation died while awaiting a donor heart. Operative mortality was 13% (CI, 7% to 23%), and 69 patients were late survivors (62% [CI, 52% to 71%] of the study group and 82% [CI, 72% to 89%] of the transplant recipients). Overall 5-year actuarial survival was 61% (CI, 52% to 70%). Transplant recipients had a 5-year survival of 81% (CI, 71% to 88%). Freedom from reoperation was 89% (CI, 76% to 95%) at 5 years.\n\n\nCONCLUSIONS\nCardiac transplantation for hypoplastic left-heart syndrome has a significant positive impact on the natural history of this uniformly lethal lesion.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":26573497,"openaccessinfo":{"externalids":{"MAG":"1981588763","ACL":null,"DOI":"10.1001\/JAMA.1993.03510240056032","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using the Adapted Questionnaire of Soccer Athlete's Motivation and Health Related Behaviors -Chinese Version (AQSAMHRB), this study examined essential factors that motivate youth athletes to participate in soccer practices and competitions. Participants included 98 male soccer athletes (aged 14\u201315) from 10 middle schools of Jiangsu province, China. Data analysis included descriptive statistics and a 2 (Supporting: By Parents or By School) \u00d7 2 (Goal-Setting: For Professional or For Non-Professional) MANOVA. The top three scores from the 18 motivation factors (MFs) in the AQSAMHRB included MF1, high technical content and unique value, M = 4.73; MF4, to meet friends, M = 4.42; and MF2, for fun, M = 4.34. The 2 \u00d7 2 MANOVA revealed no significant difference in Supporting, p > .32, \u039b = .79, F = 1.16, but a significant difference in Goal-Setting, p < .00, \u039b = .03, F = 143.61. The follow-up MANOVA discovered that 12 of the 18 MF comparisons in Goal-Setting showed significant difference at p < .05, with For Professional scoring higher than For Non-Professional (e.g., MF6, to contest winners; MF7, to shape the body; MF9, to become\u00a0 a professional; and MF17, to become a coach). In brief, intrinsic and extrinsic MFs significantly affected these soccer athletes' motivations. It did not matter who supported their participation, but it was their Goal-Setting on becoming a Professional or Non-Professional athlete that mattered. On the other hand, for the 27 health-related behaviors in the AQSAMHRB, frequency and percentage data were analyzed and summarized. Findings from this aspect provide firsthand information about the youth soccer athletes' eating habits, nutrition knowledge and status, risk behaviors, and hygiene behaviors. A meaningful discussion from an educational perspective has also been provided. Subscribe to TPE","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":116636925,"openaccessinfo":{"externalids":{"MAG":"2923129644","ACL":null,"DOI":"10.18666\/TPE-2019-V76-I2-8499","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present work, a computer aided classification system has been proposed for classification of mammogram images into normal, benign and cancer classes. The work has been carried out on thirty Digital Database for Screeningmammography(DDSM) cases consisting of 10 normal, 10 benign and 10 cancer images. The regions of interest (ROI) have been extracted from the right Medio Lateral Oblique (RMLO) part of the mammogram. We extracted 256\u00d7256 pixel size ROI from each case. Texture descriptors based on gray level co-occurrence method by varying the value of inter pixel distance 'd' from 1 to 8 have been used. The SVM classifier has been used for the classification task. The result of the study indicates that GLCM mean and range features computed at d=1 yield the maximum overall classification accuracy of 75% and 65 % respectively.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":174785832,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper introduces a tracking method for the well known local MSER (Maximally Stable Extremal Region) detector. The component tree is used as an efficient data structure, which allows the calculation of MSERs in quasi-linear time. It is demonstrated that the tree is able to manage the required data for tracking. We show that by means of MSER tracking the computational time for the detection of single MSERs can be improved by a factor of 4 to 10. Using a weighted feature vector for data association improves the tracking stability. Furthermore, the component tree enables backward tracking which further improves the robustness. The novel MSER tracking algorithm is evaluated on a variety of scenes. In addition, we demonstrate three different applications, tracking of license plates, faces and fibers in paper, showing in all three scenarios improved speed and stability.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":206590641,"openaccessinfo":{"externalids":{"MAG":"2105666116","ACL":null,"DOI":"10.1109\/CVPR.2006.107","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The 200-billion-dollar per annum online advertising ecosystem has become infested with thousands of intermediaries exploiting user data and advertising budgets. All key stakeholders in the value-chain are infected: advertisers with fraud, publishers with their diminishing share of advertising budgets, and users with their right to privacy. Blockchain presents a possible solution to addressing the critical issues in the online advertising supply chain. The question remains whether blockchain scalability, energy-efficiency, and token volatility issues can be solved in the coming years to the extent that online advertising could widely leverage trustlessness and the benefits gained from blockchain technology. This paper aims to review the current progress and to open a discussion to address the issues. We present new requirements for blockchain-based online advertising solutions. We have also analyzed the available solutions against the requirements and recommend directions for future research and solution development. Evidence from our research points out that blockchain is not yet ready to be widely implemented in online advertising. More research is needed, and new proof-of-concepts need to be developed before blockchain technology can be considered a trusted alternative for the current online advertising marketplace based on open real-time bidding.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":3,"dup_details":{"curated_sources":1,"2024-26":1,"2024-18":1,"2024-30":1}},"corpusid":53016237,"openaccessinfo":{"externalids":{"MAG":"2895437861","ACL":null,"DOI":"10.1109\/ACCESS.2018.2872694","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : The Rim-of-the-Pacific (RIMPAC) naval exercise is a biennial multi-week multinational naval exercise that has been undertaken around the main Hawaiian Islands since 1968. Immediately prior to the 2004 RIMPAC exercise a group of 150-200 melon-headed whales, Peponocephala electra, a species that is typically found in deep waters in Hawai'i, entered Hanalei Bay on the north shore of the island of Kaua'i, and remained in the bay for more than 24 hours (Southall et al. 2006). While the exact cause of the event remains unknown, a review of available evidence concluded that active sonar transmissions by naval vessels prior to and during the period when the whales were inside the bay were a likely, if not plausible, contributing factor (Southall et al. 2006). Considerable uncertainty remains regarding the cause(s) of this event in part because no information is available on where the group of melon-headed whales was prior to the initiation of sonar use. This example illustrates the difficulty in understanding, assessing, and\/or predicting the potential reactions of cetaceans to naval sonar use. Such assessment is problematic for a variety of reasons, including: limited observations of cetaceans before and during active sonar operations; inter-specific variability in reactions (beaked whales appear to be more susceptible to impacts than other cetaceans, see Cox et al. (2006) for a review); likely variable reactions depending on type and number of sound sources and the proximity of individual cetaceans to the sound sources; and potential intra-specific variability in reactions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":127685088,"openaccessinfo":{"externalids":{"MAG":"233888642","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Guselkumab treatment outcomes and persistence were assessed in a real-world cohort of Finnish patients with difficult-to-treat plaque psoriasis over a median follow-up of 1 year. Data on 181 patients who initiated guselkumab at the 15 study centres were collected retrospectively from the patient charts. Prior exposure to biologic therapies was common, with 56% and 35% having used at least 1 and 2 biologics, respectively. Median guselkumab treatment duration was 11 months with 21 patients (12%) discontinuing treatment during follow-up. Of 85 patients with a follow-up duration of at least 1 year, 73 (86%) were still on guselkumab at 1 year. Significant improvements during follow-up were seen in the absolute Psoriasis Area and Severity Index (PASI) scores with 32 patients (80%) having absolute PASI \u2264 2 after a 9\u201314-month treatment. Guselkumab treatment was effective and treatment persistence was high in the nationwide Finnish real-life setting.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253625796,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2340\/actadv.v101.910","PubMedCentral":"9631278","ArXiv":null},"license":"CCBYNC","url":"https:\/\/medicaljournalssweden.se\/actadv\/article\/download\/910\/2190","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"It is a challenging problem to automatically register the SAR and optical satellite images in remote sensing applications. In this paper, a novel intensity based multiscale registration method using steerable Simoncelli filters is proposed to register JERS-1 SAR and ASTER images. The mutual information is used as the similarity measure, and a hybrid search technique is used to do the parameter optimization. The experimental results showed that the proposed registration scheme is competent for JERS-1 SAR and ASTER images, though the robustness of this scheme should be verified further more.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-11":1}},"corpusid":5971294,"openaccessinfo":{"externalids":{"MAG":"2119281638","ACL":null,"DOI":"10.1109\/IGARSS.2007.4422810","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In 1994, five made for television movies \u2013 Hercules and the Amazon Women by Bill L. Norton, Hercules and the Lost Kingdom by Harley Cokeliss, Hercules and the Circle of Fire by Doug Lefler, Hercules in the Underworld by Bill L. Norton and Hercules in the Maze of the Minotaur by Josh Becker \u2013 became the forerunners of two popular, even cult, series screened from the mid-1990s: Hercules: The Legendary Journeys (Various, 1995\u20131999) and its spin-off Xena: Warrior Princess (Various, 1995\u20132001). Despite being set in a mythical Ancient Greece, the movies and the subsequent programmes were filmed on location in New Zealand. Indeed, New Zealand has become a frequent site for fantasy cinema and television production, perhaps most notably through the work of Peter Jackson, and Film New Zealand have actively promoted the country's potential to be 'many worlds'. The varied and dramatic topography has played a significant role in encouraging filmmakers to base their productions in the country, but New Zealand's own mythology as a land of Edenic, untouched beauty and its relative 'youth' are also integral to understanding its appeal. This article, which primarily focuses on the five Hercules films, will explore the unique relationship and the dynamic interaction between the classical\/fantasy narrative and New Zealand.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":162011184,"openaccessinfo":{"externalids":{"MAG":"2004954855","ACL":null,"DOI":"10.1386\/ajpc.2.3.351_1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Desert oasis wetlands are distributed along the Heihe River, especially in lowland oases along the middle reach of the river, in northwestern China. Landscape maps of the wetlands in 1990, 1995, 2000, and 2006 were compiled based on data collected from Landsat TM and ETM+ images using GIS and analyzed in July 2008. Various landscape indices were calculated using the landscape structure analysis software FRAGSTATS, at both class and landscape levels. The results showed that floodplain wetland is the dominant type of wetlands in the middle reach of the Heihe River, followed by non-forested peatland, then river and reservoir wetland, with the proportion of shrub-dominated wetland low. During these 16 years, the area of wetlands in our study area decreased by 38.4%, or 107.8 km2. The major type of wetland lost in the study area was non-forested peatland during the first five years, but floodplain wetland since then. The landscape pattern shows that the fragmentation level is very high, especially in the floodplain wetlands: the patch density increased by 154% during the study period. It is clear that the wetlands along the middle reach of the Heihe River have become increasingly fragmental during the past 16 years.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128401916,"openaccessinfo":{"externalids":{"MAG":"1987624703","ACL":null,"DOI":"10.1080\/15324981003741707","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper investigates that polarizations of a laser vary in the process of reflections after a linearly or circularly polarized beam is incident on a paraboloid of revolution-shaped cavity. This analysis is based on the viewpoint of geometry optics because the opening radius is about 100\u03bcm, which is ten times the size of the wavelength 10.6\u03bcm of an incident CO2 laser beam. Considering the profile of laser beam to be Gaussian distribution, the variation of polarization in the process of reflections is mathematically modeled. The result reveals that the state of polarization for an incoming ray with circular polarization is almost totally transformed into linear polarization perpendicular to the plane of incidence after the ray intervenes multiple reflections. The effects of cavity depth and absorptive index of material on the polarization variation are also discussed. The circularly polarized ray entering the deeper cavity is finally changed into the higher degree of linear polarization. The increase in absorptive index reduces the speed approaching the linear polarization.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119350153,"openaccessinfo":{"externalids":{"MAG":"1966673517","ACL":null,"DOI":"10.4028\/www.scientific.net\/KEM.364-366.193","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Significant enhancements of electrocatalytic activities for both half-reactions of water-electrolysis, i.e., oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), as well as pseudocapacitive charge-storage properties are demonstrated upon changing the structural order in a perovskite-type system. The structural change is prompted by the increase in the ionic radius of the A-site ion in A2Fe2O5. The structure of Sr2Fe2O5 consists of alternating layers of FeO6 octahedra and FeO4 tetrahedra, whereas Ba2Fe2O5 comprises seven different coordination geometries for Fe. We note that the catalytically active metal, i.e., iron, and the oxygen stoichiometry are the same for both materials. Nevertheless, the change in the structural order results in significantly greater electrocatalytic activity of Ba2Fe2O5, manifested in smaller overpotentials, smaller charge-transfer resistance, greater electrocatalytic current, and faster reaction kinetics. In addition, this material shows significantly enhanced pseudocapacitive properties, with greater specific capacitance and energy density compared to Sr2Fe2O5. These findings indicate the important role of structural order in directing the electrochemical properties.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260754443,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/molecules28165947","PubMedCentral":"10459622","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1420-3049\/28\/16\/5947\/pdf?version=1691496424","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Dental Class II is the most common indication for combined orthodontic-orthognathic treatment. Intermolar mandibular distraction osteogenesis (IMDO) treatment was performed during the growth spurt, to avoid surgery at a later age. The aim of this study is to present our first experience with IMDO. Methods: This is a retrospective case series of patients who underwent an IMDO. All patients showed mandibular retrognathism, and orthodontic treatment with functional appliances was not successful. Results: In total, 20 patients (mean age of 14.8 years (SD = 0.9 ys) were included. All patients achieved a Class I occlusion. An average length gain of 9.6 mm (SD = 3.7 mm) was reached. In one patient an abscess occurred. Nine patients presented with root fractures of the second molar; three were lost, one treated endodontically. The average time between insertion and removal of the distractors was 4.6 months (SD = 1.5 mths). In one case a premature consolidation was seen. Conclusion: We achieved satisfactory results with IMDO, although undesirable effects occurred. An advantage is the manageable overall treatment time. Open questions concern the occurrence of root fractures. Furthermore, the question of long-term stability is open. The question of dynamic distraction treatment in relation to temporomandibular joint changes can only be answered in the long term.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":237989405,"openaccessinfo":{"externalids":{"MAG":"3176499394","ACL":null,"DOI":"10.3390\/app11094118","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2076-3417\/11\/9\/4118\/pdf?version=1619774227","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Several evidences, typical of a superfluorescence effect, have been obtained for the first time under continuous excitation. Emission from Er3+ in LiYF4 at 10 K is obtained at 2.72 \u03bcm with a threshold of 3 mW of absorbed power at 6470 A.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":120649663,"openaccessinfo":{"externalids":{"MAG":"2018655335","ACL":null,"DOI":"10.1209\/0295-5075\/7\/5\/014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"To the Editor: E lectroconvulsive therapy (ECT) is a safe and effective treatment that is useful in the treatment of an often treatmentresistant psychiatric illness. Monoamine oxidase inhibitors (MAOIs) may be considered as an option for patients who have failed other antidepressant therapies in maintenance treatment after ECT. A wellknown complication of ECT is asystole. Many facets of the clinical administration and anesthesia of ECT have been examined in their relation to ECT-related asystole. A subconvulsive stimulus, bilateral electrode placement, hyperkalemia, etomidate, succinylcholine, and high-dose serotonin norepinephrine reuptake inhibitors have been suspected of promoting asystole in some ECT patients. Selective serotonin reuptake inhibitors, tricyclic antidepressants, and serotonin norepinephrine reuptake inhibitors possess documented mechanisms of cardiosuppression. In this case, we present a case where a newly started MAOI may have contributed to the occurrence of asystole in an ECT patient. Patient 1 is a 65-year-old woman with major depressive disorder. She has a history of hypertension, well controlled, but is otherwise healthy, maintaining a steady program of physical exercise (swimming). She has had 3 courses of ECT. Her first 2 courses proceeded without complication. Several months after her second treatment, she was noted to be decompensating despite therapeutic levels of nortriptyline plus lithium carbonate. These medications were discontinued, and a trial of phenelzine at 15 mg 3 times a day was begun. Three weeks after starting phenelzine, her treatment team recommended her third course of ECT. It was decided that this course would be given using bilateral electrode placement. During the second treatment of the patient's third course, she experienced an episode of asystole. Medications at the time of treatment included newly started phenelzine 15 mg 3 times a day, amlopidine mesylate-benazapril HCl 5 mg to 20 mg daily, and omeprazole magnesium 20 mg daily, in addition to supplemental vitamins. Anesthesia was unchanged from her prior treatments and consisted of methohexital 70 mg and succinylcholine 60 mg. Her first stimulus, 80 mC, was bilateral and subthreshold, and she immediately experienced an episode of asystole lasting 20 seconds. With intravenous atropine 0.4 mg, the patient recovered into a period of bradycardia and then normal sinus rhythm. The patient then received a second stimulus, 256 mC, that induced a well-modified seizure without any unexpected arrhythmias. On the third and fourth treatments of her second course, patient 1 experienced significant bradycardic events immediately after ECT stimuli, both 256 mC, despite pretreatment with atropine 0.4 mg. What might have contributed to asystole in this patient? One obvious change that could be suspected is that the patient's third course of ECTwas given using bilateral electrode placement, whereas her second course was performed with unilateral electrode placement. Bilateral electrode placement has not been clearly shown to increase the risk of asystole in ECT, although there is some data that suggest this. Her first course was bilateral and uncomplicated. Subconvulsive stimulus has also been shown to be associated with cases of asystole, but this would not explain bradycardia in subsequent treatments, as the remainder of stimuli after the first were fully at suprathreshold. Although we cannot be sure that the bradycardic events occurred via the same mechanism as the asystole, it is likely that the vagal mechanism was involved in some fashion. Early poststimulus electrocardiogram is not available in this case, sowe cannot rule out that the subsequent bradycardia was not compensatory. Compensatory bradycardia did not occur in any treatments before phenelzine initiation. Monoamine oxidase inhibitors have been examined in their relation to ECT outcomes. In 1961, Muller randomized 100 ECT patients to receive either phenelzine or placebo in conjunction with ECT. No increase in adverse events was noted in the patients given phenelzine. Monaco and Delaplaine looked at complications in patients given tranlycypromine and ECT versus placebo and ECTand did not find an increased rate of complication. Neither of these studies commented on anesthesia. In a 2002 prospective study looking at potential risks associated with MAOIs and ECT, no differences were noted between the study and control groups. The authors of this study, however, cautioned that the study group was chosen from patients established on long-term MAOI therapy and that yet undiscovered interactions may occur in patients newly started on MAOIs receiving ECT. In 2004, Dolenc et al presented 4 additional cases of established MAOI patients receiving ECT without an increase in complications. Reports of MAOI-related ECT complications are sparse, at best. In 1969, Bodley et al reported a case in which a 31-yearold woman on phenelzine received ECT and experienced an exaggeration of respiratory depression. The patient was found to have depressed levels of plasma cholinesterases, which normalized after phenelzine was stopped. Phenelzine is known to reduce serum levels of plasma cholinesterases in some patients, and one could postulate a potentiation of the cardiosuppressive effects of succinylcholine in this patient's episode of asystole. However, she did not experience prolonged emergence from muscle relaxation, and serum cholinesterase activity was not measured in this case. If indeed this phenomenon is associated with recently initiated MAOI therapy, treating physicians would be wise to consider alternatives to succinylcholine such as rocuronium. This case also raises questions related to other mechanisms of potentiation of the risk of asystole in ECT patients newly started on or stable on MAOIsVa situation that will occur more frequently, as this class of drugs sees a resurgence of use in mainstream psychiatry. Our patient practices endurance swimming. Regular aerobic exercise increases vagal tone and has been shown to do so in postmenopausal women. This may have, at least in part, predisposed our patient to an exaggerated vagal response to ECT stimulus. Research supports this by suggesting that up-regulation of nitric oxide production in trained athletes increases the vagal response to exercise. Perhaps a direct receptor or unknown catecholamine-related cardiosuppressive effect, as known in other classes of antidepressants, could also have contributed to the appearance of asystole and bradycardia in this patient. Given the sparse literature documentation of the interactions between newly started MAOIs, ECT, and current anesthesia, further investigation of this clinical scenario seems warranted. LETTERS TO THE EDITOR","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":207759614,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A rapid LAMP detection method with primers designed on genus-specific region identified in the gyrA gene was established in this assay. All four Campylobacter jejuni from different sources were detected positive and fourteen non Campylobacter bacteria were negative, which shows excellent specificity of the primers. Compared with plate count and PCR method, the LAMP method and the PCR method had equal sensitivity, which were three orders of magnitude higher than plate count. In this assay, we also found out that the treatment of DNase could reduce the dead bacteria DNA effectively. The LAMP detection on chicken indicated relatively good result on detection of Campylobacter jejuni combining with treatment of DNase.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":237021083,"openaccessinfo":{"externalids":{"MAG":"3149535573","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tourism is a major source of income and also a catalyst for the economic development in Malaysia. Sarawak like other states in Malaysia has realized the importance of tourism contribution to the local economic development and communities. One of the important tourism activities in Sarawak that offers great potentials to generate income to the local communities is home stay program. A home stay program is a community-based tourism initiative and has been identified and prioritized by the state agency as strategic to further progress the tourism sector in Sarawak. In the literature, there has been a lack of research that examines the engagement of ICTs to advance the home stay program in the context of Sarawak. This study aims to address this limitation. This research investigates in what ways ICTs have been engaged in developing and promoting a community-based tourism program and how the home stay operators participate in the process of integrating ICT to enhance this program. More explicitly, this study attempts: (l) to identify initiatives in engaging ICT in developing and promoting a community-based tourism program in the context of Sarawak; (2) to identify factors (perceived benefits, perceived higher cost, ICT knowledge and skills, accessibility to the ICT infrastructure, government support and community support) and determine its relationship with the home stay operators in taking initiative to adopt and use ICT in their context and (3) to provide recommendations to strengthen this business. To obtain data, this study deployed a survey method 102 questionnaires were distributed to selected respondents from seven (7) selected home stay programs in Sarawak namely: Kampung Santubong, Kampung Annah Rais, Kampung Panglima Seman Lama, Kampung Benuk, Kampung Siol Kand.is, Kampung Tebakang Melayu and Kampung Mongkos. Overall, the outcomes of the research reveal that the active home stay operators were mostly female (61.4%) and most of them aged 46 and above (65.7%) years old. Majority of them participate in home stay program as a part-time basis in order to diversify their income. Majority of them earned monthly gross income below RM2000 (60%) however managed to sustain their home stay business more than 5 years (61.45%)~About 64% of the respondents reported below average (i.e. poor or very poor) with regard to ICT skills and knowledge. Due to very poor skills of using ICT, hence it is not surprising that a majority of the respqndents (84.3%) reported that they do not really use ICT to promote their homestay business. Majority of operators (94.5%) at least completed primary school and this explained that they can be trained to improve their ICT skills and knowledge. All selected villages are under Wireless Network Village Program but most of the participants responded that they did not put internet as important medium of communication in their business due to limitation in accessibility of ICT facilities and supporting services. This explained that most of the operators (91.4%) have no knowledge in blogging, 71.4% did no.t used email to communicate in their daily home stay business and 64.3% did not anticipated in the purpose of using ICT in marketing their home stay. The statistical analysis further revealed that five factors (perceived benefits, ICT knowledge and skills, accessibility to ICT infrastructure, government support and community support) have a strong positive and significant relationship whereby perceived higher cost has a strong negative relationship with home stay operators' decision in ICT adoption in the context of Sarawak. ,The outcomes of this study can benefit policy maker and home stay operators.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":114250541,"openaccessinfo":{"externalids":{"MAG":"2588797441","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The contractile effects of substance P (SP) were studied in isolated rabbit tracheal smooth muscle (TSM) segments in vitro. Noncumulative administration of SP produced dose-dependent increases in TSM tension. The mean (+\/- SE) peak isometric tension (Tmax) with SP was 35.7 (+\/- 6.2%) of the corresponding Tmax response to methacholine. The dose of agonist producing 50% of Tmax (ED50) was significantly lower for SP, averaging 1.8 (+\/- 0.4) X 10(-7) M, vs. 1.7 (+\/- 0.32) X 10(-6) M for methacholine. Blockade of both parasympathetic ganglia with hexamethonium (10(-4) M) and neural transmission with tetrodotoxin (1 microgram\/ml) had no effect on the TSM response to SP. On the other hand, TSM contraction to an ED50 dose of SP was 1) augmented by a mean (+\/- SE) of 470 (+\/- 110%) following pretreatment with the cholinesterase inhibitor, neostigmine (10(-6) M);2) inhibited by a mean (+\/- SE) of 35 (+\/- 15%) with the cholinergic antagonist, atropine (10(-4) M); and 3) also inhibited by a mean (+\/- SE) of 45 (+\/- 11%) following inhibition of acetylcholine synthesis with hemicholinium-3 (10(-4) M). Antagonists to 5-hydroxytryptamine, alpha 1-adrenergic, and histamine receptor binding had no effect on TSM contraction with SP. In contrast, the SP antagonist, D-Pro2,D-Trp7,9-SP, markedly inhibited TSM contraction to SP. Our findings indicate that rabbit TSM is sensitive to SP and its contraction is in part mediated by a peripheral cholinergic action, likely involving the accelerated release of acetylcholine at the airway neuromuscular junction.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25636687,"openaccessinfo":{"externalids":{"MAG":"1941183726","ACL":null,"DOI":"10.1152\/JAPPL.1984.57.5.1551","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Research background: Exchange traded funds (ETFs) are one of the most influential fi-nancial innovations, reshaping the investment funds market in many countries, including Mexico. Due to their similar investment objectives, ETFs are considered substitutes for mutual funds. Purpose of the article: The aim of the article is to provide an in-depth insight into the issues associated with the development of financial markets in Mexico over the period 2002-2012, putting special emphasis on the development patterns of ETFs. Methods: First we use descriptive statistics to unveil basic changes and trends in the Mexican investment funds (ETFs and mutual funds). Then we use a category of the innovation diffusion models, i.e. logistic growth models, in order to explore the key development pat-terns. Data sources and methodological framework are presented in the second section of the article, with a detailed description of the innovation diffusion models applied in the research (based on 3-parametric logistic curve). The sum of assets under management of ETFs and mutual funds is considered as the size of the total investment funds market. Findings & Value added: Empirical findings indicate a significant development of the ETF market, both in terms of assets under management and market share. According to the pre-sented estimations, Mexican ETF market development can be described with the logistic growth models, and three characteristic phases of the logistic curve were clearly observable. The predicted ETF market development patterns point towards a further increase of the market share of ETFs over the next 3-5 years, yet the probability of exceeding the level of ca. 20-30% seems low.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":204414812,"openaccessinfo":{"externalids":{"MAG":"3126097067","ACL":null,"DOI":"10.2139\/ssrn.2749986","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.econstor.eu\/bitstream\/10419\/173330\/1\/wp-gut-fme-a-34-MarszkLechmanKaur.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Self-oscillation is a phenomenon studied across many scientific disciplines, including the engineering of efficient heat engines and electric generators. We investigate the single electron shuttle, a model nano-scale system that exhibits a spontaneous transition towards self-oscillation, from a thermodynamic perspective. We analyse the model at three different levels of description: The fully stochastic level based on Fokker\u2013Planck and Langevin equations, the mean-field (MF) level, and a perturbative solution to the Fokker\u2013Planck equation that works particularly well for small oscillation amplitudes. We provide consistent derivations of the laws of thermodynamics for this model system at each of these levels. At the MF level, an abrupt transition to self-oscillation arises from a Hopf bifurcation of the deterministic equations of motion. At the stochastic level, this transition is smeared out by noise, but vestiges of the bifurcation remain visible in the stationary probability density. At all levels of description, the transition towards self-oscillation is reflected in thermodynamic quantities such as heat flow, work and entropy production rate. Our analysis provides a comprehensive picture of a nano-scale self-oscillating system, with stochastic and deterministic models linked by a unifying thermodynamic perspective.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":119105967,"openaccessinfo":{"externalids":{"MAG":"3102636538","ACL":null,"DOI":"10.1088\/1367-2630\/ab2727","PubMedCentral":null,"ArXiv":"1902.08174"},"license":"CCBY","url":"https:\/\/doi.org\/10.1088\/1367-2630\/ab2727","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper summarizes the autonomous guidance methods (AGMs) for pinpoint soft landing on celestial surfaces. We first review the development of powered descent guidance methods, focusing on their contributions for dealing with constraints and enhancing computational efficiency. With the increasing demand for reusable launchers and more scientific returns from space exploration, pinpoint soft landing has become a basic requirement. Unlike the kilometer-level precision for previous activities, the position accuracy of future planetary landers is within tens of meters of a target respecting all constraints of velocity and attitude, which is a very difficult task and arouses renewed interest in AGMs. This paper states the generalized three- and six-degree-of-freedom optimization problems in the powered descent phase and compares the features of three typical scenarios, i.e., the lunar, Mars, and Earth landing. On this basis, the paper details the characteristics and adaptability of AGMs by comparing aspects of analytical guidance methods, numerical optimization algorithms, and learning-based methods, and discusses the convexification treatment and solution strategies for non-convex problems. Three key issues related to AGM application, including physical feasibility, model accuracy, and real-time performance, are presented afterward for discussion. Many space organizations, such as those in the United States, China, France, Germany, and Japan, have also developed free-flying demonstrators to carry out related research. The guidance methods which have been tested on these demonstrators are briefly introduced at the end of the paper.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":255380851,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1631\/FITEE.1900458","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The clavicle is a doubly-curved long bone which acts as the only osseous strut connecting the trunk to the shoulder and arm (Figure 1). Medially the clavicle articulates with the manubrium of the sternum at the sternoclavicular joint, while laterally it articulates with the acromion of the scapula at the acromioclavicular joint. Trapezius and deltoid muscles attach to the flat outer third, as do the acromioclavicular and coracoclavicular ligaments. The tubular medial third is a boundary of the cervicoaxillary canal, and as such affords protection to the neurovascular bundle supplying the upper limb, including the brachial plexus, subclavian and axillary vessels. The junction between these two different crosssectional configurations occurs in the middle third, which constitutes an area vulnerable to injury.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":36560258,"openaccessinfo":{"externalids":{"MAG":"1971245424","ACL":null,"DOI":"10.12968\/HMED.2007.68.SUP4.23194","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present, still unsatisfactory level of theoretical reflexion in the field of verbal psychotherapy as well as the efforts made for an optimisation of the disturbance- and patient-specific method has led to three positions, which can be considered as developmental trends in verbal psychotherapy: traditional conceptions, endeavours for the extension of the basic behaviour, and integrative concepts. These different viewpoints have been problemised. It is to be hoped that the further development of verbal psychotherapy, owing to a deepened understanding of its modes of action and a further clearing up of the question of indications, will proceed more theoretically founded than it has until now.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31472270,"openaccessinfo":{"externalids":{"MAG":"2413469281","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Exploration of the roots of accumulating environmental degradation has reached to the very foundations of Western civilization. The dominant critiques of these foundations primarily focus on two cosmologies: monism and dualism. The purpose of this paper is to examine these foundations from a Weberian perspective and to offer a little known alternative: immanent dualism. This alternative cosmology suggests that religion could help reorganize late industrial capitalism.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144865996,"openaccessinfo":{"externalids":{"MAG":"2071438009","ACL":null,"DOI":"10.1163\/156853500507843","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the course of development, firms aim to internationalize in order to broaden their influence and enhance their opportunities. There are risks, however, in internationalization. This paper focuses on risks relating to cultural differences, which can affect a firm's reputation when entering foreign markets. The specifics of markets can require perception of socio-cultural differences. A firm's global image must be defined at headquarters, but the communication strategies should be defined by its local offices. Andreas Siegert explains the complexity of the process by which the culture of the country of origin affects worldview and behavioral patterns that can become problematical, or raise risks, in relations between representatives of the two different cultures. The general components of national culture-religion, ethical norms and traditions-evolve slowly within definite parameters. Misunderstandings between culture at headquarters and culture in the country where the branch is located can embrace legal awareness, interpretation of contracts, and perceptions of product quality. The paper uses for a case study Russo-German corporate relations. It reviews aspects of national character in both countries, patterns of negotiation, the perception of details of co-operation, and organizational etiquette. Russia is an important market for German firms, and therefore, consideration of cultural diversity will entail unique business-strategies. The paper uses examples of German employees, recruited only for their skills and experience, that is, neglecting their understanding of Russian norms and traditions, who can fail to communicate well. The paper advances the solution in the creation of an international team aimed to develop a cooperative climate that will transcend distinctive frameworks of existing cultural practices. There is abundant evidence that international teams perform well when identifying problems and seeking out innovative solutions.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":151089886,"openaccessinfo":{"externalids":{"MAG":"9504467","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Tislelizumab, an anti-PD-1 monoclonal antibody, demonstrated efficacy as monotherapy in patients with previously treated PD-L1+ urothelial carcinoma (UC) during a phase 2 study (NCT04004221). Here, gene expression profiles correlating with response and resistance to tislelizumab treatment are reported.Gene expression profiling (GEP) was conducted on baseline tumor samples from 100 Chinese patients with UC enrolled in the phase 2 tislelizumab study using a 1,392-gene panel by HTG EdgeSeq. Gene Signature (GS) scores were calculated using the Gene Set Variation Analysis package. Differential gene expression (DEG) analysis was performed between responders and non-responders using the Wilcoxon test; survival was evaluated using the Cox proportional hazards model and the odds of tumor response for subgroup analysis was estimated by logistic regression.Of patients with available confirmed response results (n=85), DEG analysis found that responders had significantly higher T-cell GS (CD3D, CD3E, CD3G, CD6, SH2D1A, TRAT1) (P=0.04) and MHC I GS (HLA-A, TAP1) (P=0.05), respectively. Using median GS scores as a cutoff, improvement in overall survival (OS) was observed in T-cell\u2013high versus T-cell\u2013low groups (P=0.01) and a trend of longer OS was seen between MHC I\u2013high versus MHC I\u2013low groups. Patients in T-cell and MHC I\u2013double-high subgroups showed further improvement in clinical efficacy (40% objective response rate [ORR], 5.26 month median progression-free survival [PFS], and 15.2 month median OS) than other subgroups (table 1). In addition to immune-related genes in the microenvironment, DEG analysis also revealed that tumor-related genes were highly expressed in non-responders, such as intrinsic genes related to angiogenesis (VEGFA [P=0.07], KDR [P=0.07]), the mTOR pathway (MTOR [P=0.015]), and DNA damage repair (REV3L [P=0.007]). MTOR and REV3L were associated with shorter PFS (P=0.02; P=0.003) and OS (P=0.03; P =0.008), respectively.Abstract 78 Table 1T-cell and MHC I gene signatures associated with clinical efficacy of tislelizumab in patients with UCBy using GEP, T-cell and MHC I GS were identified as potentially predictive biomarkers of response to tislelizumab monotherapy in PD-L1+ UC in this retrospective analysis. By combining these two GS scores, patients with optimal efficacy responses could be identified. Conversely, high expression of tumor intrinsic genes related to angiogenesis and the mTOR pathway may indicate resistance and suggest potential future drug combinations for these patients. Both findings warrant further validation in a phase 3 study (NCT03967977).Editorial assistance was provided by Stephan Lindsey, PhD, and Elizabeth Hermans, PhD (OPEN Health Medical Communications, Chicago. IL), and funded by the study sponsor.CTR20170071","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":230659909,"openaccessinfo":{"externalids":{"MAG":"3111170703","ACL":null,"DOI":"10.1136\/jitc-2020-sitc2020.0078","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"As S-Band frequencies continue to be reallocated for sharing with wireless communications, radar systems are forced to operate in a spectrum that is becoming increasingly congested and contested. Based on other spectrum users, cognitive radar systems must quickly react, change operating frequency, and reconfigure for best performance to share successfully. A real-time impedance tuner is implemented within a software-defined radar (SDRadar) system demonstrated here for maximizing transmitter output power (and transmission range) in real time when changing frequencies to share spectrum. The SDRadar and reconfigurable impedance tuner are shown to achieve up to 46 percent improvement in range, with synchronous reconfiguration accomplished in less than 10 ms. Considering recent and parallel developments in high-power, quickly reconfigurable impedance tuners, it is becoming apparent that power handling, speed, and performance improvements are expected to revolutionize adaptive radar transmission.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":251948179,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/IMS37962.2022.9865597","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To date and worldwide, most business activities in the agribusiness sectors have focused on increasing productive efficiency to the detriment of the environmental impact of these activities, despite close connection that exist between agribusinesses and natural resources. This paper argues that knowledge and innovation management (KIM) can play a key role in fostering and managing creativity in the agribusiness sector. To test this assumption, an empirical model linking KIM with employee creativity, responsible green innovation, and performance in the agribusiness sector of the Dominican Republic is proposed and tested with data from 110 agribusiness companies. We found that strengthening the relationships between the above constructs is needed, with a view to readjusting the meaning of firm performance in the light of emerging (post-pandemic) circumstances for agribusinesses. The statistical analyses yield important implications and recommendations for practice, management, and policy making in these areas in this country and elsewhere.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":252270509,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/bse.3233","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/repositorio.upct.es\/bitstream\/10317\/12244\/1\/management.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In February, March and April starlings fed in a flock on the fields near nestboxes. At night they roosted together in thousands in the reeds of a pool, 5 km from the nestboxes. In February or March each\u2642occupied a particular nestbox. Early in the morning they left the flock, and stayed and sang by the nestboxes for 10-30 min., then returned to the flock but returned soon. The\u2640visited the nestbox a few weeks later. The\u2642had then already started building the nest. Later the\u2640largely completed it. The nests consisted of straw; during the breeding period they were lined with feathers. The\u2642more often brought food to the young than the\u2640. An aphisigraph was used to record the number of feeds brought to the young. To determine the food of the young quantitatively and qualitatively a closely fitting collar of aluminium was placed round their necks for 4 h a day, so that they could not swallow the food. This food was removed from the oesophagus with forceps or from the nest if the young had already rejected it. The food consisted almost entirely of animals. Among 17.933 deliveries there were at least 313 species, among which 267 insect species. Earthworms were only found in minute quantities. Carnivorous arthropods formed 30 % of the food. Although plots with many Tipula larvae were more often visited by the starlings than those with fewer larvae, a colony of starlings had little influence on the population of Tipula paludosa.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":90001418,"openaccessinfo":{"externalids":{"MAG":"2755944521","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article describes a practical technique for permeabilization of higher plant cell walls, which is usually one of the first steps required for immunolocalization of cellular components (and other cytological methods) in plant cell studies. Our strategy involves shattering the walls of cells while the tissues are frozen in liquid nitrogen. It replaces the use of wall degrading enzymes or the need to employ laborious sectioning or other mechanical means for providing access of probes to cells. Freeze\u2010shattering retains the integrity of whole tissues and cells surprisingly well and thus is especially useful when used in conjunction with confocal laser scanning microscopy for recording the three\u2010dimensional arrangement of cytoskeletal elements in relation to cell shape. In this article, we demonstrate the effectiveness of this technique for anti\u2010tubulin and anti\u2010actin immunofluorescence and for rhodamine phalloidin labelling of the cytoskeleton in various higher plant tissues including onion root tip and bulb scale epidermis, Tradescantia stamen hairs and Arabidopsis leaf epidermis and mesophyll cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34914340,"openaccessinfo":{"externalids":{"MAG":"2102617881","ACL":null,"DOI":"10.1046\/j.1365-2818.1977.2390796.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this investigation, a closed-chain kinematic model for two-wheeled vehicles is devised. The kinematic model developed in this work is general and, therefore, it is suitable for describing the complex geometry of the motion of both bicycles and motorcycles. Since the proposed kinematic model is systematically developed in the paper by employing a sound multibody system approach, which is grounded on the use of a straightforward closed-chain kinematic description, it allows for readily evaluating the effectiveness of two alternative methods to formulate the wheel-road contact constraints. The methods employed for this purpose are a technique based on the geometry of the vector cross-product and a strategy based on a simple surface parameterization of the front wheel. To this end, considering a kinematically driven vehicle system, a comparative analysis is performed to analyze the geometry of the contact between the front wheel of the vehicle and the ground, which represents a fundamental problem in the study of the motion of two-wheeled vehicles in general. Subsequently, an exhaustive and extensive numerical analysis, based on the systematic multibody approach mentioned before, is carried out in this work to study the system kinematics in detail. Furthermore, the orientation of the front assembly, which includes the frontal fork, the handlebars, and the front wheel in a seamless subsystem, is implicitly formulated through the definition of three successive rotations, and this approach is used to propose an explicit formulation of its inherent set of Euler angles. In general, the numerical results developed in the present work compare favorably with those found in the literature about vehicle kinematics and contact geometry.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":244612715,"openaccessinfo":{"externalids":{"MAG":"3205933097","ACL":null,"DOI":"10.3390\/machines9110245","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2075-1702\/9\/11\/245\/pdf?version=1634876175","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"This paper addresses one of the main challenges on the way to an offshore transnational multi-terminal dc (MTdc) network: its control and operation. The main objective is to demonstrate the feasibility of using reinforcement learning (RL) techniques to control, in real time, a multi-terminal dc network aimed at integrating offshore wind farms (OWFs). This method of controlling MTdc networks using RL techniques is called Online Distributed Voltage Control (ODVC). The ODVC strategy uses Continuous Action Reinforcement Learning Automata (CARLA) to optimize power flows in real time. To validate the effectiveness of the proposed control method, dynamic simulations are carried out using a MTdc grid model composed of six nodes, interconnecting three offshore wind farms to three European countries. The results obtained demonstrate the advantages of implementing an online distributed voltage control strategy to obtain feasible controlled power flows with low transmission losses. The results obtained demonstrate the feasibility of the proposed method to control, in real time, MTdc networks and that the RL techniques are well-suited for this problem due to their inherent advantages of coping with stochastic environments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7063582,"openaccessinfo":{"externalids":{"MAG":"1490485021","ACL":null,"DOI":"10.1109\/CEC.2015.7257101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg\/m2, range 17.2\u201331.6 kg\/m2): 31 patients (62%) were classified as being overweight or obese (BMI \u2265 23 kg\/m2) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg\/m2). The median follow-up for patients was 31.1 months (range, 6.7\u2013101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30642134,"openaccessinfo":{"externalids":{"MAG":"2344669741","ACL":null,"DOI":"10.3346\/jkms.2016.31.6.886","PubMedCentral":"4853667","ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.3346\/jkms.2016.31.6.886","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Field studies were carried out at the Gubino reclamation facility located at the experimental base of VNIIMZ - a branch of the Federal Research Centre V.V. Dokuchaev Soil Science Institute in 2015-2019. We studied promising high-yielding varieties of legumes - gal?ga orient?lis, cereal rhizome grasses - awnless brome grass, canary grass and highly productive of loose shrub grass of meadow timothy. Studies have established that in the legume-cereal hay stands, the share of the gal?ga orient?lis was 18-83%. The share gal?ga orient?lis variety Gale ranged from 19 to 75%, variety Yubilyar from 18 to 79% and variety Krivich from 25 to 83%. On average, over the years of research, with two-fold mowing, the productivity of the gal?ga orient?lis and its mixtures with cereal grasses was 5.9-8.0 t \/ ha dry weight. The cereal grass mixture with two-cut use provided a dry matter yield at the level of 5.4-7.2 t \/ ha. The highest level of protein nutritional value was noted in the herbage of the gal?ga orient?lis variety Krivich 17-18%. The yield of green mass of legume-cereal hay herbage was 41.5-56.0 t \/ ha. Analysis of the dynamics of the density of the gal?ga orient?lis showed that the most dense was variety Krivich in single-species sowing - up to 166 pcs \/ m2. It was found that among the varieties of the legume component, the tallest, on average, over a five-year study were noted above-ground shoots of the gal?ga orient?lis variety Krivich - up to 117 cm. The gal?ga orient?lis had a high leafiness, the percentage of its leaves was 54-55%. In general, according to the options, the percentage of leaf apparatus in clean crops was 52-56%, in mixed crops - 48-57%. The output of fodder units was 4.7-6.8 thousand \/ ha.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":243093112,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.28983\/asj.y2021i5pp15-20","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/doi.org\/10.28983\/asj.y2021i5pp15-20","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Introduction\/Background Extended field chemoradiation is recommended for patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) metastases. The radiation planning may be based on the positron emission tomography-computed tomography (PET\/CT) while others recommend to rely on a surgical staging. We report the rate of patients for whom the radiation field defined on a PET\/CT basis was modified by the histological PALN status. Methodology Between March 2010 and December 2016, 168 consecutive patients with LACC underwent a pre-therapeutic PET\/CT and PALN dissection. The data were reviewed retrospectively. The diagnostic performance of the PET\/CT for definition of PALN status was calculated. We determined the percentage of patients for whom PALN dissection altered the external beam radiation treatment (EBRT) field defined on the PET\/CT basis. Results Of the 151 patients with negative PALNs on PET\/CT, 26 had histological PALN metastasis. Of the 17 patients with positive PALNs on PET\/CT, 9 were negative on histology. Seven of these 9 false positive cases were located in the common iliac region. Sensitivity, specificity, positive and negative predictive value of PET\/CT were 23.5, 93.3, 47.1 and 82.8% respectively. In total, 35 out of 168 patients underwent EBRT-field adaptation (pelvic vs extended field). The rate of radiation field modification was particularly high (27,7%) in the subgroup of patients with metastatic pelvic lymph nodes (PLNs) on PET\/CT. Conclusion Para-aortic surgical staging contributes significantly to individualize the radiation treatment of patients with LACC, particularly for those with positive PLN at PET\/CT. Indication of surgical staging deserves particular attention when the PET\/CT suggests positive lymph nodes in the common iliac region. Disclosure Nothing to disclose.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":209255649,"openaccessinfo":{"externalids":{"MAG":"2987963592","ACL":null,"DOI":"10.1136\/ijgc-2019-esgo.52","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The failure of a fluid catalysis and cracking unit (FCCU) in a Chinese refinery was investigated by using nondestructive detection methods, fracture surface examination, hardness measurement, chemical composition and corrosion products analysis. The results showed that the failure was caused by the dew point nitrate stress corrosion cracking. For a long operation period, the wall temperature of the regenerator in the FCCU was below the fume dew point. As a result, an acid fume NOx-SOx-H2O medium presented on the surface, resulting in stress corrosion cracking of the component with high residual stress. In order to confirm the relative conclusion, simulated testing was conducted in laboratory, and the results showed similar cracking characteristics. Finally, some suggestions have been made to prevent the stress corrosion cracking of an FCCU from re-occurring in the future.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":139044398,"openaccessinfo":{"externalids":{"MAG":"2467868805","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by protein factors that directly bind specific pre-mRNA sequences. Although much is known about how these splicing factors regulate pre-mRNA splicing events, comparatively little is known about the regulation of the splicing factors themselves. Here, we show that the Drosophila splicing factor P element Somatic Inhibitor (PSI) is phosphorylated at at least two different sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk). These phosphorylation events may be important for regulating protein-protein interactions involving PSI. Additionally, we show that PSI interacts with several proteins in Drosophila S2 tissue culture cells, the majority of which are splicing factors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4684486,"openaccessinfo":{"externalids":{"MAG":"2087750722","ACL":null,"DOI":"10.1371\/journal.pone.0056401","PubMedCentral":"3577899","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0056401&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The pros and cons concerning the involvement of arachidonic acid metabolism in the pathogenesis of psoriasis are presented. The isolation of arachidonic acid metabolites from psoriatic lesions, their extraordinary biological activity, and the therapeutic efficiency in psoriasis of inhibitors of arachidonic acid metabolism all argue in favor of leukotrienes and monohydroxy fatty acids playing an important role in the development of psoriasis plaques. On the other hand, the lack of specificity of the biochemical findings, the failure to reproduce psoriatic lesions by arachidonic acid metabolites, and the therapeutic activity of drugs that have no effect on arachidonic acid metabolism show that the role of arachidonic acid metabolism in the pathogenesis of psoriasis is still controversial. The availability of selective inhibitors of arachidonic acid-metabolizing enzymes for clinical testing is a prerequisite before pathophysiological conclusions can be made, as the present status of knowledge makes any conclusions premature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28300100,"openaccessinfo":{"externalids":{"MAG":"2413156677","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article examines whether the control practices associated with public sector consumerism, such as devolved performance management and accountability, enhance organizations' responsiveness to customer needs and preferences. The research highlighted the need for trade-offs between resource allocation and customer needs and how this affects rationing of services. This is a serious dilemma as the public sector comes under the dual pressures of the consumerist movement and a tightening funding situation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":154903546,"openaccessinfo":{"externalids":{"MAG":"2168366461","ACL":null,"DOI":"10.1080\/09540960902767980","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A new class of organic conductors, mixed valence DIPS Phi 4 polyiodides, have been used as conductive additives in reticulate doping of polymers. Conductive films have been prepared using three modifications of the reticulate doping technique: a standard one-step method (direct casting), a two-step method consisting of swelling the film containing molecularly dispersed DIPS Phi 4 polyiodides, and a recently developed method in which oxidation of molecularly dispersed DIPS Phi 4 and simultaneous crystallization of its polyiodides in situ is induced by treatment of the pristine film containing the donor with I2\/CH2CI2 vapours. The first and the third methods have been found to be the most advantageous. Conductive films with additive concentrations as low as 0.5 wt.% and conductivities of the order of 10-3 S cm-1 were obtained. In all three methods, the best results have been obtained when the conductive network consisted of the most conducting DIPS Phi 4, 2.281 salt.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250812216,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0022-3727\/26\/4\/022","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Cheek mucosa cancer might surround Stensen meatus requiring preservation and relocation of the duct. Sialodochoplasty is necessary to avoid subsequent stricture, cheek swelling, and obstructive sequelae that could make following oncologic follow-up difficult. We report a simple successful technique of parotid duct cannulation and relocation in a 77-year-old woman who underwent cheek mucosa tumor resection for squamous cell carcinoma and free fasciocutaneous forearm reconstruction. Ability of milk clear saliva from the duct orifice after 6 weeks from surgery was assessed clinically, and no fistula or swelling was experienced. Stensen duct cannulation and relocation are a useful adjunctive procedure in the treatment of oral mucosa cancer, preserving salivary gland function while not compromising cancer resection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32686595,"openaccessinfo":{"externalids":{"MAG":"2023187915","ACL":null,"DOI":"10.1097\/SCS.0b013e31824ef809","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To support efficient multimedia retrieval, the multimedia server usually store a large volume of multimedia data in a compressed form, such as in the MPEG format for video and audio data. However, the variable bit rate (VBR) of MPEG movies is a serious problem for a system supporting video-on-demand services (VOD). We propose a smoothing by block adjustment (SBA) scheme to deal with the VBR problem based on the physical storage of multimedia data by a block. If we reduce the frequency of rate adjustment for all movies in a VOD system, we can eliminate much of the useless overhead of the server or network resource adjustment in a VOD system. We show that our SBA scheme can solve VBR problems without incurring much complexity and efficiently reduce frequent rate adjustment for a movie playback.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2013-48":1,"2015-18":1,"unknown":2}},"corpusid":45291042,"openaccessinfo":{"externalids":{"MAG":"2166389801","ACL":null,"DOI":"10.1109\/30.754438","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The protozoan parasite Toxoplasma gondii is a serious cause of fetal mortality in sheep and goats. Oocysts, the parasite stage responsible for initiating infection, are produced following a primary infection in cats. A primary infection in pregnant sheep and goats can establish a placental and fetal infection which may result in fetal death and resorption, abortion or stillbirth. Diagnosis is aided by the clinical picture, the presence of characteristic small white necrotic foci in placental cotyledons, the possible presence of a mummified fetus and on fetal serology and histopathology. Development of the polymerase chain reaction (PCR) specific for T. gondii may also provide a valuable diagnostic tool. Measures to control abortion include improved management of farm cats, fodder and water. Vaccination of sheep with the live vaccine is an effective preventive measure and the use of decoquinate in feed may be useful in some situations. Neospora caninum is related to T. gondii and while its asexual life cycle is similar to that of the latter it is currently not known whether it has a similar sexual life cycle in a definitive host. Neospora is an important cause of fetal loss in cattle and parallels that of T. gondii infection in sheep and goats. While it does not appear to cause frequent losses in these latter animals, experimental infection is readily induced in them and if initiated during pregnancy provides a very good model of the bovine infection. Furthermore clinical signs and pathological lesions in sheep and goats are similar to those induced in them by T. gondii, although there are subtle histopathological differences. These changes will aid possible diagnosis as will specific serological tests such as the indirect immunofluorescent antibody test and the enzyme linked immunosorbent assay and the PCR. Sarcocystis, which exists as numerous species, undergoes a coccidian-like life cycle with each having a distinctive definitive (usually carnivore) host which excretes sporocysts into the environment. Clinical sarcocystiosis is much less commonly diagnosed than toxoplasmosis and neither is it normally associated with fetal infection or abortion in either sheep or goats. However, infection is extremely common throughout the world and follows ingestion of food or water contaminated with sporocysts. Clinical signs, when seen, include fever, anaemia, inappetance and weight loss or reduced weight gain. Central nervous signs (hind limb weakness, ataxia, paresis), acute myopathy and death may occur. Diagnosis is difficult as infection is so common and clinical signs absent, mild or non-specific. Serology may be useful in some situations and histopathology\/immunohistochemistry is valuable for confirming the cause of death. Control relies on preventing contamination of pasture and water with faeces of dogs, foxes and cats or by controlling access of young susceptible stock to contaminated land. Relatively little is known of the immunity induced by infection with Sarcocystis spp. but research indicates that protective immunity does develop and that cell-mediated mechanisms are probably important. It is likely that sarcocystiosis is underdiagnosed as a problem and that better diagnostic methods are needed to show the true extent of the losses caused. Neosporosis on the other hand would appear not to be so common in sheep and goats. The value of experimental infections in these animals may be to provide a comparative model of the infection in cattle in the same way that our understanding of toxoplasmosis in sheep provides a superior model of human toxoplasmosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13747012,"openaccessinfo":{"externalids":{"MAG":"2347121169","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The synchrotron interpretation of radio emission from various astrophysical objects encounters the essential difficulties . These difficulties may be overcome in a new theory of thermal radio emission of non-uniform gas which is based on a stimulated character of thermal radio emission following from the relations between Einstein?s coefficients for spontaneous and induced emission of radiation .","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118258594,"openaccessinfo":{"externalids":{"MAG":"1656203747","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Weak interactions, such as those non-covalent interactions that occur in biological systems, are less well characterised than their strong, covalent counterparts. Here, we discuss associations between two or more molecules and consider the effect of interactions with solvent molecules (particularly water) and changes in the internal structure of the associating molecules on binding. We go on to discuss some of the progress that has been made in the estimation of binding constants.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":5332119,"openaccessinfo":{"externalids":{"MAG":"2952029935","ACL":null,"DOI":"10.1039\/A827057Z","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There is increasing evidence that university students are particularly susceptible to feelings of stress. Given that many post-graduate healthcare students work with patients, the negative outcomes associated with feelings of stress may also impact upon the patient population. This study investigated the prevalence and risk\/ protective factors of self-perceived stress among 43 international public health post-graduate students. Results revealed that almost all participants scored in either the moderate or high stress level category, with South-Asian students scoring particularly high stress scores. Headache frequency, sleep duration and feeling the need for a holiday were the explanatory variables most strongly associated with stress. The results support and add to previous literature which suggests that international students are particularly susceptible to feelings of stress. Suggestions on the management and prevention of stress are proposed, while ideas for future research to build upon this study's findings are considered.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":140937476,"openaccessinfo":{"externalids":{"MAG":"16419496","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Test coverage is sometimes used to measure how thoroughly software is tested and developers and vendors sometimes use it to indicate their confidence in the readiness of their software. This survey studies and compares 17 coverage-based testing tools primarily focusing on, but not restricted to, coverage measurement. We also survey features such as program prioritization for testing, assistance in debugging, automatic generation of test cases and customization of test reports. Such features make tools more useful and practical, especially for large-scale, commercial software applications. Our initial motivations were both to understand the available test coverage tools and to compare them to a tool that we have developed, called eXVantage (a tool suite that includes code coverage testing, debugging, performance profiling and reporting). Our study shows that each tool has some unique features tailored to its application domains. The readers may use this study to help pick the right coverage testing tools for their needs and environment. This paper is also valuable to those who are new to the practice and the art of software coverage testing, as well as those who want to understand the gap between industry and academia.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":29943875,"openaccessinfo":{"externalids":{"MAG":"2151099659","ACL":null,"DOI":"10.1093\/comjnl\/bxm021","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of this article is to analyze the level of association and effect between work alienation, deviant workplace behavior, and performance in public sector organizations. Based on a literature review and relying on the theoretical perspective of the knowledge-based view strategy, the hypotheses were formulated. The method consisted of a cross-sectional study in Mexican public organizations, and a multivariate analysis of structural equation modeling (SEM) was performed. The results confirmed the association between work alienation, deviant workplace behavior, and performance. Furthermore, findings showed a high and positive relationship between work alienation and organizational performance within the context. The originality lies in the positive incidence among the variables under study within the public sector context; this is not consistent with what is suggested by the related literature.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":251829158,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/su141710490","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2071-1050\/14\/17\/10490\/pdf?version=1661254562","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"IN 1963 we were confronted with a complication of ascaris infestation necessitating biliary tract surgery. The case was considered an interesting oddity. However, the same problem was thrust upon us again in 1966. We realize now that surgical complications ofAscaris lumbricoidesare not rare and must play a respectable role in surgical diagnosis. Reference to this problem is infrequent in American surgical literature. This paper will review the epidemiology and surgical implications of the ascaris, and will explore in depth the problem of biliary ascariasis. Epidemiology Ascaris lumbricoides, world wide in distribution, is the most common parasite to infest man who is the only susceptible host.1-5 The significant area of endemia in the United States is the southeast where the infestation rate may be 50%.1,3,6While children are the most frequent victims, adults are not spared and both urban and rural populations may play host to","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":33152721,"openaccessinfo":{"externalids":{"MAG":"1966616418","ACL":null,"DOI":"10.1001\/ARCHSURG.1968.01340040091018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Protease-activated receptor 1 (PAR1) belongs to a unique family of G protein-coupled receptors that carry their own tethered ligand at the extracellular domain. Upon proteolytic cleavage, the ligand is exposed and is allowed to intramolecularly self-activate, triggering a cascade of signaling events leading to changes in cell shape, proliferation, migration, secretion, adhesion, and gene transcription. PAR1 is identified as an oncogene, and its expression is implicated in the development and metastasis of cancers of the breast, ovary, prostate, lung, pancreas, colon, and skin. The level of PAR1 expression correlates directly with the degree of invasiveness in primary breast tissue and established cancer cell lines. Most notably, PAR1 expression alone is sufficient in increasing migration, invasion, and tumor formation in the PAR1-null, minimally invasive MCF-7 breast cancer cell line. Conversely, silencing of PAR1 expression in the PAR1-positive, highly invasive MDA-MB-231 breast cancer cell line decreases migration and invasion. Here we investigate the potential of PAR1 as a target for cancer chemotherapy, using a powerful pepducin-based technology as a PAR1 inhibitor. Pepducins are palmitoylated cell-penetrating peptides that act as intracellular inhibitors of PAR1-G protein signal transference. We observe that pepducin therapy decreases cell proliferation and increases apoptosis in MDA-MB-231 cells and suppresses tumor growth in a xenograft model in which MDA-MB-231 cells are injected into the mammary fat pads of athymic nude mice. The use of two or more chemotherapy drugs in combination is thought to offer a superior tumor response and is commonly practiced in cancer therapy. To investigate the effects of PAR1 inhibition in the context of combination therapy, pepducins were administered together with docetaxel, a microtubule-stabilizing chemotherapy drug used commonly in breast cancer treatment. Concomitant administration of pepducin and docetaxel showed significantly enhanced tumor growth suppression in the xenograft model. In fact, when pepducin and docetaxel were administered together at doses that are individually ineffective, tumor development from MDA-MB-231 cells was almost completely abrogated. These results were supported by the MTT cell proliferation assay in which quantitative data analysis by the isobologram method revealed a highly synergistic interaction between pepducin and docetaxel. Put together, these in vitro and xenograft data suggest that therapeutics that block PAR1 signaling are beneficial in suppressing tumor development and support the potential of PAR1 as a viable target in cancer chemotherapy. Our current work involves the elucidation of the PAR1 signaling pathway and combination therapy synergy mechanism.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":75912200,"openaccessinfo":{"externalids":{"MAG":"2346862222","ACL":null,"DOI":"10.1136\/jim-55-02-97","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A novel internal triple-band planar inverted-F antenna (PIFA) for operating at Personal Communication Services\/International Mobile Telecommunications (PCS\/IMT)-2000\/Bluetooth bands is proposed. The proposed antenna can be reduced in size by using a radiating element with thickness and a via hole. A broadband characteristic is obtained by optimizing the thickness of the radiating patch and the offset gap between patch and ground. Dual resonant frequencies are obtained by optimizing the slit lengths and the location of the via hole. The proposed antenna is well suited as an internal antenna due to its small size and wide bandwidth, of about 42%, which covers the PCS (1.75-1.87 GHz), IMT-2000 (1.92-2.17 GHz) and Bluetooth (2.402-2.48 GHz) bands. The design of the proposed antenna and experimental results are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15934221,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/lawp.2004.824170","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Research to identify the role of primary care in cancer care is important. However, trials in primary care are difficult.To understand how patients, families, and primary care clinicians view their role in cancer care and identify opportunities for cancer primary care research.Qualitative study embedded within a feasibility cluster randomised controlled trial of a primary care based needs assessment intervention. The Supportive Cancer Needs Survey (SCNS) was the main outcome. In-depth interviews with patients\/carers and focus groups with primary care staff explored views on cancer care and trial participation. Data were recorded, transcribed verbatim, and analysed thematically by three independent researchers.Fifteen cancer patients and three carers were interviewed and four focus groups (n = 11) were conducted. Three themes were generated satisfaction with current care; key time-points for improved cancer care; and information and research. Satisfaction with current care among patients was high in spite of 72% reporting at least one moderate-high unmet need at baseline. Most patients undergoing cancer treatment were unsure when to access primary care. Patients and carers highly valued proactive contact from their practice following diagnosis though this was uncommon. Post-oncology discharge was a key time-point for information needs and support for patients. Patients were reluctant to consider palliative care in spite of palliative care needs. Some felt therapeutic benefit from completing study measures.Patients are satisfied with cancer primary care despite unmet needs. Palliative care is poorly understood by many who may benefit. Research participation may benefit some patients.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204065204,"openaccessinfo":{"externalids":{"MAG":"2977162858","ACL":null,"DOI":"10.3399\/bjgp19x703505","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/bjgp.org\/content\/69\/suppl_1.cover.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Accelerometer mounting fixtures were prepared with the different materials(Ti and SUS). The dynamic characteristics of the mounting fixture were analyzed by finite element method(FEM), and the mode shape of each order and the displacement response for modelling the mounting fixture were analyzed by ANSYS, then resonant frequencies of the mounting fixtures with Ti and SUS were 22.700 and 23.390 kHz, respectively. The dynamic characteristics of the mounting fixture with the different positions were obtained by using laser interferometer. The response of the accelerometer was nearly a constant from 40 Hz to 500 Hz, but the change of the acceleration was increased with an increase of the frequency above 500 Hz.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108145674,"openaccessinfo":{"externalids":{"MAG":"224706656","ACL":null,"DOI":"10.5050\/KSNVN.2007.17.4.350","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The current pandemic situation has created havoc in the regular workings of many 15 institutions such as those dedicated to teaching and, therefore, the urge for alternatives to 16 traditional face to face teaching has raised. However, for certain subjects, such as the Earth 17 Sciences, distance teaching approaches could be seen as counterintuitive to the essential 18 foundations of the subject (where empirical information, especially from fieldwork, was 19 paramount for its foundation and growth). We consider in this work remote operations, which 20 could complement, improve and perhaps even replace the traditional approach for Earth Sciences 21 teaching, potentially producing better learning outcomes, even in relation to laboratory and 22 fieldwork, including work concerning studies in locations out of planet Earth. Additionally, we 23 consider the possible advantages for other professional settings related to this area, such as those 24 concerning terrain characterization for Engineering works, mineral resources and environmental 25 studies, as well as possible support for space missions and stations in other astronomical bodies 26 (where mineral exploration and extraction could be developed and, hence, especially benefit from 27 remote operations). 28","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231184372,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The deployment of point-to-point WDM systems has just begun in core networks to accommodate the explosive growth in bandwidth demands of Internet traffic and data communications. Now that the basic technologies for wavelength division multiplexing and optical amplifiers have been established, wavelength path management is the key to full exploitation of the advantages of meshed photonic networks by improving the reliability and efficiency of networks. After describing the photonic network layer model, this paper describes photonic network management architecture and a flexible optical path management. Then, a new distributed restoration technique and a spare capacity design method are proposed. The applicability of the proposed technique is discussed based on the results of prototyping of an optical crossconnect management system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":46592979,"openaccessinfo":{"externalids":{"MAG":"2473072178","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The aim of the present study is to investigate how the consumption of geek products acts in the identity of individuals who see themselves as members of this urban tribe. Geeks are taken as committed members fascinated by topics related to fantasy and science fiction universes; if we take into account a micro-scale, they form an identity territory. Based on its theoretical approach, the goal of the current research lies on promoting a dialogue between studies that have adopted the consumer culture theory (CCT) and organizational identity research, by taking into consideration that urban tribes are a kind of organization. The research corpus comprised interviews with seventeen people who identify themselves as geeks; these interviews were analyzed based on thematic categorization. Based on then results, geek-products' consumption starts at childhood and goes all the way to adulthood; this process is influenced by characters in the fantasy and fiction universes. The consumed products hold symbolic elements of fantasy and fiction, so that they end up representing the extension of this tribe's members 'self'; moreover, they are a way of building collective identities within an urban tribe, in this case, geeks. We have shown that organizational identity studies can lead to greater dialogue with CCT in order to better understand complexities added to identity and multiple affiliations, and links in the identity construction of people forming an organization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248018634,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1590\/1984-92302022v29n0003en","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.scielo.br\/j\/osoc\/a\/FfbSKZ7pFZpkLSycmj3c6St\/?lang=en&format=pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Context: Macular edema (ME) is a common pathologic condition causing vision impairment. Diabetic retinopathy is a common cause of ME which can also develop after cataract surgery. Optical coherence tomography (OCT) is a noninvasive diagnostic technique that provides imaging of fine retinal details. Proper diagnosis of the underlying etiology shall affect the management. Aims: This study aims to differentiation between diabetic and pseudophakic ME (DME and PME) using OCT. Settings and Design: Cross-sectional study of 2 Groups; A: 30 eyes with DME and B: 20 eyes with PME. Subjects and Methods: Full clinical evaluation, OCT scanning, and data analysis were done for both groups. Statistical Analysis Used: SPSS software v. 16 was used for: Descriptive statistics, mean, range, and standard deviation. Student's t-test was used for comparison between means. Pearson correlation coefficient was used to assess correlation between variables. Results: Maximum macular thickness and central macular thickness were elevated in both groups but were higher in PME group (P = 0.042 and P = 0.00001, respectively). Macular thickness\/volume ratio (TVR) was higher in PME group (P = 0.00001). Cystic changes had different distribution patterns; ganglion cell layer and retinal nerve fiber layer layers were free in PME(Pseudophakic macular edema) while inner nuclear layer and outer nuclear layer were affected in both groups (P = 0.0061). Epiretinal membranes were found much more in DME group (P = 0.0452). Dome-shaped macula was frequently noticed in PME group (P = 0.043). Conclusions: PME and DME have different OCT features; higher TVR, dome-shaped macula, absence of ERM suggest PME while lower TVR, presence of inner retinal cysts and\/or ERM suggest DME.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":246382188,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4103\/erj.erj_4_21","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The morbidity and mortality conference (MMC) offers an opportunity to incorporate principles of quality improvement and patient safety, with the potential to improve patient outcomes, while providing a rich opportunity to teach. However, the format of the conference varies tremendously among academic programs, and the goals of the conference are often not clearly defined. The cases presented also vary tremendously. The goal was to move the MMC at our institution beyond an autopsy and clinical case review to a comprehensive model aimed at improving the quality and safety of care provided and improving of the quality of education at an academic medical institution. The conference is a core requirement of the neonatal-perinatal medicine fellows' education at our institution. Previously there was passive learner involvement. We implemented structured changes to the process of case selection, preparation and presentation utilizing patient selection guidelines, an adapted worksheet for critically analyzing the case and a PowerPoint presentation template which includes a clear outline with objectives. This has resulted in uniformity in the format and content of our MMC and has created a vehicle for identifying areas of weaknesses in our practice and system leading to quality improvement initiative projects aimed at improving the quality and safety of the care delivered to our patients. This paper details the evolution process of the MMC at our academic institution and describes the structured changes implemented, their impact and lessons learned.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":211535169,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4314\/jcm.v22i2.16","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The aim was to assess the shear bond strength (SBS) of lithium disilicate (LD) ceramic to resin composite with different universal adhesives, duration of ageing and silane. One hundred and twenty LD ceramic discs were processed, fired and etched (HF acid 5%) for 20 s (sec). All specimens were divided into 12 groups (n = 10), based on different combinations of, 3 different universal adhesives [Scotchbond (SB) Universal Adhesive, All-Bond (AB) Universal, and Futurabond U (FU)], silane and different duration of ageing [24 h and 3 months]. Composite resin cylinders (Tetric ceram) (3mm \u00d7 2 mm) were formed using bonding jig on ceramic and were light-cured. The specimens in groups 1\u20136 and 7\u201312 were stored in distilled water (37 \u00b0C) for 24 h and 3 months (thermocycling -5000 cycles 5\u201355 \u00b0C\/30 s dwell time) before being subjected to bond strength testing respectively. Using universal testing machine shear bond test was performed at a crosshead speed of 1 mm\/min. Failure modes and fracture patterns were assessed using stereomicroscope and scanning electron microscope. Analysis of variance was performed to analyze data. SBS was significantly higher with silane than without silane (p < 0.01), regardless of the type of adhesive or storage duration. Specimens tested at 24 h storage showed significantly higher (p < 0.01) SBS than specimens tested after 3-months. A comparison among different universal adhesives showed significantly distinct bond strength (p < 0.01). Optimal bonds to LD were achieved by application of silane. While ageing through storage had a negative impact on the SBS, it varied among different adhesives.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":139335059,"openaccessinfo":{"externalids":{"MAG":"2755282080","ACL":null,"DOI":"10.1080\/01694243.2017.1372932","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Recently there has been much concern regarding the use of forest resources in Australia. Proposals have been made to governments that would safeguard the forest environment but add to the costs of forest and logging industries. An analysis of the short-run effects of such proposals using the ORANI general equilibrium model suggests that downstream wood-using industries and the economy in general would suffer small declines in output but that activity and employment in the forest and logging industry itself may increase.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":153451683,"openaccessinfo":{"externalids":{"MAG":"1567240277","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper discusses the results of theoretical and experimental investigation of magnetohydrodynamic generator with liquid metal working body. This electric machine is used to convert mechanical energy, supplied by thermoacoustic engine, to an AC form of electrical energy. The purpose of this technology is an electricity production in deep Space, potentially suitable for long term missions far away from Sun.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":231617587,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/RTUCON51174.2020.9316584","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider a two-stage electricity market comprising a forward and a realtime settlement. The former pre-dispatches the power system following a least-cost merit order and facing an uncertain net demand, while the latter copes with the plausible deviations with respect to the forward schedule by making use of power regulation during the actual operation of the system. Standard industry practice deals with the uncertain net demand in the forward stage by replacing it with a good estimate of its conditional expectation (usually referred to as a point forecast), so as to minimize the need for power regulation in real time. However, it is well known that the cost structure of a power system is highly asymmetric and dependent on its operating point, with the result that minimizing the amount of power imbalances is not necessarily aligned with minimizing operating costs. In this paper, we propose a mixed-integer program to construct, from the available historical data, an alternative estimate of the net demand that accounts for the power system's cost asymmetry. Furthermore, to accommodate the strong dependence of \u2217Corresponding author Email addresses: email@example.com (J. M. Morales), email@example.com (M. A. Mu\u00f1oz), email@example.com (S. Pineda) Preprint submitted to Elsevier March 22, 2022 this cost on the power system's operating point, we use clustering to tailor the proposed estimate to the foreseen net-demand regime. By way of an illustrative example and a more realistic case study based on the European power system, we show that our approach leads to substantial cost savings compared to the customary way of doing.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":247595398,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"What selects azeotropic pairs and governs the azeotropic conditions (composition and temperature) is an open and intriguing question. A combined simulation and experimental work presented here investigates this by considering ethanol-water mixtures. We find identical distributions of center-of-mass diffusion coefficients for ethanol and water molecules under the azeotropic condition (95.5 wt % ethanol +4.5 wt % water, Tazeo = 351.1K). Moreover, the particle displacements show strong interspecies correlations at Tazeo. Interestingly, simulated reorientation time distributions become identical at Tazeo but at a composition different from that at which the translational diffusion distributions overlapped. Cluster analyses indicate that solutions at Tazeo with xwater \u2264 15 wt % are more microheterogeneous than those with higher water content, although no anomaly in the composition-dependent solution structural properties was detected. Ethanol-water and ethanol-ethanol interaction energies show pronounced nonideal composition dependence, but the size of the relative fluctuations in them remained small (\u223c0.5kBT). Rare water-water H-bonding, predominant water-ethanol H-bonding, and a sizable population of \"free\" water molecules characterize the azeotropic solutions. The red edge excitation spectroscopic (REES) measurements with a dissolved anionic fluorescent dye, coumarin343 (C343), support the predicted solution microheterogeneity by showing a nonmonotonic composition dependence of the excitation energy-induced changes in the fluorescence emission spectral frequencies and bandwidths, the largest changes being under the azeotropic condition. Subsequent dynamic anisotropy measurements reveal a nonmonotonic composition dependence of C343 rotation times with a peak under the azeotropic condition. In summary, equalization of the component translational diffusion coefficients and solution microheterogeneity with regular composition dependence of the solution structure appear to characterize the ethanol-water azeotrope.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262125815,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acs.jpcb.3c02486","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of the paper is presentation of the prevalence of infections of the Salmonella strains in the Lublin voivodeship in the years 1980-2000 in comparison with their nationwide prevalence in the same period. The analysed material comprised epidemiological data concerning the incidence rates of salmonelloses registered in Poland in the studied period. Since the beginning of the 1980s there was observed a constantly increasing trend in incidence rates of salmonelloses. After 1988 throughout Poland and after 1990 in the Lublin voivodeship there was noted gradual decline in incidence of infections caused by Salmonellas. Administrative decisions and recent improvements in sanitary situation in our country caused appearance of that favourable, decreasing trend of incidence rates of salmonelloses. The statistics concerning extraintestinal infections with Salmonellas are still unreliable, especially in the Lublin voivodeship.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19790439,"openaccessinfo":{"externalids":{"MAG":"2412428352","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gonzalez develops an innovative model that considers different management stages of mutual fund companies, overcoming the traditional dispute between the different approaches used in banking and insurance research.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":168639685,"openaccessinfo":{"externalids":{"MAG":"2763067178","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":". We report the first demonstration of the 1D quantized conductance at around 80 K on !nAs\/(AIGa)Sb split gate devices fabricated by using electron beam lithography and wet chemical etching. Nonlinear transport properties measured between 4.2 K and 115 K are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250978359,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mutations in SLC4A1, encoding the chloride-bicarbonate exchanger AE1, cause distal renal tubular acidosis (dRTA), a disease of defective urinary acidification by the distal nephron. In this study we report a novel missense mutation, G609R, causing dominant dRTA in affected members of a large Caucasian pedigree who all exhibited metabolic acidosis with alkaline urine, prominent nephrocalcinosis, and progressive renal impairment. To investigate the potential disease mechanism, the consequent effects of this mutation were determined. We first assessed anion transport function of G609R by expression in Xenopus oocytes. Western blotting and immunofluorescence demonstrated that the mutant protein was expressed at the oocyte cell surface. Measuring chloride and bicarbonate fluxes revealed normal 4,4\u2032-diisothiocyanostilbene-2,2\u2032-disulfonic acid-inhibitable anion exchange, suggesting that loss-of-function of kAE1 cannot explain the severe disease phenotype in this kindred. We next expressed epitope-tagged wild-type or mutant kAE1 in Madin-Darby canine kidney cells. In monolayers grown to polarity, mutant kAE1 was detected subapically and at the apical membrane, as well as at the basolateral membrane, in contrast to the normal basolateral appearance of wild-type kAE1. These findings suggest that the seventh transmembrane domain that contains Gly-609 plays an important role in targeting kAE1 to the correct cell surface compartment. They confirm that dominant dRTA is associated with non-polarized trafficking of the protein, with no significant effect on anion transport function in vitro, which remains an unusual mechanism of human disease.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":25420614,"openaccessinfo":{"externalids":{"MAG":"2074492703","ACL":null,"DOI":"10.1074\/JBC.M400188200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"TPS446 Background: Neoadjuvant treatment for potentially curable pancreatic cancer (PDAC) is increasing in acceptability, but a standard regimen has yet to be established. Multiple studies have demonstrated feasibility and effectiveness of the FOLFIRINOX (5-fluorouracil, leucovorin, oxaliplatin and irinotecan) regimen in the perioperative setting. However, FOLFIRINOX often requires dose modifications, delays and growth factor support due to excessive toxicity which can complicate care delivery when given neoadjuvantly. Liposomal irinotecan injection (Nal-IRI) is FDA approved with a well-tolerated safety profile in relapsed, refractory metastatic PDAC. The current study aims to substitute Nal-IRI for traditional irinotecan in the standard FOLFIRINOX regimen (NALIRIFOX) and to demonstrate safe and effective neoadjuvant delivery. Methods: This phase II, open-label, multicenter single-arm study focuses on patients (pts) with operable PDAC without metastatic disease. Other key eligibility criteria include age \u226518 years, resectability confirmed by multiD GI tumor board (resectable vs. borderline), adequate cardiac, renal, hepatic function and ECOG performance status of 0 to 1. Pts receive NALIRIFOX regimen as per the table below every 2 weeks for four months followed by disease reassessment. Pts who remain surgical candidates will undergo surgical resection within 4 to 8 weeks following last dose of therapy. The primary endpoint is to assess safety and feasibility of regimen in perioperative setting. Secondary endpoints include R0 resection rate, clinical, biochemical and radiological response rate and patient-reported quality of life during treatment as measured by the NCI validated FACT-G scale. Enrollment continues to a maximum of 28 evaluable pts to demonstrate a reduction in historical 30 day postoperative complication rate. Clinical trial information: NCT03483038. [Table: see text]","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234166370,"openaccessinfo":{"externalids":{"MAG":"3121624082","ACL":null,"DOI":"10.1200\/JCO.2021.39.3_SUPPL.TPS446","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mesomeric divalent 1,1'-(3-oxapentamethylene)-bridged bis(indenyl)lanthanidocenes, meso-[O(CH2CH2C9H6)2]Ln\u00b7(DME) (Ln = Sm (2),Yb (3)), have been synthesized by reduction of a mixture of rac\/meso-[O(CH2CH2C9H6)2]LnCl\u00b7THF (Ln = Sm, Yb) with Na or reaction of LnI2 (Ln = Sm, Yb) with [O(CH2CH2C9H6K)2] in THF followed by recrystallization in DME. The structures of these meso, ansa-lanthanidocenes were determined by X-ray diffraction analysis. The factors that dictated the rac\/meso selectivity are discussed. Nonbridged divalent lanthanide complexes (CH3OCH2CH2C9H6)2LnII (Ln = Sm (4), Yb (5)) were also synthesized for comparison by the reaction of LnI2 (Ln = Sm, Yb) with (CH3OCH2CH2C9H6)2K in THF. Stereoselective polymerization of methyl methacrylate with these divalent lanthanide complexes as single-component catalysts was preliminarily investigated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":96782861,"openaccessinfo":{"externalids":{"MAG":"2080291981","ACL":null,"DOI":"10.1021\/OM049753A","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of this paper is twofold: first, to determine the immigrants' ethnic identity, i.e. the degree of identification to the culture and society of the country of origin and the host country and second, to investigate the impact of ethnic identity on the immigrants' employment outcomes. Using rich survey data from France and relying on a polychoric principal component analysis, this paper proposes two richer measures of ethnic identity than the ones used in the literature, namely: i) the degree of commitment to the origin country culture and ii) the extent to which the individual holds multiple identities. The paper investigates the impact of the ethnic identity measures on the employment outcomes of immigrants in France. The results show that having multiple identities improves the employment outcomes of the migrants and contribute to help design effective post-immigration policies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":197636488,"openaccessinfo":{"externalids":{"MAG":"2949596683","ACL":null,"DOI":"10.2139\/ssrn.3422232","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.cesifo.org\/DocDL\/cesifo1_wp7651.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Robot automation systems are rapidly taking the place of the human work force. One of the benefits is that this change provides the human work force with the time to spend on more creative tasks. The highest population of robots is in spot welding, spray painting, material handling, and arc welding. Spot welding and spray painting applications are mostly in the automotive industry. However, arc welding and material handling have applications in a broad range of industries, such as, automotive sub-suppliers, furniture manufacturers, and agricultural machine manufacturers. The number of arc welding automation robot stations is growing very rapidly. The two most common stations are the GMAW (Gas Metal Arc Welding) station and the GTAW (Gas Tungsten Arc Welding) station. These two stations are the most common because they are so well suited to robot systems. Typically, a robot arc welding station is comprised of a robot, a robot controller, arc welding equipment, a work clamp and motion devices to hold work pieces accurately in position (considering heat deformation), robot motion devices to move around the robot for a larger working range and better weld positions, sensors, and safety devices. A typical arc welding robot station is illustrated in Figure 1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16342393,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Ethnography, with its focus on everyday experience, can yield significant insights into understanding migrant mental health in contexts where signs of severe mental distress remain largely imperceptible, and more generally, into how stresses and strains are lived through the spaces, times and affective atmospheres of the city. Migrant ethnography can help us reconsider the oft-made connection between everyday stress and mental ill health. In this contribution, drawing on field evidence in central and peripheral Shanghai, we highlight the importance of attending to the forms of spatial and temporal agency through which migrants actively manage the ways in which the city affects their subjectivity. These everyday subjective practices serve to problematize the very concept of 'mental health'. The paper engages in a critical dialogue with sociological and epidemiological research that assesses migrant mental health states through the lens of the vulnerability or resilience of this social group, often reducing citiness to a series of environmental 'stressors'. Distinct from methods ascertaining or arguing against the prevalence of mental disorders among urban migrants, the insight of urban ethnography is to open up a space to explore the mediations that operate dialogically between the city as lived by migrants through particular places and situations and forms of distress.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":171092666,"openaccessinfo":{"externalids":{"MAG":"2945960235","ACL":null,"DOI":"10.1093\/inthealth\/ihz029","PubMedCentral":"6822685","ArXiv":null},"license":"CCBY","url":"https:\/\/academic.oup.com\/inthealth\/article-pdf\/11\/Supplement_1\/S7\/30338868\/ihz029.pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"The Lotus Sutra as a text has been translated into different languages. In the English language several versions of the Lotus Sutra exist today. As a Buddhist text, its English translations have a wider outreach reaching the Occidental beyond its Oriental origin. Based on Kumarajiva's translation of the Lotus Sutra, the English translations are reputed to have kept to its appeal and richness of its language. This paper looks at the discourse of the Parable of the Medicinal Herbs from the 2009 translation by Burton Watson. The corpus consists of the 216 lines of the verse format of the parable. A discourse analysis of the text revealed the extensive use of literary devices and binomials to deliver its teachings and the message of impartiality. It is through these language features that makes it linguistically appealing to its readers. I wish to caveat that this attempt to examine this rich and classical text is with the humble understanding that it will not lend itself to any single interpretation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56057104,"openaccessinfo":{"externalids":{"MAG":"2237548878","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Systemic immunoglobulin light chain (AL) amyloidosis is a disorder characterized by the production of clonal serum free light chains that misfold, aggregate, and deposit in vital organs. Treatment of this disease is typically targeted at the abnormal plasma cell clone in the bone marrow which is the source of the amyloidogenic light chain. First-line therapies in this disease are well established, but in the relapsed or refractory setting, there are many treatment options, including immunomodulatory agents, proteasome inhibitors, alkylating agents, and monoclonal antibodies. Decisions regarding treatment choice should be made by a multidisciplinary team with consideration of the patient's functional status, disease stage, degree of organ dysfunction, and potential treatment toxicities. Herein we review the current treatment options available for patients with relapsed or refractory AL amyloidosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":204871398,"openaccessinfo":{"externalids":{"MAG":"2981450373","ACL":null,"DOI":"10.2147\/JBM.S183857","PubMedCentral":"6815750","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cathepsins are lysosomal proteases that are distributed in many normal tissues and are primarily responsible for intracellular catabolism and turnover. The increased level of cathepsins in tumors together with their ability to degrade extracellular matrix proteins has led to the hypothesis that they are involved in the process of invasion and metastasis. We studied immunohistochemically the expression of cathepsins B, pro-D and pro-L in 8 cases of dermatofibrosarcoma protuberans (DFS), five cases of atypical fibroxanthoma (AFX) and twenty cases of dermatofibroma (DF). Expression of cathepsins B and pro-D could be detected in 5 of the 8 cases (62.5%) of DFS, whereas cathepsin pro-L was found in 4 (50%) cases. All AFX expressed cathepsin pro-L, whereas cathepsins B and pro-D were observed in 4 out of 5 cases. None of the malignant tumors showed a recurrence or metastasis after a period of four years. We found no expression of cathepsins in DF. In the epidermis and appendages, an expression of cathepsins pro-D, pro-L and B was seen. We conclude that cathepsins may be markers of increased metabolism rather than specific markers of malignancy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27610430,"openaccessinfo":{"externalids":{"MAG":"1538433470","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the presence of fluoroglucose, an inhibitor of formation of mannosylphosphoryl and glucosylphosphoryl-dolichol, lipid-dependent glycosylation of influenza virus glycoproteins is strongly, but not completely inhibited. The oligosaccharides that were transferred to protein in the presence of fluoroglucose came directly dolichol-linked intermediates. However, they were smaller than the normal high-mannose oligosaccharides and, furthermore, resistant towards digestion with endo-beta-N-acetylglucosaminidase H. By excluding mannosylphosphoryl-dolichol, similar dolichyl-pyrophosphate-liked intermediates were synthesized in vitro by membranes from fluoroglucose-treated cells and they were shown to glycosylate protein.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31939600,"openaccessinfo":{"externalids":{"MAG":"2044426097","ACL":null,"DOI":"10.1111\/J.1432-1033.1980.TB04875.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have confirmed the existence of a new Cu-Al-Se phase grown by molecular beam epitaxy. The phase possesses a crystal structure equivalent to the tetragonal structure compound Cu5FeS4 found in the Cu-Fe-S system, and has a direct band gap of around 3.1 eV at room temperature. The new Cu-Al-Se phase clearly differs from the chalcopyrite structure compound CuAlSe2, and is considered to be a Cu5AlSe4 compound.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250752560,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1143\/JJAP.31.2407","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The behavior of magnesium in the desulfurization process of molten iron with magnesium vapor produced in-situ by the aluminothermic reduction of magnesium oxide has been investigated. The magnesium concentration first increased rapidly, reaching the maximum, and then decreased gradually to a very low level. The magnesium concentration of the molten iron was mainly that of the dissolved magnesium and the following decrease in the magnesium concentration was due to the evaporation from the melt surface and the mass transfer of the dissolved magnesium to the bubble surface. Under the present experimental conditions, the magnesium concentration increased with increasing temperature, pellet mass, carrier gas flow rate and decreasing initial sulfur concentration. Decreasing the pellet mass and increasing initial sulfur concentration made the desulfurization efficiency higher and decreased the amounts of magnesium dissolving into the melt and leaving the melt. The equilibrium relation between [ppmMg] and [ppmS] did not conflict with the present experimental results at temperatures from 1 553 to 1 673 K. A mathematical model for analyzing the behavior of magnesium in the present desulfurization process has been developed. The calculated magnesium and sulfur concentrations are well consistent with the experimental results. The calculated results demonstrate that the existence of the peak of magnesium concentration is reasonable. The present mathematical model can also explain the effects of pellet mass and initial sulfur concentration on the behavior of magnesium injected into the melt.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":92854341,"openaccessinfo":{"externalids":{"MAG":"406974842","ACL":null,"DOI":"10.2355\/ISIJINTERNATIONAL.42.685","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We measure the effective nonlinearity of various hollow-core photonic band-gap fibers. Our findings indicate that differences of tens of nanometers in the fiber structure result in significant changes to the power propagating in the silica glass and thus in the effective nonlinearity of the fiber. These results show that it is possible to engineer the nonlinear response of these fibers via small changes to the glass structure.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2015-18":1,"unknown":2}},"corpusid":39937103,"openaccessinfo":{"externalids":{"MAG":"2131207511","ACL":null,"DOI":"10.1364\/OE.15.003507","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A flat-histogram Monte Carlo sampling method is used to calculate the free-energy landscape of a simple semi-flexible triangulated membrane model as a function of the number of vertices and the number of free edges. Results yield the equilibrium ratio of open (disk) and closed (vesicle) states, the free-energy barrier between these states, and the scaling of vesicle free energy with size N in the range from 6 to 200 vertices. Deviations from the predictions of a simple model for the disk-vesicle transition are found to result from the fluctuations of the edge. Vesicle free energies are fit to the form BN + \u03bdkBTln N, with coefficient \u03bd = 1.6 \u00b1 0.1 for flexible membranes (consistent with self-avoiding branched polymer statistics) and 1.2 \u00b1 0.1 for semiflexible membranes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":18798013,"openaccessinfo":{"externalids":{"MAG":"2076935611","ACL":null,"DOI":"10.1209\/EPL\/I2004-10423-Y","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Anaemia is the most common haematological abnormality encountered by cancer patients. A large European survey of cancer patients (n = 15,367) reported that 67% had anaemia at some point during the survey, and that over 60% of these patients did not receive any treatment for their anaemia. Two other surveys (the FATIGUE surveys) showed that over 75% of cancer patients experienced fatigue at least monthly, with over 30% reporting this symptom on a daily basis. Significantly, patients regarded fatigue as having a greater negative impact on their daily lives than many other cancer- or treatment-related complications, with important emotional and mental consequences including lack of self-motivation, sadness, frustration, and mental exhaustion. Indeed, fatigue was considered so debilitating, 12% of patients felt their quality of life (QoL) was so reduced that they did not wish to continue living. Anaemia is also recognised as an independent predictor of poor prognosis in cancer patients. A systematic review evaluating survival showed a 65% overall increase in the risk of mortality in cancer patients with anaemia. Increasing physicians' awareness of the importance of effectively treating anaemia in cancer patients therefore has the potential to improve prognosis as well as QoL.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26295486,"openaccessinfo":{"externalids":{"MAG":"2058572764","ACL":null,"DOI":"10.1159\/000088282","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Upper respiratory infections and allergic rhinitis are common diseases in children. In recent years, U.S. Food and Drug Administration has been promoting pediatric drug development with marketing exclusivity incentives and requirements. The assessment of clinical pharmacology, efficacy, and safety data has facilitated pediatric drug development and provided appropriate labeling for pediatric use. Regulatory decision making involves multiple evaluation processes, including drug exposure comparison between adult and pediatric population, formulation bridging, dose selection, and evaluation of efficacy and safety in pediatric patients. This article reviews the pediatric drugs indicated for cough, cold, and allergic rhinitis, focusing on the utility of clinical pharmacology, safety, and efficacy data in determining the pediatric dosing regimen and the approaches taken for regulatory decision making.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":31634491,"openaccessinfo":{"externalids":{"MAG":"2011676686","ACL":null,"DOI":"10.1002\/jps.23720","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We explored the radiation hydrodynamics of tin microsphere targets exposed to 1-\u03bcm, 8-ns laser pulses, and compared them with thick planar targets. Previous research [1] has shown that the conversion efficiency of laser light to in-band emissions around 13.5 nm is lower in microsphere targets. Our work was designed to elucidate the reasons for this drop in emission. Differences in plasma expansion, laser absorption and atomic emissions were measured in the UCSD Laser Plasma Laboratory and modeled using the 2D radiation hydrodynamic code h2d. Experimental data are compared with modeling and differences between emissions in planar and spherical targets explained.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":137224217,"openaccessinfo":{"externalids":{"MAG":"2074243121","ACL":null,"DOI":"10.1088\/1742-6596\/112\/4\/042060","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/112\/4\/042060\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The histology of the suckered, buccal sensory, and respiratory tube-feet and their ampullae, where they occur, of the clypeasteroid sea-urchin Echinocyamus pusillus is described. Each suckered tube-foot possesses two sets of special muscles for attachment and detachment, a ring of mucous glands to assist in attachment, and a ring of sensory cilia. The stem retractors are in four columns, whose differential contraction provides the means of postural movement relative to the test. The ampullae of these tube-feet are exceedingly thin-walled, apparently musculo-epithelial, with anastomosing contractile elements. The canal between tube-foot and ampulla contains a swollen coelomic epithelium which may help to maintain the nerve relationships of the system. The activity of the suckered tube-feet is compared with that of the tubefeet of the starfish, Asterias rubens . The buccal tube-feet, larger than the suckered tube-feet, have large disks underlain by a thick nerve plexus supported by transverse fibres; a ring of sensory cilia surrounds the disk. They have no mucous glands and no suckers, and are presumably entirely sensory, probably both tactile (the cilia) and chemoreceptive (the disk). The respiratory tube-feet are thin-walled sacs, the walls consisting of an outer ciliated and an inner non-ciliated (coelomic) epithelium with cross-connexions for support; where the coelomic epithelium lines the pair of canals through the test it is heavily ciliated. In the specializations of its tube-feet this urchin is shown to share some features with the regular urchins and others with the spatangoids.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":88844518,"openaccessinfo":{"externalids":{"MAG":"2554859720","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Radarsat and JERS-1 imagery were used for mapping zonation of vegetation communities in the Amazon floodplain. Imagery analysis indicates that at periods of minimum water level the backscattering values of both C and L bands are the lowest and as the water level rises, so do the backscattering values. JERS-1 imagery exhibits a larger dynamic range of backscattering in response to the ground cover for the two extremes of water level (10\u2009dB) compared to Radarsat imagery. The backscattering differences from different ground cover allowed the use of a region-based classification that produced seasonal maps with accuracies higher than 95% for vegetated areas of the floodplain. These seasonal maps were used to estimate the spatial distribution and time of inundation and the vegetation cover of the floodplain. It was possible to determine that semi-aquatic vegetation, tree-like aquatic plants, and shrub-like trees colonize regions flooded for at least 300\u2009days\u2009year\u22121. Secondary colonizers, such as tall well-developed floodplain forest, cover regions flooded for approximately 150\u2009days\u2009year\u22121, and floodplain climax forest colonize regions inundated for approximately 60\u2009days\u2009year\u22121.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":129599681,"openaccessinfo":{"externalids":{"MAG":"2124949832","ACL":null,"DOI":"10.1080\/0143116031000116985","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Orthogonal Frequency Division Multiplexing (OFDM) has become the popular modulation technique in high speed wireless communications. One of the main disadvantages of Orthogonal Frequency Division multiplexing (OFDM) is its high Peak-to-Average Power Ratio (PAPR), which significantly reduces the efficiency of the High Power Amplifier (HPA). Due to the simplest way for PAPR reduction, clipping techniques are frequently used in practice for OFDM PAPR reduction. In this paper, Classical-Clipping (CC), Deep-Clipping (DC) and SmoothClipping (SC) are implemented for reducing the PAPR of an OFDM system. The effectiveness of these techniques in terms of PAPR-reduction average power variation and total system degradation are evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":14612317,"openaccessinfo":{"externalids":{"MAG":"2185405331","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Improved diagnosis of cancer through targeted imaging of neoplasms is needed for early detection and treatment of cancer. We propose that the physical characteristics of filamentous bacteriophage (phage) are well suited for use in the targeted imaging of cancer. This study describes the development of two different phage-based cancer imaging agents. One is specific for prostate carcinoma, and the other specific for melanoma, with each utilizing different imaging modalities optical imaging and radioimaging. A human PC-3 prostate carcinoma was optically imaged using phage displaying a newly selected prostate homing peptide labeled with the near infrared fluorophore AF680, whereas, a mouse B16-F1 melanoma was radioimaged using single-photonemission-computed-tomography through a two-step pretargeting procedure. This pretargeting strategy utilized bifunctional bacteriophage that were both biotin labeled and displayed \u03b1-melanoma stimulating hormone peptide analogs and included streptavidinchelator complex radiolabeled with In. The successful imaging of prostate carcinoma and melanoma with different strategies exhibits the versatility of phage and highlights their utility in the imaging of cancer.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":90589563,"openaccessinfo":{"externalids":{"MAG":"2607199282","ACL":null,"DOI":"10.32469\/10355\/4590","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32469\/10355\/4590","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper critically evaluates methods used to synthesize boride compounds with emphasis on diborides of the early transition metals. The earliest reports of the synthesis of boride ceramics used impure elemental powders to produce multiphase reaction products; phase-pure borides were only synthesized after processes were established to purify elemental boron. Carbothermal reduction of the corresponding transition metal oxides emerged as a viable production route and continues to be the primary method for the synthesis of commercial transition metal diboride powders. Even though reaction-based processes and chemical synthesis methods are mainly used for research studies, they are powerful tools for producing diborides because they provide the ability to tailor purity and particle size. The choice of synthesis method requires balancing factors that include cost, purity, and particle size with the performance needed in expected applications.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":138825083,"openaccessinfo":{"externalids":{"MAG":"2464472560","ACL":null,"DOI":"10.1557\/JMR.2016.210","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper is part of an emerging line of work at the intersection of machine learning and mechanism design, which aims to avoid noise in training data by correctly aligning the incentives of data sources. Specifically, we focus on the ubiquitous problem of linear regression, where strategyproof mechanisms have previously been identified in two dimensions. In our setting, agents have single-peaked preferences and can manipulate only their response variables. Our main contribution is the discovery of a family of group strategyproof linear regression mechanisms in any number of dimensions, which we call generalized resistant hyperplane mechanisms. The game-theoretic properties of these mechanisms --- and, in fact, their very existence --- are established through a connection to a discrete version of the Ham Sandwich Theorem.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":3284643,"openaccessinfo":{"externalids":{"MAG":"2953237565","ACL":null,"DOI":"10.1145\/3219166.3219175","PubMedCentral":null,"ArXiv":"1805.10693"},"license":null,"url":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3219166.3219175","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Background: Our previous microarray study showed that sevoflurane anesthesia affects the expression of rat genes in multiple organs including the liver. In this study, we investigated whether liver protein expression was altered after propofol, sevoflurane, or isoflurane anesthesia. We also investigated differences in the time course of each drug 24 and 72 h after anesthesia. Methods: Rats were randomly assigned to four groups (non-anesthetized group and three groups anesthetized at each time point, n = 6 per group). A venous catheter was inserted into the caudal vein of all rats. Rats were anesthetized with each agent for 6 h, and the liver was obtained immediately after anesthesia. Proteomic analysis was performed. Results: About 4200 spots in each gel were discriminated, and at least 2619 spots were matched. Using LC-MS\/MS, we identified 47 spots for propofol, 45 spots for sevoflurane, and 21 spots for isoflurane that were differentially expressed (p < 0.05) 0 h after anesthesia. The numbers of altered proteins were 14 and 19 in the isoflurane and sevoflurane groups, respectively, 72 h after anesthesia, but alterations in 40 proteins were seen in the propofol group 72 h after anesthesia. Conclusion: Volatile and intravenous anesthetics affected protein expression in the liver. Alterations were different for each drug, with isoflurane showing fewer altered proteins 0 h after anesthesia than the other two drugs. The time courses of those proteins were also different between individual anesthetics, suggesting fewer alterations in rat liver protein expression with volatile anesthetics than with propofol.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":16014804,"openaccessinfo":{"externalids":{"MAG":"2108849741","ACL":null,"DOI":"10.2174\/1875039701205010008","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/benthamopen.com\/contents\/pdf\/TOPROTJ\/TOPROTJ-5-8.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Recent developments in string theory suggest that cosmic strings could be formed at the end of brane inflation. Supergravity provides a realistic model to study the properties of strings arising in brane inflation. Whilst the properties of cosmic strings in flat space-time have been extensively studied there are significant complications in the presence of gravity. We study the effects of gravitation on cosmic strings arising in supergravity. Fermion zero modes are a common feature of cosmic strings, and generically occur in supersymmetric models. The corresponding massless currents can give rise to stable string loops (vortons). The vorton density in our universe is strongly constrained, allowing many theories with cosmic strings to be ruled out. We investigate the existence of fermion zero modes on cosmic strings in supergravity theories. A general index theorem for the number of zero modes is derived. We show that by including the gravitino, some (but not all) zero modes disappear. This weakens the constraints on cosmic string models. In particular, winding number one cosmic D-strings in models of brane inflation are not subject to vorton constraints. We also discuss the effects of supersymmetry breaking on cosmic D-strings.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15866323,"openaccessinfo":{"externalids":{"MAG":"2039328602","ACL":null,"DOI":"10.1088\/1126-6708\/2006\/06\/030","PubMedCentral":null,"ArXiv":"hep-th\/0604198"},"license":null,"url":"http:\/\/iopscience.iop.org\/article\/10.1088\/1126-6708\/2006\/06\/030\/pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper addresses the application of an intelligent optimal control system (IOCS) to control an indirect field-oriented induction servo motor drive for tracking periodic commands via a wavelet neural network. With the field orientation mechanism, the dynamic behavior of an induction motor is rather similar to a linear system. However, the uncertainties, such as mechanical parametric variation, external load disturbance and unmodeled dynamics in practical applications, influence the designed control performance seriously. Therefore, an IOCS is proposed to confront these uncertainties existing in the control of the induction servo motor drive. The control laws for the IOCS are derived in the sense of the optimal control technique and Lyapunov stability theorem, so that system-tracking stability can be guaranteed in the closed-loop system. With the proposed IOCS, the controlled induction servo motor drive possesses the advantages of good tracking control performance and robustness to uncertainties under wide operating ranges. The effectiveness of the proposed control scheme is verified by both simulated and experimental results. Moreover, the advantages of the proposed control system are indicated in comparison with the sliding-mode control system.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":46551873,"openaccessinfo":{"externalids":{"MAG":"2154141456","ACL":null,"DOI":"10.1109\/TIE.2002.807672","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Arthroscopic suture fixation of tibial eminence fractures using FiberWire is a favorable therapeutic option. The application of biodegradable material may be of advantage especially during childhood. The aim of this study was to evaluate the biomechanical properties using the biodegradable suture materials PDS II and Vicryl compared with FiberWire. Methods: Bone mineral density was evaluated by pqCT in 18 human knee specimens and 3 similar groups were formed. A standardized anterior tibial eminence fracture was created and suture fixation was performed using each suture material (PDS II, Vicryl, FiberWire) in 6 specimens. Cyclic testing and destructive loading to failure was conducted. Results: Both testing modalities showed PDS II to be inferior to the other evaluated suture materials. Although significantly higher failure loads were seen with FiberWire sutures, Vicryl yielded comparable stiffness in load-to-failure testing. No significant differences between Vicryl and FiberWire could be observed under nondestructive cyclic conditions. Conclusions: Even though FiberWire yields a superior ultimate failure load, Vicryl presented comparable results under cyclic conditions. Clinical Relevance: For tibial eminence fractures in children, Vicryl should be considered as an alternative biodegradable suture material. The use of PDS II cannot be advocated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7207642,"openaccessinfo":{"externalids":{"MAG":"2314108970","ACL":null,"DOI":"10.1097\/BPO.0b013e31827d0c67","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A newly designed six-week course, Palliative Medicine, for second-year medical students at the Medical College of Wisconsin is described. A previous course on death and dying received unfavorable student reviews related to an emphasis on philosophical and theoretical concepts concerning death. The new course presented the concepts of palliative medicine in the context of practical clinical care issues and physician-patient-family communication issues. Student evaluations were very favorable. Implications for legitimizing palliative care in the United States are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25542986,"openaccessinfo":{"externalids":{"MAG":"2322512035","ACL":null,"DOI":"10.1080\/08858199309528228","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a single phase dynamic voltage restorer (DVR) topologies to mitigate voltage sag. A single phase matrix converter (SPMC) is presented as a direct ac-ac converter replacing the voltage source inverter in a typical DVR system. A simulation was done using Matlab\/Simulink software to observe the SPMC performance towards mitigating the voltage sag. In this simulation a single line to ground fault is used to create the disturbance to the load and a Sinusoidal Pulse Width Modulation (SPWM) strategy is used as the switching technique to control the switches.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41413257,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/peds.2013.6527212","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Bagan tancap is a conventional fishing using diesel as its main source. This conventional method needs to be replaced with an eco-friendly and easy to use system, namely solar panels. The solar panels power is just limited by time so the stability of the system is poorly maintained that needs to be a battery as a storage of energy to improve system stability. However, the power that is not optimal causes the charging battery to take longer and not be constant with periods of weather and irradiation coditions. The charging battery without MPPT it tends not to be optimal because the solar panel does not operate at its maximum value. MPPT with perturb and observe algorithms can maximize power on solar cells with tracking speeds that depend on the response speed of the converter. While boost coverter has the ability to maintain potential differences that are tailored to the battery specifications and keep the current and voltage ripple values relatively small. For this reason, this final project will design and implement solar charge controller equipped with MPPT P & O (Perturb and Observe) and boost converter, this method can maximize the power of the solar panel by 97.84% with a faster charging time for 27 minutes. Keywords\u2014Light Fishing, MPPT, Perturb and Observe, Solar Charge Controller","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":225006634,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A century ago, at the beginning of the Great War, which Pope Benedict XV termed a \"pointless slaughter,\" another notable American was born: the Cistercian monk Thomas Merton. He remains a source of spiritual inspiration and a guide for many people. In his autobiography he wrote: \"I came into the world. Free by nature, in the image of God, I was nevertheless the prisoner of my own violence and my own selfishness, in the image of the world into which I was born. That world was the picture of Hell, full of men like myself, loving God, and yet hating him; born to love him, living instead in fear of hopeless self-contradictory hungers.\" Merton was above all a man of prayer, a thinker who challenged the certitudes of his time and opened new horizons for souls and for the Church. He was also a man of dialogue, a promoter of peace between peoples and religions.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":171672873,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1353\/bcs.2017.0005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Part I. Universal Constructions: 1. The Stone-Cech compactification ssT Appendix to Chapter 1. Ultrafilters and the construction of ssT 2. Flows and their enveloping semigroups 3. Minimal sets and minimal right ideals 4. Fundamental notions 5. Quasi-factors and the circle operator Appendix to Chapter 5. The Vietoris topology on 2^X Part II. Equivalence Relations and Automorphisms: 6. Quotient spaces and relative products 7. Icers on M and automorphisms of M 8. Regular flows 9. The quasi-relative product Part III. The tau-Topology: 10. The tau-topology on Aut(X) 11. The derived group 12. Quasi-factors and the tau-topology Part IV. Subgroups of G and the Dynamics of Minimal Flows: 13. The proximal relation and the group P 14. Distal flows and the group D 15. Equicontinuous flows and the group E Appendix to Chapter 15. Equicontinuity and the enveloping semigroup 16. The regionally proximal relation Part V. Extensions of Minimal Flows: 17. Open and highly proximal extensions Appendix. Extremely disconnected flows 18. Distal extensions of minimal flows 19. Almost periodic extensions 20. A tale of four theorems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":262659785,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1017\/CBO9781107416253.018","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fake news can originate from an ordinary person carelessly posting what turns out to be false information orfrom the intentional actions of fake news factory workers,but broadly speaking it can also originate from scientific fraud. In the latter case, the article can be retracted upon discovery of the fraud. A case study shows, however, that such fake sciencecan be visible in Google even after the article was retracted, in fact more visible thanthe retraction notice. We hypothesize that the reason for this lies in the popularity-based logic governing Google, in particular its foundational PageRank algorithm,in conjunction with a psychological law which we refer to as the \"law of retraction\": a retraction notice is typically taken to be less interestingand therefore less popular with internet users than the original content retracted. We conduct anempiricalstudy drawing on records of articles retracted due to fraud (fabrication of data) in the Retraction Watch public database. The study tests the extent to which such retracted scientific articles are still highly ranked in Google \u2013and more so than information about the retraction. We find, among other things, thatboth Google Search and Google Scholar more often than not rankeda link to the original article higher than a link indicating that the article has been retracted.Surprisingly, Google Scholar did not perform better in this regard than Google Search.We also foundcases in which Google didnot track the retraction of anarticle on the first result page at all.We conclude thatboth Google Search and Google Scholar runthe risk of disseminating fake science through theirranking algorithms. (Less)","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":215949178,"openaccessinfo":{"externalids":{"MAG":"3010534418","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An overview of the financial status of professional sports leagues in North America is provided. It reveals that they face similar challenges to those confronting professional soccer teams in England: most teams report annual operating losses; costs, primarily attributed to players' salaries, are accelerating at a level which outstrips the large growth in revenues that is also occurring; and the wealthiest teams tend to dominate competitions on the playing field. The North American leagues' problems of falling attendance, declining ratings, and an economic disconnect with their fan base all contribute to the leagues' declining financial health. Strategies used by leagues to control player costs are described.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":29928610,"openaccessinfo":{"externalids":{"MAG":"2110614724","ACL":null,"DOI":"10.1080\/13606710210163364","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Sugarcane bagasse is a by-product of sugarcane processing and it is rich in insoluble dietary fibers. The objective of this study was to develop cookies enriched with sugarcane bagasse as a fiber source with no added sugars. Bagasses with or without peel were collected from a jaggery manufacturing plant and they were dried, grinded, and sieved to obtain powder (moisture content, 3%). The fiber content (%, wet weight basis) of bagasse powders with and without peel were 12.43\u00b10.30 and 8.61\u00b10.38, respectively. Furthermore, the bagasse with peel contained the highest total phenolic content (1270.89\u00b13.36 \u00b5g GAE\/ g) than bagasse without peel (721.41\u00b10.33 \u00b5g GAE\/g). In addition, water holding capacities (WHC) of with peel and without peel bagasse were 4.85\u00b12.91 and 8.04\u00b11.78 g of water\/g of bagasse powder, respectively. These two types of bagasse powders at 0% (control), 5%, and 10% (w\/w) ratios were enriched to develop cookies. Texture analysis revealed that bagasse with peel enriched cookies were shown optimum hardness compare to the bagasse without peel cookies. According to the sensory evaluation, the 5% bagasse with peel enriched cookies showed the highest overall acceptability than other bagasse enriched cookies but lesser overall acceptability than the control. Collectively, these results suggest that the potential incorporation of sugarcane bagasse (with peel at 5%, w\/w) is acceptable in cookies manufacturing. Keywords: bagasse, by-products, cookies, sugarcane, value-addition","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":198356750,"openaccessinfo":{"externalids":{"MAG":"2954664662","ACL":null,"DOI":"10.4038\/VJS.V22I1.6062","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A solution of the Navier-Stokes equations is given for an incompressible stagnation point flow whose magnitude oscillates in time about a constant, non-zero, value (an unsteady Hiemenz flow). Analytic approximations to the solution in the low and high frequency limits are given and compared with the results of numerical integrations. The application of these results to one aspect of the boundary layer receptivity problem is also discussed.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":123681037,"openaccessinfo":{"externalids":{"MAG":"2068945552","ACL":null,"DOI":"10.1098\/rspa.1982.0153","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Episiotomy is one of the most common obstetric procedures. However, restrictive use of episiotomy has led to a decrease in its use in the United States. Historically, mediolateral episiotomy has been performed less often than median episiotomy in the United States, but both have purported advantages and disadvantages. Emerging research on episiotomy and obstetric anal sphincter injuries has led to an examination of the effects of mediolateral episiotomy. This article describes performance of a mediolateral episiotomy in a situation of fetal bradycardia. Technical aspects of the incision and repair are described, and outcome data and knowledge gaps are summarized. Implications for practice, clinical competency, and education are reviewed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":214694368,"openaccessinfo":{"externalids":{"MAG":"3013022982","ACL":null,"DOI":"10.1111\/jmwh.13096","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Understanding set-up uncertainty effects on dose distributions is an important clinical problem but difficult to model accurately due to their dependence on tissue inhomogeneities and changes in the surface contour (i.e., variant effects). The aims are: (1) to evaluate and quantify the invariant and variant effects of set-up uncertainties, contour changes and tissue inhomogeneities on target dose-volume histograms (DVHs); (2) to propose a method to interpolate (variant) DVHs. We present a lung cancer patient to estimate the significance of set-up uncertainties, contour changes and tissue inhomogeneities in target DVHs. Differential DVHs are calculated for 15 displacement errors (with respect to the isocenter) using (1) an invariant shift of the dose distribution at the isocenter, (2) a full variant calculation, and (3) a B-spline interpolation applied to sparsely sampled variant DVHs. The collapsed cone algorithm was used for all dose calculations. Dosimetric differences are quantified with the root mean square (RMS) deviation and the equivalent uniform dose (EUD). To determine set-up uncertainty effects, weighted mean EUDs, assuming normally distributed displacement errors, are used. The maximum absolute difference and RMS deviation in the integral DVHs' relative dose between (1) the invariant and calculated curves are 65.2% and 5.8% and (2) the interpolated and calculated curves are 16.9% and 2.5%. Similarly, the maximum absolute difference and RMS deviation in mean EUD as a function of the set-up uncertainty's standard deviation between (1) the invariant and calculated curves are 0.02 and 0.01 Gy; and (2) the interpolated and calculated curves are 0.01 and 0.006 Gy. Since a \"worst-case\" example is selected, we conclude that, in the majority of clinical cases, the variant effects of contour changes, tissue inhomogeneities and set-up uncertainties on EUD are negligible. Interpolation is a valid, efficient method to approximate DVHs.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":19690083,"openaccessinfo":{"externalids":{"MAG":"1983553805","ACL":null,"DOI":"10.1118\/1.1508800","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Pancreatic pseudocyst is a usual complication of chronic pancreatitis. Diagnosis is usually established with the help of cross-sectional imaging. Typical presenting complaints are abdominal pain and vomiting. However, atypical presentations of pseudocyst of the pancreas continue to puzzle clinicians throughout the world, leading to difficulty in diagnosis and hence, the development of life-threatening complications. Here, we report a case of a 47-year-old male who was a known case of chronic pancreatitis related to alcoholism presenting with dyspnea, dysphagia, chest pain, and vomiting with a blood pressure of 70\/50 mmHg, which upon evaluation revealed to be a case of peripancreatic pseudocysts extending into mediastinum abutting inferior vena cava and right atrium presenting as acute shock syndrome. The patient was managed with ultrasound-guided pigtail insertion and drainage of pseudocyst of pancreas. Eventually, the patient's clinical condition did not allow for surgical exploration of the thorax and the patient succumbed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":246114377,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.7759\/cureus.21433","PubMedCentral":"8856912","ArXiv":null},"license":null,"url":"https:\/\/assets.cureus.com\/uploads\/case_report\/pdf\/82845\/20220219-22276-1v7k7yl.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg\/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32932690,"openaccessinfo":{"externalids":{"MAG":"2083271136","ACL":null,"DOI":"10.3109\/10641968709160037","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/koara.lib.keio.ac.jp\/xoonips\/modules\/xoonips\/download.php?koara_id=AN00062898-00000032-0071","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We illustrate the effects of heterogeneous beliefs about disasters on the equity premium and individual agents' trading activities. When investors disagree about the chances or severity of disasters, those optimistic investors may insure the pessimists against their disaster risk exposure. Due to the highly non-linear relationship between the consumption losses during a disaster and the risk premium, a small amount of risk sharing can significantly attenuate the effect that disasters have on the equity premium. Thus, the equity premium will remain low even when the economy is predominantly occupied by pessimistic investors, but jump up following a disaster. The effects of risk sharing become stronger when the differences in beliefs are large, or when the optimistic agents also have lower risk aversion. Other interesting predictions of the model include a nonmonotonic relationship between the equity premium and the size of the disaster insurance market, as well as a negative relationship between the equity premium and the amount of disagreements about disasters. \u2217Chen is from MIT Sloan School of Management (firstname.lastname@example.com); Joslin is from MIT Sloan School of Management (email@example.com); Tran is from MIT Sloan School of Management (firstname.lastname@example.com). We thank Leonid Kogan, Monika Piazzesi, and Jiang Wang for comments. All the remaining errors are our own.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10130805,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). We have shown that CNS-specific CD8+ T cells possess a disease suppressive function in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). In humans, this suppressive function of CD8+ T cells is deficient during MS relapses. We thus evaluated the role of CD8+ T cells in the context of the relapsing-remitting model (RR-EAE), using SJL mice. We demonstrate here that PLP178\u2013191- and MBP84\u2013104-specific CD8+ T cells ameliorated disease severity in an antigen-specific manner. Moreover, PLP178\u2013191 CD8+ T cells reduced the number of relapses in PLP178\u2013191-induced disease, even when transferred during ongoing disease. We were further able to ascertain that the suppressor population of CD8+ T cells express CD25, and show that a very low number of CD25+ CD8+ T cells are sufficient to suppress RR-EAE. We also probed the role of endogenously generated CNS-specific CD8+ T cell responses by using Listeria monocytogenes (LM) encoding CNS antigens to preferentially prime suppressive CD8+ T cells in vivo. Using this system, we show infection with LM expressing PLP175\u2013194 endogenously induced disease suppressive CD8+ T cells that protected and treated PLP178\u2013191 disease. Importantly, a combination of CD8+ T cell transfer boosted by LM infection also successfully treated ongoing disease induced by a non-cognate peptide (PLP139\u2013151), indicating that this approach could be effective even in the context of epitope spreading. These studies support a potential immunotherapeutic strategy using LM vaccination to prime disease regulatory CD8+ T cells.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":255650947,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.202.supp.193.11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Several recent papers have made claims about the detection of an asymmetric distribution of large-scale power in the cosmic microwave background (CMB) anisotropy as measured by the WMAP satellite. In this paper, we investigate how the estimates of particular cosmological parameters vary when inferred from power spectra computed separately on the Northern and Southern hemispheres in three frames of reference: the galactic, the ecliptic and the specific frame of reference that maximizes the asymmetry between the power spectra from the corresponding hemispheres. The study is intended to quantify the consistency of the observed spectral variations in the context of the inflationary scenario inspired models with which the data are commonly compared. We focus on the three specific parameters to which the analysis is most sensitive (spectral index n, amplitude of fluctuations A and optical depth) and find interesting variations in their estimates as determined from different hemispheres. Only multipoles in the ranges l = 2- 60, 200- 240 and 520- 560 (the latter two around the first two peaks) are included in the analysis. Polarization information could not be used since the appropriate sky maps are not publicly available. Furthermore, we fix Omega(Lambda) = 0.74, Omega(cdm) h(2) = 0.11 and Omega(total) = 1 atthese best-fitting values obtained by the WMAP team, and use a Gaussian prior centred at Omega(b)h(2) = 0.022 with sigma = 0.001 for the baryon fraction. No significant changes to the conclusions were found when these parameters were varied. When using a Gaussian prior on the spectral index n centred at n = 1 with a flat prior on the optical depth, the preferred value for the optical depth (derived in the reference frame of maximum asymmetry) in the Northern hemisphere is tau = 0 with upper limit tau < 0.08, whereas in the Southern hemisphere we find = 0.24(-0.07)(+0.06) (68 per cent confidence level). The latter result is inconsistent with = 0 at the 2sigma level. The estimated optical depth of tau = 0.17 on the (nearly) full sky found by the WMAP collaboration, and confirmed independently here, could thus in large part originate in structure associated with the Southern hemisphere. Furthermore, putting a prior on,we find values of the spectral index that are inconsistent between the two hemispheres. The exact values depend on the prior on. Our conclusions remain unaltered even when, on the basis of putative residual foreground contamination, the multipole range l = 2- 7 is excluded from the analysis. While our results should not be considered more than suggestive, the significance of the parameter differences in the two hemispheres being typically of order 2sigma ,if they are confirmed with the higher-sensitivity WMAP 2-yr data, then it may be necessary to question the assumption of cosmological isotropy and the conceptual framework within which studies of CMB anisotropy are made.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":15219261,"openaccessinfo":{"externalids":{"MAG":"3101522506","ACL":null,"DOI":"10.1111\/j.1365-2966.2004.08243.x","PubMedCentral":null,"ArXiv":"astro-ph\/0406232"},"license":null,"url":"https:\/\/academic.oup.com\/mnras\/article-pdf\/354\/3\/905\/18658425\/354-3-905.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Despite the sustained use of forcefield methodologies to study SiO(2) polymorphs few reviews on the subject are available in the literature. The present study is an attempt to help fill this gap, focusing on classical forcefields used to reproduce and predict properties of pure silica zeolites (or zeosils) such as cell parameters, SiO distance and especially pore size. Instead of an exhaustive study we have focused on an application where diffusion of hydrocarbons makes important the use of pure silica zeolites. A particular area of interest is small pore zeosils containing 8-rings as the largest window, which are industrially interesting for their ability to perform kinetic separations of mixtures of C3 hydrocarbon molecules whose dimensions are of similar characteristics. A set of forcefields have been selected from the literature to analyze their accuracy and transferability when predicting structural, mechanical and dynamical properties of small pore pure silica zeolites and their performance at selective diffusion of C3 hydrocarbons.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2013-20":1,"unknown":2}},"corpusid":11992829,"openaccessinfo":{"externalids":{"MAG":"2076115185","ACL":null,"DOI":"10.1039\/c2cs35243e","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"TO THE EDITOR: We would like to congratulate Stohr et al. (3) on their interesting and timely examination of left ventricular (LV) rotational mechanics during submaximal exercise. We (2) have previously acknowledged the importance of evaluating LV rotation during incremental to maximal exercise. It is great to see novel techniques applied to answer such fundamental questions. Although we found this article interesting, we would like to highlight some issues that may deserve further consideration. First, we would like to comment on the technical aspects of imaging the LV during exercise. Quantification of LV twist heavily relies on apical rotation (2). Accurately imaging the short axis of the apex during exercise is extremely challenging because of the increased heart and respiration rates. To be accurate, the longitudinal location of the image must be exactly repeated over each exercise stage. We expect that as exercise intensity increased, so did the difficulty of recording motion at identical locations. Support for this contention is the finding of a marked and progressive increase in the variability in apical rotation velocity as exercise intensity increased, whereas the variability in basal rotation was relatively consistent (3). In our experience, as apical rotation rate directly increases through an increase in heart rate, images become less clear. Following this, it may be possible that the point perceived as the \"luminal obliteration\" progressively becomes a more basal location as exercise intensity increased (4). If this occurred, changes in twist may be undetectable at higher exercise intensities. Second, although we have used the Teichholz method for determining stroke volume (SV), questions remain about its validity during exercise (in particular, high-intensity exercise). It follows that a possible limitation of this technique may lie in the aforementioned technical considerations thought to occur at the apex. If this is the case, it may have influenced the accuracy of SV estimates, since they were derived from short-axis images at the level of the papillary muscle. It would add to the specific discussion regarding SV and LV twist changes if the relationship was separately plotted for above and below the point of 50% SV increase. Our visual interpretation of Fig. 5 (3) suggests that the relationship between values becomes less clear above 50% SV increase. Although this point is partially documented in the discussion, the presence of SV changes during exercise is highly dependent on training status and postural position. Therefore, we are not sure that this study either supports or refutes either side of the ongoing debate (1, 5). This is particularly salient since considerable recent research (using techniques validated for maximal exercise) has shown that there is often a slight plateau in SV, with a further increase at maximal exercise. The fact that maximal exercise was not evaluated is a limitation, and as such all statements regarding SV plateauing should be tempered accordingly. Moreover, the authors have not presented the individual data of the participants, limiting the ability to interpret the varied responses to exercise. It appears from the mean data that SV may have not reached a true plateau in many participants (a finding that is consistent with the literature) (5). We applaud Stohr and colleagues (3) for their interesting work. Although there were several important limitations that required mention, we feel the application of techniques used in their work is the natural progression of this ongoing discussion.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":45243331,"openaccessinfo":{"externalids":{"MAG":"2157473045","ACL":null,"DOI":"10.1152\/ajpheart.00834.2011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Seasonal changes in an animal's morphology, physiology, and behavior are considered to be an adaptive strategy for survival and reproductive success. We hypothesize that Apodemus chevrieri will change their thermogenesis seasonally and serum leptin will change with body mass or body fat mass. Seasonal variations in body mass (BM), basal metabolic rate (BMR), nonshivering thermogenesis (NST), digestive tract morphology, serum leptin and uncoupling protein 1 (UCP1) were measured in wild-trapped A. chevrieri in Hengduan mountain region. The results showed that the body weight of A. chevrieri was lowest in winter and highest in summer. Decreased BM in the winter was accompanied by increased energy intake and enhanced NST and UCP1 as well as by decreased body fat mass, adjusted digestive tract morphology and reduced levels of circulating leptin. Further, serum leptin were positively correlated with body weight and body fat mass, and negatively correlated with energy intake and UCP1 contents. These data suggest that wild A. chevrieri do not depend on a decrease in BM, but instead increase their thermogenic capacity to cope with cold stress. Leptin may be involved in the seasonal regulation in energy balance and thermogenesis in field A. chevrieri.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":85349814,"openaccessinfo":{"externalids":{"MAG":"2079228347","ACL":null,"DOI":"10.1163\/157075612X650140","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present a protocol to create entangled coherent states by engineering cross-Kerr interactions between bosonic systems endowed with (externally driven) internal spin-like degrees of freedom. With slight modifications, the protocol is also able to produce N00N states through nonlinear beam splitter interactions. Each bosonic system interacts locally with its spin and by suitably tuning the model parameters, various classes of effective bosonic interaction Hamiltonians, mediated by the coupled spins, can be engineered. Our approach is benchmarked by numerical simulations aimed at studying the entanglement within a bosonic register and comparing it with the expected one resulting from the target Hamiltonians.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":262053800,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2309.10060"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Fire-fighters are trained rescuers especially in extinguishing hazardous fires and saving lives from dangerous situations however they tend to put their lives at risk while on the job. Statistic shows the number of deaths of fire-fighters while on the job are still high up to this year and a higher percentage of rapid fire progress and exertion are dedicated to the cause of death of fire-fighters while on the job. Therefore, a real-time monitoring on the physiological state for fire-fighters is something crucial to be done. However, the Fire and Rescue Department of Malaysia practices the traditional communication method which is by communicating via walkie-talkie. The practice of real-time assessment should be carried out by Fire and Rescue Department of Malaysia in order to avoid having a fire-fighter's live at risk. This could be achieved by using the ARMOR (Android Based Real Time Monitoring System) whereby it can transmit voice data and physiological data such as heart rate, respirator rate, peak acceleration and posture. Based on the research and critical analysis, an android platform have been found to be a suitable selection as it supports Bluetooth Wi-Fi and Radio Frequency, accessible from any android devices and it is user friendly. As a result, a real-time intelligent monitoring system was successfully developed on an android platform. The physiological data for heart rate, respiration rate, posture, and peak acceleration was successfully transmitted and monitored on an android device at real-time.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":133229733,"openaccessinfo":{"externalids":{"MAG":"2935394358","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT MALAT1 is associated with dendritic cells (DCs) maturation in Atherosclerosis (AS). This article aims to demystify the role of MALAT1 in AS. We separated immature DCs (iDCs) from healthy volunteers or ApoE-\/- mice. And iDCs were treated with oxidized low density lipoprotein (ox-LDL) to induce DCs maturation. We found that ox-LDL promoted the levels of DCs maturation markers including CD83, CD86, IL-12 and IL-6. MALAT1 and NFIA were down-regulated, whereas miR-155-5p was up-regulated in the ox-LDL-treated iDCs. Furthermore, DCs maturation was notably suppressed by MALAT1 overexpression, NFIA overexpression or miR-155-5p knockdown. Moreover, MALAT1 functioned as a competing endogenous RNA to repress miR-155-5p, which controlled its down-stream target, NFIA. In addition, MALAT1 overexpression inhibited ox-LDL-stimulated DCs maturation by regulating miR-155-5p\/NFIA axis. In AS mice, MALAT1 overexpression attenuated ox-LDL-stimulated DCs maturation and reduced atherosclerotic plaque area. In summary, our study demonstrates that MALAT1 overexpression attenuates AS by inhibiting ox-LDL-stimulated DCs maturation via miR-155-5p\/NFIA axis. Thus, MALAT1\/miR-155-5p\/NFIA axis can potentially be used in the treatment of AS.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221308610,"openaccessinfo":{"externalids":{"MAG":"3080522385","ACL":null,"DOI":"10.1080\/15384101.2020.1807094","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/15384101.2020.1807094?needAccess=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Mitochondrial apoptosis inducing factor (AIF) is a redox-active enzyme that participates to the biogenesis\/maintenance of complex I of the respiratory chain, yet also contributes to catabolic reactions in the context of regulated cell death when AIF translocates to the cytosol and to the nucleus. Here we explore the contribution of AIF to cell death induced by menadione (2-methyl-1,4-naphtoquinone; also called vitamin K3) in conditions in which this pro-oxidant does not cause the mitochondrial release of AIF, yet causes caspase-independent cell killing. Depletion of AIF from human cancer cells reduced the cytotoxicity of menadione. This cytoprotective effect was accompanied by the maintenance of high levels of reduced glutathione (GSH), which are normally depleted by menadione. In addition, AIF depletion reduced the arylation of cellular proteins induced by menadione. This menadione-triggered arylation, which can be measured by a fluorescence assay, is completely suppressed by addition of exogenous glutathione or N-acetyl cysteine. Complex I inhibition by Rotenone did not mimic the cytoprotective action of AIF depletion. Altogether, these results are compatible with the hypothesis that mitochondrion-sessile AIF facilitates lethal redox cycling of menadione, thereby precipitating protein arylation and glutathione depletion.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3558977,"openaccessinfo":{"externalids":{"MAG":"2530329783","ACL":null,"DOI":"10.18632\/oncotarget.12562","PubMedCentral":"5363526","ArXiv":null},"license":"CCBY","url":"http:\/\/www.oncotarget.com\/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12562&path%5B%5D=39807","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Summary form only given, as follows. A report is presented on the use of nonstandard target vectors in the training of the neural network portion of an isolated-word speech recognizer. The speech time waveform is processed into a vector of 320 numbers which are used for training a perceptron-type neural network utilizing backpropagation training. Three types of target-vector codes are used in training the neural network, and it is shown that the use of nonstandard types of orthogonal training vectors can greatly reduce the training time required. It is also shown that a neural network word recognizer achieves accuracy comparable to that of a pattern matching recognizer while requiring an order of magnitude less computing power.<>","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62619803,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multiferroic materials are intensively investigated as potential candidates for a new generation of solar cells, due to the coexistence in their phases of ferroelectricity and magnetic order with low band gap. However, symmetry considerations, which determine the interplay between the magnetoelectric and photovoltaic properties of a light irradiated multiferroic crystal, are not fully taken into account in the current theory of the photovoltaic effect. Here the remarkable photovoltaic and magnetophotovoltaic effects occurring in the multiferroic phase of $\\mathrm{KBiF}{\\mathrm{e}}_{2}{\\mathrm{O}}_{5}$ are described using a theoretical approach that takes directly into account the crystal and light beam wave symmetries.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":124735352,"openaccessinfo":{"externalids":{"MAG":"2202658994","ACL":null,"DOI":"10.1103\/PHYSREVB.93.195123","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Physics of the same sex has been discussed in this paper. Homosexuality and Lesbianism are of this world, fashioned after the carnal lusts of folks of corrupt mind. They are the inevitable products of people with vile imaginations. Looking at homosexuality and lesbianism from the fundamental electric charges and magnetic poles concepts of Physics, we convincingly pointed out that in all ramifications Physics stands stoutly against same sex unions, apart from being condemned by Almighty God. Gayism is going beyond the sexual bond set in marital relationship since the inception of the world by God. An atom that is bombarded with electron will be excited. As excited atom is ground-seeking for stability, so is one who is sexually aroused, craving for sexual release. Sexual excitation and the impacts of sexual thoughts on human activities and acceptable way to release it are addressed. God's immutable reproductive law stands stoutly against homosexuality and Lesbianism. Codes for estimating photon energy, frequency, wavelength, number of electrons per orbital shells and quantum number have been provided. The developed functionalities are exposed in a client package together with the step-by-step workings that will aid real-time teaching and learning. The display of spectral lines caused by electron excitation has also been produced with Microsoft Visual Studio, 2013. It is expected that gays who read this article will drop the practice and embrace the wholesome acceptable way of God-ordained mating and relationship. Newsletters","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212626700,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background This project analysed the Integrated Palliative Outcome Scale (IPOS) in a 20-bedded in-patient unit during the COVID-19 Pandemic. The scores were taken at admission, at change in Phase of Illness and at point of discharge or death. These scores were used to monitor symptom progression and effectiveness of management during the COVID-19 pandemic. Methods The Electronic patient record (EPR) identified 110 hospice inpatients, from a total 141 admissions between 1st October 2020 - 31st March 2021) who had at least one IPOS recorded. Initial and subsequent IPOS scores were inputted and analysed in Microsoft Excel and baseline symptom prevalence and outcome measures reported (bar charts and radar plots). Results Over the 6-month period analysed 93% of patients admitted had a primary cancer diagnosis and 7% non-cancer related conditions. The worst rated physical symptoms on admission included;weakness (2.67), poor mobility (2.59) and poor appetite (2.27). Family worry was the top score of all the domains with an average initial admission score of 3.13, this is not unsurprising, and likely that the visiting restrictions in place will be contributing to this domain All physical symptoms were successfully reduced from start to end of admission except for impact of drowsiness. The greatest reductions in average scores of the physical domains were seen for constipation (28.6%), Nausea (23.9%) and Weakness (17.2%). However, average scores for anxiety, depression and sharing feelings rose by 2.3%, 10.5% and 5.7% during the admission. Conclusions This work confirms that an in-patient unit can collect and analyse patient outcomes data, even during a pandemic. The results demonstrate the positive impact that admission to a hospice can have on the symptoms of terminally ill patients, especially physical symptoms. For us it has highlighted areas of improvement especially psychological and spiritual care.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247587061,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/spcare-2022-scpsc.55","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1136\/spcare-2022-scpsc.55","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Under a collaborative interagency agreement between the U.S. Environmental Protection Agency and the U.S. Department of Energy (DOE), the National Renewable Energy Laboratory (NREL) performed a series of in-depth analyses to characterize on-road driving behavior including distributions of vehicle speed, idle time, accelerations and decelerations, and other driving metrics of mediumand heavy-duty vocational vehicles operating within the United States. As part of this effort, NREL researchers segmented U.S. mediumand heavy-duty vocational vehicle driving characteristics into three distinct operating groups or clusters using real-world drive cycle data collected at 1 Hz and stored in NREL's Fleet DNA database. The Fleet DNA database contains millions of miles of historical drive cycle data captured from mediumand heavy-duty vehicles operating across the United States. The data encompass existing DOE activities as well as contributions from valued industry stakeholder participants. For this project, data captured from 913 unique vehicles comprising 16,250 days of operation were drawn from the Fleet DNA database and examined. The Fleet DNA data used as a source for this analysis has been collected from a total of 30 unique fleets\/ data providers operating across 22 unique geographic locations spread across the United States. This includes locations with topographies ranging from the foothills of Denver, Colorado, to the flats of Miami, Florida. This paper includes the results of the statistical analysis performed by NREL and a discussion and detailed summary of the development of the vocational drive cycle weights and representative transient drive cycles for testing and simulation. Additional discussion of known limitations and potential future work is also included.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":67371801,"openaccessinfo":{"externalids":{"MAG":"2797524818","ACL":null,"DOI":"10.4271\/2018-01-1199","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.nrel.gov\/docs\/fy18osti\/70996.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This research aimed to examine the impact of a proposed flow stent (PFS) on different abdominal artery shapes. For that purpose, a finite element-based model using the computational fluid dynamics (CFD) method is developed. The effect of PFS intervention on the hemodynamic efficiency is estimated by all of the significant criteria used for the evaluation of aneurysm occlusion and possible rupture; the flow velocity, pressure, wall shear stress (WSS), and WSS-related indices. Results showed that PFS intervention preserves the effects of high flow rate and decreases irregular flow recirculation in the sac of the aneurysm. The flow velocity decreases inside the aneurysm sac in the range of 55% to 80%. The time-averaged wall shear stress (TAWSS) was reduced from 42% to 53% by FPS deployment. The simulation results implies that PFS could heal an aneurysm efficiently with a mechanism that causes the development of thrombus and ultimately leads to aneurysm resorption.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":247220945,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/1.4053999","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Acute bone decalcification is an essential part of a biological process which, in cases of fracture, leads to bone union. This temporary rare-faction is reflex in nature and proceeds from traumatic irritation of the nerve branches which supply the bone and the periosteum. When the irritation subsides, this process is brought to a standstill and is replaced by deposition of lime salts in the newly formed soft callus and the decalcified ends of the fragments. A soldering of the fragments is thus obtained. In some cases, this irritation of the nerve branches continues for a long period and prevents nature from carrying out the normal healing process. Local deficiency of lime salts causes delay in bone union and may even prevent consolidation.\n\nThe etiology of this condition may be ascribed to unusual involvement of the sensitive nerve branches, due to trauma, or to methods of treatment which tend to maintain the irritation of the afferent nerve conductors. Fractures of the forearm and leg are especially prone to non-union because of their profuse and diversified innervation. In cases of fracture of the forearm, disregard of the rules of reduction and immobiliztion is an important factor in the production of pseudarthrosis. The sensitive nerve branches which may be chiefly accused of sustainihg irritation and favoring non-union appear to originate in the upper part of the limb from the radial-nerve and ulnar-nerve cables. In the lower limb the corresponding sources are the obturator, saphenous, and peroneal nerves. A special branch of the peroneal nerve, located on the dorsum of the foot and known as the cutaneus dorsalis intermedius, has been found by the author to be especially prone to neuritis of a degree capable of producing marked decalcification. Another form of neuritis, associated with the treatment of fractures, arises from the modern free use of nail extension. Indiscriminate piercing of the bone in such profusely innervated regions as the inner side of the knee and the calcaneum frequently gives rise to stubborn neuritis with consequent wide-spread decalcification.\n\nIn the clinical examination of slowly healing fractures more attention should be paid to the possible involvement of the peripheral-nerve branches. Roentgenographic examination should not be limited to the immediate site of injury. Decalcification which extends toward the most distal part of the limb should be regarded as positive proof of existing traumatic neuritis.\n\nAcute bone atrophy plays a conspicuous role in the general pathology of osseous tissue. The aid of physiology and physiological chemistry is needed in solving the problem of this complex process.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78854038,"openaccessinfo":{"externalids":{"MAG":"2512000158","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Many benefits of pre-clinical medical skills training have been documented in more technologically advanced nations, and in the past decade, these courses have been introduced to developing countries. Curriculum that can prepare and build confidence in medical students must be cost effective, evidence-based and culturally sensitive in places where there are severe resource limitations. \u00a0In 2013, an initial pre-clinical skills course without assessments was introduced to medical students in Zambia. Later that year, a more developed course was launched to a second cohort integrating Peer Assisted Learning (PAL) and assessments. These trainers were prepared in advance with instruction in standardized skills, learning theory, effective feedback techniques and use of rubrics to insure good inter-rater reliability in teaching and assessments. \nMethods: A quantitative study surveyed 108 students utilizing convenience sampling and a written questionnaire. Data collected compared preparedness and confidence in performing clinical skills of the intervention cohorts with the control group (medical students who preceded pre-clinical skills training). \nResults: Preparedness responses increased from 36.1% of the students in the control group to 90.9% in the intervention group who had been exposed to the PAL course with assessments (p value <0.001). Student confidence levels in history taking, physical exam skills, procedures and the application of critical thinking skills diagnostically also showed improvement from 11.5-29.5% range in the control group to 77.3-86.4% range in the PAL cohort (p value <0.001). \nConclusions:Exposure to pre-clinical training program especially utilizing PAL with assesments had a positive impact on the sense of preparedness and confidence levels for medical students beginning their clinical training years at the University of Zambia.\u00a0 Integration of PAP influenced academic development, clinical procedural standardization, appropriate curriculum additions, transitional support and program sustainability. PAL may have beneficial application extending to basic science lab instruction in resource limited environments. Recommendation for future research would be integration of qualitative triangulation and reduction of variables in confidence data reporting.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":79033663,"openaccessinfo":{"externalids":{"MAG":"2601449893","ACL":null,"DOI":"10.15566\/CJGH.V4I1.152","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Dermatophytosis is a superficial fungal infection of keratinized tissue. The infection is known as tinea. Various oral and topical antifungal agents used in clinicalpractice. Objective: Comparative study between oral terbinafine and griseofulvin in dermatophytosis infection in children between 5 to 15 years Methods: Patients of both gender and age between 5 to 15 years diagnosed as dermatophytic infection were enrolled for the study. Atotal of 100 patientswere divided into two groups. One group was treated with oral terbinafine and other withoral griseofulvin for 4 weeks. In addition a placebo cream\/ lotion was applied locally. Limitation: Large studies are required for more confirmation. Conclusion: Oral terbinafine produced 88 percent cure while cure with griseofulvin was 72 percent .Clinical response to oral terbinafine was 16percentbetter.No significant adverse effects were noticed in either groups, except in some cases mild gastrointestinal disturbance.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":86531911,"openaccessinfo":{"externalids":{"MAG":"2911375568","ACL":null,"DOI":"10.18231\/2581-4729.2018.0063","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.18231\/2581-4729.2018.0063","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Background: Our previous study found that electroacupuncture (EA) can promote the recovery of neurological functions, reduce the volume of cerebral infarction, and protect the neurovascular unit in middle cerebral artery occlusion (MCAO) rats. Some studies have shown that ferroptosis is closely related to ischemic stroke; however, whether EA plays a protective role by regulating ferroptosis is unknown. Objective: We aimed to investigate the inhibitory effects of EA on ferroptosis in MCAO rats. Methods: We used 36 adult male Sprague\u2013Dawley rats in this study. MCAO rats were established according to the Zea method and treated with EA at a continuous wave of 2\/100 Hz and ~2\u20134 V for 30 min for 7 consecutive days. We analyzed the coordinated motor deficit and volume of cerebral infarction in vivo through 9.4-tesla magnetic resonance imaging. Then, the ischemic brain tissue was isolated and the levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and iron were determined. Western blotting and real-time quantitative PCR were performed to evaluate the expression of glutathione peroxidase 4 (GPX4), transferrin (Tf), transferrin receptor 1 (TfR1), and ferritin heavy chain 1 (FTH1). To confirm the results, we used a transmission electron microscope to observe the mitochondrial morphology. Results: EA intervention significantly decreased the oxidative stress level and inhibited ferroptosis. EA significantly improved coordinated motor deficit (P < 0.01) and decreased cerebral infarct volume (P < 0.01) in the EA + MCAO group, compared with the MCAO group. EA downregulated the level of MDA (P < 0.01) and total iron (P < 0.01) and upregulated the level of SOD (P < 0.01) and GSH (P < 0.01) in the EA + MCAO group, compared with the MCAO group. EA increased the levels of GPX4 and GPX4 mRNA (P < 0.01) and FTH1 and FTH1 mRNA (P < 0.05, P < 0.01), whereas it decreased the levels of Tf and Tf mRNA (P < 0.05, P < 0.01) and TfR1 and TfR1 mRNA (P < 0.01) in the EA + MCAO group, compared with the MCAO group. EA also promoted the recovery of mitochondrial morphology according to the mitochondrial classification system for the ischemic cerebral tissue. Conclusion: Our results indicate that EA can inhibit ferroptosis by regulating oxidative stress and iron-related proteins, thus conferring protection against MCAO in a rat model.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":232136745,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fneur.2021.619043","PubMedCentral":"7982901","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.619043\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In industry the development of software applications is usually a complex and demanding task, and the design and the technical realisation is often spread among different roles, which leads to a time consuming and error-prone exchange of knowledge. In order to ensure the correct translation from business idea to implementation it is crucial to allow for the correct and complete exchange of information between these roles. In this paper, we describe an automated mapping from business process diagrams to agent concepts that simplify the transfer of knowledge between the roles involved in the software development process. Our approach benefits from building upon an intuitive visual specification language on the one hand, and from using a powerful and flexible execution platform on the other.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":17810710,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract We present the geometry behind counting twin prime polynomials in $\\mathbb{F}_{q}[T]$ in general. We compute cohomology and explicitly count points by means of a twisted Lefschetz trace formula applied to these parametrizing varieties for cubic twin prime polynomials. The elliptic curve $X^{3}=Y(Y-1)$ occurs in the geometry, and thus counting cubic twin prime polynomials involves the associated modular form. In theory, this approach can be extended to higher degree twin primes, but the computations become harder. The formula we get in degree 3 is compatible with the Hardy\u2013Littlewood heuristic on average, agrees with the prediction for $q\\equiv 2$ (mod 3), but shows anomalies for $q\\equiv 1$ (mod 3).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":119317168,"openaccessinfo":{"externalids":{"MAG":"2995884276","ACL":null,"DOI":"10.4153\/CJM-2018-018-9","PubMedCentral":null,"ArXiv":"1711.05564"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Colorectal cancer (CRC) is now the second most deadly cancer globally. Chinese herbal medicine (CHM) plays an indispensable role in CRC treatment in China. However, the core herbs (the CHs) in the treatment of CRC and their underlying therapeutic mechanisms remain unclear. This study aims to uncovering the CHs and their mechanisms of action of CRC treatment, applying data mining and network pharmacology approach. First, CHM prescriptions treating CRC were collected from clinical studies from the Chinese National Knowledge Infrastructure (CNKI) and MEDLINE databases, and the CHs were identified through data mining. Then, the bioactive compounds and the corresponding putative targets of the CHs were obtained from three traditional Chinese medicine (TCM) databases. CRC related targets were acquired from three disease databases; the overlapping targets between the CHs and CRC were identified as the therapeutic targets. Subsequently, functional enrichment analysis was performed to elucidate the mechanisms of the CHs on CRC. Moreover, networks were constructed to screen the major bioactive compounds and therapeutic targets. Finally, prognostic values of the major target genes were evaluated by survival analysis, and molecular docking simulation was performed to assess the binding affinity of key targets and major bioactive compounds. It came out that 10 the CHs from 113 prescriptions and 190 bioactive compounds with 118 therapeutic targets were identified. The therapeutic targets were mainly enriched in the biological progress of transcription, apoptosis, and response to cytokine. Various cancer-associated signaling pathways, including microRNAs, TNF, apoptosis, PI3K-Akt, and p53, were involved. Furthermore, 15 major bioactive compounds and five key target genes (VEGFA, CASP3, MYC, CYP1Y1, and NFKB1) with prognostic significance were identified. Additionally, most major bioactive compounds might bind firmly to the key target proteins. This study provided an overview of the anti-CRC mechanisms of the CHs, which might refer to the regulation of apoptosis, transcription, and inflammation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":226392518,"openaccessinfo":{"externalids":{"MAG":"3097940610","ACL":null,"DOI":"10.1155\/2020\/8325076","PubMedCentral":"7641702","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/8325076.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The macroscopic and microscopic anatomy of the hemipenis of the snake Bitis arietans arietans were investigated. Each hemipenis appeared as a bilobed structure. By using SEM at low magnifications, the two lobes of the hemipenis appeared to form, at the base, a sharp angle. The two lobes are provided with a well-developed arrangement of sharp, sloping spines or hooks. In general, most of the spines are directed backward. Histologically a pleated epithelium covers the hemipenis. This epithelium is very thin at the tips of the spines, but gradually thickens as it goes basally to become continuous with that in between the spines. The above epithelium cov\u00ad ers a special kind of fibrous connective tissue which is provided with a well developed network of venous sinuses. The spines are provided with car\u00ad tilagenous cones embedded in a fibrous connective tissue. At the back of the large lobe of the hemipenis there are numerous strands of striated muscles as a continuation of the propulsar muscle.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":86265209,"openaccessinfo":{"externalids":{"MAG":"2186523496","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: This paper explores the context and the process by which culture became integral to revolution in the early years of the Chinese Communist Revolution. It draws attention to the educational program that a group of urban-based Communist intellectuals initiated among urban laborers and other workers after the Nationalist Party's suppression of the Communist labor movement in 1927. Rather than an economic and political revolution, these Communists envisioned a \"cultural and thought movement\" that would transform laborers' ways of seeing and living everyday life. By guiding workers' literary writings and provoking social scientific and philosophical discussions, they worked to transform workers' consciousness about their everyday experiences. They believed this consciousness would engender resistance to capitalist oppression in incremental and concrete ways and that a political and economic revolution would emerge from these daily actions at an opportune time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201781441,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1353\/tcc.2017.0016","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: Glucagonoma is an extremely rare neuroendocrine tumor that arises from pancreatic islet alpha cells. Although glucagonoma is usually accompanied by a variety of characteristic clinical symptoms, early diagnosis is still difficult due to the scarcity of the disease. Methods: In this study, we present the cumulative experiences, clinical characteristics and treatments of seven patients diagnosed with glucagonoma during the past 10 years at the First Affiliated Hospital of Xi'an Jiaotong University. Results: The seven patients in our cohort consisted of six females and one male with an average diagnosis age of 40.1 years (range 23-51). The average time from onset of symptoms to diagnosis of glucagonoma was 14 months (range 2-36 months). All the patients visited dermatology firstly for necrolytic migratory erythema (NME) 7\/7 (100%), other presenting symptoms included: diabetes mellitus (DM) 4\/7 (57%), stomatitis 2\/7 (28%), weight loss 4\/7 (57%), anemia 4\/7 (57%), diarrhea 1\/7 (14%), DVT1\/7 (14%). Plasma glucagon levels were increased in all patients (range 216.92\u20133155 pg\/mL), and declined after surgery. Imaging studies revealed that four of seven patients had liver metastasis. Six of seven patients received surgical resection, and all of them received somatostatin analogue therapy. Symptoms improved significantly in 6 out of 7 patients. Three of seven patients died of this disease by the time of follow-up. Conclusion: Our data suggest that if persistent NME is associated with DM and high glucagon levels, timely abdominal imaging should be performed to confirm glucagonoma. Once diagnosed, surgery and somatostatin analogues are effective for symptom relief and tumor control.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":263421575,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.21203\/rs.3.rs-1225300\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.21203\/rs.3.rs-1225300\/v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"A determination of the rate of oxidation of metals is beset by many difficulties. If a relatively large quantity of massive metal is used the experiments are very prolonged, owing to the difficulty of oxidising the metal, and it is not easy to maintain the pressure of the oxygen constant during an experiment.* On the other hand, if finely powdered metal, formed from oxide by a reduction process, be used, the local heating during oxidation is so intense that measurements of temperature of the reaction are quite illus'ory. Moreover, the rate of diffusion of the oxygen into the metal is probably a determining factor in the rate of oxidation under such conditions. These difficulties have been surmounted by the use of the method to be described, in which the rates of oxidation of a film of copper about 0 001 mm. thick (and of the reduction of the oxide formed from this copper) have been followed continuously by observations of the changing electrical con\u00ad ductivity of the film. The method can be applied generally to study heterogeneous reactions involving the production from a metal (which must have an easily reducible oxide) of substances of high resistance compared to that of the metal.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249150382,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In answer to the call expressed within the Addis Ababa Action Agenda to mobilise all available resources \u2013 domestic and foreign, public and private \u2013 in support of the Sustainable Development Goals, the Development Co-operation Directorate develops a new work stream on transition finance to explore the evolution and interaction of public (official development assistance and other official flows) and private (foreign direct investments and remittances) sources of finance across the development continuum \u2013 studying multiple stages of development: low income countries, middle income countries, fragile contexts, and different regions of the world. Its ultimate objective is to advise the Development Assistance Committee (DAC) in preparing countries for transition (outlining the optimal financial mix and offering policy recommendations) and in building resilience.This paper introduces the concept of transition finance and initiates research to advise the DAC on its role as a major provider of development assistance among other public and private providers of financing for the 2030 Agenda.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":182314423,"openaccessinfo":{"externalids":{"MAG":"2945324467","ACL":null,"DOI":"10.1787\/2DAD64FB-EN","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To examine the histogenesis and progression of esophageal squamous cell carcinoma, 76 cases of a primary squamous cell carcinoma were reviewed retrospectively, and 16 lesions of squamous cell carcinoma of the esophagus less than 1.0 cm in diameter were studied histopathologically. None of the patients had received radiation therapy preoperatively. Among 16 foci, 13 were intraepithelial carcinomas, and three were restricted to within the mucosa. In two patients with a solitary, minute cancer, there were no associated areas of dysplasia. In 11 patients with multiple primary minute foci, seven contained 14 areas of dysplasia in the esophagus. There was no continuity between the minute foci of carcinoma and areas of dysplasia. These findings are interpreted to mean that dysplasia is a \"subcancerous\" lesion rather than a \"precancerous\" one and that various degrees of lesions such as dysplasia and carcinoma occur multicentrically in the same esophagus. The sequence of dysplasia to carcinoma must be examined using the techniques of molecular biology. Cancer 68:2617\u20132620, 1991.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":27019157,"openaccessinfo":{"externalids":{"MAG":"1995115136","ACL":null,"DOI":"10.1002\/1097-0142(19911215)68:12<2617::AID-CNCR2820681217>3.0.CO;2-U","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes the use of software project development data obtained from industry based projects. It argues the importance of carrying out a preliminary data analysis procedure for software development cost estimation. The paper also presents the limitations of using these industrial data (ISBSG R9 and Bank63 Data) based on the above research. Current state of the research and further work is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73616577,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Most scholarship on the moral dimensions of Tocqueville's analysis of democracy focuses on the doctrine of enlightened self-interest. Surprisingly little has been written about his account of the underlying moral shift that makes this doctrine necessary. Drawing principally on Volume II of DEMOCRACY IN AMERICA, but also on Tocqueville's letters and notes, I unearth his fascinating and compelling account of why modern democratic man loses his admiration for devotion and embraces self-interest. That account begins from individualism, but also includes democratic man's intellectual and aesthetic tastes, his low estimation of his moral capacities, and weakening religious belief. After examining what Tocqueville saw as the causes of the new moral outlook, I consider what he saw as its most profound implications. Departing from recent trends in Tocqueville scholarship, I argue that is in Tocqueville's account of the modern democratic condition as such that he has the most to offer us today.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":145388477,"openaccessinfo":{"externalids":{"MAG":"2142871832","ACL":null,"DOI":"10.1017\/S0003055414000458","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The atomic structure and transition properties of H-like Al embedded in hot and dense plasmas are investigated using modified GRASP2K code. The plasma screening effect on the nucleus is described using the self-consistent field ion sphere model. The effective nuclear potential decreases much more quickly with increasing average free electron density, but increases slightly with increasing electron temperature. The variations of the transition energies, transition probabilities, and oscillator strengths with the free electron density and electron temperature are the same as that of the effective nuclear potential. The results reported in this work agree well with other available theoretical results and are useful for plasma diagnostics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250807871,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1674-1056\/26\/1\/013101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"By using the data from Chinese listed companies in the Shanghai and Shenzhen A-share market for the period 2007 to 2019 and the Report on the Work of the Government, this paper investigates the impact of the local government's economic growth target constraints on enterprise technological innovation and its mechanism. It is found that the local government's economic growth target constraints significantly inhibit enterprise technological innovation, which is more obvious in the samples of SOEs, regulated industries, and enterprises at low marketization levels. The change of government officials' performance appraisal indicators from the quantity to quality of economic growth can alleviate the negative effect. The mechanism effect test indicates that the local government's economic growth target constraints will aggravate enterprise financing constraints and decrease the contribution of R&D investment to enterprise performance, and further inhibit enterprise technological innovation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251281894,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1371\/journal.pone.0272003","PubMedCentral":"9374057","ArXiv":null},"license":"CCBY","url":"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0272003&type=printable","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Monitoring the demographics and movement patterns of mobile marine species underpins appropriate management and conservation strategies. Photographic identification of whale sharks Rhincodon typus based on individual variations in spot patterns is a widely used technique for monitoring of populations, but relies on the untested assumptions that these variations in spot patterns are unique to each shark and can be reliably detected using photo-matching software. This study validated the accuracy of photo-identification technique by manually determining the number of photo-identified individuals showing mismatched genetic profiles created for the individuals using 12 microsatellite markers. Results from 154 photographic and genetic identifications of whale sharks were 100% concordant, showing the uniqueness of spot patterns to each shark and high accuracy of the photo-identification technique. Based on these techniques, we observed an annual resighting rate of approximately 10% at Ningaloo Reef, Western Australia, between 2016 and 2018, showing evidence that variations in spot patterns did not change over a time scale of years. Our study shows that the photographic identification technique provides a reliable means to recognise individuals and monitor whale sharks through time.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":236238155,"openaccessinfo":{"externalids":{"MAG":"3153790314","ACL":null,"DOI":"10.3354\/MEPS13729","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Approximately 10 % of CO2 is emitted from an ordinary Portland cement production. In cement and concrete production, CO2 emissions can be greatly reduced by using Supplementary Cementitious Materials (SCMs). In addition, the microstructure and durability properties of concrete are greatly improved when silica-rich SCMs are used. In this study, Eco-Friendly concrete design was carried out using three different SCMs. Diatomite, ground granulated blast furnace (GGBFS) and fly ash (FA) were used as the SCM in the concrete mixtures. SCMs were used instead of cement at ratios of 5, 10, 15, and 20 wt %. When diatomite was used at the rate of 20 %, the standard consistency water increased 1.7 times as compared to the reference mixture. With the increase in the replacement ratio, the final setting times of the pastes increased. The high active SiO2 content of diatomite shortened the initial setting time and increased the compressive strength. The use of 5 % diatomite reduced the slump value by 57 % as compared to the reference mixture. The slump and Ve-Be tests of GGBFS and FA mixtures showed similar properties to the reference mixture. The 28-day compressive strength of concrete varied between 29.2\u201334.6 MPa. With the increase in the curing time of the concrete mixtures, up to 50 % improvements were observed in the compressive strength. Especially on the 180th day, a compressive strength of 44.1 MPa was obtained in concrete mixtures with a 10 % replacement ratio. While using the FA in the mixtures improved the abrasion properties, the opposite result was observed in the case of the GGBFS. It was observed that the mixtures with 5 % FA showed the closest properties to the reference mixture. As a result, it was determined that SCMs with different properties could be used in environmentally friendly concrete mixtures by up to a 20 % replacement ratio.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":253536412,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.14311\/ap.2022.62.0505","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/ojs.cvut.cz\/ojs\/index.php\/ap\/article\/download\/7773\/6456","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract. It is shown that axiomatic extensions of intuitionistic propositional calculus defining univocally new connectives, including those proposed by Gabbay, are strongly complete with respect to valuations in Heyting algebras with additional operations. In all cases, the double negation of such a connective is equivalent to a formula of intuitionistic calculus. Thus, under the excluded third law it collapses to a classical formula, showing that this condition in Gabbay's definition is redundant. Moreover, such connectives can not be interpreted in all Heyting algebras, unless they are already equivalent to a formula of intuitionistic calculus. These facts relativize to connectives over intermediate logics. In particular, the intermediate logic with values in the chain of length n may be \"completed\" conservatively by adding a single unary connective, so that the expanded system does not allow further axiomatic extensions by new connectives.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":16670786,"openaccessinfo":{"externalids":{"MAG":"2053722013","ACL":null,"DOI":"10.2307\/2694965","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract We consider a dependent lifetime model for systemic risk, whose basic idea was for the first time presented by Freund. This model allows to model cascading effects of defaults for arbitrarily many economic agents. We study in particular the pertaining bivariate copula function. This copula does not have a closed form and does not belong to the class of Archimedean copulas, either.We derive some monotonicity properties of it and show how to use this copula for modelling the cascade effect implicitly contained in observed CDS spreads.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":127783255,"openaccessinfo":{"externalids":{"MAG":"2915201792","ACL":null,"DOI":"10.1515\/demo-2019-0002","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.degruyter.com\/downloadpdf\/journals\/demo\/7\/1\/article-p24.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"SUMMARY Hippocampal complex of the avian brain is one of the most studied brain regions in recent years. This structure is thought to be homologous to mammalian hippocampus and have an important role in spatial memory. Connection patterns between the avian hippocampus and other brain regions strongly support the idea of homology between mammalian and avian hippocampal complexes. Total neuron number of chick hippocampus in different ages was estimated using optical fractionator counting method. Animals were separated into two groups as one day- and seven day-old chicks. The mean total number of nerve cells in the right hippocampi of one day-old and seven day-old chicks was estimated as 783 3 10 + 12 749 and 760 028 + 12 256 respectively. The difference between two groups was not statistically significant (p > 0.05). The mean total volume of hippocampi of chicks was estimated by Cavalieri's principle and it was found to be 2.48 + 0.08 mm3 for one day-old chicks and 2.80 t 0.04 mm3 for seven day-old chicks. The difference between these volume values was statistically significant (p < 0.01). Although the difference in total neuron numbers between two groups was not raised statistically significant level, decreasing cell number with age might be depend on the destruction of unneeded nerve cells with aging. The increased volume in seven day-old group may be associated with enlargement due to several reasons during development.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":85574643,"openaccessinfo":{"externalids":{"MAG":"2143567622","ACL":null,"DOI":"10.1002\/NRC.10035","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The TMI-2 accident resulted in extensive reactor core damage and release of fission products from the fuel. Recent defueling work has confirmed that 30 to 40% (40 to 55 metric tons) of the orginial core material achieved melting temperatures, and an estimated 15 metric tons of molten core material relocated to the lower head region of the reactor vessel. Because of the extensive core damage and core material relocation, the TMI-2 accident provides a unique opportunity to extend our understanding of the physical processes controlling the latter stages of in-vessel core damage progression. The TMI-2 data have provided important insight into the initial core heatup and relocation mechanisms, interaction of the molten core materials with the core support structures and vessel coolant, and the potential localized damage to the instrument assemblies and vessel head. This paper presents the results of recent analytical work to evaluate the long-term thermal response of the lower head.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":135605858,"openaccessinfo":{"externalids":{"MAG":"144131224","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Rice is a crop of growing importance in Zimbabwe but with a production of only 700 metric tonnes. This is because in wetlands it is largely grown by broadcasting of seeds and seedlings; and manual transplanting of seedlings. In practicing the said method however, farmers are exposed to musculosketal disorders as well as back problems due to the repetitive bending as well as the awkward posture needed in performing the task. Though manual transplanting gives uniform crop stand it is quite expensive and requires lot of labour besides involving lot of drudgery. Singh et al., 1985 reported that transplanting takes about 250-300 man hours\/ha which is roughly 25 per cent of the total labour requirement of the crop. The rice production in Zimbabwe has also been very low because the common rice types were affected by the local climatic conditions however in 2014 businessman and farmer struck a deal with renowned Chinese agricultural scientist for National Hybrid Rice Research and Development Centre in Changsha in Hunan Province to start a pilot hybrid rice production exercise that could easily transform Zimbabwe into a major rice growing hub in the SADC region using varieties suitable to local conditions. This paper aims to design an ergonomic rice transplanter suited for the Zimbabwean climate and terrain. The mechanical transplanting of rice has been considered the most promising option, as it saves labour, ensures timely transplanting and attains optimum plant density that contributes to high productivity. Mechanization of rice sector will lead to higher productivity with releasing of work force to other sectors.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":115358111,"openaccessinfo":{"externalids":{"MAG":"2795371847","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Conventionally, sputtering deposition of thin films requires a low base pressure (high vacuum) to minimize influences of residual gases. Here, a high base pressure (low vacuum) was used, which can reduce significantly the overall processing time. Aluminum nitride ( AlN ) was selected as a model system of dielectric nitrides. All the analyses revealed that the obtained films under a low vacuum environment within specific processing windows exhibited characteristics similar to those of high-vacuum made AlN films. Such a low vacuum deposition technique takes advantages of kinetically favorable formation of the nitride films and hence, has great potentials in many more technological applications.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":135985186,"openaccessinfo":{"externalids":{"MAG":"2097309810","ACL":null,"DOI":"10.1111\/J.1744-7402.2012.02790.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"THERE has been an increasing trend toward measuring insulation resistance of high-voltage machines and cables at or above their rated voltage by the use of direct current. The advantage of high voltage lies in its ability to detect leakage paths which do not occur at lower voltages.1 D-c tests are advantageous because of the elimination of capacitance-current effects. Since the resistances measured are usually quite high \u2014 of the order of megohms \u2014 if high-voltage alternating current is used to test insulation, even small load capacitances offer impedances low enough to mask the insulation-resistance effect.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":51634592,"openaccessinfo":{"externalids":{"MAG":"2051220890","ACL":null,"DOI":"10.1109\/T-AIEE.1945.5059111","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Maize is a dynamic cereal of world's agriculture community and is grown both in spring and autumn seasons in Pakistan. In case of spring sowing (February sowing) both pistillate and staminate flowers face high temperature stress and ultimately results in poor seed setting because of increased silk dryness and pollen desiccation. Maize accessions were identified on the basis of their performance at high temperature stress against the indicators like cell membrane thermostability (CMT), leaf temperature (LT), pollen viability %age (PV%), pollen production (PP), pollen germination %age (PG%), pollen grain size (PGS), pollen moisture contents %age (PMC%), and pollen tube length (PTL). Significant differences were observed among the genotypes for high temperature tolerance related indicators which provided wide range of option for selection and opportunity to improve tolerance level against high temperature stress. Principle component analysis (PCA) proved PV%, PP, PG% and PTL as best physiological standards for evaluation of germplasm against high temperature stress. Genotypes viz. B-321, EV-323, POP-209, B-308, B-316, F-127, B-236, EV340, F-143 and SAWAN-3 showed high level of variability and performed well under heat stress. Genotypes showing high level of adaptability in response to imposed stress could be a good genetic source carrying wide diversity of genes responsible for high temperature tolerance and could be used in breeding program to breed for high temperature tolerance in maize.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":6518297,"openaccessinfo":{"externalids":{"MAG":"2167506540","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The success of solid-organ transplantation was made possible by recognizing that destruction of the graft is caused by an alloimmune-mediated process. For the past decade, immunosuppressive protocols have used a combination of drugs that significantly decreased the rate of acute organ rejection. Despite advances in surgical and medical care of recipients of solid-organ transplants, long-term graft survival and patient survival have not improved during the past 2 decades. Current immunosuppression protocols include a combination of calcineurin inhibitors, such as tacrolimus, and antiproliferative agents (most commonly mycophenolate mofetil), with or without different dosing regimens of corticosteroids. Mammalian target of rapamycin inhibitors were introduced to be used in combination with cyclosporine-based therapy, but they did not gain much acceptance because of their adverse event profile. Belatacept, a costimulatory inhibitor, is currently being studied in different regimens in an effort to replace the use of calcineurin inhibitors to induce tolerance and to improve long-term outcomes. Induction therapy is now being used in more than 90% of kidney transplants and more than 50% cases of other solid-organ transplantation such as lung, heart, and intestinal transplants. As a result of these combination immunosuppressive (IS) therapy protocols, not only the incidence but also the intensity of episodes of acute rejection have decreased markedly, and at present 1-year graft and patient survival is almost 98% for kidney transplant recipients and approximately greater than 80% for heart and lung transplants. Evolving concepts include the use of donor-derived bone marrow mesenchymal cells to induce tolerance, to minimize the use of maintenance IS agents, and to prevent the development of adverse events associated with long-term use of maintenance IS therapy.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":23359136,"openaccessinfo":{"externalids":{"MAG":"2074235967","ACL":null,"DOI":"10.1615\/CRITREVEUKARYOTGENEEXPR.2015011421","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND OBJECTIVES\nFaecal calprotectin is predictive of clinical relapse in inflammatory bowel disease and ultrasound is sensitive in detecting its post-surgical recurrence. However, no data regarding the role of calprotectin in predicting post-surgical recurrence in asymptomatic Crohn's disease are available. The aim of this study was to prospectively evaluate the role of calprotectin as a predictive marker for one year post-surgical endoscopic recurrence in comparison with ultrasound in patients with asymptomatic Crohn's disease.\n\n\nMATERIAL AND METHODS\nWe consecutively enlisted 50 patients who had undergone a resection for Crohn's disease. Faecal calprotectin was analysed and ultrasound were performed at the third month, and a colonoscopy after one year. The sensitivity and specificity of these two techniques were evaluated using endoscopic findings as a golden standard. A Receiver Operator Curve (ROC) curve was plotted, in order to identify the best-cut off value for calprotectin.\n\n\nRESULTS\n39 out of 50 patients were evaluated by performing a colonoscopy after one year; 19 patients had an endoscopic recurrence after one year. Calprotectin sensitivity and specificity were calculated for 5 different cut-off values; the best cut-off value for calprotectin sensitivity (63%) and specificity (75%) was > 200 mg\/L. The US sensitivity and specificity at the third month were 26% and 90% respectively.\n\n\nCONCLUSIONS\nWhen performed three months after surgery ultrasound is more specific than calprotectin in predicting endoscopic recurrence. Faecal calprotectin at a dosage > 200 mg\/L seems to have a better sensitivity than ultrasound. Values of calprotectin > 200 mg can be an indication to colonoscopy in the group of patients with negative ultrasound in order to detect early recurrence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12798202,"openaccessinfo":{"externalids":{"MAG":"2147917065","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We report the properties of the interacting S0 galaxy NGC 5195 (M51B), revealed in a pixel analysis using the Hubble Space Telescope\/Advanced Camera for Surveys images in the F435W, F555W, and F814W (BVI) bands. We analyze the pixel color\u2013magnitude diagram (pCMD) of NGC 5195, focusing on the properties of its red and blue pixel sequences and the difference from the pCMD of NGC 5194 (M51A; the spiral galaxy interacting with NGC 5195). The red pixel sequence of NGC 5195 is redder than that of NGC 5194, which corresponds to the difference in the dust optical depth of 2 < \u0394\u03c4V < 4 at fixed age and metallicity. The blue pixel sequence of NGC 5195 is very weak and spatially corresponds to the tidal bridge between the two interacting galaxies. This implies that the blue pixel sequence is not an ordinary feature in the pCMD of an early-type galaxy, but that it is a transient feature of star formation caused by the galaxy\u2013galaxy interaction. We also find a difference in the shapes of the red pixel sequences on the pixel color\u2013color diagrams (pCCDs) of NGC 5194 and NGC 5195. We investigate the spatial distributions of the pCCD-based pixel stellar populations. The young population fraction in the tidal bridge area is larger than that in other areas by a factor >15. Along the tidal bridge, young populations seem to be clumped particularly at the middle point of the bridge. On the other hand, the dusty population shows a relatively wide distribution between the tidal bridge and the center of NGC 5195.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":119204874,"openaccessinfo":{"externalids":{"MAG":"2115002738","ACL":null,"DOI":"10.1088\/0004-637X\/754\/2\/80","PubMedCentral":null,"ArXiv":"1205.4777"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Although emissions trading is embraced as a means to curb carbon emissions and to incentivize the use of renewable energy, it is also heavily contested on ethical grounds. We will assess the main fundamental objections and possible counterarguments. Although we sympathize with some of these arguments, we argue that they are unpersuasive when an emissions trading system is well designed: emissions should be accounted 'upstream,' on the production rather than the consumer level. Moreover, allowances should be auctioned, and regulatory measures (such as an escalating tax on additional allowances) could instigate the right kind of behavior towards the environment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":156079244,"openaccessinfo":{"externalids":{"MAG":"2415707819","ACL":null,"DOI":"10.1080\/21550085.2016.1173282","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/pure-oai.bham.ac.uk\/ws\/files\/36625900\/2016_Dirix_et_al._ET_ethics_.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Sustainable development refers to the ability to satisfy the needs of the present generation without impinging on future generations capability to supply demands. The worlds present population reached 5 billion on July 11 1987 and is symbolized in this paper as \"child 5- billion\". The population is increasing at a rate of 245000 people\/day which results in an increased demand for resources. This rate is 4 times greater for less developed countries than for more developed countries. Limitations are present in a sustainable environment and include food air and water. More specifically increased population demands for increased food production could result in the degradation of cropland by over-cultivation over-irrigation and over-grazing. Degradation of the cropland increased demand for fuelwood and potential urbanization would lead to deforestation and soil erosion. With increased food production water consumption would also rise which could result in waterlogged soil inept sewage systems and untreated polluted water. Furthermore air pollution could also pose a problem and could contribute to the greenhouse effect. Concerns for global environmental management should include utilization of limited resources chemical waste and dangers to the biosphere. Conservation of natural resources at a national level would contribute to sustainable development in 3rd World countries. 4 suggestions offer optimism for future. These include the demand for environmental precautions increased awareness of sustainable development at a local level for 3rd World nations 3rd World leadership in the global sustainable development operation and employment of population policies for 3rd World countries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":131479780,"openaccessinfo":{"externalids":{"MAG":"2279918809","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Atrial fibrillation (AF) is related to a very complex local electrical activity reflected in the rich morphology of intracardiac electrograms. The link between electrogram complexity and efficacy of the catheter ablation is unclear. We test the hypothesis that the Kolmogorov complexity of a single atrial bipolar electrogram recorded during AF within the coronary sinus (CS) at the beginning of the catheter ablation may predict AF termination directly after pulmonary vein isolation (PVI). The study population consisted of 26 patients for whom 30 s baseline electrograms were recorded. In all cases PVI was performed. If AF persisted after PVI, ablation was extended beyond PVs. Kolmogorov complexity estimated by Lempel\u2013Ziv complexity and the block decomposition method was calculated and compared with other measures: Shannon entropy, AF cycle length, dominant frequency, regularity, organization index, electrogram fractionation, sample entropy and wave morphology similarity index. A 5 s window length was chosen as optimal in calculations. There was a significant difference in Kolmogorov complexity between patients with AF termination directly after PVI compared to patients undergoing additional ablation (p < 0.01). No such difference was seen for remaining complexity parameters. Kolmogorov complexity of CS electrograms measured at baseline before PVI can predict self-termination of AF directly after PVI.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":208269119,"openaccessinfo":{"externalids":{"MAG":"2978885354","ACL":null,"DOI":"10.3390\/e21100970","PubMedCentral":"7514301","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1099-4300\/21\/10\/970\/pdf?version=1571396785","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Various gonioscopic lenses were tested in the operating room for viewing the size and foot placement of the Choyce Mark VIII intraocular lens. The Tennant and the Worst fiber optic devices were fairly adequate. The Thorpe surgical gonioscope was the easiest to handle, and provided a good view with the operating microscope.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21198913,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: To investigate the prognostic value of 18F\u2013fluorodeoxyglucose positron emission tomography\/computed tomography (18F-FDG PET\/CT) in esophagus squamous cell carcinoma (ESCC), PET\/CT imaging characteristics were explored in the present study.Methods: Baseline PET\/CT and clinical characteristics were collected in 125 patients with ESCC treated with radical radiotherapy from 2007\u20132016. The maximum standardized uptake value (SUVmax) of the primary gross tumour (SUVmax-T) and metastatic lymph node (SUVmax-N) were separately measured using X-tile. Overall survival (OS) and progression free survival (PFS) were estimated according to the Kaplan\u2013Meier method. A multivariate Cox model was used to establish the independent prognostic factors.Results: The gross tumours presented higher 18F-FDG uptake than normal tissues with a median SUVmax-T of 12.5. The OS and PFS did not show significant differences between patients with SUVmax-T \u2265 12.5 and those with SUVmax-T <12.5 (P>0.05). However, patients with SUVmax-N \u2265 11 had a significantly worse OS and PFS than those with SUVmax-N <11 (P<0.05). A weak correlation was observed in SUVmax-T and SUVmax-N. The OS and PFS of patients with PET-negative LNs was significantly better than those with PET-positive LNs. However, the OS and PFS of patients with one or two PET-positive LNs were not significantly better than those with more than two PET-positive LNs. In the univariate analysis, cT stage, positive or negative lymph nodes on the PET-CT image and the SUVmax-N were established as significant prognostic factors for both OS and PFS. In multivariate analysis, SUVmax-N was proved to be an independent predictor for OS and PFS.Conclusions: SUVmax-N, but not SUVmax-T, is an independent prognostic indicator for patients with ESCC.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":234627191,"openaccessinfo":{"externalids":{"MAG":"3150308810","ACL":null,"DOI":"10.21203\/rs.3.rs-92219\/v1","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.researchsquare.com\/article\/rs-92219\/v1.pdf?c=1602871905000","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The taxonomic affiliation (in the systematisation of viruses, and biological domains) of known peptides and proteins of biomineralization (silicateins, silaffins, silacidins and silicase) and their primary structure homologues were analyzed (methods in silico; using Uniprot database). The total number of known peptides and proteins of biosilicification was counted. The data of the quantitative distribution of the detected homologues found in nature are presented. The similarity of the primary structures of silaffins, silacidins, silicateins, silicase, and their homologues was 21\u201394%, 45\u201398%, 39\u201350%, and 28\u201340%, respectively. These homologues are found in many organisms, from the Protista to the higher plants and animals, including humans, as well as in bacteria and extracellular agents, and they perform a variety of biological functions, such as biologically controlled mineralisation. The provisional classification of these biomineralization proteins is presented. The interrelation of the origin of the first organic polymers and biomineralization is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17845362,"openaccessinfo":{"externalids":{"MAG":"2070605876","ACL":null,"DOI":"10.1155\/2013\/397278","PubMedCentral":"3697285","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/bmri\/2013\/397278.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Primary pulmonary arterial hypertension is a rare lethal disease that typically presents radiographically with enlarged central pulmonary arteries, pruning of the peripheral vasculature, and cardiomegaly but clear lung fields. Although it is a disease of unknown etiology, primary PAH has been associated with anorexigen use. We present a case of pulmonary arterial hypertension in a woman with a history of fenfluramine and phentermine use who presented with diffuse micronodules on computed tomography scan. Lung biopsy confirmed the micronodules were radiographic manifestations of extensive diffuse plexogenic arterial lesions. This report represents an unusual radiographic presentation of anorexigen related pulmonary arterial hypertension, and to our knowledge, the first case reported as presenting with diffuse micronodules on high resolution computed tomography scan.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21216109,"openaccessinfo":{"externalids":{"MAG":"2112675236","ACL":null,"DOI":"10.1080\/10408370490888442","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We present predictions for the gluon-fusion Higgs p_{T} spectrum at third resummed and fixed order (N^{3}LL^{'}+N^{3}LO) including fiducial cuts as required by experimental measurements at the Large Hadron Collider. Integrating the spectrum, we predict for the first time the total fiducial cross section to third order (N^{3}LO) and improved by resummation. The N^{3}LO correction is enhanced by cut-induced logarithmic effects and is not reproduced by the inclusive N^{3}LO correction times a lower-order acceptance. These are the highest-order predictions of their kind achieved so far at a hadron collider.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":236924270,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1103\/PhysRevLett.127.072001","PubMedCentral":null,"ArXiv":"2102.08039"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract In this study, we performed method validations for the Abaxis Piccolo Xpress assays for total protein, albumin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, calcium, creatinine, urea nitrogen, and glucose compared with the Roche Cobas c501 analyzer. The validation included linear reportable range, imprecision, and assessment of accuracy and bias by method crossover. Although some biases between the methods were observed, these could be reconciled by adjustments to the normal reference ranges. Overall, we found that these assays performed at an accepted level for clinical use.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79620717,"openaccessinfo":{"externalids":{"MAG":"2618110969","ACL":null,"DOI":"10.1097\/POC.0000000000000136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Medical signal processing is often used to detect diseases. Segmentation, filtering, categorization are basic operations in this field. In this study; a two-band quadrature mirror orthogonal filter bank structure is used to emphasize and extract signals like QRS wave from electrocardiography, evoked potential from electroencephalography signal. One branch of the filter bank is adopted to filter out a target signal. This is done by minimizing error energy at the output of the filter bank system. The approach is run and tested for a QRS signal and a synthetic evoked potential signal. The common orthogonal wavelet filters (Daubechies, Symlet, Coiflet) and designed filter are compared in terms of mean squared error (MSE). The designed filter attains the target signal with the minimum MSE and outperforms common classical wavelet filters.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":49654372,"openaccessinfo":{"externalids":{"MAG":"2828288785","ACL":null,"DOI":"10.1109\/SIU.2018.8404160","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Bombay has a teeming and mobile yet comparatively invisible population of approximately 600 male prostitutes who ply their trade on and from Chowpatty beach. These men aged 12-50 years masturbate and\/or perform fellatio for male clients in exchange for financial reward ranging from US$0.75 - $2. Unprotected penetrative anal sex also takes place though it is generally not acknowledged by the prostitutes. These men and their clients are therefore in great need of information and access to condoms for the practice of safer sex. Both self- and social denial of the practice of anal sex must however be overcome. To this end Bombay Dost the 1st openly gay organization in India distributes condoms and information to gay men on railway platforms and in public toilets and parks. These efforts are unfortunately not welcomed by the prostitutes of Chowpatty beach for fear that acceptance of the intervention would imply their practice of anal sex and a more substantial degree of homosexuality within their subpopulation. Recruiting and training men as health educators from their ranks may be a viable effective promotion approach. Any interventions must also understand the friendly and supportive yet competitive relationships within this community.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":74718647,"openaccessinfo":{"externalids":{"MAG":"2275391162","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The rapid growth of social media and user-generated contents (UGC) has provided a rich source of potentially relevant data. The problems arise on how to summarize those data to understand and transforming it into information. Twitter as one of the most popular social networking and micro-blogging service can be analyzed in terms of content produced with sentiment analysis. On the other hand, some types of networks can also be constructed to analyze the social network structure and network properties. This research intended to combine those content and structural approaches into hybrid approach for identifies social opinion polarization, this is in the form of conversation network. Sentiment analysis used to determine public sentiment, and social network analysis used to analyze the structure of the network, detecting communities and influential actors in the network. Using this hybrid approach, we have comprehensive understanding about social opinion polarization. As case study, we present real social opinion polarization about reclamation issue in Indonesia.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":32241466,"openaccessinfo":{"externalids":{"MAG":"2765563892","ACL":null,"DOI":"10.1109\/ICOICT.2017.8074650","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently, a novel concept of a non-probabilistic novelty detection measure, based on a multi-scale quantification of unusually large learning efforts of machine learning systems, was introduced as learning entropy (LE). The key finding with LE is that the learning effort of learning systems is quantifiable as a novelty measure for each individually observed data point of otherwise complex dynamic systems, while the model accuracy is not a necessary requirement for novelty detection. This brief paper extends the explanation of LE from the point of an informatics approach towards a cognitive (learning-based) information measure emphasizing the distinction from Shannon's concept of probabilistic information. Fundamental derivations of learning entropy and of its practical estimations are recalled and further extended. The potentials, limitations, and, thus, the current challenges of LE are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":68245102,"openaccessinfo":{"externalids":{"MAG":"2911969372","ACL":null,"DOI":"10.3390\/e21020166","PubMedCentral":"7514648","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1099-4300\/21\/2\/166\/pdf?version=1550834027","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract Synchrotron X-ray powder diffraction study of brucite, Mg(OH)2, was carried out in a diamond anvil cell with an imaging plate detector from 0.6 to 18.0 GPa at room temperature using the angular- dispersive technique on beamline BL-18C at the Photon Factory, KEK, Japan. Using Rietveld analysis, unit-cell parameters as well as atomic positions of the O atoms in brucite have been successfully refined, taking into account the effects of preferred orientation. Variation of the c\/a ratio with pressure indicates that the compression mechanism changes around 10 GPa, above which the compression behavior is isotropic. Based on the changes of the refined atomic positions of the O atoms with pressure, we conclude that the shortening of the interlayer distance controls compression below 10 GPa, whereas above this pressure compression of the oxygen sublattice is the dominant mechanism. Results of the structural refinements also suggest that the MgO6 octahedral regularity initially approaches a regular configuration with pressure, which then remains unchanged above 10 GPa.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100462321,"openaccessinfo":{"externalids":{"MAG":"2411035335","ACL":null,"DOI":"10.2138\/am-2000-5-615","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: Early studies have shown that micropulse transscleral cyclophotocoagulation (MP-TSCPC) might be an effective and safe treatment option for lowering intraocular pressure (IOP). These studies were, however, somewhat limited, in particular by their retrospective nature and the length of follow-up. Therefore, we assessed the efficacy and safety of this novel treatment in a large cohort for up to 4 years. Methods: We performed a prospective cohort study, including all patients who were treated with MP-TSCPC since November 2017. The primary outcome was a reduction of IOP and the number of IOP-lowering medications. Results: The mean \u00b1 standard deviation baseline IOP and number of IOP-lowering medications were 26.6 \u00b1 10.8 mmHg and 3.3 \u00b1 1.3. IOP was reduced by 8.2 \u00b1 7.9 (31.8% reduction), 6.9 \u00b1 8.7 (28.1% reduction), and 7.1 \u00b1 8.4 (30.2% reduction) mmHg after 6, 12, and 24 months, respectively (p < 0.001). The mean postoperative number of IOP-lowering medications was significantly reduced after 6 months by 0.6 \u00b1 1.5 (p = 0.002) but was not significantly different after 12 or 24 months. Oral acetazolamide was significantly reduced from 28 (29%) eyes before treatment, to 9 (9%) at the last follow-up visit (p < 0.001). No major complications were observed after treatment. Conclusions: MP-TSCPC is a safe and effective treatment option for lowering IOP, but only reduced IOP-lowering medications in the first 6 months after treatment. However, MP-TSCPC is especially effective in getting patients off oral IOP-lowering drugs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249804186,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/jcm11123447","PubMedCentral":"9224545","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2077-0383\/11\/12\/3447\/pdf?version=1655352666","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"PURPOSE OF REVIEW\nIn a conventional IVF cycle, final oocyte maturation and ovulation is triggered with a bolus of hCG, followed by progesterone-based luteal support that spans several weeks if pregnancy is achieved. This article summarizes several approaches of the exogenous progesterone-free luteal support in IVF.\n\n\nRECENT FINDINGS\nTriggering ovulation with GnRH agonist may serve as an alternative to hCG, with well established advantages. In addition, the luteal phase can be individualized in order to achieve a more physiologic hormonal milieu, and a more patient friendly treatment, alleviating the burden of a lengthy exogenous progesterone therapy.\n\n\nSUMMARY\nGnRH agonist trigger followed by a 'freeze all' policy is undoubtedly the best approach towards the 'OHSS-free clinic'. If fresh embryo transfer is considered well tolerated after GnRH agonist trigger, rescue of the corpora lutea by LH activity supplementation is mandatory. Herein we discuss the different approaches of corpus luteum rescue.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":230666401,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/GCO.0000000000000682","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this work, some new 2-[(3,4-dichlorophenyl)methyl]-1H-benzimidazole derivatives containing different five-membered heterocycles like 1,3,4-oxadiazole, 1,3,4-triazole, and 1,3,4- thiadiazole moieties were designed and efficiently synthesized starting from 2-[(3,4-dichlorophenyl) methyl]-1H-benzimidazole. The products were screened for their in vitro antioxidant and \u03b1-glucosidase inhibitory activities. Among the synthesized compounds, some of them showed efficient \u03b1-glucosidase inhibition with IC50 values ranging between 16.05 \u00b1 0.94 and 77.02 \u00b1 1.12 \u03bcg\/mL when they were compared with the standard \u03b1-glucosidase inhibitor acarbose having IC50 value 12.04 \u00b1 0.68 \u03bcg\/mL. The antioxidant activity of all products was screened by using various in vitro antioxidant assays, including CUPric Reducing Antioxidant Capacity (CUPRAC) and Ferric Reducing Antioxidant Power (FRAP) assays. Also, the radical scavenging activities of the products were assayed by using the ABTS method.\nmethod.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":216198842,"openaccessinfo":{"externalids":{"MAG":"3014206207","ACL":null,"DOI":"10.2174\/1570178617666200330130024","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The objective of this investigation is to compare acute genitourinary (GU) and gastrointestinal (GI) toxicity results of radiotherapy to localized fields delivered using intensity-modulated radiotherapy (IMRT) versus conventional radiotherapy (ConvRT). The records of 481 consecutive prostate cancer patients receiving RT to localized fields at a single institution were reviewed; 108 received IMRT and 373 received ConvRT. Acute GU and GI toxicity, as defined by the Radiation Therapy Oncology Group (RTOG) grading system, were compared using the chi-square test. Ordered logit regression analyses were performed using all major disease and treatment factors as covariates. Acute GU grade 0, 1, 2, 3, and 4 toxicity rates were 23%, 40%, 34%, 3%, and 0%, respectively, in the IMRT cohort and 31%, 37%, 30%, 1%, and 1%, respectively, in the ConvRT cohort - these rates were not significantly different (p=0.118). Acute GI grade 0, 1, 2, 3, and 4 toxicity rates were 42%, 37%, 22%, 0%, and 0%, respectively, in the IMRT cohort and 33%, 32%, 35%, 0%, and 0%, respectively, in the ConvRT cohort - this lower toxicity in the IMRT group was significant (p=0.013). The regression analyses showed that only IMRT use (p=0.046) predicted reduction in acute GI toxicity but no factors correlated with acute GU toxicity rate. In conclusion, in our retrospective single-institution analysis, IMRT was not associated with reduction of acute GU toxicity but was associated with a reduction of acute GI toxicity over ConvRT in the treatment of prostate cancer to localized fields.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":32734183,"openaccessinfo":{"externalids":{"MAG":"2329384085","ACL":null,"DOI":"10.1177\/153303460700600102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Pathomorphology of structural elements of the liquor circulation system and its three components (liquor production, circulation, and outflow) in gunshot wounds of the head is discussed. Their role in the development of traumatic diseases of the brain and its complications is analyzed. Classification and characteristics of the main pathomorphological variants of liquor circulation disorders in gunshot wounds of the skull and brain are presented.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2398675,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A study was conducted to investigate the influence of planting methods and tuber weight on growth and yield of local yam cultivars obtained by the minisett technique from white yam (D. rotundata) in Gabon. Trials were carried out in 2014 and 2015 at the experimental ground of the Higher National Institute of Agronomy and Biotechnology, under natural conditions of lightness, temperature and relative humidity. Twentyfour weeks old mini tubers obtained from local cultivar MVA of D. rotundata were harvested, weighed and categorized (40-80g; 100-150g; 200-300g), and three planting methods (horizontal, oblique and vertical),arranged in ridges constituted the main factors. The experiment was laid out in Randomized Completely Block Design with eighteen treatments and two replications. Data pertaining to sprouting were recorded for 30, 60, 90 and 180 DAP, for tuber length (cm), tuber weight (Kg) and number of tubers per plant 270 DAP. Significant differences among tuber weight in all variables tested were observed. The larger tubers had better sprouting ability than the rest of the tuber weight. The methods of planting had no effects on yield and its components but they affect the depth and spread of tubers. Vertical planting produced deeper but more compactly arranged tubers while horizontal planting produced tubers which were shallower but more widespread. Slanting was intermediate for both depth and spread. The number and weight of tubers obtained from mini tubers planted out according to slanting method were significantly different (P< 0.05) from other planting methods. The production of seedlings from mini tuber is an improvement of traditional production of seed yam. Mini tubers must have at least 100-300 g and they should be planted slanting or vertically.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":44527759,"openaccessinfo":{"externalids":{"MAG":"2580396887","ACL":null,"DOI":"10.14303\/IRJAS.2016.025","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract:This article analyzes women's own emergency preparedness courses within voluntary defense training Finland as a site of \"vernacular security\". The article introduces a subcategory of vernacular security, \"vernacular preparedness\" to illustrate what woman citizens familiar with voluntary defense training make of security and defense policies where they are seen as key actors in producing grass-roots security, both as private citizens and when serving state institutions. The interviewees, both participants and course leaders, situate themselves within a gendered division of security labor characterized by male conscription. This produces a civic ideal of a psychologically resilient, altruistically caring, and physically capable civilian whose preparedness covers concerns ranging from emergencies and disasters to potential wartime efforts.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":236611375,"openaccessinfo":{"externalids":{"MAG":"3160806630","ACL":null,"DOI":"10.1093\/SP\/JXAB012","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Volatile degassing is a major process driving volcanic eruptions. Therefore, a full understanding of mechanisms ranging from bubble nucleation, growth, coalescence, to magma fragmentation is required. We have simulated magma degassing during ascent in the volcanic conduit by depressurizing hydrated haplogranite melts in high-pressure and high-temperature optical cells (a hydrothermal diamond-anvil cell and an internally heated pressure vessel fitted with sapphire windows). This allowed the whole process of bubble nucleation, growth, and coalescence to be directly observed in situ through images captured from the recording videos. Bubble nucleation pressures, number densities, growth laws, and characteristics of coalescence were estimated as a function of melt water content, decompression rate, and temperature. Melt\/vapor surface tension during bubble nucleation and coalescence was calculated. Our data show good agreement with those previously obtained in classical vessels. Methodological improvements are proposed for the experimental simulation of magma degassing in volcanic conduits.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":130324205,"openaccessinfo":{"externalids":{"MAG":"2323868956","ACL":null,"DOI":"10.2138\/am.2011.3546","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"North American forests and forest management institutions are experiencing a wide range of significant ecological disturbances and socioeconomic changes, which point to the need for enhanced resilience. A critical capacity for resilience in institutions is strategic foresight. This article reports on a project of the North American Forest Commission to use Futures Research to enhance the resilience of forest management institutions in North America. The Aspirational Futures Method was used to develop four alternative scenarios for the future of North American forests and forestry agencies: (1) an extrapolation of current trends into the expectable future titled Stressed Forests, (2) a scenario of growing desperation titled Megadisturbances Call for Military Intervention, (3) a high aspiration future titled High Tech Transformation and Cooperation, and (4) an alternative pathway to a highly preferable future titled Cultural Transformation Embraces Indigenous Values. These scenarios will be used in discussions and futures exercises with forestry leaders to develop foresight and assure that plans are responsive to the challenges and opportunities ahead.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":169493609,"openaccessinfo":{"externalids":{"MAG":"2792086008","ACL":null,"DOI":"10.1177\/1946756718757751","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A great number of Cenozoic petroleum basins have been discovered in the northern continental margin of the South China Sea.Two of them,the Qiongdongnan Basin and the Pearl River Mouth Basin are located in the deepwater area of the region.Recently medium and large petroleum discoveries have been obtained in the southern deepwater area of the Pearl River Mouth Basin.It verifies that favorable petroleum geological conditions occur in the deepwater area.Having similar tectonic and depositional evolutionary history with the Pearl River Mouth Basin,the southern deepwater area of the Qiongdongnan Basin should have the same potential to form medium to large gas reservoirs.It,therefore,has become a necessity to study this area in details.The accumulation of high resolution seismic data in recent years has made it possible to understand more about the structural pattern of the deepwater area of the Qiongdongnan Basin.In this regard,the Huaguang Sag was selected as a case for study.Our study reveals that there are four types of extensional structures in the area,namely graben,half graban,terraced garaben and terraced half graben,formed in two stages,corresponding to the two regional structural evaluation stages in the region.There is an obvious double-layer vertical architecture in the sag,including the rifting lower layer and the subsiding upper layer,and four units have been recognized in the sag according to the structural pattern,namely the western sag,eastern sag,middle horst and the southern slope.The distribution of Paleogene deposits or the lower layer is obviously controlled by rifting.The tectonic activities in Neogene or the upper layer were rather weak.There is little tectonic deformation.The double layer architecture has provided an excellent combination for hydrocarbon accumulation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":133434532,"openaccessinfo":{"externalids":{"MAG":"2390774311","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Norman Eugene Smith died June 14, 1996, in Lafayette, Louisiana, following a determined six-month battle with cancer. Norman was born April 11, 1930, in Malden, Missouri, the fifth of seven children of the late Charles S. Smith and the former Trella Victoria Sorrells. He graduated from Risco High School in Risco, Missouri, and then from the University of Missouri with a Bachelor of Science degree in agricultural engineering. After serving in the U.S. Air Force from 1951 to 1953, Norman returned to the University of Missouri where he earned a master9s degree in geology in 1955. At the time of his death Norman was a member of the development board for the Geology Department at the University of Missouri. While serving in the Air Force in Lake Charles, Louisiana, Norman married the former Barbara Jean Sutton on August 31, 1953. He is survived by Jean and their two children, Vicki Ann Smith of Lafayette, Louisiana and Charles Johnson Smith of Malden, Missouri and Lafayette, Louisiana. He is also survived by two brothers, two sisters, one grandson, and two step grandsons. Following his graduation from the University of Missouri in 1955, Norman accepted a position on the geological staff of Continental Oil Company. After a short stay in Morgan City, Louisiana, Norman and his family were transferred to Houston, Texas, and then to Lafayette, Louisiana, in 1961, where he lived and worked for the remainder of his career. In 1976, Norman opened an office for Jones O9Brien, Inc. in Lafayette as manager of their South Louisiana Operations. In 1981, he became vice president and exploration manager of Federated Energy Corporation, and in 1986, Norman formed his own company, Lafayette Exploration and Development Company, where he remained as chief executive officer until his death. Norman9s career in petroleum geology covered the full range of exploration and development in both the offshore and onshore areas of the Gulf Coast. Smitty, as he was widely known among his many friends and acquaintances around the oil center in Lafayette, was a man of many interests. Professionally, he was a \"hands on\" geologist who possessed many firmly held beliefs and opinions that were developed as a result of long hours of detailed work with the correlations and structural-depositional complexities of Gulf Coast geology. He was a man not easily swayed from a personal opinion and liked nothing more than a good debate on the nuances of a particular technical point to demonstrate his view to interested colleagues. Smitty was also a very successful geologist. When judged on the basis of the huge reserves that were discovered and developed as a direct result of his programs, he is ranked as one of the more accomplished exploration geologists of our time. Smitty was also a \"man of the times.\" Although he came out of the era of paper and pencil geology where all data were meticulously recorded, interpreted, and erased by hand, he was heavily invested in computer technology and was firmly dedicated to the concept that the geologic wave of the future would come through computers. On a more personal level, Smitty had a wide range of interests in all sports and was generous in his support of local collegiate sports, especially football and basketball. He was an avid hunter and became proficient in many sports, including golf, bowling, and softball at various times. In his later years, Smitty became interested in antique automobiles and had assembled an impressive collection at the time of his death. Smitty was a member and strong supporter of AAPG as well as numerous other professional organizations throughout his career. He was an active Mason and had been active in many local civic organizations. Norman Smith was a good and generous man. With his passing, the oil and gas industry lost a good soldier, his family lost a strong husband and father, and I lost a good friend. He is sorely missed by us all.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":132508373,"openaccessinfo":{"externalids":{"MAG":"2412500335","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Allergic uveitis caused by streptococci are recognized as flowing from a pesthole, the most frequent of them being considered the erythematous and the pultaceous angina. The characteristic of these angina is that they may go unnoticed, the frequency of asymptomatic forms being five times higher than those of symptomatic forms. Since the onset of angina until the early signs of ocular manifestations there is an open interval where there have been no clinical manifestations for approximately two weeks. In the cases presented further on, the nature of streptococcal uveitis represents all immunoallergic phenomena induced by the streptococcus at the uveal level. A significant proportion of the patients presenting endogenous uveitis, despite of the classical performed treatment (non-steroidal, steroidal and immunosuppressants anti-inflammatory drugs) attain to relapsing forms (30-50%) with powerful complications that respond to late and\/or inefficient treatment, managing to burn down the inflammatory phenomena, sacrificing the ocular function. The life of these patients turns out to be full of suffering, prolonged hospitalization, and some of them will count themselves among those with a visual handicap.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26697380,"openaccessinfo":{"externalids":{"MAG":"2081954076","ACL":null,"DOI":"10.2478\/arsm-2014-0013","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.sciendo.com\/pdf\/10.2478\/arsm-2014-0013","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Thermal comfort depends on heat exchanges of the body by conduction evapo-transpiration and convection to the air, and radiation to and from surrounding surfaces. Usual ways of sizing heating and cooling systems are based on homogeneous temperature in the room, and these devices are located using common knowledge. Such a design method is not well adapted to radiant panels, since a significant part of the heating and cooling is performed by thermal radiation, and one of the advantages of such panels is that they allow temperature differences in the room. RADIACONF is a computer design tool allowing drawing comfort maps in rooms heated or cooled with various devices, including radiant panels. It is based on the Fanger equation but also includes the discomfort specific to radiant temperature anisotropies. For the time being, this software is in French. Therefore, the paper is also in French.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":106488000,"openaccessinfo":{"externalids":{"MAG":"812386191","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We investigate second-harmonic generation from one-dimensional gratings in Mos2 monolayer flakes structured by focused ion beam milling, and observe diffraction orders due to nonlinear diffraction from the periodic structure. \u00a9 2019 The Author(s)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":164278498,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1364\/cleo_qels.2019.fw3b.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nanosized SnO2 based sensors are widely used for gas sensing applications because of their low operating temperature and high surface area. SnO2 films are conventionally deposited by chemical vapor deposition, evaporation, sol-gel and sputtering which are very expensive, time consuming processes and complex. In contrast, electrophoretic deposition (EPD) is simple, cost effective which makes it possible to fabricate reliable porous coatings. The aim of this work is to deposit porous and homogenous SnO2 films by using EPD and to investigate the surface morphology of the films for gas sensor production. In this study nanosized SnO2 (60nm) particles were used in non-aqueous mediums with and without iodine to prepare stabilized EPD suspension. Homogeneous and porous film layers were processed and analyzed at various time and voltages. The results showed that highly porous, crack free and homogeneous SnO2 films on Pt coated alumina substrate were achieved for 5 and 15 seconds at 100V EPD parameters. Optimum sintering between the SnO2 nanoparticles was observed at 500oC. Deposited film thickness of 5 \u03bcm was measured by scanning electron microscopy. According to initial results, EPD deposited SnO2 films showed high sensitivity to liquified petroleum gas (LPG) at various gas concentration and operation temperature.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11764470,"openaccessinfo":{"externalids":{"MAG":"2065981263","ACL":null,"DOI":"10.1109\/ICSENS.2012.6411500","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Au-substituted Al - Cu - Fe icosahedral phases, , were prepared by melt spinning. EDS data showed that Cu as well as Al atoms are effectively substituted for with Au. The hypercubic lattice parameter of as-quenched samples slowly increases with x, while phonon- and phason-type disorders are not affected by Au substitution. Experimental structure factors for `sum' lines were used to derive an average radius of the atomic hypersurfaces. Comparison of experimental versus calculated ratios of structure factors for different models yielded information about the Au distribution over the icosahedral sites. It was inferred that a fraction of the gold shapes its Al surrounding in a -type configuration. Evidence was found for d - sp hybridization of Au - Al bonds, on the basis of the `white-line' area at the Au absorption edge.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":98085966,"openaccessinfo":{"externalids":{"MAG":"2077948595","ACL":null,"DOI":"10.1088\/0953-8984\/9\/36\/003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract A dimeric copper(II) complex, bis{(2-[1-(aminoethylimino)ethyl]-phenoxo}-di-\u03bc1,1-azido-dicopper(II), [Cu2(L)2(\u03bc2-1,1-N3)2] (1) [L\u2009=\u20092-[1-(aminoethylimino)ethyl]-phenoxo ion], has been isolated using a self-assembly reaction using a 1:1:1 molar ratio of Cu(NO3)2\u00b73H2O, HL and NaN3 in methanol at room temperature and characterized through X-ray diffraction analysis and spectroscopic studies. X-ray structural analysis reveals that 1 consists of two distinct dinuclear molecular units, where each copper(II) center in the individual dinuclear unit adopts a distorted square pyramidal geometry with a CuN4O chromophore ligated through a tridentate (NNO) Schiff base and two N atoms of two different bridging azides in \u00b51,1-mode. Two Cu(II) centers are linked through double \u00b52-1,1-N3 bridges to form the dinuclear unit [Cu2(L)2(\u03bc2-1,1-N3)2]. In the crystalline state, the dinuclear units in 1 are associated through weak intermolecular N-H\u22efO hydrogen bonds to afford a 2-D sheet structure viewed along the crystallographic a-axis. The small magnitude of the antiferromagnetic interaction (J = \u20130.45\u2009cm\u22121) is a result of the long Cu\u00b7\u00b7\u00b7Cu separation (3.205(2) \u00c5). The catalytic efficacy of 1 was studied in a series of solvents for the epoxidation of alkenes using tert-butyl-hydroperoxide (TBHP) as an efficient oxidant under mild conditions. Graphic abstract","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226337937,"openaccessinfo":{"externalids":{"MAG":"3093664353","ACL":null,"DOI":"10.1080\/00958972.2020.1836360","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A carbene-oxazoline catalyst 1 proved to be an effective catalyst for reduction of an enol ether that the literature suggested could not be hydrogenated effectively by P,N-Ir catalysts. Thus, a series of ester and alcohol substrates were hydrogenated using catalyst 1. Good to excellent enantioselectivities and high conversions were obtained.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":95425741,"openaccessinfo":{"externalids":{"MAG":"2014550962","ACL":null,"DOI":"10.1002\/ADSC.200700546","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nWe examined the relation of individual-level perceived discrimination to mortality in a biracial, population-based sample.\n\n\nMETHODS\nParticipants were 4154 older adults from the Chicago Health and Aging Project who underwent up to 2 interviews over 4.5 years. Perceived discrimination was measured at baseline, and vital status was obtained at each follow-up and verified through the National Death Index.\n\n\nRESULTS\nDuring follow-up, 1166 deaths occurred. Participants reporting more perceived discrimination had a higher relative risk of death (hazard ratio [HR]= 1.05; 95% confidence interval [CI]=1.01, 1.09). This association was independent of differences in negative affect or chronic illness and appeared to be stronger among Whites than among Blacks (Whites: HR=1.12; 95% CI=1.04, 1.20; Blacks: HR=1.03; 95% CI=0.99, 1.07). Secondary analyses revealed that the relation to mortality was related to discriminatory experiences of a more demeaning nature and that racial differences were no longer significant when the sample was restricted to respondents interviewed by someone of the same race.\n\n\nCONCLUSIONS\nPerceived discrimination was associated with increased mortality risk in a general population of older adults. The results suggest that subjective experience of interpersonal mistreatment is toxic in old age. This study adds to a growing literature documenting discrimination as an important social determinant of health.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8915653,"openaccessinfo":{"externalids":{"MAG":"2066683678","ACL":null,"DOI":"10.2105\/AJPH.2007.114397","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Knowledge management is an important issue that is often brought up in the modern organization. Implementation of knowledge management is not only about selection of the right application, but rather to spread a culture of sharing knowledge among members of the organization itself. One of the important aspects on implementations Knowledge management is the process of knowledge capture and knowledge sharing. This process must be supported by adequate application and easily learned by all parties. Wikimedia, since the very beginning, has been regarded as one of the practical applications that can support collaborative writing and interaction among users. Wikimedia also can be considered as one of the practical applications for the process of capturing knowledge and knowledge sharing. Ease of installation and customization process made Wikimedia as one popular application adopted by the organization. University, as a source of knowledge, should facilitate the sharing of information and knowledge in the local community or to the general public. However, in many universities, especially in Indonesia, does not yet provide adequate medium for sharing knowledge. It is considered as an opportunity to develop a prototype of media dissemination of information in the form of an online encyclopedia for Widyatama University. Requirement identification for media collaboration is done with the PIECES approach, and the result is realized by build the prototype of Widyapedia based on Wiki.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":53833773,"openaccessinfo":{"externalids":{"MAG":"135801658","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Few contemporary philosophers discuss the ways in which the emotion of shame may be gendered. This paper addresses this situation, examining Gabriele Taylor's (1985 and 1995) account of genuine vs. false shame. 1 argue that, by attending to the social pressures placed on many women to conform to a certain vision of femininity, an analysis of the shame to which women may be prone shows that Taylor's account of shame remains incomplete.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":144103078,"openaccessinfo":{"externalids":{"MAG":"2022421748","ACL":null,"DOI":"10.1111\/j.1527-2001.2003.tb00820.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A general method for the efficient difluoromethylation of alcohols using commercially available TMSCF2 Br (TMS=trimethylsilyl) as a unique and practical difluorocarbene source is developed. This method allows primary, secondary, and even tertiary alkyl difluoromethyl ethers to be synthesized under weakly basic or acidic conditions. The reaction mainly proceeds through the direct interaction between a neutral alcohol and difluorocarbene, which is different from the difluoromethylation of phenols. Moreover, alcohols containing other moieties that are also reactive toward difluorocarbene can be transformed divergently by using TMSCF2 Br. This research not only solves the synthetic problem of difluorocarbene-mediated difluoromethylation of alcohols, it also provides new insights into the different reaction mechanisms of alcohol difluoromethylation and phenol difluoromethylation with difluorocarbene species.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12994814,"openaccessinfo":{"externalids":{"MAG":"2587533365","ACL":null,"DOI":"10.1002\/anie.201611823","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Substitution models of evolution describe the process of genetic variation through fixed mutations and constitute the basis of the evolutionary analysis at the molecular level. Almost 40 years after the development of first substitution models, highly sophisticated, and data-specific substitution models continue emerging with the aim of better mimicking real evolutionary processes. Here I describe current trends in substitution models of DNA, codon and amino acid sequence evolution, including advantages and pitfalls of the most popular models. The perspective concludes that despite the large number of currently available substitution models, further research is required for more realistic modeling, especially for DNA coding and amino acid data. Additionally, the development of more accurate complex models should be coupled with new implementations and improvements of methods and frameworks for substitution model selection and downstream evolutionary analysis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10488749,"openaccessinfo":{"externalids":{"MAG":"2186750819","ACL":null,"DOI":"10.3389\/fgene.2015.00319","PubMedCentral":"4620419","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2015.00319\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"At the beginning of the article the author gives a short survey of all important past forms of co-operation of the Balkan countries. Within the dense network of various forms for establishment of co-operation in the Balkans the latest one was the Adriatic-Ionian Initiative (AII) presented three years ago. In the author's opinion the Initiative resulted from the attempt of Italy to expand its influence to this region as well as its aspiration to make a counter-balance to Germany, which obviously exerts the greatest influence of all EU states in this part of Europe. The author presents the development of the Initiative since it was established in 2000 up to 2003. He expounds the chronology of AII creation, analysing the documents it has adopted so far, its basic principles and objectives, organisational structure, forms of cooperation and particularly the work of the round (working) tables as the most important form through which its activities are carried out. In a separate part the author has described the initiative that preceded AII and it was the Forum of Cities on the Adriatic and Ionian Seas. Today, the Forum is only a part of AII. The Initiative is headed by the AII Council; it meets at least once a year and at the beginning it was composed of ministers of foreign affairs of member states. Today, the Council also embraces speakers, and the last meeting was also attended by heads of states or governments of AII member states. Acting of the Initiative has been made operational through the work of the following working tables: education and inter-university cooperation; security and cooperation in reducing illegal activities; the round table for culture, working tables for environmental protection, sustainable development and resources preservation; the round table for economy, tourism, medium- and small-size entrepreneurship and the round table for maritime business and traffic. Analysing the work of the round tables the author points to the fact that member states make efforts to establish as close as possible the cooperation in the most important economic, security, cultural and educational fields, endeavouring to establish and improve not only the multilateral but the bilateral cooperation, too. The author is also of the opinion that cooperation within AII can be one of the opportunities to accelerate the accession to the European Union of these AII member countries that have before them a long way to join the European integration institutions. The last part of the article analyses the participation of representatives from Serbia and Montenegro in AII as well as the opportunities the Initiative offers to our state to achieve development and integration into EU. Our country has a favourable opportunity to display through this and some other initiatives its will to cooperate, this particularly including the fields of security, education and economy. The author points to the fact that Serbia and Montenegro insufficiently attaches importance to the Initiative since there is a lack of common and coordinated acting of participants from our state. As the author says at the end of the paper, greater attention should be devoted to the Initiative as a means to accede to EU and other European integrations, because the ultimate goal is to establish peace, stability and prosperity in the region and Europe as a whole.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":108566944,"openaccessinfo":{"externalids":{"MAG":"1992243480","ACL":null,"DOI":"10.2298\/medjp0304413k","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.doiserbia.nb.rs\/ft.aspx?id=0025-85550304413K","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this article is to argue that the joy of musical experience through Samulnori with abdominal breathing plays significant role in improving liver cirrhosis. Samulnori is one of the most popular programs in music education in Korea. It helps fully express the player's emotions. The data are based on interview and observation drawn from field experience. Interviewee has continued to practice in charity performances of Samulnori in nursing homes once a month since 2011. Through learning and practicing, musical experience of Samulnori produces a large measure of physical health and psychological satisfaction. This article concludes in-depth interview, a patient with liver cirrhosis that has shown gradual improvement through Samulnori with abdominal breathing from 2011 to 2014.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54892701,"openaccessinfo":{"externalids":{"MAG":"2273950524","ACL":null,"DOI":"10.5667\/TANG.2015.0020","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The method of circular dichroism was used to evaluate the conformation parameters of the secondary structure of the molecule of isolated influenza virus hemagglutinin H3. Comparison of the data obtained with the similar known parameters for hemagglutinin H2 has shown significant differences in the secondary structure, which are, probably, responsible, (at the level of a higher structural organization) for the variations in the antigenic specificity of hemagglutinins H2 and H3. Temperature and pH stability of alpha-spiral areas of the hemagglutinin H3 molecule was studied, and the direct participation of aromatic amino acid residues in formation of the alpha-spiral areas was shown. The native state of the hemagglutinin alpha-spiral areas may serve as a factor determining potential hemagglutination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28412834,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Compositional variations of Central Andean subduction-related igneous rocks reflect the plate-tectonic evolution of this active continental margin through time and space. In order to address the effect on magmatism of changing subduction geometry and crustal evolution of the upper continental plate during the Andean orogeny, we compiled more than 1500 major- and trace-element data points, and 650 Sr-, 610 Nd-, and 570 Pb-isotopic analyses of Mesozoic-Cenozoic (190\u20130 Ma) magmatic rocks in southern Peru and northern Chile (Central Andean orocline), mostly from new data and the literature. This data set documents compositional variations of magmas since Jurassic time, with a focus on the Neogene period, when major crustal thickening developed and its influence on magma composition was most pronounced. We relate the observed variations in Sr\/Y, La\/Yb, La\/Sm, Sm\/Yb, and Dy\/Yb ratios, as well as in Sr-, Nd-, and Pb-isotopic ratios, to the crustal structure and evolution of the Central Andean orocline. In particular, the evolution of Dy\/Yb and Sm\/Yb ratios, which track the presence of the higher-pressure minerals amphibole and garnet, respectively, in the lower crust, documents that crustal thickness has grown through time. Spatial variations in trace elements and isotopic ratios further suggest that crustal domains of distinct composition and age have influenced magma composition through some assimilation. The crustal input in Quaternary magmas is quantified to have been between 7% and 18% by simple two-components mixing. When comparing our geochemical data set to the geological record of uplift and crustal thickening, we observe a correlation between the composition of magmatic rocks and the progression of Andean orogeny. In particular, our results support the interpretation that major crustal thickening and uplift were initiated in the mid-Oligocene (30 Ma) and that crustal thickness has kept increasing until present day. Our data do not support delamination as a general cause for major late Miocene uplift in the Central Andes and instead favor continued crustal thickening.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":128833878,"openaccessinfo":{"externalids":{"MAG":"2074674283","ACL":null,"DOI":"10.1130\/B26538.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Perinatal asphyxia is the main cause of morbidity and mortality in the new-borns and in the infants. During delivery the risk of severe asphyxia is high not only in pre-term infants but also in those at term. A correct assistance during the first minutes of life is crucial for the outcome of the asphyxiated babies. The interventions to perform are few and quite simple but they must be performed carefully. There are some standardised steps in the correct assistance of the new-borns in the delivery room: A)--airways gentle cleaning. B)--breathing, maintain a good ventilation with manual assistance avoiding the use of oxygen. Oxygen is toxic not only for preterm infants but also for babies at term. C)--cardiac activity, check in order to maintain a good blood pressure. Permanent brain damages are related not only to the length and the severity of asphyxia but mainly to the cardiac activity and to the circulation., D)--drugs: only few drugs are seldom necessary for rescutation of the new-borns in the delivery room--beta-mimetics, Na-bicarbonate, surfactant--and they must be used carefully. The time is another critical point to prevent permanent damages, in the severe asphyxia only few minutes and for this reason it is mandatory the presence in delivery room of a person with very good experience in the newborn resuscitation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21766534,"openaccessinfo":{"externalids":{"MAG":"98949970","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Factors affecting the growth of the firms are usually divided into three groups. These are \nfactors related firms, factors related entrepreneurial, and industry \u2013 related factors. Gender \ndiversity is a entrepreneurial \u2013 based factor. In this study we investigated the effect of gender \ndiversity on the growth of the firms. So far, in empirical studies being male or female \nentrepreneurs are found to be an impact on firm performance. It appears from studies that \nsurvival probabilities of firms founded by women are lower than those firms founded by male \nentrepreneurs and firms which established by women entrepreneurs grow more slowly than \nfirms established by male entrepreneurs was concluded. \nTo measure the impact of gender diversity on growth performance of firms we used data of \nbusiness incubation firms in Turkey. Face to face interviews were conducted with companies \noperating in the 12 Business Incubators around the Turkey. The sample of this study is firms \nstill active in business incubators, firms are closing left and was graduated from Business \nIncubators. \nIn the application part of the study we investigated Tobit Regression Model to measure the \neffect of the gender diversity on the growth of the firms. Based on findings, gender diversity \nwas concluded to be effective on the growth of the firms in a meaningful way. \nKeywords: Firm Growth, gender diversity, entrepreneurs, firm survival, incubators.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":166350413,"openaccessinfo":{"externalids":{"MAG":"1799363075","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A review of the research shows that critical thinking is a more inclusive construct than intelligence, going beyond what general cognitive ability can account for. For instance, critical thinking can more completely account for many everyday outcomes, such as how thinkers reject false conspiracy theories, paranormal and pseudoscientific claims, psychological misconceptions, and other unsubstantiated claims. Deficiencies in the components of critical thinking (in specific reasoning skills, dispositions, and relevant knowledge) contribute to unsubstantiated belief endorsement in ways that go beyond what standardized intelligence tests test. Specifically, people who endorse unsubstantiated claims less tend to show better critical thinking skills, possess more relevant knowledge, and are more disposed to think critically. They tend to be more scientifically skeptical and possess a more rational\u2013analytic cognitive style, while those who accept unsubstantiated claims more tend to be more cynical and adopt a more intuitive\u2013experiential cognitive style. These findings suggest that for a fuller understanding of unsubstantiated beliefs, researchers and instructors should also assess specific reasoning skills, relevant knowledge, and dispositions which go beyond what intelligence tests test.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-10":1,"unknown":2}},"corpusid":264808461,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/jintelligence11110207","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The G protein G(s)alpha is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver G(s)-signaling pathways by developing mice with liver-specific G(s)alpha deficiency (LGsKO mice). LGsKO mice had increased liver weight and glycogen content and reduced adiposity, whereas survival, body weight, food intake, and metabolic rates at ambient temperature were unaffected. LGsKO mice had increased glucose tolerance with both increased glucose-stimulated insulin secretion and increased insulin sensitivity in liver and muscle. Fed LGsKO mice were hypoglycemic and hypoinsulinemic, with low expression of hepatic gluconeogenic enzymes and PPARgamma coactivator-1. However, LGsKO mice maintained normal fasting glucose and insulin levels, probably due to prolonged breakdown of glycogen stores and possibly increased extrahepatic gluconeogenesis. Lipid metabolism was unaffected in fed LGsKO mice, but fasted LGsKO mice had increased lipogenic and reduced lipid oxidation gene expression in liver and increased serum triglyceride and FFA levels. LGsKO mice had very high serum glucagon and glucagon-like peptide-1 levels and pancreatic alpha cell hyperplasia, probably secondary to hepatic glucagon resistance and\/or chronic hypoglycemia. Our results define novel roles for hepatic G(s)-signaling pathways in glucose and lipid regulation, which may prove useful in designing new therapeutic targets for diabetes and obesity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25630872,"openaccessinfo":{"externalids":{"MAG":"2149343591","ACL":null,"DOI":"10.1172\/JCI24196","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We have fabricated a series of textured silicon surfaces decorated by square arrays of pillars whose radius and pitch can be adjusted independently. These surfaces possessed a hydrophobic\/superhydrophobic property after silanization. The dynamic behavior of water droplets impacting these structured surfaces was examined using a high-speed camera. Experimental results validated that the remaining liquid film on the pillars' tops gave rise to a wet surface instead of a dry surface as the water droplet began to recede away from the textured surfaces. Also, experimental results demonstrated that the difference in the contact time was subjected to the solid fraction referred to as the ratio of the actual area contacting with the liquid to its projected area on the textured surface. Because the mechanism by which the residual liquid film emerges on the pillars' tops can essentially be ascribed to the pinch-off of the liquid threads, we further addressed the changes in the contact time in terms of the characteristic time of pinch-off of an imaginary liquid cylinder whose radius is related to the solid fraction and the maximum contact area. The match of the theoretical analysis and the experimental results substantiates the assumption aforementioned.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":9456004,"openaccessinfo":{"externalids":{"MAG":"1985494660","ACL":null,"DOI":"10.1021\/la903603z","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Objective: The \naim of this study was to analyze the NP\/OP S. \npneumoniae serotype distribution and potential vaccine coverage in Costa \nRican children with Otitis Media (OM) before the introduction of PCV-7 in the National Immunization Program \n(NIP). Methods: Between 2002 and \n2006, NP and OP samples were obtained from 641 children from 6 to 79 months of \nage, at the time of OM diagnosis. S. \npneumoniae serotyping and antimicrobial susceptibility were performed. Results: 386 S. pneumoniae isolates were recovered. The most common S. pneumoniae serotypes (ST) were: ST \n6B, ST 14, ST 19F. \nPenicillin non-susceptibility was observed among 57% of the isolates obtained \nfrom children Conclusions: S. pneumoniae was isolated from the NP \nand\/or OP in the majority (59%) of studied children with OM. At a statistical \nsignificant level, only serotype 3 was more frequently isolated among children \n>24 months of age. Antibiotic non-susceptibility and MDR were significantly \nhigher in children","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":37634539,"openaccessinfo":{"externalids":{"MAG":"2050649324","ACL":null,"DOI":"10.4236\/WJV.2013.32007","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nParaesophageal hernias are rare and, when associated with symptoms, the risk of complications increases, becoming a surgical emergency.\n\n\nCLINICAL CASE\nWe report a case of a 53 year-old female with 3 weeks of clinical evolution including abdominal pain, nausea and occasional vomiting; 24 h prior to admission she presented intestinal occlusion. Radiographic and tomographic findings showed a paraesophageal hernia, requiring exploratory laparotomy, which demonstrated a 9 cm paraesophageal diaphragmatic defect with a hernia sac containing transverse colon, omentum, fundus and body of the stomach (this last one presented ~60% of necrosis), performing nonanatomic gastrectomy and simple diaphragmatic reconstruction. The patient had a complicated postoperative period requiring two additional surgeries attempting to correct gastrectomy dehiscence and ending with a third procedure for cervical esophagostomy and Witzel jejunostomy.\n\n\nCONCLUSIONS\nElective repair is recommended in all patients with asymptomatic paraesophageal hernia in order to avoid possible complications. The approach method is dependent on the surgeon's experience and the conditions of the hernia and involved structures at the time of diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":2632984,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Here we report on a nanoscale circular dichroism (CD) imaging for a two-dimensional chiral pair of nanostructures to elucidate the relationship between nanoscale chirality and CD activity. The chiral pair exhibited local ellipticity as high as 42 degrees in the CD signal at the center, with signals of both handedness coexisting in one nanostructure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263058840,"openaccessinfo":{"externalids":{"MAG":"2056758683","ACL":null,"DOI":"10.1039\/c3cp50854d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"There is fundamentally no difference between a value added tax (VAT), and a retail sales tax (RST) when it comes to collecting the tax on cross-border sales. If (under a VAT) a seller is allowed to \"zero-rate\" cross-border sales, or if (under a RST) a seller is exempt from collecting the tax on cross-border sales, the critical enforcement question is exactly the same \u2013 how does the system assure that the buyer will self-assess (and pay) the tax? The simple answer is that the tax administration audits. The more complicated answer notes that the effectiveness of the audit (by the destination jurisdiction) depends heavily on its ability to secure transactional data from the origin jurisdiction. Without a good information exchange mechanism this audit is difficult. The EU's data-sharing mechanism involves recapitulative statements by origin state sellers and a VAT Information Exchange System (VIES) that shares this information with the destination state. There is a technology-intensive proposal to do the same among the US states, the Use Tax Reciprocity (UTR) system. The EU's recapitulative statement\/VIES network is a classic Black Swan, a program characterized by extraordinary cost overruns, extreme schedule delays, and dramatic shortfalls in realized benefits. Black Swans have an average cost overrun of 200%, and an average schedule overrun of 70%. The UTR has the same problems. Program management professionals from the Harvard, Berkeley and Oxford business schools would suggest that the UTR promoters suffer from \"Black Swan blindness.\" They need to ask if this major IT project: (1) Can absorb the hit if the project goes over budget by 400%? (2) Can survive if only 25% to 50% of the projected benefits are realized? (3) Can take the hit if 15% of the medium-sized IT projects (secondary projects related to the main project) are also over budget by 200%? Many of the URT's difficulties can be identified through a \"reference class forecasting\" study.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1}},"corpusid":168122943,"openaccessinfo":{"externalids":{"MAG":"2253650438","ACL":null,"DOI":"10.2139\/SSRN.2009425","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background and Purpose\u2014 Tissue-type plasminogen activator (tPA) is the only drug approved for the acute treatment of ischemic stroke but with two faces in the disease: beneficial fibrinolysis in the vasculature and damaging effects on the neurovascular unit and brain parenchyma. To improve this profile, we developed a novel strategy, relying on antibodies targeting the proneurotoxic effects of tPA. Methods\u2014 After production and characterization of antibodies (&agr;ATD-NR1) that specifically prevent the interaction of tPA with the ATD-NR1 of N-methyl-D-aspartate receptors, we have evaluated their efficacy in a model of murine thromboembolic stroke with or without recombinant tPA-induced reperfusion, coupled to MRI, near-infrared fluorescence imaging, and behavior assessments. Results\u2014 In vitro, &agr;ATD-NR1 prevented the proexcitotoxic effect of tPA without altering N-methyl-D-aspartate-induced neurotransmission. In vivo, after a single administration alone or with late recombinant tPA-induced thrombolysis, antibodies dramatically reduced brain injuries and blood\u2013brain barrier leakage, thus improving long-term neurological outcome. Conclusions\u2014 Our strategy limits ischemic damages and extends the therapeutic window of tPA-driven thrombolysis. Thus, the prospect of this immunotherapy is an extension of the range of treatable patients.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153031,"openaccessinfo":{"externalids":{"MAG":"2006581420","ACL":null,"DOI":"10.1161\/STROKEAHA.110.606293","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In a short communication printed in this Journal (vol. xxxvii. p. 137) I described a large boulder of hornblende picrite which I found near Pen-y-Carnisiog in the autumn of 1880. Last summer I had an opportunity of spending an afternoon upon the western coast of Anglesey, and made use of it to examine the interesting section to the south of Porth Nobla. I did not, however, neglect to look out for boulders, as I thought it not impossible that I might meet with some more picrite. In this I succeeded beyond my expectations, and now lay the results before the Society, together with some remarks on the microscopic structure of the specimens collected. After quitting the railway at Ty Croes Station, I walked a short distance along the road to the south-west, and then turned up a field-way leading past a small farm called Bryn Gwyn. A short quarter of a mile from it a boulder (No. I.), perhaps roughly trimmed, has been utilized as the capstone of a gate-post. It measures 2 3\/4 \u00d7 2 \u00d7 1 1\/4 feet. A small fragment projected, which I was able to detach for examination without injury to the stone. The next (No. II.) was a well-rounded boulder lying on the sandy shore at Perth Nobla. This had a rather greener matrix than those which I had previously seen: and the porphyritic hornblende or augite crystals were not quite so large. It measured about 2 feet each way, and rose about 1 foot above the","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":128921570,"openaccessinfo":{"externalids":{"MAG":"2129773732","ACL":null,"DOI":"10.1144\/GSL.JGS.1883.039.01-04.20","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the late 1800s, in the Ukrainian town of Ekaterinoslav, Hannah, a woman only in her forties, began suffering from progressive memory loss and eventually became unable to care for herself. What seemed an isolated incident remained unexplained at her death in the 1890s. Years later, Hannah's grandson Charles, a physician, spurred by his painful observations that many members of his family were all suffering from the same disease, began charting the family's medical history over five generations. In 1985, when this pedigree-one of the most extensive of its kind-fortuitously fell into the caring hands of neurologist Dr. Dan Pollen, Hannah's family would find themselves immersed in one of the most enduring scientific searches of the century-the quest for the Alzheimer's disease genes. In Hannah's Heirs, Dr. Pollen himself tells the compelling story of Hannah's family and their monumental contributions to the fight against Alzheimer's. We are there in 1985 when Charles presents Pollen with three decades' worth of family medical records as well as data from studies that even Pollen and his associates did not then know existed. We see the selfless acts of Hannah's descendants in their struggle against Alzheimer's: great-grandson Jeff's conviction that after his death his brain be used for all possible research; great-granddaughter Lucy's decision to overcome her dread of flying in order to reach the research centre for testing; and Charles's continued research in the face of a disease that might strike him at any moment. Pollen sets this gripping story within the larger context of the efforts to solve the mysteries of Alzheimer's. He presents the foundations of modern genetic research, from Gregor Mendel's classic discovery of genes, to Alois Alzheimer's work on the brains of presenile dementia victims, to Watson and Crick's double helix model for the structure of DNA. He narrates the latter-twentieth century efforts of scientists to systematically narrow down the causes of Alzheimer's: Carlton Gajdusek's research excluding slow viruses as a cause of Alzheimer's; and the stunning success of Peter St. George- Hyslop's group in Toronto in September 1992 in decisively linking Alzheimer's in Hannah's family to chromosome 14. At the same time, Pollen offers a penetrating look at the ongoing conflicts involved in scientific research, revealing how intense competition for prestige and funding has driven some scientists to hoard precious cell lines. These practices have impeded efforts to discover both the causes and the treatment of Alzheimer's in the shortest possible time. As Hannah's great-grandson Ben has written, \"This is a story that had to be told. Aspirations were transcendent, but because it involved people it could not be told without tears.\" Written by a physician-scientist who has been a central figure in the study of familial Alzheimer's, Hannah's Heirs is an inspiring portrait of the efforts of a courageous family to confront and overcome a \"personal biological Holocaust,\" and an encouraging look at the advances in science that have created the basis for the eventual understanding and treatment of Alzheimer's disease. And for those who have seen the horrors of Alzheimer's, for all who fear the aging process that will take its toll on everyone, here is an inside look at one of the great medical detective stories of our time.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":142560028,"openaccessinfo":{"externalids":{"MAG":"1585340258","ACL":null,"DOI":"10.5860\/choice.31-2150","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/europepmc.org\/articles\/pmc1918055?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Background : Residual pleural thickening is frequently seen following treatment for tuberculous pleurisy, and pleural decortication is performed occasionally in patients with severe residual pleural thickening. However, predictive factors for the development of residual pleural thickening are uncertain at the initial diagnosis of the tuberculous pleurisy. Therefore, the purpose of this study was to identify the associated factors for residual pleural thickening at initial diagnosis. Methods : We separated 63 patients diagnosed as tuberculous pleurisy into two groups; group 1 consisted of patients without residual pleural thickening and group 2 comprised patients with residual pleural thickening at the end of tuberculous pleurisy treatment. We analyzed the clinical characteristics, radiological findings, pleural biopsy and characteristics of pleural fluid between group 1 and group 2. Results : The study population and clinical symptoms of the two groups were not significantly different and the duration of symptoms before treatment and the peripheral WBC were similar between the two groups. The presence of pulmonary tuberculosis, pleural fluid loculation or the amount of pleural effusion sid not differ significantly between the two groups. The incidence of positive AFB staining(group 1 : 8%, group 2 : 38%) and granuloma(group 1 : 30%, group 2: 62%)on pleural biopsy specimens was significantly higher in group 2 than in group 1. Pleural fluid WBC and differential count, adenosine deaminase level, pH, protein level or glucose level did not differ between the two groups. However, group 2 had higher LDH levels () than group 1 (, p","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":76640786,"openaccessinfo":{"externalids":{"MAG":"2340659797","ACL":null,"DOI":"10.4046\/TRD.2001.50.5.607","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper is part of a large study on the Social Protection in Rural India and China. In this paper, we attempt at a critical appraisal of the historical development and experience of social security initiatives in Kerala, India. We situate the development experience of Kerala in a conceptual framework of participatory development, which we interpret in a broad context of organization and mobilization of people at specific junctures of historical progress of a society. Thus participatory development, in our view is participation in the progressive process of realization of human rights and thus in development; that is, public action, with an effective public demand and a wiling public supply, conditioned by the legitimate function of the state. It is also attempted to categorize the on-going social security schemes according to the definitional framework of our study, that is, in terms of the definitional division of social security into basic and contingent social security.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":154873127,"openaccessinfo":{"externalids":{"MAG":"2116369969","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Smart polymer-based theranostic agents often have the problem of a low drug release rate and it is difficult for them to reach the site of brain tumors for magnetic resonance imaging (MRI). To synthesize a theranostic agent for brain tumor MRI with a high drug release rate, paramagnetic, pH and temperature-sensitive polymeric particles (PPPs) are synthesized using a simplified processes in this work. These dually sensitive polymeric particles show negligible cytotoxicity against HeLa and glioma (C6) cells. The obtained polymeric particles can effectively be loaded with the anticancer drug doxorubicin (DOX). In vitro drug release measurements exhibit retarded release profiles when subjected to varying pH or temperature. Moreover, DOX-loaded PPPs exhibit obvious antitumor properties for C6 cells. The percentage of cumulative DOX release is higher than 95% when both pH and temperature are changed. The T1-weighted relaxivity values at 3 T are 12.41 mM\u22121 s\u22121 (pH = 6.3) and 10.75 mM\u22121 s\u22121 (pH = 7.4). In vivo MRI reveals that the PPPs can be effectively imaged in brain tumors (gliomas). These results indicate that the PPPs have great potential in diagnosing and treating glioma.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":97769659,"openaccessinfo":{"externalids":{"MAG":"2145393002","ACL":null,"DOI":"10.1039\/C5RA16199A","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"AIM\nTo investigate the marital status and fertility in long-term survivors of high-grade osteosarcoma.\n\n\nPATIENTS AND METHODS\nWe surveyed the marital rate (number of married persons\/total number of persons) in 46 long-term survivors of osteosarcoma who were treated in our hospital between 1976 and 2002. In addition, we examined the fertility rate (number of persons having offspring\/number of married persons) in 29 married patients. The participants were divided into 2 groups: one group (MC) in which moderate-dose chemotherapy was performed between 1976 and 1986; and another group (IC) in which intensive-dose chemotherapy was performed between 1987 and 2002. In each group, the fertility rate was investigated. As controls, we surveyed the marital and fertility rates in 52 siblings of the patients.\n\n\nRESULTS\nIn the patients, the marital rate was 63.0% (29\/46). There was no significant difference in the marital rate between the patients and their siblings. In the patients, the overall fertility rate was 58.6% (17\/29). The fertility rate of male patients in the IC group (16.7%, 1\/6) was significantly lower than that of their male siblings (76.5%, 13\/17) (p = 0.018).\n\n\nCONCLUSION\nThese results suggest that recently intensified chemotherapy for osteosarcoma affects fertility in long-term male survivors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10763172,"openaccessinfo":{"externalids":{"MAG":"2186147770","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Trichloroanisole (TCA) in wine results in a sensory defect called \"cork taint\", a significant problem for the wine industry. Wines can become contaminated by TCA absorption from the atmosphere through contaminated wood barrels, cork stoppers, and wood pallets. Air-depleted solvent-impregnated (ADSI) cork powder (CP) was used to mitigate TCA in wines. The ADSI CP (0.25 g\/L) removed 91% of TCA (6 ng\/L levels), resulting in an olfactory activity value of 0.14. A Freundlich isotherm described ADSI CP TCA adsorption with irreversible adsorption and a KF = 33.37. ADSI CP application had no significant impact on the phenolic profile and chromatic characteristics of red wine. Using headspace sampling with re-equilibration, an average reduction in the volatile abundance of 29 \u00b1 15%, 31 \u00b1 19%, and 37 \u00b1 24% was observed for the 0.10, 0.25, and 0.50 g\/L ADSI CP, respectively. The alkyl esters and acids were the most affected. The impact observed was much lower when using headspace sampling without re-equilibration. Isoamyl acetate, ethyl hexanoate, ethyl hexanoate, and ethyl decanoate abundances were not significantly different from the control wine and 0.25 g\/L ADSI CP application. Thus, ADSI CP can be a new sustainable fining agent to remove this \"off-flavor\" from wine, with a reduced impact on the wine characteristics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250940522,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/molecules27144614","PubMedCentral":"9322358","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1420-3049\/27\/14\/4614\/pdf?version=1658296612","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Although much progess has been made in the detection and characterization of homocytotropic antibodies, identification of the factors which control their synthesis remains to be determined. To assess the influence of different adjuvants on anti-dinitrophenol (DNP) immunoglobulin E (IgE) antibody responses, rabbits were immunized with adjuvant plus homologous albumin (HRA) heavily substituted with DNP (DNP30-HRA). This antigen in rabbits has a B cell-reactive determinant (DNP) and weak non-B cell-reactive determinants (new antigenic determinants) which sensitize rabbits for delayed-type hypersensitivity reactions to DNP30-HRA. It was postulated that the anti-DNP IgE response to DNP30-HRA could be regulated if the immunogenicity of the weak non-B cell-reactive determinants (new antigenic determinants) in DNP30-HRA could be manipulated by adjuvants and dosage. Complete Freund adjuvant and incomplete Freund adjuvant increased the immunogenicity of the new antigenic determinants in DNP30-HRA (10 mg) much more than did alum. However, equivalent primary anti-DNP IgE responses were made by all rabbits sensitized with this dose, regardless of the adjuvant used. Larger doses of DNP30-HRA (25 mg) in alum sensitized rabbits for strong delayed-type hypersensitivity reactions to DNP30-HRA and also elicited enhanced and persistent primary anti-DNP IgE responses. Enhanced but transient primary anti-DNP IgE responses were elicited by 25 mg of DNP30-HRA in incomplete Freund adjuvant. In contrast, no primary anti-DNP IgE responses were made to 25 mg of DNP30-HRA in complete Freund adjuvant. Regardless of the adjuvant or dosage used for primary immunization, no secondary anti-DNP IgE responses to DNP30-HRA were detected.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23896965,"openaccessinfo":{"externalids":{"MAG":"1918538255","ACL":null,"DOI":"10.1128\/iai.11.5.955-961.1975","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1128\/iai.11.5.955-961.1975","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Dimethylbenzanthracene-induced rat mammary tumors were defined as either prolactin responsive or prolactin independent on the basis of growth response to prolactin administration. There was no difference in tumor binding of prolactin between the two groups when tumors were biopsied before treatment. Prolactin binding was, however, significantly higher in responding tumors when biopsies were obtained following treatment. By contrast, when tumors were defined as responsive or independent on the basis of response to suppression of serum prolactin with bromoergocryptine, there was significantly higher prolactin binding in the responsive than in the independent group both before and after treatment. During serial treatment with prolactin followed by bromoergocryptine, there was a progressive decline in prolactin binding to tumor biopsies, particularly in prolactin-independent tumors. Prolactin binding to pretreatment tumor biopsies thus did not predict which tumors would respond to administration of prolactin but, for the total group, did indicate tumors likely to regress with prolactin withdrawal. However, the correlation between prolactin binding and tumor regression following hormone withdrawal was not sufficiently strong to permit reliable prediction of behavior for individual tumors. Prolactin-independent growth was associated with decreased prolactin binding to tumor tissue, particularly following manipulation of serum prolactin levels.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8073761,"openaccessinfo":{"externalids":{"MAG":"1599186743","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, error probability analyses are performed for a binary frequency shift-keying (BFSK) system employing L hop\/bit frequency-hopping (FH) spread-spectrum waveforms transmitted over a partial-band multiple tone jamming channel. The receiver's strategy is to apply the output of each channel detector, prior to combining, to a soft limiter (clipper). The aim of this paper is to compare the effects of 1) worst case partial band Gaussian noise jamming with 2) worst case partial band multiple tone jamming. Numerical results of the error rates are graphically displayed as a function of signal-to-jamming power ratio, with L and signal-to-noise ratio as parameters. It is shown that multiple tone jamming yields a higher error rate, but the receiver still offer a diversity gain, as it does for the Gaussian noise case.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":43533949,"openaccessinfo":{"externalids":{"MAG":"2540735119","ACL":null,"DOI":"10.1109\/MILCOM.1986.4805840","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary\nOffspring from a field strain of house flies taken from the L.S.U. poultry farm in the Baton Rouge, Louisiana area in October 1957 were found by topical application to be highly resistant to malathion and DDT with varying degrees of resistance to the other insecticides tested. Malathion had been used exclusively for 3 years. Progeny from field strains taken from the same area in October and December 1958 were more resistant to malathion, perhaps due to continued use of the organic phosphates. In the resistant group the larval period was longer and pupation and emergence extended over a longer time interval than the Orlando, Florida susceptible strain.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":27030711,"openaccessinfo":{"externalids":{"MAG":"2290195007","ACL":null,"DOI":"10.4269\/AJTMH.1959.8.580","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Gastric scintigraphy (GS) is considered the gold standard for gastric emptying rate (GER) measurement; however, it requires expensive equipment and special licensing for radioactive substances. Aim To compare a new nonradioactive, real-time, continuous breath test (CBT) method with GS for the GER measurement. Methods Simultaneous GER analysis by both GS and CBT was carried out on 8 dyspeptic patients and 6 healthy controls. After a 14 hour fast, participants ate a standard meal of 250 Kcal double labeled with 1 mCi of Tc-99m and 100 &mgr;g of C-13 labeled octanoic acid. The participants underwent simultaneous GS for 120 minutes on single-detector &ggr; camera and CBT carried out by attaching the nasal cannula of the system (Oridion, BreathID, Israel), which automatically and continuously collected and analyzed breath samples with real time display. A linear fit model was used to calculate gastric empting half-time. A half-time of more than 100 minutes for GS and 80 minutes for CBT were considered pathologic. The GS and CBT were compared by &kgr; test of agreement in normal\/abnormal results. Results Good correlation was found for GER measurements between GS and the CBT methods with a linear correlation coefficient of R=0.74. The &kgr; test indicated excellent agreement with value of 0.86 for the qualitative determination of pathologic and normal results. Conclusions The novel CBT provides reliable and reasonably accurate data for on-line GER estimate, in a simple manner suitable for medical clinics or bedside setting, without the use of radioactive substances.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12341102,"openaccessinfo":{"externalids":{"MAG":"1977694431","ACL":null,"DOI":"10.1097\/MCG.0b013e3181dadb23","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Machine learning algorithms have been shown to be highly effective in solving optimization problems in a wide range of applications. Such algorithms typically use gradient descent with backpropagation and the chain rule. Hence, the backpropagation fails if intermediate gradients are zero for some functions in the computational graph, because it causes the gradients to collapse when multiplying with zero. Vector quantization is one of those challenging functions for machine learning algorithms, since it is a piece-wise constant function and its gradient is zero almost everywhere. A typical solution is to apply the straight through estimator which simply copies the gradients over the vector quantization function in the backpropagation. Other solutions are based on smooth or stochastic approximation. This study proposes a vector quantization technique called NSVQ, which approximates the vector quantization behavior by substituting a multiplicative noise so that it can be used for machine learning problems. Specifically, the vector quantization error is replaced by product of the original error and a normalized noise vector, the samples of which are drawn from a zero-mean, unit-variance normal distribution. We test our proposed NSVQ in three scenarios with various types of applications. Based on the experiments, the proposed NSVQ achieves more accuracy and faster convergence in comparison to the straight through estimator, exponential moving averages, and the MiniBatchKmeans approaches.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":246425353,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ACCESS.2022.3147670","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One pillar of Model-Driven Development for real-time embedded software is the separation of concerns between application model and target platform. This requires definition of model transformations realizing the mapping of the application model onto the target platform. Real-Time and Embedded Systems design means coping with different target platforms and with heterogeneous constraints related to time, synchronization and memory footprint. However, different target platforms have APIs and implementation patterns that vary significantly so that it is necessary to develop several dedicated model transformations in order to achieve portability between them. Although this is one way to achieve portability, we show in this paper that the cost of portability can be reduced by providing domain-independent model transformations while still ensuring performance requirements are satisfied.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":3}},"corpusid":2423146,"openaccessinfo":{"externalids":{"MAG":"2147175711","ACL":null,"DOI":"10.1109\/ICECCS.2011.12","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Through the creative manipulation of textual formulations which belong\u00a0neither to the sphere of literature nor to the sphere of narrative, Thanasis\u00a0Valtinos' prose constructs a space between fiction and reality. This paper\u00a0explores Valtinos' unusual forms of representation by examining the \"Synaxari\u00a0of Andreas Kordopatis\". It argues that the \"in-between\" space facilitates\u00a0the co-presence of two voices: the character who wants to bring his experience\u00a0to the realm of language and the writer who wants to capture the tone of the\u00a0character's voice. Both voices find their articulation in a single form which\u00a0is congruent to the to their aspirations. As the interstitial experience of the\u00a0character designates a space between desire and fulfilment that fires up hope\u00a0and the potentiality of dreaming, so Valtinos' narrative becomes \"foreign\" to\u00a0literature in order to question ordinary views on perception and representation\u00a0and to give voice to the experience of anonymity.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":151937283,"openaccessinfo":{"externalids":{"MAG":"2538269228","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nDelta-like ligand 4 (DLL4) is a membrane bound ligand for Notch receptors essential for functional vessel formation during development and angiogenesis. We have shown previously that MEDI0639, a human anti-DLL4 antibody, has potent in vitro and in vivo activity in blocking DLL4-Notch interaction. However, because MEDI0639 has low binding affinity to mouse DLL4, to enable in vivo pharmacology studies using xenograft tumor models in mice, MEDI0639 was engineered to bind more strongly to mouse DLL4. The resulting affinity-optimized variant antibody (anti-mDLL4 mAb) bound with high affinity to both human and mouse DLL4 and maintained binding specificity to DLL4. In a number of human cancer xenograft models in nude mice, the MEDI0639 variant antibody markedly inhibited the growth of tumors. qRT-PCR analysis using the Fluidigm platform showed decreases in mouse genes downstream of the Notch signaling pathway at efficacious doses, indicating on-target antibody effect on tumor vasculature. In addition, IHC and imaging analysis of xenograft tumors from the anti-DLL4 mAb dosed animals showed a dose-dependent increase in microvessel density and decrease in tumor perfusion compared to the control groups. In summary, we describe here the generation of mouse and human DLL4 cross-reactive antibody and the utilization of this antibody in demonstrating a positive correlation between the anticipated mechanism of action of DLL4 blockade on vasculature and inhibition of tumor growth.\n\nCitation Format: Song H. Cho, David W. Jenkins, Patrick Strout, Martin Korade, Haihong Zhong, Ching Ching Leow, Shannon Breen, Jon Chesebrough, Nicholas Holoweckyj, Ivan Inigo, Gennady Gololobov, Ping Tsui, Kimberly Cook, Melissa Damschroder, Meggan Czapiga, Philip Brohawn, Jiaqi Huang, Sally-Ann Ricketts, Juliana Maynard, Adeela Kamal. A mouse DLL4 cross-reactive variant of MEDI0639 disrupts functional vessel formation and inhibits tumor growth in preclinical models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5098. doi:10.1158\/1538-7445.AM2013-5098","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":84335490,"openaccessinfo":{"externalids":{"MAG":"1998110257","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-5098","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Payroll taxes and payroll deductions became ubiquitous in the United States by the mid-1940s, crucial to the financing of the emerging \"mixed\" welfare state as well as World War II. While scholars have firmly established the importance of elements of the warfare\/welfare state such as Social Security, employer-based pensions and health insurance, and the mass income tax, voluntary sector institutions have garnered less attention. The history of payroll deduction demonstrates how this \"infrastructural power\" also advantaged institutions outside of the state, notably, charitable fundraising organizations commonly known as Community Chests (the forerunners of the United Way). Chests began to look toward the payroll deduction in the 1920s as an efficient and effective way of extracting donations from workers of modest means\u2014though these were often fiercely resisted by an empowered labor movement in the 1930s. But it took the state's vast expansion of deductions during World War II, and the patriotic impulse of donating to war-related charities, to convince industrial unions and employers to support this method of donation. Like the income tax, this change in charitable giving remained in place after the war and became a vital element of financing this part of the public\u2013private social safety net\u2014a crucial boost to the voluntary sector from the state.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":147280077,"openaccessinfo":{"externalids":{"MAG":"2333153044","ACL":null,"DOI":"10.1017\/S0898588X14000145","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The murine Mls-1 antigen is the prototype of endogenous superantigens, molecules whose activities lead to deletion of T cells expressing certain T-cell receptor V beta genes from the mature repertoire. However, Mls-1 also stimulates T cells expressing these particular V beta genes (V beta 6, V beta 7, V beta 8.1, and V beta 9) in vitro, making it one of the strongest known T-cell activators. We have recently reported that the Mls-1 gene is closely linked to the endogenous mammary tumor virus Mtv-7. We now demonstrate that Mls-1 is encoded by the open reading frame in the U3 region of the long terminal repeat of Mtv-7. However, control of expression of this molecule seems complex, depending on the promoter used for the transfection experiments. The sequence of the Mtv-7 open reading frame differs from all other known mammary tumor virus open reading frame sequences in the 3' end, suggesting that the T-cell receptor V beta specificity is conferred by the C terminus of the molecule. The predicted structure of the protein encoded by the open reading frame is consistent with a type II transmembrane molecule where the C terminus is extracellular.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21096441,"openaccessinfo":{"externalids":{"MAG":"2057934120","ACL":null,"DOI":"10.1073\/PNAS.89.12.5432","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Midyear Council Meeting of The Paleontological Society (PS) was called to order by President William I. Ausich on 15 March 2003 at 8:05 hrs in Room 308 of the Fogelman Center on the campus of The University of Memphis. Attending were Council members Patricia H. \"Tricia\" Kelley, David J. Bottjer, Mark E. Patzkowsky, Carl W. Stock, Robert A. Gastaldo, Steven M. Holland, Alycia L. Rode, Ann F. \"Nancy\" Budd, John M. Pandolfi, Mark A. Wilson, Russell H. \"Tim\" White, Ralph Hitz, Lance L. Lambert, and Reese Barrick.\n\nMinutes of the 2002 Annual Council Meeting were approved by acclamation.\n\nBill Ausich presented his President's Report, first thanking Lance Lambert for making meeting arrangements. President Ausich then reported on the meeting of the presidents of Geological Society of America (GSA) Associated and Affiliated Societies, which took place February 2003 in Boulder, CO. GSA's financial situation has improved. They have a new, part-time person in their education and outreach position, Gary Lewis. Ausich also attended the American Geological Institute (AGI) meeting in Washington, DC in December 2002. One topic of discussion was \"Paleontology in the National Park System.\" Paleontology appears to be a high priority for the Parks. There is a Parks' Paleontologist, who is preparing a report on known paleontological resources in the National Parks. The Parks are going to hire a Visiting Chief Scientist to come to Washington for a couple of years, and they would not mind that being a paleontologist. Returning to the meeting with GSA, President Ausich noted that they were very responsive to our concerns\u2014he noted what a good job Lisa Park and Rowan Lockwood are doing for the PS on the Joint Technical Program Committee (JTPC). It is not unusual for paleontological sessions at GSA meetings to be held in rooms that are too small \u2026","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129248554,"openaccessinfo":{"externalids":{"MAG":"2063317378","ACL":null,"DOI":"10.1666\/0022-3360(2004)078<0802:POTMCM>2.0.CO;2","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT The purpose of this study was to determine whether changes in personality occur in teenagers during one-month homestays in Japan. The sample consisted of 154 exchangees and 112 control group members who did not travel abroad. The California Psychological Inventory was administered to both groups prior to the exchange, again at its conclusion, and a third time four months later. Antecedent information was collected using a pre-exchange questionnaire. Analysis of covariance was used to determine if the pretest and posttest scores for the two groups were significantly different. Nonparametric tests were used to determine if certain overseas group antecedent subpopulations changed differently. The overseas group increased in flexibility and independence and became less conventional as compared to the control group. Travelers who had studied a foreign language for one or two semesters experienced no significant changes; those with no previous language study and those who had studied a language for three or four semesters changed significantly. Exchangees who were the first member of their family to travel abroad and those who personally paid a high percentage of their trip expenses also changed significantly.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":144947958,"openaccessinfo":{"externalids":{"MAG":"2052976700","ACL":null,"DOI":"10.1111\/J.1944-9720.1988.TB03121.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In recent years, there is increasing attention for the engagement of the public with science and (emerging) technology. In academic literature, public engagement with science (PES) is often perceived as the new and royal road for a responsible development of technology. Also in society, there is an increased implementation of PES projects in various formats and on several levels of policy-making. Large parts of literature focus on the normative discussion on PES. However, a smaller portion discusses how PES projects play out as a result of the perceptions and the interactions of the various actors involved. This study aims to provide a better understanding of the way PES is adopted by the involved actors and how this relates to the intended format of the organizers. The inquiry focuses on a specific project: the Dutch 'Nanokaravaan'. This is one of the first public dialogue events on nanotechnology in the Netherlands and is organized by five science cafes. \nIn this thesis, a social constructivist approach is developed to explore the social shaping of PES. Initially, PES projects are 'designed' in a specific way as an instrument to facilitate certain social interactions. Hence, this thesis conceptualizes PES as a specific type of technology, namely a 'governance technology'. On the basis of this analogy, the inquiry draws on conceptual and methodological insights from technology studies. The approach is mainly based on the social construction of technology (SCOT) approach. SCOT focuses on the way a new technology is constructed by its attributed meanings. These meanings matter substantially for how a technology is constructed and adopted. The first part of the developed social constructivist approach focuses on the attributed meanings of the Nanokaravaan by the involved actors. The second part analyzes the social construction of the project as the result of the meanings that the actors attach to their own roles and those of others in setting up public engagement. The empirical inquiry examines three meetings by separately interviewing an organizer, an invited speaker and two visitors. The Nanokaravaan is intended as an informal and open dialogue, but the analysis showed that the format of the Nanokaravaan holds much interpretative flexibility. Although the formats of the meetings had much in common, it appeared that different factors influenced the actual public engagement during the meetings. The main factors were: the 'stage' setting of the speaker; the structuring of the interaction by the organizers and the speakers; and the urgency of the discussed topic. Finally, these findings showed that the Nanokaravaan holds openings for public engagement but these openings needed effort","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":54817236,"openaccessinfo":{"externalids":{"MAG":"33591416","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"CONTEXT\nMultiple scores exist to characterize organ dysfunction in children.\n\n\nOBJECTIVE\nTo review the literature on multiple organ dysfunction (MOD) scoring systems to estimate severity of illness and to characterize the performance characteristics of currently used scoring tools and clinical assessments for organ dysfunction in critically ill children.\n\n\nDATA SOURCES\nElectronic searches of PubMed and Embase were conducted from January 1992 to January 2020.\n\n\nSTUDY SELECTION\nStudies were included if they evaluated critically ill children with MOD, evaluated the performance characteristics of scoring tools for MOD, and assessed outcomes related to mortality, functional status, organ-specific outcomes, or other patient-centered outcomes.\n\n\nDATA EXTRACTION\nData were abstracted into a standard data extraction form by a task force member.\n\n\nRESULTS\nOf 1152 unique abstracts screened, 156 full text studies were assessed including a total of 54 eligible studies. The most commonly reported scores were the Pediatric Logistic Organ Dysfunction Score (PELOD), pediatric Sequential Organ Failure Assessment score (pSOFA), Pediatric Index of Mortality (PIM), PRISM, and counts of organ dysfunction using the International Pediatric Sepsis Definition Consensus Conference. Cut-offs for specific organ dysfunction criteria, diagnostic elements included, and use of counts versus weighting varied substantially.\n\n\nLIMITATIONS\nWhile scores demonstrated an increase in mortality associated with the severity and number of organ dysfunctions, the performance ranged widely.\n\n\nCONCLUSIONS\nThe multitude of scores on organ dysfunction to assess severity of illness indicates a need for unified and data-driven organ dysfunction criteria, derived and validated in large, heterogenous international databases of critically ill children.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245594213,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1542\/peds.2021-052888D","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: To survey how laboratories report, and neonatologists perceive them to report, the presence of haemolysis in neonatal blood samples. Methods: A questionnaire was sent to clinical biochemists and neonatologists in 88 hospitals believed to be using Roche methodology. Results: A 49% response rate was obtained. Seventeen hospitals were excluded from analysis owing to incomplete questionnaires or altered methodology. Of the remaining 71 hospitals, 30 (42%) laboratories and 18 (25%) neonatologists responded - where both responded, none gave identical replies. Eighteen laboratories admitted the use of serum indices to make decisions on haemolysed samples. Although recommended interference limits are available from Roche, there was little consensus between laboratories. Conclusions: Laboratories should have clear guidelines on the processing of haemolysed samples from neonates and these should be adequately communicated to those responsible for their direct care.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33938464,"openaccessinfo":{"externalids":{"MAG":"2089617444","ACL":null,"DOI":"10.1258\/000456307780118208","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Despite a global commitment to minimise the impact of tourism on the environment and maximise its benefits for local communities, the pressure of tourism on natural resources is still increasing. In this context, ecotourism becomes key to safeguarding the integrity of the ecosystem while producing economic benefits that can ultimately encourage the conservation of the environment. However, despite its benefits, there is still a need to develop the market presence of ecotourism strategies and initiatives. Thus, tourists' positive intention toward ecotourism and organisations that seek to meet the demand of the increasingly environmentally conscious market are key to the success of ecotourism initiatives. In the context of the information era, organisations may create a trustworthy relationship with ecotourists by providing them with accurate and engaging information on their environmental policies and actions. This relationship may result in the emergence of a critical intangible asset such as eco-tourism capital as tourists' decisions are based on image, perception and recommendations from social groups. For organisations to benefit from eco-tourism capital, they should use social media to generate opportunities for eco-tourists to experience and appreciate nature, respect local cultures, support local communities and minimise and mitigate their negative impact on the environment. Based on the above, the aim of this study is to explore, via a descriptive analysis of data collected from international ecotourists, how social media can be used to create eco-tourism capital. To that aim, we explore factors relating to ecotourism knowledge, green trust, and exposure to information on social media provided by ecotourism service providers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":2,"2024-22":1}},"corpusid":261599112,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.34190\/eckm.24.2.1318","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/papers.academic-conferences.org\/index.php\/eckm\/article\/download\/1318\/1471","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Life expectancy at birth is an appropriate index representing abridged population mortality rate in the form of a number which can reflect socio conomic status in each community. Thus, the purpose of the present study was to estimate life expectancy at birth in Torbat Heydariyeh County in northeastern Iran during 2015-2016. This study was a cross-sectional study using mortality data from 2015 to 2016 among the population covered by Torbat Heydariyeh University of Medical Sciences. The raw demographic data and the number of deaths in each age group was obtained from the Vice-Chancellor's Office for Health Affairs in the given County and then life expectancy for each age group and gender was separately calculated using the Excel software and based on the indices associated with Life Table. Life expectancy at birth in Torbat Heydariyeh County in 2015 was estimated equal to 75.70 years old (78 years old for women and 72.1 years old for men). Moreover, life expectancy rates in 2016 for women and men were 80.6 and 79.1 years old, respectively. Life expectancy rates in Torbat Heydariyeh County during 2015-2016 compared with the national values of this index in those years were higher. During one year, life expectancy at birth in the given population had an increasing trend and it was higher in men than women.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":81725199,"openaccessinfo":{"externalids":{"MAG":"2900776573","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Infantile hydrocephalus due to unrecognized neonatal-onset meningitis\/ventriculitis, was studied retrospectively using 1991-1998 chart review. Seventy two patients with hydrocephalus were reviewed. Thirteen infants had hydrocephalus associated with active meningitis\/ventriculitis which had remained unrecognized. Active meningitis\/ventriculitis was confirmed by the finding of an abnormal lumbar and ventricular CSF with or without positive culture. All had perinatal risk factors and 10\/13 had been given antibiotics in the postnatal period. 6\/13 infants appeared to be well. The most common presentation was increasing head size. All lumbar and ventricular CSFs were abnormal and 10\/13 had positive cultures as well. Imaging revealed hydrocephalus in all. The infants were treated with antibiotics for a mean of 32.8 days before VP shunting. 7\/11 were severely disabled. Unrecognized active meningitis\/ventriculitis is an important cause of infantile hydrocephalus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7732322,"openaccessinfo":{"externalids":{"MAG":"12170690","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The statutory 'phonics screening check' was introduced in 2012 and reflects the current emphasis in England on teaching early reading through systematic synthetic phonics. The check is intended to assess children's phonic abilities and their knowledge of 85 grapheme\u2013phoneme correspondences (GPCs) through decoding 20 real words and 20 pseudo words. Since the national rollout, little attention has been devoted to the content of the checks. The current paper, therefore, reviews the first three years of the check between 2012 and 2014 to examine how the 85 specified GPCs have been assessed and whether children are only using decoding skills to read the words. The analysis found that out of the 85 GPCs considered testable by the check, just 15 GPCs accounted for 67% of all GPC occurrences, with 27 of the 85 specified GPCs (31.8%) not appearing at all. Where a grapheme represented more than one phoneme, the most frequently occurring pronunciation was assessed in 72.2% of cases, with vocabulary knowledge being required to determine the correct pronunciation within real words where multiple pronunciations were possible. The GPCs assessed, therefore, do not reflect the full range of GPCs that it is expected will be taught within a systematic synthetic phonics approach. Furthermore, children's ability to decode real words is dependent on their vocabulary knowledge, not just their phonic skills. These results question the purpose and validity of the phonics screening check and the role of synthetic phonics for teaching early reading.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":151427865,"openaccessinfo":{"externalids":{"MAG":"2591911012","ACL":null,"DOI":"10.1002\/BERJ.3269","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a microstrip triplexer with multiband performances by using cascaded trisection (CT) filters. Each CT section is composed by three directly coupled resonators with a cross coupling. The cross coupling produces a single attenuation pole at the finite frequency. Furthermore, each trisection filter controls a specific channel frequency independently. To obtain good isolation response, the resonators are properly located with respect to the input and output feeding lines to suppress the channel interfering and meet the design specifications for mobile communications.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":13242727,"openaccessinfo":{"externalids":{"MAG":"2072626946","ACL":null,"DOI":"10.1109\/APS.2013.6711061","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study explored the personal characteristics and the health and health-related concerns reported by members of the local homeless population in order to design population-specific health programming. The study also examined whether there were significant differences between homeless who are shelter residents and those who are not. An exploratory descriptive design was used to analyze retrospective data collected by a local County Health Department in interviews of 132 homeless adults. The demographic characteristics found reflect many common patterns: marked over-representation of males, mean age in the mid-thirties, education levels comparable to similar socio-economic groups, high unemployment rates, and low health insurance rates. One third of the sample reported self-assessed health statuses of fair or poor. The most frequently identified physical health issue was joint problems, followed by cardiovascular disease. Depression was mentioned most frequently as a self-identified mental health problem. Loneliness was the number one fear identified. Chi Square analysis showed that homeless who did not stay in shelters were significantly longer term residents (p < 0.0001) of the community and reported fear of loneliness significantly more frequently (p < 0.01). This study identifies health concerns that local homeless people themselves find important and provides direction for development of sound population-specific health programming.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7813201,"openaccessinfo":{"externalids":{"MAG":"2004111914","ACL":null,"DOI":"10.1111\/J.1525-1446.1998.TB00366.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present the case of a 73-year-old male patient with a collision tumor in the right ear, consisting of a basal cell carcinoma and melanoma in situ. He was managed with Mohs micrographic surgery combining paraffin-embedded sections and frozen sections. Multiple surgical stages were required to obtain tumor-free margins. The surgical defect was reconstructed by plastic surgery, achieving the preservation of the ear. The technique of combining two processing sections is useful in the treatment of the collision of basal cell carcinoma with malignant melanoma.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250466712,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.7759\/cureus.26747","PubMedCentral":"9365029","ArXiv":null},"license":null,"url":"https:\/\/www.cureus.com\/articles\/103235-combined-mohs-micrographic-surgery-in-a-collision-tumor.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A data analytic technique is described for use in automated cervical cytology. The method entails the application of a two-dimensional Fourier transform to histogram data obtained by flow microfluorometry and the subsequent use of the Fourier coefficients as parameters for pattern classification. Analyses were performed on 186 samples including material from 62 positive and 124 negative cases. Cell suspensions were stained with propidium iodide and fluorescein isothiocyanate, and red and green cytofluoresence were measured simultaneously. The two-dimensional histogram data were normalized, the Fourier transform was applied, and a multivariate classifier based on 30 coefficients was assembled using a training set of half the original series. Performance was then assessed on the remaining cases. Overall accuracy was 79.6%, with a false-positive rate of 14.8% and a false-negative rate of 31.2%. The potential applicability of this approach as the basis of a practical screening system is discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41757568,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT We examined the influence of nutritional status, body fat, and anemia on the physical fitness (PFI) of tribal adolescents. Weight, height, skinfold thickness, PFI, and hemoglobin levels of 147 adolescents (11 to 16 years) were measured. The experience of cycling was recorded. Overall, 31.3% were mildly, 12.9% were moderately, and 10.9% were severely thin. The majority (81.6%) were nonanemic. All had \"poor\" PFI scores. Hemoglobin levels were significantly associated with PFI scores in boys and girls. Experience of cycling also predicted PFI in girls. Nutritional status, hemoglobin level, and physical activity were associated with the fitness levels of these adolescents.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":9151048,"openaccessinfo":{"externalids":{"MAG":"2769721377","ACL":null,"DOI":"10.1080\/03670244.2017.1399370","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In recent years worldwide there has been a considerable increase in the number of middle and older aged patients who undergo total hip replacement, and following surgery they would again like to live an active life, therefore they take part in everyday traffi c as either drivers or passengers of motor vehicles. In head-on collisions there is a relatively high rate of thigh bone, hip joint and pelvic fractures or traumatic dislocation of the hip joint the so called dashboard injury, in cases like this a replaced hip is exposed to greater dangers. We searched the literature for biomechanical examinations of these special joint circumstances, since the replaced hip can not be compared to a healthy hip either biologically or mechanically. The reason this is important, because in these patients it might be advisable to fi nd a solution that takes this into consideration during surgery. We could not fi nd literature examining this question on the internet to this day. DOI:\u00a0 10.17489\/biohun\/2011\/1\/05","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":113182681,"openaccessinfo":{"externalids":{"MAG":"2241487129","ACL":null,"DOI":"10.15289\/BH.V4I1.105","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The use of the dual excitation system for improving the overall performance of a self-excited synchronous machines is considered, along with the replacement of the compound transformer and rectifier bridge by a potential transformer and thyristor bridge for the self-excitation system. The output DC voltage of the bridge is controlled over a wide range by an automatic feedback control circuit to vary the firing angle of the thyristors in such a way that the terminal voltage is sustained at a constant value. The mathematical models for two distinctive alternatives of the excitation system are derived. The mathematical model thus derived is suitable for transient, dynamic as well as steady-state analysis. However it should be modified to investigate the steady-state and dynamic performance. Exact steady-state operating points are achieved by solving the steady-state equations obtained from the general model. Charts describing the performance of the self-dual excited synchronous machine under steady-state operation for the two alternatives of the excitation system have been calculated at different values of the power factor, i.e., the turns ratio of the transformer and the ratio of field currents. The experimental results obtained on a 7.6 kVA induction machine converted to a d-q synchronous machine confirm the validity and accuracy of the analysis and mathematical models developed IEEE Transaction on Energy Conversion, Vol. 3, No., 2, June. 1988, pp.305 -314. 1988, January Abstract","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201638213,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A competitive adsorption of Cu2+, Ni2+ and Zn2+ ions from a synthetic wastewater onto (Fe3O4) nanomaterial was studied. Experimental parameters included pH, initial metal concentrations, and temperature was studied to obtain equilibrium data for adsorption, onto nanosorbent. The results indicate that the uptake capacities were 11.5, 6.07 and 9.68 mg\/g for Cu2+, Ni2+and Zn2+, respectively, onto nanosorbent. The best values of pH and contact time were 6 and 50 min., respectively. For these metals, the equilibrium isotherm for single component is of a favorable type and Freundlich model gave the best model for representing the experimental data. The Combination of Langmuir- Freundlich model best represented the isotherms binary and ternary component systems. In single, binary and ternary component systems, Cu2+ was always adsorbed more favorable onto nanosorbent than Zn2+and Ni2+. The results of thermodynamic study showed that the adsorption process is endothermic and physical nature.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":198339458,"openaccessinfo":{"externalids":{"MAG":"2954821601","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper explores practical and conceptual implications of using Server-Aided Signatures (SAS). SAS is a signature method that relies on partially-trusted servers for generating public key signatures for regular users. Besides its two primary goals of 1) aiding small, resource-limited devices in computing heavy-weight (normally expensive) digital signatures and 2) fast certificate revocation, SAS also offers signature causality and has some interesting features such as built-in attack detection for users and DoS resistance for servers.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251285796,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The term \"antiphospholipid antibodies\" describing a laboratory hallmark of antiphospholipid syndrome (APS) is a misnomer. It suggests that antibodies are directed against phospholipids. Meanwhile the specific antigens are in fact proteins demonstrating an affinity to phospholipids. In APS antibodies directed against a serum protein, beta2 glycoprotein-I, play most probably a pathogenic role and are strongly associated with clinical symptoms of the syndrome. Putative mechanisms of action of anti-beta2 glycoprotein-I antibodies are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29860030,"openaccessinfo":{"externalids":{"MAG":"2414938512","ACL":null,"DOI":"10.20452\/PAMW.276","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Zinc has a critical role in metabolism and growth. This study aims to determine the effects of low-energy diets differing in macronutrient composition on zinc intake, estimated zinc bioavailability (phytate:zinc molar ratio) and plasma zinc concentration and associations between zinc status and cardiometabolic markers in obese adolescents with clinical insulin resistance (IR). Methods: Eighty-seven obese adolescents (10-17 years, body mass index z-score 2.3 \u00b1 0.37) with clinical IR were randomized to a low-energy diet (6.0-8.0 MJ), which was either high carbohydrate or moderate carbohydrate with increased protein. Twenty-four-hour dietary recalls were collected at 6, 9 and 12 weeks. Plasma zinc concentration and cardiometabolic markers were assessed at baseline and 12 weeks. Results: Zinc intake did not differ between the 2 diet groups (p = 0.612). The high-carbohydrate group had a higher phytate intake (894 vs. 671 mg, p = 0.018) and phytate:zinc molar ratio (9.4 vs. 7.4, p = 0.009) than the increased-protein group. Plasma zinc concentration did not change from baseline in either of the diet groups, but correlated positively with zinc intake (r = 0.235, p = 0.042) and % energy from protein (r = 0.383, p = 0.001), and inversely with % energy from carbohydrate (r = -0.296, p = 0.010). Conclusions: Low energy diets for obese adolescents at risk of diabetes may need increased protein content to optimize zinc bioavailability.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":33232134,"openaccessinfo":{"externalids":{"MAG":"2537723158","ACL":null,"DOI":"10.1159\/000450728","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"A model for the oscillation of gas bubbles encapsulated in a thin shell has been developed. The model depends on viscous and elastic properties of the shell, described by thickness, shear modulus, and shear viscosity. This theory was used to describe an experimental ultrasound contrast agent from Nycomed, composed of air bubbles encapsulated in a polymer shell. Theoretical calculations were compared with measurements of acoustic attenuation at amplitudes where bubble oscillations are linear. A good fit between measured and calculated results was obtained. The results were used to estimate the viscoelastic properties of the shell material. The shell shear modulus was estimated to between 10.6 and 12.9 MPa, the shell viscosity was estimated to between 0.39 and 0.49 Pas. The shell thickness was 5% of the particle radius. These results imply that the particles are around 20 times more rigid than free air bubbles, and that the oscillations are heavily damped, corresponding to Q-values around 1. We conclude that the shell strongly alters the acoustic behavior of the bubbles: The stiffness and viscosity of the particles are mainly determined by the encapsulating shell, not by the air inside.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7779810,"openaccessinfo":{"externalids":{"MAG":"2007292189","ACL":null,"DOI":"10.1121\/1.428557","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Communication is essential to the performance of software development teams. But assuming the effect of communication on team performance to be linearly positive has been questioned in the literature. Based on team development theory and team cognition theory, this study contends that the effect of communication is dynamic and contingent on team progress. To assess the dynamic effects of communication, a longitudinal study was conducted of 73 student software development teams. Three models of communication were tested: linear model, time model, and team cognition model. The results revealed that different communication methods (emails, calls, and meetings) presented systematically changing effects on team performance as team progressed. The frequencies of emails and meetings presented increasing effects, while the frequency of telephone calls presented a decreasing effect, on team performance with time passage and the development of team cognition. An optimal model emerged from the testing results. Implications for systems development researchers and practitioners are also discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":56230720,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The three-dimensional structure of human recombinant interleukin-1 beta has been determined at 0.24 nm resolution by X-ray crystallographic techniques. The partially refined model has a crystallographic R-factor of just under 19%. The structure is composed of 12 beta-strands forming a complex network of hydrogen bonds. The core of the structure can best be described as a tetrahedron whose edges are each formed by two antiparallel beta-strands. The interior of this structure is filled with hydrophobic side-chains. There is a 3-fold repeat in the folding of the polypeptide chain. Although this folding pattern suggests gene triplication, no significant internal sequence homology between topologically corresponding residues exists. The folding topology of interleukin-1 beta is very similar to that described by A. D. McLachlan [(1979) J. Mol. Biol. 133, 557-563] for soybean trypsin inhibitor.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19895338,"openaccessinfo":{"externalids":{"MAG":"2368593508","ACL":null,"DOI":"10.1042\/BST0160949","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"IGBT modules used in series and parallel to satisfy the requirement in high-power DC circuit breakers are often prone to large-current destruction due to current unbalance between paralleled IGBTs. It is of great importance to identify the current unbalance causes and to find a method optimizing the current sharing of paralleled IGBTs. In this paper the current-sharing influencing factors are discussed and verified by simulation. Two possible circuit topologies used in DC circuit breakers are proposed and simulated to see their performance in current sharing. The results show that one of them can provide us with a simple and effective method to achieve good current balancing in the DC circuit breaker application.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":113502859,"openaccessinfo":{"externalids":{"MAG":"2473431912","ACL":null,"DOI":"10.1051\/MATECCONF\/20166301010","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Customers are influenced not only by how much they trust a company and its representatives but also by how much they trust the broader context in which the market exchange is taking place. In this article, the authors test two rival sociological perspectives regarding the influence of customer trust in the broader context. One perspective proposes that trust in the context replaces trust in individual firms and their representatives. This view suggests that firm\/representative trust is not always critical, especially for customers with high trust in the context. An alternative perspective is that trust in the context fosters and legitimates trust in firms and their representatives. This view implies that firm\/representative trust is a necessary mediator of the influence of trust in the context. The authors test predictions based on both perspectives, using empirical results from two studies implemented in two countries. The results from both studies support the proposition that trust in firms and their representatives is a necessary mediator of trust in the broader context.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":167400416,"openaccessinfo":{"externalids":{"MAG":"2288919543","ACL":null,"DOI":"10.1509\/jmkr.45.2.241","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Braun, L. C., Gillman, J. H., Hoover, E. E. and Russelle, M. P. 2011. Nitrogen fertilization for new plantings of hybrid hazelnuts in the Upper Midwest of the United States of America. Can. J. Plant Sci. 91: 773-782. Seed-propagated hybrids of Corylus avellana and C. americana are a potential crop for the Upper Midwest. Current N recommendations for hazelnuts are based on research on clonally propagated C. avellana in Oregon and may not be applicable in the Upper Midwest due to differing soils, climate, and plant genetics. We established three field plots in 2003 to test N fertilization rates on new plantings, with rates up to 33 g N plant-1 as ammonium nitrate applied annually in the spring, starting 2 wk after transplanting. We observed a strong negative linear effect of N rate on plant survival. In the second year we added trials on same-aged plants that had not previously been fertilized and found no N effect on survival. We concluded that waiting 1 yr after transplanting before fertilizing increases plant survival, but even then N requirements during establishment years are very low for hybrid hazelnuts. Standard leaf N concentrations for C. avellana in Oregon are roughly applicable to hybrid hazelnuts, except that the threshold between deficiency and sufficiency should be raised slightly to 1.9% N. The current threshold between deficient and sufficient, 2.2%, should be regarded as a target, rather than as a threshold to be exceeded.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":86069826,"openaccessinfo":{"externalids":{"MAG":"2174648297","ACL":null,"DOI":"10.1139\/CJPS2011-015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intensive land use is one of the main drivers contributing to the loss of pollinating insects due to the distribution of pesticides and the reduction of flower diversity. This work analyzes honey bee pollen samples taken from areas of different agricultural intensity. The aim is to classify the plant species contained in the pollen samples using DNA barcodes and nanopore sequencing in order to evaluate the influence of different agro-environmental measures on the foraging behavior of honey bees. First results concern the DNA extraction and the identification of universal primer sequences in preparation for sequencing with the\u00a0MinION Mk1c\u00a0from\u00a0Oxford Nanopore Technologies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":254906255,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.52825\/ocp.v2i.166","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.tib-op.org\/ojs\/index.php\/ocp\/article\/download\/166\/374","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Some rules of good scientific writing Dmitry Budker 1, \u2217 Department of Physics, University of California, Berkeley, CA 94720-7300 (Dated: August 21, 2008) arXiv:physics\/0608246v3 [physics.gen-ph] 21 Aug 2008 A non-native English speaking physics professor formulates obvious yet useful rules for writing research papers. PACS numbers: 01.20.+x I. INTRODUCTION There are many volumes written about technical writ- ing, and I probably do not have too much original mate- rial to add to them. Yet, whenever a student brings me a draft of their first research paper, I invariably see an almost universal set of problems. Some of these probably stem from the way writing is taught at school. As an ex- ample, at school we are taught to enrich our writing by avoiding repeating the same term and using synonyms instead. Unfortunately, if one is writing a scientific pa- per, using different words for the same object could be a disaster. Hoping that these notes will actually be read, let us, without further ado, present II. THE RULES past perfect \u2013 \"it has or had been found\"), unless necessary. \u2022 Saying \"This was demonstrated by J. Doe (1905)\" is correct, while saying \"This was demonstrated in J. Doe (1905)\" is not. \u2022 Things to be compared shall be presented in a sim- ilar manner (for example, on graphs with the same scale). \u2022 One should avoid self-praise, for example, saying that \"interesting results were obtained.\" It should be up to the reader to praise the work! \u2022 The reader does not know what comes next in the paper; consider what the reader should be thinking as they reach this particular point. \u2022 Avoid colloquial terms, for example, \"slam\" in \"The projectile slams the target.\" \u2022 This one is a must: read the finished manuscript! III. CONCLUSION \u2022 A wise man said: \"If you can abstain from writing \u2013 do not write!\" \u2022 \"When in doubt \u2013 cross it out.\" Try it; it really works miracles! \u2022 The contents of a section should match its title. \u2022 An equation appearing in the text should never be presented without comment, unless it is an inter- mediate step in a derivation. \u2022 All \"letters\" (i.e., variables and constants) appear- ing in equations should be explicitly defined, even if seemingly obvious. \u2022 All references, figures, tables, and equations should be numbered in order of appearance. \u2022 Sentences cannot start with an abbreviation [e.g., Fig. 1 or Eq. (2)], or with \"So\" or \"Also.\" \u2022 It is usually better to use past indefinite tense, for example \"it was found\" (as opposed to present or address: email@example.com These rules are quite obvious and \"common sense.\" Yet, formulating them explicitly and keeping them in mind while writing could, hopefully, be useful. It goes without saying, that as with most rules, there may be exceptions. Do we follow our own advice? Judge for yourself by checking out some of the recent published work of our group at http:\/\/socrates.berkeley.edu\/~budker\/. Acknowledgment \u2217 Electronic I am grateful to all of my present and and former stu- dents and co-authors, and, particularly, to Derek F. Jack- son Kimball (now a Professor at California State Univer- sity, East Bay) for making these rules so apparent.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118819885,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using an Extrinsic Affective Simon Task (EAST), we provide the first-ever systematic examination of the role of affective states (negative and positive affectivity, depression, anxiety) and personality traits (alexithymia, optimism) in automatic evaluation effects. Results revealed that the EAST effect was negatively associated with depressive mood even if others affective states and traits were simultaneously entered in a regression model. These findings could reflect a preference for a systematic information processing style elicited during sadness. More generally, the present findings suggest that implicit attitudes measures that capitalise on automatic evaluation effects may lack validity when measuring attitudes of individuals who have negative emotional states. Individual measures relating to affective differences may thus contribute to better predicting the implicit attitudebehaviour link. Copyright # 2007 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":146790501,"openaccessinfo":{"externalids":{"MAG":"2185512790","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nHeart rate, sensitive to sympathetic activation, is known to change during sexual arousal and therefore may be a useful tool for investigating psychosomatic differences between sexually functional and dysfunctional men. However, heart rate during arousal also tends to be highly variable across individual men, making its predictability based on group patterns relatively poor.\n\n\nAIM\nWe wanted to determine whether individual men show idiosyncratic heart rate patterns during sexual arousal, that is, whether they exhibit consistent patterns across similar (though not identical) stimulus situations.\n\n\nMAIN OUTCOME MEASURE\nAgreement between heart rates under the two conditions, visual sexual stimulation (VSS) and VSS + vibrotactile (VIB), was assessed using the concordance correlation coefficient (CCC).\n\n\nMETHODS\n\u2002 Thirty-eight men, 25 of whom were diagnosed with premature ejaculation (PE), were monitored for penile response and heart rate under two similar (though not identical) conditions: a 9-minute erotic video (VSS), then a 9-minute erotic video combined with vibrotactile penile stimulation (VSS\u2003+ VIB).\n\n\nRESULTS\nCCC for men with PE was 0.65; for the sexually functional comparison group, CCC was 0.82. For both groups combined, CCC was 0.71. For all groupings, the CCC was relatively high, indicating agreement in heart rate from one session to the next within individual men.\n\n\nCONCLUSIONS\nDespite high intersubject variation in heart rate patterns, individual men show signature heart rates across similar sexual stimulus sessions. Such stereotypy helps explain previous inconsistent findings and may also serve as a marker for the effectiveness of treatments designed to improve ejaculatory control in men with PE.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":7122673,"openaccessinfo":{"externalids":{"MAG":"1536911608","ACL":null,"DOI":"10.1111\/j.1743-6109.2011.02210.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Background: Various modifiable risk factors have been associated with increased risk of cardiovascular disease, with physical activity known to provide multiple health benefits, whilst inactivity is linked to increased prevalence of multiple cardiovascular risk factors. Objective: The aim of this study was to explore the association between physical activity level and personalised cardiovascular risk, in addition to the association between this risk behaviour and other modifiable cardiovascular risk factors. Method: Data was collected from 863 patients aged 40-80 years (54% male, aged 62.18 \u00b1 12.35 years) including, age, body mass index, blood pressure, total cholesterol and HDL cholesterol, smoking status, treatment for hypertension, presence of diabetes and personalised QRISK score. Results: Inactive patients had a statistically significant higher QRISK than those who were physically active and presented greater prevalence of multiple cardiovascular risk factors including diabetes, hypertension and obesity, in addition to negative health behaviours such as smoking. Males presented both statistically significant higher QRISK and prevalence of contributing risk factors. Conclusions: QRISK scores were significantly higher for those reported physically inactive. All other CV risk measures were higher and more prevalent in the inactive populations. All risk factors increased relative risk of the occurrence of high QRISK scores for both genders and males were at increased risk of all negative health behaviours and higher QRISK despite being more active. Key words: Physical activity; cardiovascular disease; cardiovascular risk factors,","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":59152294,"openaccessinfo":{"externalids":{"MAG":"1481652791","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We investigated the susceptibility to antibacterials of 194 strains of Haemophilus influenzae isolated from medical facilities in Gifu prefecture between 2005 and 2006, and compared these results with those of 280 strains of H. influenzae isolated between 1999 and 2000. Additionally, the strains that had been separated between 2005 and 2006 were examined for beta-lactamase (BL) production, the mutation of ftsI gene coding for PBP3, the bla gene coding for TEM type of BL and the serotype. Referring to the CLSI breakpoint, H. influenzae strains were classified into the following categories: (1) beta-lactamase-negative ampicillin-susceptible (BLNAS) strains, which showed BL negative, ampicillin (ABPC) and ampicillin\/sulbactam (ABPC\/SBT)-MIC < or = microg\/ml, (2) beta-lactamase producing ampicillin-resistant (BLPAR) strains, which showed BL producing and ABPC\/SBT-MIC < or =2 microg\/ml, (3) beta-lactamase-negative ampicillin-resistant (BLNAR) strains, which showed BL negative, ABPC and ABPC\/SBT-MIC > or =2 microg\/ml, (4) beta-lactamase-producing amoxicillin\/clavulanic acid-resistant (BLPACR) strains, which showed BL producing and ABPC\/SBT-MIC > or =4 microg\/ml. The prevalence of each resistance class were 71.8% for BLNAS, 7.9% for BLPAR, 19.6% for BLNAR and 0.7% for BLPACR in strains isolated between 1999 and 2000. But they were 38.1% for BLNAS, 4.6% for BLPAR, 54.6% for BLNAR and 2.6% for BLPACR in strains isolated between 2005 and 2006, indicating that the percentage of BLNAS and BLPAR decreased and that of BLNAR and BLPACR increased from 1999-2000 to 2005-2006. On the basis of ftsI substitutions and having bla gene, the strains isolated between 2005 and 2006 were classified into the following distribution: 24.2% for gBLNAS, 4.1% for gBLPAR, 10.8% for gLow-BLNAR, 57.7% for gBLNAR, and 3.1% for gBLPACR-II. Ratio of BLNAR belonging to gBLNAR and gLow-BLNAR based on the ftsI substitutions and having bla gene was higher than that based on the susceptibility pattern. The MIC50 and MIC90 for those strains isolated between 2005 and 2006 were as follows; 0.0039, 0.0156 microg\/ml for garenoxacin, 0.0078, 0.0156 microg\/ml for tosufloxacin and ciprofloxacin, 0.0156, 0.0313 microg\/ml for levofloxacin, 0.0313, 0.0625 microg\/ml for norfloxacin, 0.0625, 0.25 microg\/ml for piperacillin\/ tazobactam, 0.0625, 0.5 microg\/ml for piperacillin, 0.125, 0.25 microg\/ml for ceftriaxone and cefditoren, 0.5, 1 microg\/ml for cefteram, chloramphenicol and tetracycline, 0.5, 2 microg\/ml for cefotaxime, 2, 8 microg\/ml for ampicillin, ampicillin\/sulbactam and cefdinir. In comparison with the values for the strains isolated between 1999 and 2000, the MIC50s of beta-lactam for the strains isolated between 2005 and 2006 increased over 4 times.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10923161,"openaccessinfo":{"externalids":{"MAG":"2412442659","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study is to determine the efficacy of tumor-targeting Salmonella typhimurium A1-R (A1-R) (Cancer Disc. 2, 588-590, 2012) on pancreatic cancer PDOX\u2122 compared to standard chemotherapy. The PDOX\u2122 was grown in transgenic nude red fluorescent protein (RFP) mice in order that the PDOX\u2122 acquire RFP-expressing stroma in order to label the tumor. The RFP-PDOX\u2122 were then orthotopically transplanted to non-transgenic nude mice in order to image tumor growth and drug efficacy. The RFP labeled stroma are stable upon passage. A1-R treatment significantly reduced tumor weight as well as tumor fluorescence area compared to untreated control (p = 0.011), with comparable efficacy of gemcitabine, cisplatin and 5-FU. A1-R had the highest efficacy compared to any of the chemotherapy drugs tested based on Evan9s histological response criteria. The present report demonstrates Salmonella typhimurium A1-R was effective for human pancreatic PDOX\u2122 and is a promising therapy for this highly treatment-resistant disease. Citation Format: Yukihiko Hiroshima, Ming Zhao, Ali Maawy, Yong Zhang, Matthew H.G. Katz, Jason B. Fleming, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman. Pancreatic cancer patient-derived orthotopic xenograft (PDOX\u2122) is effectively targeted by Salmonella typhimurium A1-R. [abstract]. In: Proceedings of the AACR Special Conference: The Translational Impact of Model Organisms in Cancer; Nov 5-8, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(11 Suppl):Abstract nr A40.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":87463937,"openaccessinfo":{"externalids":{"MAG":"2276770932","ACL":null,"DOI":"10.1158\/1557-3125.MODORG-A40","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Coaches are one of the leading people who have a role in athletes' success. Physical and physiological characteristics of many elite athletes are close to each other. The most important psychological factor as the distinguishing element bringing success is the coaches' behavioral approaches to their athletes. It is important to find out the behavioural styles of the coaches of athletes who are representing their countries in international organizations and who are showing top level performance in increasing their countries' success. In this sense, the purpose of this study is to analyze the coaching behaviour styles of the coaches of snowboard cross athletes representing their countries in the world cup. The study is a descriptive study in the model of survey. 3-item personal information form developed by the researcher and Coaching Behaviour Scale for Sport- CBS-S consisting of 7 factors and 47 items were used as data collection tool. The scale was given to 68 of 97 athletes competing for different countries in Snowboard Cross World Cup that was held in Erzurum\/ Turkey in January 2018. Percentage, frequency, mean and average values were used in the analysis of data. Various difference tests were used to find out the differences between variables. 24 female and 44 male athletes participated in the study. Average age of the athletes was found as 25,16\u00b14,53. No significant difference was found in terms of the variables of age, gender and the continent athletes participated from and it was found that athletes assessed the positive behavioural styles of coaches in very high levels (6,98\u00b11,21), while they assessed their negative coaching behaviours in very low levels (1,08\u00b10,14). According to the results obtained, it is recommended for behavioural styles of coaches assessed within the context of similar researches to be applied to other sport branches.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":150599577,"openaccessinfo":{"externalids":{"MAG":"2913129079","ACL":null,"DOI":"10.13189\/UJER.2019.070203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Islamic finance has grown rapidly in the recent years particularly in the Middle East and the world. It receives a great attention of bankers and financial scholars due to its stability during financial shocks and crises. The paper uses empirical analysis to test the role of Islamic banking in enhancing the economic growth of United Arab Emirates (UAE). Gross Domestic Product (GDP), Gross formation (GF), and Foreign Direct Investment (FDI) are used as representatives for economic growth, while Islamic banks' investments are used as a representative for Islamic financial sector in the UAE. The study uses time series techniques to test the link between the variables. In the current study, co-integration along with error correction models is utilized. All econometric work is done using Eviews. The findings reveal that the causal relationship between Islamic banks' investments and economic growth of UAE is supply-leading direction. Furthermore, the findings depict that Islamic investments have contributed in increasing investments and in bringing FDI into the country in the long-term. The study also shows that there is two-way association between Islamic banks' investments and FDI. It shows that FDI supports Islamic banking and Islamic banking brings FDI. The paper concludes that authorities of the UAE should devote more attention for this growing banking sector by facilitating regulations for establishing new Islamic banks and then creating a suitable envi-ronment for their growth and progress in the UAE.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":55418584,"openaccessinfo":{"externalids":{"MAG":"2607943218","ACL":null,"DOI":"10.21511\/BBS.12(1-1).2017.03","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cryptosporidium is a protozoan parasite and the aetiologic agent of a gastrointestinal disease, known as cryptosporidiosis. In this study, a total of 300 faecal samples were collected and analysed for the presence of Cryptosporidium, yeasts and other parasites using direct normal saline, iodine wet preparations, formol-ethylacetate concentration and modified Ziehl Neelsen staining techniques. Using direct normal saline and iodine wet preparation techniques, a total of 25(8.3%) samples out of 300 were positive for Cryptosporidium and yeasts, but the use of formol-ethylacetate concentration increased the number of positive samples for Cryptosporidium and yeasts to 30 (10%). Further application of modified Ziehl Neelsen staining technique to sediments differentiated the aetiologic agents into Cryptosporidium 6 (20%) and yeast-positive 24 (80%). The prevalence of other parasites encountered in this study include; Giardia lamblia, 1 (0.3%); Blastocystis hominis, 1 (0.3%); Entamoeba histolytica, 13 (4.3%); Clonorchis sinensis, 2 (0.7%); Hookworm, 6 (2%); Ascaris lumbricoides, 3 (1%) and Balatidium coli, 1 (0.3%). Thus, the application of only routine wet preparation was less predictive and resulted in 21.7% misdiagnosis (1.7% undetected plus 20% misdiagnosed as yeast). This study buttresses the need for the confirmation of every suspected yeast infection as may be detected in wet examination of faecal specimens, to avoid misdiagnosis. The study also indicates the importance of formol-ethyacetate sedimentation technique in the detection and diagnosis of yeasts, Cryptosporidium, B. hominis and other parasites from stool samples.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":62839406,"openaccessinfo":{"externalids":{"MAG":"2465631187","ACL":null,"DOI":"10.5897\/AJMR12.1511","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Economics is an important component of social science instruction in secondary level education in the Philippines. This paper aims to trace the evolution of economics education in Philippine high school through a review of all available textbooks, from the very beginning of the institution of the subject. Analyzed are the changing context, the correctness of the concepts taught, the language used in the books, the way different contemporary Philippine issues in economic development is treated, and the writer of the textbook himself or herself. The analysis also looks at the guidelines writers use in coming up with reference materials intended for a course in economics for graduating high school students.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":52970228,"openaccessinfo":{"externalids":{"MAG":"2300369438","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \u2013 Popularity of a celebrity having twitter account is generally estimated by the number of twitter account holders following him on twitter. In this paper, we explore some content based features to evaluate their role for estimating the popularity of a celebrity. We try to find out the co-relation of celebrities' popularity with number of other features like frequency of tweets posted by a celebrity and the relevancy of tweets to their domains. We take support of named entity recognition for later task. For the data collection, we collected about 60K tweets of 60 different celebrities with the help of API method provided by twitter. The current study aims to reveal many unseen patterns existing in celebrities' twitter usage that includes computing per day tweet frequency and finding out how it correlates with number of followers. Also we find out the correlations of tweets with domains of the celebrities.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":212590323,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This chapter explores the range of jurisdictional principles that have been developed by various states to address the applicability of ne bis in idem to the prosecution of transnational crimes. It first considers two approaches under international law dealing with criminal jurisdiction before discussing state practice on jurisdictional principles, focusing on territorial jurisdiction, the protective principle, the flag principle, and the active nationality principle. The aut dedere, aut judicare principle, passive nationality principle, the domicile principle, the principle of universal jurisdiction, and the principle of complementary jurisdiction\/secondary jurisdiction are also examined, along with the justifications for states to vest extraterritorial jurisdiction. The chapter concludes with an analysis of solution mechanisms for the prevention of conflicts of jurisdiction and of limitations to jurisdiction.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1}},"corpusid":198702088,"openaccessinfo":{"externalids":{"MAG":"2955645443","ACL":null,"DOI":"10.1093\/OXFORDHB\/9780190659837.013.27","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Classical prodrug design often represents a nonspecific chemical approach to mask undesirable drug properties such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targeted prodrug design represents a new strategy for directed and efficient drug delivery. Particularly, targeting the prodrugs to a specific enzyme or a specific membrane transporter, or both, has potential as a selective drug delivery system in cancer chemotherapy or as an efficient oral drug delivery system. Site-selective targeting with prodrugs can be further enhanced by the simultaneous use of gene delivery to express the requisite enzymes or transporters. This review highlights evolving strategies in targeted prodrug design, including antibody-directed enzyme prodrug therapy, genedirected enzyme prodrug therapy, and peptide transporter-associated prodrug therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":10574095,"openaccessinfo":{"externalids":{"MAG":"2088158673","ACL":null,"DOI":"10.1208\/ps020106","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc2751001?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The prevalence of mobile devices has increased rapidly in recent years. People store valuable data like personal and financial information on those devices. In addition, applying \"bring your own device (BYOD)\" policy in companies has become popular. Hence, mobile devices are also source of valuable and confidential company information. Accordingly, there is a growing need for malware detection methods and tools to protection mobile devices against attacks targeting them. In this study, an automated feature-based static analysis method is applied to detect malicious mobile applications on Android devices. By utilizing the metadata of applications on the official market and an online free malware scanner, the feasibility of a mobile malware detection model using free public sources and having quite acceptable accuracy rates is shown. As opposed to previous studies considering only the requested permissions as feature set, additional market metadata including but not limited to application category, download number, developer name, and average rating are included in the analysis as the feature set for training supervised classification algorithms. Based on an experimental evaluation of the majority voting of antivirus (AV) engines on the free online AV community, applications in the training set are labeled as malicious or benign. Na\u00efve Bayes classification algorithm is chosen as supervised learning algorithm for the detection task. In addition, as filter-based algorithms, Chi-Square, Information Gain and ReliefF feature selection methods are used for overcoming potential overfitting problems. Finally, a quick prototype for showing the feasibility of the detection model is demonstrated with sample case applications.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":1831553,"openaccessinfo":{"externalids":{"MAG":"2565270720","ACL":null,"DOI":"10.1109\/UEMCON.2016.7777867","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In next generation data networks, joint optimization of physical layer parameters and scheduling layer parameters will be necessary to meet the demands of quality of service (QoS)-constrained traffic like video traffic. Until now, such optimization problems considered only simple and non-realistic Markov chain models to represent physical layer channel dynamics. In this paper, we consider the incorporation of realistic channel models in a Markov decision process (MDP) formulation for the QoS-constrained optimization of the physical layer. The channel random process is transformed into an extended Markovian setup through hidden Markov models (HMM) and the solution of the resulting optimization problem is shown to be a partially observable Markov decision process (POMDP). The optimal scheduling agent bases its decision on a parameter that summarizes complete system history until the decision instant. This parameter can he computed at each decision instant based only on newly available information, avoiding the need to record all the past states.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2015-18":1,"unknown":2}},"corpusid":6800621,"openaccessinfo":{"externalids":{"MAG":"2129356797","ACL":null,"DOI":"10.1109\/ICC.2004.1313342","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Implementation of the newest National Curriculum 2013 in every public school gives problem to the teacher's way of thinking especially for language teacher. It is projected to change the language teaching paradigm from literacy approach which gives the students opportunity to use the information from what they read and write to scientific approach that gives students chance to develop their intelligence to higher order thinking in learning language and expected in using it in proper way as life skills equipment in facing the rapid changes of global society system in the near future. Copying this fact about this new curriculum, this article is trying to describe deeper about new feature that brought by curriculum 2013. The aspects start from the concept of curriculum, the assessment process, the learning process namely scientific approach which can be implemented by using some procedures in the classroom and the textbook.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":240187472,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.31219\/osf.io\/9u6a3","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/osf.io\/9u6a3\/download","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Work in syntactic theory almost universally assumes that hierarchy in syntactic structure is characterized in terms of an abstract primitive relation of dominance. In this paper, we suggest that hierarchy should instead be determined via a primitive c-command relation. This perspective turns out to restrict the range of possible syntactic structures in a linguistically natural way, deriving restrictions on possible configurations that must otherwise be stipulated. Furthermore, we show that a primitive c-command view of syntactic structure provides the basis for a radically simplified conception of adjunction structure, one that not only allows us to understand why the adjunction operation exists alongside substitution, but also explains why these operations have their distinctive structural and derivational properties.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":14674539,"openaccessinfo":{"externalids":{"MAG":"2124680305","ACL":null,"DOI":"10.1111\/1467-9612.00043","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"I compared the strength of bottomup and top-down effects on insect herbivores along a natural salinity gradient in salt marsh communities in West Central, Florida. I used a 2x2 factorial design with plots divided into four different treatments: 1) fertilizer applied to increase plant quality 2) sticky traps added to remove natural enemies (parasitoids) 3) fertilizer applied and sticky traps added and 4) control plots. These plots were placed on 7 different sites containing the salt marsh plant Borrichia frutescens along a natural stress salinity gradient. In each plot I determined the abundance of the sap sucker Pissonotus quadripustulatus, the gall maker Asphondylia borrichiae, spiders and the number of chewed leaves and bored stems. I also recorded leaf area, plant density, plant height and foliar nitrogen. Plants in fertilized plots exhibited increased height, density and leaf area. In fertilized plots, galls were more abundant than in nonfertilized plots (approximately 63% increase), and the same pattern was observed for Pissonotus (55% increase). For chewed leaves and spiders there","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":211559917,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We derive constraints on a possible velocity-dependent DM-nucleon scattering cross section, for Dark Matter in the 10 MeV\u2013100 GeV mass range, using the XQC, DAMIC, and CRESST 2017 Surface Run experiments. We report the limits on cross sections of the form \u03c3=\u03c3vn, for a range of velocity dependencies with n\u220a{-4,-2,-1,0,1,2}. We point out the need to measure the efficiency with which nuclear recoil energy in the sub-keV range thermalizes, rather than being stored as Frenkel pairs in the semi-conductor lattice. The possibility of a significant inefficiency leaves open a considerable \"hole\" in the limits for mass in the \u223c 0.2\u20132 GeV range, which XQC and CRESST can potentially fill when the thermalization efficiency is measured. We call attention to the asymmetry between a conventional lower limit cross section and the \"upper-reach cross section\" imposed by attenuation in an overburden\u2014an upper boundary being extremely sharp but quite insensitive to the statistics of the experiment. Considering the recent interest to use dark matter-baryon interaction with velocity dependence n=-4 to explain the EDGES 21 cm anomaly, we also derive the limits on milli-charged DM that scatters off protons and electrons under a Coulomb-like interaction. We find that much but not all of the region of interest for the EDGES anomaly can be excluded.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118862424,"openaccessinfo":{"externalids":{"MAG":"3102847518","ACL":null,"DOI":"10.1088\/1475-7516\/2018\/10\/007","PubMedCentral":null,"ArXiv":"1804.03073"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/1804.03073","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"To demonstrate morphologically the functional difference in each intestinal part, 27 (starter stage)-and 113 (developer stage)-day-old male Single Comb White Leghorn chickens were fasted for 3 or 7 days. After the end of each fasting period, the villous height and the fine structure of absorptive epithelial calls in the duodenum, jejunum and ileum were compared using light and electron microscopies. On the post-hatching developmental changes of the villous height in the normal control, the duodenum had the highest villi at starter stage followed by undeveloped lower jejunal villi, while the latter showed a marked growth rate up to the developer stage. This explains that the vigorous absorptive part would be mainly the duodenum in early life stage and then extend to the jejunum with increasing age. However, after fasting treatment these proximal intestines had thought to have a high absorptive ability revealed a dramatic reduction of the villous height. This suggests that among the intestinal parts, the higher the intestinal absorptive ability during the normal feeding is, the more rapidly the intestinal villous height is reduced by fasting. In fine structural alterations, the epithelial cells in the duodenum had large lysosomal supranuclear vacuoles even after 3 days fasting. On the other hand, by the first 3 days fasting the jejunal cells showed the lamellar bodies thought as a precursor of vacuoles and had typical vacuoles after next 4 days fasting. These suggest that among the intestinal epithelial cells, the higher the cellular absorptive ability during the normal feeding is, the more rapidly the lysosomal vacuoles grow larger in size by fasting. Compared with the alterations of villous height and ultrastructure of epithelial cells observed in the proximal intestines, the ileum showed an almost constant vilious height and no typical vacuoles but well-developed Golgi apparatuses in cells after fasting. These findings lead to the possibility that the ileum appears to be inactive in absorptive function and it might have another specific function in addition to the conventional absorptive function.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":87153224,"openaccessinfo":{"externalids":{"MAG":"2332437489","ACL":null,"DOI":"10.2141\/JPSA.32.241","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We describe the fabrication of submicron devices on the (011) cleave surface of a GaAs heterostructure crystal, in which this surface is extremely narrow. Special purpose devices are produced, which take advantage of the unique characteristics of cleaved-edge-overgrowth. The successful fabrication relies on understanding the surface tension of the electron beam polymethyl methacrylate resist, the workable degree of variation in resist thickness, and on gluing the crystal onto a backing substrate to increase structural strength. We demonstrate functional gate-controlled quantum point contact constrictions placed 9\u2009\u03bcm from one edge of the cleave surface.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":121449206,"openaccessinfo":{"externalids":{"MAG":"2017370642","ACL":null,"DOI":"10.1063\/1.3694052","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Gold nanoparticles (AuNPs) have been shown to enhance the local radiation dose in tumour mice models. Although AuNPs can be delivered to tumours through enhanced permeability and retention (EPR) effect, delivering of AuNP for therapeutic effect has been proven to be challenging. The application of ultrasound and microbubbles (USMB) has been shown to increase the delivery of genetic material, macromolecules, and chemotherapeutic agents. The hypothesis driving this research is that ultrasound and microbubbles can increase uptake of AuNPs in cells. The results suggest that AuNPs, and USMB aid in its delivery to increase cell death upon irradiation. An improvement of ~ 22 fold was observed with the combined treatment compared to radiation only, implying synergism. In addition, USMB and radiation exhibited an increase in cell death. Cell viability was ~3-4% and is dependent on AuNP concentration, shape and location. Further investigation of this concept was done","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":28408079,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.32920\/ryerson.14649744.v1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.32920\/ryerson.14649744.v1","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Downhill oesophageal varices are venous submucosal dilatations developing in the upper oesophagus, draining upper body venous flow \"downwards\" and usually bypassing superior vena cava obstruction. Extrinsic compression from a thyroid goiter is a rare cause with only 18 cases reported in the literature. We report the case of an 84 year old woman with a long history of multinodular goiter admitted for the exploration of severe iron-deficiency anemia. She had no history of hematemesis or melena. The endoscopic exam found grade II upper oesophageal varices with no sign of active bleeding, as well as a non hemorrhagic gastric ulcer. No other obvious explanation for anemia could be found. Goiter investigation included a cervical and thoracic CT scan which evidenced a voluminous thyroid goiter with massive endothoracic extension, causing oesophageal compression. The optimal treatment was considered to be radioiodine therapy followed by surgery. Downhill oesophageal varices are a rare clinical entity seen in patients with goiter. We propose a clinical observation of this pathology in a patient explored for chronic anemia.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70847383,"openaccessinfo":{"externalids":{"MAG":"1564944645","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The primary cilum is a central component of signalling during neural development, from regional patterning to neuronal differentiation. Here we focus on CROCCP2, a hominid-specific gene duplicate from CROCC (Ciliary Rootlet Coiled Coil), also known as rootletin, that encodes the major protein component of the ciliary rootlet. We find that CROCCP2 is highly expressed in the human fetal brain and not in other primate species. CROCCP2 gain of function in the mouse embryonic cortex results in decreased ciliogenesis, increased mTOR signalling, and increased cell size of radial glial cells, leading to increased generation of intermediate\/basal progenitors and increased neuronal output. CROCCP2 impacts cilia dynamics and neurogenesis by inhibition of the IFT20 ciliary trafficking protein. Our data identify a human-specific protein that drives cortical basal progenitor expansion through modulation of ciliary dynamics.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":261029368,"openaccessinfo":{"externalids":{"MAG":"3036282347","ACL":null,"DOI":"10.1101\/2020.06.17.142976","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/lirias.kuleuven.be\/bitstream\/123456789\/679525\/2\/CROCCP2%20acts%20as%20a%20human-specific%20modifier%20of%20cilia%20dynamics%20and%20mTOR%20signalling%20to%20promote%20expansion%20of%20cortical%20progenitors.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The problem of fast viscous steady Rayleigh-Benard convection in a rectangular enclosure is revisited using asymptotic and numerical methods. There are two generic cases: in the first, there is zero shear stress at all boundaries; in the second, there is zero shear stress at the vertical boundaries, but no slip at the horizontal ones. For the first case, we reconcile our new numerical solutions to the full equations with earlier asymptotic results for large Rayleigh number and effectively infinite Prandtl number. For the second case, we first derive the corresponding asymptotic theory and then reconcile it also with the relevant full numerical solutions. However, the latter also indicate behavior which the asymptotic theory does not predict, for Rayleigh numbers in excess of just over 106 and aspect ratios in excess of around 1.1.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":55278618,"openaccessinfo":{"externalids":{"MAG":"2079289316","ACL":null,"DOI":"10.1063\/1.4829450","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/researchrepository.ul.ie\/articles\/journal_contribution\/Rayleigh-B_nard_convection_at_high_Rayleigh_number_and_infinite_Prandtl_number_asymptotics_and_numerics\/19813879\/1\/files\/35251711.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper evaluates the performance of two prominent on-demand routing protocols, which are Dynamic Source Routing (DSR) and Ad Hoc On-Demand Distance Vector Routing (AODV) for wireless sensor networks. Results obtained from simulations demonstrates that even though DSR and AODV share a similar on-demand behavior, the differences in the protocol mechanics can lead to significant performance differentials. The performance differentials are analyzed using varying network load and network size. Tiny Operating System (TinyOS) is used as a platform for simulating AODV & DSR under various conditions. TinyOS is free software and is designed specially for wireless sensor networks. Wireless Sensor Networks (WSNs) are characterized by multi-hop wireless connectivity, frequently changing network topology and the need for efficient dynamic routing protocols.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":214747816,"openaccessinfo":{"externalids":{"MAG":"1786166294","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This work reports the gold-coated self-organized silicon nanopyramidal array prepared by a wet etching and magnetron sputtering process at room temperature. Scanning electron microscopy was used to detect the morphology of gold films. The surface-enhanced Raman scattering (SERS) spectra of the rhodamine 6G (R6G) molecules adsorbed on a nanoscale gold film were recorded. Experimental results show the relationships between gold film thickness and SERS intensity. A full three-dimensional finite difference time domain calculations were carried out, which compare the experimental results and show agreement with ratios of the SERS enhancement for the different thicknesses of gold films. Furthermore, numerical simulations of the array were conducted for both a real gold metal coating and a perfect electrical conductor to determine whether the SERS enhancement was due to diffraction or plasmonic effects. The sample with the fast fabrication process used in this work could provide a new way to obtain a uniform enhancement and low cost SERS substrate.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":137902010,"openaccessinfo":{"externalids":{"MAG":"2323944265","ACL":null,"DOI":"10.1557\/JMR.2013.352","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Performance appraisals have recently become the focus of legal scrutiny. Because the appraisal process may lead to salary adjustments, promotions, opportunities for development, discipline, or even termination, issues such as fairness and discrimination are raised. This paper discusses specific constitutional and statutory laws that prohibit discrimination in performance appraisals. In addition, specific rulings from select court cases illuminate key legal defense factors in performance appraisal. Questions are posed to help identify weaknesses in a laboratory's performance appraisal system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34259547,"openaccessinfo":{"externalids":{"MAG":"107960046","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Enbridge Pipelines Inc. manages over 1200 liquid hydrocarbon facilities across Canada and the United States, including both mainline facilities and gathering system facilities. The range of facilities managed by Enbridge includes terminals, pump stations, valve sites, scraper trap sites, battery sites, and densitometer sites. Evaluation of risk at facilities is a requirement of 49CFR195 (2) for liquid mainline facilities located in the United States and a requirement of CSA Z662 (3) for NEB regulated mainline facilities in Canada. Enbridge has developed an index risk model that is modular in nature to evaluate risk at various liquid facilities. The index risk model provides a relative risk ranking of facility risk, so the risk values obtained are comparative numbers. Facility risk values may be compared with all facilities within the System, or between similar types of facilities, such as terminals. The modular nature of the facility risk model permits the evaluation of all applicable assets within a given facility. There are three likelihood modules and eight consequence modules within the facility risk model that combine to create a risk value using Equation 1: Risk = Likelihood \u00d7 Consequence (1) The modular indexed risk model has proven to be an effective means of evaluating facility risk. The modular approach meets the requirements of 49CFR195 and the Onshore Pipeline Regulations (OPR 1999) that references CSA Z662 for the risk assessment of facilities associated with mainline pipe. The modular approach can be applied to all facilities regardless of regulatory requirements and can assist in the prioritization of risk control strategies at facilities. As this approach provides a whole risk view of facilities rather than focusing solely on leaks and spills, the risk model may identify systemic areas of opportunity within the organization. This paper provides a review of the development of a modular index facility risk model for liquid operations. Challenges and successes faced during the development and execution of the model are discussed.Copyright \u00a9 2008 by ASME","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":109582988,"openaccessinfo":{"externalids":{"MAG":"1983312384","ACL":null,"DOI":"10.1115\/IPC2008-64344","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Wireless Sensor Network (WSN) are the emerging and challenging technology with low processing and battery power. Security becomes a major issue in WSN; because of its wireless nature it is prone to various types of attacks and losing of data packet. Secure routing is important to avoid this type of issues. They are many techniques are available to provide secure routing to WSN. In the proposed work, our main aim is to find the trusted node and routing is done through the node to provide secure routing. The trusted node is identified by using MAC model and it is rated. And also giving the un trusted node a chance to relay prove its identity. It provides the security features with minimum overhead and energy efficiency.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1418957,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intestinal health of weaning piglets was studied after oral treatments with fosfomycin (FOS), Cynara scolymus extract (CSE), deoxynivalenol (DON) and their combinations. Piglets were divided in groups and received different treatments during 15 days, namely DON (1mg\/kg of feed), FOS administered into the drinking water (30 mg\/kg b.w.), CSE (300 g\/ton of feed) and all possible combinations including a control group that received clean balanced diet. At day 15, three piglets from each group were euthanized and gastrointestinal tract samples were immediately taken to evaluate pH, bacteriology (enterobacteria and lactic acid bacteria), volatile fatty acids concentration (VFAs), disaccharidases activity (lactase, sucrase and maltase), histology (intestinal absorptive area [IAA] and goblet cells count) and adherence of bacteria to intestinal mucus. Animals receiving FOS and CSE treatments exhibited evident beneficial intestinal effects compared to animals receiving diets free from these compounds. This was revealed by a lower enterobacteria population together with a lower E\/L, an enhanced production of butyric acid, an increased enzymatic activity (particularly maltase), and a greater IAA and goblet cells count along with an increase in pathogenic bacteria adherence to intestinal mucus. Interactions between both treatments resulted in similar beneficial effects as their individual administration. On the contrary, DON produced detrimental effects on intestinal health as a decrease was observed on volatile fatty acids production, enzymatic activity and goblet cells count in animals receiving diets containing sub- toxic concentrations of this mycotoxin. The knowledge of the intestinal effects of these compounds contributes to understand the physiological and pathological gut changes and their potential productive consequences.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":261333541,"openaccessinfo":{"externalids":{"MAG":"2804817766","ACL":null,"DOI":"10.1101\/323204","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1016\/j.aninu.2019.08.001","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The development and subsequent operation of the Shuttle as America's primary space transportation system is the culmination of several decades of research, technology application and engineering. This vast endeavour, which has enjoyed unprecedented success to date, is one of the great team efforts in our technological history. From the pioneering efforts of Goddard and Tsiolkovsky, the critical contributions of von Karman, the insight of Faget, and the dedicated efforts of a multitude of others, the Shuttle has become a reality. The initial phases of Shuttle development involved extensive analysis and testing with margins carefully engineered to provide for technical contingencies, and operational results have verified the elegance of the design. Though its capability to carry cargo has received the most attention, the Shuttle's capabilities in orbit will undoubtedly play a key role in the development of entirely new technologies and associated industries peculiar to the space environment. This paper will discuss the evolution of the Shuttle system and postulate its future contributions to the industrialization of space.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":124482933,"openaccessinfo":{"externalids":{"MAG":"2324403284","ACL":null,"DOI":"10.1098\/rsta.1984.0053","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In contemporary world there are a lot of idea of dignity and we can observe many differences in the perception and interpretation of it. One can find many reasons for this discrepancy. While focusing on the most important human rights, the authors want to demonstrate that, despite the many changes that have occurred in recent decades, the idea of human rights is essential to human dignity. For these reasons, we believe that the nature of human rights require its re-examination in the prism of human dignity. Analysis of philosophical, cultural and legal contexts in which a concept of dignity occurs, may contribute to a better understanding of what dignity is and what is not. Above all, may allow reflection on the crisis of dignity of the XXI century human. Dignity is a type of value that co-creates the sense of human life, directs to a specific goal, and also regulates interpersonal connections. Here, the authors analyze dignity in the context of specific concepts of man to show the relations between dignity and the eternal question: \"who am I in the light of my rights?\" Secondarily, we show how crucial contextual and hermeneutical thinking is, while studying fundamental concepts of human experiences such as dignity. The analysis of the subject carried out by experts in fields of legal and philosophical sciences, based on the common foundation, which is an individual and his life, points to many critical issues that need to be thoroughly evaluated, as long as the subject is approached holistically.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55509386,"openaccessinfo":{"externalids":{"MAG":"2407647967","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aggressive and unpredictable behavior of relapsed T-cell acute lymphoblastic leukemia (T-ALL) presents a major clinical challenge, with >70% of children and >90% of adults unable to survive relapsed disease. Relapsed T-ALL often acquires mutations that are not found in the primary malignancy. It is these new mutations that allow clones to survive treatment and drive relapse growth. In order to identify the genes and pathways responsible for T-ALL relapse, we have developed a transgenic zebrafish model of relapsed T-ALL where single fluorescently-labeled leukemic cells are transplanted into genetically identical recipient fish and functionally assessed for differences in relapse growth. Using serial transplantation of single T-ALL cells and >6,000 recipient animals, we have followed single-cell evolution of T-ALL and identified critical drivers of relapse. These experiments showed that 6 of 49 individual T-ALL cells significantly increased their ability to form relapse over time. Analysis of T-ALL clones pre- and post-evolution showed that AKT pathway activation was correlated with increased relapse potential. Subsequent studies utilizing transgenic zebrafish that over-expressed activated AKT in developing T-ALL demonstrated that AKT signaling increased relapse potential 10-fold. Transgenic epistatic experiments revealed that AKT signaling plays two distinct roles in T-ALL relapse: the AKT\/mTORC1 pathway directly enhanced relapse potential, while AKT mediated stabilization of the Myc protein increased T-ALL aggressiveness. Moreover, small molecule inhibition of AKT signaling reduced T-ALL relapse potential in vivo by 25-fold and synergized with Dexamethasone, a common cytotoxic chemotherapy, to significantly enhance cell killing in both zebrafish and human T-ALL. Activation of AKT signaling is associated with poor prognosis and drug resistance in human T-ALL, which, together with our work, suggests that AKT will be a useful molecular target in the treatment of T-ALL. Our experiments have documented the functional heterogeneity of single leukemic cells and identified AKT as a critical driver of T-ALL aggression, relapse formation, and insensitivity to therapy. These are first studies performed in any model to follow single cell evolution as it relates to relapse, opening new and exciting avenues of study to uncover genetic pathways that drive cancer malignancy. Citation Format: Jessica S. Blackburn, Sali Liu, Kimberly Dobrinski, Jayme Ranalli, Sarah Martinez, Charles Lee, David Langenau. Single cell evolution of AKT pathway activation drives T-cell acute lymphoblastic leukemia relapse. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3805. doi:10.1158\/1538-7445.AM2013-3805","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":75826014,"openaccessinfo":{"externalids":{"MAG":"2326606528","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-3805","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nThe present study aimed to quantitatively evaluate the accuracy of the edentulous maxillomandibular relationship record for diagnostic complete dentures fabricated using computer-aided design (CAD) and three-dimensional (3D) printing.\n\n\nMETHODS\nSix edentulous patients were enrolled. The maxillomandibular relationship obtained from diagnostic complete dentures (DiaCD test group), that obtained from complete dentures with artificial teeth in the intercuspal position (CD control group), and the centric relationship acquired by gothic arch tracing (CR standard group) were recorded, and 3D surface scanning was performed on these records. Using the CR standard group as a reference, the DiaCD test and CD control group displacements were measured in the horizontal antero-posterior, horizontal right-and-left, and vertical directions. The displacements for the DiaCD test group were compared with those for the CD control group using the Wilcoxon matched-pairs signed rank test.\n\n\nRESULTS\nIn terms of centric relationship, the 95% confidence interval of displacement in the horizontal antero-posterior direction was (0.54-1.89) mm in the DiaCD test group and (0.32-1.34) mm in the CD control group. The inter-group difference was significant (P = 0.03).\n\n\nCONCLUSION\nIt is feasible to record the edentulous maxillomandibular relationship using diagnostic complete dentures fabricated by CAD\/3D printing, but the protrusion of edentulous patients should not be neglected.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":245465298,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2334\/josnusd.21-0382","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.jstage.jst.go.jp\/article\/josnusd\/64\/1\/64_21-0382\/_pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Beat-wave acceleration of particles requires that the particle trajectories closely follow the constant-phase lines of the excited plasma wave. Dephasing phenomena caused by plasma inhomogeneities and by relativistic frequency shifts and the accompanying self-phase modulation of the plasma wave are investigated. Parameter studies of beat-wave experiments indicate the plasma homogeneity will be a critical issue, especially with short wavelength lasers. The plasmon wake suffers most strongly from dephasing effects which fact considerably reduces the efficiency of the wake region in beat-wave acceleration.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":121098350,"openaccessinfo":{"externalids":{"MAG":"2054276394","ACL":null,"DOI":"10.1088\/0031-8949\/39\/6\/011","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Simplexides constitute a unique group of immunosuppressive glycolipids that demonstrate antiproliferative activities against activated T-cell lymphocytes via a unique non-cytotoxic inhibition. To investigate the structure-activity relationship of the varied long-chain secondary alcohols on simplexides, we developed an efficient and divergent route to the synthesis of simplexides and congeners, taking advantage of a late-stage olefin cross-metathesis reaction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37688715,"openaccessinfo":{"externalids":{"MAG":"2475134655","ACL":null,"DOI":"10.1039\/c3ob40552d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Transforming database schemas into an ontology language opens the door wide to the many advantages offered by the Semantic Web. Industries in particular can benefit from intelligent systems (e.g., decision-support systems) arising from such transformations. In this paper, we propose a semi-automated algorithm to transform data to the ontology language, OWL, while taking advantage of the actual data stored in a database schema. These data are used to discover hidden patterns in a database schema with a minimal level of human involvement. Such an approach also ensures improved mappings for relatively loosely structured database schema. The evaluation results on a simple DBLP database schema show improved effectiveness of such transformations.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1,"unknown":3}},"corpusid":17825540,"openaccessinfo":{"externalids":{"MAG":"2120927097","ACL":null,"DOI":"10.1109\/CCECE.2011.6030595","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The advanced Temperature and Stress Test Machine was introduced to evaluate the cracking resistance of concrete with inclusion of light-burnt MgO under full restraint by tracking thermal and deformation development. Results showed that light-burnt MgO being incorporated ranging between 4 per cent and 6 per cent by mass of cementitious materials was beneficial to increase the maximum compressive stress and cracking stress of concrete by 0.37MPa and 0.2MPa on average respectively. The maximum temperature was slightly reduced from 59.8\u00b0C to 66.2\u00b0C while cracking temperature was significantly decreased from 0.8\u00b0C to minus 5.6\u00b0C. Sensitive anti-cracking coefficient F was forwarded to assess the early cracking tendency of concrete and in general, inclusion of 4 per cent light-burnt MgO with activity of 109s was rated the best in crack resistance.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":135759174,"openaccessinfo":{"externalids":{"MAG":"2030534668","ACL":null,"DOI":"10.4028\/www.scientific.net\/AMR.168-170.1348","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The K-matrix formalism has been applied to the charm sector for the .rst time in the FOCUS Dalitz plot analyses of the Ds+ and D+ \u2192 \u03c0+\u03c0\u2212\u03c0+ final states. The results, presented here, are extremely encouraging since the same K-matrix description provides a coherent picture of both two-body scattering measurements in light-quark experiments as well as charm meson decay. Such a result was not obvious beforehand. Moreover, the non-resonant component of each decay appears to be described by known two-body S-wave dynamics, without the need to include any three-body constant amplitude contribution.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250664750,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1742-6596\/9\/1\/031","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.1088\/1742-6596\/9\/1\/031\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A medium was developed which permitted isolation, apparently for the first time, of the bacteria responsible for the acid production in the 100-year-old San Francisco sour dough French bread process. Some of the essential ingredients of this medium included a specific requirement for maltose at a high level, Tween 80, freshly prepared yeast extractives, and an initial pH of not over 6.0. The bacteria were gram-positive, nonmotile, catalase-negative, short to medium slender rods, indifferent to oxygen, and producers of lactic and acetic acids with the latter varying from 3 to 26% of the total. Carbon dioxide was also produced. Their requirement for maltose for rapid and heavy growth and a proclivity for forming involuted, filamentous, and pleomorphic forms raises a question as to whether they should be properly grouped with the heterofermentative lactobacilli.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":43181156,"openaccessinfo":{"externalids":{"MAG":"1514442679","ACL":null,"DOI":"10.1128\/am.21.3.459-465.1971","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/aem.asm.org\/content\/aem\/21\/3\/459.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"A pressure flow meter system was newly developed for measuring hydraulic characteristics of plant organs. In the system, the pressurized water flow through plant organs was given at a desired rate by regulating the applied pressure, and hydraulic resistance or conductance of plant organs was determined from the flow rate and the applied pressure at intervals of about 5 minutes. By applying the system, individual evaluations of hydraulic characteristics of node, internode and leaf insertion in a nodal complex were performed on the basis of an analogue circuit of hydraulic resistances, where the hydraulic resistance of the node was divided into halves at the leaf insertion point. From measurements with Epipremnum aureum Bunt., Cucumis sativus L. and Zea mays L., it was indicated that hydraulic conductance of a leaf insertion was significantly lower than those of node and internode. Z. mays with the thickest stem had the highest hydraulic conductance of the internode. On the other hand, the stem-area specific hydraulic conductances of node and internode were the highest in C. sativus with the thinnest stem and the large leaf.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":56035696,"openaccessinfo":{"externalids":{"MAG":"2112055275","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A unique iron-catalyzed oxidative diamination of nitroalkene with 2-aminopyridine for the synthesis of 2-nitro-3-arylimidazo[1,2-a]pyridines with complete regioselectivity has been achieved under mild and aerobic reaction conditions. This is the first method for the synthesis of 2-nitroimidazo[1,2-a]pyridines. These scaffolds were also synthesized directly from styrenes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":44866394,"openaccessinfo":{"externalids":{"MAG":"2953249601","ACL":null,"DOI":"10.1021\/ol502218u","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"60Co is a fission product of 235U and represents a risk of internal exposure of workers in nuclear power plants, especially those involved in the maintenance of potentially contaminated parts and equipment. The control of 60Co intake by inhalation can be performed through in vivo monitoring. This work describes the evaluation of a technique through the minimum detectable activity and the corresponding minimum detectable effective doses, based on biokinetic and dosimetric models of 60Co in the human body. The results allow to state that the technique is suitable either for monitoring of occupational exposures or evaluation of accidental intake.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":114999527,"openaccessinfo":{"externalids":{"MAG":"2487160886","ACL":null,"DOI":"10.1088\/1742-6596\/733\/1\/012089","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/733\/1\/012089","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Copper-catalyzed regioselective quadruple borylation of terminal alkynes has been developed employing a copper catalyst generated from CuI and dcpe (1,2-bis(dicyclohexylphosphino)ethane). A wide range of terminal alkynes undergo this multi-borylation reaction to afford the corresponding 1,1,2,2-tetraborylalkanes in high yields. Mechanistic studies reveal that this quadruple borylation reaction proceeds through copper-catalyzed sequential double 1,2diborylation of alkynes and 1,2-diborylalkene intermediates. This protocol represents the most straightforward and atom-economic approach to prepare sp3-tetra-organometallic reagents from readily accessible alkynes with commercially available copper catalysts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252567353,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1002\/anie.202213057","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Free glucose concentration and polysaccharide production in Clostridium butyricum cells have been studied with an enzymatic method. Results indicated a substantial decrease in intracellular glucose content simultaneously with a production of polysaccharide prior to the end of exponential growth. Then the polysaccharide accumulated rapidly to reach a maximum just before the first refractile spores appeared, and it decreased by 50% during the last stages (V and VI) of sproulation. Electron micrographs of ultrathin sections have demonstrated that most of the polysaccharide is located inside the mother cell cytoplasm as large granules when the remaining is dispersed within the spore cytoplasm beginning during stage III of the sporulation. Overall results showed that production and use of C. butyricum polysaccharide were closely related to sporulation. The isolated polysaccharide exhibited poor water solubility, iodine spectrum with a lambda max at 545 nm and 72% beta-amylolysis. Total hydrolysis occurred with amyloglucosidase indicating an alpha-glucan containing alpha(1 leads to 4) and alpha(1 leads to 6) glucose linkages. The debranching from its beta-dextrin limit by pullulanase revealed the presence of a glycogen like-type structure with some external chains which are longer than those of a normal glycogen. This glycogen arrangement appeared to be of clusters linked by linear chains at least as long as the longest external chains.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24442302,"openaccessinfo":{"externalids":{"MAG":"2417062644","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Medical augmented reality has undergone much development recently. However, there is a lack of studies quantitatively comparing the different display options available. This paper compares the effects of different graphical overlay systems in a simple micromanipulation task with \"soft\" visual servoing. We compared positioning accuracy in a real-time visually-guided task using Micron, an active handheld tremor-canceling microsurgical instrument, using three different displays: 2D screen, 3D screen, and microscope with monocular image injection. Tested with novices and an experienced vitreoretinal surgeon, display of virtual cues in the microscope via an augmented reality injection system significantly decreased 3D error (p <; 0.05) compared to the 2D and 3D monitors when confounding factors such as magnification level were normalized.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13985782,"openaccessinfo":{"externalids":{"MAG":"2047174214","ACL":null,"DOI":"10.1109\/EMBC.2012.6346203","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Cisplatin (CIS) is one of the widely used anticancer drugs. Despite its high efficiency in the treatment of testicular cancer, CIS has severe adverse effects on spermatogenesis and may even lead to infertility. Propolis is a honeybee product. It has free-radical scavenging activity. Aim To evaluate the possible protective effect of bee propolis on CIS-induced testicular damage in adult male albino rats using histological, immunohistochemical, and morphometric studies. Materials and methods Twenty-four adult male albino rats were divided into four groups, each group including six rats: control, propolis (100 mg\/kg, orally daily for 7 days), CIS (10 mg\/kg by a single intraperitoneal injection and left for 5 days without treatment), and combined therapy (propolis 7 days before CIS injection and continued for 5 days after). Testicular weights were measured. Histological (using H&E and Masson's trichrome stains) and immunohistochemical [using nuclear factor-&kgr;B (NF-&kgr;B)\/p65 and claudin 11] studies were carried out. Morphometric measurements of seminiferous tubule diameter, area% of collagen fibers, and claudin 11, in addition to the optical density of NF-&kgr;B\/p65, were carried out, followed by statistical analysis. Results Testicular weight decreased significantly in the CIS group. CIS induced distorted seminiferous tubules, cellular disorganization, wide separation of intertubular space, cytoplasmic vacuolation, and pyknotic nuclei. Increased area% of collagen fibers, increased optical density of NF-&kgr;B\/p65 immunoreactivity, and decreased area% of claudin 11 immunoexpression were found in the spermatogenic cells. The combined therapy group showed a significant reduction in histological, immunohistochemical, and morphometric changes. Conclusions A significant role of NF-&kgr;B activation was found in CIS-induced testicular damage. Blockade of NF-&kgr;B activation by propolis could be an effective strategy for protection from CIS-induced testicular damage, provided it is administered orally early enough before the administration of CIS. It also prevented the disruption of tight junction protein, claudin 11; thus, it could preserve blood\u2013testis barrier function.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":87350558,"openaccessinfo":{"externalids":{"MAG":"2332065927","ACL":null,"DOI":"10.1097\/01.EHX.0000423875.22012.efb","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"CYLCH YR YNYS translated here as 'Circle of the Island' takes as its subject the island of Skokholm off the west Wales coast. One of a small group of bird sanctuaries, this particular site of special scientific interest supports one of the main breeding grounds of the Manx Shearwater, Storm Petrel and Auks. Lying in that region termed 'Little England Beyond Wales', the name Skokholm indicates the complex history of successive cultural invasions including that of the Scandinavians in the 8th century. Islands carry projections of 'Paradise', an idealisation often at odds with the daily reality of survival. From Skokholm looking west over the Atlantic, the tiny island of Grassholm lies white on one side, glistening white with Gannets. It is purported to be the island referred to in the Mabinogion as 'Gwales'. There Pryderi and his men spent eighty years in love with feasting and dancing until one of his men opened the forbidden door. They became conscious of their worldly tasks and passed from mythic to historical time through an act of remembrance: 'cofio'. Images filmed during the passing seasons of '91 reveal changes in vegetation and bird life observed through a repetition of viewpoints. The text refers to this breaking of myth through the acts of looking and listening.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":130141935,"openaccessinfo":{"externalids":{"MAG":"2261075077","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND AND PURPOSE\nMany patients with acute stroke are excluded from receiving thrombolysis agents within the necessary time limit (3 or 6 hours from stroke onset) because they or their family members are unable provide the time of stroke onset. Brain tissue sodium concentration ([Na(+)]) increases gradually and incessantly during the initial hours of experimental focal cerebral ischemia but only in severely damaged brain regions. We propose that this steady increase in [Na(+)] can be used to estimate the time after arterial occlusion in the rat middle cerebral artery occlusion model of ischemic stroke.\n\n\nMETHODS\nSixteen anesthetized Sprague-Dawley rats underwent permanent middle cerebral artery occlusion combined with bilateral common artery occlusion. After 100 to 450 minutes, diffusion-weighted MRI was used to generate apparent diffusion coefficient (ADC) maps, cerebral blood flow (CBF) was determined with (14)C-iodoantipyrine (in a subset of 7 animals), and the brain was frozen. Autoradiographic CBF sections and punch samples for Na(+) analysis were obtained from the brain at the same level of the MR image. Severely at risk regions were identified with an ADC of <520 microm(2)\/s and, in the subset, with both ADC of <520 microm(2)\/s and CBF of <40 mL. 100 g(-1). min(-1).\n\n\nRESULTS\nBoth CBF and the ADC dropped quickly and remained stable in the initial hours after ischemic onset. Linear regression revealed strong linearity between [Na(+)] and time after onset, with a slope of 0.95 or 1.00 (mEq\/kg DW)\/min, with both ADC and ADC-plus-CBF criteria, respectively. The 95% CIs at 180 and 360 minutes were between 41 and 52 minutes.\n\n\nCONCLUSIONS\nThe time after ischemic onset can be estimated with this 2-step process. First, ADC and CBF are used to identify severely endangered regions. Second, the [Na(+)] in these regions is used to estimate time after onset. The favorable 95% CIs at the time limits for thrombolytic therapy and the availability of measurements of ADC, CBF, and [Na(+)] in humans through the use of MRI suggest that this time-estimation scheme could be used to assess the appropriateness of thrombolysis for patients who do not know when the stroke occurred.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":8787930,"openaccessinfo":{"externalids":{"MAG":"1498806602","ACL":null,"DOI":"10.1161\/01.STR.31.6.1386","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study explores whether female economic inclusion enhances tax performance in a sample of 48 countries in Sub-Saharan Africa from 2000 to 2018. The study's empirical evidence is based on the generalized method of moments in order to account for endogeneity concerns. Three tax performance measurements are used, notably, total taxes revenue excluding social contributions, reported tax revenue derived from natural resources sources, and total non-resource tax revenue. Three female inclusion indicators are used, namely, female employment in industry, female labour force participation, and female employment. The following empirical evidences are documented; (i) There is a negative net effect from the enhancement of female employment in the industry on the total tax revenue. (ii) There is a positive net effect of female employment in the industry on the non-resource taxes. An extended threshold analysis is performed to establish the critical masses that could further influence tax performance positively. The following thresholds are established. (i) a minimum of 15.35 \"employment in industry, female (% of female employment)\" for the total tax revenue and (ii) a maximum of 23.75 \"employment in industry, female (% of female employment)\" for the non-resource tax revenue. These critical masses are crucial for sustainable development because, below or beyond these thresholds, policy makers should complement the female economic inclusion with other economic measures designed to improve tax performance in Sub-Saharan Africa.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264876916,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Our research focuses on combining the valuable properties of silk fibroin (SF) and calcium phosphate (CaP). SF is a natural protein with an easily modifiable structure; CaP is a mineral found in the human body. Most of the new age biocomposites lack interaction between organic\/inorganic phase, thus SF\/CaP composite could not only mimic the natural bone, but could also be used to make drug delivery systems as well, which can ensure both healing and regeneration. CaP was synthesized in situ in SF at different pH values, and then crosslinked with gelatin (G), horseradish peroxide (HRP), and hydrogen peroxide (H2O2). In addition, dexamethasone phosphate (DEX) was incorporated in the hydrogel and drug delivery kinetics was studied. Hydrogel made at pH 10.0 was found to have the highest gel fraction 110.24%, swelling degree 956.32%, and sustained drug delivery for 72 h. The highest cell viability was observed for the hydrogel, which contained brushite (pH 6)\u2014512.43%.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-26":1,"unknown":2}},"corpusid":244818255,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/ma14237191","PubMedCentral":"8658330","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1944\/14\/23\/7191\/pdf?version=1638234075","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The issue of personnel assessment on the basis of situational approach is actualized. The special attention is given to the improvement of application of this approach to personnel assessment in an organization.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":112496265,"openaccessinfo":{"externalids":{"MAG":"2271294031","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recommenders have become a fundamental tool to navigate the huge amount of information available on the web. However, their ubiquitous presence comes with the risk of exposing sensitive user information. This paper explores this problem in the context of user-based collaborative filtering. We consider an active attacker equipped with externally available knowledge about the interests of users. The attacker creates fake identities based on this external knowledge and exploits the recommendations it receives to identify the items appreciated by a user. Our experiment on a real data trace shows that while the attack is effective, the inherent similarity between real users may be enough to protect at least part of their interests.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":13894475,"openaccessinfo":{"externalids":{"MAG":"1964989819","ACL":null,"DOI":"10.1145\/2751323.2751328","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/hal.inria.fr\/hal-01158723\/file\/main_document%20%281%29.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Using spillover and crossover theory, we examined how subordinate's experience of abusive supervision impacts both subordinate's and partner's family domains. Specifically, a model was proposed and tested that examined the fallout from abusive supervision through 2 types of strain, work-to-family conflict and relationship tension, on family satisfaction of the subordinate and on family functioning of the partner. Using a matched set of 280 subordinates and partners, this study found that abusive supervision contributes to the experience of work-to-family conflict and relationship tension. Further, family satisfaction for the subordinate and family functioning for the partner were diminished through the experience of relationship tension. Interestingly, although the experience of work-to-family conflict contributed to relationship tension, it did not directly impact the family outcomes. We discuss the study's implications for theory, research, and practice while suggesting new research directions.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":146165847,"openaccessinfo":{"externalids":{"MAG":"2168937487","ACL":null,"DOI":"10.1111\/J.1744-6570.2011.01232.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Improving learning efficiency is paramount for learning resource allocation with deep neural networks (DNNs) in wireless communications over highly dynamic environments. Incorporating domain knowledge into learning is a promising approach to dealing with this issue. It is also an emerging topic in the wireless community. In this article, we briefly summarize two approaches for using domain knowledge: introducing a mathematical model and prior knowledge to deep learning. Then, we consider a type of symmetric prior permutation equivariance, which widely exists in wireless tasks. To explain how such a generic prior is harnessed to improve learning efficiency, we resort to ranking, which jointly sorts the input and output of a DNN. We use power allocation among subcarriers, probabilistic content caching, and interference coordination to illustrate the improvement of learning efficiency by exploiting the property. From the case study, we find that the required training samples to achieve given system performance decreases with the number of subcarriers or contents, owing to an interesting phenomenon called \"sample hardening.\" Simulation results show that the training samples, the free parameters in DNNs, and the training time can be reduced dramatically by harnessing the prior knowledge. The samples required to train a DNN after ranking can be reduced by 15 \u223c 2,400 folds to achieve the same system performance as the counterpart without using prior.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":243986130,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/mwc.003.21003437","PubMedCentral":null,"ArXiv":"2005.08510"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/2005.08510","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"A fascinating new study in which John McAleer explores the maritime gateway to Asia around the Cape of Good Hope and its critical role in the establishment, consolidation and maintenance of the British Empire in the late eighteenth and nineteenth centuries. Situated at the centre of a maritime chain that connected seas and continents, this gateway bridged the Atlantic and Indian Oceans, which, with its commercial links and strategic requirements, formed a global web that reflected the development of the British Empire in the period. The book examines how contemporaries perceived, understood and represented this area; the ways in which it worked as an alternative hub of empire, enabling the movement of people, goods, and ideas, as well as facilitating information and intelligence exchanges; and the networks of administration, security and control that helped to cement British imperial power.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":132008775,"openaccessinfo":{"externalids":{"MAG":"2429462688","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper argues that fear is a powerful factor of user experience, which is likely to have a general effect on utility and usability of interactive technologies. Currently interaction design lacks methods and concepts, which would allow the field to properly understand - and deal with - users' fears. The paper presents a tentative exploration of the aims, challenges, and strategies of addressing users' fears in interaction design.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":110343620,"openaccessinfo":{"externalids":{"MAG":"2211586747","ACL":null,"DOI":"10.14236\/EWIC\/CREATE2010.13","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Coastal communities have long gathered seaweeds for their own consumption, for animal feed and for fertilizer. The development of industrial use and trade of seaweeds generated income to local communities. The intensification of the exploitation led local communities to implement rules to regulate harvesting. This paper analyses the evolution of seaweed management regimes in four countries: France, Japan, Chile and Norway. Social justice within the communities and equity among gatherers appear to be the basic principles to these rules. Conflict avoidance is their concern much more than resource conservation. This review highlights the role played by fishers' organisations and the processing industries in the management of seaweeds.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":131725104,"openaccessinfo":{"externalids":{"MAG":"2278761772","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The specific neurotropic action of rimantadine was demonstrated in mollusk neuron experiments. No specific neurotropic activity of dejtiphorin was found. In combined application, the latter blocked the neurotropic effect of rimantadine. In experiments in white mice and rats, high doses of both drugs decreased the emotional and motor activity of the animals. After the use of the combination of the two drugs the activity of the animals did not differ significantly from that in the controls. The antiviral effect of each drug alone and of combination thereof was similar.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":89534541,"openaccessinfo":{"externalids":{"MAG":"2415599745","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Across Europe universities are expected to work more closely with employers to ensure that learners develop employability skills for the workplace. Policy discourse suggests that a closer relationship between universities and employers can act as a mechanism to develop employability skills more effectively. This article draws on a small qualitative case study which investigated the \"Graduate@ Work\" initiative undertaken by the Open University. These distance learners, sponsored by their SME employers, were already working and the research investigated employer and student understandings of the connections between employability skills, working and learning and whether facilitating a closer relationship between the university and employers would enable more effective learning in relation to the workplace.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":154952484,"openaccessinfo":{"externalids":{"MAG":"2147490906","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Peripheral nerve injury gives rise to devastating conditions including neural dysfunction, unbearable pain and even paralysis. The therapeutic effect of current treatment for peripheral nerve injury is unsatisfactory, resulting in slow nerve regeneration and incomplete recovery of neural function. In this study, nerve suture combined with ADSCs injection was adopted in rat model of sciatic nerve injury. Under real-time visualization of the injected cells with the guidance of NIR-II fluorescence imaging in vivo, a spatio-temporal map displaying cell migration from the proximal injection site (0 day post-injection) of the nerve to the sutured site (7 days post-injection), and then to the distal section (14 days post-injection) was demonstrated. Furthermore, the results of electromyography and mechanical pain threshold indicated nerve regeneration and functional recovery after the combined therapy. Therefore, in the current study, the observed ADSCs migration in vivo, electrophysiological examination results and pathological changes all provided robust evidence for the efficacy of the applied treatment. Our approach of nerve suture combined with ADSCs injection in treating peripheral nerve injury under real-time NIR-II imaging monitoring in vivo added novel insights into the treatment for peripheral nerve injury, thus further enhancing in-depth understanding of peripheral nerve regeneration and the mechanism behind.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235813553,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fchem.2021.676928","PubMedCentral":"8317167","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.3389\/fchem.2021.676928","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Objectives: There have been several reports on different prostate cancer screening tests, which may improve the specificity in the early detection of prostate cancer. Cut-off values of these tests are mainly based on data from USA and Europe and may not be applicable to other races. We conducted this study to evaluate the utility of different screening tests for detecting prostate cancer in Iranian men. Patients and Methods: Between March 2007 and March 2008, 187 men with total prostate specific antigen (PSA) in the range of 2 to 20ng\/ml and with no pretreatment of the prostate, underwent transrectal ultrasound guided prostatic biopsy for suspected prostate cancer. The diagnostic value of total PSA levels, the free to total PSA ratio (f\/t PSA) and PSA density (PSAD) were compared using receiver operating characteristic curve analysis. Results: Prostate cancer was diagnosed in 101 (54.0%) of the 187 patients. There were significant differences between the groups in the age and all PSA related parameters. Areas under the curve of PSAD and f\/t PSA were higher than that of total PSA indicating a better diagnostic accuracy. We also noted a significantly better performance for PSAD compared with f\/t PSA in a subgroup of patients with total PSA between 2 and 10 ng\/ml. Conclusion: PSAD was a better predictor of prostate cancer especially in men with PSA levels < 10 ng\/ml.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":72320901,"openaccessinfo":{"externalids":{"MAG":"2029246148","ACL":null,"DOI":"10.1159\/000253399","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1159\/000253399","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to investigate the possible protective role of lycopene, as a natural antioxidant and anticancer, against hepatotoxicity induced by administration of flutamide (10, 100, and 300 mg\/kg) for 60 days in male Wistar albino rats (Rattus rattus). Obtained results showed significant increase in malondialdehyde (MDA), the marker of lipid peroxidation; marked decreases in the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), the major antioxidant markers, in the liver of rats treated with flutamide. The drug also markedly lowered serum contents of total proteins (TP), albumin (ALB) and high density lipoprotein-cholesterol (HDL-C) in treated rats. On the other hand, activities of alanine aminotransferase (ALT), aspartate amino-transferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH); and levels of total bilirubin (TB), total lipid (TL), total cholesterol (TC), triglycerides (TG), and low density lipoprotein-cholesterol (LDH-C) in serum were elevated. Flutamide-induced adverse effects were dose-dependent, and suggested incidence of oxidative tissue damage in the liver of used rats. However, treatment with lycopene (10 mg\/kg) markedly reduced the deleterious effects of flutamide on the investigated parameters, particularly in low dose-treated rats. Lycopene treatment alone at applied dose level seemed to be safe, non-toxic to the monitored biochemical indices. These data indicate that the natural antioxidant lycopene may has a protective effect against flutamide-induced hepatotoxicity in male R. rattus. Further studies are needed to investigate the hepatoprotective effect of lycopene during therapy with flutamide in patients with prostate cancer.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":78199243,"openaccessinfo":{"externalids":{"MAG":"2589040294","ACL":null,"DOI":"10.5455\/egyjebz.20170202100538","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Development of drug resistance is an inevitable phenomenon in castration-resistant prostate cancer (CRPC) cells requiring novel therapeutic approaches. In this study, efficacy and toxicity of Rhizochalinin (Rhiz) \u2013 a novel sphingolipid-like marine compound \u2013 was evaluated in prostate cancer models, resistant to currently approved standard therapies. In vitro activity and mechanism of action of Rhiz were examined in the human prostate cancer cell lines PC-3, DU145, LNCaP, 22Rv1, and VCaP. Rhiz significantly reduced cell viability at low micromolar concentrations showing most pronounced effects in enzalutamide and abiraterone resistant AR-V7 positive cells. Caspase-dependent apoptosis, inhibition of pro-survival autophagy, downregulation of AR-V7, PSA and IGF-1 expression as well as inhibition of voltage-gated potassium channels were identified as mechanisms of action. Remarkably, Rhiz re-sensitized AR-V7 positive cells to enzalutamide and increased efficacy of taxanes. In vivo activity and toxicity were evaluated in PC-3 and 22Rv1 NOD SCID mouse xenograft models using i.p. administration. Rhiz significantly reduced growth of PC-3 and 22Rv1 tumor xenografts by 27.0% (p = 0.0156) and 46.8% (p = 0.047) compared with controls with an increased fraction of tumor cells showing apoptosis secondary to Rhiz exposure. In line with the in vitro data, Rhiz was most active in AR-V7 positive xenografts in vivo. In animals, no severe side effects were observed. In conclusion, Rhiz is a promising novel marine-derived compound characterized by a unique combination of anticancer properties. Its further clinical development is of high impact for patients suffering from drug resistant prostate cancer especially those harboring AR-V7 mediated resistance to enzalutamide and abiraterone.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3307567,"openaccessinfo":{"externalids":{"MAG":"2511849203","ACL":null,"DOI":"10.18632\/oncotarget.11941","PubMedCentral":"5342509","ArXiv":null},"license":null,"url":"http:\/\/www.oncotarget.com\/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11941&path%5B%5D=37800","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract\u2014 Pig skin has been shown to have similar histological and physiological properties to human skin and has been suggested as a good model for human skin permeability. In this series of experiments, the in\u2010vitro permeability of pig ear skin was compared with human (abdominal) skin and rat (dorsal) skin using both hydrophilic (water, mannitol, paraquat) and lipophilic (aldrin, carbaryl, fluazifop\u2010butyl) penetrants. Pig skin was found to have a closer permeability character than rat skin to human skin, particularly for lipophilic penetrants. Electrical conductivity measurements across pig skin membranes showed that skin conductivity could be a useful method for assessing the integrity of membranes, particularly when used in conjunction with water permeability assessments.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":45125982,"openaccessinfo":{"externalids":{"MAG":"1969832444","ACL":null,"DOI":"10.1111\/j.2042-7158.1992.tb05485.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the present study, the development and optimization of a thin film solid phase microextraction method (TF-SPME) was conducted for metabolomics profiling of eight steroid compounds (androsterone, dihydrotestosterone, dihydroepiandrosterone, estradiol, hydroxyprogesterone, pregnenolone, progesterone and testosterone) from urine samples. For optimization of extraction method, two extraction sorbents (PAN-C18 and PS-DVB) were used as they are known to be effective for isolation of low-polarity analytes. The stages of sample extraction and analyte desorption were considered as the most crucial steps in the process. Regarding the selection of the most suitable desorption solution, six different mixtures were analyzed. As a result, the mixture of ACN: MeOH (1:1, v\/v) was chosen in terms of the highest analytes' abundances that were achieved using the chosen solvent. Besides other factors were examined such as the volume of desorption solvent and the time of both extraction and desorption processes. The analytical determination was carried out using the ultra-high performance liquid chromatography coupled with high resolution tandem mass spectrometry detection in electrospray ionization and positive polarity in a scan mode (UHPLC-ESI-QTOF\/MS). The developed and optimized TF-SPME method was validated in terms of such parameters as extraction efficiency, recovery as well as matrix effect. As a result, the extraction efficiency and recovery were in a range from 79.3% to 99.2% and from 88.8% to 111.8%, respectively. Matrix effect, calculated as coefficient of variation was less than 15% and was in a range from 1.4% to 11.1%. The values of both validation parameters (recovery and matrix effect) were acceptable in terms of EMA criteria. The proposed TF-SPME method was used successfully for isolation of steroids hormones from pooled urine samples before and after enzymatic hydrolysis of analytes.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":257381911,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fmolb.2023.1074263","PubMedCentral":"10025495","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2023.1074263\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The MKD5 nickel deposit at Mount Keith is hosted within the Mount Keith Ultramafic Complex, a thick komatiitic dunite body previously interpreted as either a large volume lava flow or as a dikelike intrusion. The upper contact relationships of the dunite body are critical for the evaluation of an extrusive versus intrusive origin. New drill core examined during this study has revealed preserved upper contact relationships between the Mount Keith Ultramafic Complex and the enclosing dacitic volcanic rocks. These contacts have lobate geometries with apophyses of the ultramafic material intruding the overlying dacite and dacitic xenoliths within the ultramafic rock along all observed margins. These contact features indicate an intrusive relationship between the Mount Keith Ultramafic Complex and the enclosing stratigraphy, which is consistent with the lack of definitive extrusive features. Our new interpretation of the Mount Keith Ultramafic Complex suggests that thick komatiitic dunite bodies may be regarded as subvolcanic sills emplaced within and below an extrusive komatiite pile. Importantly this model implies that komatiitic dunite bodies are not an integral or even necessary feature of a komatiite flow field.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":129741294,"openaccessinfo":{"externalids":{"MAG":"2121658943","ACL":null,"DOI":"10.2113\/100.1.0149","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We estimate the relation between stock option (ESO) grants to the top five executives and future earnings to examine whether incentive alignment or rent extraction by top managers explains option granting behavior. The future operating income associated with a dollar of Black-Scholes value of an ESO grant is $3.71. To understand the source of these positive payoffs, we parse out ESO grant values into components predicted by economic determinants of option grants, governance quality, and a residual grant value. The payoffs to ESOs appear to be driven predominantly by the economic determinants of option grants and not poor governance quality.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54507092,"openaccessinfo":{"externalids":{"MAG":"2099456981","ACL":null,"DOI":"10.2139\/ssrn.318101","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study observed the complaint strategies occurred in complaint letters which were published in newspapers. It was analyzed based on Trosborg by using descriptive qualitative approach. It focused on the strategies of complaint and the most strategies of complaint. The data were taken from twenty complaint letters which were published in \"Your Letters\", a column for the readers to express their thoughts in Jakarta Post, especially those concerned with the service. In the newspaper, people write their complaint directly. Based on the theory, there are eight complaint strategies but the findings show that there are seven complaint strategies which occurred in the complaint letters, namely, Annoyance, Ill consequences, Indirect, Direct, Modified blame, Explicit condemnation of the accused?s action and Explicit condemnation of the accused as a person. The findings also show that complainers did not use one strategy, namely hint strategy. To conclude, the occurrences of complaint strategies show that most of the complainers use explicit condemnation of the accused?s action strategy as the strategy of complaint. The complainer states directly to the complainee by complaining about the complainee?s behavior.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":68194588,"openaccessinfo":{"externalids":{"MAG":"51147162","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One hundred and twenty-nine cases of atrial flutter were analyzed to assess the A-V conduction. The R-R intervals, the A-V conduction ratio, and the F-R intervals were measured in each case. Conduction in atrial flutter was defined either as constant or as variable depending on whether the A-V conduction ratio was fixed or variable. Furthermore, atrial flutter was defined as regular whenever the R-R intervals were mathematically related to each other, any interval being a multiple of the F-F cycle. On the other hand, atrial flutter was defined as irregular when the R-R cycles did not reflect a precise mathematical relationship. The R-R intervals in irregular atrial flutter were not exactly multiples of the F-F cycle. This was because the F-R intervals were variable. Sixty-five cases of atrial flutter had constant A-V conduction, whereas 64 cases were associated with variable A-V conduction. Eighty-eight per cent of cases with constant conduction were regular. On the contrary, 91% of cases with variable A-V conduction were irregular. These data reflect a relationship between the constancy of the A-V conduction ratio and the regularity of the R-R intervals. Several mechanisms were identified as being responsible for atrial flutter irregularity. Alternation of the F-R intervals was the most frequent mechanism leading to irregularity of atrial flutter with constant A-V conduction. Alternating Wenckebach periodicity was the most common cause of irregularity in atrial flutter with variable conduction ratio. Concealed conduction of blocked impulses was also frequently involved in determining atrial flutter irregularity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27659211,"openaccessinfo":{"externalids":{"MAG":"182143969","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We perform the in situ characterization, by second-order optical autocorrelation, of femtosecond pulses transmitted by near-field optical probes. We demonstrate that transmission through hollow pyramid probes with diameter down to 65 nm has negligible effects on the duration of pulses as short as 30 fs. We also show that such probes allow obtaining, at their output, sufficient peak power to perform nonlinear optical experiments in the near field on such a space and time scale.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":120919829,"openaccessinfo":{"externalids":{"MAG":"1993522105","ACL":null,"DOI":"10.1063\/1.1852088","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In the traditional standard of internal friction measurement the torsion pendulum and vibration reed were preferentially recommended where the issue of strain amplitude dependence of internal friction was not concerned. To more precisely measure the internal friction and modulus at various strain amplitude, in this paper the strain amplitude dependence of internal friction and modulus is considered by analyzing the stress distribution in the sample in different internal friction measurement methods. The formulas for the measurement of internal friction and modulus versus strain-amplitude are obtained by re-deriving the principal equations for internal friction and modulus measurements by torsion pendulum and vibration reed methods from the basic definition of internal friction. This provides a new standard for precise measurement of internal friction at different strain-amplitude in the cases of high strain-amplitude excitation or high damping materials where amplitude dependent effects always appear.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":139831381,"openaccessinfo":{"externalids":{"MAG":"2805188526","ACL":null,"DOI":"10.1590\/1980-5373-MR-2017-0850","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper focuses on the performance of tactical BVA quartz resonators, specifically their measured frequency stability. Data are presented demonstrating the resonators' ability to survive harsh environmental conditions. Test results suggest an oscillator using a tactical BVA resonator could be developed that would have very high frequency stability, be relatively small, and have low mass. The tactical resonators evaluated are 10-MHz, 3rd overtone, SC (stresscompensated) cut devices housed in HC-40 enclosures. The Q of the resonators tested was between 1.2 and 1.3 million.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110296899,"openaccessinfo":{"externalids":{"MAG":"2188859967","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Statement of purpose Data available on unintentional injuries at state and county levels are insufficient for effectively planning prevention efforts at a neighbourhood level. Concentrating interventions in neighbourhoods at greatest risk helps improve the programmatic and financial efficiency of limited prevention resources, and enables practitioners to more effectively demonstrate outcomes measures. Methods\/Approach We queried paediatric t2rauma registry data (N=5,380), over a 4 year period from two Level I Trauma Centres, and also statewide Emergency Department visit data for paediatric injuries (N = @111,000) for all Colorado hospitals in 2013. Data was analysed by age, mechanism of injury, zip code of residence, payer source and more, to produce geographic maps that allow local I. P. practitioners and partner agencies a visual representation of where a disproportionate volume of injuries are occurring. Integrating U.S. Census data on population demographics (i.e., race\/ethnicity, household income, etc.) provides additional contextual information that allows for refinement of program efforts. Results We have identified Colorado zip codes of mechanism-specific high risk (i.e., injury \"hot spots\") that will be used to build neighbourhood capacity to address primary prevention efforts. Adjusting for confounding factors, zip codes with fewer educated individuals and higher populations had higher hospital charges. Conclusions Injury burdens can vary greatly among communities in the same geopolitical area, and result in higher costs for treating paediatric trauma. Significance and contribution to the field Children's Hospital Colorado has initiated steps to implement The Prevention Institute's recommendation to \"\u2026 share healthcare data to map patterns of \u2026 injury and create community improvements,\" found in their document A Checklist of Strategies for Health Care-Community Prevention Integration. This approach also aligns with the six levels on the Spectrum of Prevention. This type of analysis can be used to focus prevention efforts in the areas of greatest need, and can also inform resource allocation for publicly and privately funded prevention efforts, support for injury-related public policy initiatives, and more.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":71775048,"openaccessinfo":{"externalids":{"MAG":"2016283176","ACL":null,"DOI":"10.1136\/INJURYPREV-2015-041602.17","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"When the human-robot interactions become ubiquitous, the environment surrounding these interactions will have significant impact on the safety and comfort of the human and the effectiveness and efficiency of the robot. Although most robots are designed to work in the spaces created for humans, many environments, such as living rooms and offices, can be and should be redesigned to enhance and improve human-robot collaboration and interactions. This letter uses autonomous wheelchair as an example and investigates the computational design in the human-robot coexistence spaces. Given the room size and the objects $O$<\/tex-math><\/inline-formula> in the room, the proposed framework computes the optimal layouts of $O$<\/tex-math><\/inline-formula> that satisfy both human preferences and navigation constraints of the wheelchair. The key enabling technique is a motion planner that can efficiently evaluate hundreds of similar motion planning problems. Our implementation shows that the proposed framework can produce a design around three to five minutes on average comparing to 10 to 20 minutes without the proposed motion planner. Our results also show that the proposed method produces reasonable designs even for tight spaces and for users with different preferences.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226965300,"openaccessinfo":{"externalids":{"MAG":"3106299469","ACL":null,"DOI":"10.1109\/LRA.2021.3097061","PubMedCentral":null,"ArXiv":"2011.07374"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Numerical simulations have predicted that an extended current sheet may be unstable to secondary magnetic islands in the vicinity of the X line, and these islands can dramatically influence the reconnection rate. In this Letter, we present the first evidence of such a secondary island near the center of an ion diffusion region, which is consistent with the action of the secondary island instability occurring in the vicinity of the X line. The island is squashed in the z direction with a strong core magnetic field. Energetic electrons with anisotropic or field-aligned bidirectional fluxes are found in the ion diffusion region, and the enhancement of energetic electron fluxes is more obvious inside the secondary island.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30416493,"openaccessinfo":{"externalids":{"MAG":"2071540177","ACL":null,"DOI":"10.1103\/PHYSREVLETT.104.175003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Randomized algorithms are analyzed as if unlimited amounts of perfect randomness were available, while pseudorandom number generation is usually studied from the perspective of cryptographic security or for the statistical properties of the numbers generated. Bach proposed studying the interaction between pseudorandom number generators and randomized algorithms. This paper follows Bach's lead; the authors assume that a (small) random seed is available to start up a simple pseudorandom number generator that is then used for the randomized algorithm. Randomized algorithms are studied for (1) sorting, (2) selection. and (3) obhvious routing in networks.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1}},"corpusid":17956460,"openaccessinfo":{"externalids":{"MAG":"1970309382","ACL":null,"DOI":"10.1145\/174130.174132","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1145\/174130.174132","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Affiliation with Alcoholics Anonymous parallels religious conversion, according to David R. Rudy in this timely study of the most famous self-help organization in the world.Drinkers who commit themselves to Alcoholics Anonymous embrace the radically different life-style, the altered world of the convert.To understand this conversion and, more important, to get a grip on the even deeper mystery of alcoholism itself, Rudy sought to answer these three questions: What processes are involved in becoming alcoholic? How does the alcoholic affiliate with, and become committed to, A. A. s belief system? What is the relationship between the world of A. A. members and that constructed by alcohologists?Rudy establishes the history and structure of A. A. and examines the organization s relationship to dominant sociological models, theories, and definitions of alcoholism.\"","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":145072965,"openaccessinfo":{"externalids":{"MAG":"2076669194","ACL":null,"DOI":"10.2307\/2579040","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Finding the best state assignment for implementing a synchronous sequential circuit is important for reducing silicon area or chip count in many digital designs. This State Assignment Problem (SAP) belongs to a broader class of combinatorial optimization problems than the well studied traveling salesman problem, which can be formulated as a special case of SAP. The search for a good solution is considerably more involved for the SAP than it is for the traveling salesman problem due to a much larger number of equivalent solutions, and no eeective heuristic has been found so far to cater to all types of circuits. In this paper, a matrix representation is used as the genotype for a Genetic Algorithm (GA) approach to this problem. A novel selection mechanism is introduced, and suitable genetic operators for crossover and mutation, are constructed. The properties of each of these elements of the GA are discussed and an analysis of parameters that innuence the algorithm is given. A canonical form for a solution is deened to signiicantly reduce the search space and number of local minima. Simulation results for scalable examples show that the GA approach yields results that are comparable to those obtained using competing heuristics. Although a GA does not seems to be the tool of choice for use in a sequential Von-Neumann machine, the results obtained are good enough to encourage further research on distributed processing GA machines that can exploit its intrinsic parallelism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":18271541,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Recently, Use of Auxiliary power unit(APU) is increasing by growing demand for improvement of insufficient electric power and installation of emergency generation devices in military tracked vehicles and civil markets. And the trend is that the units are demanded for smaller size, lighter weight and higher output power, etc to suit consumer demands. To achieve these, it is essential to develop high performance system. Therefore, in this study, it was conducted in numerical analysis to investigate flow characteristics of rotor in APU generator. Also output performance of APU applied on the rotor is analyzed by experimental method. As the result, higher rotating speed of rotor caused high air flow rate at suction and it leads to linear increase of discharging flow rate. The maximum theoretical power was achieved at 12 \/min of flow rate and, at that time, output power of generator was about 7.825 kW. Also, it can be confirmed the stabilization of output performance is achieved in about 2 seconds by experiment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":107572543,"openaccessinfo":{"externalids":{"MAG":"287339623","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Several case studies are examined in an attempt to relate Visible infrared spin scan radiometers Atmospheric Sounder (VAS) water vapor channel radiance data to atmospheric moisture. Since the 6.7 micrometer channel detects radiation emitted by atmospheric water vapor from a rather thick layer, a scheme is developed which weighted rawinsonde observations of relative humidity in a similar manner. A comparison of the two fields (weighted relative humidity values from gridded rawinsonde observations and the VAS water vapor image) indicates that even when mesoscale data are used, the technique only presented a smooth representation of the radiance field. This weighting function is dependent on both the temperature and moisture distribution of the atmosphere. Cross sections of relative humidity from the mesoscale rawinsondes are produced which sliced the water vapor imagery in particularly interesting regions (areas of high and low blackbody temperatures). Comparisons are then made between the cross sections and the variations in the VAS radiance data along the cross section line. Bright regions in the water vapor imagery (cold blackbody temperatures) are often associated with thin layers of high relative humidity or thick layers of only moderately moist air. The reverse also applies, i.e., dark regions (warm blackbody temperatures) in the imagery corresponded well with very dry regions in the cross sections.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":127796128,"openaccessinfo":{"externalids":{"MAG":"293766529","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"To understand the information flow in neural circuits, it is essential to \ndetermine how neurons translate synaptic input into spike output. In the \ncerebellum, Golgi cells are the only interneurons that inhibit granule cells in \nthe input layer, where mossy fibre (MF) signals converge onto both cell \ntypes. Golgi cells also receive inputs from parallel fibres (PFs, granule cell \naxons) that form synaptic contacts with the molecular layer interneurons and \nPurkinje cells. This synaptic organisation suggests the Golgi cells may be an \nimportant regulatory element in the cerebellar circuit. In this thesis, I used \ntargeted patch-clamp recordings guided by 2-photon microscopy to \nexamine the synaptic input and spike output patterns of Golgi cells in \nanaesthetised transgenic mice. I found that Golgi cells received bursty and \noccasionally rhythmic excitatory inputs and sparse inhibitory inputs in vivo. \nMy results also revealed that Golgi cells exhibit low spontaneous firing rates, \nand their spiking activity can display 1 Hz rhythmicity and synchrony with \nmillisecond precision. Remarkably, Golgi cells usually generated only a \nsingle spike time-locked to the stimulus by integrating multiple synaptic \ninputs during sensory stimulation. These results suggest that Golgi cells \nencode temporal information in their spikes, and will therefore transfer this \nmessage throughout the cerebellar network by controlling granule cell (PF) \nactivity. \nPurkinje cells, the sole output neurons of the cerebellar cortex, often \ndisplay large, single \"all-or-none\" synaptic responses from the strong \nexcitation by climbing-fibre (CF) inputs in vitro. However, the transmission at \nthe CF-Purkinje cell synapse in the intact brain remains poorly understood. \nUsing whole-cell voltage clamp recordings from Purkinje cells in \nanaesthetised rats, I revealed that the spontaneous CF excitatory \npostsynaptic currents (CF-EPSCs) can be bursty, indicating that high-frequency \nolivary axonal signals are transmitted to the cerebellum in vivo.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":81593425,"openaccessinfo":{"externalids":{"MAG":"10495651","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Consciousness has always been much concerned in cognition science and, with the discovery of implicit learning in artificial grammar learning (AGL) researches, influences of unconscious processes on human cognition have been unprecedentedly highlighted. Dozens of empirical investigations have distinguished two different types of learning, i.e. explicit learning and implicit learning which involve conscious and unconscious processing respectively. Hence their critical attributes and interactive patterns have undergone tentative explorations and several theoretical frameworks have been proposed to demonstrate the underlying mental mechanisms, most of which take the side of dualistic logic. Empirical data tend to indicate that, rather than stand in dichotomy, so often they co-exist only with a quantitative difference. The academic dilemma is now broken through by the graded consciousness hypothesis, as a result of which new perspective arises from the graded consciousness dimension to deeply investigate implicit learning. In the present research the dynamic mental evolution pattern has been explored in artificial grammar learning, concerning both consciousness and knowledge representation. The current research adopts hypothesis of distributive representation and representation rehearsal which indicates that the ever-optimizing distributive representation dominates the learning process. Thus graded consciousness comes into form due to the increasing contribution of conscious processing. A dual-task design was introduced in current study with reference to the PDP paradigm formerly adopted in implicit memory researches. The innovative paradigm adopted a 'slow' learning task and a 'quick' task and the contribution patterns of consciousness and unconsciousness are different in the two tasks, as a result of which the contributions of conscious and unconscious processes could be extracted dynamically along the learning course. This innovative paradigm also makes possible a direct investigation of was found with unconscious processing. In the beginning unconscious contribution prevailed but was eventually exceeded by conscious process in the subsequent blocks. However, in the first half of learning phase, consciousness contribution suffered an undulating performance while unconsciousness more stable. While entering the second half of learning phase, unconsciousness contribution exhibited a stagnating pattern and the uneven mode faded with consciousness process. These findings, compatible with those empirical researches assuming dichotomy logic, not only define distinguishable features for implicit learning and explicit learning, but also demonstrate the graded consciousness in artificial grammar learning and make possible a learning continuum progressing throughout the learning phase of artificial grammar. In the current study which assumed graded consciousness perspective the structures of knowledge representations have also been discussed indirectly. Conclusions are that the developing of unconscious representations precedes that of conscious representations, considering the undulation in the first half phase for consciousness and the stagnation in the second half phase for unconsciousness, which indicates a possible synergic effect between conscious and unconscious processing.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":151391047,"openaccessinfo":{"externalids":{"MAG":"2565889345","ACL":null,"DOI":"10.3724\/SP.J.1041.2014.01649","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background\/Aims. It remains unclear whether tenofovir disoproxil fumarate- (TDF-) based combination therapy produces better outcomes than TDF monotherapy in chronic hepatitis B (CHB) patients. The aim of this study was to compare the efficacy of the two regimens by performing a meta-analysis. Methods. A comprehensive literature search was performed on the comparison of TDF-based combination therapy and monotherapy for CHB patients in the PubMed, Embase, Web of Science, and the Cochrane Libraries. Both dichotomous and continuous variables were extracted and pooled outcomes were expressed as risk ratio (RR) or standard mean difference (SMD). Results. Nine eligible studies (1089 subjects in total) were included in our analysis. The proportion of patients with undetectable HBV DNA at 24, 48, and 96 weeks were similar between the two comparable groups (62.5% versus 70.9%, P = 0.086; 78.1% versus 83.7%, P = 0.118; 86.4% versus 87.9%, P = 0.626, resp.). HBV DNA reduction, rates of ALT normalization, hepatitis B e antigen (HBeAg) loss, and HBeAg seroconversion were also similar between the two groups. Conclusions. On the current data, TDF-based combination therapy seemed to be no better than those achieved by monotherapy. Further studies are needed to verify this comparison.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5781288,"openaccessinfo":{"externalids":{"MAG":"2227200179","ACL":null,"DOI":"10.1155\/2016\/7214020","PubMedCentral":"4737451","ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1155\/2016\/7214020","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In nuclear medicine, the development of portable imaging devices that provide high imaging resolution and sensitivity, capable of imaging gamma rays with a wide energy range and multiple radioisotopes tracing capabilities, is so important. These goals have been possible thanks to developing a compact Compton camera, a collimatorless detector coupled to compact silicon photomultiplier(SiPM) array, using scintillator crystal. In this study, the portable segmented GAGG:Ce scintillator-based Compton camera (CC) is optimized with the GATE, a Monte Carlo simulation toolkit based on Geant4, to maximize its performance for a wide range of gamma-ray energy (364\u20131000 keV). The geometrical parameters are selected as optimization parameters to investigate their effects on CC's performance, including imaging resolution and absolute detection efficiency (DE a ). The geometry parameters of CC include the planner area of scatterer and absorber detectors, their thicknesses, and the distance between them. The results for the energy range of 364\u20131000 keV show that the most important contributions to the spatial resolution and DE a of the camera are SAD (scatterer to absorber distance) and the scatterer area while changing absorber area (AA ) showed the most negligible impact. In the short SADs, imaging resolution and DE a are significantly affected by the detector's size and thickness. On the other hand, in the long SADs (> 4 cm), both spatial resolution and DE a are significantly affected by the detector's area but less affected by the detector's thickness. Decreasing the scatterer's thickness and the absorber's size or thickness improves imaging resolution without significantly reducing DE a . The simulation study's findings presented here will provide valuable guidelines for researchers choosing a desired CC's design according to particular objectives, manufacturing limitations in scintillator growth, cost, etc.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":256325324,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1748-0221\/18\/01\/P01035","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Manitoba Act provided for substantial grants of land to the Metis inhabitants\nof the new province. Until recently, most historians viewed the intentions of the\nfederal government in relation to these land grants in a favourable Light, blaming\noverwhelming numbers of Ontario immigrants and the character of the Metis\nthemselves for the rapid transfer of the lands out of Metis hands. This consensus\ncame under attack during the 1970s and 1980s, as new research shifted the blame\nto the government's administration of the land grants. This study of the land grants\nreceived and lots sold by a sample of Metis families in Manitoba challenges both\nearlier arguments. The authors conclude that the Metis had little difficulty receiving\ntitle to the lands promised them in the Manitoba Act, that they behaved rationally\nin the land market of the 1870s and 1880s, and that they received, on the whole,\nsubstantial monetary benefits when they sold their lands.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":55144961,"openaccessinfo":{"externalids":{"MAG":"1507754875","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Copoly(2-nonyl-2-oxazoline)-stat-poly(2-dec-9'enyl-2-oxazoline)s can be crosslinked by the thiol-ene reaction with glycol dimercaptoacetate. The copoly(2-oxazoline)-stat-copolyester is tested as dielectric for high-voltage applications, either as unfilled resin or as composite with nanoscaled fillers of silica, alumina, and hexagonal boron nitride. During AC voltage tests, all materials have an average breakdown strength of 45-50 kV mm-1 . For DC voltage tests, samples with SiO2 (hBN) have an average breakdown strength of \u2248100 (80) kV mm-1 , while the unfilled copoly(2-oxazoline) has an average breakdown strength of \u224860 kV mm-1 . Permittivity measurements at 20 \u00b0C and 50 Hz reveal that all nanocomposites are dielectrics (D = 0.06-0.08), while the unfilled copoly(2-oxazoline)s has a high loss factor of D = 8.43. This phenomenon can be retraced to the phase separation in the crosslinked copolymer, the M-OH functionality of silica and alumina particles, and models of polymer-particle interactions such as the Tanaka model, revealing that the nanofillers reduce the interfacial and dipolar polarizability.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4329586,"openaccessinfo":{"externalids":{"MAG":"2782486702","ACL":null,"DOI":"10.1002\/marc.201700681","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The effect of types and amount of powder materials, admixtures, sand and water \ncontent on the properties of self-compacting concrete (SCC) have been investigated \nby tests on the mortar fraction. Tests on concrete have also been a carried out to \nconfirm the most important effects. \nThe component materials used were \n* eight types of powder- PC and SRC, GGBS, PFA, CSF and three types of LSP, \n* six superplasticizers -a naphthelene (Conplast 430) and melamine type, two copolymers, \none polycarboxylic ether (Glenium 51) and one formulated for S CC, \n* two viscosity agents - Welan gum and a cellulose product , \n* one fine and coarse aggregate, generally at volumetric proportions of 40-47.5% of \nthe mortar and 31.7% of the concrete respectively. \nTesting has concentrated on workability and workability retention of mixes with a \nsingle powder, binary and ternary powder combinations, with and without a viscosity \nagent. Tests have included spread\/slump flow, V-funnel flow time, and two-point \nworkability tests for mortar and concrete, a U-box test for concrete, and some \nstrength tests on concrete. \nThe most important outcomes include: \n* Glenium 51, the most efficient superplasticizer, was selected for most of the \nprogramme, added at 1 minute after the start of mixing. \n* Excellent workability and workability retention was obtained in binary and \nternary mixes containing CSF, and in SRC single powder mixes. \n* Yield stress and plastic viscosity are two distinct and independent properties. \n* Welan gum has better compatibility with Conplast 430 than Glenium 5l; its use \nimproved workability retention but slightly decreased strength. \n* There are strong relations between the properties of concrete and its mortar component, and the rheological constants and single point test results for mortar and concrete. \n* The rheology of some mortar mixes may be better described by the Herschel- \nBulkley model than by the Bingham model.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":135046110,"openaccessinfo":{"externalids":{"MAG":"21726246","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The crisis in rural America is far from over - changing demographics, economic decline and increasing poverty continue to plague rural areas. This book focuses on policy-relevant research that addresses the vital issues of employment, demographics, environment and technology. It offers a broad perspective on the problems and presents proposals for revitalizing rural America.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":152507694,"openaccessinfo":{"externalids":{"MAG":"334577091","ACL":null,"DOI":"10.5860\/choice.29-6593","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"An inducible program of inflammatory gene expression is a hallmark of antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. Here we have identified a highly conserved Zinc finger DNA binding protein CNBP (also called ZNF9) upregulated in myeloid cells exposed to lipopolysaccharide. CNBP resides primarily in the cytosol and upon TLR4 engagement, CNBP translocate to the nucleus. To investigate the functional consequences of these events, we generated mice lacking CNBP and characterized the role of CNBP in controlling the inducible transcriptional program using a combination of RNA-sequencing and multiplex gene expression analysis (Nanostring). In response to an array of signals such as LPS, CNBP-deficient macrophages were impaired in their ability to induce important immune genes including IL12p40 and IL6 amongst others. CNBP-deficient cells showed normal activation of TBK1 and p65. However, the nuclear translocation of c-Rel that is critical for the inducible expression of IL-12p40 was significantly compromised in cells lacking CNBP. Furthermore, Chromatin Immunoprecipitation experiments revealed that CNBP itself bound the IL12 promoter and c-Rel binding to this promoter was compromised in CNBP-deficient macrophages. Lastly, ectopic expression of wild type CNBP but not a mutant form that could not be phosphorylated together with c-Rel led to synergistic activation of an IL12 promoter driven reporter gene. Collectively, these findings identify CNBP as a novel DNA binding protein that acts as a transcriptional regulator controlling the inflammatory program in macrophages.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":255722431,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.198.supp.70.11","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An important controversy in public finance is whether long-run capital taxes are optimally zero or not, with a broad variety of models supporting each case. This paper examines the question whether capital is special and if so, what the underlying principle could be that explains both types of results. I find that capital is provided without distortions in a wide class of models, i.e. that its marginal product is the same in first and second best. The conditions for this to hold are that the government is able to tax all of capital's co-factors of production separately and that capital does not enter the utility function. When individually rational behavior leads to sub-optimal capital accumulation, then capital taxes are used to implement the optimal allocation. The intuition is that capital is an intermediate good; optimal taxation seeks to tax endowments and intermediate goods do not have any endowment component.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3330056,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Retinoic acid, an active metabolite of retinol, is known to regulate cell proliferation, differentiation, and morphogenesis during normal development of many tissues. Using chick embryonic tarsometatarsal skin, we showed previously that the expression of Gbx1, a divergent homeobox gene, is increased in the epidermis through interaction with retinol\u2010pretreated dermal fibroblasts followed by epidermal transdifferentiation to mucous epithelium. This present study was performed to elucidate the effects of retinoic acid and Gbx1 on feather\u2010bud formation and epidermal transdifferentiation. Results: We showed that Gbx1 was expressed in the chick embryonic dorsal epidermis as early as at placode stage (Hamburger and Hamilton stage 31) and increased in amount during feather\u2010bud formation. Treatment with 1 \u03bcM retinoic acid for 24 hr inhibited feather\u2010bud formation and induced the transdifferentiation of the epidermis to a mucosal epithelium with a concomitant increase in Gbx1 mRNA expression in the epithelium. Furthermore, transient transfection of the epidermis with Gbx1 cDNA by electroporation induced elongation of the feather bud, but did not result in transdifferentiation. Conclusions: These results indicate that Gbx1 was involved in the feather\u2010bud formation and was one of target genes of retinoic acid and that other signals in addition to Gbx1 were required for epidermal mucous transdifferentiation. Developmental Dynamics 241:1405\u20131412, 2012. \u00a9 2012 Wiley Periodicals, Inc.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":5316070,"openaccessinfo":{"externalids":{"MAG":"1981432191","ACL":null,"DOI":"10.1002\/dvdy.23834","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/dvdy.23834","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Smart cities provide citizens with smart and advanced services to improve their quality of life. However, it has been observed that the collection, storage, processing, and analysis of heterogeneous data that are usually borne by citizens will bear certain difficulties. The development of the Internet of Things, cloud computing, social media, and other Industry 4.0 influencers pushed technology into a smart society's framework, bringing potential vulnerabilities to sensor data, services, and smart city applications. These vulnerabilities lead to data security problems. We propose a decentralized data management system for smart and secure transportation that uses blockchain and the Internet of Things in a sustainable smart city environment to solve the data vulnerability problem. A smart transportation mobility system demands creating an interconnected transit system to ensure flexibility and efficiency. This article introduces prior knowledge and then provides a Hyperledger Fabric-based data architecture that supports a secure, trusted, smart transportation system. The simulation results show the balance between the blockchain mining time and the number of blocks created. We also use the average transaction delay evaluation model to evaluate the model and to test the proposed system's performance. The system will address residents' and authorities' security challenges of the transportation system in smart, sustainable cities and lead to better governance.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":234366348,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2021\/5597679","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/scn\/2021\/5597679.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nEvaluation of low back pain (LBP) requires a condition specific disability questionnaire along with pain and satisfaction measure such as self-assessment pain scales. Dallas Pain Questionnaire (DPQ) is a 16-item visual analog scale, developed for evaluating patient's cognitions about the percentage that chronic pain affects four aspects of the subject's lives. It's easy to understand; can be answered in 3-5 min and can be scored in <1 min. This reliability and validation study offers health-care providers an opportunity to utilize this distinct questionnaire in Turkish population with back pain. The objectives are translation of Dallas questionnaire from English to Turkish language and to perform validation and reliability study.\n\n\nMETHODS\nA total of 102 patients (79 women and 23 men) with mean age of 50.2 years and LBP for at least 3 months answered DPQ along with five other previously translated and validated questionnaires in Turkish language. Fifty-nine of these patients participated retest reliability after 7 days. Internal consistency and test-retest analyzes were conducted to determine the reliability and convergent validity was evaluated for the validation study.\n\n\nRESULTS\nThe questionnaire was noted to have high internal consistency. The test-retest analysis revealed an excellent correlation (ICC=0.969). Pearson correlation coefficient shows that all subscales (sections) of DPQ are significant and comparable with each of the other questionnaires included in this study proving that it has sufficient convergent validity (p<0.001).\n\n\nCONCLUSION\nThe Turkish version of DPQ is content, valid, and reliable. DPQ is sensitive to use in patients with LBP.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":234262530,"openaccessinfo":{"externalids":{"MAG":"3135802644","ACL":null,"DOI":"10.14744\/AGRI.2021.24861","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A preparative method for isolating pure viral envelopes from a type-C RNA tumor virus, Rauscher murine leukemia virus, is described. Fractionation of virions of Rauscher murine leukemia virus was studied after disruption of the virions with the detergents sodium dodecyl sulfate of Nonidet P-40 in combination with ether. Fractionation was performed through flotation in a discontinuous sucrose gradient and, as appeared from electron microscopic examination, a pure viral envelope fraction was obtained in this way. By use of sensitive competition radioimmunoassays or sodium dodecyl sulfate-polyacrylamide gel electrophoresis after immunoprecipitation with polyvalent and monospecific antisera directed against Rauscher murine leukemia virus proteins, the amount of the gag and env gene-encoded structural polypeptides in the virions and the isolated envelope fraction was compared. The predominant viral structural polypeptides in the purified envelope fraction were the env gene-encoded polypeptides gp70, p15(E), and p12(E), whereas, except for p15, there was only a relatively small amount of the gag gene-encoded structural polypeptides in this fraction.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34839382,"openaccessinfo":{"externalids":{"MAG":"1858238988","ACL":null,"DOI":"10.1128\/jvi.27.3.595-603.1978","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1128\/jvi.27.3.595-603.1978","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The concept of scenic landscape protection represents a relatively new approach to conservation and economic development in developing countries. An interdisciplinary and interinstitutional team of professionals in landscape architecture, architecture and environmental law from the University of Florida, University of Costa Rica and the Universidad de Diseno examined the feasibility of a scenic corridor along the economically depressed but ecologically rich southern Pacific Coast of Costa Rica. The Costanera Sur is a 50 kilometer paved highway that offers stunning ocean and mountain views as well as access to Costa Rica's remote Osa peninsula, the largest remaining tropical wilderness on the Pacific Coast of Central America. The effort gained a sense of urgency due to increasing development pressure and the imminent rerouting of the Pan-American Highway, the major transportation corridor linking North and South America. In addition, access to the beaches for ordinary Costa Ricans has become an increasing concern as foreign investment in exclusive tourism and real estate infrastructure threatens to close off traditional swimming, surfing, picnic and camping areas. The primary goal of the study was to develop a replicable model for neotropical conservation and development that uses an existing road corridor as the organizing principle for the protection of ecological, cultural, recreational and scenic resources in a developing country where tourism represents the largest source of foreign exchange.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":129307485,"openaccessinfo":{"externalids":{"MAG":"2022765876","ACL":null,"DOI":"10.2495\/ST060261","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A thorough search of the sky exposed at the Pierre Auger Cosmic Ray Observatory reveals no statistically significant excess of events in any small solid angle that would be indicative of a flux of neutral particles from a discrete source. The search covers from \u221290\u00b0 to +15\u00b0 in declination using four different energy ranges above 1 EeV (1018 eV). The method used in this search is more sensitive to neutrons than to photons. The upper limit on a neutron flux is derived for a dense grid of directions for each of the four energy ranges. These results constrain scenarios for the production of ultrahigh energy cosmic rays in the Galaxy.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":122292048,"openaccessinfo":{"externalids":{"MAG":"2131917827","ACL":null,"DOI":"10.1088\/0004-637X\/760\/2\/148","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Salmonella is one of the frequent causes of bacterial foodborne diseases with major public health impact in industrialized countries. Food-producing animals, in particular poultry, are major sources of human salmonellosis. Salmonella is normally found in the gastrointestinal tract of animals and can contaminate the carcass during the slaughtering process. In poultry, crops are also colonized by this pathogen. Crops are more likely to get ruptured during evisceration and contaminate the carcass and therefore present a health risk to consumers. Reducing Salmonella colonization in crops could decrease carcass contamination and is considered a potential preharvest critical control point in poultry production. Furthermore, rapid and reliable diagnostic methods to detect Salmonella are needed to monitor crop colonization to help ensure food safety. However, detection of Salmonella by bacteriological methods is time consuming and labor intensive and is not suitable for routine screening of a large number of samples. Therefore, this study was undertaken to validate a real-time PCR (RPCR) assay for the detection of Salmonella spp. in crop samples of broiler chickens. In total, 997 crop samples (35 spiked, 962 field) were processed by both RPCR and culture. The RPCR correctly identified all spiked crop samples. Out of 962 field crop samples, 100 tested positive by RPCR and 88 tested positive by culture for Salmonella, giving a sample level prevalence of 10.4 % (95% CI: 8.54 to 12.50%) and 9.1% (95% CI: 7.40 to 11.15%), respectively. The agreement beyond chance between RPCR and culture was 92% (P < 0.001) and 100% (P < 0.001) for field and spiked samples, respectively. Compared with culture, the sensitivity and specificity of RPCR were 98.86 and 98.51% for field samples and 100 and 100% for spiked samples, respectively. Where bacterial speciation is required, only the positive samples would be cultured. Therefore, RPCR can be used as a good screening tool for Salmonella spp. in crops by eliminating the time-consuming and labor-intensive culture of negative samples.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25403096,"openaccessinfo":{"externalids":{"MAG":"1981539449","ACL":null,"DOI":"10.3382\/ps.2010-00634","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.3382\/ps.2010-00634","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Objectives: This study aims to identify the success rate and correlated factors of combined local and systemic methotrexate (MTX) injection treatment in cesarean scar pregnancy (CSP). Materials and Methods: The combined local and systemic MTX administration has been used for CSP weeks 8\u201314 at Tu Du Maternal Hospital; however, its effectiveness and correlated factors have not been closely investigated. This is a retrospective case series of 123 CSP patients between 8 and 14 weeks of gestation who were treated at Tu Du Hospital from the year 2016 to 2020. Results: The success rate, uterine-sparing rate, and side effects of MTX treatment are 50.4%, 95%, and 17.2%, respectively. The factors related to treatment failure with statistical significance included gestational age (odds ratio [OR] = 3.99), residual myometrial thickness >3 mm (OR = 0.37), and postprocedure gestational sac diameter (OR = 1.09). Conclusion: Combined local and systemic MTX injection is minimally invasive and effective in CSP weeks 8\u201314. Therefore, it should be utilized routinely.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260820582,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4103\/gmit.gmit_135_22","PubMedCentral":"10553595","ArXiv":null},"license":"CCBYNCSA","url":"https:\/\/doi.org\/10.4103\/gmit.gmit_135_22","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Goals To evaluate practices and barriers for the use of probiotics in acute diarrhea among pediatric gastroenterologists. Background Probiotics have shown significant therapeutic potential in acute infectious diarrhea. However, literature data regarding practice patterns in childhood are limited. Study A web-based 9-item survey among 1854 pediatric gastroenterologists worldwide. Results Only 634 (34%) responded. Forty-one were excluded owing to incomplete data. Finally 593, USA (n=407) and non-USA (n=186) participants, showed: limited use in acute diarrhea (28% and 32% prospectively), prescription of a 1 strain product only by 31% and 24%, respectively, and limited utilization in ambulatory settings (43% and 51%, respectively) and in prevention of diarrhea (2.6% and 3.4%, respectively). Most participants felt there is lack of useful clinical guidelines (91% and 84%, respectively), and found this therapy effective or very effective (54% and 62%, respectively). Dosing and duration were extremely variable, the youngest age treated ranged from 2 months to 2 years of age, and adverse effects were extremely rare. These characteristics were shared by USA and by non-USA participants, with no significant differences between groups (P>0.05). Conclusions Many pediatric gastroenterologists worldwide do not use probiotics for acute diarrhea owing to lack of appropriate guidelines and\/or poorly designed products. Therefore, worldwide health authorities should provide pharmaceutical and clinical guidelines for the appropriate use of probiotics in acute diarrhea of childhood.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":205778499,"openaccessinfo":{"externalids":{"MAG":"2322986605","ACL":null,"DOI":"10.1097\/MCG.0b013e3181ef375d","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes a new auditory-based distance measure intended for use in a concatenated synthesis technique wherein the time- and frequency-domain characteristics are used to perform natural-sounding speaker synthesis. Whereas most concatenation systems use large databases (often +100,000 units), we begin from a small, limited database (approx. 400 units) and use a new spectral distortion measure to aid in the selection of phones for optimal concatenation. At the transition between speech segments, the new auditory-based distance metric assesses perceived discontinuities in the frequency domain. The distortion measure, which employs the Carney (see J. Acoust. Soc. Am., vol.93, p.401-17, 1993) auditory model, is used to select phones which minimize the perceived distortion between concatenated segments. Moreover, time- and frequency-domain methods can shape the prosodic and spectral characteristics of each speech segment. The final results demonstrate improved performance over standard concatenation methods applied to small databases.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":17250354,"openaccessinfo":{"externalids":{"MAG":"2167206286","ACL":null,"DOI":"10.1109\/ICASSP.1997.598820","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We review the initial impressions of the first 65 patients evaluated neurologically at Madigan Army Medical Center as mandated by the Comprehensive Clinical Evaluation Program of the Department of Defense for Persian Gulf veterans. No consistent patterns of neurologic disease or new neurologic syndromes emerged. Our experience suggests that full neurological evaluation of such patients without a clear history of neurological symptoms is not cost effective. Headaches and sleep difficulties were the two most frequent complaints. We suggest that sleep disorders may be underdiagnosed in active duty populations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33883451,"openaccessinfo":{"externalids":{"MAG":"2407482418","ACL":null,"DOI":"10.1093\/MILMED\/160.10.505","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ability to perform fast, accurate, deformable registration with intraoperative images featuring surgical excisions was investigated for use in cone-beam CT (CBCT) guided head and neck surgery. Existing deformable registration methods generally fail to account for tissue excised between image acquisitions and typically simply \"move\" voxels within the images with no ability to account for tissue that is removed (or introduced) between scans. We have thus developed an approach in which an extra dimension is added during the registration process to act as a sink for voxels removed during the course of the procedure. A series of cadaveric images acquired using a prototype CBCT-capable C-arm were used to model tissue deformation and excision occurring during a surgical procedure, and the ability of deformable registration to correctly account for anatomical changes under these conditions was investigated. Using a previously developed version of the Demons deformable registration algorithm, we identify the difficulties that traditional registration algorithms encounter when faced with excised tissue and present a modified version of the algorithm better suited for use in intraoperative image-guided procedures. Studies were performed for different deformation and tissue excision tasks, and registration performance was quantified in terms of the ability to accurately account for tissue excision while avoiding spurious deformations arising around the excision.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3942516,"openaccessinfo":{"externalids":{"MAG":"1997260438","ACL":null,"DOI":"10.1117\/12.878258","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10448501","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Isolation of total RNA from frozen muscle and fat samples typically results in small yields due to the presence of connective tissue between muscle fibers, which impairs complete tissue homogenization, and the excess of fat and relatively small cellularity of adipose tissue. Meat quality studies involve determination of fatty acid composition and content from muscle and subcutaneous fat samples, a process that may produce an excess of lyophilized tissue samples. The purpose of this work was to investigate the stability of total RNA in lyophilized tissue samples generated during the routine detection of fatty acid content of pig muscle and fat tissues, stored at room temperature or at -20 degrees C. The protocol described here results in increased yields of total RNA from freeze-dried samples stored at -20 degrees C, which facilitates the homogenization step. The isolated RNA is suitable for common gene expression techniques such as final point and quantitative reverse transcription-PCR.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9506529,"openaccessinfo":{"externalids":{"MAG":"2157676273","ACL":null,"DOI":"10.2527\/jas.2009-2298","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The author in his present paper reports a program of comparative materials testing of which the purpose was to assess the value of positive pressure polymerization of thermosets. This particular program required polymerization temperature measurements. K-value determinations, and cone indentation hardness tests to be made on samples of plastic material polymerized under positive liquid or steam pressure and in cuvets, respectively, the conditions of polymerization being those which are used in actual practice. The results obtained indicated a favorable influence of positive liquid pressure polymerization on the final hardness of the plastic material.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":26605394,"openaccessinfo":{"externalids":{"MAG":"2414694952","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"An efficient algorithm is presented for estimating a covariance matrix consisting of a low-rank signal term and a full-rank noise term, known apart from a scalar factor. For each sample of the vector of sensor outputs, the algorithm approximates, in the least-squares sense, a rank-one update of the covariance matrix, under the side condition that the rank of the signal term remains bounded. If the model noise is spatially colored, the least-squares approximation is preceded by spatial prewhitening, It is shown that if the rank of the signal term is small compared to the number of sensors, then the proposed algorithm requires substantially less computational work than conventional averaging. Some simulation results are included, indicating that the proposed algorithm reduces the variance of some commonly used spectral estimators in off-target directions, without impairing their detection and resolution properties.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":34766496,"openaccessinfo":{"externalids":{"MAG":"2106479198","ACL":null,"DOI":"10.1109\/TASSP.1986.1164779","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Measuring supply chain performance is very necessary for a company, however, it is more important to identify the proper indicators based on which the performance can be evaluated. The paper benchmarks the performance measurement metrics which has been further validated by measuring the performance of garment companies in India. The analysis provides the importance of inventory turnover (ITR) and cash to cash cycle period (CCC) in supply chain performance measurement. The study also develops a relationship between CCC and ITR especially in the garment industry by considering the Indian context.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":16879456,"openaccessinfo":{"externalids":{"MAG":"2743373558","ACL":null,"DOI":"10.5121\/IJMVSC.2015.6206","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pharmacists in Malaysia practise their profession in rugged terrains which demand both professional skills and pioneering spirits. Many of the current pharmaceutical standards, practices, and legislations need overhauling in order to meet the aspiration of the nation in this new millennium. The Malaysian Pharmaceutical Society has a vital role to play. The profession requires the greatest understanding of the Malaysian Medical Association and the Government in this transition period.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":7648697,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A combined biodynamic and vehicle model is used to assess the vibration and performance of a human operator performing driving and other tasks. The other tasks include reaching, pointing and tracking by the driver and\/or passenger. This analysis requires the coordinated use of separate and mature software programs for anthropometries, vehicle dynamics, biodynamics, and systems analysis. The total package is called AVB-DYN, an acronym for Anthropometrics, Vehicle, and Bio-DYNamics. The objectives and architecture are discussed, and then a preliminary version of this package is demonstrated in an example where a HMMWV (High Mobility Multipurpose Wheeled Vehicle) operator is performing a driving task.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":110925205,"openaccessinfo":{"externalids":{"MAG":"2226271486","ACL":null,"DOI":"10.4271\/2004-01-2152","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The functonal approach,with its focuses on the function or functions of texts and translation,has played a mjor role in the development of translation studies.Despite its major contributions,the approach also involves some inherent limitations.This paper discusses the functionalist approach in depth.By analyzing the ideas of major functionalists,i.e.Reiss's text type and language function,Holz-Manttari's model of translation action,Vermeer's Skopos theory and Nord's explanation of functionalist approaches,the paper provides a critical review of this approach,aiming for a better understanding of this approach.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":142425104,"openaccessinfo":{"externalids":{"MAG":"918569232","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study examines the relationship between protest activity and political institutions. The fragmentation of the party system and whether parties operate in parliamentary or presidential systems are important in shaping the political opportunity structure for civil protests. An OLS regression analysis across 90 countries and a total of 402 electoral periods indicates that a larger number of political parties in the legislature tend to curtail civil protests in parliamentary systems. In contrast, in presidential systems with fragmented legislatures there is a higher tendency for protest.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":154516324,"openaccessinfo":{"externalids":{"MAG":"2075737900","ACL":null,"DOI":"10.1080\/00344893.2013.800348","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"To elucidate the nature of myospherulosis, the authors tried to produce this state in vitro by mixing vitamin E, oleic acid, linoleic acid, and lanolin with human blood components, such as whole blood, washed erythrocytes, plasma, and fixed erythrocytes, respectively. Myospherulosis was produced in all mixtures in these experiments. The authors concluded the following. A thin parent body wall of myospherulosis is formed initially as a result of the physical emulsion phenomenon between lipid-containing materials and blood. Erythrocytes then are enclosed in the parent body. The parent body membrane gradually is reinforced by the deposition of plasma proteins, which are insoluble in ethanol. Thereafter, the erythrocytes become endobodies by the deposition of their contents to the membrane of the parent body. The pores of the endobodies are formed in the process of erythrocyte degeneration. The contents of the erythrocytes, such as hemoglobin, would attach to the parent body. Thus myospherulosis would become complete. In humans, the characteristics of the parent body membranes differ from each other, depending on how much the hemoglobin or a part of the endobody membrane attaches to the parent body membrane.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":40771506,"openaccessinfo":{"externalids":{"MAG":"134954496","ACL":null,"DOI":"10.1093\/AJCP\/99.3.249","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \u03b1-Damascone is widely used in perfumes. However, the manufacture of \u03b1-damascone remains challenging owing to the limitations of current production processes. Herein, \u03b1-damascone was successfully synthesized from \u03b1-ionone using a new route involving only four steps, namely oximization, epoxidation, dehydration, and reduction. The total yield was 54.9% with a final chemical purity of 97% (by GC). Only water, cyclohexane, and ethanol were used in the reactions except in the purification step, and all solvents could be recycled. The structures of the intermediates and target compound were identified by 1H NMR and 13C NMR analyses and MS experiments. This route is a simple and successful method for the industrial preparation of \u03b1-damascone.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-22":2,"2024-26":1}},"corpusid":108587505,"openaccessinfo":{"externalids":{"MAG":"2922847863","ACL":null,"DOI":"10.2478\/pjct-2019-0009","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.2478\/pjct-2019-0009","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In her late thirteenth-century dialogue, the Mirror of Simple Souls, Marguerite Porete reframes the origin and the function of penitential practice by drawing on conceptions that associate Mary Magdalene with original sin and personal salvation. With the cult of the Magdalen flourishing in the Low Countries and across Europe, Porete adopted the saint to concretize her doctrine of the annihilated soul. This article argues that the saintly sinner's conversion is no longer defined through chastity, contrition, and the performance of works of goodness in the Mirror but, rather, through detachment, pure intention, and divine love. Furthermore, an analysis of \"the consideration of the Magdalen\" reveals that Porete's interpretation of the metaphor of tilling the earth presents a riposte to the exegetical tradition that considered Mary Magdalene a symbol of sin. As such, Porete recasts the contemplative and penitent Magdalen of popular culture into a model of the annihilated soul.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":169113086,"openaccessinfo":{"externalids":{"MAG":"259463829","ACL":null,"DOI":"10.5325\/JMEDIRELICULT.39.2.0149","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Given the rapid growth of older Americans and the increased incidence of divorce among this population, it is paramount to identify negative health outcomes following marital transition and investigate the potential protective role of social support. Our study aims to identify relationships between change in depression and marital transitions, test whether social support moderates this association, and to examine variation by gender. The sample included 3,705 participants from the Health and Retirement Study, who reported being married or partnered in 2012. Changes in marital status were measured between 2012 and 2014 (remained married\/partnered (reference), divorced\/separated, and widowed). Depression was measured using the Center for Epidemiological Studies Depression short form (CESD-8). Three types of social support from family, friends, and children were assessed: social support, social strain, and social contact. Autoregressive multiple regression was used to examine the relationship between change in depression, marital transitions, social support, and gender. Widowhood and social strain were independently associated with an increase in CESD-8 scores between 2012 and 2014. Significant interactions between social support and social strain, and separation\/divorce were identified, and the relationship between social support, depression, and divorce varied by gender. Change in depression was positively associated with social support for separated\/divorced females, but not separated\/divorced males. These results indicate that social support may modify the influence of divorce on changes in depression among recently divorced older females. These findings can help mental health service providers more effectively target older adults at the greatest risk of depression after experiencing a marital transition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":263939442,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/geroni\/igab046.3332","PubMedCentral":"8682065","ArXiv":null},"license":"CCBY","url":"https:\/\/academic.oup.com\/innovateage\/article-pdf\/5\/Supplement_1\/919\/43188898\/igab046.3332.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo analyze the effect of passive smoking of pregnancy women in early pregnancy and different stages during pregnancy on fetal Low-Birth-Weight.\n\n\nMETHODS\nMeta analysis was applied to analyze the relationship between maternal passive smoking during pregnancy and fetal low-birth-weight. NCBI, OVID-MEDLINE, CNKI, VIP and CBM were searched with the language limited to Chinese and English. The search was finished in April 2008. Pooled ORs with 95% CI were estimated.\n\n\nRESULTS\nTotally, 26 papers were got, including 20 cohort studies and 6 case-control studies. Maternal passive smoking was associated with an increased risk of low-birth-weight. The unadjusted pooled OR was 1.65 (95% CI = 1.39-1.97), and the adjusted pooled OR was 1.60 (95% Ci = 1.25 - 2.05). The pooled OR of exposure with lowest and highest level were OR = 1.53 (95% CI: 1.14 - 2.04)and OR = 2.53(95% CI: 1.46-4.36), respectively. The pooled OR of exposure at early pregnancy was 1.12 (95% CI = 0.82-1.55), with no statistically significance.\n\n\nCONCLUSION\nMaternal passive smoking during pregnancy could increase the risk of delivering a low birth-weight baby. Middle or late pregnancy might be the sensitive period of passive smoking's effect. Whether passive smoking' s threshold effect exists or not is still not sure.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20489933,"openaccessinfo":{"externalids":{"MAG":"2471940030","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Measurements of transverse profiles using Ionization Profile Monitors (IPMs) for high brightness beams may be affected by the electromagnetic field of the beam. This interaction may cause a distortion of the measured profile shape despite strong external magnetic field applied to impose limits on the transverse movement of electrons. The mechanisms leading to this distortion are discussed in detail. The distortion itself is described by means of analytic calculations for simplified beam distributions and a full simulation model for realistic distributions. Simple relation for minimum magnetic field scaling with beam parameters for avoiding profile distortions is presented. Further, application of machine learning algorithms to the problem of reconstructing the actual beam profile from distorted measured profile is presented. The obtained results show good agreement for tests on simulation data. The performance of these algorithms indicate that they could be very useful for operations of IPMs on high brightness beams or IPMs with weak magnetic field. \u2217 email@example.com 1 ar X iv :1 81 1. 00 37 1v 1 [ ph ys ic s. ac cph ] 1 N ov 2 01 8","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":53605595,"openaccessinfo":{"externalids":{"MAG":"2901620090","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The synthesis of new 1,3-phenylene derivatives and their preliminary evaluation as antivirals (Herpes simplex 1, HSV-1) whose antiherpetic activity can be related with the inhibition of the interaction of the origin binding protein (OBP) with the DNA are presented. The new compounds are adjusted to a previously defined common structural model, consisting of a central aromatic system, which presents two side chains of different lengths in relative position 1, 3; these chains are made up of atomic groups characterized by the alternation of positive and negative centers, situating differently substituted rings, preferably aromatic, at the ends of both chains. Some of these derivatives, such as N,N''-(4-methoxy-1,3-phenylene)bis[N'-(4-nitrophenyl)urea] (2c) or (1,3-phenylene)bis[N-(p-tolyl)aminosulfonyl] (11b), show antiherpetic activity related to the proposed mechanism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19939611,"openaccessinfo":{"externalids":{"MAG":"2415685984","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract This paper focuses on systems producing short rotation coppice willows (SRCW) in chickens' free-range areas. We aim to map chicken farmers' motivation to implement SRCW, and to assess the economic viability of these systems. Semi-structured interviews were conducted with 18 free-range chicken farmers. Farmers agreed that chickens would prefer SRCW over grassland, which could benefit chicken welfare. They expected establishing an SRCW system would be labor intensive, and doubted if it would be a profitable investment. Some concerns of farmers might be taken away by exchanging information with farmers with SRCW experience. A partial budget analysis was performed to calculate the net present value (NPV) of six different scenarios, differing in the type of chickens, in whether the produced biomass was sold or valorized on-farm and in harvest pattern, all over a 23-yr period. The NPV was positive but low for all scenarios. A sensitivity analysis showed that changes in biomass yield, wood chip price, a price premium for poultry products and current fuel price were most likely to influence the NPV. A risk analysis revealed that NPVs were positive in the majority of the modeled cases. Scenarios in which biomass was used for on-farm heat production showed the highest risk of a negative NPV. A price premium for poultry products may be most effective at increasing profitability, but may only be feasible for farms selling directly to consumers. Establishing a solid market for biomass energy, including guaranteed demand and availability of appropriate machinery for cultivation, may mitigate farmers' concerns.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":158287261,"openaccessinfo":{"externalids":{"MAG":"2900543484","ACL":null,"DOI":"10.1017\/S1742170518000546","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nCongenital histiocytosis is divided into four entities differing in their clinical and histological features and prognosis. Early, accurate diagnosis is essential for treatment.\n\n\nCASE REPORT\nSeven cutaneous nodules were seen in a male neonate. One of these nodules was biopsied on the 7th day of life; it showed the typical findings of Hashimoto-Pritzker reticulohistiocytosis by optical and electron microscopy using immunological markers. The nodules spontaneously disappeared after a few months.\n\n\nCONCLUSIONS\nCongenital forms of histiocytosis must be accurately characterized. Hashimoto-Pritzker reticulohistiocytosis is a benign and self-healing disease restricted to the skin, while the Letterer-Siwe disease has a completely different course and treatment.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37404081,"openaccessinfo":{"externalids":{"MAG":"2411629640","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective This systematic review aims to synthesize and analyze the available literature on central nervous system (CNS) magnetic resonance imaging (MRI) findings in individuals who have received COVID-19 vaccinations. Our objective is to enhance understanding of potential neurological side effects, inform clinical practice, and guide future research on the neurological implications of COVID-19 vaccination. Methods In this systematic review, we conducted a comprehensive search in PubMed, Scopus, and Web of Science from January 2020 to April 2023, using terms related to COVID-19 vaccination and CNS MRI findings. We evaluated the quality of the study, extracted relevant data, and included 89 eligible studies that covered various vaccines, demographics of patients, symptoms, and MRI findings to provide a thorough understanding of SARS-CoV-2 vaccination-related CNS problems. Results We investigated CNS MRI findings following COVID-19 vaccination across various vaccine types. Common diseases associated with post-vaccination CNS MRI findings included cerebral venous sinus thrombosis (CVST), vaccine-induced immune thrombotic thrombocytopenia (VITT), acute disseminated encephalomyelitis (ADEM), acute myelitis, autoimmune encephalitis (AE), and others. Patients presented with diverse onset symptoms and neurological manifestations. Abnormalities identified in CNS MRI findings included white matter (WM) hyperintensity. Our analysis offers a comprehensive overview of the current literature on post-vaccination CNS MRI findings. Discussion. We highlight a range of post-COVID-19 vaccination CNS MRI findings, including CVST, with a higher incidence in individuals receiving the ChAdOx1 (AstraZeneca) vaccine. Other notable observations include cases of ADEM, myelitis or transverse myelitis (TM), Guillain\u2013Barr\u00e9 syndrome (GBS), and acute encephalopathy following COVID-19 vaccination. The incidence of these neurological complications is extremely rare, and the benefits of vaccination outweigh the risks. The reviewed studies were primarily case reports or case series, and thus large-scale epidemiological studies and controlled clinical trials are needed to better understand the underlying mechanisms and risk factors associated with these neurological complications following COVID-19 vaccination.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259310991,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1155\/2023\/1570830","PubMedCentral":"10325882","ArXiv":null},"license":"CCBY","url":"https:\/\/downloads.hindawi.com\/journals\/cjidmm\/2023\/1570830.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Glioblastoma (GBM) is the most common brain tumor, with rapid proliferation and fatal invasiveness. Large-scale genetic and epigenetic profiling studies have identified targets among molecular subgroups, yet agents developed against these targets have failed in late clinical development. We obtained the genomic and clinical data of GBM patients from the Chinese Glioma Genome Atlas (CGGA) and performed the least absolute shrinkage and selection operator (LASSO) Cox analysis to establish a risk model incorporating 17 genes in the CGGA693 RNA-seq cohort. This risk model was successfully validated using the CGGA325 validation set. Based on Cox regression analysis, this risk model may be an independent indicator of clinical efficacy. We also developed a survival nomogram prediction model that combines the clinical features of OS. To determine the novel classification based on the risk model, we classified the patients into two clusters using ConsensusClusterPlus, and evaluated the tumor immune environment with ESTIMATE and CIBERSORT. We also constructed clinical traits-related and co-expression modules through WGCNA analysis. We identified eight genes (ANKRD20A4, CLOCK, CNTRL, ICA1, LARP4B, RASA2, RPS6, and SET) in the blue module and three genes (MSH2, ZBTB34, and DDX31) in the turquoise module. Based on the public website TCGA, two biomarkers were significantly associated with poorer OS. Finally, through GSCALite, we re-evaluated the prognostic value of the essential biomarkers and verified MSH2 as a hub biomarker.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":251448648,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fgene.2022.900911","PubMedCentral":"9399759","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2022.900911\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Abstract Objective: Previous studies have shown that progesterone receptor membrane component 1 (PGRMC1) expressed in breast cancer tissue can predict a worse prognosis for breast cancer patients. Moreover, we demonstrated that PGRMC1 can increase the proliferation of progestogens. However, the role of PGRMC1 in terms of estrogen-induced proliferation and comparing different estrogens is still unclear. Methods: Non-transfected and PGRMC1-transfected T-47D cells were stimulated with estradiol (E2), with equilin (EQ), or with ethinylestradiol (EE) at 1, 10, and 100\u2009nmol\/l. Increase of proliferation was compared with a control (without estrogens) and with the estrogen-induced stimulation in empty vector cells vs. PGRMC1-transfected cells. Results: The empty vector cells showed significant proliferation (12\u201315%) with all three estrogens only at the highest concentration, with no relevant differences between the estrogens. PGRMC1-transfected cells showed about three-fold higher proliferation (29\u201366%), whereby E2 elicited the strongest and EE the lowest proliferating effects, significantly lower compared to E2 and also compared to EQ. No significant differences were seen between E2 and EQ. Conclusions: PGRMC1 increases strongly the estrogen-dependent breast cell proliferation. The proliferating effects of EE may be lower compared to E2 and EQ. This could have importance in comparing hormone therapy and contraception. Thus, PGRMC1 not only could predict the risk using progestogens but also of different estrogens.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":76665553,"openaccessinfo":{"externalids":{"MAG":"2920959064","ACL":null,"DOI":"10.1080\/13697137.2019.1582624","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"AIMS\/HYPOTHESIS\nInhibition of the signalling function of the human insulin receptor (HIR) is one of the principle mechanisms which induce cellular insulin resistance. It is speculated that serine residues in the insulin receptor beta-subunit are involved in receptor inhibition either as inhibitory phosphorylation sites or as part of receptor domains which bind inhibitory proteins or tyrosine phosphatases. As reported earlier we prepared 16 serine to alanine point mutations of the HIR and found that serine to alanine mutants HIR-994 and HIR-1023\/25 showed increased tyrosine autophosphorylation when expressed in human embryonic kidney (HEK) 293 cells. In this study we examined whether these mutant receptors have a different susceptibility to inhibition by serine kinases or an altered tyrosine kinase activity.\n\n\nMETHODS\nTyrosine kinase assay and transfection studies.\n\n\nRESULTS\nIn an in vitro kinase assay using IRS-1 as a substrate we could detect a higher intrinsic tyrosine kinase activity of both receptor constructs. Additionally, a higher capacity to phosphorylate the adapter protein Shc in intact cells was seen. To test the inhibition by serine kinases, the receptor constructs were expressed in HEK 293 cells together with IRS-1 and protein kinase C isoforms beta2 and theta. Phorbol ester stimulation of these cells reduced wild-type receptor autophosphorylation to 58 % or 55 % of the insulin simulated state, respectively. This inhibitory effect was not observed with HIR-994 and HIR-1023\/25, although all other tested HIR mutants showed similar inhibition induced by protein kinase C.\n\n\nCONCLUSION\/INTERPRETATION\nThe data suggest that the HIR-domain which contains the serine residues 994 and 1023\/25 is important for the inhibitory effect of protein kinase C isoforms beta2 and theta on insulin receptor autophosphorylation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25767504,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Job satisfaction and organizational justice one of the topics which neglected in the context of Middle East countries in general and particularly in Iraq. The study aims to find the effect of organizational justice on job satisfaction among secondary schools' teachers and enrich the body of knowledge in Iraq and the Middle East countries. The study conducted in 8 secondary schools in Heet city province of Anbar, Iraq, 98 valid questionnaires were analysed by SPSS. The results showed the components of organizational justice's distributive justice and interactional justice are positively affect on job satisfaction. However, distributive justice found a high effect on Job satisfaction. While, Procedural justice found non-significant effect on job satisfaction may because of the environment and policy of public schools in Iraq which is directly related to government policy in case of, promotions, salary and employment etc. This result helps school's administration to manage the schools and understand teachers desire better than before. Meanwhile, teachers, when feel treated fairly from school administration and the rewards are distributed fairly and equitable in the school will lead to increase job satisfaction and could increase their productivity and performance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":213951195,"openaccessinfo":{"externalids":{"MAG":"3008386748","ACL":null,"DOI":"10.37200\/ijpr\/v24i3\/pr200880","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Motivated by a neuroscience question about synchrony detection in spike train analysis, we deal with the independence testing problem for point processes. We introduce non-parametric test statistics, which are rescaled general $U$-statistics, whose corresponding critical values are constructed from bootstrap and randomization\/permutation approaches, making as few assumptions as possible on the underlying distribution of the point processes. We derive general consistency results for the bootstrap and for the permutation w.r.t. to Wasserstein's metric, which induce weak convergence as well as convergence of second order moments. The obtained bootstrap or permutation independence tests are thus proved to be asymptotically of the prescribed size, and to be consistent against any reasonable alternative. A simulation study is performed to illustrate the derived theoretical results, and to compare the performance of our new tests with existing ones in the neuroscientific literature.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":1613584,"openaccessinfo":{"externalids":{"MAG":"1821443939","ACL":null,"DOI":"10.1214\/15-AOS1351","PubMedCentral":null,"ArXiv":"1406.1643"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Among the neuropsychiatric symptoms in Parkinson's disease (PD) patients, hallucination can result from the disease itself or medical treatment. Hallucination associated with subthalamic nucleus stimulation (STN-DBS) has been reported; however, it is still unclear whether PD patients with a history of hallucination are appropriate candidates for STN-DBS or not. Aims: We investigated the effect of STN-DBS on preexisting hallucination associated with advanced PD. Methods: Eighteen STN-DBS patients were investigated retrospectively. The severity of hallucination was assessed by the thought disorder score on the Unified Parkinson's Disease Rating Scale (UPDRS, part 1-item 2) in the patients' interviews; the score 6 months after the initiation of STN-DBS was compared with the highest score throughout the preoperative history and the score 2 weeks before surgery. Results: Hoehn-Yahr stage and motor score (UPDRS part 3) were significantly improved following STN-DBS. Six months after the initiation of STN-DBS, the severity of hallucination, assessed by thought disorder score, did not increase, but rather decreased compared with the preoperative level (p < 0.05 by McNemar's test). The daily levodopa equivalent dose was increased in 2 patients without the development of hallucination. On the other hand, anti-parkinsonian drugs were totally withdrawn in 1 patient, but without improvement of hallucination. Conclusions: Our findings indicate that STN-DBS surgery does not always lead to deterioration of preexisting hallucination in PD. In advanced PD, hallucination involves a multifactorial pathogenesis and a history of hallucination is not a contraindication to STN-DBS surgery.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-26":1}},"corpusid":12508790,"openaccessinfo":{"externalids":{"MAG":"1981839736","ACL":null,"DOI":"10.1159\/000195719","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The efficacy and tolerability of felodipine, in a low dose of 5-10 mg daily was assessed in 32 patients with mild-to-moderate hypertension, aged 53 +\/- 11 years. The results of office vs 24 h ambulatory blood pressure measurements (ABPM) were compared. Inclusion criteria included an office systolic and diastolic blood pressure (SBP\/DBP) > 140\/90 mm Hg and a 24 h ABPM SBP\/DBP > 135\/85 mm Hg. Felodipine was initiated at a dose of 5 mg daily. At day 28 of the study, if office DBP > 90 mm Hg, the dose was doubled to 10 mg daily. At the end of the study (day 84), 24 h ABPM was done again. Side effects were noted throughout the study. Four patients dropped out during the study (two due to headache, one due to pedal edema and one rejected further participation). Of the remaining 28 patients, at day 28, 12 required an increased dose of 10 mg\/day. At the end of the study, office BP was below 140 90 mm Hg in 71% of the patients. In the whole group BP decreased from 158 +\/- 15\/101 +\/- 8.4 to 138 +\/- 9\/85 +\/- 5 mm Hg, P < 0.001. ABPM showed that BP was normalized in 82% of the patients. It decreased from 146.8 +\/- 9.56\/94.8 +\/- 7.4 to 130.2 +\/- 10.6\/83 +\/- 6.3 mm Hg, P < 0.001. BP was similarly reduced in working and sleeping hours, with preservation of the circadian rhythm. Heart rate was unaffected by the drug. Five patients showed persistently elevated SBP on office measurements while on ABPM, the values were within normal limits. This finding confirms the existence of a white coat effect in patients with proven hypertension and the superiority of ABPM over office BP measurements in clinical investigations. In summary, ABPM showed that the antihypertensive effect of felodipine was sustained throughout normal 24 h, including the critical (as regards cardiovascular morbidity) awakening hours.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23181642,"openaccessinfo":{"externalids":{"MAG":"135828323","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper tries to discuss the efforts of geographers of science to put science in its geographical contexts. Geographers of science have studied the socio-spatial settings in which scientific knowledge has been generated, displayed, and legitimated. For them, science is socially constructed in \"spatialities\" and \"temporalities\". The major question of this study is how \"spatialities\" construct scientific knowledge via its \"causalities\". The fundamental idea is that geography of science does not only deal with places, locations, and regions where scientific knowledge is produced or distributed; it also deals with a variety set of spatial causalities through which scientific knowledge can be formed and transformed. This means that the development of innovative knowledge and ideas take place not only within a spatial context but also occur due to the spatial causalities associated with the myriad interlinkages and interdependencies among places. These imperatives of spatial significance operate across many spatial scales from body\/local to the planet\/global. Hence, in our increasingly globalized world, we must seek knowledge in spatial encounters and in-between places, not merely within spaces and places. In addition, when we are living in an unprecedented transformation period which transfers the terrestrial spatial causalities to the virtual spatial causalities via intelligent and digital technologies, we should be more aware of the difference that new algorithms make in our daily life through hacking virtual spatial causalities.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":244060307,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48088\/ejg.m.sho.12.3.129.145","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.48088\/ejg.m.sho.12.3.129.145","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"In this note, we investigate some problems concerning the set of I_3I 3\u2013\\lambda\u03bb-statistical cluster points of triple sequences via ideals in finite dimensional spaces, and some of its properties in finite dimensional Banach spaces are proved.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":255244213,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.56405\/dngcrj.2022.07.01.02","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"http:\/\/dngcrj.dngc.ac.in\/wp-content\/uploads\/2022\/12\/DNGCRJ-2022-07-01-02.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Aeromagnetic and airborne gravity data acquired over part of the Baram Basin, Sarawak, Malaysia, was used to estimate depth to economic basement that is the Top Cretaceous (Horizon-1), and depth to three intra-sedimentary horizons: Top and Base of Carbonates (Horizon-2 and Horizon-3), and the top of an additional shallower interface (Horizon- 4). Depths to these horizons were calculated through the analysis of energy spectra of the observed magnetic and gravity fields, while faults and magnetic lineaments were derived through the application of an automatic curve matching (ACM) method based on the Naudy technique. The project involved the application of a new spectral technique, termed the Multi-Window-Test (MWT). The application of the MWT allowed quick estimation of depth to multiple horizons (skeleton maps) and also provided a set of optimal window sizes used for detailed mapping. The potential field derived results correlate well with both seismic and well data. Spectral methods have been successfully applied in the Baram Basin, and the MWT has proved itself a valuable tool in producing a robust interpretation of potential field data.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":134898870,"openaccessinfo":{"externalids":{"MAG":"2800221708","ACL":null,"DOI":"10.1190\/sbgf2011-146","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Different discourses on teacher training can be identified throughout the history of Chili. A recent form of teacher training is mentoring, in which an experienced teacher works together with a teacher who has just entered the school system. Based on a Foucauldian perspective, this paper presents a discursive analysis of the systematization of a pilot mentoring program carried out in two regions of Chile. It appears that the horizons of possibilities from which the practices of this experience have emerged form a discourse of training where teachers should be able to manage their own work and teacher development should be an individual enterprise. Such horizons of possibilities promote certain kinds of mentoring practices, such as reflection of the individual work of teachers within their own classrooms; but limit others, such as collective reflection on educational policies.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":143684889,"openaccessinfo":{"externalids":{"MAG":"2946439671","ACL":null,"DOI":"10.1590\/S0101-73302011000400014","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Uterine blood flow has been measured with a chronically implanted miniature electromegnetic flow meter in unanesthetized pregnant sheep and dogs during spontaneous and oxytocin induced labor and followed in the same animal for several postpartum days. In either spontaneous or oxytocin induced labor, uterine contractions are accompanied by a significant decrease in uterine blood flow and relaxations by the return of the flow to or higher than control values. The decrease is roughly proportional to the intensity of uterine contraction. When the contraction is of a tetanic nature and not followed by relaxation, uterine ischemia is so severe that the fetus might succumb. After the delivery of the fetus and before the expulsion of the placenta, uterine blood flow falls slightly. However, after separation and expulsion of the placenta, uterine blood flow falls precipitously. Thereafter, a very slight and progressive decrease continues for several days paralleling uterine involution.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":21528906,"openaccessinfo":{"externalids":{"MAG":"2268469675","ACL":null,"DOI":"10.1152\/AJPLEGACY.1958.195.3.614","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper is concerned with the problems pertaining to the implementation of the State Union-Republic program of urgent measures for 1990-1992 and Republican programs of the elimination of Chernobyl accident consequences. Among the basic priorities covered by the program, the author regards the problems of the living of the population at the polluted areas, criteria for accepting decisions as to the possibility of further living or settling out together with favourable and unfavourable consequences of such a measure as settling out. Emphasis is laid on some priorities of the optimal use of means alloted for implementing the programs of the elimination of Chernobyl accident consequences.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36500923,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A passive sampling device previously developed was used to assess environmental contamination. It consists of a polymeric bag filled with an organic solvent in which contaminants are preconcentrated after passively diffusing from the water column. The contents of the device were subjected to analysis without further cleanup. The effect of temperature, turbulence, ionic strength, pH, and the presence of dissolved organic material on the partioning process were examined. The results showed that increase in temperature supply the molecules with greater energy and enables them to pass through the membrane and into the solvent. Turbulence was found to disrupt the boundary layer formed around the device as a result of concentration polarization causing irregular fluctuations in the concentration of contaminants in equilibrium with the membrane. There was no discernable correlation between the concentration of contaminants accumulated by the devices and the ionic strength of the incubation solution. There was also no discernable relationship between pH and contaminants uptake by the sampling devices as was expected with non polar, non-ioniseable solutes. The uptake of compounds with lower molar volumes was most susceptible to the presence oh humic materials. Journal of Applied Sciences and Environmental Management Vol. 10(1) 2006: 15-23","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":95313653,"openaccessinfo":{"externalids":{"MAG":"2040940643","ACL":null,"DOI":"10.4314\/JASEM.V10I1.17298","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Violet collinsia (Collinsia violacea) is a winter annual ranging primarily from Missouri to Kansas. An isolated population occurs in central Illinois, 200 km from the nearest Missouri population, in a series of colonies on adjoining river bluffs. Its oak woodland habitat was undergoing vegetation changes consistent with mesophication including establishment of a subcanopy of sugar maple (Acer saccharum). We conducted a field study on one Illinois colony to determine violet collinsia response to early dormant-season fire and to test whether this species might be limited by leaf litter accumulation or absence of fire stimulus. We collected baseline data on plant density and frequency using a stratified-random grid of 72 plots (0.5 m2) overlaying the colony. We applied two experimental treatments, fire and leaf litter removal, and a no-treatment control, each with 24 replicates. We used a sheet-metal burn box in the replicate burn plots and a garden rake in leaf-litter removal plots. Only the burn plots had significant changes immediately following treatments, increasing tenfold (12 to 123 plants) between the baseline and post-treatment growing season, and increasing in frequency from 17% to 67%. Post-treatment monitoring indicated there were no carry-over treatment effects. Violet collinsia appears to be a fire-annual with the capacity for persistence in soil seed banks. Following the experiment, a prescribed burn implemented throughout the study unit during the early dormant season also yielded a tenfold increase in the colony.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":85427140,"openaccessinfo":{"externalids":{"MAG":"2060969047","ACL":null,"DOI":"10.3368\/er.31.1.57","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this work we studied influence of crystallinity on relaxation processes in thermoplastic polyimides based on 1,3-bis(3',4-dicarboxyphenoxy)benzene (dianhydride R) and diamine 4,4'-bis-(4\"-aminophenoxy)biphenyl (BAPB diamine) by the methods of termoactivation spectroscopy (TSDC) and dynamic mechanical analysis (DMA). The dipole-group relaxation (\u03b2), space charge relaxation (\u03b2') and dipole-segmental relaxation (\u03b1) were detected in the spectra of TSDC. The analysis of DMA and TDSC data shows that they correlate with each other. The activation energy of \u03b1, \u03b2, \u03b2' relaxation maxima were calculated by the computer modeling method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54387252,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/icd.2018.8514571","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Reanimation of a spontaneous and synchronous smile, and sufficient depressor mechanism of the lower lip presents a surgical challenge in facial paralysis. Hypoglossal-facial nerve crossover and cross-facial nerve grafting are the best options if the mimetic muscles around the mouth are still viable in patients in whom the facial nerve was sacrificed at the brainstem. Although good muscle tone and facial motion have been obtained by hypoglossal-facial nerve crossover, smile is dependent on conscious tongue movement. Cross-facial nerve grafting provides a voluntary and emotion-driven smile, but requires two coaptation sites, which leads to substantial axonal loss and a long regeneration time. This method was not successful in activating the depressor mechanism. The first stage is the classic \"baby-sitting\" procedure, in which the bulk of the mimetic muscles was maintained by the rapid reinnervation of the hypoglossal-facial nerve crossover during the regeneration period of the cross-facial nerve graft, and temporalis muscle transfer to the eyelids is performed. During the second stage, the cross-facial nerve graft that used the thickest zygomaticobuccal branch on the healthy side was coapted with the corresponding branches on the paralyzed side. The hypoglossal-facial nerve crossover continued to innervate the depressor muscles. Good spontaneous smile and sufficient depressor mechanism were achieved by cross-facial nerve grafting and hypoglossal-facial nerve crossover respectively, and these techniques are demonstrated by the authors clinically and electrophysiologically.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":32183206,"openaccessinfo":{"externalids":{"MAG":"2063240679","ACL":null,"DOI":"10.1097\/00000637-200103000-00017","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The following interview with Christine Pickering, an instructor of English as a foreign language at Duksung Women's University, Seoul, South Korea, discusses teaching English to North Korean refugees with People for Successful Corean Reunification (PSCORE). A non-profit nongovernmental organization and human rights-national unification initiative, PSCORE was founded in 2006 in Seoul and has an office in Washington, D.C., with support from the U.S. State Department. PSCORE offers a one-on-one education program and free volunteer tutoring in computers, languages, mathematics, and other subjects, serving some 140 North Korean refugees as they adjust to life and employment competition in South Korea. The interviewers thank Mr. Bada Nam, PSCORE secretary general, and Ms. Jeongeun Ahn, PSCORE research manager, for approving the interview. The interview questions were prepared by Alzo David-West, and the interview was conducted in person by Sora Suh on August 1, 2012, at a PSCORE teaching location in Seoul. All personal names of North Korean refugee students have been removed.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":145408070,"openaccessinfo":{"externalids":{"MAG":"2141997490","ACL":null,"DOI":"10.1017\/S0266078414000078","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many textbooks and review articles fully explain the fundamental principles of functional magnetic resonance imaging (fMRI); therefore, I shall give only a brief description. As with most neuroimaging techniques, fMRI is a method for determining which parts of the brain are activated by different types of physical sensation or activity, such as sight, sound, or movement of a subject, as well as areas responding to cognitive tasks and activation by other means (such as drug administration). The MR signal on fMRI images is strongly influenced by the oxygenation state of the blood (blood oxygen level dependency [BOLD]), and this dependency is harnessed in fMRI. Therefore, precise changes in brain activation or metabolism are not directly observed with fMRI, but the effects of local increases in blood flow and microvascular oxygenation in the region of activation are mapped as a change in raw image intensity. The spatial resolution on high field systems (currently 3 or 4 Tesla) for whole-brain imaging is commonly 3 mm \u00d7 3 mm \u00d7 6 mm, but it is feasible to collect data at higher spatial resolution by focusing specifically on one area of interest. The temporal resolution is approximately 2.5 seconds for one data point (i.e., coverage of the whole brain every 2.5 seconds), allowing for great flexibility in experimental design compared with other neuroimaging methods. In summary, this \"brain mapping\" is achieved by setting up an advanced MRI scanner in a special way so that the increased blood flow to the neurally active region of the brain shows up on fMRI scans. Pharmacological MRI (or phMRI) is simply the combination of administering drugs with the collection of fMRI data, and although this nomenclature is becoming widely used, it is not yet fully accepted as the only term for combining drugs with fMRI studies. One can determine either direct modulation of brain function through centrally acting drugs or indirect modulation of brain activation by altered afferent input after treatment with peripherally acting drugs. Most work to date has focused on acute administration of centrally acting drugs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":13202469,"openaccessinfo":{"externalids":{"MAG":"2059882435","ACL":null,"DOI":"10.1177\/0091270001417005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"UNLABELLED\nPortal hypertension is the main cause of complications of hepatic diseases determining portosystemic collateral circulation, ascites and gastroesophageal varices. Aim of the study is to review current opinions and to correlate clinical and endoscopic signs determined by portal hypertension.\n\n\nMATERIAL AND METHODS\nWe performed a retrospective study on 150 patients diagnosed and treated for diseases associated with portal hypertension at the Institute of Hepatology and Gastroenterology from Ia\u015fi between 2007 and 2009.\n\n\nRESULTS AND DISCUSSION\nMost of the patients presented with cirrhosis (112 cases) mainly of toxic (63 cases) and viral (31 cases) etiology. In order to appreciate bleeding from esophageal varices we applied Forrest criteria and identified type Ia bleeding in 26,6% of cases and type Ib bleeding at 73,4% of patients. In 15% of cases, variceal bleeding represented the first symptom of slowly progressing hepatic cirrhosis.\n\n\nCONCLUSIONS\nThe objective of subsequent evaluation of small varices is detecting size increase, an important prognostic and therapeutic index.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":35970857,"openaccessinfo":{"externalids":{"MAG":"2415437190","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. Modern records of 165 species of wetland beetle (Haliplidae, Hygrobiidae, Noteridae, Dytiscidae, Gyrinidae, Georissidae, Hydrochidae, Helophoridae, Hydrophilidae, Hydraenidae, Scirtidae, Dryopidae, Elmidae, Chrysomelidae, Curculionidae) were assembled for analysis. \n \n \n \n2. Two hundred and eighty nine modern lists of seven or more species of water beetle from sites in Ireland were subjected to multivariate analysis. \n \n \n \n3. Ten assemblage types were identified using TWINSPAN. Habitats typical of these assemblages are: A. deep rivers; B. rivers with riffles; C. puddles; D. canals and lakes with rich vegetation; E. ponds and ditches; F. turloughs; G. natural, minerotrophic fens; H. base-flushed cutover bogs; I. peat bogs; J. montane flushes. The distribution of these types is discussed. \n \n \n \n4. Ordination of site data by DECORANA indicated that the important environmental variables dictating water beetle assemblage type in Ireland were: flow; water permanence; exposure; type of substratum. Acidity could not be isolated as a determinant, except within the analysis of assemblage types conducted using TWINSPAN. DECORANA isolated one brackish site as an outlier but salinity was not otherwise a major factor, probably because few brackish sites were included in the analysis. \n \n \n \n5. The number of modern records for each species was used to provide a provisional set of species-quality scores. A simple rationale was devised to weight these scores in favour of relict species and against elusive species, species with short-lived adults and species primarily associated with man-made habitats. \n \n \n \n6. The average species-quality score per site and the number of species recorded were used to rank sites within each TWINSPAN end-group. The most diverse sites with the highest quality were some turloughs, rich fens and base-flushed peat cutting complexes. Some montane lakes and flushes with relatively few species had high species-quality scores.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":85342859,"openaccessinfo":{"externalids":{"MAG":"2075964415","ACL":null,"DOI":"10.1002\/AQC.3270020205","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\"We live in an age of uncertainty\u2014an age that evokes both a sense of hope and one of deep concern. It is a time of hope because, perhaps like never before, we are witness to so many distinct efforts to shape a better and more peaceful world for all. We see governments joining hands to enhance the well-being of citizens and the global community through shared knowledge and technology, common markets, and commitments to environmental protection. We also hear myriad civil society voices standing shoulder-to-shoulder with governments for a more humane society and a secure planet.\" from Text","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":153214622,"openaccessinfo":{"externalids":{"MAG":"1541082963","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Plant Physiology is a compulsory specialized fundamental course, and plays an important role in the whole education of plant-related majors in agricultural institutions. In order to improve the educational effects and train specialized students in agriculture, the methods in plant physiology teaching in Qingdao Agricultural University are summarized in this paper. The results will provide a reference for improving the teaching of Plant Physiology in the futurei\u00bc\u017d","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":132740129,"openaccessinfo":{"externalids":{"MAG":"2544525999","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since the publication of Schlagenhaufer's work in 1913, studies of gastro-intestinal lymphogranulomatosis, particularly of the localized type, have been made from the clinical and pathologic points of view, and from these the basis of the present conception regarding this type of Hodgkin's disease has been formed. Cases of Hodgkin's disease of this type warrant particular attention as the formulation of the correct clinical diagnosis is extremely difficult, notwithstanding the numerous laboratory procedures available. The diagnosis is usually made after operation or at necropsy on the basis of the histologic picture and not on that of the gross anatomic features, which cannot be differentiated from those of other pathologic conditions. Two additional cases are here presented, and an analysis is made of the available clinical data regarding seventy-three cases reported in the literature. In 1889 Pitt described lesions in the stomach and duodenum as part of generalized Hodgkin's disease. Wells and","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":71703425,"openaccessinfo":{"externalids":{"MAG":"1977850387","ACL":null,"DOI":"10.1001\/ARCHINTE.1938.00180070065005","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Streptococcus sanguinis is a ubiquitous commensal species of the oral cavity commonly involved as an opportunistic pathogen in cardiovascular infections. In this study, we investigated the functions of endopeptidase O (PepO) and a C3-degrading protease (CppA) in the systemic virulence of S. sanguinis. Isogenic mutants of pepO and cppA obtained in strain SK36 showed increased susceptibility to C3b deposition and to opsonophagocytosis by human polymorphonuclear neutrophils (PMN). These mutants differ, however, in their profiles of binding to serum amyloid P component (SAP) and C1q, whereas both showed reduced interaction with C4b-binding protein (C4BP) and\/or factor H (FH) regulators as compared to SK36. The two mutants showed defects in ex vivo persistence in human blood, serum-mediated invasion of HCAEC endothelial cells, and virulence in a Galleria mellonella infection model. The transcriptional activities of pepO and cppA, assessed by RT-qPCR in nine wild-type strains, further indicated strain-specific profiles of pepO\/cppA expression. Moreover, non-conserved amino acid substitutions were detected among the strains, mostly in CppA. Phylogenetic comparisons with homologues of streptococcal species of the oral and oropharyngeal sites suggested that S. sanguinis PepO and CppA have independent ancestralities. Thus, this study showed that PepO and CppA are complement evasion proteins expressed by S. sanguinis in a strain-specific manner, which are required for multiple functions associated with cardiovascular virulence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260807648,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/21505594.2023.2239519","PubMedCentral":"10424592","ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/21505594.2023.2239519?needAccess=true&role=button","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Clusters of atypical absence, myoclonic seizures and tonic seizures developed in a thirteen-year-old boy with Lennox-Gastaut syndrome. As conventional antiepileptic drugs failed to eliminate the seizures, we treated the patient with continuous intravenous lidocaine (4 mg\/kg\/hr). The treatment reduced the duration of paroxysmal discharges (spike-wave complexes and rapid rhythm) from 3 sec\/min to 0.7 sec\/min, monitored by EEG. Oral mexiletine (5.4 mg\/kg\/day) following the lidocaine treatment has maintained good seizure control for two years with no adverse effects, and improved his behavioral problem. The treatment with lidocaine followed by mexiletine was useful for controlling clusters of intractable seizures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3482713,"openaccessinfo":{"externalids":{"MAG":"2407381557","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Based on Fan Jianqing's research, it has some discussion about the large sample characteristics of Local Linear Smoothing Estimator in conditions of both discrete and continuous time samples. Also by extending the Borel-Cantelli Lemma in continuous time samples, it is concluded that this estimator owes the a.s. convergence in continuous time samples.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209841355,"openaccessinfo":{"externalids":{"MAG":"2252636280","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background Step-Down Intermediate Care (IC) was developed in Glasgow City and implemented in November 2014. IC units act as a bridging service between hospital and home, for those deemed medically fit for discharge, but who would otherwise spend some time delayed in hospital, usually due to a lack of appropriate care, support or accommodation in the community. The aim of this study was to measure the effect of IC on days delayed. Methods Rate of days delayed per 1000 population aged 75 years+ in Glasgow City was compared before and after onset of IC with a 6\u2009month phase-in period, using segmented linear regression with 23-month (January 2013\u2013November 2014) pre- and 13-month (June 2015\u2013June 2016) post- intervention periods. Rate of delayed days for residents of Inverclyde and West Dunbartonshire (I&WD)- areas with similar high levels of deprivation, within NHS GGC, but with no IC in place \u2013 were used as a comparison group, as in April 2015 a national target was set to reduce delays. Results Between January 2013 and November 2014 rate of days delayed in hospital increased by 41%. Rate of days delayed in I&WD was approximately half that of Glasgow at the start of the study period, however these also increased in the pre intervention period, by 33%. Rates reduced in both areas between November 2014 and June 2015. After accounting for secular changes pre-intervention, Glasgow City saw a level change of \u221257.66 (-60.85, \u201354.48) days per 1000 population with no significant change in trend, 0.35 (-0.19, 0.88). However, following adjustment for changes in I&WD, and therefore a factoring out of the new national target, the impact of IC in Glasgow City was found to be a level change of \u221212.56 (-17.65, \u20137.47) and a trend change of \u22120.38 (\u22120.73, \u20130.04). This is equivalent to a predicted reduction due to IC of \u22127.28 days delayed per 1000 popn, in June 2016, and a relative reduction of 18%. Rate of days delayed in Glasgow City continued to increase over time after the introduction of IC, though at a slower rate than if IC had not existed. Conclusion The introduction of a national target resulted in a reduction of delayed days. After factoring out this reduction, IC was responsible for a further reduction in delayed days of 18%. The rate of days delayed continued to increase over time after the introduction of IC, though at a slower rate.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":81622789,"openaccessinfo":{"externalids":{"MAG":"2903710495","ACL":null,"DOI":"10.1136\/jech-2018-SSMabstracts.176","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Organic anion transporting polypeptide 2B1 (OATP2B1), which is highly expressed in enterocytes and hepatocytes could be a key determinant for the intestinal absorption and hepatic uptake of its substrates, most of which are amphipathic organic anions. Tryptophan residues may possess a multitude of functions for a transport protein through aromatic interactions, such as maintaining the proper protein structure, guiding the depth of membrane insertion, or interacting directly with substrates. There are totally six tryptophan residues in OATP2B1. However, little is known about their role in the function and expression of OATP2B1. Our results show that, while W272, W276, and W277 located at the border of extracellular loop 3 and transmembrane domain 6 exhibit a moderate effect on the surface expression of OATP2B1, W611 located at the middle of transmembrane domain 11 plays a critical role in the function of OATP2B1. The tryptophan-to-alanine mutation of W611 changes the kinetic characteristics of OATP2B1-mediated estrone-3-sulfate (E3S) transport radically, from a monophasic saturation curve (with Km and Vmax values being of 7.1 \u00b1 1.1 \u03bcM and 182 \u00b1 7 pmol\/normalized mg\/min, respectively) to a linear curve. Replacing alanine with a phenylalanine will rescue most of OATP2B1's function, suggesting that the aromatic side chain of residue 611 is very important. However, hydrogen-bond forming and positively charged groups at this position are not favorable. The important role of W611 is not substrate-dependent. Molecular modeling indicates that the side chain of W611 faces toward the substrate translocation pathway and might interact with substrates directly. Taken together, our findings reveal that W611 is critical for the function of OATP2B1.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1422576,"openaccessinfo":{"externalids":{"MAG":"2512565047","ACL":null,"DOI":"10.1021\/ACS.MOLPHARMACEUT.6B00648","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract \n \nMany students' failures in perceiving the information from their teacher are caused by the unsuitability of communication style between teacher and students. It means that if a teacher has appropriate style in transferring information to the students, all subjects, including citizenship, will be easily understood. Indirectly, The fun style of teacher can improve the spirit or motivation of students in learning the materials given. Learning motivation of students can be arisen from the objective or encouragement to gain the expected results. This research aimed to study the effects of communication style of the teacher of Citizenship in motivating grade 8 students of Junior High Shool 3 of Wonogiri. The reseracher took 50 students of grade 8 in Junior High School 3 of Wonogiri as the samples of the research. The data analysis applied simple linear regression analysis. Data results showed that the communication style of teacher had significant influence in motivating learning motivation of grade 8 students of Junior High school 3 of Wonogiri so that it can be concluded that the style of communication of teacher took effect significantly in motivating learning motivation of students. However, data showed that there was only 28.2% of the learning motivation coming from the teacher's style of communication and the rest (71.8%) came from other factors such as internal and external factors (society, family). \n \nKeywords: The teacher's communication style, learning motivation of students, theory of subject-spesific motivation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149761887,"openaccessinfo":{"externalids":{"MAG":"2900372774","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Disproportionality research has been subject to multiple reviews, but there has been less critical examination of the policy dimension of this enduring educational problem. Given the relevance of federal policies, and interpretations thereof, to educators' and scholars' conceptualization of disproportionality and schools' resultant policies and practices, we provide a brief overview of disproportionality scholarship before focusing on its policy dimensions. We describe the role of federal policy and resultant interpretations to how disproportionality is addressed and our approach to identifying and synthesizing these interpretations. We then analyze the themes apparent in these interpretations: requirements for states' numerical analysis of \"significant disproportionality,\" parameters for school systems' allocation of resources for early intervening services when significant disproportionality is found, and schools' obligations for nondiscriminatory application of policies and procedures. Finally, we distill implications for school policies, practices, and procedures. We close with discussion of implications for how disproportionality is conceptualized and studied.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":150542801,"openaccessinfo":{"externalids":{"MAG":"2913689453","ACL":null,"DOI":"10.1177\/0014402918818047","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We describe a general procedure, based on Gerstenhaber-Schack complexes, for extending to quantized twistor spaces the Donaldson-Friedman gluing of twistor spaces via deformation theory of singular spaces. We consider in particular various possible quantizations of twistor spaces that leave the underlying spacetime manifold classical, including the geometric quantization of twistor spaces originally constructed by the second author, as well as some variants based on noncommutative geometry. We discuss specific aspects of the gluing construction for these different quantization procedures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":227335220,"openaccessinfo":{"externalids":{"MAG":"3113112760","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2012.02823"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Within the issue of transmission of signals with no constant envelope as Orthogonal Frequency Division Multiplexing (OFDM) for example, the Peak-to-Average Power Ratio (PAPR) reduction and the linearization are nowadays the two solutions proposed to deal the effects of the nonlinearities of the power amplifiers. In spite of their interdependence, these two solutions are separately studied and optimized. This can degrade seriously their common performance once stakes together because of opposite effects. In this paper, based on Rapp's memoryless amplifier, we demonstrate that predistortion increase the signal's PAPR and then proposed a joint combination scheme of \"clipping & filtering\" and polynomial predistortion. Computer simulations and analysis show that signal keeps a good level of linearity improvement measured with Modulation Error Ration (MER) while decreasing the predistortion's complexity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":2}},"corpusid":2852387,"openaccessinfo":{"externalids":{"MAG":"2145554626","ACL":null,"DOI":"10.1109\/URSIGASS.2011.6050516","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article arises from a systematic review of the International Baccalaureate (IB) Primary Years Programme (PYP). Four databases were consulted, and after the application of inclusion and exclusion criteria, 21 articles were selected and analysed in the following categories: year and author, country, type of research, participants, purpose and results. The results show a growth in PYP research in recent years, coming from several countries around the world, using mainly qualitative or mixed methodologies with small samples of teachers, students, administrators and families in IB schools. There is great variety in the purposes of the studies, the most representative being comparative analysis of the implementation of the programme, the use of a language for IB teaching other than that of the country in which the school is located, and the treatment of interculturality. These studies find differences in the ease of implementation of the programme depending on the context and geographical location of the schools, and also highlight the benefits of the programme for intercultural education and foreign language learning. Some tensions can be observed between the PYP curriculum and national policies, and also in the training and predisposition of teachers towards this particular methodology. More research is needed on the academic benefits of the PYP in comparison with other methodologies that are also working well at the curriculum level.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":260044164,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/14752409231188215","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The author presents a new design strategy for the artificial reproduction of ship-board-generated sounds for temporal marine simulators. An overview is furnished of previous analog and digital synthesis techniques. A coherent design rationale for a VLSI-based digital sound synthesizer prototype is discussed, together with a full description of the interface bus, which permits very fast communications with the main simulator computer. A flow chart of the sound synthesizer board and a circuit diagram of its VLSI realization are provided.<>","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":109692472,"openaccessinfo":{"externalids":{"MAG":"1690847637","ACL":null,"DOI":"10.1109\/CMPEUR.1989.93384","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A fusion of jungle, garage, hip-hop and Jamaican sound system culture, grime emerged from the housing estates of East London in the early 2000s. The genre has always had strong ties to gaming, from producers who cut their compositional teeth on Mario Paint (Nintendo R&D1, 1992) to MCs who incorporate videogame references into their lyrics, album titles and aliases. This article traces grime's relationship with gaming from the genre's inception to the present, focusing on two case studies: veteran London MC D Double E's 2010 track \"Street Fighter Riddim\" and Senegalese-Kuwaiti musician Fatima Al Qadiri's 2012 Desert Strike EP, a \"soundtrack\" to her experiences of the first Gulf War. Showing how players build videogames into their life stories and identities, these case studies affirm that gaming was never the exclusive preserve of \"nerdy\" white middle-class males while foregrounding the ludic dimensions of digital musicianship and the musical dimensions of digital play.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209451107,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Purpose: The purpose of this study is to evaluate the incidence of maternal cell contamination (MCC) in the first few milliliters of amniotic fluid withdrawn during amniocentesis. Methods: A prospective observational study was performed. The initial 2\u20133\u2009ml of amniotic fluid withdrawn during amniocentesis was divided into direct analysis (uncultured) and cultured samples. A matching maternal buccal swab was obtained for MCC testing. MCC was determined by short-tandem repeat analysis. The primary outcome was measurement of clinically significant contamination (MCC\u2009>5%). Secondary outcomes included the determination of risk factors associated with MCC\u2009>5%. Outcomes were assessed by fisher's exact, independent t-test, binary logistic regression, and ANOVA. Results: Direct analysis measured clinically significant contamination (MCC\u2009>\u20095%) in 26% of specimens, while any amount of MCC was present in 68% of specimens. Cultured specimens had MCC\u2009>\u20095% in 2%, and any amount of MCC in 24%. Only blood-tinged fluid was associated with an increased risk for MCC\u2009>\u20095%. Larger volumes of the discard sample were not associated with increased incidence of MCC greater than 5%. Conclusion: A significant amount of MCC is present with direct analysis of the initial few milliliters of amniotic fluid withdrawn and is not influenced by the volume of the discard sample. Our results suggest that the first few milliliters of amniotic fluid be removed and discarded when direct analysis is utilized for prenatal genetic testing.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":13764773,"openaccessinfo":{"externalids":{"MAG":"2538582721","ACL":null,"DOI":"10.1080\/14767058.2016.1240162","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This paper presents a pioneering effort to ascertain the suitability of hyperelastic modelling in simulating the stress\u2013strain response of oil palm shell reinforced rubber (ROPS) composites. ROPS composites with different oil palm shell contents (0%, 5%, 10% and 20% by volume) were cast in the laboratory for the experimental investigation. ROPS specimens with circular, square, hexagon, and octagon shapes (loading surface) were considered to evaluate the accuracy of finite element simulation considering the shape effect of composites. Strain-controlled (compressive) tests with \u03b5 \u2248 50% at 0.8 Hz frequency were conducted in the laboratory and the test data obtained was used as input to simulate material coefficients corresponding to the strain energy functions chosen. Five different strain energy functions were selected and utilized for the hyperelastic modelling in this study using finite element approach. The shape effect was then used to ascertain any variation in the simulation outcomes and to discuss the effect of shape on the behaviour of ROPS composites in comparison to existing literature. The numerical predictions using the Yeoh model (error \u2264 2.7% for circular shaped ROPS) were found to perform best in comparison with the experimental results, thus a more stable and suitable hyperelastic model to this end. The Marlow (error \u2264 4.6% for circular shaped ROPS) and Arruda Boyce (error \u2264 4.7% for circular shaped ROPS) models were amongst the next alternatives to perform better. Even with the other shapes considered in this study, Yeoh, followed by the Marlow function, were more appropriate models. The shape effect was then studied with particular emphasis on comparing and assessing them with that observed in the literature. To this end, adopting the Yeoh function in the finite element model is the ideal approach to estimate the stress\u2013strain response of ROPS composites.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":211047143,"openaccessinfo":{"externalids":{"MAG":"3003833058","ACL":null,"DOI":"10.3390\/polym12020314","PubMedCentral":"7077467","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-4360\/12\/2\/314\/pdf?version=1582983674","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Congenital dyserythropoietic anemias (CDAs) are displayed by ineffective erythropoiesis. The wide variety of phenotypes observed in CDA patients makes differential diagnosis difficult; identification of the genetic variants is crucial in clinical management. We report the fifth case of a patient with unclassified CDAs, after genetic study, with CDA type IV.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12805935,"openaccessinfo":{"externalids":{"MAG":"2580891787","ACL":null,"DOI":"10.1002\/ccr3.825","PubMedCentral":"5331261","ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1002\/ccr3.825","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"PURPOSE\nTo investigate the efficacy of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) in the detection of focal liver lesions with respect to dose, side effects, and pulse sequence.\n\n\nMATERIALS AND METHODS\nA randomized double-blinded trial was performed in 33 patients with focal solid liver lesions. A bolus of Gd-EOB-DTPA, a liver-specific contrast agent, was intravenously administered at three different doses (12.5, 25, and 50 mumol per kilogram of body weight). Magnetic resonance imaging with different T1-weighted techniques was performed 20 and 45 minutes after administration of Gd-EOB-DTPA. Changes in liver signal intensity, lesion-liver contrast-to-noise ration (C\/N), detectable liver lesions, side effects, and adverse events were evaluated.\n\n\nRESULTS\nGd-EOB-DTPA significantly (P < .05) increased liver signal intensity and lesion-liver C\/N within the dose range tested. Lesion detection was improved 20 and 45 minutes after administration of Gd-EOB-DTPA. A dose of 12.5 mumol was sufficient for the detection of focal liver lesions, and the breath-hold, T1-weighted, fast low-angle shot pulse sequence was the most useful. No significant changes in vital signs, clinical laboratory test results, and urinalysis were observed.\n\n\nCONCLUSION\nGd-EOB-DTPA is an efficient, diagnostically useful, and safe contrast agent.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":39672132,"openaccessinfo":{"externalids":{"MAG":"2058174138","ACL":null,"DOI":"10.1148\/RADIOLOGY.199.1.8633143","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The process of sensemaking involves foraging through and extracting information from large sets of documents, and it can be a cognitively intensive task. A recent approach, the Immersive Space to Think (IST), allows analysts to browse, read, mark up documents, and use immersive 3D space to organize and label collections of documents. In this study, we observed seventeen novice analysts perform a historical analysis task in order to understand how users utilize the features of IST to extract meaning from large text-based datasets. We found three different layout strategies they employed to create meaning with the documents we provided. We further found patterns of interaction and organization that can inform future improvements to the IST approach.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":234477052,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/VR50410.2021.00077","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We establish a relationship between the sheaf-theoretic $\\operatorname{SL}(2,\\mathbb{C})$ Floer cohomology $\\mathit{HP}(Y)$, as defined by Abouzaid and Manolescu, for $Y$ a surgery on a small knot in $S^3$, and the $\\operatorname{SL}(2,\\mathbb{C})$ Casson invariant, as defined by Curtis. We use this to compute $\\mathit{HP}$ for surgeries on the trefoil and the figure-eight knots. We also compute $\\mathit{HP}$ for surgeries on two non-small knots, the granny and square knots.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":231857475,"openaccessinfo":{"externalids":{"MAG":"3126346568","ACL":null,"DOI":"10.1307\/mmj\/20216036","PubMedCentral":null,"ArXiv":"2002.04103"},"license":null,"url":"https:\/\/arxiv.org\/pdf\/2002.04103","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nPublished studies of children's neurodevelopment after in utero exposure to cocaine have not separated intrauterine from postnatal environmental effects as cocaine-using mothers cluster in low socioeconomic classes and have other risk factors.\n\n\nMETHODS\nTo overcome this limitation, a study was done to assess physical and neurodevelopmental characteristics of 52 children: 26 were adopted by parents who sought counselling in the Motherisk Program at the University of Toronto for prenatal cocaine exposure, and 26 were controls matched for maternal intelligence quotient (IQ), socioeconomic status and gestational age.\n\n\nMAIN OUTCOME MEASURES\nHead circumference, McCarthy General Cognitive Index (GCI) score, language performance and temperament tests.\n\n\nRESULTS\nThe children in the study group had smaller head circumferences (34th versus 54th percentiles p = 0.009), lower McCarthy GCI scores (102.8 versus 114.2, p = 0.02), poorer receptive and expressive language performance on the Reynell test, and higher activity levels, less persistence and increased distractibility on temperament tests. On multivariate analysis, cocaine exposure was significantly (p = 0.001) associated with lower IQ and poorer language development independent of intrauterine growth retardation and other potential confounders.\n\n\nINTERPRETATION\nBy controlling for postnatal environmental factors, this adoption study documents intrauterine developmental risks associated with cocaine exposure. Follow-up into school years is warranted to evaluate the extent of these effects.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-30":1,"unknown":2}},"corpusid":22419914,"openaccessinfo":{"externalids":{"MAG":"2188894307","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It won't be pumping out Doogie Howsers by the dozen, but an Ontario university may soon be producing doctors a little less long in the tooth than the average medical graduate. Starting in 2012, a few gifted high school students may find themselves on a fast track to earning medical degrees in six years, rather than the usual eight, at Queen's University in Kingston. \n \nThe concept may be novel for Canada, but is fairly common in the United Kingdom, Australia and the United States, where it is called a BS\/MD (bachelor science\/doctor of medicine) program. One theory for offering such a program is the hope that a reserved spot in medical school and a quicker path to academic and career goals will attract the brightest students. \n \nApproval appears likely for the proposed Accelerated Pathway to Medical School program at Queen's. Only 10 students would be accepted into the program each year, and they will have to be more than just intelligent, according to Michael Kawaja, associate dean of life sciences and biochemistry at the university. They must be creative, altruistic, humanistic and curious. They must exhibit leadership, communication and critical-thinking skills. They must possess a history of extracurricular activities and community involvement. \"That's a long list, but it's absolutely critical to find that total package,\" he says. \n \nBut will finding 10 total packages be a problem? Apparently not. \n \n\"We think these 10 kids are out there,\" says Dr. Richard Reznick, dean of Queen's Faculty of Health Sciences. \"We know they're out there \u2014 in fact, there's probably hundreds of high school students who fit that description.\" \n \nAnother form of accelerated medical education involves compressing medical school into three years from four years by requiring students to attend class year round, thus reducing the overall time period required to obtain an MD to seven from eight years. That is the model adopted by the University of Calgary in Alberta, where the majority of medical school entrants have completed bachelor degrees. \n \n \n \n \n \n \n \nKnowing there is a spot waiting for them in medical school the first day they enter university brings peace of mind for some students. \n \n \nImage courtesy of \u00a9 2012 Thinkstock \n \n \nAlthough it's three years of med school rather than four, \"it's not three-quarters of the experience,\" says Dr. Bruce Wright, associate dean of undergraduate medical education at the University of Calgary. \"We go all year round.\" \n \nBy not taking summers off, the medical school is able to meet the accreditation standard of 130 total weeks of instruction, set by the Liaison Committee on Medical Education for Canadian and American medical schools. In fact, the school actually exceeds that number by two, offering 132 weeks of medical education. The program attracts serious students who don't mind the added intensity of a compressed schedule. \n \n\"One of the reasons we do it is because we believe we should start treating future doctors how they are going to be in terms of time commitment when they are in practice,\" says Wright. \"We treat them like professionals from the get-go.\" \n \nThe advantage to the health care system is that doctors, always in demand, enter the workforce sooner. The advantage for students is a reduction in time requirements and, just as importantly, in costs. \n \n\"This does allow those people who want an accelerated program to get on with it and save a year, and save some costs \u2014 certainly on living costs, like renting apartments,\" says Jocelyn Lockyer, senior associate dean of education for the faculty of medicine at the University of Calgary. \n \nAs for performance, Calgary students are competitive on showings in the medical council exams and the annual residency match, says Wright. In addition, faculty members at the medical school have analyzed how their students fare in the profession compared to those in traditional four-year medical programs, such as the one at the University of Alberta. A look at long-term outcomes, using data from the College of Physicians and Surgeons of Alberta Physician Achievement Review program, suggested \"at least equivalent performance for graduates of three- and four-year medical schools who practice in Alberta\" (Acad Med 2009;84:1342\u20137). \n \nA similar analysis, this one looking only at surgeons, indicated that \"if the duration of medical school programs could be adjusted, graduates could train in surgery and be ready for practice 1 year earlier without any detectable differences in competency on our assessment tool\" (Can J Surg 2012; 55:S163\u201370). \n \nStill, there are disadvantages to three-year medical school programs, acknowledges Lockyer, the primary author on both papers. The compressed schedule puts the medical school out of sync with the rest of the university, which can lead to logistical problems. And even though students take less time off, they still can't squeeze in as many weeks of education as most four-year programs. \n \n\"The difference is they haven't had as many clinical experiences,\" says Lockyer. \"The three or four extra months that a four-year-program has would provide more clinical time and a bit more time to mature and think about their career choices.\" \n \nIndeed, students in four-year programs do appear more prepared to make decisions about what type of careers they want to pursue in medicine, according to a comparison of the \"career maturity\" of medical students in accelerated and traditional programs (Career Dev Q 2007;56:171\u20136). The paper recommends that accelerated programs provide additional career guidance for their students. \n \n\"When you think about career decisions in general, people go through stages of development. It starts during early periods of awareness and exploration. As you get older, you learn more about the world of work and you start to understand more,\" says George Richard, one of the paper's authors and the director of careers in medicine at the Association of American Medical Colleges. \"The students in traditional programs have had more time and opportunities to explore and understand what the field of medicine is about. Students in accelerated programs don't have as much time and as many opportunities to do the kinds of activities needed during those stages of development.\" \n \nFor some high school students, though, having a spot waiting for them in medical school, rather than competing for one after completing a bachelor's degree, brings peace of mind. \"The anxiety is removed because they have a reserved seat, and typically they get to where they want to go faster,\" says Stephen Manuel, assistant dean of admissions at the University of Cincinnati College of Medicine in Ohio. \n \nThe University of Cincinnati follows the traditional \"4 plus 4\" model, but Manuel has been part of accelerated programs in the past, and says another advantage of reserving spots for high school students is the opportunity to provide extra resources for those who might struggle adjusting to university life. For example, a medical school attempting to attract more students from rural areas, in hopes they will return to those areas to practise medicine, could provide services to help those students succeed in their first year away from home. \n \nBut enrolment in an accelerated program may prove stressful for students who, after a couple of years of study, are no longer convinced they want to be physicians. After all, family and friends may already have visions of stethoscopes and white coats, while program administrators have certain expectations, having spent much time and effort to select the candidate from among a large pool and singled them out for an accelerated medical education. \n \n\"Students are having to make that selection of medicine as a career that much earlier, and the issue is that they sometimes feel they are on a path that they have to continue on,\" says Manuel. \"To step off that path can be hard for students to deal with.\"","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":7850318,"openaccessinfo":{"externalids":{"MAG":"2080343318","ACL":null,"DOI":"10.1503\/cmaj.109-4301","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/www.cmaj.ca\/content\/cmaj\/184\/16\/E845.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Diffraction from the second-order photorefractive grating written in KTa1-xNbxO3 (x=0.32) crystal with cubic phase has been observed for the first time. The behaviors of this diffraction have been investigated experimentally. Some qualitative explanations have been proposed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250842436,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0256-307X\/10\/4\/013","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INTRODUCTION\nThe Kidney Disease: Improving Global Outcomes (KDIGO) foundation promoted the establishment of the Chronic Kidney Disease (CKD) Prognosis Consortium to meta-analyze the association of estimated glomerular filtration rate (eGFR) and albuminuria with incidence of various outcomes in samples of general populations from all over the world.\n\n\nMETHODS\nVariables in meta-analysis included eGFR by the Modification of Diet in Renal Disease (MDRD) Study equation, the urinary albumin to creatinine ratio (uACR) as index of albuminuria, together with proteinuria at dipstick urinalysis and classical markers of cardiovascular risk. Overall, 105,872 participants had uACR measurements, and 1,128,310 participants had dipstick measurements.\n\n\nRESULTS\nThe association with mortality was continuous over the whole range of uACR\/proteinuria and J-shaped for eGFR which was associated with an excess risk for values <75 and \u2265120 ml\/min per 1.73 m\u00b2. Results were similar for the association of eGFR or uACR\/proteinuria with renal failure. The associations of eGFR and uACR\/proteinuria with death or renal failure were independent of each other. Findings were consistent across population samples from North America, Asia, Oceania and Europe, as well as in individuals with age <65 years and individuals with age \u226565 years.\n\n\nCONCLUSIONS\nData support the threshold of 60 ml\/min for CKD definition but suggest that eGFR in the range 60-74 ml\/min could represent the early stages of CKD. This first set of results of the CKD Prognosis Consortium represents an important step in the evidence-based definition of CKD. Conclusions should be reevaluated with eGFR calculation by equations less biased for normal-high eGFR.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24067727,"openaccessinfo":{"externalids":{"MAG":"1972862128","ACL":null,"DOI":"10.5301\/jn.5000045","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The present invention is the presence of a biocatalyst, a method and apparatus for producing aqueous acrylamide solution by hydrating acrylonitrile in an aqueous solution.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108916891,"openaccessinfo":{"externalids":{"MAG":"2925223965","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 103rd Annual Meeting 2012\u2010\u2010 Mar 31\u2010Apr 4, 2012; Chicago, IL\n\nTumor-suppressor genes on chromosome X can be inactivated by a single hit, any of point mutations, chromosomal loss, and aberrant DNA methylation. Among these mechanisms, aberrant DNA methylation can be present not only in tumor tissue but also in normal-appearing tissues. Levels of aberrant DNA methylation in non-cancerous tissues are known to correlate with cancer risk for gastric cancers and other cancers (epigenetic field defect). However, only a limited number of genes that functionally contribute to the field defect have been identified. To identify a tumor-suppressor gene on chromosome X that contributes to the formation of an epigenetic field defect, we here searched for genes on chromosome X whose expression was up-regulated by treatment of AGS gastric cancer cell line with a DNA demethylating agent, 5-aza-2\u2032-deoxycytidine (5-aza-dC). Among the 495 genes up-regulated at 4-fold or more by treatment with 5-aza-dC, 69 genes were located on chromosome X. Among the 69 genes, 11 genes had low expression (signal intensity 500) in a pool of gastric mucosae of three healthy volunteers. Among the 11 genes, FHL1 was frequently methylation-silenced in gastric and colon cancer cell lines, and in primary gastric (11\/58) and colon (5\/50) cancers. In HCT116 cells, knock-down of FHL1 accelerated cell growth (shRNA-1, 243 % of control cells at 120 hours, P < 0.001, and shRNA-2, 191%, P < 0.001) and sizes of xenografts in nude mice (shRNA-1, 2.7-fold larger tumors than that of control cells, P < 0.001). Also in HSC39 cells, knock-down of FHL1 significantly increased cell growth. Expression of exogenous FHL1 in a non-expressing AGS cell line significantly reduced its growth (72.2% of control cells, P < 0.05). A somatic mutation (G642T; Lys214Asn) was identified in one of 144 colon cancer specimens, and the mutant FHL1 was shown to lack a growth-suppressive effect. Among the healthy volunteers, FHL1 methylation was elevated only in H. pylori-positive individuals (0\/16 vs. 10\/16, P < 0.001). Since potent methylation induction by H. pylori can mask a difference in H. pylori-positive individuals, FHL1 methylation levels were compared between healthy volunteers and gastric cancer patients among the H. pylori-negative individuals, and FHL1 methylation levels were shown to be elevated only in gastric cancer patients (0\/16 vs. 5\/26, P = 0.06). These data showed that FHL1 is a methylation-silenced tumor-suppressor gene on chromosome X in gastrointestinal cancers, and that its silencing contributes to the formation of an epigenetic field for cancerization.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2169. doi:1538-7445.AM2012-2169","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":84146124,"openaccessinfo":{"externalids":{"MAG":"1996572424","ACL":null,"DOI":"10.1158\/1538-7445.AM2012-2169","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Projections of future demand for nuclear-powered electrical generating capacity indicate that a large amount of uranium will be needed by the year 2000. Uranium deposits of the type found in the Colorado Plateau region and in Tertiary basins in Wyoming have been the principal source of uranium in the United States, and potential resources in such deposits are large. Even so, they may not be fully adequate to supply all the uranium needed. For this reason, attention is focused here on a variant type of deposit that so far has not yielded much uranium, but that may have a sigtiificant potential because the deposits are widely distributed in a geologic setting that is extensive in western United States. The deposits, like the better known Colorado Plateau and Wyoming deposits, consist of uranium minerals interstitial in continental sandstone and conglomerate that also contain carbonized plant remains. The deposits are in lenticular beds within sequences of Tertiary volcanic rocks, mostly at or near the base of a sequence. The sedimentary lenses containing mineralized rock are irregular, probably because their form and distribution were controlled in part by underlying pre-volcanic topography and in part by drainage changes on an unstable volcanic terrane. If geologic ingenuity can discern the irregular pattern of the host lenses under a cover of volcanic rocks and establish the relation of deposits to the pattern, new uranium resources might be the reward.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-10":1,"unknown":2}},"corpusid":222289645,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Product portfolio management is crucial to product-oriented software companies' long-term success but is mostly overlooked by current software engineering research. This paper presents preliminary results from a multiple case study on the state-of-thepractice and improvement of product portfolio management processes in three small product-oriented software companies. Our findings suggest that implementing portfolio management as explained in the literature is based on assumptions about the product development process that do not hold in the context of small software product businesses. Based on the limitations of existing research this paper presents a number of questions to guide further work.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":213198657,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/icse19354.2012","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.soberit.hut.fi\/sems\/shared\/deliverables_public\/EDSER-6_jvahanii_44_review only.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This article analyzes the connections of the social sciences in Chile with the knowledge produced in central countries in comparison to those established within Chile and with other Latin American countries, paying particular attention to the connections regarding theory. It is based on content analysis of academic publications, and on social network analysis applied to a database of more than 20,000 bibliographical references generated for this research project from the universe of investigations published by Chilean social scientists over a period of seven years in the first decade of this century, in journals and books, both in Chile and abroad. The results show that, regarding international communications, there is a low level of connectivity with other Latin American countries, but that the communications among Chilean authors are relatively important and particularly those with a group of local theorists who occupy central positions in the network. This does not appear to be a pattern of cognitive dependence although it occurs within the context of a global science that is characterized by a remarkable inequality.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":220709979,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1177\/0011392114521374","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Embodied cognition and emotion: A new explorative tool Victor Kuperman McMaster University Amy Beth Warriner McMaster University Abstract: We present an experimental tool that tests the effect of emotionality (psychological valence, arousal and dominance) of a word meaning or a picture content on the approach-avoidance motivational systems. A participant is presented with a slider with a schematic human figure in the middle and a word\/picture at the top or bottom of the slider. The instruction is to use the computer mouse to move the figure as close to or as far from the stimulus as the person wishes: the distance of the figure from the stimulus, the duration and the number of mouse clicks serve as behavioral indices of the bodily state. By manipulating the figure (child or adult of the same\/opposite sex, animal, shape), and emotionality of the word\/picture, we were able to replicate both the effects of valence and arousal on approach-avoidance, as well as uncover gender and individual differences in perception of emotion.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2879537,"openaccessinfo":{"externalids":{"MAG":"2406844871","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sandia National Laboratories has funded the research and development of a new capability to interactively explore the effects of cyber exploits on the performance of physical protection systems. This informal, interim report of progress summarizes the project's basis and year one (of two) accomplishments. It includes descriptions of confirmed cyber exploits against a representative testbed protection system and details the development of an emulytics capability to support live, virtual, and constructive experiments. This work will support stakeholders to better engineer, operate, and maintain reliable protection systems.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":114893480,"openaccessinfo":{"externalids":{"MAG":"2411763493","ACL":null,"DOI":"10.2172\/1234817","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.osti.gov\/servlets\/purl\/1234817","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The role of the initial electronic configuration in the multiphoton ionisation of two-electron atoms is studied by considering three different wavefunctions to describe the ground state of helium. The theoretical treatment of the multiphoton process is an extension to a two-electron problem of the non-perturbative Keldysh model. Though the initial electronic charge distributions predicted by the chosen wavefunctions are largely similar, the ionisation rates provided by them are found to differ by orders of magnitude when the number of photons required to ionise increases. Accordingly, an accurate description of the initial electronic configuration in a process which is highly non-linear is found necessary. Besides, as a process involving a large number of photons may occur only in the presence of a sufficiently strong Coulomb field, it is argued that a multiphoton process may be used as a probe of the electronic correlation in atoms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250865640,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/0953-4075\/21\/21\/002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Reading a literary work might give us an idea of the situations of society in a particular time. In the sociology of literature, this phenomenon is referred as a mirror of an age. This means that a literary work does not simply describe the conditions of a society, but also values the tradition of a society. Taking Tan novel as its object, this study to see the description of Indonesia's condition, at the time when the novel was composed by Hendri Teja. Alan Swingewood and Diana Laurenson's idea which sees literary work is the reflection of the age are used as an approach to this study. The data which were taken from the novel were analized by relating them to the secondary data taken from articles discussing the situation of society depicted in the novel. The study concluded that the description in Tan novel does not only resemble Indonesian conditions but it also portrays values in the society, i.e. plurality in religion and social class and general agreement in decision making. The way the society value multiculturalism reflects the greatness of Indonesian people to accept the difference and their practicing of democratic system. In addition, this study also found out that this novel also criticize long running problem between the working class and the capital owner in Indonesian society.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":150006761,"openaccessinfo":{"externalids":{"MAG":"2907609353","ACL":null,"DOI":"10.21776\/UB.ALPHABET.2018.01.01.08","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Information and communication technology (ICT) is increasingly being used in the home environment, making it a very important and interesting research topic for communication scientists. Future developments will influence the way and the extent to which ICT will be used in the home environment and therefore the way people look for information, communicate, make use of entertainment services and carry out transactions. However, it is still very difficult to make meaningful and accurate forecasts with regard to the possible future use and acceptance of ICT in people's homes. Important reasons are, for example, that more and more market parties are involved in the development of innovative ICT products and services. This makes developments more complex and the outcomes more uncertain. Furthermore, consumers play an important role in the development of new ICT\u2010based information, communication, transaction and entertainment services. Since a precise prediction of the possible use of ICT in domestic environments in 2010 is hard to make, other methods of futures research must be used. Combining technological forecasting with scenario thinking is such a research method, whereon, technological forecasting shows the major trends in the specific technology domain, while scenarios cover the possible future worlds. By giving end\u2010users a central place in these scenarios, the diversity of the use and acceptance of innovative products and services is captured. Thus, the addition of scenarios to the technology trends gives insight into the possibilities (and impossibilities) of new ICT\u2010technologies and the way they may be used in the home environment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":153977898,"openaccessinfo":{"externalids":{"MAG":"1589882910","ACL":null,"DOI":"10.1108\/14636680310494717","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo assess parental reporting of diagnosis used in surveys as an indicator of pediatric asthma prevalence.\n\n\nMETHODS\nAnalysis of the Medical Expenditure Panel Survey, 1996 and 1997 (10 404 children aged from 0 to 17 years). All values are expressed as mean (SE).\n\n\nRESULTS\nAsthma medications were purchased for 2.5% (0.2%) of children. Parents of 45.4% (4.0%) of these children failed to report asthma, including 41.3 (10.5%) of those for whom maintenance medications were purchased. These findings remained unchanged when very young children were excluded from the sample. Controlling for insurance coverage, no racial, ethnic, or socioeconomic disparities in reported asthma were found; however, poor children were more likely to have maintenance medications purchased (odds ratio, 4.9; 95% confidence interval, 2.3-10.4).\n\n\nCONCLUSIONS\nSurveys of parental reports of asthma overlook many children with active disease. Dependence on parental reports may underestimate the prevalence of serious asthma among poor children. The parents in this study who fail to report asthma may represent a group that perceives their children's disease as less serious a problem despite active purchasing of medications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":907955,"openaccessinfo":{"externalids":{"MAG":"2171809003","ACL":null,"DOI":"10.1001\/ARCHPEDI.157.5.449","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We develop a state-of-the-art numerical algorithm for solving the relativistic viscous hydrodynamic \nequation, using a Riemann solver based on two-shock approximation. \nWe show validity of our hydrodynamics code from comparison with analytical solutions of \ntest problems. \nFurthermore we perform numerical hydrodynamic calculation with a realistic fluctuating initial condition of high-energy \nheavy-ion collisions at LHC produced by TRENTO. \nWe show time evolution of temperature distributions on $x-y$ and $x-\\eta$ planes with lattice QCD equation of state (EoS) and \ndiscuss the EoS dependence of it .","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":125099597,"openaccessinfo":{"externalids":{"MAG":"2804893391","ACL":null,"DOI":"10.22323\/1.294.0014","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/pos.sissa.it\/294\/014\/pdf","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"[1]\u00a0To investigate spatial variations of CH4 concentration, \u03b413CH4, and \u03b4D-CH4 over Alaska, aircraft observations were conducted during the summer of 2006. CH4 concentrations elevated above the background level were observed over areas with wetlands and wildfires, important sources of CH4. Several flights showed elevated CH4 values, with corresponding \u03b413CH4 and \u03b4D-CH4 signatures of \u221263.4\u2030 \u00b1 3.0\u2030 and \u2212424\u2030 \u00b1 79\u2030, respectively, which are based on the relationship between \u03b413CH4 (or \u03b4D-CH4) and CH4 concentration (single mixing relation), an indication of wetland source. It was also noted that both wetlands and wildfires influenced the CH4 concentrations observed over the wildfire area. Assuming certain emission ratios of CH4 to CO (ERCH4\/CO) for the wildfire and certain values of \u03b413CH4 and \u03b4D-CH4 for wetland CH4, we derived \u03b413CH4 and \u03b4D-CH4 of CH4 emitted from the wildfire to be \u221227.5\u2030 \u00b1 2.0\u2030 and \u2212285\u2030 \u00b1 111\u2030, respectively, which agreed relatively well with, but was slightly lower than, those obtained by previous studies at lower latitudes. To verify these estimates, bonfire experiments were conducted in the interior of Alaska using the same biomass material burned in the wildfire observed by the aircraft. The result showed that the previously reported ERCH4\/CO value was plausible and that \u03b413CH4 and \u03b4D-CH4 obtained by the bonfire experiments agreed with the estimates by the aircraft observations. We also found that \u03b413CH4 and \u03b4D-CH4 values became enriched with increasing combustion efficiency. By using the relationship between \u03b4D-CH4 for biomass burning and \u03b4D of precipitation, global average of \u03b4D-CH4 emitted from biomass burning was estimated to be \u2212204\u2030 \u00b1 11\u2030.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":128868948,"openaccessinfo":{"externalids":{"MAG":"1974645548","ACL":null,"DOI":"10.1029\/2010JD015545","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction: Laparoscopic appendectomy is the gold standard method of treatment of acute appendicitis. Closure of appendicular stump is the most important step to prevent complications. There are various methods to occlude the appendix. There is an insufficient analysis of the various methods to close the appendicular stump. The aim of this study was to analysis provide a treatment ranking of different options for securing the appendicular stump among endoloop, endostaplers, titanium clip, suture knots, Hem-o-Lok. \n \nMethods: Online electronic databases were searched to find observation studies, review articles, randomized controlled trials comparing various methods ligation of the appendix. The primary outcomes were cost, availability, biocompatible, safety, learning curve. \n \nConclusion: The application of Hem-o-Lok for occluding the appendix in laparoscopic appendectomy seems to be superior to other methods but the final decision on the method to be used will depend on the surgeon's experience and training with various techniques, the availability of equipment within the hospital, cost-effectiveness and the extent of appendix inflammation.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":212493021,"openaccessinfo":{"externalids":{"MAG":"3000742970","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The focus of the present study was to explore the effect of pedagogical grammar on the word guessing of intermediate EFL learners in reading. The participants of the present study were 30 learners at the intermediate level. They were selected based on their scores on language proficiency test. The researcher divided the learners of the present study into experimental and control groups. Then, the researcher gave the two groups a test of reading comprehension (as pretest). It consisted of an authentic text with some unfamiliar words. After administering the pretest, the treatment began. For the experimental group, the grammar was taught mainly based on the pedagogical grammar methodology. In contrast, control group was taught based on conventional methods of grammar instruction. After the instruction, the researcher gave a test of reading as posttest. In addition to this, learners answered a grammar test. After gathering the required data, they were analyzed using SPSS software (Paired and Independent Sample t -tests). The Pearson correlation was also used to find out the relationship between the learners' grammar knowledge and their ability to guess the word meanings in reading texts. The results indicated that the knowledge of pedagogical grammar had a significant effect on intermediate learners' word guessing in reading texts. Also, the correlation coefficient was found between knowledge of grammar and the ability to guess the words' meanings in reading texts.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":59584914,"openaccessinfo":{"externalids":{"MAG":"2766753106","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"New Zealand's native bush has been substantially reduced in extent by human actions. Valuable native bush fragments remain on private land. Protection of these fragments is required on multi-generational timescales appropriate to their succession periods.\u00a0\u00a0Social influence has been shown to predict human behaviour in a variety of behavioural domains and research settings. Social norms possess a self-reinforcing characteristic that may lead to the diffusion and embedding of behaviour and attitude change in society also on a multi-generational time-scale.\u00a0\u00a0The role of social influence in New Zealand landowners' decisions with respect to native trees on their land is examined for two populations. One population is a shared interest group (the 'Farm Forestry Association'); the other is the general population of rural landowners. Data is gathered using questionnaires based on the Theory of Planned Behaviour.\u00a0\u00a0Weak social influence is shown to be present for participants' intentions to increase or decrease native tree cover on their land. The strength of social influence is moderated by the frequency of social interaction. Contrary to the research hypothesis, the two groups do not differ in the norms they perceive nor the strength of social influence experienced. Suggestions are made for developing and applying the research methods in a small group setting.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":169283216,"openaccessinfo":{"externalids":{"MAG":"2783692071","ACL":null,"DOI":"10.26686\/wgtn.17065235","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/openaccess.wgtn.ac.nz\/articles\/thesis\/The_role_of_social_influence_in_New_Zealand_rural_landowners_land_use_decisions\/17065235\/1\/files\/31556057.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Memetic Algorithm is a population-based approach for heuristic search in optimization problems. It has shown that this mechanic performs better than traditional Genetic Algorithms for some problem. In order to apply in the multi-objective problem, the basic local search heuristics are combined with crossover operator in the sub-population in this research. This approach proposed is named as Sub-population with Memetic Algorithm, which is applied to deal with multi-objective Flowshop Scheduling Problems. Besides, the Artificial Chromosome with probability matrix will be introduced when the algorithm evolves to certain iteration for injecting to individual to search better combination of chromosomes, this mechanism will make faster convergent time for evolving. Compares with MOSA, the experiments result show that this algorithm possess fast convergence and average scatter of Pareto solutions simultaneously for solving multi-objective Flowshop Scheduling Problems in test instances.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":16864021,"openaccessinfo":{"externalids":{"MAG":"1998430385","ACL":null,"DOI":"10.1109\/ICCAE.2010.5451292","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nThis study aimed to establish the frequency of the frontal sinus (FS) aplasia, to compare metopic and nonmetopic series and thus to assess the relationship between the preservation of metopic suture and FS development.\n\n\nMATERIALS AND METHODS\nFSs were investigated in 230 dry skulls of adult males distributed into control (137) and metopic (93) series. They were visualized through industrial digital radiography.\n\n\nRESULTS\nIn the control series, the FS aplasia was observed in 12.41% of the skulls, and it was mostly unilateral (8.76%) than bilateral (3.65%). The left-sided aplasia (5.11%) slightly prevailed over the right-sided one (3.65%). In the metopic series, the aplasia was observed with a frequency of 19.35%, and the bilateral aplasia (7.53%) was rarer that the unilateral one (11.83%), while the right-sided aplasia was clearly predominant (9.68%) compared to the left-sided one (2.15%).\n\n\nDISCUSSION\nThe significant differences between both series showed a tendency for the persistence of metopic suture to be frequently related with FS underdevelopment in the vertical plate of the frontal bone, but in cases of pneumatization, it was preferentially on the left side. Taking into account that the cranial hypertension leads to suture diastasis and hinders development of the FS, it could be suggested that persistence of the metopic suture along with underdevelopment of the FS in nonsyndromic adults could be an expression of an elevated intracranial pressure during early development as an after-effect of certain condition.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3401528,"openaccessinfo":{"externalids":{"MAG":"2779976198","ACL":null,"DOI":"10.1002\/ajpa.23375","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we present CubicWare, a hierarchical design system which can estimate both timing and power consumption at the pre-layout stage. CubicWare consists of a floorplanner (CubicPlan), a delay calculator (CubicDelay), and a power estimator (CubicPower). CubicPlan provides accurate estimation of the interconnect parasitics, and CubicDelay calculates the delay including the effect of interconnects. Based on this delay, logic simulation is performed to verify the functionality and timing of the design. In the process, switching statistics on each gate is obtained. CubicPower reads the switching statistics and the power characteristics of gates to estimate the power consumption. The proposed parasitics estimation algorithm in CubicPlan can consider the coupling capacitances of the interconnects using the wiring congestion map. This approach provides a significantly improved correlation with the post-layout than the conventional statistical methods in terms of interconnect capacitances. CubicWare also supports the full functions of hierarchical manipulations including hierarchical delay calculation. The timing estimation of CubicWare at the pre-layout stage shows less than 10% error compared to the post-layout result. Experimental results of the dynamic power estimator at the gate level shows less than 10% error compared to the results of Powermill and the measured values of the IMS tester.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1,"unknown":3}},"corpusid":60789838,"openaccessinfo":{"externalids":{"MAG":"1951166569","ACL":null,"DOI":"10.1109\/ASIC.1999.806497","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We present in this paper the hard X-ray view of the pulsar wind nebula in G11.2\u22120.3 and its central pulsar powered pulsar J1811\u22121925 as seen by NuSTAR. We complement the data with Chandra for a more complete picture and confirm the existence of a hard, power-law component in the shell with photon index , which we attribute to synchrotron emission. Our imaging observations of the shell show a slightly smaller radius at higher energies, consistent with Chandra results, and we find shrinkage as a function of increased energy along the jet direction, indicating that the electron outflow in the PWN may be simpler than that seen in other young PWNe. Combining NuSTAR with INTEGRAL, we find that the pulsar spectrum can be fit by a power law with up to 300 keV without evidence of curvature.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":211572561,"openaccessinfo":{"externalids":{"MAG":"3106495731","ACL":null,"DOI":"10.3847\/1538-4357\/ab54ca","PubMedCentral":null,"ArXiv":"2002.12775"},"license":null,"url":"https:\/\/iopscience.iop.org\/article\/10.3847\/1538-4357\/ab54ca\/pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The latest progresses and achievements of deep-level diversity from six aspects has been reviewed, including its dimensions, mechanism, context factors, the interactions between the surface-level diversity and the deep-level diversity, the team faultlines and the cross-level study. Based on our review, we propose an integrated framework to present a number of future researches. We describe these directions to further exploration as follows: the antecedents of deep-level diversity, the cross-level study, team faultlines and its interactions with team outcomes, the relationship between deep-level diversity and team performance regarding to the social network backgrounds.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":131729049,"openaccessinfo":{"externalids":{"MAG":"2374706869","ACL":null,"DOI":"10.3724\/SP.J.1042.2014.00323","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present work, 5 aquaria were prepared, 3 series of experiments with one week intervals were carried out and total coliform bacteria counts were determined. Two each in aquarium of Tinca tinca L., 1758 and Alburnus escherichi Steindachner, 1987 were used. Dilutions from aquaria water were inoculated to VRBA (violet red bile agar). The petri dishes were incubated at 30\u00b110C and 35\u00b110C for 24 hours and the results evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":83227769,"openaccessinfo":{"externalids":{"MAG":"1586190303","ACL":null,"DOI":"10.17152\/gefd.85531","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective To find the best protocol from analyzing therapeutic effect and significance of different methods for primary liver carcinoma.Methods 121 patients with primary liver carcinoma treated in 1991.5~1998.5 were divided into 4 groups: Conservative treatment group (A): only treated by oral chemotherapy, Chinese traditional medicine and hepatic function support; Chemoembolization group (B): taking 1~7 times hepatic arterial chemoembolization (HACE); Hepatic resection group (C): taking hepatic segmentectomy or lobectomy; Hepatic resection+chemotherapy group (D): taking HACE or portal vein infusion (PVI) or hepatic artery infusion (HAI) before or after hepatic segmentectomy or lobectomy. 57 patients treated by HACE were also divided into 4 groups: One time HACE (B 1); Two times HACE(B 2); Over three times HACE(B 3); HACE+other methods(B 4).Results The median survival period of 37 cases with early stage primary liver carcinoma was 24.0 months. Their survival rates in 1 ,2 and 3 year was 67.6%, 55.9%, 44.1% respectively. The median survival period of 87 cases with advanced primary liver carcinoma was 2.5, 8.0, 7.0 and 10.0 months in group A, B, C, D respectively. Their survival rates in 1 , 2 and 3 year was 8.3%, 0, 0 in group A; 28.1%, 10.5%, 7.0% in group B; 25.0%, 12.5%, 0 in group C; 50.0%, 10.0%, 10.0% in group D respectively. The survival rates differed significantly between 4 groups. Their survival rates in 1 , 2 and 3 year of 57cases treated by HACE was: 0, 0, 0 in group B 1; 37.5%, 12.5% 6.3% in group B 2; 35.5%, 11.8%, 5.9% in group B 3; 28.6%, 14.3%, 14.3% in group B 4 respectively. The survival rates differed significantly between B 1 and B 2, B 3, B 4. The survival rate in 3 year differed significantly between B 4 and B 1, B 2, B 3. Conclusion Surgical resection combined with local hepatic chemotherapy or chemoembolization significantly improves the curative effect and life quality of the patient with primary liver carcinoma. The best protocol of HACE is 2~3 times and with other adjuvant therapy.\\;","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":75959501,"openaccessinfo":{"externalids":{"MAG":"2382601032","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Economists argue that the money supply positively impact on economic growth of nations. In Sri Lankan context this statement was not tested econometrically. Therefore, the aim of this study was to scrutinize the impact of money supply on Sri Lankan economy. To exam this objective, this study considered the time series data from the period of 1959 to 2013 and used two types of variables such as dependent and independent variables. Here, the gross domestic product was considered as dependent variable, and Money supply, Exchange rate, Exports earnings, Imports outflow, the Colombo consumer price index were deemed as independent variables. In the meantime, the multivariate econometric method was used to test the impacts of money supply on economic growth of Sri Lanka. According to the analytical results, the money supply has kept positive impact on the economic growth of Sri Lanka at 1% significant level. The R- squared of the estimated model was 92% which was indicated that the estimated model was desirable. Meanwhile, the Durbin Watson test statistic was 2.43 and also the Breusch\u2013Godfrey serial correlation LM test results was greater than 5%. Therefore, these statistics indicated that, the estimated model was not suffering from serial correlation.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":219355665,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Even though adnexal masses are detected during pregnancy ranging from 1 to 81 to 1 in 2.500 pregnancies, only 3% of these are malignant. A Krukenberg tumor is an ovarian metastasis of a gastric tumor and accounts for 1-2% of all ovarian tumors. A 29-year-old woman, gravida 3, para 2, was referred to our unit at 20 weeks' gestation because of epigastric pain for the last one week. Her abdominal ultrasound revealed a singleton pregnancy, with fetal measurements compatible with 20 weeks of gestation. A solid mass of 12.8 cm by 12 cm localized posterior to the uterus extending to both adnexial regions was also detected. Under general anesthesia, a midline abdominal incision was made. During abdominal inspection the gravid uterus was the size appropriate for the current gestational week. A 12 cm by 13 cm mass originating from the right ovary was excised. Then, a 17 cm by 18 cm mass originating from the left ovary was excised. The final pathology report confirmed positive washing cytology and a metastastic adenocarcinoma of both ovaries. Three weeks later, the woman had a gastroscopic biopsy and the pathology report was of an adenocarcinoma of the stomach. Unfortunately, the woman was lost to follow-up","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":74600014,"openaccessinfo":{"externalids":{"MAG":"2204795448","ACL":null,"DOI":"10.5472\/MMJ.2014.03283.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"5e\\'c l'a l polys tyrcnc supported coordination co mpound s o f thc types, PSCH2LM,DMF (M=C u, Zn, Cd, \/'v1 u0 2 and UOJ , I'SC II 2LFeCI,2DM !', I'SC H2LZr(O Il ), ,2DMF and I'SCH2LM, 3DMF(M=Mn, Co and Ni) ha ve been synt hes ized and characteri zed by cle illental anal yscs, \/R , rclkctance, ESR spcctral and magneti c susceptibilit y mcasurements, Thc Mn CII ), FcC III ), Co(l l), Ni(II ), Mo02(VI) and U02(VI) compound s havc an oc tahedral structurc, Cu(lI ) cO IllPound i, squarc planar, Zn( II) and CdC II ) compoll nds arc tct rahcdral. whi Ie Zr(1 V) compound is pe ntagonal \u00b7bipyraillidai. Thc compounds, PSCH,LM,3DMF(M=Mn, Co and Ni), PSCH,-LFeCi,2DMF and PSC Hr LCu-DMF are paraillagneti c, wh ile PSCH,LM,IJMF(M=Cd, Mo02, Zn and U02) and PSCH2LZr(OH)2,2DM F arc diaillagneti c. PSCH,LH, behavcs as tri cknt ,lte (ONO donor) dibasic in thcse cO lllpounds, The structures of thc co mpounds an; co mparable with the ce JlTcspolidilig coordinati on cO lllpoullds Df the lI oll ' ,ln l'hored Schill base,","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":97499382,"openaccessinfo":{"externalids":{"MAG":"2185151536","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We found 3 right and 2 left renal arteries with asymmetrical origins in a 61-year-old Korean male cadaver, whose cause of death was 'laryngeal carcinoma'. According to a previous classification, the first and second right renal arteries correspond to the early division and other renal arteries - to the extra renal arteries, except the first left renal artery as a typical renal artery. The third right renal artery ran anterior to the inferior vena cava to the inferior pole of the kidney. The first and second left renal arteries were associated with the inferior suprarenal artery and the testicular artery, respectively. The bilateral asymmetry in the number of renal arteries can be explained by the embryological development, degeneration and persistence of the renal artery in the process of ascending of kidneys.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12963664,"openaccessinfo":{"externalids":{"MAG":"2129394688","ACL":null,"DOI":"10.5603\/FM.2014.0078","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The phenomenon of short-term momentum in intriguing because it directly contradicts the notion that in an efficient market stock prices should lack memory.\u00a0 Three classes of possible explanation for momentum are (1) it is consistent with tenets of efficient markets after appropriate risk adjustment; (2) it is consistent with tenets of behavioral finance because of investors' cognitive biases; and (3) it is consistent with structurally-based positive feedback loops.\u00a0 The presence of extreme bubbles provides evidence against the first explanation.\u00a0 The fact that prices are effectively set by institutional investors who are aware of the cognitive biases in question and have a financial incentive to avoid them provides evidence against the second.\u00a0 Structurally-based explanations include the short-term incentives of institutional money managers and the impact of indexing.\u00a0\u00a0 We believe that considering structural factors affecting the behavior of stock prices provides an additional perspective, to be used in combination with behavioral finance and market efficiency.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":230641146,"openaccessinfo":{"externalids":{"MAG":"3111214910","ACL":null,"DOI":"10.14738\/abr.811.9312","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT For several decades, Troglotayosicus Louren\u00e7o, 1981, remained an enigmatic, monotypic scorpion genus believed to be troglobitic. The discovery and description in recent years of several endogean species of the genus, inhabiting the leaf litter of tropical rainforests in Colombia and Ecuador, advanced knowledge about these scorpions. The known distribution of Troglotayosicus was considerably expanded along the Andes, and it was demonstrated that, despite the absence of median ocelli, the genus is composed primarily of species that inhabit leaf litter. In the present study, Troglotayosicus ballvei, sp. nov., is described from Sacha Huagra Lodge, adjacent to Archidona Municipality, in Napo Province, Ecuador, raising the number of Troglotayosicus species to six, three each in Colombia and Ecuador. An updated map of the known distribution of the genus is presented.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1,"unknown":3}},"corpusid":241568681,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1206\/3981.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.biodiversitylibrary.org\/itempdf\/303546","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper describes the successful development by Esso Australia Ltd (Operator) and BHP Petroleum Pty Ltd of the Snapper field which is located in the Gippsland Basin beneath the waters of Bass Strait off south-eastern Australia. Discussion is focussed on the development of a thin, ''pancake'' type oil column of 4 to 8 metres thickness which underlies the Snapper N-1 gas reservoir. The gas reservoir, which has a maximum gross thickness of 208 metres, comprises very high quality sandstones with interbedded shales, siltstones and coals. A 27 conductor production platform has been installed in 55 metres of water with facilities for concurrent production of gas and oil. The timing of the development has permitted successful development of the thin oil column before major withdrawal of gas takes place. Development of the oil zone was complicated by the presence of interbedded non-net sections which, combined with the varying thickness of the oil column provided significant well targeting challenges. Several high angle wells were required for oil production which presented drilling and logging problems. However, 16 of the 21 wells drilled succeeded in intersecting oil columns suitable for production. Performance of the oil wells has been very encouraging, but also variable withmore\u00a0\u00bb a wide range of producing GOR's, water cuts and wellhead pressures. Thin oil columns of 2 to 15 metres overlying water and underlying a large gas cap are common within the Gippsland Basin and elsewhere. Snapper, the first development of one of these oil zones in the Gippsland Basin, has provided valuable and encouraging experience in performance of the wells, completions and surface equipment. This will assist economic assessment and facilities design for other with thin oil column development prospects.\u00ab\u00a0less","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-26":1,"2024-30":1}},"corpusid":129789860,"openaccessinfo":{"externalids":{"MAG":"2009398766","ACL":null,"DOI":"10.2118\/12408-MS","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chimney, which form the last component of a system using a flue gas such as boiler, play a vital role in maintaining efficiency, draft, etc, of a system and also in minimizing the atmospheric pollution. Steel chimneys are also known as steel stacks. The steel chimneys are made of steel plates and supported on foundation. The steel chimneys are used to escape and disperse the flue gases to such a height that the gases do not contaminate surrounding. In this thesis, chimney will be designed considering dead load and wind load. The Bureau of Indian Standards (BIS) design codes procedures will be used for the design of the chimney. The chimney was considered as a cantilever beam with annular cross section. 3D model of the chimney is done in Pro\/Engineer and coupled field analysis is done on the chimney in ANSYS. A simplified model of chimneys with various thicknesses like 10mm, 12mm, 14mm, and 16mm were modeled.\u00a0 atmosphere.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-30":1,"unknown":2}},"corpusid":134333579,"openaccessinfo":{"externalids":{"MAG":"2906593826","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Gravity is the foundation of the current physical paradigm. Due to that gravity is strongly linked to the curvature of space-time, we research that it lacks of a valid physical concept of space-time, nevertheless that from the science philosophy, via substantivalism, it has tried respond. We found that is due to that the gnoseological process applied from the general relativity, necessarily us leads to metaphysic because ontologically space-time is a metaphysical entity. Thus, we arrive to the super substantivalism that from metaphysics gives an answer on space-time rigorously exact with the vision of Einstein on physics. The result is that matter is nothing since all is space-time, i.e. geometry, therefore is a imperative of the physical science break the current paradigm.\u200e","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":13013015,"openaccessinfo":{"externalids":{"MAG":"2208561642","ACL":null,"DOI":"10.14331\/IJFPS.2013.330058","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper describes mathematical models of the torsional geared driving system for the indexing path and the mill driving path in a mill turret. The eigenvalue analysis for the models is conducted both with and without the gear contact stiffnesses. The natural frequency leads to the effect of gear contact stiffnesses on the vibration of torsional geared systems in a mill turret. It is necessary to analyze eigenvalues of the complex geared torsional system in order to prevent the unexpected vibrations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":108847520,"openaccessinfo":{"externalids":{"MAG":"1512829210","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The general method currently used to analyze radiocarbon data (y) is conditional on the standard deviation (\u03c3), reported by 14C laboratories, which reflects the uncertainty in the dating process. This uncertainty is measured through a series of empirical as well as theoretical considerations about the dating process, chemical preprocessing, etc. Nevertheless, \u03c3 is assumed as known in the statistical model for 14C data used since the dawn of the discipline. This paper proposes a method for the analysis of 14C data where the associated variance is taken as the product of an unknown constant \u03b1 with the sum of the variance reported by the laboratory \u03c32 and the variance of the calibration curve \u03c32(\u03b8) (that is, an unknown error multiplier). Using this approach, assuming that the 14C determination y arises from a Normal population and that, a priori, \u03b1 has an inverse gamma distribution InvGa(a, b), the resulting dating model is a t distribution with 2a degrees of freedom. The introduction of parameters a and b allows a robust analysis in the presence of atypical data and at the same time incorporates the uncertainty associated with the intra- and interlaboratory error assessment processes. Comparisons with the common Normal model show that the proposed t model produces smoother posterior distributions and seem to be far more robust to atypical data, presenting a simpler alternative to the standard 14C outlier analysis. Moreover, this new model might be a step forward in understanding and explaining the otherwise elusive scatter in 14C data seen in interlaboratory studies.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1}},"corpusid":58914159,"openaccessinfo":{"externalids":{"MAG":"2205675661","ACL":null,"DOI":"10.1017\/S003382220003410X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the application of controller synthesis for hybrid systems to aerodynamic envelope protection and safe switching between flight modes. Each flight mode, which describes a configuration of the dynamic equations describing the motion of the aircraft, is treated as a discrete state with associated continuous, nonlinear dynamics and the safe subset of the state space (that which ensures aerodynamic envelope protection) is calculated for each discrete state. The methodology is applied to a longitudinal axis model of a CTOL aircraft.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":110218030,"openaccessinfo":{"externalids":{"MAG":"2187863801","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This study aims to examine the views of Imam Al-Kasaei, which were mentioned specifically in the book \"Objectivity in Issues of disagreement between the Basrian and the Kufists Grammarians by Al-Anbari\" despite his other grammatical views that are dispersed in linguistic books. The choice of his views, which were mentioned in this book is due to the fact that they were discussed and that Al-Anbari made them more objective, by increasing the area of evidence, proofs, and arguments on each issue, whether he refuted a view or supported another. This was concluded after investigating the grammatical issues presented in the book under study, and finding that they were thirteen issues, which I mentioned and presented the views related to each. It was found that these grammatical views have constituted a rich material in the linguistic domain, as the researcher revealed that there are many issues in which Kasaei' had a say or opinion, whether corresponding to Al-Kufa school , to which he belongs, or Al-Basra school, or if he has an opinion of his own . The study followed the descriptive and analytical approach in addressing Kasaei's grammatical views, and in some cases resorted to the normative approach. The study reached a number of results, the most prominent of which was that Al-Kasaei had his own grammatical views that differ from those of Basrian and the Kufists Grammarians, and this confirms that he did not strictly hold on to a specific view.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":260890190,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"1. A new quantitative method of measuring phagocytosis of solid particles is described. 2. A method of calculating the chances of collision between leucocytes and quartz particles of different sizes is developed. 3. The speed with which three suspensions of different sized quartz particles should be ingested by leucocytes is predicted from the calculated chances of collision, and the prediction is verified experimentally. 4. The formula for the chances of collision is also verified by varying the speed of rotation of the tubes in which the phagocytic mixtures are incubated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85000495,"openaccessinfo":{"externalids":{"MAG":"2068793428","ACL":null,"DOI":"10.1085\/JGP.3.4.439","PubMedCentral":"2140473","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT This paper presents new bathymetric data acquired around Linosa Island, in the Pelagie Archipelago, revealing the submarine extension of the volcanic edifice, more wide and complex than previously known. The seafloor of Linosa, from the coastal area to about 1000\u2005m depth, was mapped with multibeam systems during the 'Linosa 2016' and 'BioGeoLin 2017' surveys. A bathymetric map of the surveyed area (about 298\u2005km2) was drawn at the original 1:30,000 scale. Overall, the submarine portions of Linosa extend on a total area of about 159\u2005km2 and are preferentially developed in a NW-SE direction, in agreement with the regional main tectonic trend in the area. The new bathymetric data allow to recognize different sectors in the submarine extension of the volcanic edifice where constructional (volcanic) activity alternates with erosive-depositional processes affecting the submarine flanks of the island.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":202186733,"openaccessinfo":{"externalids":{"MAG":"2967962716","ACL":null,"DOI":"10.1080\/17445647.2019.1642807","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17445647.2019.1642807?needAccess=true","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We report on the preparation and investigation of epitaxial thin films of the magnetic shape memory alloy Ni2MnGa. For samples close to the stoichiometric composition we find that the phase transformation temperature is affected by the crystallographic orientation. Changes in the crystal structure due to the transformation are observed using temperature-dependent X-ray diffraction. Films with higher manganese content are in the martensitic state at room temperature. Those samples on Al2O3(11-20) reveal the 7-layered orthorhombic structure that allows strains up to 10 %. To avoid blocking of magnetostrictive effects by the substrate, free-standing films are prepared using water-soluble NaCl(100) single crystals as substrate.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":138323414,"openaccessinfo":{"externalids":{"MAG":"2241951620","ACL":null,"DOI":"10.4028\/www.scientific.net\/MSF.635.155","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors propose an alternative conceptualization to the Strack, Werth and Deutsch (2006) model. Their conceptualization considers how the forecasting of emotional outcomes linked to controlling or failing to control impulses impacts self-regulatory behavior. A set of future research questions is identified based on this conceptualization. The proposed model differs from that by Strack et al. (2006) by its focus on (a) affect, (b) impulse control (versus buying) and (c) deliberative processing linked to impulse control (or lack thereof).","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":8257405,"openaccessinfo":{"externalids":{"MAG":"2165224980","ACL":null,"DOI":"10.1207\/S15327663JCP1603_4","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Incomplete longitudinal data are common in lifecourse epidemiology and may induce bias leading to incorrect inference. Multiple imputation (MI) is increasingly preferred for handling missing data, but few studies explore MI method performance and feasibility in real data settings. We compared three MI methods using real data under nine missing data scenarios, representing combinations of 10%, 20%, and 30% missingness and missing completely at random, at random, and not at random. Using data from Health and Retirement Study (HRS) participants, we introduced record-level missingness to a sample of participants with complete data on depressive symptoms (1998-2008), mortality (2008-2018), and relevant covariates. We then imputed missing data using three MI methods (normal linear regression, predictive mean matching, variable-tailored specification), and fit Cox proportional hazards models to estimate effects of four operationalizations of longitudinal depressive symptoms on mortality. We compared bias in hazard ratios, root mean square error (RMSE), and computation time for each method. Bias was similar across MI methods and results were consistent across operationalizations of the longitudinal exposure variable. However, our results suggest predictive mean matching may be an appealing strategy for imputing lifecourse exposure data given consistently low RMSE, competitive computation times, and few implementation challenges.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":259209634,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/aje\/kwad139","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of the research was to identify the behavioral patterns employed by caregivers when breaking bad news, and their affect on the patient. These issues were examined from three points of view: patients, doctors, and nurses. A total of 152 interviewees participated in the research: 51 patients, 51 nurses, and 50 doctors. They completed a constructed questionnaire that included 35 items developed for the research. Support patterns identified as effective were: allowing for the expression of emotions, empathic silence, support through touch, and the use of participatory, commendation, and encouragement statements. The research findings point to the crucial need for the involvement of a family-member and a nurse in the process, and providing written information for the receiver of the news. Significant differences (p < 0.05) between patients and caregivers were found in the type of information given, the timing and quantity, as well as in the support and communication patterns. The principal emotions caregivers experienced were identification and helplessness, and most of them were not trained in this field. The research findings could bridge the gap between what patients want and what caregivers actually do, and would be beneficial in designing guidelines for breaking bad news, as well as formulating a workshop program for furthering the team skills.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23708899,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Large-scale energy storage has recently been discussed as part of the future of the smart grid because of the many opportunities for improvement in the reliability and quality of the electric grid that can stem from their use. Information exchange from utility to consumer and vice versa makes it possible to send real-time signals regarding electricity prices and consumption. This enables many applications such as arbitrage, electric reserves, and load following to be served immediately by energy storage systems that are on the grid. For this reason, large-scale energy storage technologies must be implemented that have the ability to serve these applications. This paper examines three energy storage technologies that appear to be well suited for large-scale implementation: sodium-sulfur, vanadium-redox flow batteries, and lithium-ion batteries. These technologies were examined along with many other current technologies and chosen due to the potential to operate at grid-scales. Also, several of their potential applications are discussed.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2014-10":1,"2015-18":1}},"corpusid":31862413,"openaccessinfo":{"externalids":{"MAG":"2037076204","ACL":null,"DOI":"10.1109\/ISGT.2012.6175626","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nIndividuals with Down's syndrome (DS) have an auditory short-term memory span disproportionately shorter than the non-verbal mental age (MA). This study evaluated the Baddeley model's claim that verbal short-term memory deficits might arise from slower speaking rates (and thus less material rehearsed in a 2 s passive store) by using the sentence memory subtest of the Stanford-Binet. Previous work had shown digit span recall speaking rate to be comparable to the examiner's slow rate (one syllable per second) for both DS and language-matched participants.\n\n\nMETHOD\nThirty individuals with DS were compared to two control groups [non-verbal MA-matched and mean length of utterance (MLU)-matched] on the sentence span and speaking rate for the longest verbatim recalled sentence. Sentence stimuli were presented at a normal speaking rate.\n\n\nRESULTS\nThe DS group had shorter sentence memory span than the MA-matched group and a faster, rather than slower, speaking rate (syllables per second) than the MLU-matched controls.\n\n\nCONCLUSIONS\nLanguage production level accounted for a substantial portion of the variance in the sentence memory span in the DS group. Thus, language production skill, rather than speaking rate, predicts variability in verbal memory span.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37322683,"openaccessinfo":{"externalids":{"MAG":"2006151704","ACL":null,"DOI":"10.1111\/J.1365-2788.2004.00526.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The incidence of introgression during the diversification process and the timespan following divergence when introgression is possible are poorly understood in the neotropics where high species richness could provide extensive opportunities for genetic exchange. We used thousands of genome\u2010wide SNPs to infer phylogenetic relationships, calculate ages of splitting, and to estimate the timing of introgression in a widespread avian neotropical genus of woodcreepers. Five distinct introgression events were reconstructed involving taxa classified both as subspecies and species including lineages descending from the basal\u2013most split, dated to 7.3 million years ago. Introgression occurred between just a few hundred thousand to about 2.5 million years following divergence, suggesting substantial portions of the genome are capable of introgressing across taxa boundaries during a protracted time window of a few million years following divergence. Despite this protracted time window, we found that the proportion of the genome introgressing (6\u201311%) declines with the time of introgression following divergence, suggesting that the genome becomes progressively more immune to introgression as reproductive isolation increases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":209490687,"openaccessinfo":{"externalids":{"MAG":"2997539661","ACL":null,"DOI":"10.1111\/evo.13902","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/helda.helsinki.fi\/bitstream\/10138\/323657\/1\/Pulido_Santacruz_et_al_2020.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The modification of carbon-based nanomaterials with metals is widely studied due to its unique properties. Here, the modification of carbon nanomaterial with iron oxide has been successfully carried out. This modification was achieved using arc discharge in 50% ethanol liquid media. The anode used in the arc discharge was prepared from a mixture of carbon and iron oxide that was synthesized in electrolysis and was then calcined at 250\u00b0C with silicon binder with a mass ratio of 3:1:1, and the cathode used was graphite rod. Both electrodes were set in the nearest gap that could provide an arc during arc-discharging, leading to carbon-based nanoparticle formation. The diffractogram pattern of the X-ray diffraction of the fabricated nanoparticles confirmed the typical peak of carbon, iron oxide and iron. The magnetization value of the result analysis of the vibrating sample magnetometer was 9.9 emu\/g. The bandgap energy measurement using diffuse reflectance ultra violet was estimated to be 2.18 eV. Using the transmission electron microscopy, the structure of the nanomaterial produced was observed as carbon-encapsulated iron compound nanoparticles.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":100190380,"openaccessinfo":{"externalids":{"MAG":"2592333231","ACL":null,"DOI":"10.1088\/1757-899X\/176\/1\/012046","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Since the turn of the 21st century the term \"film \nmusicology\" has gradually come into use in \nAnglophone scholarship, though apparently \nwithout there being any published definition of its \ndisciplinary scope and methodology in relationship to \nmusicology and film studies, respectively. For example \nin reviewing the 2004 critical study Hollywood Theory, \nNon-Hollywood Practice by Annette Davison, Leslie \nAndersen comments that \"Davison describes [her] \nresearch early on as 'film musicology' (p. 1) without \na definition as to what this is. Is 'film musicology' \nthe musicology of film or the study of film music? \nDavison assumes that the reader understands what \nthis term means without documenting its origin.\" A \nclue can be found on the dust jacket of Davison's book \nthat quotes praise for the book from Robynn Stilwell: \n\"Annette Davison offers a second-generation approach \nto film musicology that stands in relationship to the \nfirst generation (Gorbman, Kalinak, et al) much as \nher subject stands to Hollywood cinema\u2014building \non, reacting against, making us think about the most \nbasic issues with new critical facilities.\" Inasmuch \nas neither Gorbman nor Kalinak are musicologists, \nbut are film scholars by virtue of academic training \nand professional discipline, and the et alia to whom \nStilwell alludes are disciplinarily anonymous, how did \nfilm musicology come to be constituted as a field of \nscholarly inquiry, if not by musicologists?","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":170487506,"openaccessinfo":{"externalids":{"MAG":"1994852568","ACL":null,"DOI":"10.1558\/JFM.V2I2-4.99","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract : Polymer-matrix composite material and structural adhesive repair and manufacturing have significant environmental costs. These costs have recently been documented based on current and anticipated future Department of Defense (DoD) use of these materials. The principal issues for reducing the environmental impact and its associated cost are: (1) reduction in hazardous waste by eliminating shelf-life limitations, (2) reduction in nitrogen oxides (NO(x)) by replacing global heating of the part with localized heating, (3) reduction in volatile organic compound (VOC) emissions by accelerated curing and containment, and (4) reduction in hazardous waste by minimizing production debris through processing step management Induction-based adhesive curing is a potential replacement for current repair and manufacturing methods to resolve the principal issues. The current work establishes that induction heating using conductive mesh susceptors can be used to rapidly cure thermosetting adhesives under a VOC-reducing vacuum condition. It is also established that the presence of these susceptor materials, although not optimized, does not adversely affect the mechanical performance of the bondline when considering the low scatter in lap shear strength. The feasibility of induction-based repair using metallic screen susceptors and the applicability of induction heating to multilayer single-step bonding wherein heat generation is limited to localized bondline regions allowing optimization of repair processes are demonstrated.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210335877,"openaccessinfo":{"externalids":{"MAG":"220415498","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Vesicles exposed to the human circulatory system experience a wide range of flows and Reynolds numbers. Previous investigations of vesicles in fluid flow have focused on the Stokes flow regime. In this work the influence of inertia on the dynamics of a vesicle in a shearing flow is investigated using a novel level-set computational method in two dimensions. A detailed analysis of the behaviour of a single vesicle at finite Reynolds number is presented. At low Reynolds numbers the results recover vesicle behaviour previously observed for Stokes flow. At moderate Reynolds numbers the classical tumbling behaviour of highly viscous vesicles is no longer observed. Instead, the vesicle is observed to tank-tread, with an equilibrium angle dependent on the Reynolds number and the reduced area of the vesicle. It is shown that a vesicle with an inner\/outer fluid viscosity ratio as high as 200 will not tumble if the Reynolds number is as low as 10. A new damped tank-treading behaviour, where the vesicle will briefly oscillate about the equilibrium inclination angle, is also observed. This behaviour is explained by an investigation on the torque acting on a vesicle in shear flow. Scaling laws for vesicles in inertial flows have also been determined. It is observed that quantities such as vesicle tumbling period follow square-root scaling with respect to the Reynolds number. Finally, the maximum tension as a function of the Reynolds number is also determined. It is observed that, as the Reynolds number increases, the maximum tension on the vesicle membrane also increases. This could play a role in the creation of stable pores in vesicle membranes or for the premature destruction of vesicles exposed to the human circulatory system.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":6004329,"openaccessinfo":{"externalids":{"MAG":"2322862996","ACL":null,"DOI":"10.1017\/jfm.2012.380","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Social semiotic approaches to spatial discourse analysis are employed to analyse the predefined arrangements of spaces and semiotic resources in three-dimensional spaces. These spaces and resources are recognized as spatial-texts that construct a discourse which communicates predefined meanings and ideologies. Aiming to advance the growing interest in spatial semiotics in different socio-cultural contexts, this study scrutinizes the spatial semiotic resources in the Martyr's Memorial and site in Amman, the Capital city of Jordan. The analysis is constructed through an approach of locative and reflective observation of the researcher's, and the visitors', experience with the different semiotic resources in the Memorial site. Then, these resources are interpreted on the basis of social semiotic approaches of spatial-discourse analysis. The study demonstrates that the Martyr's Memorial and its site encompass manifold semiotic resources which make a series of spatial-texts which are organized and arranged along a predefined narrative path. These spatial-texts make a coherent discourse that communicates and unfold well-established meanings and ideologies about the Arabic, and Islamic, conception of martyrdom, the role of the Jordanian Armed Forces, and the legacy of the Hashemite ruling dynasty. Such meanings and ideologies are reproduced on the basis of social, religious, and historical backgrounds.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":248454739,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.5296\/ijl.v14i2.19743","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.macrothink.org\/journal\/index.php\/ijl\/article\/download\/19743\/15341","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"While the slope of the dust attenuation curve (\u03b4) is found to correlate with effective dust attenuation (AV) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape this relation. We examine the degeneracy effects by fitting SEDs of a sample of local star-forming galaxies (SFGs) selected from the Galaxy And Mass Assembly survey, in conjunction with mock galaxy SEDs of known attenuation parameters. A well-designed declining starburst star formation history is adopted to generate model SED templates with intrinsic UV slope (\u03b20) spanning over a reasonably wide range. The best-fitting \u03b20 for our sample SFGs shows a wide coverage, dramatically differing from the limited range of \u03b20 < \u22122.2 for a starburst of constant star formation. Our results show that strong degeneracies between \u03b20, \u03b4, and AV in the SED fitting induce systematic biases leading to a false AV\u2013\u03b4 correlation. Our simulation tests reveal that this relationship can be well reproduced even when a flat AV\u2013\u03b4 relation is taken to build the input model galaxy SEDs. The variations in best-fitting \u03b4 are dominated by the fitting errors. We show that assuming a starburst with constant star formation in SED fitting will result in a steeper attenuation curve, smaller degeneracy errors, and a stronger AV\u2013\u03b4 relation. Our findings confirm that the AV\u2013\u03b4 relation obtained through SED fitting is likely driven by the systematic biases induced by the fitting degeneracies between \u03b20, \u03b4, and AV.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":245986420,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1093\/mnras\/stac132","PubMedCentral":null,"ArXiv":"2201.05467"},"license":null,"url":"https:\/\/purehost.bath.ac.uk\/ws\/files\/230145639\/Qin2022_arXiv.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Design factors to consider when the oil has a high viscosity and the stripper is a packed column using air to strip the soluble sulfur dioxide (SO 2 ) contained in an acid treated oil","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":113914983,"openaccessinfo":{"externalids":{"MAG":"2525457597","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The need for developing an exact theory of surface scattering, formulated in terms of explicitly known, universal functions is discussed, and numerical examples of such a theory are given.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":62097391,"openaccessinfo":{"externalids":{"MAG":"2183866360","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Accurate modeling of temporal changes plays important role in several applications in dynamic imaging such as list mode data acquisition, kinetic modeling, deconvolution of dynamic studies, or factor analysis. We present an algorithm that uses B-splines and allows modeling of any time curve. During the optimization the CAT B-spline adaptively reconfigures to model the temporal curve. Both, positions and values of intensity for the control points, are optimized. Physiological constraints put on the CAT B-spline model were used. Optimization was performed by minimization of the least squares objective function using the simulated annealing method with an adaptive temperature control. Computer simulations were performed to test the algorithm. Gaussian curves with different widths were simulated and CAT B-splines were fitted to those curves. Noiseless and noisy data were simulated. As an example of a CAT B-spline application we performed computer simulation of the deconvolution of the input function and transfer function. The results from CAT B-spline deconvolution were compared to standard algebraic SVD method. We found good performance of our algorithm in modeling of Gaussian dynamic curves. The deconvolution based on CAT B-splines performed well compared to the SVD yielding similar values of bias. However, the results from CAT B-spline method were less prone to a selection of regularization parameter which was a number of control points for CAT B-splines. CAT B-splines may be very useful in dynamic imaging.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-48":1}},"corpusid":21633577,"openaccessinfo":{"externalids":{"MAG":"2163426591","ACL":null,"DOI":"10.1109\/NSSMIC.2003.1352444","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The clinical experience of professor WANG Yin in the treatment of primary ovarian insufficiency are summarized. Regarding acupoints selection, the sancai, named \"heaven-earth-human being\" method is adopted, focusing on the regulation of the middle jiao and shen (mind\/spirit). Regarding needling technique, the elongated needle is used in preference. Besides, the bloodletting and cupping method with filiform-fire needle are innovated to achieve both the reinforcing and the reducing purposes as well as to eliminate stasis. The periodic therapy is applied to comply with the changes in the physiological cycle of gynecology. Acupuncture, Chinese herbal medicine, or the combination of them is selected in consideration of the concrete individual cases of primary ovarian insufficiency.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":233427265,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.13703\/j.0255-2930.20200211-0003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\u202aThe concept of innovation network (IN) is a well-established one that has been the object of an extensive canon of literature. Our subject in this paper is a particular kind of innovation network, as yet relatively unknown but that is developing against the background of economies dominated by service industries; we term them public-private innovation networks in services (ServPPINs). Such networks involve collaborations between public and private service organizations in the field of innovation. They differ from traditional INs in several ways. Firstly, service providers are the main actors in the networks. Secondly, the relationships between the public and private actors lie at the heart of the analysis. Finally, non-technological innovation, which is often overlooked in the literature, is taken into account. This paper has a twofold purpose: first, to examine the way in which the characteristics of ServPPINs can help to modify and enhance the traditional concept of IN, and, second, to draw any possible lessons there might be for public policy. It is based on both a literature survey and analysis of a database of ServPPINs case studies compiled over the course of the ServPPIN (Public Private Innovation Networks in Services) European project.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":169294051,"openaccessinfo":{"externalids":{"MAG":"2911240157","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A programmable operational amplifier (OpAmp) concerning noise and power consumption is described. Key design issues for achieving programmability of a preselected OpAmp architecture are discussed. Experimental results for a 0.35 mum CMOS OpAmp show either ultra low noise of 2 nV\/radicHz or low power consumption of 140 muW. The OpAmp remains stable over the whole range of programmability","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":26908625,"openaccessinfo":{"externalids":{"MAG":"2117324660","ACL":null,"DOI":"10.1109\/ESSCIR.2006.307607","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In order to solve the two-sided matching problem based on uncertain score information, a new method is presented. Firstly, the description of the two-sided matching problem with uncertain scores is given. Secondly, the satisfaction degrees of each agent towards the agents on the other side are calculated. A multi-objective optimization model to maximize the satisfaction degrees of agents is set up. Considering the important degree of each agent in each side, the multi-objective optimization model is transformed into a bi-objective optimization model. Furthermore, the bi-objective optimization model is transformed into a single-objective model by using the linear weighted method. The matching alternative can be determined by solving the single-objective model. Lastly, an example is given to illustrate the validity of the proposed method.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":88490946,"openaccessinfo":{"externalids":{"MAG":"2187581709","ACL":null,"DOI":"10.14257\/IJMUE.2014.9.12.18","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Nowadays, faeces and urine are considered as noxious and unhealthy. In ancient times, however, urine and excrements were seen as undangerous and even useful; urine for textile production and excrements for agriculture. The Romans constructed sewers like the Cloaca Maxima, in the first place to remove (rain)water and drainage. Only later, toilets were connected to these sewers to remove the smell of urine and excrements. The idea that sewers were constructed with the specific aim of removing urine and excrements is therefore no longer valid, but the memory of this function of the (Roman) sewers was maintained in the Middle Ages. From the Renaissance onwards, city planners developed their 'ideal cities'. In these cities, there was no place for the dirty smell of urine and excrements, so subterranean sewers had to be constructed. Yet such ideas proved difficult to implement in the Dutch context. The Dutch engineer Simon Stevin realised that the situation described by the ancient and Renaissance sources did not offer a solution for the problems in Dutch cities, with standing water in canals and without natural drainage. Moreover, in this period there was not yet an awareness of the relation between the presence and smell of urine and excrements, on the one\u00a0 hand, and hygiene and public health on the other. Awareness of this relation came not earlier than the 18th century. The German physician Johann Peter Frank argued in favour of diminishing the bad smell by\u00a0 means of filling up canals; the city physician Willem Frederik Buchner was confronted with the extremely unhealthy situation in the typical Dutch city of Gouda. But their political influence was small. Only at the end of the 19th century, the construction of sewers began in Dutch cities, thus \u2013 improving health conditions.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":143264116,"openaccessinfo":{"externalids":{"MAG":"1836888783","ACL":null,"DOI":"10.18352\/STUDIUM.8085","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"'Dear Professor, very nice to see you. But, before you sit down, just one question: is Communism really finished?' Gulf minister to author on visit to region, April 1999 Into the 1990s: international change, regional consequences The course of events in the Middle East from the end of the Cold War (1991) to the early 2000s (2003) was, above all, framed by four dramatic, regional and, in their impact, global, developments: the Iraqi invasion of Kuwait on 2 August 1990, the signing of the Israeli\u2013Palestinian Declaration of Principles on 13 September 1993; the al-Qa'ida attack on the USA on 11 September 2001; the Anglo-US occupation of Iraq in March\u2013April 2003. The first was an act of inter-state war that divided the region itself and drew external forces into regional conflict more directly than at any time since 1918. The Kuwait war of 1990\u20131, the Third Gulf war, prevented one possible course of history in that it checked Iraqi ambitions and restored the sovereignty of Kuwait. Yet while the immediate occasion for the conflict, the Iraqi occupation of Kuwait, was resolved, with the expulsion of Iraqi forces at the end of February 1991, the aftermath was to leave many issues unresolved. Not least among these was the international standing of Iraq itself, which was subjected to intrusive inspection and elaborate sanctions. The tinder of further conflicts remained, only to be concluded in 2003.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":262857661,"openaccessinfo":{"externalids":{"MAG":"2242340470","ACL":null,"DOI":"10.1017\/CBO9780511790829.006","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Trade liberalization policy was analyzed to examine the effects on performance of Small and Medium Scale (SMS) food processing enterprises located in the Greater Accra Region of Ghana from 1970 - 2003. Thirty-three SMS food processing companies were purposively sampled, and the results show a U-shaped trend in the number of registered firms, overall growth rate of 4.3 % in the number of food processors, a negative growth rate of 1.8 % between 1970 and 1982 and a positive growth rate of 15.3 % between 1983 and 2003. Processing of fruits and vegetables was the most common venture, with 49 % being limited liability companies producing mainly for the domestic market. The Majority of food processors (i.e. 94 %) were established after the introduction of trade liberalization policy in 1983, and about 67 % sourced raw materials locally and 55 % financed businesses from own savings and profits. The trade liberalization policy had a positive effect on the output growth of SMS food processing companies. Capital was identified as\nthe major constraint affecting growth of food processors, but provision of tax relief, lower import tariff and financial support would enhance competitiveness of the processors. Journal of Business Research Vol. 1 (1&2) 2007: pp. 49-60","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":154045799,"openaccessinfo":{"externalids":{"MAG":"1565318147","ACL":null,"DOI":"10.4314\/JBR.V1I1.41454","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Two dimensional quantitative structure activity relationship (2D-QSAR) and three dimensional quantitative structure activity relationship (3D-QSAR) studies by means of Multiple Linear Regression (MLR), Partial Least Square (PLS) and Principal Component Regression (PCR) were performed on a series of 4-Alkoxycarbonyl-1, 5- diaryl-1, 2, 3-triazole analogues for the treatment of drug abuse disorder using software MDS 4.2 version (VLife Science). This study was performed with 13 compounds (Data set) using random as well as manual data selection methods for the division of the data into training and test set. MLR methodology with stepwise (SW) forwardbackward variable selection method was used for building the QSAR models. Statistically significant QSAR models were generated. Among them most significant model has squared correlation coefficient (r2) = 0.9895, cross validated correlation coefficient (q2) = 0.9747 and predictive correlation coefficient (pred_r2) = 0.9826 for the treatment of drug abuse disorders. The core idea of the present study is the search for novel 4-Alkoxycarbonyl-1, 5- diaryl-1, 2, 3-triazole analogues that would show promise to be useful in the treatment of drug abuse disorders.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":54224672,"openaccessinfo":{"externalids":{"MAG":"2601159914","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We implement a quantum error correction algorithm for bit-flip errors on the topological toric code using deep reinforcement learning. An action-value Q-function encodes the discounted value of moving a defect to a neighboring site on the square grid (the action) depending on the full set of defects on the torus (the syndrome or state). The Q-function is represented by a deep convolutional neural network. Using the translational invariance on the torus allows for viewing each defect from a central perspective which significantly simplifies the state space representation independently of the number of defect pairs. The training is done using experience replay, where data from the algorithm being played out is stored and used for mini-batch upgrade of the Q-network. We find performance which is close to, and for small error rates asymptotically equivalent to, that achieved by the Minimum Weight Perfect Matching algorithm for code distances up to d=7. Our results show that it is possible for a self-trained agent without supervision or support algorithms to find a decoding scheme that performs on par with hand-made algorithms, opening up for future machine engineered decoders for more general error models and error correcting codes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":119102420,"openaccessinfo":{"externalids":{"MAG":"2951550064","ACL":null,"DOI":"10.22331\/q-2019-09-02-183","PubMedCentral":null,"ArXiv":"1811.12338"},"license":"CCBY","url":"https:\/\/quantum-journal.org\/papers\/q-2019-09-02-183\/pdf\/","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The present study aimed to investigate the reliability and factor structure of the self-regulating capacity in vocabulary learning strategies scale (SRCvoc) in the Iranian EFL context. To this end, the original (SRCvoc) questionnaire (Tseng, Dornyei, & Schmitt, 2006) was translated into Persian, using a translation\/back-translation procedure. Then, the Persian version of the SRCVOC was piloted to 43 high school students and showed acceptable internal consistency reliability (\u03b1 = .81). In the main phase of the study, a sample of 1167 high school students (grades 9-12) from fifteen high schools in three Iranian cities completed the Persian SRCvoc. Based on the results, the Persian version of the scale demonstrated acceptable internal consistency reliability (\u03b1 = 0.81). The factor structure of the translated version of the measure was investigated through a series of factor analyses. The results showed that the translated SVLSQ is composed of one dimension with five subcomponents, with a different factor structure as compared to the original questionnaire. The findings of the study suggest that the Persian version of the SVLSQ is a reliable and valid instrument for measuring self-regulatory vocabulary learning strategies in Iran.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":149211724,"openaccessinfo":{"externalids":{"MAG":"2742207300","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We consider the problem of approximate Bayesian inference in log-supermodular models. These models encompass regular pairwise MRFs with binary variables, but allow to capture highorder interactions, which are intractable for existing approximate inference techniques such as belief propagation, mean field, and variants. We show that a recently proposed variational approach to inference in log-supermodular models -L-FIELD- reduces to the widely-studied minimum norm problem for submodular minimization. This insight allows to leverage powerful existing tools, and hence to solve the variational problem orders of magnitude more efficiently than previously possible. We then provide another natural interpretation of L-FIELD, demonstrating that it exactly minimizes a specific type of Renyi divergence measure. This insight sheds light on the nature of the variational approximations produced by L-FIELD. Furthermore, we show how to perform parallel inference as message passing in a suitable factor graph at a linear convergence rate, without having to sum up over all the configurations of the factor. Finally, we apply our approach to a challenging image segmentation task. Our experiments confirm scalability of our approach, high quality of the marginals, and the benefit of incorporating higher-order potentials.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":1832772,"openaccessinfo":{"externalids":{"MAG":"1825385198","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"1502.06531"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"According to GB\/T17138-1997 method,the copper content in soil was determined.The factors affecting uncertainty of the determination were analyzed,and the uncertainty of the determination result of a sample was evaluated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":100160644,"openaccessinfo":{"externalids":{"MAG":"2390364131","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 101st Annual Meeting 2010\u2010\u2010 Apr 17\u201021, 2010; Washington, DC\n\nEvasion of apoptosis is a hallmark of chronic lymphocytic leukemia (CLL), calling for new concepts to overcome apoptosis resistance. We therefore investigated whether targeting the antiapoptotic protein XIAP by small molecule inhibitors would sensitize for apoptosis. Here, we provide first evidence that XIAP inhibitors in combination with the death receptor ligand TRAIL present a new strategy to synergistically trigger apoptosis in CLL even in subgroups with resistant disease.\n\nAnalysis of apoptosis regulatory proteins reveals that XIAP, cIAP1 and cIAP2 are expressed at high levels in primary CLL samples. Proofs of concept studies in CLL cell lines demonstrate that subtoxic concentrations of several distinct XIAP inhibitors significantly enhance TRAIL-induced apoptosis. By comparison, no sensitization for death receptor-induced apoptosis is observed in the presence of a structurally related control compound that only weakly binds to XIAP, demonstrating the specificity of the sensitization effect of XIAP inhibitors. Importantly also in primary CLL samples, subtoxic concentrations of XIAP inhibitors act in concert with TRAIL to trigger apoptosis in 18 of 27 cases (67%), whereas primary CLL cells are resistant to treatment with TRAIL alone. Analysis of combination index reveals that this interaction of XIAP inhibitor and TRAIL is highly synergistic. Mechanistic studies in primary CLL cells show that the addition of XIAP inhibitor profoundly enhances TRAIL-induced cleavage of caspase-3 into active fragments and significantly increases caspase-3 enzymatic activity. The broad range caspase inhibitor zVAD. fmk completely blocks apoptosis in response to combination treatment with XIAP inhibitor and TRAIL, pointing to caspase-dependent apoptosis. Intriguingly, the cooperative interaction of XIAP inhibitor and TRAIL is even evident in several distinct subgroups of CLL patients with poor prognostic features, including patients with 17p deletion, TP53 mutation, chemotherapy-refractory disease or unmutated VH genes. Interestingly, we found that cases with unmutated VH genes are significantly more sensitive to XIAP inhibitor- and TRAIL-induced apoptosis compared to VH gene mutated samples, pointing to a role of B-cell receptor signaling in the regulation of apoptosis in CLL cells. In conclusion, we provide first evidence that XIAP inhibitors in combination with TRAIL present a novel strategy to trigger apoptosis even in resistant forms and poor prognostic subgroups of CLL. These findings have important implications for the development of innovative approaches to overcome the intrinsic resistance to apoptosis in CLL. Since IAP inhibitors as well as TRAIL receptor agonists as single agents are currently already under evaluation in early clinical trials, it is feasible that such combination protocols of XIAP inhibitors and TRAIL could be translated into clinical application in CLL.\n\nNote: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4508.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":75263274,"openaccessinfo":{"externalids":{"MAG":"2325626263","ACL":null,"DOI":"10.1158\/1538-7445.AM10-4508","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES To evaluate the validity of the checklist individual strength questionnaire (CIS) in the working population. This 20 item self reported questionnaire has often been used in patients with chronic fatigue. To date, no research has focused on the validity of the CIS in occupational groups. METHODS To evaluate the discriminant validity the CIS was filled out by five groups of employees with expected differences in fatigue. The convergent validity was evaluated by comparing the results of the CIS with the results of three related measures: measured unidimensional fatigue, burnout, and need for recovery. RESULTS The CIS was able to discriminate between fatigued and non-fatigued employees in occupational groups. The expected agreement between the results of the CIS and related measures was confirmed. CONCLUSIONS The CIS seems to be an appropriate instrument for measuring fatigue in the working population.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":33169955,"openaccessinfo":{"externalids":{"MAG":"2060384003","ACL":null,"DOI":"10.1136\/oem.57.5.353","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/oem.bmj.com\/content\/oemed\/57\/5\/353.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The fundamental plane for black hole activity constitutes a tight correlation between jet power, X-ray luminosity, and black hole mass. Under the assumption that a Blandford-Znajek-type mechanism, which relies on black hole spin, contributes non-negligibly to jet production, the sufficiently small scatter in the fundamental plane shows that black hole spin differences of $\\mid$$\\Delta$a$\\mid \\sim$1 are not typical among the active galactic nuclei population. If $-$ as it seems $-$ radio loud and radio quiet objects are both faithful to the fundamental plane, models of black hole accretion in which the radio loud\/radio quiet dichotomy is based on a spin dichotomy of a$\\sim$1\/a$\\sim$0, respectively, are difficult to reconcile with the observations. \nWe show how recent theoretical work based on differences in accretion flow orientation between retrograde and prograde, accommodates a small scatter in the fundamental plane for objects that do have non-negligible differences in black hole spin values. We also show that the dichotomy in spin between the most radio loud and the most radio quiet involves $\\mid$$\\Delta$a$\\mid \\approx$0. And, finally, we show how the picture that produces compatibility with the fundamental plane, also allows one to interpret other otherwise puzzling observations of jets across the mass scale including 1) the recently observed inverse relation between radio and X-rays at higher Eddington ratios in both black hole X-ray binaries as well as active galactic nuclei and 2) the apparent contradiction between jet power and black hole spin observed in X-ray hard and transitory burst states in X-ray binaries.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":29265374,"openaccessinfo":{"externalids":{"MAG":"2028400095","ACL":null,"DOI":"10.1093\/mnras\/stu1086","PubMedCentral":null,"ArXiv":"1406.2778"},"license":null,"url":"https:\/\/academic.oup.com\/mnras\/article-pdf\/442\/4\/3097\/4167431\/stu1086.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"This paper interprets dispute settlement procedures and punishments as responses to the fact that trade agreements are incomplete contracts. I argue that this can explain prominent features and has implications for trade agreements. If no weight is given to the adjudication phase and if the degree of trade relatedness is known with certainty, the negotiated trade agreement will induce violation of the dispute settlement ruling and will deliver optimal liberalization and the optimal unilateral action. This suggests a central role, in multilateral trade liberalization, for an implicit agreement to allow countries to violate commitments if the violation implies no retreat from reciprocity. With the adjudication phase of concern the trade agreement will feature less liberalization. There is a presumption that the optimal trade agreement features commensurate punishment, or approximately commensurate punishment. The optimal trade agreement will likely induce abiding by the ruling when the negotiators attach more importance to the adjudication phase, and violating it when they attach less.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":264641111,"openaccessinfo":{"externalids":{"MAG":"1986171870","ACL":null,"DOI":"10.2139\/ssrn.273212","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to develop a short screening battery that would predict whether older children would show significant impairment on comprehensive neuropsychological testing. The screening battery was subdivided into two phases. Phase 1 was intended as a broad catchment effort; Phase 2 was designed to be a more detailed and selective procedure. Administration of the full set of screening tests requires about 45 minutes. Their predictive validity was assessed using the Neuropsychological Deficit Scale (NDS), which summarizes results in the entire Halstead-Reitan Neuropsychological Test Battery for Older Children. Cutoff scores and guidelines for interpretation of the screening tests were developed, and the results were substantially correct in identifying children who performed normally versus children who were impaired on the testing and therefore required comprehensive testing to evaluate their neuropsychological status and deficits.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29976477,"openaccessinfo":{"externalids":{"MAG":"2111403412","ACL":null,"DOI":"10.1080\/09084280801917137","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Preventing youth from initiating tobacco use is a key aspect of all tobacco prevention efforts. Most smokers become tobacco dependent before age 18 years. The purpose of the present study was to investigate thoughts of high school children about smoking behaviours and antismoking policies in Turkey. 731 students volunteered (336 male, 395 female, mean age 16,20\u00b11,15) to participate in the study from 7 different high schools. After taking written consent from their parents all the students filled the 16 item questionnaire developed by the researchers. 72.7 % of the students thought that their teachers were not good models for not smoking. 10.9 % believed that smoking is a sign of growing up and 45,7 % the students believed that they can quit whenever they wanted if smoked. 85 % of the students totally or partially agreed with the prohibition of cigarette advertising and 95.4 % of the students agreed with the prohibition of smoking in public places but 42.8 % of the students believed that smoking on the streets is not a stimulating behavior. 30.6 % did not think that increasing the cigarette prices would not have positive effect on decreasing smoking rates. 10 % and 12 % of the students thought that water pipe and light cigarettes are less harmful than the normal cigarettes respectively. A clear opportunity for intervening with youth lies in the school setting, and so besides the ban policies, comprehensive tobacco control and education programs including the parents should be initiated.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":70988314,"openaccessinfo":{"externalids":{"MAG":"1943003786","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The overall objective of EQLIPSE, a European Commission funded research and development project, was to specify, develop and validate an open IT-based system to support quality management and performance measurement in libraries of all types. The system is based on a client\/server architecture and offers compatibility with library systems from various library suppliers. The project has operated through a series of six phases, as follows: 1) Library requirements analysis , in which a series of tasks have been brought together expertise from the 10 partners and associates with internationally recognised quality management, library performance measurement and technological perspectives to define the libraries requirements from EQLIPSE and hence the groundwork for development; 2) Initial functional specification , in which the technical issues, including networking and systems integration, have been reviewed, leading to the production of an initial functional specification; 3) Prototype system , in which the initial functional specification has been used to design and build a prototype, functional system; 4) Data tools and data collection , in which the partners have adapted and designed tools for collecting data, supplementary to that contained in their operational IT-based systems, and built up a test dataset for use with the system; 5) Field trials and evaluation , in which the prototype system was installed in two libraries, debugged and developed into a fully functional system; 6) Integration in libraries , in which the debugged system was fully trialled, in a pseudo operational environment, in six libraries representing the different types, and evaluated. The project has involved ten partners, co-ordinated by the University of Central Lancashire (UK): Dynix Ltd, the Microelectronics Applications Centre, Dublin City University (Ireland), University of Munster, Stadtbuchereien Dusseldorf (Germany), Copenhagen Business School Library (Denmark), Biblioteca Nazionale Centrale of Rome (Italy), Stockholm University Library (Sweden), University of the Aegean (Greece). The final result was the implementation of two different modules, one for quality management (Quality Workbench), and one for performance measurement (Performance Workbench). The first module (QW), consisting of 7 functions - System Manager , Document Control , Personnel , Customer , Customer Complaints , Nonconformities , Audits - is a support for quality management positions in libraries and allows both documents circulation and procedures control. This software was specifically designed to facilitate strict adherence to the ISO 9000 quality standard and for this reason non ISO 9000 compliant environments may find its functionalities restrictive or unsatisfactory. The second package (PW) was developed starting from the analysis of the principal sources on performance indicators, first af all the ISO 11620 standard, integrated with data selected from other seminal works on the subject. The result of this process was a list of 52 indicators (but it is an open list, with chance of increasing by the user) and a second list of datasets necessary to calculate the indicators. The module allows both data download from libraries automated systems and manual data entry. The project, started in February 1995, was concluded in March 1997.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-18":1}},"corpusid":109137021,"openaccessinfo":{"externalids":{"MAG":"1842884860","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"One discovers why the solution of generalized umbral calculus difference nonhomogeneous equation in the form recently proposed by the author extends here now to generalized appellian delta operator and corresponding polynomials case almost automatically. The reason for that is just the proper framework of the generalized finite operator calculus recently being developed by the present author.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118711684,"openaccessinfo":{"externalids":{"MAG":"1640358738","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Antenatal detection of congenital pulmonary airway malformations (CPAM) has improved immeasurably from its initial application in the 1980s and probably encompasses >80% of all such lesions. Accurate diagnosis still remains less reliable and definitive diagnosis requires detailed anatomical imaging (typically with CT scan) in the post-natal period. About 10% of all lesions will present with symptoms during the neonatal period and the choice of surgical intervention is then easy. For those that remain asymptomatic then there is still a degree of controversy about elective surgical resection. This article presents the case for elective surgery within the first year of life and aims to quantify the risks of non-intervention such as abscess, empyema, recurrent pneumonia, air-leak, and pneumothorax and various types of malignancy in such cases. The current surgical approach now includes both open muscle-sparing thoracotomy and thoracoscopic resection.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29093617,"openaccessinfo":{"externalids":{"MAG":"1994987187","ACL":null,"DOI":"10.1053\/j.sempedsurg.2015.02.003","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"In this paper, we analyze the capacity of delaysensitive services in forward link of TDMA system when multiuser packet (MUP) is used. A new transmission strategy based on two buffers is proposed to meet the stringent quality of service (QoS) requirement. Besides, we employ a throughput optimal scheduler in a constrained delay boundary to achieve a good balance between throughput and latency. The delay boundary in our analysis is defined as the longest time a packet may experience, including waiting time in a buffer and transmission time over the air interface. Our scheduler purely relies on subscribers' channel condition which has an analogy to maximum C\/I. According to the buffer-based transmission and channel condition-oriented scheduler, we develop an analytical model and give the numerical results in the end. Keywordscapacity; delay-sensitive; MUP; TDMA","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21391209,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/VETECF.2007.245","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: The SIGN (Scottish Intercollegiate Guidelines Network) guidelines on axillary surgery do not advise as to whether level 1\/2 or level 3 clearances should be performed when axillary clearance is required. Although there is a theoretical risk of increased morbidity, in experienced hands a level 3 clearance reduces the chance of residual tumour and allows for full staging. Materials and Methods: 124 consecutive axillary clearances (level 1, 2 and 3) were performed by a single operator. Level 1 and 2 nodes were removed as a single specimen, with level 3 nodes removed separately. Patient case notes, operation notes and pathology reports were used in the collection of data and all data were recorded in an Excel database Results: Of the 124 axillary clearances performed, 64 (52%) had level 1\/2 lymph nodes positive for carcinoma. Of these 64 patients, 14 (11%) also had positive level 3 nodes. One patient (1%) had negative level 1\/2 nodes but positive level 3 nodes. The Nottingham Prognostic Index (NPI) value increased in two patients when the level 3 nodes were included (6.6 to 7.6 and 4.3 to 5.3). Discussion: While it is generally accepted that axillary radiotherapy deals with residual level 3 nodal involvement, basic surgical oncologic principles would suggest that removal of as much tumour as possible should be performed. The patient with positive level 3 nodes but negative level 1\/2 nodes would have been under-treated, with viable tumour remaining. Furthermore, the under-estimate of the NPI when level 3 nodes are not included could lead to sub-optimal adjuvant therapy being offered. The performance of a level 3 clearance can preclude the need for axillary radiotherapy, thereby reducing morbidity. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3114.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":71774649,"openaccessinfo":{"externalids":{"MAG":"2032402696","ACL":null,"DOI":"10.1158\/0008-5472.SABCS-09-3114","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"FPGAs, as computing devices, offer significant speedup over microprocessors. Furthermore, their configurability offers an advantage over traditional ASICs. However, they do not yet enjoy high-level language programmability, as microprocessors do. This has become the main obstacle for their wider acceptance by application designers. ROCCC is a compiler designed to generate circuits from C source code to execute on FPGAs, more specifically on CSoCs. It generates RTL level HDLs from frequently executing kernels in an application. In this paper, we describe the ROCCC's system overview and focus on its data path generation. We compare the performance of ROCCC-generated VHDL code with that of Xilinx IPs. The synthesis result shows that the ROCCC-generated circuit takes around 2\/spl times\/\/spl sim\/3\/spl times\/ the area and runs at a comparable clock rate.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":5068788,"openaccessinfo":{"externalids":{"MAG":"2952564728","ACL":null,"DOI":"10.1109\/DATE.2005.234","PubMedCentral":null,"ArXiv":"0710.4716"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We propose a novel fabrication methodology for a hermetic sealing device using an O2 plasma-assisted low temperature Intrinsic-Silicon (I-Si) and glass bonding technique. Glass substrates were used as the cap and base wafers, while I-Si was applied selectively to the contact surface of the cap wafer as an interlayer. A 180-\u03bcm-deep cavity was formed in the cap glass by wet etching using a double-layer (photoresist\/I-Si) etching mask. I-Si\/glass bonding was conducted at 200\u00b0C using an I-Si layer-covered glass wafer and a bare glass wafer. Water contact angle measurements and tensile test results showed that the bonding strength increased with promoting surface hydrophilicity through O2 plasma pretreatment. Moreover, scanning acoustic microscope observations revealed that I-Si\/glass bonding was achieved successfully without significant voids. Our results indicate that the proposed method could become an indispensable technique for future functional hermetic sealing devices.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":138269683,"openaccessinfo":{"externalids":{"MAG":"2326621756","ACL":null,"DOI":"10.5104\/JIEPENG.8.74","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9), a member of the proteinase K subfamily of subtilases, promotes internalization and degradation of low density lipoprotein receptors (LDLRs) after binding the receptor on the surface of hepatocytes. PCSK9 has autocatalytic activity that releases the prodomain at the N terminus of the protein. The prodomain remains tightly associated with the catalytic domain as the complex transits the secretory pathway. It is not known whether enzymatic activity is required for the LDLR-reducing effects of PCSK9. Here we expressed the prodomain together with a catalytically inactive protease domain in cells and purified the protein from the medium. The ability of the catalytically inactive PCSK9 to bind and degrade LDLRs when added to culture medium of human hepatoma HepG2 cells at physiological concentrations was similar to that seen using wild-type protein. Similarly, a catalytic-dead version of a gain-of-function mutant, PCSK9(D374Y), showed no loss of activity compared with a catalytically active counterpart; both proteins displayed \u223c10-fold increased activity in degradation of cell surface LDLRs compared with wild-type PCSK9. We conclude that the ability of PCSK9 to degrade LDLRs is independent of catalytic activity and suggest that PCSK9 functions as a chaperone to prevent LDLR recycling and\/or to target LDLRs for lysosomal degradation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":42598947,"openaccessinfo":{"externalids":{"MAG":"2076695593","ACL":null,"DOI":"10.1074\/jbc.C700095200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Vinblastine, a transport blocker, was applied locally to the sciatic nerve in rats. It was found to be a powerful neurotoxin with a dose- dependent action, destroying all afferents at doses of 5 X 10(-4)M, primarily C fibers at intermediate doses of 2.5 X 10(-4)M, and only at a critically low dose of 10(-4)M was a degeneration-free axon transport blockade, lasting for 4 to 5 days, produced. Such transport block failed to alter thermal responsiveness of the rats as measured behaviorally, by the flexor reflex, or by dorsal horn cell responses. It did, however, significantly reduce both the chemical sensitivity of the C afferents and their ability to produce neurogenic edema. This began 24 hr after treatment and lasted 4 to 5 days. Therefore, it is likely that these functions are dependent on the continuous transport of some compound to the axon terminals from the cell body. This low concentration of local vinblastine treatment also resulted in depletion of fluoride-resistant acid phosphatase from C fiber terminals in the dorsal horn of the spinal cord. Transmission from C fibers to second- order neurons in the spinal cord, however, was totally unaffected. Substance P levels in the spinal terminals was largely unaffected, although in 1 of 5 cases there was depletion. It appears, therefore, that some, but not all, retrograde changes in sensory neurons following peripheral nerve damage can be mimicked by blockade of axon transport. The effects following vinblastine treatment are compared to other peripheral nerve manipulations, such as cut, crush, and application of local capsaicin.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":13945460,"openaccessinfo":{"externalids":{"MAG":"2109479896","ACL":null,"DOI":"10.1523\/JNEUROSCI.04-02-00430.1984","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Chronic pulmonary blastomycosis is often misdiagnosed and treated as tuberculosis in disease-endemic and non\u2013disease-endemic areas. We report the case of a 32-year-old man who after visiting Chicago, Illinois, USA, returned to India and received treatment for tuberculosis for 12 months before receiving the correct diagnosis of blastomycosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201202596,"openaccessinfo":{"externalids":{"MAG":"2965534792","ACL":null,"DOI":"10.3201\/EID2509.190587","PubMedCentral":"6711241","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Government imposition of restrictive rules is a fact of life in parliamentary democracies. In a novel data set for the study of the parliamentary passage of legislation (SPPL) in western Europe no less than 80 of 512 bills were enacted by some kind of restrictive rule across 17 parliamentary systems. These highly variegated restrictions consist of two distinct types: rules governing amendment control and restrictions on the timetable. Both types of restrictive rules are frequently employed to create 'party discipline by default' in incohesive parties. Referring to formalised rational-choice theories of parliamentary behaviour, seven empirically testable hypotheses are derived and subsequently subjected, with bills as units of analysis, to logistic regression of the likelihood of restrictions being imposed. Of the seven hypotheses, two are rejected and five confirmed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":219628010,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1080\/1357233042000306317","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Dementia with Lewy bodies (DLB) is a common form of dementia that is being increasingly recognized. This paper reviews this disorder, emphasizing how it is different from other causes of dementia.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":17339508,"openaccessinfo":{"externalids":{"MAG":"2125173895","ACL":null,"DOI":"10.3949\/CCJM.71.10.789","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"During the last decades, the milk production per cow has increased while fertility and mounting behavior have decreased in Holstein cows. Voluntarily delaying rebreeding to a period where the cow is in positive energy balance might help improving pregnancy rates. To overcome the problems associated with estrus detection, the use of a double artificial insemination (AI) technique, where cows are inseminated 1 or 2 days apart, have previously been applied but with inconsistent results. The two main objectives of the present study were: (1) to determine if the pregnancy rates were improved when delaying rebreeding to 8 months after calving compared with cows inseminated at around 2 months after calving; and (2) to evaluate the effect of a double AI technique around estrus on the pregnancy rates compared with the use of a single AI per estrus. The dataset comprised 235 observations, each representing one AI, from 62 cows followed for consecutive lactations of 10 months (early rebreeding at 2 months) and one lactation of 16 months (late rebreeding at 8 months). The double AI technique was applied in 41% of the AI recorded. The results showed that even though more cows tended to express mounting behavior at the late rebreeding compared with the early rebreeding (63.3 vs 45.9% respectively, P=0.06), the pregnancy rate at first AI was not improved (40.0 vs 38.7% respectively, P=0.27). The cows receiving the double AI technique had a lower pregnancy rate compared with the cows receiving a single AI per estrus (45.8 vs 63.8 respectively, P<0.01). Moreover, use of the double AI technique induced confusion as how to report the reproductive performance in the herd, taking into account the total number of insemination\/success or considering only one value per estrus. To conclude, delaying rebreeding to 8 months increased mounting behavior at AI time, but did not increase pregnancy rate at first AI. The double insemination technique had a negative effect on the pregnancy rate at first AI.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226977331,"openaccessinfo":{"externalids":{"MAG":"3043325114","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper deals with economic analyses of two mining projects in Australia \u2013 one on the Liverpool Plains in New South Wales and the other on the Galilee Basin in Central Queensland. The adverse environmental and social externalities of these projects are well known \u2013 especially the impacts on the Gunnedah and the Great Artesian Basins. Notwithstanding these impacts, private financial analyses demonstrate significant revenue gains to the mining firms and render expenditures on mining to be sound investments. Nevertheless, economic analyses illustrate that the net benefits to Australia are possibly absent even without accounting for environmental social externalities. Given that the property rights of the mineral reserves are vested with the State, the Resource Rent Tax (RRT) becomes a legitimate fiscal policy tool. The paper argues that the assessment of mining decisions, must account for the depreciation of the Mineral asset. When this depreciation is measured by recourse to the Hartwick-Rule, the mining projects demonstrate monetary viability only when the RRT is enforced and is invested in its entirety on options that generate annual returns in excess of 4 per cent. Whilst environmental and social externalities would readily wipe out this monetary viability, it is noteworthy that such viability is clearly absent for rates of investment less than 3 per cent in the application of the Hartwick-Rule. Besides, with both projects, agriculture is a potentially dominant and viable alternative.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":158556496,"openaccessinfo":{"externalids":{"MAG":"2895540880","ACL":null,"DOI":"10.2139\/ssrn.3179880","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Majority of evaluation methods on interference temperature algorithms are based on the assumption that either the interference signals or the user's signals are no directions. This is a mathematical constraint that is not satisfied in many applications. In fact, without consideration the signal directions increase estimation interference temperature, that is, reduce the frequency utilizing chance for users. In this paper, we consider situations where the interference signals and user's signals have directions in cognitive radio sensor networks. We propose an algorithm that estimates the interference temperature of this model using a generalization of the DOA\u00bfdirection of arrival algorithm. From this, we find the interference temperature and show that it does become smaller. We compare our method to the conventional (without considering directions) algorithm. The simulation studies show that the new method outperforms the conventional algorithm by reducing the estimation interference temperature and improving the frequency spectrum efficiency.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":17772901,"openaccessinfo":{"externalids":{"MAG":"2125876642","ACL":null,"DOI":"10.1109\/ISECS.2009.10","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Implementing environmental activism at school can be socially risky business. This paper explores the narratives of three women who undertook award winning environmental projects in two regional Australian schools. Tara (student, age 15), Anne (student, age 15) and Andrea (principal, age 42) document the complex and courageous social negotiations they were forced to undertake in response to being negatively constituted as \"a greenie\" at school. Tara and Anne met resistance from their peers and family and Andrea fielded complaints from members of the local school community. This micro-qualtitative analysis shows that, despite the heartfelt rhetoric of environmental education, assuming an environmental identity at school can be problematic and difficult to enact. Environmental action is still not seen as a \"cool\" social practice in some adolescent peer groups. Nor is environmental action positioned as central to the \"legitimate\" practices of schooling in some communities. Successful projects rely on students and staff who are willing to actively, and persitently, negotiate social opposition to their achieving an ecological vision for school practice.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":231734913,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1017\/s0814062600002469","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"State-of-the-art axisymmetric drop shape analysis (ADSA) techniques for the computation of interfacial tensions and contact angles by fitting the Laplace equation of capillarity to the shape and dimensions of pendant and sessile drops are presented. More accurate, efficient, and reliable versions of the technique for the measurement of contact angles from the volume and diameter of sessile drops [axisymmetric drop shape analysis-diameter (ADSA-D)] and for interfacial tension measurements from a series of arbitrary profile coordinates of sessile and pendant drops [axisymmetric drop shape analysis-profile (ADSA-P)] have been developed. Advanced numerical methods have been used to improve the numerical stability and global convergence, for more accurate results and a wider range of applicability of the methods. A new technique called axisymmetric drop shape analysis-height and diameter (ADSA-HD) has been developed to estimate interfacial tensions from the height and diameter of sessile and pendant drops. Numerical simulations using numerically generated drop profiles were used to evaluate the accuracy and applicability of the methods. Copyright 1997 Academic Press.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15249724,"openaccessinfo":{"externalids":{"MAG":"2078078836","ACL":null,"DOI":"10.1006\/JCIS.1997.5214","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Due to the complex bloodstream components, tumor microenvironment and tumor heterogeneity, traditional nanoparticles have a limited effect (low drug delivery efficiency and poor penetration to the deeper tumor) on eradicating tumors. To solve these challenges, novel platelet membrane-coated nanoparticles (PCDD NPs) were constructed for combined chemo-photodynamic- and immunotherapy of melanoma. The platelet membrane imparted the PCDD nanoparticles with an excellent long circulation effect and tumor targeting ability, which solved the issues of low drug delivery efficiency. After reaching the tumor cells, it releases the drug-loaded CDD micelles, becoming positively charged and facilitating the deep penetration of tumors. Cytotoxic and apoptosis experiments showed that PCDD nanoparticles have the strongest tumor cell killing ability. Based on the excellent results in vitro, PCDD was used to assess anti-tumor and distal tumor inhibition in rat models. The results revealed that the PCDD combined PDT, immunotherapy and chemotherapy could not only inhibit the primary tumor growth (inhibition rate: 92.0%) but also suppress the distant tumor growth (inhibition rate: 90.7%) and lung metastasis, which is far more effective compared to the commercial Taxotere\u00ae. Exploration of the molecular mechanism showed that in vivo immune response induced an increase in positive immune responders, suppressed negative immune suppressors, and established an inflammatory tumor immune environment, leading to excellent results in tumor suppression and lung metastasis. In conclusion, this novel multifunctional PCDD nanoparticle is a promising platform for tumor combined chemotherapy, photodynamic therapy (PDT) and immunotherapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":252805728,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1039\/d2bm01291j","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The complexity and fragmented nature and the multiple stakeholders in the construction industry often make it difficult to come up with a firm decision regarding sustainable building materials selection. The wrong choice could negatively impact the project objective and performance outcome. This study assessed the critical factor influencing the choice of sustainable building materials (SBM) selection on construction projects in the Southeast geopolitical zone of Nigeria. Data were collected using a well-structured questionnaire, non-probability (purposive and snowball) sampling techniques, and an internet-mediated survey. Data analyses were carried out using the appropriate descriptive and inferential statistical tools and exploratory factor analysis (EFA). The study revealed recycled plastic, natural clay and mud, stone, bricks and tile, cellulose, stray bales, grasses, limestone, and wood timber, are the commonly used sustainable building materials. Also, their level of awareness is high while their adoption is moderate. EFA revealed that the major clusters of determinants of the choice of green building materials are: emissions minimisation, low running cost and reusability, low thermal and energy consumption efficiency, low cost and high health and safety consideration and waste minimisation. The key factors influencing the choice of sustainable building materials selection in construction are: reducing greenhouse gas emissions from buildings, materially embodied energy cost, operating and maintenance costs, non-toxic or low toxic emissions generated by the products\/materials, recyclability of the building materials, availability of the technical skills, renewable (reusable) properties, inhibiting the impact of buildings on the environment, safety and health of the occupants, and appearance and aesthetic. It is recommended that consideration be given to these factors in selecting sustainable\/green building materials in the designs and specifications of construction projects.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":245887755,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.14424\/ijcscm110221-166-194","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Increasing the share of renewables in energy markets influences the daily operation of thermal power units. High capacity power units are more frequently operated to balance power grids and, thus, steam boilers are exposed to unfavorable transient states. The aim of this work was to perform thermal and structural analyses of a boiler's outlet steam header, with a capacity of 650\u2219103 kg\/h (180 kg\/s) of live steam. Based on the measured steam pressure and temperatures on the outer surface of the component, transient temperature fields were determined by means of an algorithm that allows determination of transient stress distributions on the internal and external surfaces, as well as at stress concentration regions. In parallel, a finite element method simulation was performed. A comparison of the obtained results to a finite element analysis showed satisfactory agreement. The analyses showed that the start-up time could be reduced because the total stress did not exceed the allowed values during the regular start-up of the analyzed power unit. The algorithm was efficient and easy to implement in the real control systems of the power units. The numerical approach employed in the presented algorithm also allowed for determination of the time- and place-dependent heating rate value, which can be used as input data for the control system of the power unit.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":210919838,"openaccessinfo":{"externalids":{"MAG":"2997155085","ACL":null,"DOI":"10.3390\/en13010111","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/13\/1\/111\/pdf?version=1577364612","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Communication based on brain-computer interface (BCI) systems is still a challenge. Although most popular classes of BCIs heavily rely on electroencephalography (EEG), recent studies have demonstrated the feasibility of using functional near-infrared spectroscopy (fNIRS) as a reliable control signal in BCI systems. However, due to the inherent latency in hemodynamic responses, these systems are considerably slow. To address this issue, this study proposes an innovative oddball-based visio-mental task and investigates the feasibility of developing an fNIRS speller. The proposed paradigm derives its principles from the conventional oddball paradigm, which has been modified to include a set of mental arithmetic operations in the \"flash\" condition. Using statistical parametric mapping (SPM) and Pearson correlation analysis, the optimum channels and hemodynamic features were selected respectively. Linear discriminant analysis (LDA) was used to evaluate the performance of the proposed fNIRS-speller. Using 2 optimum channels, our analysis demonstrated the highest average accuracy of 78.5 \u00b1 5.7% within 2-4 seconds of the stimulation and an average accuracy of 77.0 \u00b1 8.9% only within the first 2 seconds. Achieving satisfactory performance while using only 2 channels and a 2-second window highlights the feasibility of developing a convenient and real-time fNIRS-speller. Such a system may have potential translational applications, particularly in users with a lack of eye gaze control.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":159042888,"openaccessinfo":{"externalids":{"MAG":"2945184345","ACL":null,"DOI":"10.1109\/NER.2019.8717030","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper categorizes and reviews different approaches to environmental impact assessment (EIA) system evaluation. It then describes the application of Wood's (1995) 'ideal' EIA system evaluation criteria to the Republic of Maldives. Few of the criteria are actually met. Is the Maldivian EIA system therefore fundamentally flawed or deficient? Field observations suggest that this is not so and, while many improvements can be made, the system is quite locally appropriate. It is concluded that there are a number of factors contributing to the positive development of the Maldavian EIA system, and these should be added on to Wood's list as supplementary criteria appropriate to small developing countries.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":130188366,"openaccessinfo":{"externalids":{"MAG":"2181624607","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This thesis presents the design and commissioning of a system to characterise the longitudinal beam properties of VELA (Versatile Electron Linear Accelerator) based around a transverse deflecting cavity, and the first measurements made using it. VELA at Daresbury Laboratory consists of an S-band RF photoinjector, which accelerates electrons to approximately 5 MeV\/c. VELA was intended as the injector for the CLARA Free Electron Laser test facility. The gun is operated in the ``blow-out'' regime, driven by a laser of pulse length 76 fs rms, with the electron beam distribution formed by the space-charge of the bunch. The transverse deflecting cavity is a 9-cell standing wave S-band cavity and the design was intended to provide 10 fs temporal resolution for the 250 MeV beam from CLARA. This thesis shows how the design of the cavity evolved via beam dynamics simulations to reduce unwanted transverse beam offset and momentum change through the cavity. Bunch length measurements are presented using the deflecting cavity to characterise the ``blow-out'' regime of the gun at bunch charges from 40 fC to 215 pC, and as a function of gun phase and beam momentum. Investigations into measurements of the longitudinal phase space distribution of the beam are also presented.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":189972554,"openaccessinfo":{"externalids":{"MAG":"2947878571","ACL":null,"DOI":"10.17638\/03031981","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"There is limited information on borderline ovar-ian tumor detected intra-surgically and its most favorable treatment in relation with global radiation and climate changes. Aim: To study the pre-surgery and intra-surgery differentia-tion criteria of borderline ovarian tumors from invasive carcinoma, and to make a very com-plex analysis of the frequency, distribution, and variation in time of global radiation, tem-perature, and precipitation in North-East Romania. Material and method: The 54 patients (age range 20-78 years, mean age 46 years) included in this study had borderline ovarian tu-mors surgically treated during the last 22 years (January 1988 - December 2009) at the 4th Gynecological Clinic at Iasi, and representing 4.87% of the total 1107 ovarian tumors de-tected and treated during this interval. The histological types were: serous (18 cases), mu-cinous (27 cases), mixed (8 cases), and Brenner tumor (1 case). In order to analyze the im-pact of climate changes on borderline ovarian tumors a thorough study on the frequency of global radiation in relation with climate changes based on data recorded in the last 55 years was also carried out. Results: The distribution of these cases depending on when surgery was performed was analyzed. In our study the frequency of ovarian borderline tumors (4.87%) is lower than in similar reports in the literature being due, in our opinion, to the in-fluence of global radiation in relation with climate changes. Conclusions: In our study glob-al radiation is probably responsible for a progression to invasive carcinoma in 0.7% of the borderline ovarian tumors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":155798859,"openaccessinfo":{"externalids":{"MAG":"2943402241","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we investigate a cell-free massive MIMO system with both access points and user equipments equipped with multiple antennas over the Weichselberger Rayleigh fading channel. We study the uplink spectral efficiency (SE) based on a two-layer decoding structure with maximum ratio (MR) or local minimum mean-square error (MMSE) combining applied in the first layer and optimal large-scale fading decoding method implemented in the second layer, respectively. To maximize the weighted sum SE, an uplink precoding structure based on an Iteratively Weighted sum-MMSE (I-WMMSE) algorithm using only channel statistics is proposed. Furthermore, with MR combining applied in the first layer, we derive novel achievable SE expressions and optimal precoding structures in closed-form. Numerical results validate our proposed results and show that the I-WMMSE precoding can achieve excellent sum SE performance.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":246294489,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/ICC45855.2022.9838843","PubMedCentral":null,"ArXiv":"2201.11299"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Sintering and lamination characteristics of Fe-Cu atomized powder have been investigated to meet requirements on recycling of automobiles and manufacture of lightweight structure. The greentape laser sintering method using Nd:YAG pulse laser and powder tape called \"greentape\" is employed for the fabrication of Fe-Cu porous structure. Extensively investigated is influence of laser parameters, such as voltage, pulse width and average power upon the state of liquid sintering or both surface texture and tensile strength of the sintered specimens. A water-atomized Fe-5mass%Cu powder (3-8\u03bcm in diameter) is superior to the gas-atomized Fe-2mass%Cu one (5-38\u03bcm) in monolayer strength, but being difficult to laminate due to the existence of massive pores. It is successful to laminate 16 layers of gas-atomized greentape (190\u03bcm in thickness each) at a voltage of 198V, a pulse width of 2.0ms and an average power of 13W. Porous structure can be controlled by changing these laser parameters, whereas it is necessary to resolve distortion of the sintered part by means of a segmented laser irradiation.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":138552485,"openaccessinfo":{"externalids":{"MAG":"2332164742","ACL":null,"DOI":"10.2497\/JJSPM.51.749","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The concept of quality is recognised as an essential tool in attaining operational efficiency and ultimate performance regardless of whether the product is tangible and intangible, like services. Many issues relating to the methodology for measuring the service quality emerged to make it operational. The presented research employs the SERVQUAL scale in gauging service quality of services offered by the water supply department of a municipal corporation. The research also attempts to validate its application. The service dimensions as prescribed by Parasuraman et al. (1985) employed as a measure of service quality. Five-point Likert scale measurement items in a questionnaire used to measure the service dimensions. Data was collected through a survey administered to service users. The principal component analysis (PCA) was performed to validate the factor classification. The gaps (Parasuraman et al., 1985) in the service as offered by the water supply department of a municipal corporation is calculated.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":116482801,"openaccessinfo":{"externalids":{"MAG":"2913334677","ACL":null,"DOI":"10.1504\/IJPQM.2019.10018902","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Many of today's scenic assessment tools were developed initially to preserve the visual quality of public lands and to mitigate the negative visual impacts of large-scale landscape alterations, such as timber harvesting, mineral extraction, and renewable energy production. However, we are beginning to see more interest today in preserving scenic views on non-public lands. This essay makes a case for additional scenic assessment tools that reveal deep meaning in the landscape. Deep meaning is different than the immediately visible attributes of the landscape. It includes things that come to mind when looking at the landscape and are shared by people familiar with that landscape. Understanding the concept of deep meaning can be difficult. The author describes how deep meaning in the landscape was first revealed to him. Two non-landscape examples are then used to demonstrate different aspects of deep meaning. First, the rocks in a rock garden show the personal nature and attachment of deep meaning. Second, the wording on two wine bottle labels illustrates the distinction between surface meaning and deep meaning. Poetry is then examined as a means of conveying deeper landscape meaning. Lastly, four different landscape contents categories that are used in the proposed Virginia Scenic Viewshed Program demonstrate how deep meaning content can be used in the scenic viewshed assessment. The conclusion is that deep meaning would be a valuable addition to the scenic assessment of non-public land viewsheds, particularly if the assessment process involves the public.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":252552930,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/land11101646","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2073-445X\/11\/10\/1646\/pdf?version=1664184519","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The censorship of toxic comments is often left to the judgment of imperfect models. Perspective API, a creation of Google technology incubator Jigsaw, is perhaps the most widely used toxicity classifier in industry; the model is employed by several online communities including The New York Times to identify and filter out toxic comments with the goal of preserving online safety. Unfortunately, Google's model tends to unfairly assign higher toxicity scores to comments containing words referring to the identities of commonly targeted groups (e.g., \"woman,'' \"gay,'' etc.) because these identities are frequently referenced in a disrespectful manner in the training data. As a result, comments generated by marginalized groups referencing their identities are often mistakenly censored. It is important to be cognizant of this unintended bias and strive to mitigate its effects. To address this issue, we have constructed several toxicity classifiers with the intention of reducing unintended bias while maintaining strong classification performance.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":220265897,"openaccessinfo":{"externalids":{"MAG":"3038299766","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"2006.16402"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim was to examine South Asian immigrants' beliefs, practices and experiences of childhood long-term conditions.\n This was an integrative review.\n MEDLINE, PsycINFO, PubMed, Scopus and Web of Science were searched for primary peer-reviewed articles published in English between January 2011 and April 2021.\n Articles were screened based on PRISMA guidelines. The quality of the studies was evaluated using the Critical Appraisal Skills Programme Checklist for qualitative studies and the Joanna Brigg's Institute Critical Appraisal Checklist for quantitative studies.\n Fourteen studies were included in the review. South Asian immigrant children and their family carers experienced cultural clashes as they attempted to incorporate their cultural beliefs about long-term conditions into a more westernized biomedical approach. Families were overburdened by caregiving and struggled to find additional support for their children. The main findings were categorized into three themes: (1) cultural beliefs; (2) religious, spiritual and complementary and alternative medicine practices and (3) care and support of the child.\n Health-care providers should use a combination of culturally safe management strategies and a nuanced approach to educational initiatives on the biomedical aspects of various long-term conditions to effectively engage South Asian immigrant families with health services.\n The growth of South Asians worldwide along with the increased burden of long-term conditions among South Asian immigrant children has implications for health service delivery. However, no reviews to date have explored South Asian immigrants' experience of childhood long-term conditions. Incorporating South Asian immigrants' beliefs and practices into the plan of care promotes collaborative decision-making that can lead to better treatment adherence, improved health outcomes and higher patient and family satisfaction. The findings encourage clinicians, researchers and policymakers to develop culturally safe child\/family-centred interventions to address the specific needs of South Asian immigrant children with long-term conditions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":247437968,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/jan.15217","PubMedCentral":"9314788","ArXiv":null},"license":"CCBY","url":"https:\/\/mro.massey.ac.nz\/bitstream\/10179\/18323\/1\/451684%20PDF.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Sixty-eight patients with different disorders of the cardiac rhythm were examined in ambulatory conditions. The complex of noninvasive examinations included: echocardiography, Holter monitoring, bicycle ergometry [correction of veloergometry] and transesophageal cardiostimulation with performance of diagnostic and pharmacological tests. The obtained data permitted to evaluate disorders of automatism and conduction at different levels of the cardiac conduction system, to identify paroxysmal tachyarrhythmia and realize selection of antiarrhythmic agents.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9800528,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Retraction: \"Smad4 gene silencing enhances the chemosensitivity of human lymphoma cells to adriamycin via inhibition of the activation of transforming growth factor \u03b2 signaling pathway\", by Qiuhuan Li, Xiaoyu Liu, and Chuanli Zhao, J Cell Biochem. 2019; 15098-15105: The above article, published online on 26 May 2019 in Wiley Online Library (https:\/\/doi.org\/10.1002\/jcb.28772) has been retracted by agreement between the journal's Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The retraction has been agreed after the authors stated that the experimental data in the article could not be verified. An investigation additionally revealed inconsistencies in several image elements. Thus, the editors consider the conclusions of this article to be invalid. The authors apologize for the errors.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221751343,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1096\/fj.06-6171fjeret","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1096\/fj.06-6171fjeret","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Physical activity is an important strategy for the management of diabetes type 2 mellitus. However, this recommendation is related to physical barriers. Diabetes mellitus type 2 patients showed lower scores in energy use, number of steps and duration of physical activity compared to healthy individuals. This study aimed to identify factors that affected physical activity among diabetes type 2 patients. A cross-sectional design was used in this study. This study was conducted in Kabupaten Tuban, East Java, Indonesia. A total of 105 diabetes type 2 patients followed the program Prolanis from the community health center. Data was collected using paper-based questionnaires, which were aslked the demographic characteristics, knowledge about physical activity, diabetes management self-efficacy, and international physical activity questionnaire (IPAQ) during March to October, 2020. Ordinal logistic regression was used to examine the factors that affected physical activity of diabetes type 2 patients. This study found that complication, knowledge and self-efficacy have significantly affected physical activity among diabetes type 2 patients. This information is beneficial to develop nursing care interventions and approaches to increase the physical activity of patients with type 2 diabetes mellitus.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":248911180,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.11591\/ijphs.v11i2.21154","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/ijphs.iaescore.com\/index.php\/IJPHS\/article\/download\/21154\/13513","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"On Relations between Dance and Movement: reflections about different meanings of movement and dance \u2013 This work resumes some ideas proposed by the dance critic and scholar Andr\u00e9 Lepecki (2008), in order to reflect about the limits of a refusal of movement as a rupture with modernity and with a certain notion of choreography. For this purpose, a critical reading of the way dance history is conceived in this work is made, and then three nuances for the notion of movement are proposed, in order to point out that the conjunction between dance and movement is neither univocal nor have always the same political or conceptual implications.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":194369168,"openaccessinfo":{"externalids":{"MAG":"2945545488","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The nonlinear parameter identification is studied using UKF and Maximun Likelihood (ML) method. The proposed scheme consists of two sequential stages. The first stage conducts the state estimation using UKF, where the estimated state is a function of unknown parameters. A likelihood function is constructed in the second stage based on the estimated state. Thereby, the parameter identification problem becomes an optimization of the parameterized likelihood function. The proposed method is further compared with EKF based approach. Several case studies show a clear benefit using UKF instead of EKF based approach for a class of nonlinear identification in terms of precision and fast convergence.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15217085,"openaccessinfo":{"externalids":{"MAG":"1987596683","ACL":null,"DOI":"10.1109\/CCA.2010.5611170","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cerebrospinal fluid may provide indicators of age-associated decline in brain function [Also see Report by Baruch et al.] The human brain exists in a unique environment, shielded from the blood and conditioned by its own remarkably active metabolism, yet dependent on the blood-brain interface to import nutrients and remove waste. Age-related decline in brain function is almost certainly caused by multiplexed pathways that incorporate intrinsic brain failure, worsening systemic environment, and accumulation of toxic metabolic waste. If we could identify and monitor alterations in an organ that reflects the determinants of age-associated decline, we might better understand how these changes arise and perhaps even counteract them. On page 89 in this issue, Baruch et al. (1) have done just that. They studied gene expression in a series of organs from young and old mice. The authors propose that the choroid plexus\u2014a specialized structure lying deep within the brain\u2014may provide a readout of the brain's overall status and may potentially mediate some facets of debility during aging.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":206562401,"openaccessinfo":{"externalids":{"MAG":"2080648334","ACL":null,"DOI":"10.1126\/science.1260705","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The use of human neural progenitor cells (hNPC) has been proposed to provide neuronal replacement or astrocytes delivering growth factors for brain disorders such as Parkinson's and Huntington's disease. Success in such studies likely requires migration from the site of transplantation and integration into host tissue in the face of ongoing damage. In the current study, hNPC modified to release glial cell line-derived neurotrophic factor (hNPCGDNF) were transplanted into either intact or lesioned animals. GDNF release itself had no effect on the survival, migration, or differentiation of the cells. The most robust migration and survival was found using a direct lesion of striatum (Huntington's model) with indirect lesions of the dopamine system (Parkinson's model) or intact animals showing successively less migration and survival. No lesion affected differentiation patterns. We conclude that the type of brain injury dictates migration and integration of hNPC, which has important consequences when considering transplantation of these cells as a therapy for neurodegenerative diseases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":19531894,"openaccessinfo":{"externalids":{"MAG":"2039779463","ACL":null,"DOI":"10.3727\/096368908786516819","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc2650839?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In the past decades, embedded system designers moved from simple, predictable system designs towards complex systems equipped with caches, branch prediction units and speculative execution. This step was necessary in order to fulfill increasing requirements on computational power. Static analysis techniques considering such speculative units had to be developed to allow the estimation of an upper bound of the execution time of a program. This bound is called worst-case execution time (WCET). Its knowledge is crucial to verify whether hard real-time systems satisfy their timing constraints, and the WCET is a key parameter for the design of embedded systems. In this paper, we propose a WCET-driven branch prediction aware optimization which reorders basic blocks of a function in order to reduce the amount of jump instructions and mispredicted branches. We employed a genetic algorithm which rearranges basic blocks in order to decrease the WCET of a program. This enables a first estimation of the possible optimization potential at the cost of high optimization runtimes. To avoid time consuming repetitive WCET analyses, we developed a new algorithm employing integer-linear programming (ILP). The ILP models the worst-case execution path (WCEP) of a program and takes branch prediction effects into account. This algorithm enables short optimization runtimes at slightly decreased optimization results. In a case study, the genetic algorithm is able to reduce the benchmarks' WCET by up to 24.7% whereas our ILP-based approach is able to decrease the WCET by up to 20.0%.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":10638415,"openaccessinfo":{"externalids":{"MAG":"2059894640","ACL":null,"DOI":"10.1145\/2038698.2038724","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/ls12-www.cs.tu-dortmund.de\/daes\/media\/documents\/publications\/downloads\/2011-cases_2.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper analyzes the function of historiography in the formation of religious identity in Late Antique Iran. The main focus will be the models of Church-State relation generated by the East-syriac historiography of the Fifth and Sixth Centuries. First we will concentrate in the different ways in which the modern Historians characterized the place of the Church in the Sasanian religious and political Order. Secondly, we will consider some models of kingship produced by the Christian Historians of the Sasanian Empire. These models, far from expressing the actual marginality of the Christian community, revealed the tensions generated by the building of religious barriers (Christina\/pagan, Orthodox\/Heretic) in a World characterized by ambiguity. To sum up, these models were ways of representing specifically Christian pattern of authority and identity related to the particular conditions of the Iranian Society.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":155247666,"openaccessinfo":{"externalids":{"MAG":"2188602416","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With this last instalment, Professor Pace brings to a close his monumental survey of ancient Sicily. In the preceding volume (see JRS XLI (1951), 179-181) P. had passed in review the brilliant and many-sided contribution made by the island to the civilization of the Graeco-Roman world. The entry of two new factors\u2014Christianity and the barbarian invaders\u2014forms the background of the present work, which includes also the period of Byzantine occupation down to the Moslem conquest of the ninth century. Only at this point, in P.'s view, can we place the beginning of the Middle Ages. Sicily is in fact the locus classicus proving the correctness of Pirenne's contention (p. 461), since neither the new faith, nor the interlude of Ostrogothic rule, nor even the final phase of Byzantine administration, with its alien interests and outlook, sufficed to shatter the antique mould of Sicilian life and thought, fixed as it was in definitive form at the height of the Roman Empire. To this one might answer that Sicily's experience can hardly be regarded as typical of the West. The strategic and economic importance of the island secured for it exceptional treatment from both Odoacer and Theodoric, which was continued in some respects by Justinian. Saved by its geographical position from Lombard raids or Frankish interference, Sicily was further separated from the peninsula when its church was transferred to the jurisdiction of Constantinople; and when the Islamic forces advanced into North Africa, another link with the outer world was severed which, as P. shows, had been of fundamental importance in its earlier history. Such isolation goes far to explain the continued survival of classical culture, and to reduce its significance in the context of Western development as a whole. No brief summary could do justice to the rich contents of this volume, which illustrates with a wealth of documentary and archaeological material, interspersed with penetrating comment and generalization, the beginnings of Christianity on the island and the varied achievements of the last five centuries of ancient Sicily. In accordance with P.'s general scheme, the arrangement\u2014which incidentally involves some overlapping\u2014is in part chronological, but principally under subjects (architecture, literature, etc.) ; occasionally, as in the peripatetic survey of Byzantine remains, a purely topographical method is followed. In this latter connection, P.'s treatment of wall-paintings assignable to the obscure pre-Islamic period (pp. 389 ff.) may be thought a little disappointing. Future editions will no doubt be able to incorporate the results of research, too recent to be used here, in the field opened up by Orsi's invaluable pioneering. It remains only to congratulate the author on the conclusion of a notable task which only he could have undertaken. Merely as a work of reference to the vast accumulation of specialized literature on Sicilian problems his four massive volumes will be indispensable. But they are no mere catalogue. P.'s conviction of the continuing individuality of Sicilian culture gives unity and perspective to his detailed panorama ; the whole is suffused with a warmth of feeling and a balanced enthusiasm which must command the sympathy of all lovers of his beautiful island.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":163729397,"openaccessinfo":{"externalids":{"MAG":"2334485974","ACL":null,"DOI":"10.2307\/297528","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The aim of this research is to find out what's attitude Swedish consumers have to Chinese food. The questionnaires based on the Food Choice Questionnaire (FCQ) are handed out to 100 Swedish respondents in order to investigate their motivation on Chinese food choice. 78 questionnaires which were filled completely were selected for this study. Eleven factors involved in the questionnaire are labeled health, mood, convenience, sensory appeal, natural content, price, weight control, familiarity, image of China, culture and safety. The information from two semi-structured interviews with Chinese food suppliers showed Swedish consumers' attitude to Chinese food in another angles. The ABC model and Balance Theory are seen as the theoretical basis for empirical research analysis. The eating habits of Swedish and Chinese are compared to show their difference which influence consumers on food choice more or less. According to the result of the questionnaire survey, Swedish consumers have positive attitude to Chinese food on factors of health, sensory appeal, natural content, safety, price and mood and relative negative attitude on factors of convenience, familiarity and image of China. This outcome is confirmed by the information collected from interviews. Most Swedish consumers choose Chinese food from information processing perspectives; few of them are from behavioral learning processing; some of them are from hedonic consumption perspective. The relationship among Swedes, Chinese food and China is unstable at present time. Swedes do not know much about China and they are not familiar with Chinese food either. Competitors of Chinese food in Sweden such as Thai food, Japanese sushi and west fast food are important aspects which disperse people's attention and enlarge their food choice range.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":141983654,"openaccessinfo":{"externalids":{"MAG":"403707940","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Phase separation process is influenced by operational factors that can hardly be controlled. This paper demonstrates the results of a series of experiments aiming to solve these problems using polyvinyl-alcohol - poly-acrylic acid copolymer hydrogel micro-carrier for the adherence of microorganisms to achieve better settling properties of the biomass. The nitrification process was examined using hydrogel micro-carriers and conventional activated sludge flocks. The sedimentation properties of the two systems were compared indifferent conditions. Results show that the sedimentation properties of the immobilized system were more favorable than activated sludge flocks.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":117557947,"openaccessinfo":{"externalids":{"MAG":"2734348880","ACL":null,"DOI":"10.1556\/606.2017.12.2.8","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/real.mtak.hu\/56265\/1\/606.2017.12.2.8.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"At Echassieres (Allier, France), arsenic speciation was determined in a soil developed over a micaschist where Hercynian hydrothermal mineralization, including arsenopyrite FeAsS and lollingite FeAs2, has lead to a regional As anomaly. The overlying soils which have developed from long term weathering exhibit As levels as high as 900 ppm in the richest area, where the saprolite contains up to 5200 ppm As. Analysis by powder XRD, [nu]-X-ray diffraction on the 20[nu]m scale, SEM-EDS and electron micro-probe analyses revealed that As, released from arsenopyrite and\/or lollingite alteration, is concentrated in a secondary iron arsenate, pharmacosiderite, (Bax,K2-2x) (Fe,Al)4 (AsO4)3 (OH)5 \u00b7 6H2O. Quantitative mineralogical analysis by Rietveld refinement indicates that the proportion of As hosted by this mineral decreases systematically from the saprolite to the topsoil (from 70 % to 30 % of the total bulk As content, respectively). EXAFS spectroscopy indicates that the main form of the As occurring with pharmacosiderite, consists of As(V) ions sorbed on iron oxides. Sorption processes, which dominate As speciation in the topsoil horizons, appear as a key mechanism able to delay As dissemination from soils to plant and surface waters, provided that pH and Eh conditions remain sufficiently acidic and oxidizing, respectively.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":54948919,"openaccessinfo":{"externalids":{"MAG":"2122833781","ACL":null,"DOI":"10.2113\/173.3.281","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/documents.irevues.inist.fr\/bitstream\/2042\/205\/1\/10.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Objective Security companies collect million of malware samples every day. This big-data aspect is a new concept in malware analysis but it is certainly here to stay. On top of traditional samples, the upcoming Internet of Things (IoT) revolution will inevitably increase both the amount and the diversity of the collected artifacts. However, despite its promises, big data collection has so far brought to our field more challenges than advantages \u2013 mainly resulting in a burden for researchers and malware analysts. In fact, on the one hand more samples mean less time to analyze them and larger infrastructures required to store the files and execute them in dynamic analysis sandboxes. On the other hand, security companies are clearly struggling to sift through this increasing amount of data in the attempt to extract some actionable intelligence to better protect their customers and improve their services. As a result, while there is a clear global trend towards collecting more and more data, most of this data is just sitting unused on some server, taking terabytes of storage space without actually being used, exploited, and often even properly understood by the company that collect it. On top of this poor understanding of big malware dataset, new advanced techniques are making the analysis of individual samples more complex and more time-consuming. For instance, ROP-only malware, disk-less samples, and advanced obfuscations are reducing our ability to automatically process and understand new malicious files. The goal of this thesis is to harness the information stored in large malware datasets to improve the samples analysis, provide intelligence information, detect correlation, or simply study trends and evolution of different techniques used by malware writers. In this challenging context, this dissertation will also explore new techniques to extend current static and dynamic analysis approaches to the analysis of novel and sophisticated malware samples. This can involve heavily obfuscated and packed binaries or new form of malicious code and will rely on existing large-scale malware collection systems to provide the required data to conduct experiments.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":201112672,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objectives To examine the association between self-reported eating rate and metabolic syndrome. Design Cross-sectional study. Setting Annual health checkup at a health check service centre in Japan. Participants A total of 56\u2005865 participants (41\u2005820 male and 15\u2005045 female) who attended a health checkup in 2011 and reported no history of coronary heart disease or stroke. Main outcome measure Metabolic syndrome was defined by the joint of interim statement of the International Diabetes Federation and the American Heart Association\/National Heart, Lung, and Blood Institute. Results In multiple logistic regression models, eating rate was significantly and positively associated with metabolic syndrome. The multivariable-adjusted ORs (95% CI) for slow, normal and fast were 0.70 (0.62 to 0.79), 1.00 (reference) and 1.61 (1.53 to 1.70), respectively, in men (p for trend <0.001), and 0.74 (0.60 to 0.91), 1.00 (reference) and 1.27 (1.13 to 1.43), respectively, in women (p for trend <0.001). Of metabolic syndrome components, abdominal obesity showed the strongest association with eating rate. The associations of eating rate and metabolic syndrome and its components were largely attenuated after further adjustment for body mass index; however, the association of slow eating with lower odds of high blood pressure (men and women) and hyperglycaemia (men) and that of fast eating with higher odds of lipid abnormality (men) remained statistically significant. Conclusions Results suggest that eating rate is associated with the presence of metabolic syndrome and that this association is largely accounted for by the difference in body mass according to eating rate.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":6365631,"openaccessinfo":{"externalids":{"MAG":"2169839145","ACL":null,"DOI":"10.1136\/bmjopen-2014-005241","PubMedCentral":"4158192","ArXiv":null},"license":"CCBY","url":"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/4\/9\/e005241.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"We have developed and tested a novel functionalised nanocarrier for chlorhexidine (CHX) which provides a very strong enhancement of its antimicrobial action. The nanocarrier was based on lightly-cross-linked acrylate copolymer nanogel particles loaded with CHX followed by a surface functionalisation with the cationic polyelectrolyte poly(diallyldimethylammonium chloride) (PDAC). We explored the antimicrobial effect of the PDAC-coated CHX-loaded nanogel carriers on E. coli, S. auresus, C. cerevisiae and C. reinhardtii and discovered that it is much higher than that of solution with equivalent overall concentration of free CHX. Our experiments also showed a marked increase of the cationic CHX-loaded nanocarriers antimicrobial action on these microorganisms at shorter incubation times compared with the non-coated CHX-loaded nanogel particles at the same CHX concentration and other conditions. We attribute the increase in the antimicrobial activity of the cationically-functionalised nanogel carrier to its electrostatic adhesion to the microbial cells walls which allows much higher CHX concentration to be delivered directly onto the cell surface. The results of this study can be used for development of novel more efficient antialgal, antifungal and antibacterial formulations based on cationically functionalised nanogels. Our method can also be used for boosting the effect of other cationic antimicrobial agents by encapsulating them in cationically-functionalised nanogel carriers. This nanotechnological approach could potentially lead to developing more effective antimicrobial and disinfecting agents, dental formulations for plaque control, wound dressings, antialgal\/antibiofouling formulations and novel antifungal agents.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":104746298,"openaccessinfo":{"externalids":{"MAG":"2892329275","ACL":null,"DOI":"10.1039\/C8QM00343B","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mutations in keratin genes underlie a variety of epidermal and nonepidermal cell\u2010fragility disorders, and are the genetic basis of many inherited palmoplantar keratodermas (PPKs). Epidermolytic PPK (EPPK) is an autosomal dominant disorder that can be due to mutations in the keratin 1 gene, KRT1. Epidermolytic ichthyosis (EI), the major keratinopathic ichthyosis, is characterized by congenital erythroderma, blistering and erosions of the skin. Causative mutations in KRT1 and KRT10 have been described, with PPK being present primarily in association with the former. We report four unrelated cases (one with sporadic EI and three with autosomal dominant PPK), due to two novel and two recurrent KRT1 mutations. Mutations in KRT1 are not only scattered throughout the keratin 1 protein, as opposed to being clustered, but can result in a range of phenotypes as further confirmed by these mutations, giving a complex genotype\/phenotype pattern.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":52919357,"openaccessinfo":{"externalids":{"MAG":"2894970802","ACL":null,"DOI":"10.1111\/ced.13800","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/discovery.dundee.ac.uk\/files\/52625625\/Clinical_Exp_Derm_2018_1_.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"High precision packaging equipments need high precision isolator to reduce the vibration transmission from outside to work stage. Nowadays, a useful and effective way for vibration isolating is to employ the proper mounting systems to reduce the vibration. One useful method for helping the design engineer to develop more effective mounting systems is through optimization techniques. Sequential Quadratic Programming (SQP) is an effective optimization technique in many engineering fields. In this paper, design optimization of work stage mounting system based on SQP method for vibration control is presented. The optimization objective is to find the highest decoupling ratio of the each mount while selecting the stiffness and orientations of individual mount. The constraints are imposed to keep the desired decoupled ratio in each orientation and the frequency corresponding to the decoupled ratio. A case study is given to validate the proposed method. The result shows that the value of optimized system, such as decoupling ratio, is improved significantly. Therefore, the method proposed in this paper is effective for the optimization of work stage mounting system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":12585265,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors present a case of abdominal actinomycosis in a 65-year old woman undergoing explorative laparatomy for suspected colic neoplasm. Only histological examination allowed a correct diagnosis to be made, showing once again the considerable difficulty of differential diagnosis.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":32361125,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Simple Summary Multiple genetic mutations are associated with the outcomes of patients with non-small cell lung cancer (NSCLC) after using tyrosine kinase inhibitor, but the cost for detecting multiple genetic mutations is high. Few studies have investigated whether multiple genetic mutations can be simultaneously detected based on image features in patients with NSCLC. We developed a machine learning-derived radiomics approach that can simultaneously discriminate the presence of EGFR, KRAS, ERBB2, and TP53 mutations on CT images in patients with NSCLC. These findings suggest that machine learning-derived radiomics may become a noninvasive and low-cost method to screen for multiple genetic mutations in patients with NSCLC before using next-generation sequencing tests, which can help to improve individualized targeted therapies. Abstract Purpose: To develop a machine learning-derived radiomics approach to simultaneously discriminate epidermal growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene (KRAS), Erb-B2 receptor tyrosine kinase 2 (ERBB2), and tumor protein 53 (TP53) genetic mutations in patients with non-small cell lung cancer (NSCLC). Methods: This study included consecutive patients from April 2018 to June 2020 who had histologically confirmed NSCLC, and underwent pre-surgical contrast-enhanced CT and post-surgical next-generation sequencing (NGS) tests to determine the presence of EGFR, KRAS, ERBB2, and TP53 mutations. A dedicated radiomics analysis package extracted 1672 radiomic features in three dimensions. Discriminative models were established using the least absolute shrinkage and selection operator to determine the presence of EGFR, KRAS, ERBB2, and TP53 mutations, based on radiomic features and relevant clinical factors. Results: In 134 patients (63.6 \u00b1 8.9 years), the 20 most relevant radiomic features (13 for KRAS) to mutations were selected to construct models. The areas under the curve (AUCs) of the combined model (radiomic features and relevant clinical factors) for discriminating EGFR, KRAS, ERBB2, and TP53 mutations were 0.78 (95% CI: 0.70\u20130.86), 0.81 (0.69\u20130.93), 0.87 (0.78\u20130.95), and 0.84 (0.78\u20130.91), respectively. In particular, the specificity to exclude EGFR mutations was 0.96 (0.87\u20130.99). The sensitivity to determine KRAS, ERBB2, and TP53 mutations ranged from 0.82 (0.69\u201390) to 0.92 (0.62\u20130.99). Conclusions: Machine learning-derived 3D radiomics can simultaneously discriminate the presence of EGFR, KRAS, ERBB2, and TP53 mutations in patients with NSCLC. This noninvasive and low-cost approach may be helpful in screening patients before invasive sampling and NGS testing.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":233395577,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3390\/cancers13081814","PubMedCentral":"8070114","ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/2072-6694\/13\/8\/1814\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"The 2008 edition of the International Conference on Many Particle Spectroscopy of Atoms, Molecules, Clusters and Surfaces was held in Paris from 30 June to 2 July 2008. This biennial conference alternates with the International Symposium on (e,2e), Double Photoionization and Related Topics which is a satellite of the International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC) conference. Over 110 participants from 20 countries gathered to examine the latest developments in the field of radiation interactions with matter. These include electron\u2013electron correlation effects in excitation and in single and multiple ionization of atoms, molecules, clusters and surfaces with various projectiles: electrons, photons and ions. The present proceedings gathers the contributions of invited speakers and is intended to provide a detailed state-of-the-art account of the various facets of the field. Special thanks are due to Universite Paris Sud XI, CNRS, and the laboratories LCAM, LIXAM and LCPMR which provided financial support for the organization of the conference. We are also grateful to the contribution of the companies Varian and RoentDek Handels GmbH. Guest Editors: Danielle Dowek and Azzedine Bennani LCAM, Universite Paris Sud XI, France Pascal Lablanquie and Alfred Maquet LCPMR, Universite Pierre et Marie Curie, Paris, France INTERNATIONAL SCIENTIFIC COMMITTEE Lorenzo Avaldi, (Italy) Alexei Grum Grzhimailo, (Russia) Klaus Bartschat, (USA) Nikolai Kabachnik, (Russia) Jamal Berakdar, (Germany) Birgit Lohmann, (Australia) Nora Berrah, (USA) Don H Madison, (USA) Michael Brunger, (Australia) Francis Penent, (France) Albert Crowe, (UK) Bernard Piraux, (Belgium) Claude Dal Cappello, (France) Roberto Rivarola, (Argentina) JingKang Deng, (China) Emma Sokkel, (Ireland) Alexander Dorn, (Germany) Giovanni Stefani, (Italy) Reinhardt Dorner, (Germany) Noboru Watanabe, (Japan) Francois Fremont, (France) LOCAL ORGANIZING COMMITTEE Azzedine BENNANI (Chair) - Universite Paris-Sud 11, Orsay Danielle DOWEK (co-Chair) - Universite Paris-Sud 11, Orsay Bernadette ROME (Secretary) - Universite Paris-Sud 11, Orsay Elena Magdalena STAICU CASAGRANDE - Universite Paris-Sud 11, Orsay Alain HUETZ - Universite Paris-Sud 11, Orsay Laurence MALEGAT - Universite Paris-Sud 11, Orsay Michael MEYER - Universite Paris-Sud 11, Orsay Adnan NAJA - Universite Paris-Sud 11, Orsay Yan PICARD - Universite Paris-Sud 11, Orsay Lidija ANDRIC - Universite Pierre et Marie Curie, Paris Alain DUBOIS - Universite Pierre et Marie Curie, Paris Pascal LABLANQUIE - Universite Pierre et Marie Curie, Paris Alfred MAQUET - Universite Pierre et Marie Curie, Paris Francis PENENT - Universite Pierre et Marie Curie, Paris Patricia SELLES - Universite Pierre et Marie Curie, Paris Marc SIMON - Universite Pierre et Marie Curie, Paris","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":162242041,"openaccessinfo":{"externalids":{"MAG":"2042107449","ACL":null,"DOI":"10.1088\/1742-6596\/141\/1\/011001","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/141\/1\/011001","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Communications Research Laboratory (CRL) established a new generation mobile network project within its Yokosuka Research Radio Communication Research Center in Yokosuka Research Park (YRP) April 1st, 2002, and has been doing research and development of new technologies to enable seamless and secure integration of various wireless access networks such as existing cellular networks, wireless LANs, home networks as well as 4G cellular networks and intelligent transport systems (ITS). This four-year-long project covers wireless security platform technology, media handover technology and wireless access technology. All the developed technologies will compose a single test-bed in the final stage for demonstrating and evaluating new functions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":60839446,"openaccessinfo":{"externalids":{"MAG":"1593401128","ACL":null,"DOI":"10.1109\/ICCT.2003.1208996","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Multiconcomitant therapy using adriamycin, cyclophosphamide, tegafur and tamoxifen was employed as chemo-endocrine therapy against progressive breast cancer, and the effects, toxicity and prognosis associated with this regimen were studied. This therapy was performed in 24 cases of both inoperable progressive breast cancer and postoperatively recurrent breast cancer. Efficacy was noted in 14 cases, including 4 cases of complete remission, giving an efficacy rate of 58%. Ten patients among the total of 24 are presently alive. The median survival time for all cases was 19.5 months, versus 34.0 months for effective cases and 12.5 months for ineffective cases. The main side effects noted were hematological toxicity, gastrointestinal symptoms and alopecia, but none of these symptoms were serious. Symptoms of heart failure occurred in one patient due to cardiotoxicity of adriamycin, but were not fatal. It can be concluded that ACFT therapy for the treatment of progressive breast cancer results in a good efficacy rate and longer survival time.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37432750,"openaccessinfo":{"externalids":{"MAG":"2396590854","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents early lessons from the development of SPOK, an End-User Development Environment for smart homes. SPOK (Simple PrOgramming Kit) uses a pseudo-natural language as an end-user programming language and runs on top of an extension of OSGi\/iPOJO to support the dynamic and resilient management of web services and devices from a variety of protocols including EnOcean, UPnP, and Watteco. The motivation for SPOK is to give the power back to end-users so that they can shape their own smart home at will. This paper reports lessons learned from the methods we have used to validate our hypotheses as well as a number of technical issues concerning development of this type of EUDE. A Video of SPOK in action as of October 2013 is accessible at: http:\/\/iihm.imag.fr\/demos\/appsgate\/appsgate2013.mp4","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":8296913,"openaccessinfo":{"externalids":{"MAG":"2064479749","ACL":null,"DOI":"10.1145\/2638728.2641559","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/hal.archives-ouvertes.fr\/hal-01492556\/file\/SPOK-HomeSys2014-Ubicomp.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"The increasing importance of rating agencies as organizations specialized on credit evaluation demonstrates that a global financial economy also produces globally oriented organizations which reflexively contribute to the concentration of financial decisions. Furthermore, the use of such ratings in contexts of legal control seems to emphasize the significance of mixed public-private forms of regulation which make use of market actors' expertise and intimate knowledge of problems. Shedding light on both aspects, the article examines the role of rating agencies in the regulation of global financial markets. Using concepts developed in risk sociology and sociology of knowledge it shows that, on the one hand, rating agencies indeed contribute to the handling of economic risks by constructing virtual worlds which stabilize expectations, while, on the other hand, in fulfilling their manifest function, they also produce new contingencies and uncertainties. Rating agencies improve the capacity for managing complexity of the self-referentially operating financial markets; but that is the very reason why they follow the logic of a functionally differentiated society tending towards an increase in options and contribute to the further growth of ignorance and the riskiness of financial markets. As to \"regulation by rating\" it is obvious that while the use of ratings expands the internal complexity of the regulatory regime, it inevitably produces new problems as well.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":142137545,"openaccessinfo":{"externalids":{"MAG":"765718016","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A convenient and highly efficient synthesis of indenamines has been developed via ruthenium-catalyzed [3+2] carbocyclization under very mild conditions. A catalyst system of Ru(II) \u03c0-allyl precursor and N-heterocyclic carbene (NHC) ligand promotes facile coupling between aromatic N\u2013H ketimines with internal alkynes at mild temperatures, without added oxidants or other metal salts, and in non-polar solvents. A proposed mechanism involves imine-directed activation of aromatic C\u2013H bond, alkyne insertion, and carbocyclization by intramolecular imine insertion into Ru\u2013alkenyl linkages.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":7529101,"openaccessinfo":{"externalids":{"MAG":"2952270447","ACL":null,"DOI":"10.1002\/anie.201209031","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc4310470?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In a study evaluating a medical diagnostic test, human samples are valuable and often costly, therefore prime concerns require termination of the study if the test is evidently inefficient (or efficient) in diagnosis of diseases in order to keep the number of samples as low as possible. In this paper, we propose sequential designs to evaluate the sensitivity and specificity of a diagnostic test. One method allows early stopping if the sensitivity and specificity of a new medical test are both within the level of tolerance. Another method terminates the study if either the sensitivity or the specificity is below the minimally acceptable level. The latter method minimizes the expected sample size when the test does not meet expectations on performance, and illustrates substantial advantage of having smaller expected sample sizes in various two\u2010stage designs compared to the sample sizes of single\u2010stage designs when a diagnostic test is not promising. Published in 2007 by John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20689923,"openaccessinfo":{"externalids":{"MAG":"2009967760","ACL":null,"DOI":"10.1002\/sim.2881","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The design and operating experience of the Selective Catalytic Reduction (SCR) systems for denitrification of flue gas in utility and industrial gas turbine applications is presented. The paper will discuss the general SCR design approaches and the effects on the NOx removal efficiency of various design and operating parameters such as gas temperature, velocity and composition, NOx content, catalyst material and type, quantity of ammonia injected, aging, and pressure drop limitation. Two different types of ammonia injection methods (namely, anhydrous and aqueous ammonia injections) and attendant ammonia injection control schemes are described. A brief summary of SCR operating experience with power-generating gas turbines and process heaters\/boilers concludes the paper.Copyright \u00a9 1991 by ASME","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":94985034,"openaccessinfo":{"externalids":{"MAG":"1991813247","ACL":null,"DOI":"10.1115\/91-GT-026","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The structural properties of polycrystalline yttria-stabilized zirconia (YSZ) have been studied using FT-Raman spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy (XPS). Yttria content was varied between 8 and 15% (by mole fraction) to determine compositional effects on YSZ phonon structure, lattice parameter, and oxidation state. The dominant feature in the low-frequency Raman spectrum correlates quite closely with the material's sole (cubic) lattice parameter. XPS measurements of typical YSZ samples show only a single species of both Y and Zr. After exposing YSZ to a reducing environment (H2) at elevated temperatures (1000 degrees C), however, the XPS spectra of YSZ show new features at lower binding energy for both Y and Zr. Angle-resolved XPS measurements suggest that these reduced forms of Y and Zr exist only within the first few molecular layers of the sample. This treatment does not effect the XRD pattern, nor does it change the low-frequency phonon structure observed in the Raman spectrum, although the Raman spectrum does experience approximately 50% reduction in overall signal intensity. These disparities are reconciled with each other based on differences in each technique's sampling depth. The impact that surface-reduced YSZ may have on the chemistry occurring within solid oxide fuel cells is discussed briefly.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20854715,"openaccessinfo":{"externalids":{"MAG":"2044300473","ACL":null,"DOI":"10.1021\/AC048600U","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"5G is seen as one technology enabler to support the expected exponential internet data-traffic growth while digitization environmental impacts are growing. Base stations are estimated to represent the main contributor to mobile internet access network carbon footprint. In this work, life cycle assessment (LCA) of a 26 GHz transmitarray antenna is described taking into consideration the geographical location of the antenna use and providing eco-design leads to researchers, designers, LCA practitioners and industrials. Results show that energy consumption during operation is the main source of impact (between 72% and 94% for most impacts), while the material depletion is largely generated by the manufacturing process (99.3%). As a result, the eco-design must focus on product energy efficiency as well as material depletion during manufacturing. The impact of usage is highly dependent on the location due to the diverse electricity mix of countries. An eco-design solution using phase-change material (PCM) technology switches is compared to a conventional approach using GaAs p-in diodes. These results pave the way for reducing the impacts of transmitarray antennas and are a first step towards more sustainable solutions for millimeter wave (mmWave) networks.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":3}},"corpusid":250392673,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/eucnc\/6gsummit54941.2022.9815659","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/cea.hal.science\/cea-03837030\/file\/1570787807%20final.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This article analyzes the spectral structure of hydrogen atoms according to the motion theory of elastic particles. The results demonstrate that optical radiation originates from the elastic vibration of atoms or molecules. The quantum state is the equilibrium feature of the classically statistical system, and the quantum transition is the process of conversion between different motion modes.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":211164853,"openaccessinfo":{"externalids":{"MAG":"2991393595","ACL":null,"DOI":"10.34257\/gjsfrfvol19is4pg19","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.34257\/gjsfrfvol19is4pg19","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"On this study, usage possibility of the dried Porphyridium cruentum type microalga biomass in the chewing gum formulation as a natural colorant was investigated. For this aim, the effect of different spray dryer inlet temperatures (150-200 \u00b0C) on pigment (total carotenoid and chlorophyll-a) quantities and color properties ( L*, a*, b* and C* ) of Porphyridium cruentum type microalga biomass were examined. P. cruentum were cultured using the tubular photobioreactor and harvested by centrifugation. The dried microalga was then added to chewing gum at different concentrations (0.5% and 1.0% wI:w) as a natural red colorant. The amount of the total carotenoids in dried biomass ranged from 112.6 to 419.9 \u03bcg g -1 and chlorophyll-a from 511 to 1513 \u03bcg g -1 . Considering sensorial analysis, algal taste increased with increasing microalga concentration ( p < 0.05). The studied factors had no significant effect on cohesiveness, (0.186-0.254), springiness (0.713-0.806) and resilience (0.014-0.015) parameters in chewing gums ( p < 0.05). However, a* value in chewing gum samples increased with drying temperature and usage amount (from 10.5 to 18.7) which increased red color intensity. According to the findings of the present study, it can be concluded that P. cruentum biomass had a potential use in chewing gum matrix.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":102863854,"openaccessinfo":{"externalids":{"MAG":"2806430243","ACL":null,"DOI":"10.1590\/FST.41817","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we describe a combined approach where low density parity check (LDPC) codes are used to reduce the complexity and power consumption of pulsed orthogonal frequency-division multiplexing (pulsed-OFDM) ultra-wideband (UWB) systems. The proposed system will use LDPC codes to achieve higher code rates without using convolution encoding and puncturing thereby reducing the complexity and power consumption of pulsed-OFDM system. The LDPC-pulsed-OFDM system will achieve channel capacity with different code rates and will have good performance in different channel fading scenarios. The proposals from pulsed OFDM system is used where pulsed signals could spread the frequency spectrum of the OFDM signal. The performance of LDPC-pulsed-OFDM system for wireless personal area networks (WPAN) is analysed for different UWB indoor propagation channels (CM3 and CM4) provided by the IEEE 802.15.3a Standard activity committee. To establish this, we present a design of LDPC-pulsed-OFDM system using the digital video broadcasting-satellite-second generation (DVB-S2) standard and provide the simulation results for the different code rates supported by LDPC codes.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":62600864,"openaccessinfo":{"externalids":{"MAG":"2053919409","ACL":null,"DOI":"10.1504\/IJICA.2012.045704","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Froude-supercritical bedforms and associated sedimentary structures are formed in turbulent flows when value of the Froude Number is Fr greater than 1. They have been increasingly studied in recent years, and while they were previously considered to be of rare preservation, they have been increasingly identified in modern settings and the rock record. In alluvial systems, these structures are being recognized as characteristic of rivers with high variability of discharge, especially in arid, semiarid and subhumid tropical and subtropical climates. However, the development of facies models for such rivers remains tentative, particularly for the rock record, and with the exception of Australia, examples in Gondwana are scarce. The Early Triassic Sanga do Cabral Formation represents an arid to semiarid ephemeral fluvial system cropping out in Southern Brazil, Southwestern Gondwana. The present study reinterprets the sedimentary structures within this formation as Froude-supercritical structures, and ident ifies three Fluvial Styles (FS). FS1 predominantly consists of fine-grained massive sandstone, with interruptions of intraclastic conglomerates, and occasionally-visible faint lamination and mud intraclast levels. It is interpreted as deposited by unconfined flows in the distal portion of a fluvial system, generating hyperconcentrated flows which resulted in thin beds of fine-grained sandstone with massive structure or plane-parallel lamination, and incipient antidunes. FS2 was deposited by flash floods occurring repeatedly within a short period during a wet season. This resulted in a fining-upwards succession of intraclastic conglomerates with supercritical-flow structures, through sandstones with supercritical-flow structures, to sigmoidal cross-stratification and ripple marks with diffuse lamination. FS3 was deposited by catastrophic flash floods characterized by high discharge and flow velocity, possibly generated by erratic storms, which poured in single events. These catastrophic flows generated lar ge-scale sandy antidunes and other Froude-supercritical bedforms with mud intraclasts, which deposited sandstone in undulating laminae, and other supercritical-flow structures. These floods waned extremely rapidly, bypassing the stability field of lower-flow regime bedforms. Measurements taken from undulating stratification, interpreted as antidune deposits, allowed for the estimation of paleoflow velocity and depth. The largest antidunes had a maximum estimated wavelength of 28.92 m (with a mean of 15.4 m) and maximum estimated height of 1.42 m (with a mean of 0.85 m), resulting in an estimated paleoflow velocity of up to 6.72 ms-1 (with a mean of 4.9 ms-1) and a maximum flow depth of 1.59 m (with a mean of 0.9 m). These parameters are comparable to those observed in modern fluvial floods. This study reinforces the significance of Froude-supercritical structures in enhancing our understanding of fluvial systems characterized by high variability in discharge, allowing for a finer interpretation of their d ischarge patterns. This approach can be applied to better understand the many arid, semiarid, or strongly seasonal environments of the Early Triassic period in Gondwana, and potentially other regions and geological times.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":262186393,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2110\/jsr.2022.063","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"critical incident involving a disruption of our hospital's bulk oxygen supply. During a construction project a contractor's backhoe ruptured the solitary oxygen supply line to our facility. All the anaesthesia machines' oxygen failure warning devices were activated (10 operating rooms) and all the anaesthetists successfully switched their anaesthesia machines to portable oxygen cylinders without incident. However, in the cardiac surgery suite there were several moments of consternation regarding the heart-lung machine and its oxygen supply. The perfusion team was using a Stockert-Shiley heart-lung machine with a computer-aided perfusion system (CAPS). There were two immediate problems. The first was that while the heart-lung machine had a battery back-up for loss of electrical power, it had no oxygen back-up . The tubing from the air \u2044 oxygen blender to the gas filter oxygenator was cut and the non-sterile end of the gas filter oxygenator tubing was connected to an oxygen cylinder; the oxygen was delivered at 3 l.min. The time from activation of the oxygen warning device to the application of supplemental oxygen to the heart-lung machine was less than 4 min. The second problem was the inability to deliver potent anaesthetic agent to the patient because of the lack of availability of a compressed gas line to the heart-lung machine. This was solved with conversion of the inhaled anaesthetic to total intravenous anaesthesia (using midazolam and sufentanil). The case concluded uneventfully and the patient was discharged from the hospital without incident. There are several lessons to be learned from this experience. Hospitals should prepare for the contingency described above \u2022 by planning back-up systems with physical separation of oxygen feeder lines, as well as a manifold of cylinders tanks [1]; \u2022 by having an oxygen cylinder and appropriate tubing available to replace the heart-lung machine's oxygen source in the event of oxygen failure; \u2022 by performing an anaesthesia machine check before the case begins, including a check of the contingent oxygen cylinders attached to the machine; \u2022 by always paying attention to alarms.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":221390931,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1111\/j.1365-2044.2004.04042.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/j.1365-2044.2004.04042.x","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The frequency of intestinal parasitoses among subjects coming from warm countries is high and its range is similar to that found by other parasitologists in Europe as well as by those who made investigations in groups of individuals in various warm countries. Bearing in mind the pathogenous role--even limited--of certain parasites, their systematic detection and the treatment of every individual infested with parasites appears necessary. The hereby investigations point out the importance of a complex coproparasitologic examination and the high efficiency of some special diagnosis methods. Every laboratory must perform in rarallel several ovoscopic and larvoscopic methods of investigation in view of an accurate parasitologic diagnosis or for a prophylactic control of subjects coming from warm countries. The high frequency of ankylostomiasis raises peculiar problems related to its systematic detection and its compulsory treatment up to the parasitologic sterilization, bearing in mind the past evolution in Rumania of an underground focus, which does not exist any more, having been entirely eradicated.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23169093,"openaccessinfo":{"externalids":{"MAG":"2418931034","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Character education is also important given to autistic children. This phenomenological research aims to reveal the teacher's experience in teaching character education for autistic children. The participants in this research were 10 teachers from three exceptional schools consisting of public and private exceptional schools. In-depth interview method as a data collection technique. Data analysis using semantic reduction is carried out by the stages of identifying important statements from the results of the interview, determining the theme of the discussion, and describing the significance of the whole the teacher's experience. The results found that character learning for autistic children through three models, namely explanatory, practice, and intensive mentoring. The explanatory model is used to practice the ability of autistic children in terms of building children's concentration and focus. The practice model is used to train autistic children soft skills in terms of strengthening the understanding of the material and its reasoning ability. While the intensive mentoring model for training soft skills autistic children related to the ability of interpersonal relationships and confidence. Therefore, the inclusion of teacher competencies must at a minimum include pedagogical, personal, and social abilities to teach character education for autistic children.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":228877472,"openaccessinfo":{"externalids":{"MAG":"3094707627","ACL":null,"DOI":"10.11591\/IJERE.V10I1.20743","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper reports two variable-gain amplifiers (VGAs) featuring a new pseudo-current-steering gain-tuning technique. In the first VGA (VGA-I), a single-voltage-controlled dual-branch current mirror is exploited as a standalone gain control block. In the second VGA (VGA-II), two NMOS transistors, which are biased by a tunable voltage, are integrated into a conventional common-source amplifier to steer away partial of the total current. Fabricated in 40-nm CMOS technology, the VGA-I (VGA-II) occupies a tiny area of 0.03 mm2(0.024 mm2) and consumes 22 mW (20 mW). Measured over a gain range of > 64 dB, the \u22123-dB bandwidth of the VGA-I (VGA-II) is 9 GHz (6.6 GHz). For the time-domain tests, VGA-I (VGA-II) exhibits a jitter of 40 ps (30 ps), under a 27-1 PRBS input at 12 Gb\/s. Their power efficiencies (1.83 and 1.67 pJ\/bit) compare favorably with state-of-the-art wideband VGAs.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":210693030,"openaccessinfo":{"externalids":{"MAG":"2998966149","ACL":null,"DOI":"10.1109\/APCCAS47518.2019.8953084","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"INFANTILEAUTISM The three authors of this book state that it is designed to provide a single integrated text for medical school courses in the neurosciences. This aim has been achieved in a wieldy volume, admirable for the clarity of text, generously supplemented by excellent diagrams and photographic illustrations. Integration is achieved by introducing some relevant clinical data in the early chapters which deal pri manly with basic anatomy, embryology and cytology, and which include illustrations of light and electron micrographs. The clinical aspects are expanded in chapters in which clinical cases illustrate anatomical and func tional aspects of the various systems. The chapters on the anatomy and clinical aspects of the spinal cord, brain stem and cerebral hemispheres are supple mented by problem solving exercises derived from actual case records. An answer sheet is available on request. Similar exercises in problems of cell and nerve physiology are provided. A film strip of sixty two frames supplementing the course and a viewer are also available from the publisher. The prices of these supplementary aids are not stated. Chapter I I is entitled \u2020\u0303\u00bf Microscopic Anatomy of the Brainstem', but deals in fact with the gross topo graphical anatomy of tracts and cranial nerve nuclei in the form of a series of transverse myelin-stained sections and appropriate diagrams and text. Basic neuropathology is covered briefly in the chapters on the clinical considerations of the cerebral hemi spheres. The microphotographs in this section are disappointing, both scant and poorly reproduced. For quick reference the final chapter consists of a short descriptive atlas of the brain and cord. This book, being comprehensive and providing an integrated approach, is recommended for post graduate students of clinical neurology, psychiatry and neurosurgery, as well as for the undergraduate courses for which it is designed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":143685414,"openaccessinfo":{"externalids":{"MAG":"1985150834","ACL":null,"DOI":"10.1192\/bjp.122.1.104","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The population of the Huasteca region is a participant of musical events in different areas, which allows us to recognize that among all genres, Huasteca son highlights and corresponding dance called Huapango are used. These musical forms are imbued with the physical and social environments that live constantly. It is through the lyrics of the Huasteca sones, that the mechanism is developed to reflect the natural world and perceive the events that happen to them, gaining an importance that leads to an identification that transcends. They understand the environment and relate a sense of belonging-ownership, allowing them to recreate their lives and merge into a cultural identification that we call \"regional identity\". The relevance of considering a musical expression of these features is that it preserves and enhances constantly, unifying an area of Mexico that does not correspond necessarily to political boundaries established in different historical periods.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":130322328,"openaccessinfo":{"externalids":{"MAG":"2251508198","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: We here investigated the cause of autoimmunity from different angle, i.e., the defect in immune 'system', and discovered that overstimulation of immune system beyond its self-organized criticality leads to autoimmunity. Results: Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4+ T cells by repeated immunization with antigen led to the development of a fully-matured autoantibody-inducing CD4+ T (aiCD4+ T) cell which had undergone T cell receptor (TCR) revision and was capable of inducing autoantibodies. The aiCD4+ T cell was induced by de novo TCR revision but not by cross-reaction to immunizing antigen, and subsequently overstimulated CD8+ T cells, driving them to become MHC class I-restricted, antigen-specific cytotoxic T lymphocytes (CTL). These CTLs could be further matured by antigen cross-presentation, after which they caused autoimmune tissue injury akin to systemic lupus erythematosus (SLE). Autoimmune tissue injury did not appear in CD8+ T cell-deficient mice. Further, inhibition of antigen-cross presentation by treating with chloroquine abrogated the generation of CTL and autoimmune tissue injury. Conclusion: Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune 'system' by repeated immunization with antigen, to the levels that surpass system's self-organized criticality.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":255687292,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.4049\/jimmunol.184.supp.93.39","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Many decisions made in Software Engineering practices are intertemporal choices: trade-offs in time between closer options with potential short-term benefit and future options with potential long-term benefit. However, how software professionals make intertemporal decisions is not well understood. Aim: This paper investigates how shifting time frames influence preferences in software projects in relation to purposefully selected background factors. Method: We investigate temporal discounting by replicating a questionnaire-based observational study. The replication uses a changed-population and -experimenter design to increase the internal and external validity of the original results. Results: The results of this study confirm the occurrence of temporal discounting in samples of both professional and student participants from different countries and demonstrate strong variance in discounting between study participants. We found that professional experience influenced discounting. Participants with broader professional experience exhibited less discounting than those with narrower experience. Conclusions: The results provide strong empirical support for the relevance and importance of temporal discounting in SE and the urgency of targeted interdisciplinary research to explore the underlying mechanisms and their theoretical and practical implications. The results suggest that technical debt management could be improved by increasing the breadth of experience available for critical decisions with long-term impact. In addition, the present study provides a methodological basis for replicating temporal discounting studies in software engineering.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":195657931,"openaccessinfo":{"externalids":{"MAG":"2963124679","ACL":null,"DOI":"10.1109\/ESEM.2019.8870161","PubMedCentral":null,"ArXiv":"1906.11072"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to explore how perceptions of remembered instances of teacher caring in K-College impacted the motivation of a college student. Implications for teacher preparation programs and educational research were then drawn from these perceptions. The first part of the title \"A Family Affair\" stems from the fact that the authors are members of the same family \u2013 Father, Mother, and Son. Both the father and mother had prior knowledge of some (not all) of the instances of caring and non-caring described by their son and thus shared a privileged insider position that offered unique insights while cooperative peer checking was used both during and after the interview to help promote the trustworthiness of findings. It was found that the degree of caring shown by teachers had a profound influence on the participant's willingness to put forth effort especially in those courses that were not his favorite subjects which suggests that a strong connection exists between caring and student motivation. An important implication of this study is that teachers and those responsible for teacher preparation programs would benefit by being aware of the impact of caring on students' engagement and attitude toward learning. If the ultimate purpose of educational research is to contribute to effective teaching, then the \"soft variable\" of caring should be considered an important component of researcher preparation. It is hoped that readers will find this study to be transferable to the degree that it resonates with their own experience as teachers, students, and parents, and which we refer to as \"experiential validity\".","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":54968050,"openaccessinfo":{"externalids":{"MAG":"2769341511","ACL":null,"DOI":"10.26522\/BROCKED.V26I2.602","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Beam codebooks are a recent feature to enable high dimension multiple-input multiple-output (MIMO) in 5G new radio (NR). Codebooks comprised of customizable beamforming weights can be used to transmit reference signals and aid the channel state information (CSI) acquisition process. In this paper, we characterize the role of each codebook used during the beam management process and design a neural network to find codebooks that improve overall system performance. Evaluating a codebook is not purely about maximizing signal power, but instead, a holistic, system-level view of effective spectral efficiency is necessary to capture the relationships between codebooks, feedback, and spectral efficiency. The proposed algorithm is built on translating codebook and feedback knowledge into a consistent beamspace basis similar to a virtual channel model to generate initial access codebooks and select the subsequent refined beam training. This beamspace codebook algorithm is designed to directly integrate with current 5G beam management standards. Simulation results show that the neural network codebooks improve over traditional codebooks in received signal power, even in dispersive sub-6GHz environments. We further utilize our simulation framework to evaluate type-II CSI feedback formats with regard to effective multi-user spectral efficiency. Our results suggest that optimizing codebook performance can provide valuable spectral efficiency improvements, but 5G feedback quantization resolution limits multi-user performance in sub-6GHz bands due to the rich scattering environment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":257365625,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Statins are lipid-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, the rate-limiting step in cholesterol synthesis. During cholesterol synthesis, isoprenoid intermediates are also formed which prenylate Ras and Rho proteins. Upon prenylation and transportation to the plasma membrane, Ras and Rho may interact with other molecules to partake in a signaling cascade that eventually lead to cell survival and proliferation. When statins inhibit cholesterol synthesis, they also inhibit the formation of these isoprenoid. Our studies focus on the potential anticancer effects of a statin (atorvastatin) in human hepatocellular carcinoma (HepG2) and pancreatic adenocarcinoma (AsPC-1) cells. We hypothesized that atorvastatin enhances cytotoxic effects of cisplatin in HepG2 and AsPC-1 treated cells. By utilizing a cell survival assay and western blot analysis, we found marked differences between the two cell lines after atorvastatin treatment. Our results indicate that treatment with atorvastatin at a concentration range of 0.1 \u00b5M to 20 \u00b5M for 48 and 72 hours significantly decreased cell survival of AsPC-1 cells, but not that of HepG2 cells. The IC50 value for atorvastatin in AsPC-1 treated cells was 3.5 \u00b5M; whereas, no effect on HepG2 cell survival was observed even at 20 \u00b5M concentration. Treatment with atorvastatin in combination with cisplatin in HepG2 cells did not potentiate the decrease in cell survival as compared to cisplatin treatment alone. However, treatment with 10 \u00b5M of atrovastatin in combination with 20 \u00b5M of cisplatin for 72 hours antagonized the effects of cisplatin treatment alone. After 48 hour treatments with atorvastatin, HepG2 and AsPC-1 cells had differential p-ERK expression, which could be an important factor in atorvastatin-induced cell death. Our preliminary findings suggest that statin treatment may be beneficial as a therapeutic avenue for pancreatic cancer but may not have the same benefits for liver cancer. The specific molecular mechanisms that decrease cancer cell survival following statin treatment have not been well understood and needs to be further studied. [Our project is supported by in part from NIH INBRE Grant P20RR016454]. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4403. doi:10.1158\/1538-7445.AM2011-4403","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":76178768,"openaccessinfo":{"externalids":{"MAG":"2332701550","ACL":null,"DOI":"10.1158\/1538-7445.AM2011-4403","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Grade inflation, an upward shift in student grade-point averages without a similar rise in achievement, is considered pervasive by most experts in post-secondary education in the United States. Grade-point averages (GPAs) at US universities have increased by roughly 0.15 points per decade since the 1960s, with a 0.6-point increase since 1967. In medical education, grade inflation has been documented and is particularly evident in the clinical setting. The purpose of this study was to evaluate grade inflation over a 22-year period in a college of veterinary medicine. Academic records from 2,060 students who graduated from the College of Veterinary Medicine at Kansas State University between 1985 and 2006 were evaluated, including cumulative GPAs earned during pre-clinical professional coursework, during clinical rotations, and at graduation. Grade inflation was documented at a rate of approximately 0.2 points per decade at this college of veterinary medicine. The difference in mean final GPA between the minimum (1986) and maximum (2003) years of graduation was 0.47 points. Grade inflation was similar for didactic coursework (years 1-3) and clinical rotations (final year). Demographic shifts, student qualifications, and tuition do not appear to have contributed to grade inflation over time. A change in academic standards and student evaluation of teaching may have contributed to relaxed grading standards, and technology in the classroom may have led to higher (earned) grades as a result of improved student learning.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":43383995,"openaccessinfo":{"externalids":{"MAG":"2099957227","ACL":null,"DOI":"10.3138\/jvme.36.1.107","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/jvme.utpjournals.press\/doi\/pdf\/10.3138\/jvme.36.1.107?download=true","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The upheavals that spread across the Arab world in 2011, leading to the fall of the Tunisian, Egyptian and Libyan republican regimes, have not spared the Gulf monarchies. However, the skewed demographic situation, characterized by high shares of migrant workers, has deeply influenced the protest movements. In the light of the economic and social fallouts of this demographic imbalance), the paper aims to explain the evolving dynamics between rulers and citizens in the Gulf region. Indeed, even though the GCC countries have not experienced radical institutional change, the claims of the protestors have challenged the basis of the current social contract. After having analyzed the most important socio-economic factors shaping the citizenstate relationship, attention will be paid to labour market reforms, which will play an important role in redefining the ruling bargain between citizens and the state and between the state and migrant workers.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":55903209,"openaccessinfo":{"externalids":{"MAG":"2181843161","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although surgical therapy continues to be the gold standard for the treatment of basal cell carcinoma given high cure rates and the ability to histologically confirm tumor clearance, there are a number of nonsurgical treatment options that may be considered based on individual tumor characteristics, functional and cosmetic considerations, patient comorbidities and patient preference. Topical 5-fluorouracil 5% cream and imiquimod 5% cream have been US FDA-approved for the treatment of superficial basal cell carcinoma. Additionally, a number of new and emerging topical agents and techniques have been described for the treatment of basal cell carcinoma and will be reviewed herein.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":235594985,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2217\/fon-2020-1147","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lesbian and gay parenthood is the most adversed topics of the recognition of lesbian and gay families, both from the point of view of the concession of rights and the one of social legitimation. In Italy, the sociological research on the recognition of lesbian and gay families with children is not comparable to the international one. Nevertheless, the development of a political discourse on the rights of lesbian and gay people \u2013 with or without families, with or without children - by European institutions is broadening the interest of Italian sociologists. The article analyses the experiences of 12 gay Italian lesbian and gay parents in order to understand how they negotiate and achieve social legitimation in front of their families of origin, local institutions and neighbours. Results show that lesbian and gay families with children give an important contribution for the pluralization of practices and meanings related to the family. At the same time, they reproduce some crucial features supporting the hegemonic interpretation of the family: the centrality of the couple and the importance of blood ties for the definition of kinship.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":151812596,"openaccessinfo":{"externalids":{"MAG":"2593556313","ACL":null,"DOI":"10.13128\/CAMBIO-19189","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The role of cytochrome P450 monooxygenase in pyrethroid resistance was studied in different strains of the cotton bollworm, Helicoverpa armigera, from India. Filed collected strains of Nagpur and Delhi were compared to the laboratory reared population. The results showed a high resistance to deltamethrin, \u03b1-cypermethrin, and \u03b2-cyfluthrin. The results also showed that this resistance could be reduced by using piperonyl butoxide (PBO). The Nagpur and Delhi strains were found to have a 2.40 and 1.79 fold higher monooxygenase activity compared to a susceptible strain. A strong, positive correlation between monooxygenase activity and pyrethroid resistance was observed (r = 0.86 \u2013 0.98). The relative expression of the housekeeping gene, EF-1\u03b1, and three P450 genes, was studied in the 5th instar larval midgut of the three strains. Out of the three P450 genes examined, expression of CYP6B7 mRNA was not detected in the midgut of the susceptible strain though it was highly expressed in the resistant strains. The midgut of the Nagpur strain had a 2.60 fold overexpression of CYP6B7 mRNA compared to the moderately resistant, Delhi strain. The mRNA of CYP4G8 and CYP6B2 were not overexpressed in either the Nagpur or Delhi strain. The results indicated that the elevated cytochrome P450 monooxygenase activity is associated with pyrethroid resistance in Indian strains of H. armigera, and CYP6B7 could be the P450 form responsible for pyrethroid resistance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":37762870,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present study aimed to review the results of microscopic examination, routine culture and antigen detection by latex particle agglutination test (LPAT), in order to evaluate the diagnostic value of the LPAT in establishing the aetiological diagnosis of bacterial meningitis. LPAT was done in 65 clinically suspected meningitis cases ranging from 5 days to 60 years of age and was compared with culture and Gram stain. Using LPAT, an aetiological diagnosis could be done in 10 out of 65 (15.4%) cases of bacterial meningitis. In contrast, Gram stain and culture showed 16.9 and 23.1% positivity, respectively. LPAT correlated well with Gram stain and culture and can be recommended as an adjunct laboratory test for rapid aetiological diagnosis of bacterial meningitis for prompt institution of proper antibiotics.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":34201146,"openaccessinfo":{"externalids":{"MAG":"2072455960","ACL":null,"DOI":"10.4103\/0255-0857.37347","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.bioline.org.br\/pdf?mb07107","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"After apoptosis or necrosis, macrophages clear dead cells by phagocytosis. Although this process is efficient, circulating nucleosomes can occur in certain diseases, presumably reflecting either increased production or impaired clearance. To investigate the generation of blood nucleosomes, graded numbers of apoptotic and necrotic cells were administered to healthy mice, and levels of blood nucleosomes and DNA were determined. Using Jurkat cells as a model, nucleosomes and DNA were detected in the blood after the administration of 108 apoptotic or necrotic cells per mouse by the intraperitoneal route. The kinetics of the response were similar for both types of cells. The role of macrophages was assessed by eliminating these cells with clodronate liposomes or silica. Although clodronate treatment alone produced a peak level of blood DNA, the subsequent administration of dead cells caused no change in DNA levels. In contrast, silica treatment alone did not elicit a blood DNA response, though this treatment limited the rise in DNA from administered cells. Molecular studies showed that the blood DNA following the administration of apoptotic or necrotic cells arose from the mouse and the Jurkat cells, and its size distribution was consistent with apoptosis. Together, these findings suggest that the generation of blood nucleosomes depends on macrophages, with apoptosis a concomitant of a high burden of dead and dying cells.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":39095361,"openaccessinfo":{"externalids":{"MAG":"2069105832","ACL":null,"DOI":"10.1182\/BLOOD-2002-10-3312","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, the thermodynamic and kinetic requirements of heterogeneous and homogeneous nucleation of metallic melting were suggested. Based on the kinetic requirements of nucleation, the mathematic model of wetting angle of heterogeneous nucleation was developed, Based on the wetting angel model, it was predicted that the maximum undercooling of homogeneous nucleation for melts is two thirds of melting temperature. With the wetting angel model, the wetting angles of different catalysts in liquid iron were calculated, and calculation results are in agreement with that of other researchers.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":135949810,"openaccessinfo":{"externalids":{"MAG":"2043526682","ACL":null,"DOI":"10.4028\/www.scientific.net\/MSF.561-565.1941","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"MET is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and degraded by c-CBL E3-ubiquitin ligase. We investigated genetic variations of c-CBL in HNSCC and the relationship between c-CBL and MET expression. High MET, low c-CBL expression was detected in 10 cell lines and 73 tumor tissues. Two novel mutations (L254S, L281F), and the single nucleotide polymorphism (SNP) P782L were identified from archival tumor tissues. 27.3% of loss of heterozygosity was found at CBL locus. Ectopic expression of wild-type c-CBL in SCC-35 cells downregulated MET expression and decreased cell viability. These results suggest MET overexpression is related to altered c-CBL expression, which may influence tumorigenesis.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":2,"2024-10":1,"unknown":2}},"corpusid":18388888,"openaccessinfo":{"externalids":{"MAG":"2395655065","ACL":null,"DOI":"10.18632\/oncotarget.9640","PubMedCentral":"5386642","ArXiv":null},"license":null,"url":"http:\/\/www.oncotarget.com\/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=9640&path%5B%5D=30193","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Extensive testing has been conducted recently on Mg alloys to evaluate their susceptibility to cracking during solidification as a result of the increasing use of Mg alloys to reduce the vehicle weight. A tool is needed to predict, based on the phase diagram, the most crack-susceptible solute content and the maximum crack susceptibility. The tool can be best tested by a wide variety of binary Mg alloy systems, whose phase diagrams are readily available. In the present study the crack susceptibility was calculated for eight binary Mg alloy systems Mg-Al, Mg-Ca, Mg-Ce, Mg-Gd, Mg-La, Mg-Nd, Mg-Y and Mg-Zn using the maximum \u2502dT\/d(fS)1\/2\u2502 as the crack susceptibility index, where T is temperature and fS the fraction of solid. The calculated results agreed with existing data of crack susceptibility testing, thus confirming the index can be used for Mg alloys. It was shown that the crack susceptibility is highest when TE and kE are both low, e.g., Mg-Zn, where TE is the eutectic temperature and kE is the equilibrium partition ratio k at TE. It was found that the liquidus and solidus lines of binary Mg phase diagrams are often curved instead of straight and this makes k < kE for all T > TE, but k = kE has been assumed in all predictions so far. When the liquidus and solidus lines are both significantly curved, predictions based on k = kE can significantly: 1. overestimate the most crack-susceptible solute content, e.g., Mg-Gd and Mg-Y, 2. underestimate a high maximum crack susceptibility, e.g., Mg-Al, Mg-Nd and Mg-Zn, and 3. overestimate the effect of solute back diffusion on the most crack-susceptible solute content, e.g., Mg-Al, Mg-Gd, Mg-Nd and Mg-Y.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":237528260,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2139\/ssrn.3301216","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Low power and lossy networks have been an active area of research. Numerous protocols have been proposed for routing in these networks using metrics like hop count, delay, bandwidth etc. The IETF ROLL group has proposed a proactive gradient protocol called RPL. However, for a network with few mobile sinks calculating gradients using proactive approach is not energy efficiency. This paper proposed a multipath routing protocol for Wireless Sensor Networks with mobile sinks, called MDMR. Directed Acyclic Graphs (DAGs) are required for WSNs organization because of their route redundancy to the root. MDMR is based on RPL framework. By broadcasting DAG construction messages including metrics, such as, hop count, node energy and link quality indication, protocol constructs DAG and provides path redundancy. This allows nodes to find multiple alternative paths easily while link failures. Keywords-WSN; Routing; DAG; RPL.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":54718701,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper mainly discusses the selection of the technical parameters of fully-mechanized top-coal caving mining using the neural network technique. The comparison between computing results and experiment data shows that the set-up neural network model has high accuracy and decision-making benefit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":107845898,"openaccessinfo":{"externalids":{"MAG":"169958884","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose: The purpose of this study was to develop the tool that can be used for measuring and appraising the performance of Oncology Advanced Practice Nurse(APN). Method: On the basis of some articles about roles of oncology APN, the researcher made a temporary tool and verified both content validity and face validity. Also the reliability and construct validity were verified. Result: The reliability of this tool was measured by internal consistency. Cronbachs' was .92. The method of verification of construct validity was used known group technique because of small numbers of Oncology APN. Conclusions: This performance appraisal tool of Oncology APN was verified by both the reliability and construct validity. In future, this tool will be able to be used for appraisal and verifying of nursing care of Oncology APN.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":76218220,"openaccessinfo":{"externalids":{"MAG":"2379324329","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Office for National Statistics (ONS) is transforming the way we produce population and migration statistics, to a system that is led by administrative data. \nPopulation and migration statistics underpin a wide variety of other statistics and inform a vast range of decisions, including pensions forecasting and provision of local services. These statistics are also used to help inform public debate, it is therefore essential that these statistics are accurate and timely. Until now the census has formed the cornerstone of these statistics, with updates from other surveys and some administrative data. Enabled by new data sharing powers in the Digital Economy Act (2017), we now have the opportunity to make use of more data: and this is essential to better understand our rapidly changing population at both national and local levels, and the wider policy impact and context. \nWe know that there is no single, comprehensive data source that tells us everything about the population. Therefore, we are developing 'data-driven rules' to use as part of a future system. This focuses on identifying the strengths of individual data sources and integrating them to provide richer understanding of how our population is changing. \nThis approach will also allow us to be flexible in implementing different definitions to understand sub-groups of the population. For example, the daytime population to understand the impact that the increasingly more mobile population has on different services. \nWe have undertaken research progressing administrative data-based population estimates, linked data to inform our understanding about migration patterns, reflecting the changing population and the impact that this has on society. The session will provide the latest on the research that ONS has carried out into the potential of administrative data in supporting and delivering a new system that can offer more responsive, frequent and timely insights into our society.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":213502480,"openaccessinfo":{"externalids":{"MAG":"2990703058","ACL":null,"DOI":"10.23889\/ijpds.v4i3.1194","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.23889\/ijpds.v4i3.1194","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background While an estimated 70%\u201375% of the health workforce are women, this is not reflected in the leadership roles of most health organisations\u2014including global decision-making bodies such as the World Health Assembly (WHA). Methods We analysed gender representation in WHA delegations of Member States, Associate Members and Observers (country\/territory), using data from 10 944 WHA delegations and 75\u2009815 delegation members over 1948\u20132021. Delegates' information was extracted from WHO documentation. Likely gender was inferred based on prefixes, pronouns and other gendered language. A gender-to-name algorithm was used as a last resort (4.6%). Time series of 5-year rolling averages of the percentage of women across WHO region, income group and delegate roles are presented. We estimated (%) change \u00b1SE of inferred women delegation members at the WHA per year, and estimated years\u00b1SE until gender parity from 2010 to 2019 across regions, income groups, delegate roles and countries. Correlations with these measures were assessed with countries' gender inequality index and two Worldwide Governance indicators. Results While upwards trends could be observed in the percentage of women delegates over the past 74 years, men remained over-represented in most WHA delegations. Over 1948\u20132021, 82.9% of delegations were composed of a majority of men, and no WHA had more than 30% of women Chief Delegates (ranging from 0% to 30%). Wide variation in trends over time could be observed across different geographical regions, income groups and countries. Some countries may take over 100 years to reach gender parity in their WHA delegations, if current estimated trends continue. Conclusion Despite commitments to gender equality in leadership, women remain gravely under-represented in global health governance. An intersectional approach to representation in global health governance, which prioritises equity in participation beyond gender, can enable transformative policymaking that fosters transparent, accountable and just health systems.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":251767294,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmjgh-2022-009312","PubMedCentral":"9403126","ArXiv":null},"license":"CCBY","url":"https:\/\/gh.bmj.com\/content\/bmjgh\/7\/8\/e009312.full.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"In 150 patients with oligozoospermia a testis biopsy of both testes was performed. In 76% the patients were 25-35 years old. Most of them had a sperm count less than or equal to 8.1 million\/ml ejaculate (in the group of 0.3-1.1 million spermatozoa\/ml ejaculate 32%, in the group of 1.2-8.1 million spermatozoa\/ml ejaculate 43.3%, and in the group of 8.2-20.0 million spermatozoa\/ml ejaculate 26.5%). The tissue of the testis was examined by the semithin slide technique. This method was preferred instead of the routinely used paraffin slide technique, because is semithin slides the different cells of the spermatogenesis as well as its pathological forms can be classified nearly to the limit of resolving power under a light microscope. Examples of histological pictures were given. In a statistical study especially the connection between tubules wall and cells of the spermatogenesis was examined. The tubule diameter which might influence the relation of the number of cells\/tubule wall was connected. For all germ cells it could be observed, that the number of patients with the various germ cells decreased with thickening of the tubule wall. In this collective the high number of patients with a reduced number of spermatogonia was remarkable, as well as the number of patients with degenerating spermatocytes I degree and with pathological spermatids. These spermatids had especially abnormalities of the acrosom and of the nucleus. Furthermore the investigations revealed that the number of the germ cells in the tubules increase with higher spermatozoa density. But in the all cases the various numbers of this material showed only tendencies but no statistical significances.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":23074407,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal enzymes in three contrasting groups: (i) women with ovulatory dysfunctional uterine bleeding and users of intrauterine contraceptive devices; (ii) breastfeeding post-partum women in whom there are long periods of amenorrhoea, particularly in the early months post-partum; and (iii) normal cycling women. It was found that the total activity of lysosomal enzymes, particularly acid phosphatase and N-acetyl-beta-D-glucosaminidase, was markedly elevated (P < 0.001) in IUCD-exposed endometrium, and endometrium from women with dysfunctional uterine bleeding when compared with endometrium from women with a history of entirely normal menstrual periods or that in post-partum breastfeeding women. The activity of alpha-L-fucosidase was moderately elevated in IUCD users (P < 0.05) and ovulatory dysfunctional uterine bleeding (P < 0.05), whereas alphaD-mannosidase activity was elevated in ovulatory dysfunctional uterine bleeding (P < 0.05), but decreased in IUCD users (P < 0.01). No significant differences were observed in the lysosomal enzyme activities of breastfeeding post-partum women and normal cycling women. These results show that total endometrial tissue activity of four lysosomal enzymes was substantially increased throughout the cycle in most circumstances in women with two different causes for increased menstrual bleeding. This suggests a contributory role to the increased bleeding.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":560091,"openaccessinfo":{"externalids":{"MAG":"2128249846","ACL":null,"DOI":"10.1093\/MOLEHR\/6.3.258","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using Machine Learning (ML) algorithms for classification of the existing residential neighbourhoods and their spatial characteristics (e.g. density) so as to provide plausible scenarios for designing future sustainable housing is a novel application. Here we develop a methodology using a Random Forests algorithm (in combination with GIS spatial data processing) to detect and classify the residential neighbourhoods and their spatial characteristics within the region between Oxford and Cambridge, that is, the 'Oxford-Cambridge Arc'. The classification model is based on four pre-defined urban classes, that is, Centre, Urban, Suburban, and Rural for the entire region. The resolution is a grid of 500 m \u00d7 500 m. The features for classification include (1) dwelling geometric attributes (e.g. garden size, building footprint area, building perimeter), (2) street networks (e.g. street length, street density, street connectivity), (3) dwelling density (number of housing units per hectare), (4) building residential types (detached, semi-detached, terraced, and flats), and (5) characteristics of the surrounding neighbourhoods. The classification results, with overall average accuracy of 80% (accuracy per class: Centre: 38%, Urban 91%, Suburban 83%, and Rural 77%), for the Arc region show that the most important variables were three characteristics of the surrounding area: residential footprint area, dwelling density, and number of private gardens. The results of the classification are used to establish a baseline for the current status of the residential neighbourhoods in the Arc region. The results bring data-driven decision-making processes to the level of local authority and policy makers in order to support sustainable housing development at the regional scale.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":244399492,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1742-6596\/2042\/1\/012017","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1088\/1742-6596\/2042\/1\/012017","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES\nTo evaluate the toxicity and effectiveness of piperacillin+tazobactam and amikacin compared with a reference treatment with ceftazidime and amikacin given as first line therapy in neutropenic patients with fever.\n\n\nMETHODS\nA multicentric randomized trial was conducted in 222 adults who had fever (38 degrees C for > 3 h) during a period of aplasia (white cell count < 0.5.10(9)\/l for 22.9 +\/- 10.4 days) induced by chemotherapy for acute leukaemia (68.1%) or by bone marrow autograft for lymphoma, myeloma or solid tumour (30.3%). 109 patients were assigned to the piperacillin (12 g\/d)\/tazobactam (1.5 g\/d)+amikacin group and 113 to the ceftazidime (3 g\/d)+amikacin group. Evaluation criteria were the frequency of apyrexia after a 72-hour antibiotic regimen and major infectious events defined as death due to infection and severe infections causing a delay in the chemotherapy protocol.\n\n\nRESULTS\nData obtained in 188 patients who fulfilled all the protocol criteria were evaluated. The episode of fever was controlled better with the piperacillin\/tazobactam+amikacin combination (apyrexia achieved in 60.6% of the patients vs 44.7% in the ceftazidime+amikacin group, p = 0.028) and there were fewer superinfections (23% vs 41% respectively, p < 0.008). Tolerance was similar in the two groups. In vitro, 56% of the strains resistant to piperacillin and isolated prior to treatment were sensitive to the piperacillin\/tazobactam combination. Among the strains isolated (41 Gram-, 61 Gram+), 72% were sensitive to ceftazidime and 84% were sensitive to the piperacillin\/tazobactam combination. There were 16 deaths due to infection (8.5%) with no difference according to antibiotic regimen. There was no difference in toxicity.\n\n\nCONCLUSION\nTolerance was similar in the two groups. A combined regimen of piperacillin\/tazobactam can be proposed as first line treatment for neutropenic patients with fever.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":10268209,"openaccessinfo":{"externalids":{"MAG":"2415069422","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Honey already exists in the world millennia years ago. It is commonly used in daily lifestyle such as drink and energy booster at that time. Apart from that, it is also treated as traditional and natural supplement. In ancient time, humans already started to use it as traditional medicine. Nowadays, medical technology has advanced by leaps and bounds and thus becoming a standard globally. People trusts in the advance medical technology instead of the traditional medicine such as honey. However, there are certain of peoples who still believed on the health benefit provided by honey. Moreover, the world population of human living in this world is around 7 billion which still increasing year by year. The production of honey is still far from enough to fulfil the human's needs and wants. In addition, humans thought is varies from each other, therefore humans has different perceptive toward the health benefit provided by honey. Thus, the main purpose of this study is to determine the factors influence the consumer purchasing behaviour towards honey in Malaysia. A survey was conducted among 1018 respondents from each states of Malaysia. In this study, theory of reasoned action model has been adapted in order to have a better and clear understanding towards the consumer purchasing behaviour. Besides that, the data analyses were conducted by descriptive analysis, reliability analysis, factor analysis and multiple regression analysis. The factors that extracted from the factors analysis are health benefit, brands, colour, price, and taste. Based on the multiple regression analysis, the correlation has shown relationship between the factors and the consumer purchasing intention is low correlation but the F ratio is highly significant. Therefore, it has indicated that the honey purchaser is suitable in the model.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":204490501,"openaccessinfo":{"externalids":{"MAG":"2974574615","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Systems and methods of a Web service for remote terminal service application discovery are described. In one aspect, a Web service in an Intranet is provided. The Web service is coupled to a public network. The Web service facilitates remote client computer discovery over the public network of information corresponding to application(s) deployed on the Intranet. The remote client computer is external to the Intranet. The application(s) are configured for terminal server based access for a user of the remote client computer.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":67458607,"openaccessinfo":{"externalids":{"MAG":"2786771050","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The study seeks to establish an anchoring, in time, of the Romanian primary wheat supply, having regard to the importance of the respective product for the Romanian agricultural economy (the second crop plant at national level based on cultivated areas and total yields). In the same context, the importance of wheat crop can be revealed through the role that this product can play as an export item especially in years characterized by considerable levels of yields. In the period 2014-2016, the levels of the cultivated area and the total production (2,119,062.67 ha and 7,992,788.67 t) are highlighted, but also the less appropriate performance in terms of average production (3,771 kg\/ ha). It is worth mentioning that certain aspects that influence the preforms of the respective culture need to be improved: the stronger atomicity of producers, the financing measures (non-reimbursable EU funds not accessible to the large mass of producers), the adequate upgrading of capital items mechanical capital and the upgrading of storage and preservation areas), the protection of certain categories of producers from the sensitive aspects of the market (for example, the evolution of the marketing prices). .","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":174774487,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Cinnamon is a spice that has ancient origins and is popularly used as flavorings, as a condiment and in cooking. Cinnamon is also known to provide various medicinal benefits that include lowering of blood cholesterol, for diabetes. Cinnamon is obtained from the bark of the Cinnamon tree.. The importance of cinnamon in cookery and medicine has been known since time immemorial, which is evident from the fossil remains that interpret its cultivation in ancient times. Today, It's not only known for as a strong flavored spice, but it has gained tremendous applications in therapeutic intervention. The bark itself is used for extracting essential oil. As far as cinnamon nutrition is concerned, it contains more than 80 nutrients, beneficial for proper functioning of the body. The unique aroma and pungency of cinnamon are attributed to the compounds cinnamaldehyde and cinnamic aldehyde. Giving due importance to the health benefits of cinnamon, rigorous studies have been done regarding the nutrition facts. Low in cholesterol, saturated fats, sugar, and sodium, It's an excellent flavoring ingredient for people with heart related problems. Cinnamon contains polyphenols, which are natural antioxidants, that help in regulating blood sugar levels. Certain compounds present in cinnamon stimulate the insulin receptors and thus help the body to use up glucose in the right way. Studies have shown that cinnamon can prove beneficial for those who suffer from diabetes, especially type 2 diabetes. Cinnamon improves insulin resistance, that helps in weight control. This explains the use of cinnamon for weight loss. The total calorie content in 6.8 g of cinnamon is 17. Out of this, only 1 calorie is contributed by fats (total fat content is 0.2 g per 1 tablespoon) and zero % from saturated fats. Overall, It's good for health conscious people. The amount of carbohydrates in 1 tablespoon serving size is approximately 5.5 g. Unlike other carbohydrate containing food items, it shows a negligible amount of sugar (only 0.1g per 1 tablespoon). The high %age content of dietary fiber (3.6 g in 1 tablespoon) also makes it a preferred spice among people having digestive problems. Using it regularly will reduce indigestion, constipation, and intestinal disorders. The concentration of protein in cinnamon is relatively low, as compared to that of calcium, iron, and dietary fiber content. Serving 6.8 g of the same will provide you 0.3 g proteins. Needless to say, you get proteins from other food ingredients. So, It's not at all a concerning issue. It's good source of calcium and iron; having 1 tablespoon of cinnamon is sufficient to yield 14 % calcium and 31 % iron of the daily requirements of an adult. Nevertheless, the requirements may vary slightly as per your calorie needs. It also contains high amounts of vitamin A and C along with minerals like Zn, K, Mg, and Mn. A 6.8 g serving provides 20 % vitamin A and 12 % vitamin C of the daily requirements of an adult.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":115997644,"openaccessinfo":{"externalids":{"MAG":"2905738837","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"With ever-increasing demands of smaller size, lighter weight and cost effective for all forms of AC-DC consumer electronics, and wire winding transformers have been most used in isolated adaptor for over a century. The most popular isolated AC-DC adaptor topology is the flyback, but the leakage inductance and switching losses of a traditional flyback limit the switching frequency and prevent the ability to achieve a small solution size. This paper demonstrates new ways to optimize flyback topology with low voltage auxiliary switch to produce much higher efficiencies, even while switching at a higher frequency for adapter application.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":256877994,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/PESA55501.2022.10038428","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The realm of this paper is the provision of multimedia services based on matching users' preferences and multimedia content descriptions. The main concept explored is the usage of ontology tools for mitigating frailties found in tag based matching processes due to their lack of semantic knowledge and their context dependence. The integration of ontology tools in CN architectures based on open standards (MPEG-7 and IMS) is proposed and assessed in this paper. The results obtained via non-functional tests enable to conclude that these tools provide enhanced matching results without a negative impact on both the CN size and its performance.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":18365547,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1109\/EUROCON.2011.5929395","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Monoclonal antibodies (mAbs)\u2014proteins engineered to bind to particular antigens\u2014can serve as medications for cancer, autoimmune diseases, and other conditions. During mAb development, researchers often tweak the antibody's underlying DNA sequence and screen for variants that give the highest yields when expressed in cells. Chinese hamster ovary (CHO) cells are typically used to produce these variants for screening, but that process takes a minimum of seven days to express the proteins. Researchers have now taken cells out of the equation to develop a faster, cell-free synthesis platform for making mAbs by modifying the formulation of a commercially available CHO cell extract (ACS Synth. Biol. 2017, DOI: 10.1021\/acssynbio.7b00001). Michael C. Jewett of Northwestern University, Varnika Roy of biologics company MedImmune, and colleagues added a glutathione buffer solution and isomerase enzymes to the CHO extract to ensure the correct formation of the disulfide bonds that hold together the antibodies' four su...","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":90324863,"openaccessinfo":{"externalids":{"MAG":"2613505873","ACL":null,"DOI":"10.1021\/CEN-09520-SCICON002","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The evolution of legislation on sexual crimes shows that only two approaches have been used to address this issue: the medical and criminal approach. These approaches, however, have proven to be ineffective when used independently or jointly to resolve the problem of sex offenses. The failure of these approaches is not a coincidence. It is the direct effect of the social construction of sex offenders. Today, society promulgates the myth that once a sex offender always a sex offender, which means that these individuals are innately incapable of changing their behavior. This construct generates feelings of rejection, fear and discrimination toward sex offenders. These social feelings are incorporated into the law, precluding the government from dealing with the problem itself. However, as history demonstrates the social construction of sex offenders is a mutable concept. Thus, this paper argues that the best approach to address the issue of sex offenses is to engage in a therapeutic approach that departs from the understanding that is necessary to reconstruct the social perceptions of sex offenders. To do so, this article proposes the creation of a Sexual Offenses Court that takes as its starting point the sex offenders rather that the victims and that utilizes a negotiation approach that will help the victim cope with the events and will prevent offenders from relapsing.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":3}},"corpusid":147338321,"openaccessinfo":{"externalids":{"MAG":"2263015334","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Mitomycin C and hyperthermia are both toxic to chronically hypoxic EMT6 tumor cells. Combinations of this drug and heat were tested in vitro in normally aerated and chronically hypoxic EMT6 mouse mammary tumor cells to establish whether greater than additive cytotoxicity could be achieved by combined treatment. Cell survival was measured at four concentrations of mitomycin C (0.01, 0.1, 1.0, and 10 microM) at 37 degrees or at elevated temperatures (41, 42, and 43 degrees) for durations of 1, 2, 3, and 6 hr. At 42 degrees, exposure to mitomycin C for 3 and 6 hr produced a 2- to 3-fold increase in hypoxic tumor cell kill at all drug concentrations over that expected for strict additivity. A 15-fold enhancement in the kill of hypoxic tumor cells was obtained at 1.0 and 10 microM mitomycin C at 43 degrees for 6 hr of exposure. Under most conditions, additivity was observed for the antibiotic and heat in oxygenated cells, except at 43 degrees with 0.01 and 0.1 microM mitomycin C following 3 and 6 hr of treatment, conditions under which a 5- to 10-fold potentiation of tumor cell kill was obtained. The rate of formation of reactive metabolites from mitomycin C under anaerobic conditions in EMT6 cell-free preparations was measured. A 30 to 50% increase in alkylating activity was observed at elevated temperatures, suggesting that the enhanced cytotoxicity of mitomycin C with heat toward hypoxic cells may, in part, be due to an increase in activation of the drug.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":25862771,"openaccessinfo":{"externalids":{"MAG":"2168912348","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper studies the design of tax systems that implement a planner's second-best allocation in a market economy. An example shows that the widely used Mirrleesian (1976) tax system cannot implement all incentive-compatible allocations. Hammond's (1979) \"principle of taxation\" proves that any incentive-compatible allocation can be implemented through at least one tax system. However, this tax system is often undesirable since it severely restricts the choice space of agents in the economy. In this paper we derive necessary and sufficient conditions to verify whether a given tax system can implement a given incentive-compatible allocation. We show that when an incentive-compatible allocation is on the Pareto frontier, and\/or surjective onto the choice space, a tax system that equates the marginal tax rates to the optimal wedges can implement the second best, without restricting the choice space of the agents. It follows that the Mirrleesian tax system can successfully implement the second best in the identified classes. Since the second-best allocation of welfarist planners is always on the Pareto frontier, our results (ex post) validate most tax systems proposed in the literature. Outside of the identified classes, the planner may need to restrict the choice space of agents to implement its second best in the market. This sheds new light on rules, quotas and prohibitions used in real-world tax and benefit systems.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":53381360,"openaccessinfo":{"externalids":{"MAG":"1517579147","ACL":null,"DOI":"10.2139\/SSRN.2494724","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Police officers must have a readiness to respond quickly and sometimes lastingly to extremely taxing physical situations so they need strong stamina and nutritious food. However, many police officers are obese because they like to eat foods high in calories and fat. This research aims to know the relationship between food preferences and food consumption of high\u2013calorie high\u2013fat as well as knowing the factors that relate to food preferences on police whose had a problem with obesity. The design of this study was cross sectional and carried out at Madiun Resort Police Department, Indonesia. Methods and materials this study is population was all obese police officers totaling 145 police officers and we used the total population as a sampling method. The sample criteria had IMT \u2265 25 kg m, not in a special diet, age \u2265 24 yr, male. Food consumption was measured using Semi\u2013Quantitative Food Frequency Questionnaire (SQFFQ). Food preference was measured using the food preference questionnaire. This research used PR to get the result of correlation and chi\u2013square to test of significance. The result, majority of obese police officers like high\u2013calorie high\u2013fat food (56.73 %) and have overconsumption of that food (50.75 %). The most preferred of high\u2013calorie high\u2013fat food is fried tempeh (97.28 %), fried tofu (94.03 %), and fried chicken (86.57 %). The research showed that the prevalence risk of obese police who have overconsumption of high\u2013calory high\u2013fat in the group that likes high\u2013calorie high\u2013fat foods was 2.12 times higher than obese police who did not like high\u2013fat high\u2013calorie foods. The conclusion of this study is a correlation between food consumption and food preference, but there is no relationship between food preferences and nutrition knowledge, income, food prices.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":226505329,"openaccessinfo":{"externalids":{"MAG":"3037805525","ACL":null,"DOI":"10.36295\/asro.2020.23813","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.36295\/asro.2020.23813","status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Studying the attributes of individual debitage pieces often leads to excessive analytic time and costs and to ambiguous behavioral interpretations. The latter is due both to the subjectivity inherent in the process and to the complex relationship which may exist between flake attributes and flintknapping processes. Mass analysis or aggregate analysis of flaking debris focuses on size distribution and flake shape information derived from size-graded debitage samples which are studied en masse. Mass analysis offers clear advantages in objectivity and the ability to handle numerically large samples, including data from broken as well as whole flakes. In this paper several experimental data sets are studied by the mass analysis procedure to illustrate the interpretive power of the method. Guidelines for recording mass analysis data are discussed, as are several means for extracting and presenting useful technological information inherent in the basic mass analysis data set. Examples are offered which illustrate application of the method for interpretation of flaking debris aggregates from multiple Northern Plains archeological sites reflecting great functional and settlement diversity.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":108567904,"openaccessinfo":{"externalids":{"MAG":"1976430104","ACL":null,"DOI":"10.1525\/AP3A.1989.1.1.85","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We develop multi-step gradient methods for network-constrained optimization of strongly convex functions with Lipschitz-continuous gradients. Given the topology of the underlying network and bounds on the Hessian of the objective function, we determine the algorithm parameters that guarantee the fastest convergence and characterize situations when significant speed-ups over the standard gradient method are obtained. Furthermore, we quantify how uncertainty in problem data at design-time affects the run-time performance of the gradient method and its multi-step counterpart, and conclude that in most cases the multi-step method outperforms gradient descent. Finally, we apply the proposed technique to three engineering problems: resource allocation under network-wide budget constraint, distributed averaging, and Internet congestion control. In all cases, our proposed algorithms converge significantly faster than the state-of-the art.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":15219804,"openaccessinfo":{"externalids":{"MAG":"2763066689","ACL":null,"DOI":"10.1109\/TSP.2013.2278149","PubMedCentral":null,"ArXiv":"1211.2132"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Purpose \n \n \n \n \nThe purpose of this paper is to examine the differential effect of reciprocal and negotiated social exchanges in establishing workplace relationship cohesion, providing a mediating influence between social constructed initiatives (i.e. internal socialization and support) and internal customers' psychological connectedness. \n \n \n \n \nDesign\/methodology\/approach \n \n \n \n \nData were gathered via a national online survey of service employees in Australia, representing a diverse range of service industries (e.g. retail (food\/non-food), health, financial, administrative support, real estate, household, insurance, education and training, etc.). \n \n \n \n \nFindings \n \n \n \n \nReciprocal-exchange relationship quality fully mediates the relationship between internal socialization and psychological connectedness; and negotiated-exchange relationship quality partially mediates the relationship between internal support and psychological connectedness of internal customers. \n \n \n \n \nResearch limitations\/implications \n \n \n \n \nWhile the findings reported herein support the salience of interpersonal relationship quality enhancing the internal performance of the organization, it is essential to consider how the findings link to externally perceived performance (i.e. from the customer's perspective). Future research is guided by a framework that the authors propose as a result of the study's findings to facilitate research in this under-researched area. \n \n \n \n \nPractical implications \n \n \n \n \nThe development of sound socially relevant internal marketing strategies is vital to the long-term health and prosperity of the firm and its internal counterparts necessitating a move beyond transactional internal marketing, reflecting \"pay for service\" organizational thinking. \n \n \n \n \nOriginality\/value \n \n \n \n \nThe examination of internal relationship cohesion and how this effects internal customers' allegiance to their organizations addresses an important research gap and, thus, provides a significant contribution to both theory and practice.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":168352601,"openaccessinfo":{"externalids":{"MAG":"2579207247","ACL":null,"DOI":"10.1108\/JSTP-07-2015-0175","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Presented here is a study of the application of high-intensity ultrasound in the production of amorphous alloys, amorphous coatings, metallic coatings, and organic waste abatement. The results of amorphous alloy production from organometallic precursors is discussed. Amorphous FeP and FeCo were produced and the effects of cavitation on the reagents is related to the product compositions.\n\nAmorphous coating are produced from cosonicating Fe(C0)5 with alumina. The products of these reactions are analyzed by SEM, EDX and standard BET analysis. The results are compared with crystalline iron and traditional methods of producing iron coating on alumina.\n\nSonochemically-induced metallic coatings studies were performed. Mixed-metal systems (Ni\/Co, Al\/Ni, Al\/Co, Ni\/Mg and Cu\/Mo) were cosonicated to tribologically induce metallic coatings. The products were characterized by SEM and EDX analysis.\n\nUltrasound was studied as a means to remove volatile hydrocarbons at low-level concentrations from water. Aliphatic hydrocarbons (hexane to tetradecane) were sonicated in water, and their degradation rates were determined. Aromatic hydrocarbons (benzene, toluene, and m-xylene) were sonicated in water and their degradation rates were determined. Correlations among hydrocarbon, vapor pressure and reaction efficiency is discussed.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":92063622,"openaccessinfo":{"externalids":{"MAG":"100441500","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Introduction Leslie Rahl Part 1: OVERVIEW 1 Risk Budgeting: The Next Step of the Risk Management Journey - The Veteran's Prospective Leslie Rahl 2 Crisis and Risk Management Myron Scholes PART 2: UNDERSTANDING RISK BUDGETING 3 Risk Budgeting: Managing Active Risk at the Total Fund Level Kurt Winkelmann 4 The Dangers of Historical Hedge Fund Data Andrew B. Weisman and Jerome Abernathy 5 Value-at-Risk for Asset Managers Christopher L. Culp, Ron Mensink and Andrea M.P. Neves 6 Risk Budgeting fore Pension Funds and Investment Managers using VAR Michelle McCarthy 7 Risk Budgeting for Active Investment Managers Robert Litterman, Jacques Longerstaey, Jacob Rosengarten and Kurt Winkelmann 8 Risk Obsession: Does it Lead to Risk Aversion? Amy B. Hirsch 9 Market Neutral and Hedged Strategies Joseph G. Nicholas 10 The Infrastructure Challenge: Empowering the Stakeholder through the Successful Deployment of Technology and Data Gabriel Bousbib PART 3: PRACTITIONERS' THOUGHTS: CASE STUDIES IN RISK BUDGETING 11 Risk Budgeting in a Pension Fund Leo de Bever, Wayne Kozun and Barbara Zvan 12 Risk Budgeting with Conditional Risk Tolerance Michael de Marco and Todd E. Petzel 13 VAR for Fund Managers Stephen Rees","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":152527557,"openaccessinfo":{"externalids":{"MAG":"1513090335","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper, we introduce and study a random fuzzy complementarity problem in Hilbert spaces. We define an iterative algorithm for finding the approximate solutions of this class of complementarity problem and establish the convergence of iterative sequences generated by proposed algorithm. Our result can be viewed as generalization of many known corresponding results. One example is constructed in support of our problem.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":116389239,"openaccessinfo":{"externalids":{"MAG":"50467989","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Medical Diagnosis Systems play a vital role in medical practice and are used by medical practitioners for diagnosis and treatment. In this paper, a medical diagnosis system is presented for predicting the risk of cardiovascular disease. This system is built by combining the relative advantages of genetic algorithm and neural network. Multilayered feed forward neural networks are particularly suited to complex classification problems. The weights of the neural network are determined using genetic algorithm because it finds acceptably good set of weights in less number of iterations. The dataset provided by University of California, Irvine (UCI) machine learning repository is used for training and testing. It consists of 303 instances of heart disease data each having 14 attributes including the class label. First, the dataset is preprocessed in order to make them suitable for training. Genetic based neural network is used for training the system. The final weights of the neural network are stored in the weight base and are used for predicting the risk of cardiovascular disease. The classification accuracy obtained using this approach is 94.17%.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":236361846,"openaccessinfo":{"externalids":{"MAG":"3165104887","ACL":null,"DOI":"10.48175\/IJARSCT-1166","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nRenal cancer is one of the common malignant tumors of the urinary system, seriously threatening human being's health. The current discoveries, however, are far enough for efficient and secure treatment of renal cancer.\n\n\nAIMS\nThe aim was to explore the mechanism of matrix metalloproteinase-7 (MMP-7) protein in renal carcinoma cell metastasis by bioinformatics analysis.\n\n\nMATERIALS AND METHODS\nBioinformatics methods were used to analyze the composition of amino acids, as well as transmembrane structure, coiled coils, subcellular localization, signal peptide, functions and structures at all levels.\n\n\nRESULTS AND CONCLUSIONS\nIt showed that the gene MMP-7 totally had 1131 bp. A peptide chain containing 267 amino acids was encoded in the coding region. Based on random coil, \u03b1 helix, and further super-helix, it had formed a stable neutral hydrophilic protein. The subcellular location analysis indicated that the protein was located outside the cell. The mature peptide started from the 18th amino acid, and its front-end was the sequence of the signal peptide, belonging to the secreted protein. Analysis of the functional domain showed that this protein had two functional domains, the PG binding domain, and the zinc finger binding domain. Moreover, the protein, which was cross-linked with it, was also one related to cancer cell proliferation and metastasis. To sum up, MMP-7 is a stable neutral hydrophilic secreted protein, and it may play a vital role in the invasion and metastasis of cancer cells.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":27474087,"openaccessinfo":{"externalids":{"MAG":"2342074299","ACL":null,"DOI":"10.4103\/0019-509X.180835","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC\n\nThe poster will prtray the various steps an advocate can take in the world of breast cancer. It will also define the journey through self-advocacy, local advocacy, patient advocacy and legislatie advocacy. These actions support bridging the gap trhough education and empowerment.\n\nCitation Format: Desiree Walker. Bridging the gap: An advocate's breast cancer journey. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr ADV23. doi:10.1158\/1538-7445.AM2013-ADV23","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":72916728,"openaccessinfo":{"externalids":{"MAG":"2067825801","ACL":null,"DOI":"10.1158\/1538-7445.AM2013-ADV23","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Proceedings: AACR 103rd Annual Meeting 2012\u2010\u2010 Mar 31\u2010Apr 4, 2012; Chicago, IL\n\nAdoptive transfer of melanoma-reactive CD8+ T Cells (CTL) has demonstrated antitumor activity that may be enhanced by prolonging survival of transferred T cells in vivo. CTLA4 is up-regulated on activated T cells and when engaged to its B7-ligand, delivers inhibitory signals that impede TCR signaling, IL-2 transcription, and T cell proliferation. Human anti-CTLA4 monotherapy benefits about 25% of patients (pts), but most pts likely lack a sufficiently high frequency of pre-existing melanoma-reactive T cells susceptible to CTLA4 blockade and fail to respond. We propose a combined biologic strategy involving the adoptive transfer of melanoma-reactive CTL with concurrent administration of anti-CTLA4 as a means of enhancing the in vivo CTL survival and anti-tumor effect. Autologous polyclonal CTL were generated by multimer sorting and expanding melanoma-specific CTL lines to increase the probability of infusing cells derived from central memory (Tcm), as such cells were shown to exhibit prolonged persistence and superior replicative potential in murine and non-human primate models. Ex-vivo cultures were supplemented with the \u03b3c-chain cytokine Interleukin-21 (IL-21), which has been demonstrated to promote effector CTL helper-independence and to arrest differentiation at a Tcm stage. To date, 6 pts with bulky, therapy-resistant progressive melanoma were infused with 1010\/m2 polyclonal IL-21-derived CTL targeting MART1. The infusions were preceded by intravenous cyclophosphamide 300mg\/m2 and followed by low-dose subcutaneous IL-2 (250,000 IU\/m2 BID) x 14 days. Anti CTLA4 (ipilimumab) 3mg\/kg was started on the day after the CTL infusion. Side effects included fevers and chills starting 1-2 hours post-CTL infusion and moderately erythematous maculo-papular skin rashes in all 6 patients. No unexpected or serious (grade \u22653) toxicity was observed. Persistence of the infused CTL to frequencies >2x baseline levels was documented at 6 weeks (5\/5 evaluable pts) and 12 weeks (4\/4 pts). 3\/5 and 2\/3 evaluable pts experienced stable disease by RECIST 1.1 criteria at 6 and 12 weeks respectively. One patient had a delayed response with 25% reduction in tumor mass at 12 weeks after having failed previous ipilimumab monotherapy and prior CTL therapy without CTLA4 blockade. Tracking of infused multimer+ CTL in vivo revealed acquisition of both phenotypic (CD27, CD28, CD127, CD62L and CCR7) and functional (secretion of IL-2 in response to cognate antigen) characteristics of Tcm within 12 weeks. Our preliminary results suggest polyclonal IL-21-stimulated CTL targeting melanoma in combination with Ipilmumab is safe and promotes persistent anti-tumor responses such that CTL are poised for enhanced therapeutic activity in vivo.\n\nCitation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-136. doi:1538-7445.AM2012-LB-136","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":72879594,"openaccessinfo":{"externalids":{"MAG":"2057306093","ACL":null,"DOI":"10.1158\/1538-7445.AM2012-LB-136","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The trend in medical equipment is toward compact and integrated low-cost medical test devices. Fluorescence-based assays are used to identify specific pathogens through the presence of dyes, but typically require specialized microscopes and narrowband optical filters to extract information. We present a novel, high-sensitivity, cost-effective, cross-polarization scheme to filter out excitation light from a fluorescent dye emission spectrum. This concept is demonstrated using an inverted microscope fitted with a halide lamp as the excitation source and an organic photo voltaic (organic photodiode) cell as the intensity detector. The excitation light is linearly polarized and used to illuminate a microfluidic device containing a 1 volume of dye dissolved in ethanol. The detector is shielded by a second polarizer, oriented orthogonally to the excitation light, thus reducing the magnitude of the detector photocurrent by about 25 dB. The signal due to fluorescence emission light, which is randomly polarized, is only attenuated by about 3 dB. As proof-of-principle, the fluorescence signal from the dyes Rhodamine 6G (emission wavelength of 570 nm) and Fluorescein (emission wavelength 514 nm) are measured in a dilution series with resulting emission signal being detected by an organic photodiode. Both dyes were detectable down to concentrations of 10 nM. This suggests that an integrated microfluidic device, with an organic photodiode and an organic light emitting excitation source and integrated polarizers, could be fabricated to realize compact and economical lab-on-a-chip devices for point-of-care diagnostics and on-site analysis.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2014-10":1}},"corpusid":23769342,"openaccessinfo":{"externalids":{"MAG":"2131078281","ACL":null,"DOI":"10.1109\/JSEN.2008.918961","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors present the experimental results proving that in the real exploitation of a vehicle or a tractor self-exciting oscillations do not occur in friction pairs of friction clutch. This refers to friction clutches with asbestos, asbestos-free polymer and sintered powder friction pads.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":138026599,"openaccessinfo":{"externalids":{"MAG":"2285807947","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This article reviews the diagnosis of liver metastases by sonography and computed tomography. The ultrasonographic and computer tomographic features of hepatic metastases are described emphasizing the various signs of malignancy and the differential diagnosis of focal liver disease. The advantages and disadvantages of each imaging technique as well as a diagnostic approach in the evaluation of hepatic tumors are discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30217641,"openaccessinfo":{"externalids":{"MAG":"2413347756","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"BACKGROUND\nAngiotensin converting enzyme inhibitors (ACEIs) are recommended in people to treat asymptomatic (occult) dilated cardiomyopathy (DCM). Efficacy of therapy in occult DCM in dogs is unknown.\n\n\nHYPOTHESIS\nACEIs, specifically benazepril hydrochloride (BH), will delay the onset of overt DCM in Doberman Pinschers.\n\n\nANIMALS\nNinety-one Doberman Pinschers were studied, 57 dogs received BH, and 34 dogs no ACEI.\n\n\nMETHODS\nRetrospective study of the medical records of all Doberman Pinschers with occult DCM that received BH or no ACEI between April 1989 and February 2003. Two criteria of left ventricular enlargement were used for enrollment: one independent of body weight (BW) (C1) and the other indexed to BW (C2). Cox proportional hazards analyses were used to identify variables associated with the onset of overt DCM.\n\n\nRESULTS\nOn univariate analysis the median time to onset of overt DCM was significantly longer for the benazepril group (for C1: 425 days for BH, 95% confidence interval [CI] 264-625 days; 339 days for no ACEI, CI 172-453 days, P= .02; for C2: 454 days for BH, CI 264-628 days; 356 days for no ACEI, CI 181-547 days, P= .02). The hazard ratio (HR) (benazepril\/no ACEI) was 0.57, CI 0.35-0.94, P= .03 for C1; HR = 0.56, CI 0.34-0.93, P= .02 for C2. On multivariate analysis, BH significantly delayed onset of overt DCM (HR [benazepril\/no ACEI] = 0.45, CI 0.26-0.78, P < .01, for C1; HR = 0.36, CI 0.21-0.63, P < .01, for C2).\n\n\nCONCLUSIONS\nBH in particular and ACEIs in general might delay the progression of occult DCM. Prospective studies are warranted to test this theory.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36446407,"openaccessinfo":{"externalids":{"MAG":"2553854792","ACL":null,"DOI":"10.1111\/j.1939-1676.2009.0346.x","PubMedCentral":null,"ArXiv":null},"license":"unspecified-oa","url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/j.1939-1676.2009.0346.x","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Survivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":1069313,"openaccessinfo":{"externalids":{"MAG":"2040217580","ACL":null,"DOI":"10.1074\/jbc.M704461200","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"a very similar though less pronounced stimulus intensity control system to that previously observed in humans and that relation of the control system to behavior may also parallel that found in people. The ability of these neurophysiological data to predict individual differences in animal \"personality\" was rather striking. This opens the possibility that common laboratory animals may be used for extensive experimental study of these phenomena. R. A. HALL Santa Clara County Mental Health Services and Institute for Medical Research, San Jose, California 95128 M. RAPPAPORT, H. K. HOPKINS R. GRIFFIN, J. SILVERMAN Agnews State Hospital, San Jose, California 95114 Refemees","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":77611716,"openaccessinfo":{"externalids":{"MAG":"2468983925","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Summary: The serratus anterior-rib composite flap is a well described and versatile flap used for reconstruction in a variety of anatomical regions. However, reconstruction of a thumb defect using this flap has not been well described since first mentioned in the literature by the Buncke et al group 20 years ago. The authors describe the use of this technique for thumb reconstruction in a complex defect from a gunshot wound.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249519375,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1097\/GOX.0000000000004358","PubMedCentral":"9170006","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In vitro glucagon (1-100 microgram\/ml) has been shown to inhibit the degradation of bradykinin by kininases present in kidney microsomes and erythrocytes. Glucagon was less active on kininases present in plasma and was inactive on purified pancreatic carboxypeptidase B. In conscious dogs the intravenous infusion of glucagon (10 microgram\/min) increased urine flow (160%) and urine kinin excretion (130%) and decreased urine kallikrein excretion (14%). It is suggested that in vivo inhibition of kininases might contribute to the biological effects of glucagon.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41387977,"openaccessinfo":{"externalids":{"MAG":"2058115789","ACL":null,"DOI":"10.1530\/ACTA.0.0870552","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lead halide perovskites show remarkable performance when used in photovoltaic and optoelectronic devices. However, the peculiarities of light-matter interactions in these materials in general are far from being fully explored experimentally and theoretically. Here we specifically address the energy level order of optical transitions and demonstrate photon echos in a methylammonium lead triiodide single crystal, thereby determining the optical coherence times T2 for excitons and biexcitons at cryogenic temperature to be 0.79 ps and 0.67 ps, respectively. Most importantly, we have developed an experimental photon-echo polarimetry method that not only identifies the contributions from exciton and biexciton complexes, but also allows accurate determination of the biexciton binding energy of 2.4 meV, even though the period of quantum beats between excitons and biexcitons is much longer than the coherence times of the resonances. Our experimental and theoretical analysis methods contribute to the understanding of the complex mechanism of quasiparticle interactions at moderate pump density and show that even in high-quality perovskite crystals and at very low temperatures, inhomogeneous broadening of excitonic transitions due to local crystal potential fluctuations is a source of optical dephasing.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":245218675,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1021\/acsphotonics.1c01603","PubMedCentral":null,"ArXiv":"2112.08915"},"license":null,"url":"http:\/\/arxiv.org\/pdf\/2112.08915","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Purpose: Germline variants contribute to large fraction of the diversity observed among different ethnic groups and could give better insights in genetic predisposition and susceptibility from one population to another for certain disease including cancer. Decreased mitochondrial OXPHOS is one of the most common phenotypes of cancer cells. Mitochondrial DNA (mtDNA) depletion impairs OXPHOS and adaptive metabolic responses. In this context, DNA polymerase \u03b3 (POLG1) is known to function in human mitochondria and performs critical function of mtDNA replication and repair. POLG1 is the most frequent target of gene mutation and is involved in variety of mitochondrial diseases. POLG1 protein consists of exonuclease, linker and polymerase domain, each with distinct functions. Mutations in exonuclease domain leads to erroneous proofreading and is responsible for increased mutations in mtDNA whereas mutations in polymerase domain leads to erroneous replication and hence depletion in mtDNA. Germline variants in these domains of POLG1 may serve as important signature markers in association studies of individuals in a population study. Through our present study, we identified germline variants, examined copy number variation, expression and regulation of POLG1 gene in human cancers. We provide evidence that altered POLG1 expression as well as germline variations in POLG1 gene contribute to tumorigenesis. Methods: A comprehensive race based bioinformatics analysis of POLG1 gene in European-American and African-American was conducted and several unique germline mutations were discovered. To analyze functional contribution of these unique germline mutations in tumor progression, these unique prevalent mutations in the evolutionary conserved regions of exonuclease and polymerase domains we generated by site directed mutagenesis and functional and tumorigenic analysis was performed. Results: We observed marked differences in copy number variation of POLG1 through cBioPortal and Cosmic databases and validated the analysis in primary tumors and cancer cell lines. Our results also indicate that mtDNA copy number in cancer cell is governed by regulation of POLG1 methylation and demethylation status, suggestive of epigenetic regulation of POLG1. We identified a mitochondrial disease causing missense variation in polymerase domain of POLG1 at amino acid 1143 (E1143G) to be 25 times more prevalent in European-Americans when compared to African-Americans population. Expression of this germline variant (E1143G) increased glucose consumption, decreased ATP production and increased matrigel invasion. Discussion\/ Conclusion: We demonstrate that POLG1 is epigenetically regulated and its unique germline variants contribute to disruption of mitochondrial function. Thus contributes to differences in increased predisposition to cancer in inter-ethnic population. Note: This abstract was not presented at the meeting. Citation Format: Prachi Bajpai, Bhupendra Singh, Kjerstin M. Owens, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Keshav K. Singh. Interethnic germline variants in mitochondrial DNA polymerase (POLG1) induce mitochondrial dysfunction and confer tumorigenic properties [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1494. doi:10.1158\/1538-7445.AM2017-1494","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":90246046,"openaccessinfo":{"externalids":{"MAG":"2741541343","ACL":null,"DOI":"10.1158\/1538-7445.AM2017-1494","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"GaN nanowires (NWs) doped with Mg as a p-type impurity were grown on Si(111) substrates by plasma-assisted molecular beam epitaxy. In a systematic series of experiments, the amount of Mg supplied during NW growth was varied. The incorporation of Mg into the NWs was confirmed by the observation of donor-acceptor pairs and acceptor-bound excitons in low-temperature photoluminescence spectroscopy. Quantitative information about the Mg concentrations was deduced from Raman scattering by local vibrational modes related to Mg. In order to study the type and density of charge carriers present in the NWs, we employed two photoelectrochemical techniques, open-circuit potential and Mott-Schottky measurements. Both methods showed the expected transition from n-type to p-type conductivity with increasing Mg doping level, and the latter characterization technique allowed us to quantify the charge carrier concentration. Beyond the quantitative information obtained for Mg doping of GaN NWs, our systematic and comprehensive investigation demonstrates the benefit of photoelectrochemical methods for the analysis of doping in semiconductor NWs in general.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":34266179,"openaccessinfo":{"externalids":{"MAG":"2586285215","ACL":null,"DOI":"10.1021\/acs.nanolett.6b04560","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Mimosa ophthalmocentra Mart ex Benth (Jurema de embira) and Abelmoschus esculentus Linn (okra), are used without treatment of cough, bronchitis, inflammations, infections and as cicatrization. Proof of the use of medicinal plants is necessary to define patterns of composition of their origins. Carry out a characterization of plant drugs obtained from Mimosa ophthalmocentra and Abelmoschus esculentus and to preliminarily evaluate the safety of use. As leaves of M. oftalmocentra and the fruits of A. esculentus were collected, dehydrated, pulverized and separated in different size of pieces. The mineral composition performed by X-ray fluorescence spectrometer. The centesimal composition was performed by the methods suggested by Adolfo Lutz Institute. The physical-chemical characterization and fingerprinting performed by thermo-analytical (TG, DTA and CG \/ MS-Pir) and phytochemical analyzes (Polyphenols, Flavonoids and Tannins). The biological study was evaluated by pharmacological screening, lethal dose determination, Abnormal Contortion Test and hemolysis. The mineral analyzes showed a calcium content of approximately 66%, followed by the elements K, Cl, S, Fe, Mg, P, Si and Mn in a lower concentration. The centesimal composition showed about 60% carbohydrates, 2 to 9% lipids and approximately 16% proteins. Thermal data and pyrograms were significant in the analyzed vegetables. The biological analyzes suggest low toxicity of both plants under study and a possible antinoceptive and antiinflammatory action of M. ophthalmocentra.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":216738328,"openaccessinfo":{"externalids":{"MAG":"2994696258","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We introduce the Aria Digital Twin (ADT) - an egocentric dataset captured using Aria glasses with extensive object, environment, and human level ground truth. This ADT release contains 200 sequences of real-world activities conducted by Aria wearers in two real indoor scenes with 398 object instances (324 stationary and 74 dynamic). Each sequence consists of: a) raw data of two monochrome camera streams, one RGB camera stream, two IMU streams; b) complete sensor calibration; c) ground truth data including continuous 6-degree-of-freedom (6DoF) poses of the Aria devices, object 6DoF poses, 3D eye gaze vectors, 3D human poses, 2D image segmentations, image depth maps; and d) photo-realistic synthetic renderings. To the best of our knowledge, there is no existing egocentric dataset with a level of accuracy, photo-realism and comprehensiveness comparable to ADT. By contributing ADT to the research community, our mission is to set a new standard for evaluation in the egocentric machine perception domain, which includes very challenging research problems such as 3D object detection and tracking, scene reconstruction and understanding, sim-to-real learning, human pose prediction - while also inspiring new machine perception tasks for augmented reality (AR) applications. To kick start exploration of the ADT research use cases, we evaluated several existing state-of-the-art methods for object detection, segmentation and image translation tasks that demonstrate the usefulness of ADT as a benchmarking dataset.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":259137475,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2306.06362","PubMedCentral":null,"ArXiv":"2306.06362"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this study, a numerical analysis framework for investigating the nonlinear behavior of structures under fire conditions is presented. In particular, analysis procedure combining fire-driven flow simulation and thermo-mechanical analysis is discussed to investigate the mechanical behavior of fire-exposed representative volume structures made of steel and concrete, respectively. First of all, fire-driven flow analysis is conducted using Fire Dynamics Simulator(FDS) in a rectangular parallelepiped domain containing the structure. The FDS simulation yields the time history of temperature on the surface of the structure under fire conditions. Second, mechanical responses of the fire-exposed structure with respect to prescribed uniformly distributed loads are calculated by a coupled thermo-mechanical analysis using the time-varying surface temperature as boundary conditions. Material nonlinearities of steel and concrete have been considered in the thermo-mechanical analysis. A series of numerical results are presented to demonstrate the feasibility of the multiphysics structural fire analysis for investigating the structural behavior under fire conditions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":114144227,"openaccessinfo":{"externalids":{"MAG":"2519422188","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We tested the hypothesis that the pericardium, by restricting heart size, limits maximal cardiac output and oxygen consumption. We studied 15 pigs. Five underwent maximal treadmill running before and 14-21 days after thoracotomy and pericardiectomy; these pigs also received sequential volume infusions to determine end-diastolic pressure-dimension relationships. Five underwent maximal treadmill running before and 14-21 days after thoracotomy (pericardium undisturbed) to determine the effect of thoracotomy on exercise performance. Finally, five underwent thoracotomy, instrumentation, loose closure of the pericardium, and sequential volume infusions to determine the effect of thoracotomy without pericardiectomy on end-diastolic pressure-dimension relationships. Pericardiectomy caused similar increases in maximal cardiac output (29% increase; P = 0.007) and maximal oxygen consumption (31% increase; P = 0.02). These results were associated with increased left ventricular end-diastolic dimension (10% increase; P = 0.01) and an estimated 33% increase in end-diastolic volume. In addition, left ventricular mass was increased by pericardiectomy (18% increase; P < 0.04). Thus the pericardium, by limiting utilization of the Starling mechanism, limits maximal cardiac output, and the limit to cardiorespiratory performance lies not in oxygen utilization, but in oxygen delivery. Furthermore, removal of pericardium is associated with myocardial hypertrophy.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":7244770,"openaccessinfo":{"externalids":{"MAG":"1921228756","ACL":null,"DOI":"10.1152\/AJPHEART.1992.263.6.H1675","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PRIDNYA, M. V. AND V. V. CHERPAKOV (Caucasus State Biosphere Preserve, Sochi, Russia) AND F L. PAILLET (U.S. Geological Survey, MS 403, Box 25046, Federal Center, Denver, CO 80225). Ecology and pathology of European chestnut (Castanea sativa) in the deciduous forests of the Caucasus Mountains in southern Russia. Bull. Torrey Bot. Club 123: 213-222. 1996.-Chestnut-dominated forests of the Caucasus Mountain area of Russia are very similar to former chestnut-dominated forests in eastern North America. The distribution, pathology, and reproductive status of European chestnut (Castanea sativa) in the Caucasus are described and compared to that of American chestnut (C. dentata). Chestnut forests are distributed continuously along the southern slope of the Caucasus mountains near the Black Sea, and are found in isolated populations on the north side of the Caucasus, at elevations ranging from 200 to 1300 meters. Chestnut blight was apparently introduced into the region after 1880 and continues to destroy chestnut forests today. Chestnut in the Caucasus is also infected by several other fungal and bacterial parasites and the joint infection of blight and bacteria may be especially dangerous for chestnut trees. Chestnut-dominated forests comprise only a few percent of total forest cover in the Caucasus Biosphere Preserve, and usually occur in mountain valleys or coves with deep brown soil. The age structure and reproductive status of chestnut in the Caucasus was investigated on six study plots in the Caucasus Biosphere Forest Preserve near the upper altitudinal limit of chestnut. Although chestnut is at least 70 percent of the overstory on these sites, there are very few trees less than 50 years old, and very few recent seedlings on any of the plots. Most large chestnut trees appear to have originated as basal spouts from previously established stems. Although chestnut seed production appears adequate, we suspect that competition with shrubs and other tree seedlings, and predation by herbivores and rodents, now prevent the establishment and survival of chestnut seedlings in the Biosphere Preserve.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":81920253,"openaccessinfo":{"externalids":{"MAG":"2797508070","ACL":null,"DOI":"10.2307\/2996797","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"We study a mesoscopic superconducting ring threaded by a magnetic flux when the single-particle level spacing is not negligible. It is shown that, for a superconducting ring with even parity, the behavior of persistent current is equivalent to what is expected in a bulk superconducting ring. On the other hand, we find that a ring with odd parity shows anomalous behavior such as fluxoid quantization at half-integral multiples of the flux quantum and paramagnetic response at low temperature. We also discuss how the parity effect in the persistent current disappears as the temperature is raised or the size of the ring increases.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":250852684,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1209\/epl\/i2000-00529-8","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/arxiv.org\/pdf\/cond-mat\/0005347","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Horse liver alcohol dehydrogenase (HLADH) has been found to be a versatile biocatalyst for the desymmetrization of prochiral 3\u2010arylpentane\u20101,5\u2010diols, based on a two\u2010step one\u2010pot oxidation. This procedure has allowed the formation of valuable (S)\u2010lactones in good to excellent conversions and enantiomeric excess. The catalytic performance of HLADH has been studied using several cofactor regeneration systems and cosolvents, finding great improvements in terms of activity with L\u2010lactate dehydrogenase, while the stereoselectivity of the process was significantly improved when using tetrahydrofuran. Docking studies has revealed the pattern substitution importance in the selectivity and activity of this oxidative process.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":53954150,"openaccessinfo":{"externalids":{"MAG":"2015409696","ACL":null,"DOI":"10.1002\/cctc.201300640","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1002\/cctc.201300640","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Real-time volumetric particle tracking velocimetry (VPTV) equipped with field-programmable gate array (FPGA) cameras has been used for open-space, low particle density, and large-scale airflow measurements with long measurement periods. However, the particle detection accuracy of FPGA cameras is inevitably hindered by non-uniform illumination, resulting in a reduction in the particle detection ratio and positional accuracy. In this article, we propose to use both synchronized FPGA and grayscale cameras in a VPTV system, where grayscale cameras utilize a new algorithm based on two-frame centroid and corner extraction (TFCCE) under non-uniform white-light illumination. To keep the frame rate of the FPGA cameras the same, the TFCCE algorithm was accelerated by a graphics processing unit (GPU). The simulation results showed that the 2D particle detection ratio of TFCCE was enhanced to approximately 80% with a positional accuracy of 0.57 pixels, compared to 30% and 0.94 pixels for the single-frame centroid extraction used in the FPGA. The GPU version of TFCCE was 15.09 times faster than the CPU version, resulting in a calculation time of 4.55 ms per image, compared to 68.70 ms when using the CPU. This system was also validated by the measurement of a turbulent jet flow in real-time at 120 fps. The experimental results correspond well with data published in the literature. Therefore, this new algorithm can improve VPTV systems in terms of particle detection ratio and positional accuracy in real time under conditions of non-uniform illumination.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":235602806,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1088\/1361-6501\/ac000a","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The present study was conducted in the Division of Plant Physiology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu to evaluate the effect of zinc and boron fortification on yield and quality in chickpea variety GNG-1958. Foliar application of boron and zinc were applied at different concentration with treatment T1-Control, T2-Zn (0.5%), T3 - Zn (1.5%), T4-B (0.5%), T5-B (1.0%), T6-Zn (0.5%) B (0.5%), T7-Zn (0.5%) B (1%), T8-Zn (1%) B (0.5%), T9-Zn (1%) B (1%), T10-Zn (1.5%) B (0.5%) and T11-Zn (1.5%) B (1%). Maximum plant height was recorded in T6 (32.33 cm) in comparison to control (22.80 cm). Highest chlorophyll content was observed in T6 (2.56 mg\/g) and lowest was found in control (1.18 mg\/g). Maximum grain zinc and boron content were recorded in T6 (43.63 mg\/Kg), (40.55 mg\/Kg) and minimum were observed in control (39.42 mg\/Kg) and (35.99 mg\/Kg) respectively. The highest harvest index was found in T6 (33.11%) and lowest in control (30.01%). Foliar application of Zn (0.5%) + B (0.5%) combination were found best for quantitative yield and quality production of chickpea crop.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-10":1,"2024-26":1}},"corpusid":262686651,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Neural systems face the challenge of optimizing their performance with limited resources, just as economic systems do. Here, we use tools of neoclassical economic theory to explore how a frugal visual system should use a limited number of neurons to optimize perception of motion. The theory prescribes that vision should allocate its resources to different conditions of stimulation according to the degree of balance between measurement uncertainties and stimulus uncertainties. We find that human vision approximately follows the optimal prescription. The equilibrium theory explains why human visual sensitivity is distributed the way it is and why qualitatively different regimes of apparent motion are observed at different speeds. The theory offers a new normative framework for understanding the mechanisms of visual sensitivity at the threshold of visibility and above the threshold and predicts large-scale changes in visual sensitivity in response to changes in the statistics of stimulation and system goals.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":15646104,"openaccessinfo":{"externalids":{"MAG":"1993027036","ACL":null,"DOI":"10.1167\/7.8.8","PubMedCentral":null,"ArXiv":null},"license":"CCBYNCND","url":"https:\/\/doi.org\/10.1167\/7.8.8","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Dynamic co-regulation of the actin and microtubule subsystems enables the highly precise and adaptive remodeling of the cytoskeleton necessary for critical cellular processes, like axonal pathfinding. The modes and mediators of this interpolymer crosstalk, however, are inadequately understood. We identify Fmn2, a non-diaphanous related formin associated with cognitive disabilities, as a novel regulator of cooperative actin-microtubule remodeling in growth cones. We show that Fmn2 stabilizes microtubules in the growth cones of cultured spinal neurons and also in vivo. Superresolution imaging revealed that Fmn2 facilitates guidance of exploratory microtubules along actin bundles into the chemosensory filopodia. Using live imaging, biochemistry and single-molecule assays we show that a C-terminal domain in Fmn2 is necessary for the dynamic association between microtubules and actin filaments. In the absence of the cross-bridging function of Fmn2, filopodial capture of microtubules is compromised resulting in de-stabilized filopodial protrusions and deficits in growth cone chemotaxis. Our results uncover a critical function for Fmn2 in actin-microtubule crosstalk in neurons and demonstrate that modulating microtubule dynamics via associations with F-actin is central to directional motility. SIGNIFICANCE STATEMENT The formin family member, Fmn2, is associated with cognitive impairment and neurodegenerative conditions though its function in neurons is poorly characterized. We report a novel actin-microtubule cross-bridging activity for Fmn2 that facilitates efficient targeting and capture of microtubules in growth cone filopodia. This activity is necessary for accurate pathfinding of axons and may contribute to Fmn2-associated neuropathologies. The precision and adaptability of cytoskeleton-driven processes are intimately dependent on the coupled activities of its component systems. Our study identifies a novel modality of co-regulated remodelling of the actin and microtubule cytoskeletons that facilitate critical cellular behaviour like neuronal chemotaxis.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":236452802,"openaccessinfo":{"externalids":{"MAG":"2999704345","ACL":null,"DOI":"10.1101\/2020.01.18.911131","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"https:\/\/www.biorxiv.org\/content\/biorxiv\/early\/2020\/01\/18\/2020.01.18.911131.full.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"In Reply. \u2014Dr Viader and colleagues point out in their letter the neglect observed with two cases of right posterior capsular infarction. They distinguish between attentional and intentional neglect and consider their cases attentional in contrast to ours. This is difficult to judge from such a short description. For instance, no distinction is apparent between purely visually controlled or verbally controlled activity in their cases. Our patients had no tactile or auditory extinction in contrast to theirs, and they improved on verbal cues and instructions, indicating an intentional rather than attentional disturbance, even though this distinction is subject to interpretation.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":146141434,"openaccessinfo":{"externalids":{"MAG":"2158618413","ACL":null,"DOI":"10.1001\/ARCHNEUR.1985.04060050018004","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"LSI will have a profound effect on the design of computer systems ranging from evolutionary changes in implementation to revolutionary changes in basic architecture. This paper discusses a computer composed of an array of processors. Entire wafers are used, rather than wafers diced into chips. The computer utilizes software to substitute process elements for the purpose of compensating for imperfect yield on the wafer. The computer organization possesses a property called block orientation which permits the use of whole LSI wafers with low yields without requiring a secondary metalization manufacturing step. Through the use of a unique computing algorithm, the parallelism and communication problems inherent to array processors are minimized. Processing systems of the sort discussed can possess a self-healing capability.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":30088671,"openaccessinfo":{"externalids":{"MAG":"2004049658","ACL":null,"DOI":"10.1109\/T-C.1969.222753","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Brachial Plexus Injury (BPI) Service at the Victoria Infirmary, Glasgow is a designated National Service for Scotland. The aim of this service is \"to provide specialist multidisciplinary integrated management for assessment, surgical reconstruction and rehabilitation for patients with brachial plexus injury\". To date more than 150 patients have been referred to the clinic. The National Centre for Prosthetics and Orthotics (NCPO) has provided orthotic support to the clinic since its initiation. This paper presents the results of a detailed review the orthotic provision through this service. A systematic review of the clinical notes of every patient fitted with a Brachial Plexus Orthosis (BPO) was carried out. The information gathered included; the demographic profile of the patient group, nature of the original injury, corrective surgery carried out, Disabilities of the Arm, Shoulder and Hand (DASH) Score and the orthotic prescription. A number of studies (1, 2) have sought to utilise the DASH Score to indicate the effectiveness of interventions for a number of upper-limb conditions, including BPI. Initial findings in this study indicate the potential effectiveness of this tool when prescribing and reviewing a BPO. However, further work is required before definitive guidelines may be produced.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":68516661,"openaccessinfo":{"externalids":{"MAG":"184007226","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background:\u00a0Garlic, or Allium savitum, has long been used to treat various diseases, including cancer. The anticancer effects of garlic are linked to the several garlic-derived organosulfur compounds, such as allicin, ajoene, DAS, DADS, DATS, and SAMC. Animal and in vitro studies have demonstrated that garlic bioactive compounds may prevent cancer through mechanisms such as inducing cell cycle arrest, promoting apoptosis, and inhibiting angiogenesis in different cancer cells. Observational studies, including case-control and cohort studies, have been conducted to confirm the protective effect against colorectal, gastric, and other cancers associated with garlic-derived bioactive compounds and raw garlic consumption, but results have been mixed. Analysis of cell and animal model studies and epidemiological studies using the FDA's evidence-based review system for health claims and FFC's proposed standard for evaluating and developing functional food, it has been concluded that garlic cannot yet be considered as a functional food primarily due to the inconclusive data from observational studies and insufficient evidence from randomized clinical trials.\u00a0Keywords: Garlic, cancer, allicin, bioactive compound, functional food","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":55957343,"openaccessinfo":{"externalids":{"MAG":"2885838927","ACL":null,"DOI":"10.31989\/BCHD.V1I2.530","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Objective: to identify the knowledge of community health agents (CHA) of the city of Passo Fundo on crack and other drugs and to describe their sociodemographic and health profiles. Methods: descriptive study with 78 CHA from Passo Fundo. Data collection occurred through the application of a structured and self-administered questionnaire on demographics and health of CHA, and another on knowledge about crack and other drugs. Descriptive analysis and Tukeys test, as well as Pearsons product moment correlation and Spearmans correlation were performed. Results: all CHA were female, mean age 41.1\u00b19.6 years, with 57.7% of them having completed high school and 69.2% being married. Also, 11.5% were smokers, 93.6% denied alcohol dependence and most had drug addicts in their coverage area. Half of them presented family problems. In relation to health, 29.5% obtained an SRQ score suggesting the possibility of Common Mental Disorders, and 51.3% said that they had chronic diseases. In the knowledge test the average of correct answers was 34.5%, with the highest number of correct answers being among the CHA with more schooling (p = 0.006). Conclusion: the low number of correct answers on the knowledge test shows an urgent need to strengthen the training of CHA. The specific profile of these professionals raises the need for more attention to their health, as well as new research in the area.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":74852029,"openaccessinfo":{"externalids":{"MAG":"2308319295","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Synthetic aperture radar (SAR) images of Taylor Valley, Antarctica, were acquired in January 1999 in coordination with ground-based measurements to assess SAR detection of the snowline on dry polar glaciers. We expected significant penetration of the radar wave resulting in an offset of the SAR-detected snowline relative to the true snowline. Results indicated no detectable displacement of the SAR snowline. Snow depths of 15 cm over ice can be detected on the imagery. We hypothesize that the optical depth of thin snowpacks is enhanced by reflection and refraction of the radar beam by internal snow layers. The enhanced optical depth increases the volume scattering, and thereby enhances backscatter sufficiently to be detected by the SAR. Consequently, SAR imagery may be used directly to image the position of transient snowlines in dry polar regions.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":140588212,"openaccessinfo":{"externalids":{"MAG":"2031759902","ACL":null,"DOI":"10.3189\/172756402781818021","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.3189\/172756402781818021","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The current-induced effective field in perpendicularly magnetized Ta\/CoFeB\/MgO wire was investigated. A threshold field decrease of 6.4 kOe\/mA was observed by measuring the threshold field of Hall resistance versus the magnetic field curve with various bias currents. The decrease was probably caused by the in-plane effective field, mainly due to the Rashba effect. The effective field of the Ta\/CoFeB\/MgO wire was smaller and opposite in direction compared to that of Pt\/Co\/AlOx previously reported.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-10":1}},"corpusid":121883312,"openaccessinfo":{"externalids":{"MAG":"2011901356","ACL":null,"DOI":"10.1063\/1.3579155","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Introduction The two week-wait pathway for suspected colorectal cancer (CRC2ww) ensures prompt review and investigation of patients with symptoms concerning for malignancy. Previous investigation of such patients does not preclude future repeat referral yet may not represent efficient use of limited clinic time or diagnostic services. This study aims to evaluate the incidence and outcome of repeat CRC2ww referrals. Methods A retrospective review of all CRC2ww referrals to our unit over a 4-year period was conducted. Patients with previous CRC2ww referrals were identified from a hospital database. Referral indication and outcome for all referrals was collected. Results 2731 CRC2ww referrals were made between July 2007 and July 2011, median age 72 (19\u2013102), 1179 (43%) male. 273 cancers were identified including 212 colorectal cancers. 121 referrals were repeat referrals, with 77 made prior to July 2007, and a median 1087.5 (35\u20132709) days between initial and repeat referrals. Referral indication was the same in 55 (47%) cases. When compared to unique referrals, repeat referral were associated with increased age (79\u2005years vs 71\u2005years, p<0.0001) and increased proportion of females (69% vs 56%, p=0.0048). Six cancers, including two CRC, were identified following repeat referral with a median 1511.5 (477\u20131988) days between initial and repeat referrals. There was no statistical difference in cancer detection between unique or repeat referrals (5.2% vs 10.4%, p=0.07). Conclusion Repeat referrals comprise a small proportion of all CRC2ww referrals. Such patients are older and more commonly female. However, cancer detection is not significantly lower in this cohort when compared to those not previously referred. Historical referral or investigation should not preclude future CRC2ww referrals and such patients should be investigated to the same extent as unique referrals. Competing interests None declared.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":72841605,"openaccessinfo":{"externalids":{"MAG":"2053783349","ACL":null,"DOI":"10.1136\/gutjnl-2012-302514d.100","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/gut.bmj.com\/content\/gutjnl\/61\/Suppl_2\/A337.2.full.pdf","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT Understanding mating behavioral sequence helps us identify the mechanisms of mate assessment and choice, and better evaluate behavior-based pest control strategies. Here we describe the mating behavior of Cnephasia jactatana Walker whose females release a sex pheromone, and determine the effect of male mating status on reproductive success. The mating sequence starts when males approach females and display courtship behavior with antennation and fanning wings. Both males and females may end a mating attempt at any stage of the sequence. Both sexes assess their mates from the initial contact to copulation. Females appear to be choosier at the early and mid-stages than at the late stage of the sequence. Virgin males approach and court females significantly earlier than nonvirgin males. As compared with nonvirgin males, virgin males are \u22481.6 times more likely to approach and 1.8 times more likely to court females, and four times more likely to achieve mating. This may be attributed to depletion of sperm and accessory gland materials and reduced ability to respond to female sex pheromones in nonvirgin males. The number of attempts by males to acquire mates may be one of the traits that females assess before choosing their mates.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":30431575,"openaccessinfo":{"externalids":{"MAG":"2164166692","ACL":null,"DOI":"10.1603\/EC12210","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract 1906 Reactivation of latent viruses such as cytomegalovirus (CMV) and adenovirus (AdV) is responsible for infections which may be life-threatening in HSCT recipients. In the post-transplantation period, severity and frequency of these infections depend on (a) the degree of donor-recipient HLA incompatibility and (b) the intensity of immunosuppressive therapy used to prevent immunological complications. Antiviral drugs may be partially effective, often toxic and cannot always control those viral infections.T cell immunity plays a major role in the control of viral infections. It has been demonstrated that the transfer of donor T lymphocytes specifically directed against viral antigens is capable of preventing, controlling and clearing viral infection (Feuchtinger T et al., 2004 and 2010). The present project aimed the evaluation of specific, cell-based immunity against CMV and AdV by injection of IFN-g-positive CD4+and CD8+ donor T lymphocytes isolated ex vivo after stimulation with viral peptides. Methods: Our protocol was designed for pediatric or adult patients treated by allogeneic HSCT and matching the following inclusion criteria: (1) biological and\/or clinical symptoms of CMV and\/or AdV infection 2) no response or contraindication to conventional antiviral treatment and (3) no or low grade pre-existing aGvHD at inclusion (\u2264 grade II) controlled by corticoids ( Donor IFN-g-positive T lymphocytes are isolated with the CliniMACS Cytokine Capture System (Miltenyi Biotech) after incubation with viral peptide pools. Primary evaluation criterion is the efficacy of the treatment on CMV viral load 21 days after the first injection. In the event of a negative or partial response and the absence of aGvHD, a second injection may be scheduled. Secondary evaluation criteria are (1) the occurrence of de novo aGvHD or aggravation of existing aGvHD, (2) the evolution of clinical symptoms potentially related to the infection, (3) the demonstration of biological in vivo expansion of injected T lymphocytes (as evidenced by the IFN-g secretion capacity and specific tetramer assays) and (4) for AdV infection, evaluation of efficacy (viral load, in vivo expansion of transfused lymphocytes, clinical symptoms) and the safety (occurrence of aGvHD) of this immunotherapy. Results: From September 2010 to July 2012, 9 patients were included: 3 male adults (46\u201354 years, 1 CLL, 1 CML and 1 AA, 2 geno- and 1 pheno-identical transplantation) and 6 children (age: 7\u201325 months, sex ratio F\/M: 4\/2, 4 FLH, 1 SCID and 1AA, 4 haplo, 1 geno- and 1 pheno-id transplantation). 4\/9 patients were treated for CMV, 3\/9 for AdV and 2\/9 for CMV and AdV reactivation. 5\/9 patients received 2 cytotoxic T lymphocytes (CTL) injections. Mean number of CD3 IFN-g positive cells injected was 4206\/kg (1167\u20136000\/kg) with 55% and 69% of CD4 and CD8 anti CMV-T cells and 56% and 61% of CD4 and CD8 anti AdV T cells respectively. Mean delay of first immunotherapy was 109 days (28\u2013270) after transplantation. 2\/9 patients were not evaluable due to early death ( Conclusion: The CliniMACS Cytokine Capture System allows the isolation of virus-specific T cells in a brief delay (24 hours) with a satisfactory enrichment of both CD4 and CD8 T cells. First results show efficacy of virus-specific T cells injection on viral load without signs of aGvHD in 5\/6 evaluable patients. More patients need to be included in this trial in order to confirm these encouraging results. Disclosures: Cambouris:Miltenyi Biotec: Employment.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":79305542,"openaccessinfo":{"externalids":{"MAG":"2585144062","ACL":null,"DOI":"10.1182\/BLOOD.V120.21.1906.1906","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract: In most of the educational institutions, the significant amount of energy is spent for illuminating the classrooms and for switching the fans, computers and so on. Sometimes due to unnecessary consumption of energy the energy costs may rise. practices. In order to minimise the energy consumption or to avoid energy waste during unoccupied and daylight hours ,here more efficient equipment is designed for utilization of improved lighting design Here we have established a lighting control system in which the light circuits and fans in classroom remain Off in the absence of students and switches on in their presence. When student enter classroom , Infrared energy emitted from the person activates the IR sensor and the aurdino acts as power saving device according to relay operations. By using IR Sensor is detected the relays are triggered and the fan and lights are switched On. Measuring the brightness of the cl motion LDR Sensor for assroom and also a sensor is used for the measuring the temperature, if the temperature is above 25\u00b0C the fans will be turned ON.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":259721396,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.22214\/ijraset.2023.54489","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.22214\/ijraset.2023.54489","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Using eLearning technology today in education is changing the way in which knowledge is introduced, stored and distributed, accordingly; knowledge management technologies is used to rapidly capture, organize and deliver large amounts of new knowledge. BA as a shared context in eLearning environment requires students to share, construct and utilize knowledge through knowledge creation processes as proposed in Nonaka's model of knowledge creation (SECI). This research aims to introduce and prove that eLearning environments supports the knowledge processes and creates conditions which are consistent with Nonaka's model of knowledge creation (SECI) and the concept of BA as a shared context for knowledge creation processes and activities, a research model was built and hypotheses were formed to reflect it, then a survey was distributed between the students of Syrian Virtual University (SVU) to collect the primary data to discover the strength of relationships between the model variables, The results demonstrates that BA as a shared context affects positively knowledge creation model (SECI) in the mediation of eLearning environment. This research is a consolidated contribution to field of eLearning by engaging knowledge management concepts in the whole process of it.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":2}},"corpusid":209550549,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract In this study, we developed an intermodal transportation model that extends the VRP model and its recovery model. This study emphasizes re-identifying the best route, departure time, and the selection of the best ship with the right type of capacity booking that produces the lowest total cost after dealing with disruption. The re-routing process is shifted by transforming the disruption to a virtual node in order to define the added time and cost after a disruption occurred. The disruption types include link and customer disruptions. The numerical experiment uses the metaheuristics, namely, Genetic Algorithm and Simulated Annealing, because it is an np-hard problem. The results of the optimization process yielded the total cost increased when the average vehicle speed was enhanced. The starting service time provides cost savings through a reduction of penalties because the arrival is not within the time window that had been agreed upon. Besides, the type of capacity order, more specifically the type of direct purchase (on the spot), provides better costs when the level of disruption is heavy. In contrast, a lighter level of disruption can cause a minimal total cost for purchasing the up-front type of fee. However, the scenario of capacity cost shows that lower prices can make the direct purchasing type more profitable. On the other hand, increasing the price of renting a ship's capacity makes the up-front type of fees more profitable.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":225210679,"openaccessinfo":{"externalids":{"MAG":"3080443962","ACL":null,"DOI":"10.1080\/23311916.2020.1805156","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/23311916.2020.1805156?needAccess=true","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"There are patterns buried within the mass of data in the various editions of population census figures in this country. These are patterns that will be impossible for humans working with bare eyes and hands, to uncover without computer system to give geo-spatial distribution of population in that area. This paper is an effort towards harnessing the power of data-mining technique to develop mining model applicable to the analysis of census data that could uncover some hidden patterns to get their geo-spatial distribution. This could help better-informed business decisions and provide government with the intelligence for strategic planning, tactical decision-making and better policy formulation. Decision tree learning is a method for approximating discrete-valued target function, in which the leaned function is represented by a decision tree. Decision tree algorithm was used to predict some basic attributes of population in the census database. Structured System Analysis and Design Methodology were used.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":28426779,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.9790\/0661-1420105","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.9790\/0661-1420105","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Demographic trends in Spain from 1860 to 1930 are analyzed using data from official sources. The author notes that, although the birth and death rates declined, the population continued to grow over the period. The impact of large-scale emigration on population characteristics and spatial distribution is discussed. (SUMMARY IN ENG)","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":36765432,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Literature on agglomeration economies firmly establishes the trinity of Input sharing, Labour pooling, and Knowledge spillover, originally conceived by Alfred Marshal, as the foundation of any industrial agglomeration or cluster. Acknowledging the rationale of the trinity, this paper documents the pieces of evidence of Input sharing and Labour pooling in a planned automobile cluster of Pithampur, a backward region of the state of Madhya Pradesh in India. The development of the automobile cluster has transformed Pithampur from a bunch of villages to an automobile hub of central India. Knowledge spillover has been kept out of this study due to the paucity of data. These pieces of evidence are collected through primary and secondary data. It is found from the pieces of evidence of input sharing that both union and state government have played a significant role in developing industry-related infrastructures in Pithampur. The availability of supporting infrastructure, services and various fiscal incentives has helped the firms enjoy economies of scale and attracts potential investors to establish their firms in Pithampur. The evidences of labour pooling capture the dramatic changes in the demography of Pithampur in terms of population growth, sex ratio, occupational shift, migration, etc.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":253561728,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.53894\/ijirss.v5i4.958","PubMedCentral":null,"ArXiv":null},"license":"CCBYNC","url":"http:\/\/www.ijirss.com\/index.php\/ijirss\/article\/download\/958\/304","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"Shoppers have been queuing up to vote for their favourite independent retailer with over 400 votes being cast so far.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":107418127,"openaccessinfo":{"externalids":{"MAG":"92697368","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A poly(2-(9H-carbazol-9-yl) acetic acid) thin-film was formed on the surface of a platinum (Pt) electrode by oxidative electropolymerization of a new carbazole derivative. Electrochemical polymerization was performed in reaction medium containing monomer and 0.1 M TBABF4 mixture in acetonitrile (ACN) using repeated cycling at a scanning rate of 250 mV. The electrochemical polymerization of 2-(9H-carbazol-9-yl) acetic acid (25mM) was studied using cyclic voltammetry on both Pt and ITO electrodes. The structure of the soluble polymer was elucidated by nuclear magnetic resonance (1H and 13CNMR) and Fourier transform infrared (FTIR) spectroscopy. The weight average molecular weight of poly(2-(9H-carbazol-9-yl) acetic acid) was determined using gel permeation chromatography (GPC) and found to be 130900 g\/mol. Characterizations of the resulting polymer were performed by cyclic voltammetry, dry conductivity measurement and scanning electron microscopy (SEM), while the UV-Visible spectroscopy and electrochemical spectroscopic studies indicated that the poly(2-(9H-carbazol-9-yl) acetic acid) film showed a green color in the oxidized state, and high transmittance in the neutral state. Moreover, the poly(2-(9H-carbazol-9-yl) acetic acid) film is soluble in common organic solvents, such as DMSO, THF, NMP, and DMAC. The conductivities of poly(2-(9H-carbazol-9-yl) acetic acid) is about 4.3x 10-2 S\/cm.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":246769055,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.9734\/ajacr\/2021\/v10i230234","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.9734\/ajacr\/2021\/v10i230234","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"ABSTRACT In addition to threonine auxotrophy, mutation of the Saccharomyces cerevisiae threonine biosynthetic genes THR1 (encoding homoserine kinase) and THR4 (encoding threonine synthase) results in a plethora of other phenotypes. We investigated the basis for these other phenotypes and found that they are dependent on the toxic biosynthetic intermediate homoserine. Moreover, homoserine is also toxic for Candida albicansthr1\u0394 mutants. Since increasing levels of threonine, but not other amino acids, overcome the homoserine toxicity of thr1\u0394 mutants, homoserine may act as a toxic threonine analog. Homoserine-mediated lethality of thr1\u0394 mutants is blocked by cycloheximide, consistent with a role for protein synthesis in this lethality. We identified various proteasome and ubiquitin pathway components that either when mutated or present in high copy numbers suppressed the thr1\u0394 mutant homoserine toxicity. Since the doa4\u0394 and proteasome mutants identified have reduced ubiquitin- and\/or proteasome-mediated proteolysis, the degradation of a particular protein or subset of proteins likely contributes to homoserine toxicity.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2013-20":1}},"corpusid":30798077,"openaccessinfo":{"externalids":{"MAG":"2153069806","ACL":null,"DOI":"10.1128\/EC.00044-10","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Although the power output of today's wind turbine has exceeded 7 MW, the voltage rating of the most common generator is below 700 V. A low-frequency transformer is commonly used to step-up the voltage to the grid voltage level, e.g. 11 kV or 33 kV. These heavy and bulky low-frequency transformers significantly increase the volume and weight of nacelle. To achieve a compact and light nacelle, a medium-voltage converter with series-connected H-bridge (SCHB) topology would be an attractive technology for future wind turbines. However, the SCHB converter requires multiple isolated and balanced DC sources, which makes the application not straightforward. As an alternative approach to generate multiple isolated and balanced sources a prototype transformer with six secondary windings, 1.26 kVA and 10 kHz, is designed and developed for 1 kV five levels SCHB multilevel converters. The experimental results show that the proposed system may be attractive in grid based renewable energy systems.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":41798391,"openaccessinfo":{"externalids":{"MAG":"2097704497","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Over the last 50 years, Nepal has been considered an experiential model in determining the effectiveness and success of global human development strategies, both in theory and in practice. As such, it provides a rich array of in-depth case studies in both development success and failure. This edited collection examines these in order to propose a novel perspective on how human development occurs and how it can be aided and sustained.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":115644122,"openaccessinfo":{"externalids":{"MAG":"2743214943","ACL":null,"DOI":"10.4324\/9781315621630","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Abstract Owing to the toxicity of lead, much effort has been put in studies on lead-free solders after environmental legislations prohibited the use of lead in these parts worldwide. Here, Bi\u2013Ag and Bi\u2013Sb alternative solder alloys containing 1\u00b75\u20135 wt-% Ag and Sb were investigated. The effect of the reflow number and weight percentage of Ag and Sb on the surface properties of solders and interfacial reactions between the solder bulk and the Cu substrate were analysed by optical microscopy and scanning electron microscopy\u2013energy dispersive X-ray. The results show that by increasing the reflow number and wt-% of Ag and Sb in the solder bulk, the thickness of the mechanical grain boundary grooving is increased. However, the thickness of the Cu3Sb intermetallic compound layer at the interface of Bi\u20135Sb decreased by increasing the reflow number. Moreover, our findings show that the amount of Ag and Sb in solder alloys and the reflow number have different behaviours on the wettability properties. By increasing the reflow number, the wetting angle decreased in Bi\u2013Ag solder alloys, whereas it increased in Bi\u2013Sb solder alloys.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":136622325,"openaccessinfo":{"externalids":{"MAG":"1995932353","ACL":null,"DOI":"10.1179\/1432891714Z.000000000976","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones were prepared from 5-hydroxy isatin. A mixture of 5-hydroxy isatin, dialkylamino alkylhalide in alcoholic potassium hydroxide was stirred at room temperature for 6 hours to get the 5-[2(3)dialkylamino alkoxy] Indole 2,3-diones. The structures of the products were characterized by IR, NMR, MASS Spectral studies. All the compounds were examined for antioxidant activity by using 1, 1-diphenyl-2-picryl-hydrazyl and hydrogen peroxide (H2O2), and the total antioxidant capacity by a phosphomolybdenum assay. In general, the derivatives were found to exhibit antioxidant activity. Further, the compounds with dialkylamino alkoxy at the C5 position demonstrated significant antioxidant activity.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":2387869,"openaccessinfo":{"externalids":{"MAG":"2184051972","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Reliable and cost-effective early-life stage (ELS) bioassays incorporating practical experimentation without compromising scientific relevance are crucial in chemical risk assessment. This study investigated the use of 20 days-post-fertilization life stage (20dpfZF) of zebrafishDanio rerio to screen environmental chemicals known to be estrogenicin adult fish. Firstly, studies with key genes in steroidogenesis were conducted; the brain isoform of aromatase gene (cyp19a1b) being the most prominently expressed biomarker. Regulation of mRNA levels of molecular biomarkers, vitellogenin 1 gene (vtg1) and cyp19a1b were selected to assess the endocrine modulation by xenoestrogens, 17\u03b1-ethinylestradiol (EE2), 4-n-nonylphenol (NP), 4-t-octylphenol (OP) and bisphenol A (BPA). Groups of 20dpfZF (n=15) as three replicates were exposed to chemicals over a five-day period in aerated static setups. Exposure of 20dpfZF to sediment spiked with EE2 (nominal 3\u03bcg g-1dw) was also conducted to assess the sensitivity of this life-stage to sediment with estrogenic potency. Whole body homogenates of exposed juveniles showed the estrogenic potential of chemicals in the order: EE2 > OP > BPA > NP. Higher relative expression of cyp19a1b was noticed at lower ambient concentrations of EE2, although vtg1 showed more pronounced expression to it. The 20dpfZF responded in a dose-related way to sediment spiked with EE2, expanding its use as a general aquatic animal model. The suitability of 20dpfZF as an in vivo model, along with stable expression of reference genes was established. In addition to consistent expression pattern of key target genes on xenoestrogenicity, it serves as a practical screening model for the risk assessment of environmental chemicals and samples with estrogenic potential.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":13719338,"openaccessinfo":{"externalids":{"MAG":"2324183545","ACL":null,"DOI":"10.4172\/2161-0525.1000202","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.4172\/2161-0525.1000202","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"The purpose of this study was to evaluate the respiratory morbidity status within the two to three years among successful (completed\/cured) treatment of tuberculosis cases during a haze year (2015) and a post-haze year (2016). The study was conducted among 133 cases of a 2015 group and 103 cases of a 2016 group between January to March 2018 in Pekanbaru city, Indonesia. The St George Respiratory Questionnaire (SGRQ) was used to assess respiratory morbidity status. A higher score corresponds to worse respiratory morbidity. Based on a directed acyclic graph, quantile regression models were constructed to assess the associations between haze\/post-haze year and the SGRQ (symptom, activity, impact, and total) domains score. The subsequent respiratory morbidity status of tuberculosis (TB) cases was poorer among respondents treated during a haze year (2015). Among SGRQ domains, only the activity domain score showed significant difference, in which the median for the 2015 group was 23.7 (inter-quartile range (IQR); 17.2, 30.9) compared to 18.4 (IQR; 11.9, 24.8) for the 2016 group. The effect was limited to the 2015 group who were exposed by an average PM10 index \u2265 55 during TB treatment. This raises concern for monitoring and improving the quality of life of TB patients treated during a haze year.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":208318371,"openaccessinfo":{"externalids":{"MAG":"2991277909","ACL":null,"DOI":"10.3390\/ijerph16234669","PubMedCentral":"6926855","ArXiv":null},"license":null,"url":"https:\/\/www.mdpi.com\/1660-4601\/16\/23\/4669\/pdf?version=1574487069","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Long Term Evolution (LTE) is consents pliable spectrum distribution which renders enriched wireless data services to users at lower latency and multi-megabit throughput. LTE uses Orthogonal Frequency Division Multiple Access (OFDMA) and Single Carrier Frequency Division Multiple Access (Sc-FDMA) for downlink and Uplink transmission where OFDMA has been acquired in LTE for downlink transmission which diminishes the terminal cost and power consumption and Sc-FDMA has been allocates multiple users to a shared communication resources. Frequency Division Duplex (FDD) and Time Division Duplex (TDD) are the prevailing duplexing scheme in LTE that provides deployable tractability according to spectrum assignation. In this paper, we analyze the performance of SC-FDMA and OFDMA in LTE Frame Structure based on Peak to Average Power Ratio (PAPR) analysis. ITU Pedestrian A channel and ITU Vehicular A channel and also Additive White Gaussian Noise (AWGN) channel are used for analyzing the error performance between SC-FDMA and OFDMA. General Terms LTE, SNR, minimum BER, AWGN, FDD, TDD","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":16245216,"openaccessinfo":{"externalids":{"MAG":"2106377425","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Lymphocytes from individuals with laboratory evidence of prior infection with herpes simplex virus (HSV) type 1 or type 2 demonstrated transformation (av antigens. Higher stimulation indexes were obtained when lymphocytes were incubated with the homologous as compared with the heterologous antigen. Higher mean lymphocyte stimulation indexes were also demonstrated in seropositive as compared with seronegative individuals. Lymphocytes from children with HSV-1 stomatitis usually became responsive to HSV-1 antigen within 2 to 6 weeks after the onset of illness. Lymphocytes from infants with neonatal HSV-2 infection were stimulated by HSV-2 antigen.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":30876402,"openaccessinfo":{"externalids":{"MAG":"1915772376","ACL":null,"DOI":"10.1128\/iai.11.1.109-112.1975","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.1128\/iai.11.1.109-112.1975","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"This paper investigates firms' decisions to reimburse consumers' switching costs in network industries. Prior literature finds that switching costs incentivize firms to harvest their locked-in consumers rather than price aggressively for market dominance, resulting in a lower market concentration. Using a dynamic duopoly model, we show that this result is reversed if firms have the option to reimburse consumers' switching costs. In that case the larger firm offers a bigger reimbursement to switching consumers than the smaller firm does, as an additional instrument to propel itself to market dominance. Consequently, an increase in switching cost increases market concentration. Compared to the case without reimbursements, allowing firms the option to reimburse results in greater consumer welfare despite having a much higher market concentration. Consumers' benefits from a larger network and switching cost reimbursement outweigh the higher price charged by a dominant firm.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":21567326,"openaccessinfo":{"externalids":{"MAG":"2566809351","ACL":null,"DOI":"10.2139\/ssrn.2848553","PubMedCentral":null,"ArXiv":null},"license":null,"url":"http:\/\/www.netinst.org\/Chen_16-13.pdf","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Indonesia is a disaster-prone region facing multiple hazards. The impact has cost human casualties, injuries, damages to assets, environment and regional development. In order to protect the people and assets, the government has increased the capacity to face and anticipate disaster which is through a multi-hazard early warning system (MHEWS). The academic sector in Indonesia, especially prominent universities such as Institut Teknologi Bandung and Universitas Gajah Mada has contributed positively to the development of MHEWS and the Land Slide Early Warning System. This research aims to examine the role of universities in Indonesia related to the establishment of an MHEWS in Indonesia by answering what are the roles and the challenges. The research methodology is through a desk study and document review of government and organizations reports using qualitative and descriptive analysis. The findings of the research indicate the role of universities in the MHEWS is in line with the concept of tri dharma of universities which research, higher education and outreach. This means the role of universities to conduct research related to early warning systems, higher education through having program studies related to disaster management and outreach the role to train the community, organizations, and government through professional networks. Unfortunately, the involvement of the eastern part of Indonesian universities still needs to increase capacity, awareness, and access in utilizing the MHEWS at the local level.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":169584979,"openaccessinfo":{"externalids":{"MAG":"2900924787","ACL":null,"DOI":"10.1051\/matecconf\/201822902018","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.1051\/matecconf\/201822902018","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Big Data is control. Consider Technological \"watching\" (veillance). Whether it is lists of banned books, files and interrogation reports on arrested people, or algorithms searching massive databases, it isn't about voyeurism, but instrumentalist power. Established distinctions between data, information, and knowledge from computer science are a helpful sorting device for understanding why some forms of Big Data are more effective for control than others. Political struggles and corporate hype over veillance Big Data obscures how unuseful it has been so far, and how different \"data\" of any sort is from actionable information (intelligence). Even then, action doesn't promise effectiveness. Affordances, agency, network architectures, semantics and the political economy determine effective communication and control. Thls is clear from the role of Big Data in neuroscience, which is making great instrumentalist progress. Specific, rigorous knowledge is much more powerful, and dangerous, than data of any size or information, no matter its origin.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":59965162,"openaccessinfo":{"externalids":{"MAG":"252312409","ACL":null,"DOI":"10.5209\/REV_TK.2016.V13.N1.52452","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"PurposeThis study has two main objectives: (1) to expand the application areas of grey system theory and (2) to select the most livable city in Turkey.Design\/methodology\/approachChoosing the most livable city is a complex problem that requires many criteria to be considered. It is important to select decision points according to which the criteria selection will be made and to what extent the criteria will affect the evaluation. For this purpose, a questionnaire was prepared to determine the criteria to be used in the assessment. The survey results were evaluated by the factor analysis (FA) and it was found that the criteria included in the survey were grouped under seven factors. Then, criteria weights were assigned to the determined criteria using the analytic hierarchy process (AHP). At the last stage, Turkey's six most popular cities are graded using the grey relational analysis (GRA) to reduce the uncertainty existing in the process of evaluation.FindingsThe obtained results indicated that the most livable city in Turkey is Istanbul. Istanbul is followed by Izmir, Antalya, Eskisehir, Bursa and Ankara, respectively. Considering that Istanbul is a center of attraction in many respects, this result is not a surprise for many people. It is also observed that the results obtained overlap with similar studies in the literature.Originality\/valueGrey system theory and grey numbers have not been previously used to select the most livable city. With this aspect, this study has expanded the application of grey system theory and made an important contribution to the literature.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":225097240,"openaccessinfo":{"externalids":{"MAG":"3034216958","ACL":null,"DOI":"10.1108\/gs-04-2020-0042","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract The increase in multidrug resistance among colon cancer cells presents a challenge for the development of effective therapies. Small-molecule analogues of second mitochondria-derived activator of caspase (SMAC) mimetic in association with mixed lineage kinase domain-like protein (MLKL)-pDNA and z-VAD-fmk have shown ideal antitumor effects in colon cancer cells in vitro via induction of RIP3-dependent necroptosis. To achieve synergistic antitumor effects in vivo, liposomes loaded with SMAC mimetic, MLKL-pDNA and z-VAD-fmk have been developed using novel lipid fusion methods to co-localise the molecules of interest within the tumour cells. The co-encapsulation liposome (MLKL-zVAD-BV6-LP) had a high entrapment efficiency of approximately 95% for both zVAD and BV6 and was able to condense MLKL-pDNA very well. The vectors showed good biocompatibility, tumour targeting and small-molecule co-localisation. In a CT26 mouse model, the MLKL-zVAD-BV6-LP exhibited a tumour-suppression rate of over 60% in vivo, which was significantly higher than that of both the null-liposome and coadministration groups. Above all, the co-encapsulation system provided a novel approach to combination tumour therapy.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3446969,"openaccessinfo":{"externalids":{"MAG":"2703726914","ACL":null,"DOI":"10.1080\/1061186X.2017.1339192","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The results shown that there are some differences in overall job stress level of permanent employees in private and public sector banks, results founded the public sector banks' employees significantly affected more by stress due to no control on their jobs, social unsupported by the mangers, and mechanistic and strict organizational structure than the private sector bank's employees. This article highlights comparative study on stress management in public and private sector banks in Nagapattinam district, Tamilnadu","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":168211293,"openaccessinfo":{"externalids":{"MAG":"2569071318","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Supreme Court in Roe v. Wade framed the abortion right as the right to make an abortion decision in consultation with a \"responsible physician.\" Under this framing, doctors were cast into the role of medical \"gatekeepers\" to mediate patient access to abortion. In the ensuing years, the doctorpatient relationship has become the site of restrictive abortion regulations in many states. This Article argues that Roe's framing suffers from a foundational flaw: while the gatekeeper framing may have been appropriate in the Roe era when abortion was surgical and non-clinical abortions were potentially lethal, today, medication abortion-a two-drug non-surgical regimen that can safely and effectively terminate a pregnancy at home-renders the Court's gatekeeper framing obsolete and no longer reflects the technological or medical realities of abortion-related healthcare. This Article reasserts the constitutional right to abortion and argues that advances in medical technology call for a new framing for the right as one of direct access to abortion that is not dependent upon the provider-patient relationship. This framing is better suited to protect the breadth and depth of the abortion right because it reflects the new technological realities of the practice of abortion and the promise of abortion care outside of the medical gatekeeper model, which has been the focus of restrictive regulation and clinic harassment. It is a critical time to re-examine the gatekeeper framing of the abortion right considering the dramatic conservative shift in the Supreme Court that threatens Roe, and in the midst of a pandemic, which-in a complete reversal of the Roe period- renders in-person care by a provider potentially dangerous. In January, the Supreme Court's first abortion decision since President Trump's appointment of three justices, FDA v. American College of Obstetricians & Gynecologists (\"ACOG\"), doubled down on the medical gatekeeper model by reinstating an FDA requirement that medication abortion pills must be dispensed in person by a provider. Re-examining the historical, social, and technological assumptions that animate the current framing of the abortion right is vital to thinking of new ways to frame and expand abortion access. Today's online medical and pharmaceutical marketplaces reveal that the Court's confined vision of the abortion right was informed by the social and technological realities of its time-social and technological realities that no longer exist. If Roe's cramped vision of the abortion right has run its course, as I argue here, then the movement to protect access to abortion must include direct consumer access to abortion. Empirical evidence reveals widespread use of self-managed medication abortion in the face of abortion restrictions. The shuttering of clinics as \"non-essential services\" during the COVID-19 pandemic and the unnecessary increased risk of clinic-based care for procedures that can be safely managed at home only amplify the need for direct-to-consumer access to abortion care. As state legislatures seek to make it easier to prosecute individuals suspected of terminating their own pregnancies, it is a crucial moment to reconsider the constitutional foundation of the abortion right and the right to self-managed care as a matter of criminal and reproductive justice and public health.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":246824939,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The free electron laser with a linearly polarized wiggler and axial guide field hag been studied. A relativistio, cold electron beam passes through a parallel-plate waveguide in these magnetic fields. The spontaneous emission coefficient and the dispersion equation of the stimulated Raman emission of the transverse electric wave (TE mode) in the electron beam reference-frame are calculated. It's growth rate is given. When the cyclotron frequency of the electron is equal to the frequency of the pump wave in the electron beam reference-frame, the intensities of both the spontaneous and stimulated emissions increase sharply due to the resonance.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":124447992,"openaccessinfo":{"externalids":{"MAG":"2369587995","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": Objective We propose a strategy for identifying subgroups with the treatment effect from the survival data of a randomized clinical trial based on accelerated failure time (AFT) model. Methods We applied adaptive elastic net to the AFT model (designated as the penalized model) and identified the candidate covariates based on covariate-treatment interactions. To classify the patient subgroups, we utilized a likelihood-based change-point algorithm to determine the threshold cutoff point. A two-stage adaptive design was adopted to verify if the treatment effect existed within the identified subgroups. Results The penalized model with the main effect of the covariates considerably outperformed the univariate model without the main effect for the trial data with a small sample size, a high censoring rate, a small subgroup size, or a sample size that did not exceed the number of covariates; in other scenarios, the latter model showed better performances. Compared with the traditional design, the adaptive design improved the power for detecting the treatment effect where subgroup effect exists with a well-controlled type I error. Conclusion The penalized AFT model with the main effect of the covariates has advantages in subgroup identification from the survival data of clinical trials. Compared with the traditional design, the two-stage adaptive design has better performance in evaluation of the treatment effect when a subgroup effect exists. failure","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":249952751,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":": The installation of photovoltaic (PV) system for electrical power generation has gained a substantial interest in the power system for clean and green energy. However, having the intermittent characteristics of photovoltaic, its integration with the power system may cause certain uncertainties (voltage fluctuations, harmonics in output waveforms, etc.) leading towards reliability and stability issues. In PV systems, the power electronics play a significant role in energy harvesting and integration of grid-friendly power systems. Therefore, the reliability, efficiency, and cost-effectiveness of power converters are of main concern in the system design and are mainly dependent on the applied control strategy. This review article presents a comprehensive review on the grid-connected PV systems. A wide spectrum of different classifications and configurations of grid-connected inverters is presented. Different multi-level inverter topologies along with the modulation techniques are classified into many types and are elaborated in detail. Moreover, different control reference frames used in inverters are presented. In addition, different control strategies applied to inverters are discussed and a concise summary of the related literature review is presented in tabulated form. Finally, the scope of the research is briefly discussed.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":264746096,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper studies the Mach number effect on cruise performance for a 2D Co-Flow Jet (CFJ) airfoil at freestream Mach number of 0.15, 0.30, 0.46 and 0.5. The optimized 2D CFJ airfoil, CFJ6421-SST150-SUC247INJ117 is redesigned by enlarging the size of the injection and suction slot from the CFJ airfoil previously designed by Lefebvre and Zha. The results show that the best CFJ airfoil corrected aerodynamic efficiency ((CL\/CD)c) occurs at M\u221e of 0.30, which produces a (CL\/CD)c of 81.04 at C\u03bc of 0.03 and AoA of 6 \u25e6. The case at M\u221e of 0.30 has higher compressibility than that at M\u221e of 0.15, but is still far from the sonic speed. The favorable conditions hence provide the optimum aerodynamic efficiency. At the same C\u03bc and AoA, the maximum Mach number on the CFJ airfoil suction surface at M\u221e of 0.15, 0.30, 0.46, 0.50 is 0.264, 0.558, 1.025 and 1.289 respectively. For the case of M\u221e of 0.50, the flow becomes transonic. As the M\u221e increases, the CL is also increased due to the stronger compressibility effect that creates a greater suction effect. At M\u221e of 0.46, which is the critical Mach number for the airfoil at AoA of 6\u25e6, the corrected aerodynamic efficiency is still very good. But when the M\u221e is increased to 0.5, the optimum aerodynamic efficiency occurs at a lower AoA and C\u03bc with AoA = 2 \u25e6 and C\u03bc = 0.01. Under this condition, the flow remain subsonic without shock wave. For the optimum cruise condition with the Mach number varying from 0.15 to 0.5, the ratio of the injection jet velocity to the freestream velocity is varied from 1.24 to 0.68, and the total pressure ratio between the injection and suction slot is from 1.02 to 1.20. The low CFJ jet velocity is beneficial to reduce the noise and the low total pressure ratio is beneficial to achieve the low power requirement at cruise. Comparing the optimum efficiency point of the baseline NACA 6421 airfoil and CFJ airfoil, the CFJ airfoil improves the lift coefficient by 30%. The aerodynamic efficiency is improved by 60% or more (under 100% pump efficiency) and 40% or more (under 70% pump efficiency). This paper also studies two control laws for cruise control of the CFJ airfoil when the AoA varies: One is to achieve constant injection momentum coefficient, the other is to achieve constant injection total pressure. The latter is preferred for its easier sensor measurement, higher airfoil efficiency, and higher stall AoA. The numerical simulations employ the intensively validated in house FASIP CFD code, which utilizes a 3D RANS solver with Spalart-Allmaras (S-A) turbulence model, 3rd order WENO scheme for the inviscid fluxes, and 2nd order central differencing for the viscous terms.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":195817272,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.2514\/6.2019-3169","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Fault tree analysis (FTA) is frequently applied to deductively evaluate the safety systems of complex engineering systems such as chemical industries or nuclear facilities. To perform this analysis, generic data are commonly used due to the limitation of historical failure data of the system being evaluated. However, generic data have a degree of uncertainty and hence cannot represent the system's actual performance. In addition, generic data are not applicable to older components due to the aging process, which obviously degrades the reliability of those components. To deal with this limitation, another safety analysis method, called fuzzy fault tree analysis (FFTA), has been proposed. The purpose of this study is to apply FFTA to evaluate the performance of the primary cooling systems of G.A. Siwabessy Multipurpose Reactor (RSG-GAS). RSG-GAS is a research reactor, which belongs to the National Nuclear Energy Agency of Indonesia (BATAN). Expert justifications were used to evaluate the failure occurrences of basic events in the primary cooling system of the RSG\u2013GAS through questionnaires. The assessment by experts is in the form of qualitative data, which are then converted into quantitative data by applying FFTA. Then, the top event probability generated from FFTA was applied to calculate the event probability using event tree analysis (ETA). It was obtained that the highest event probability was 4.304 \u00d7 10\u22128\/year. Since it complies with The International Atomic Energy Agency (IAEA) specified core damage frequency (CDF) limit, i.e., not greater than 10\u22125\/year of reactor operation, the reactor is safe to operate.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":218813799,"openaccessinfo":{"externalids":{"MAG":"3017030263","ACL":null,"DOI":"10.3390\/en13081975","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/www.mdpi.com\/1996-1073\/13\/8\/1975\/pdf?version=1588040047","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"With the extensive use of wireless devices within or at close proximity to the human body, electromagnetic effects caused by the interaction between RF waves and human tissues need to be considered with paramount importance. The ultra-wideband (UWB) communication spectrum has recently been utilized in bio-telemetry applications, such as neural recording, brain-computer interfaces, and physiological data monitoring requiring high data rate and low power. This paper reports the electromagnetic effects of head-implantable transmitting devices operating based on impulse radio UWB wireless technology. Simulations illustrate the performance of an implantable UWB antenna tuned to operate at 4 GHz with an -10-dB bandwidth of approximately 1 GHz when it is implanted in a human head model. Specific absorption rate (SAR), specific absorption (SA), and temperature increase are analyzed to compare the compliance of the transmitting device with international safety regulations. The frequency- and age-dependent nature of the tissue properties, such as relative permittivity, is taken into account. The SAR\/SA variation of the human head is presented with varying input power, different antenna orientations, and different signal bandwidths. We also present the percentage of SAR variation for each tissue type in the head model used for the simulations.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":15820708,"openaccessinfo":{"externalids":{"MAG":"2065761052","ACL":null,"DOI":"10.1109\/TMTT.2013.2250515","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"A unique and extensive test grout program, with both stage and stop-grouted holes on 5-ft centers, was conducted in fractured and solutioned dolomite at the Meramec Park Lake damsite, Sullivan, Missouri. Pre-grouting and postgrouting pumping tests from water wells completely surrounded by a 50-ft square grout curtain provided quantitative data on the amount of seepage actually occurring through a completed grout curtain. A 97 percent reduction in the specific capacity of the test well after grouting showed that grouting is a positive method of reducing groundwater flow. Optimum grout take was achieved using thin mixes of neat cement with a small amount of bentonite injected at a total pressure of 1f times foot of depth. Grout take was not influenced by hole diameter. Grout movement was joint controlled, and most grout injected did not spread more than 5 ft. Overcoring showed grout was penetrating all openings around hole perimeters. Test results showed that criteria developed to indicate the relative effectiveness of grouting do provide a real method to assess the quality of grouting.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":129646021,"openaccessinfo":{"externalids":{"MAG":"1985650442","ACL":null,"DOI":"10.2113\/gseegeosci.xix.1.15","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Triple Play is a technology that integrating various applications on telecommunication network, broadcast network, and the Internet. This technology can be implemented by wiring or wireless transmission. Therefore, in this paper, we firstly focuses on exploring how to use the existing power grid to achieve Triple Play via Power Line (TPPL) and finally proves its feasibility in the experimental project that conducted in two buildings.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":44291628,"openaccessinfo":{"externalids":{"MAG":"2129587905","ACL":null,"DOI":"10.1109\/ISPLC.2012.6201284","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The ability to measure and age individuals within a population has many important applications, for example, for examining growth and determining size class. We developed a simple photogrammetric system using two parallel lasers and a digital camera, in order to measure dorsal fin dimensions of free-ranging Hector's dolphins. Laser dots were projected onto the fin, providing scale, thus allowing measurement as well as simultaneous photo-ID of 34 individuals from fin nicks and other marks. Multiple measurements (\u22655) were available for six individuals; these resulted in mean CVs of 3.71% for fin length and 3.76% for fin height. Errors due to variations in angle and measurement were quantified via photography of a fiberglass Hector's dolphin model. Allometric measurements and age data were collated from 233 autopsied Hector's dolphins. Using these data, fin length was found to be a better predictor of total length (females r2= 0.732, males r2= 0.678) than fin height. Gompertz age\/length growth curves were fitted to these individuals. Linear regressions were used to estimate total length for 34 individuals from laser-metrically estimated fin base length. Individuals were then assigned one of three age categories. This system shows promise as a noninvasive way of measuring individuals, while allowing simultaneous photographic identification.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":85415347,"openaccessinfo":{"externalids":{"MAG":"2075143240","ACL":null,"DOI":"10.1111\/J.1748-7692.2009.00326.X","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We developed an improved method for the isolation of transcriptionally active nuclei from Saccharomyces cerevisiae, which allows analysis of specific transcripts. When incubated with alpha-32P-labeled ribonucleoside triphosphates in vitro, nuclei isolated from haploid or diploid cells transcribed rRNA, tRNA, and mRNAs in a strand-specific manner, as shown by slot blot hybridization of the in vitro synthesized RNA to cloned genes encoding 5.8S, 18S and 28S rRNAs, tRNATyr, and GAL7, URA3, TY1 and HIS3 mRNAs. A yeast strain containing a high-copy-number plasmid which overproduced GAL7 mRNA was initially used to facilitate detection of a discrete message. We optimized conditions for the transcription of genes expressed by each of the three yeast nuclear RNA polymerases. Under optimal conditions, labeled transcripts could be detected from single-copy genes normally expressed at low levels in the cells (HIS3 and URA3). We determined that the alpha-amanitin sensitivity of transcript synthesis in the isolated nuclei paralleled the sensitivity of the corresponding purified RNA polymerases; in particular, mRNA synthesis was 50% sensitive to 1 microgram of alpha-amanitin per ml, establishing transcription of mRNA by RNA polymerase II.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":20520082,"openaccessinfo":{"externalids":{"MAG":"2128153719","ACL":null,"DOI":"10.1128\/mcb.6.5.1633-1639.1986","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc367690?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"We encountered a case of gastric cancer that was initially detected as a deep hemorrhagic ulcer without surrounding irregular elevation, followed by rapid protrusion in less than 1 month. Using endoscopic images in the follow-up study, we estimated the doubling time (DT) of this unusual tumor as 9.2 days. Since the doubling time of gastric cancer is generally fairly long due to exfoliation of many cancer cells into the gastric lumen, this cancer presented with extremely rapid growth. Besides, this case reinforces that follow-up study is important in terms of clinical management of ulcerative lesions.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":260131072,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVES: To investigate evidence of the efficacy of cognitive-behavioral therapy in the treatment of obese patients with binge eating disorder. METHOD: This review included clinical trials and meta-analyses published in all languages from January 1980 to February 2006. Studies assessing the efficacy of cognitive-behavioral therapy associated with medication, cognitive-behavioral therapy in self-help manuals, case reports or series and letters to editors were excluded. The following electronic databases were used: MEDLINE, PsycINFO, Embase, LILACS and Cochrane Library. Search strategies also included consulting the references of selected articles and chapters of specialized books. RESULTS: Two open and 15 controlled clinical trials were included. The primary outcome in most studies was binge eating. In general, the clinical trials suggest that cognitive-behavioral therapy results in significant improvement in binge eating and other psychopathological symptoms related to binge eating disorder. However, no substantial weight loss was reported. CONCLUSIONS: Available evidence suggests that cognitive-behavioral therapy is an effective intervention method for psychological aspects of binge eating disorder, although its efficacy in body weight reduction and long-term maintenance of results still needs further investigation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144254876,"openaccessinfo":{"externalids":{"MAG":"2518680841","ACL":null,"DOI":"10.1590\/S0101-81082007000100015","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Envisaging the Credit nonpayer is a risky task of Financial Industries like Banks. find out the defaulter before giving loan is a noteworthy and conflict-ridden task of the Bankers. Classification techniques are the superior choice for predictive analysis like finding the claimant, whether he\/she is a modest customer or a cheat. Defining the excellent classifier is a tough assignment for any industrialist like a banker. This gives consent to computer science researchers to drill down efficient research works through evaluating different classifiers and finding out the best classifier for such predictive problems. This research work scrutinizes the efficiency of different Tree Based Classifiers (Random Forest, REP Tree and J48 Classifiers) for the credit risk prediction and compares their robustness through various measures. German credit dataset has been taken and used to envisage the credit risk with the help of open source machine learning tool.","meta":{"dup_signals":{"dup_doc_count":3,"dup_dump_count":2,"dup_details":{"curated_sources":1,"2024-18":1,"2024-22":1}},"corpusid":59965714,"openaccessinfo":{"externalids":{"MAG":"312754782","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents a five-axis milling force model that can incorporate a variety of cutters and workpiece materials. The mechanistic model uses a discretized cutting edge to calculate an area of intersection which is multiplied by the specific cutting pressure to produce a force output along the primary cartesian coordinate system. By using an analytic description of the cutting edge with a non-specific cutter and workpiece intersection routine, a model was created that can describe a variety of cutting situations. Furthermore, a back propagation neural network is used to calibrate the model, providing robustness and scalability to the calibration process. Testing was performed on 1020 steel using various cutting parameters with a high speed steel two flute cutter and a tungsten carbide insert cutter. Furthermore, both linear cuts and a test die surface yielded good agreement between predicted and measured results.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":243973528,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1115\/imece2000-1906","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Musculoskeletal conditions occurring in individuals with human immunodeficiency virus infection are becoming increasingly well documented. Arthritis with features of Reiter's syndrome or psoriatic arthritis has been further studied; an association with HLA-B27 but not with HLA antigens chemically associated with psoriasis or psoriatic arthritis has been demonstrated. Human immunodeficiency virus has been identified in synovial fluid dendritic cells and in the synovium; immunohistochemical analysis is revealing the nature of the lymphocyte infiltrate in the synovium of affected individuals. Postmortem studies suggest that there may be histologic evidence of premature aging in clinically unaffected joints from patients with acquired immunodeficiency syndrome. Epidemiologic studies are needed to elucidate which rheumatic lesions occur as a direct consequence of human immunodeficiency infection and which may be chance associations.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":37757580,"openaccessinfo":{"externalids":{"MAG":"2084222559","ACL":null,"DOI":"10.1097\/00002281-199108000-00012","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Speaking of energy sources, we are referring in general to all the natural sourcesof energy available to man. In the constant struggles to overcome nature and changethe society, man has gradually deepened and broadened his scope of cognizance, aswell as his ability of utilization, of energy sources; while the more he has become able to utilize the natural sourees of energy,the stronger his material strength will grow in changing the world. Hence the history of\u00a0 the evolution of energy sourees and tat of the human society are invariably closely linked with each other.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":203516289,"openaccessinfo":{"externalids":{"MAG":"2366692054","ACL":null,"DOI":"10.1360\/YA1975-18-5-681","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper presents the description of an open arch itecture for the management of environmental content using Web Services. The Web Services techno logy can be effectively exploited for integrating o n ne hand the needs for dissemination of analytical data about environment, such as air, noise, traffic, et ., and on the other hand the needs of different users concern ing the accessibility requirements of their devices , distributed and heterogeneous systems, remote and m obile control access. The case study of this paper is based on the OASI (Environmental Observatory of Sou thern Switzerland) project that permits access to t he air, noise and traffic measures for Southern Switze rland. Other than through traditional web pages, th i access is also made possible thanks to the deployment of s oftware applications based on Web Services. To this aim, a number of Web Services are defined using the UML analisys and developed. They identify a) a group handling the air information, b) a group implementi ng the access to the noise information and c) a gro up implementing the access to the traffic information using the OASI's database. In addition, another gro up allows users to manage his\/her own information, e.g . -mail, OASI's news, user's group, etc. In conclu sion, the Web Services Technology could be a good solutio n for the management of environmental content becau se it provides open and mobile access to data, interop erability among different client-server nodes, easy extensibility for integrating any kind of device in to the system.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":73566761,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"State-of-the-art design methods for electric machines use published correlations of either power or torque with electromagnetic and current loading, available for different cooling approaches. However, the applicability of these correlations for electric machines used within hybrid electric vehicles, with their different degrees of integration into the overall system, is limited. Using an integrated starter generator and an electric rear axle drive as example case applications, we study the influences of the thermal environment within the hybrid electric vehicle application, i.e., heat sinks and sources external to the machine on the thermal design of the machines. We quantify these influences by scaling factors for the air-gap shear stress of the machine.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21841373,"openaccessinfo":{"externalids":{"MAG":"2571708071","ACL":null,"DOI":"10.1109\/TIA.2017.2656069","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"This paper aims to give an overview of the solar tower technology and its consequences along with a new concept of mini solar towers using Fresnel lens. Fresnel lens are used to concentrate the solar radiation falling on the aperture to a particular point. It contributes to update the economic status and technical status of molten salt solar tower technology. It has aspired to explain the solar power tower with an overview of energy, renewable energy, solar energy, solar photovoltaic, solar thermal and Fresnel Lenses. Key Words\u2013 ST-solar tower, Fresnel lens, concentrated collectors","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":2,"unknown":2}},"corpusid":237437269,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.47392\/irjash.2020.83","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/doi.org\/10.47392\/irjash.2020.83","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background: Active oxygen radicals as well as a variety of cytosolic protein tyrosine kinases play a role in the regulation of prostaglandin E2 (PGE2), a key inflammatory mediator, released by skin cells in response to irradiation with ultraviolet B light (UVB). Identification of chemical compounds that can interrupt such events may provide a basis for the development of potent anti-inflammatory agents. Objective: To investigate the effect of a novel genistein analog, 2,4,6-trihydroxy-\u03b1-p-methoxyphenylacetophenone, with antioxidant property (compound D-58), on UVB-induced inflammatory responses. Methods: Epidermal cell cultures were irradiated with UVB both in the presence and absence of compound D-58 and the PGE2 released in the medium was determined by ELISA. For in vivo studies, skin inflammation was induced in mice either by carrageenan challenge of the air pouch or by an acute exposure of skin to UVB radiation. The resulting inflammatory mediator release, skin edema and the histological changes of the skin were determined both in the presence and absence of compound D-58. Results: Compound D-58 treatment effectively inhibited the development of edema and histological changes in the skin of UVB-irradiated mice as well as the release of PGE2 in vitro as well as in vivo. Conclusion: Compound D-58 (2,4,6-trihydroxy-\u03b1-p-methoxyphenylacetophenone) has potent anti-inflammatory properties.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":85153437,"openaccessinfo":{"externalids":{"MAG":"2055252343","ACL":null,"DOI":"10.1159\/000051549","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The potential cytogenetic damage in offset printing workers was evaluated using sister chromatid exchanges (SCEs), chromosome aberrations (CAs) and micronuclei (MN) as biomarkers in peripheral lymphocytes of 26 volunteers (14 workers, 12 controls). The CA, SCE and MN frequency of offset printing workers was significantly higher than in their controls. The replication index (RI) was not affected while the mitotic index (MI) was affected most in the workers. It can be concluded from this study that chronic occupational exposure to printing dyes and thinner may lead to a slightly increased risk of genetic damage among offset printing workers. Copyright \u00a9 2005 John Wiley & Sons, Ltd.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29319082,"openaccessinfo":{"externalids":{"MAG":"2163063624","ACL":null,"DOI":"10.1002\/jat.1098","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"This study explores the application of self-supervised learning (SSL) to the task of motion forecasting, an area that has not yet been extensively investigated despite the widespread success of SSL in computer vision and natural language processing. To address this gap, we introduce Forecast-MAE, an extension of the mask autoencoders framework that is specifically designed for self-supervised learning of the motion forecasting task. Our approach includes a novel masking strategy that leverages the strong interconnections between agents' trajectories and road networks, involving complementary masking of agents' future or history trajectories and random masking of lane segments. Our experiments on the challenging Argoverse 2 motion forecasting benchmark show that Forecast-MAE, which utilizes standard Transformer blocks with minimal inductive bias, achieves competitive performance compared to state-of-the-art methods that rely on supervised learning and sophisticated designs. Moreover, it outperforms the previous self-supervised learning method by a significant margin. Code is available at https:\/\/github.com\/jchengai\/forecast-mae.","meta":{"dup_signals":{"dup_doc_count":2,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1}},"corpusid":261048954,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.48550\/arXiv.2308.09882","PubMedCentral":null,"ArXiv":"2308.09882"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"We modify Talagrand's generic chaining method to obtain upper bounds for all p-th moments of the supremum of a stochastic process. These bounds lead to an estimate for the upper tail of the supremum with optimal deviation parameters. We apply our procedure to improve and extend some known deviation inequalities for suprema of unbounded empirical processes and chaos processes. As an application we give a significantly simplified proof of the restricted isometry property of the subsampled discrete Fourier transform.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":2}},"corpusid":17596203,"openaccessinfo":{"externalids":{"MAG":"2119745496","ACL":null,"DOI":"10.1214\/EJP.V20-3760","PubMedCentral":null,"ArXiv":"1309.3522"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Pairing in the Phasmatodea is notable for its duration. The Indian stick insect Necroscia sparaxes may remain coupled for up to 79 days (a record for insects) and accounts of matings lasting days or weeks are commonplace (LeFeuvre 1939; Korboot 1961; Gangrade 1963; Gustafson 1966; Clark 1974). Intromission may occur only initially or intermittently. In either case, a substantial proportion of male time-investment is not spent in ejaculate transfer. In captivity, Diapheromera veliei and D. covilleae pair for 3 to 136 hours and the penis may be inserted and removed up to 9 times. The genitalia are not in contact for ca. 40% of this period, and attachment is maintained by a male clasping organ. According to the best current explanation, males remain with females when not actively engaged in insemination to guard against the introduction of rival ejaculates and so avoid sperm competition (the competition of sperm from 2 or more males for the fertilization of an ovum; Parker 1971, 1974). Male aggression for possession of mating females has been described in a variety of insects (Parker 1970). In the only account known to me of attempted mate theft by a stick insect, an intruding male Orxines macklotti made several futile efforts to engage his genitalia, climbed off and walked away (Robinson 1965). Also indicative of a passive defense was a congregation of Carausius alluaudi collected in the Seychelles Islands consisting of 6 males clasping a female's abdomen at various points (a seventh male was nearby) (Bolivar and Ferriero 1912). While sedentary guarding of the female might be typical, lack of any","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":144559797,"openaccessinfo":{"externalids":{"MAG":"2033561997","ACL":null,"DOI":"10.1155\/1978\/35784","PubMedCentral":null,"ArXiv":null},"license":"public-domain","url":"https:\/\/downloads.hindawi.com\/journals\/psyche\/1978\/035784.pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Seismic diffractions from small-scale discontinuities or inhomogeneities carry key geologic information and can provide high-resolution images of these objects. Because diffractions characterized by weak energy are easily masked by strong reflections, diffraction-enhancement processing is essential before subwavelength information detection. Therefore, we propose a novel diffraction-separation method that uses the Fourier-based geometric-mode decomposition (GMDF) algorithm to remove reflections and separate diffractions in the common-offset or poststack domain. The key idea of the proposed method is that in the frequency-wavenumber ( f- k) domain, strong reflections concentrate linearly along a certain dip direction, whereas weak diffractions are distributed over a wide range of wavenumbers owing to their variable dips in the time-space domain. The GMDF algorithm can effectively represent reflections with directional and linear geometric features by adaptively decomposing seismic data as a combination of the band-limited modes consisting of linear characteristics in the f- k domain. The alternating direction method of the multipliers algorithm is used to solve the GMDF optimization problem and obtain linear reflections. Because this method considers the energy sparsity property and linear geometric features of reflections in the f- k domain, kinematic and dynamic differences between reflections and diffractions are exploited to separate diffractions. Applied synthetic and field examples demonstrate the good performance of the proposed method in removing strong reflections and separating weak diffractions, providing interpreters with detailed structural and stratigraphic information.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":252750373,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1190\/geo2022-0049.1","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The Traffic Management Advisor (TMA) is an air traffic control automation system currently in use in seven Air Route Traffic Control Centers (ARTCCs) to enable time based metering to busy airports within their airspace. However, this system is limited to operation within a single ARTCC, within about a 200 nautical mile radius of the airport, and on relatively simple streams of traffic. The need for coordinated metering within a greater (300+ nautical mile) radius of an airport, on streams of traffic with significant branching, and across ARTCC boundaries, has been identified. Early tests revealed that TMA could not simply be scaled up to handle such a problem. Instead, a loosely coupled hierarchy of schedules, in which constraints from downstream schedules are passed upstream, is required. Such an architecture reduces the reliance on distant projections of arrival times, making schedules robust to changes in sequence and to additions of aircraft (such as aircraft departing inside the system s scheduling horizon). This architecture is also scaleable, easily reconfigurable, and can be networked together. As such, it can be adapted for use in any size or configuration of airspace and with any number of airports delivering restrictions. An implementation of this distributed scheduling architecture is currently undergoing testing in the TMA-Multi Center system. This paper describes the architecture and its motivation.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-26":1,"unknown":2}},"corpusid":18162721,"openaccessinfo":{"externalids":{"MAG":"1970090598","ACL":null,"DOI":"10.2514\/6.2003-6758","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Human aging is characterized by progressive functional decline that coincides with both increased morbidity and mortality. Aging affects every human being and only few individuals achieve longevity, a very special phenotype marked by extraordinary healthy aging. This thesis consists of three chapters; each one is devoted to a separate project that contributes to the growing body of knowledge about aging and longevity. The work required the compilation, management and analysis of diverse big data sets and the application of cutting-edge statistical and computational methods. \n \nChapter 1 - A functional genomics study was conducted in the potentially immortal freshwater polyp Hydra using body part-specific microarray and RNA sequencing data. The results revealed gene expression patterns that allow boundary maintenance during Hydra's continuous cell proliferation and tissue self-renewal. Furthermore, this study provided evidence for de-acetylation as a key mechanism underlying compartmentalization. Surprisingly, FoxO, which is known to substantially drive developmental processes and stem cell renewal in Hydra, did not seem to be affected by the acetylation status. \n \nChapter 2 - Long-lived individuals (LLI, >95 years of age) epitomize the healthy aging phenotype and are thought to carry beneficial genetic variants that predispose to human longevity. Despite extensive research efforts, only few of these genetic factors in LLI have been identified so far. In contrast to previous investigations which mainly focused on intronic variants, a genome-wide exome-based case-control study was performed. DNA samples of more than 1,200 German LLI, including 599 centenarians (\u2265100 years), and about 6,900 younger controls were used for single-variant and gene-based association analyses that yielded two new candidate longevity genes, fructosamine 3 kinase related protein (FN3KRP) and phosphoglycolate phosphatase (PGP). FN3KRP functions in the deglycation of proteins to restore their function, while PGP via controlling glycerol-3-phosphate levels affects both glucose and fat metabolism. Given the biological functions of the genes, their longevity-associations appear very plausible. \n \nChapter 3 - In recent years, the intestinal microbiome (GM) has increasingly gained attention in aging and longevity research. A 16S rRNA microbiome study was conducted using 1301 stool samples of healthy individuals (age range: 19 - 104 years) that were drawn from three cohorts. The aim was to investigate potential associations among GM composition, host genetics and environmental factors during aging. The GM composition changed with age, showing an increase of opportunistic pathogens that may generate an inflammatory environment in the gut. Age explained only ~1% of the inter-individual variation, whereas anthropometric measures, genetic background and dietary patterns together explained 20%. Strikingly, clear GM population stratification in terms of four enterotype-like clusters was observed, which were predominantly associated with dietary patterns. The correction for these clusters was shown to increase the comparability of findings from the different cohorts. In addition, the LLI showed a specific gut microbial pattern, which is in line with previously published reports. \n \nThe present work shows that a thorough bioinformatics expertise helps to address the complexity of the two phenotypes aging and longevity. One highlight of the thesis is the discovery of two new candidate longevity loci that, in view of the limited output of previous study approaches, enlarge the existing database.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-30":1,"unknown":3}},"corpusid":212877533,"openaccessinfo":{"externalids":{"MAG":"3002298747","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors earlier proposed an orthogonal-core type push-pull converter. The converter was constructed with a pair of orthogonal-cores whose primary sides were excited by square-wave choppers, and the converter had almost sinusoidal output current and high power factor. In this paper we report a photovoltaic power system using the push-pull converter. The test results obtained in the trial system indicate that the orthogonal-core type push-pull converter can be applicable to a practical photovoltaic power system. As another application, an orthogonal-core type push-pull parametric transformer is also described here. It was experimentally clarified that a low distorted input current and high input power factor are obtained in the push-pull parametric transformer.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":42589762,"openaccessinfo":{"externalids":{"MAG":"1993265341","ACL":null,"DOI":"10.1109\/TJMJ.1989.4564428","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"SIR,-Professor E Szabadi's editorial on thyroid dysfunction and affective illness raised the question of whether subclinical dysfunction of the thyroid has a role in affective illnesses.' Lithium is well recognised to affect thyroid hormones; cases of hypothyroidism and hyperthyroidism have been reported.2 Primary affective disorders may themselves have a role in the development of autoimmune thyroid disease. A recent study was designed to determine whether the development of autoimmune thyroid disease was due to lithium treatment or depressive illness.4 Three main groups were studied: a control group, patients receiving treatment other than lithium for depression, and patients receiving lithium for their manic depressive illness. All patients were clinically and biochemically euthyroid. The serum samples obtained were tested for thyroid microsomal and thyroglobulin antibodies. None of the controls were positive for thyroid antibodies, but 7-5% of the patients receiving treatment other than lithium for depression were positive for the antibodies. This, however, is not significantly high when compared with the incidence in the general population.' The patients receiving lithium for their manic depressive illness showed a greatly increased incidence of thyroid antibodies (20%), in keeping with results of other studies.' 6 The authors concluded that lithium treatment induces the formation of antibodies in susceptible people, which may lead to the development of thyroid disease in these patients. A larger study will be necessary to determine whether affective disorders alone play any part in the development of subclinical hypothyroidism.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":41016382,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1136\/bmj.302.6789.1403","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc1669477?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Three major water masses occur for all or part of the year within the shelf and slope region off southern Australia. A Leeuwin Current carries the warmest water mass of relatively low salinity into the region, principally along the shelf break as far east as 130oE. This water mass first enters the western end of the region in May, disappears from the eastern end after July and from the western end by September-October. A warm and very high salinity water mass is present in the central and eastern half of the Great Australian Bight for most of the year. This central Bight water mass drifts to the south-east and occupies much of the shelf and slope region east of 135oE., particularly in winter. A West Wind Drift cold water mass of lowest salinity is found throughout the year off the slope region of southern Australia and periodically intrudes into the shelf break, especially when the Leeuwin Current is weakly developed. The central Bight waters, which provide a second source of warm waters in the eastern half of the region, greatly complicate the interpretation from satellite imagery of warm waters in that region as being derived solely from the Leeuwin Current. Adequate salinity data and sea surface temperatures derived from satellite imagery are required to determine more accurately the eastward extent of the Leeuwin Current.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":85351102,"openaccessinfo":{"externalids":{"MAG":"2054605792","ACL":null,"DOI":"10.1071\/MF9860001","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Latent class analyses in patients with acute respiratory distress syndrome (ARDS) have identified \"hyper-inflammatory\" and \"hypo-inflammatory\" phenotypes with divergent clinical outcomes and treatment responses. ARDS phenotypes are defined using plasma biomarkers and clinical variables. It is currently unknown if these phenotypes have distinct pulmonary biology and if pre-clinical models of disease replicate the biology of either phenotype. Methods: 45 subjects with ARDS (Berlin Definition) and 5 mechanically ventilated controls were selected from cohorts of mechanically ventilated patients at UCSF and ZSFG. Patients with COVID-19 were excluded from this analysis. A 3-variable classifier model (plasma IL-8, protein C, and bicarbonate;Sinha 2020) was used to assign ARDS phenotypes. Tracheal aspirate (TA) RNA was analyzed using established bulk and single-cell sequencing pipelines (Langelier 2018, Sarma 2021). Differentially expressed (DE) genes were analyzed using Ingenuity Pathway Analysis (IPA). Microbial community composition was analyzed with vegan. Fgsea was used to test for enrichment of gene sets from experimental ARDS models in genes that were differentially expressed between each phenotype and mechanically ventilated controls. Results: Bulk RNA sequencing (RNAseq) was available from 29 subjects with hypoinflammatory ARDS and 10 subjects with hyperinflammatory ARDS. 2,777 genes were differentially expressed between ARDS phenotypes. IPA identified several candidate upstream regulators of gene expression in hyperinflammatory ARDS including IL6, TNF, IL17C, and interferons (Figure 1A). 2,953 genes were differentially expressed between hyperinflammatory ARDS and 5 ventilated controls;in contrast, only 243 genes were differentially expressed between hypoinflammatory ARDS and controls, suggesting gene expression in the hypoinflammatory phenotype was more heterogeneous. Gene sets from experimental models of acute lung injury were enriched in hyperinflammatory ARDS but not in hypoinflammatory ARDS (Figure 1B). Single cell RNA sequencing (scRNAseq) was available from 6 additional subjects with ARDS, of whom 3 had hyperinflammatory ARDS. 14,843 cells passed quality control filters. Hyperinflammatory ARDS subjects had a markedly higher burden of neutrophils (Figure 1C), including a cluster of stressed neutrophils expressing heat shock protein RNA that was not present in hypoinflammatory ARDS. Expression of a Th1 signature was higher in T cells from hyperinflammatory ARDS. Differential expression analysis in macrophages identified increased expression of genes associated with mortality in a previous study of ARDS patients (Morell 2019). Conclusions: The respiratory tract biology of ARDS phenotypes is distinct. Hyperinflammatory ARDS is characterized by neutrophilic inflammation with distinct immune cell polarization. Transcriptomic profiling identifies candidate preclinical disease models that replicate gene expression observed in hyperinflammatory ARDS.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":248620615,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.1164\/ajrccm-conference.2022.205.1_meetingabstracts.a5036","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"P-wave amplitudes for elastic K+ K- photoproduction on hydrogen near the phi(1020) resonance have been derived in an analytical form and a partial wave decomposition of the amplitudes has been performed. We discuss the high energy limit of the resulting amplitudes and compare two types of pomeron coupling to nucleons.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":118032103,"openaccessinfo":{"externalids":{"MAG":"2950193295","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":"hep-ph\/0304007"},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"From the realization that cell number homoeostasis is fundamental to the biology of all metazoans, and that deregulation of this process leads to human diseases, enormous interest has been devoted over the last two decades to map the requirements of cell death and cell survival. This effort has led to tangible progress, and we can now chart with reasonable accuracy complex signalling circuitries controlling cell-fate decisions. Some of this knowledge has translated into novel therapeutics, and the outcome of these strategies, especially in cancer, is eagerly awaited. However, the function of cell-death modifiers have considerably broadened over the last few years, and these molecules are increasingly recognized as arbiters of cellular homoeostasis, from cell division, to intracellular signalling to cellular adaptation. This panoply of functions is best exemplified by members of the IAP (inhibitor of apoptosis) gene family, molecules originally narrowly defined as endogenous caspase inhibitors, but now firmly positioned at the crossroads of multiple normal and transformed cellular responses.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":38379403,"openaccessinfo":{"externalids":{"MAG":"1971576831","ACL":null,"DOI":"10.1042\/BJ20100814","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Intellectual property and private international law' was one of the subjects discussed at the 18th International Congress of Comparative Law held in Washington (July 2010). This volume contains the General Report and 20 National Reports covering Canada, US, Japan, Korea, India and a number of European countries (Austria, France, Germany, UK, Spain etc). The General Report was prepared on the basis of National Reports. The national reporters not only describe the existing legal framework, but also provide answers to 12 hypothetical cases concerning international jurisdiction, choice-of-law and recognition and enforcement of foreign judgments in multi-state IP disputes. Based on their answers the main differences between legal systems as well as the shortcomings of the cross-border enforcement of IP rights are outlined in the General Report. The Reports in this volume analyze relevant court decisions as well as recent legislative proposals (such as the ALI, CLIP, Transparency, Waseda and Korean Principles). This book is therefore a significant contribution to the existing debate in the field and will be a valuable source of reference in shaping future developments in the cross-border enforcement of IP rights in a global context.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":155917096,"openaccessinfo":{"externalids":{"MAG":"2219907631","ACL":null,"DOI":"10.5040\/9781472566102","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"The influence of bilateral 20-minute carotid ischemia with reperfusion of various duration upon the activity of apoptotic processes in the neurons and glia cells of the cerebral cortex in the temporal lobe of rats has been studied. Bilateral carotid ischemia with one-hour reperjusion has been indicated to increase the location density of p53+-neurocytes in this region of the cerebral cortex, increases percentage and density of p53+-nerve cells and reduces the percentage and density of p53+-glia cells on the 12th day of the post-ischemic period. Ischemic-reperfusion lesion of the brain increases the concentration of p53 protein in glia cells of the cerebral cortex in the temporal region in the early ischemic-reperfusion period and reduces it in nerve and glia cells in the late one.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":22841009,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"It is almost impossible to \"prove\" discrimination in the labor market, yet most would acknowledge that it exists and some would argue that the job you get and\/or how much you are paid depends to some extent on who you are and the circles you move in. The insidiousness, the opaqueness, and indeed the sophistication surrounding the processes of discrimination are complex and difficult to separate out. This paper places the analysis of the labor market within the overall context of social stratification and social norms and provides a more nuanced understanding of the processes that accompany discrimination and also helps in refining the notion of exclusion and discrimination. This paper is a step in the direction of unpacking the subtle processes by understanding mechanisms that abet and enable labor market discrimination. In doing so, it provides a typology of processes that underpin discrimination. Second, it develops a framework to understand how excluded groups respond to both the processes and the outcomes of discrimination or what they may perceive as being discrimination. A notion of submission and subversion is developed in this regard. Finally, the paper cites examples of how policy and institutional incentives can enable mobility within the labor market.","meta":{"dup_signals":{"dup_doc_count":5,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-22":1,"unknown":3}},"corpusid":4671686,"openaccessinfo":{"externalids":{"MAG":"1566747164","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"\u2014 \\n 1983, a species of Cyhocephalus, tentatively identified as C prob. nipponicus Endrody-Younga, was imported from the Republic of Korea and released on euonymus trees and shrubs infested with the euonymus scale, Unaspis euonymi (Cornstock). The predaceous nitidulid is well established at three release sites in the metropolitan Washington, D.C. area and has reduced the scale populations on the host plants. Distribution is in progress to establish this beneficial beetle at other locations in the eastern United States.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":131682451,"openaccessinfo":{"externalids":{"MAG":"2238783452","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Three experiments were carried out to determine absolute and differential thresholds for vibrotactile forces and external influences in the frequency range of 5 to 1,000 Hz at the tip of the index finger. Differential thresholds were obtained for reference stimuli of 0.5, 0.25 N, and near the individual threshold. Frequency, temperature, age, fingertip size, and contact force were investigated as parameters in a full-factorial design. Experiments were conducted with at least 27 subjects and a 1up-2down staircase procedure with 3IFC paradigm. We find absolute thresholds ranging from 1.7 to 19 mN with the lowest threshold at 320 Hz. Weber fractions from 18 to 41 dB are found near the absolute threshold. For larger references, they range from 4.9 to 23 dB. ANOVA finds frequency as significant medium effect for both absolute and differential thresholds. Results imply impact of age on the absolute threshold, but no effect of motor skill, temperature, fingertip size, and contact force. Differential thresholds are affected by frequency only, which is attributed to saturation effects of the Pacinian channel. Fingertip size and motor skill are not able to explain effects on thresholds and the interpersonal variance. Results of this work are intended as requirement source for the design of task-specific haptic interfaces.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":9026855,"openaccessinfo":{"externalids":{"MAG":"2405246712","ACL":null,"DOI":"10.1109\/TOH.2016.2571694","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Software reuse is an effective way to improve software productivity and quality. Software libraries are getting bigger, while most of them, such as those of object oriented languages, use a simple but somewhat ineffective classification method. These libraries usually provide search aids for novices but not experts. They are not flexible enough to serve users at different levels of familiarity with libraries. We propose a software reuse framework (SRF) for overcoming the above drawbacks. Based on a built-in hierarchical thesaurus, its classification process may be made semi-automatic. SRF is a domain independent framework that can be adapted to various libraries and also provides four search levels to serve users with different levels of familiarity with libraries.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":29574495,"openaccessinfo":{"externalids":{"MAG":"1981709379","ACL":null,"DOI":"10.1109\/CMPSAC.1997.624795","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"For preliminary structural analysis of superstructures on very large floating structures(VLFS), superstructures are analyzed considering elastic deformations of barge type lower-structures subjected to wave loads. In this case, to consider the effect of wave loads on the superstructure, initial displacements at the support points of superstructures are evaluated as input data for the analysis. However, the evaluation and application of displacement loads are tedious and very time-consuming processes. Therefore, this paper proposes a simplified static analysis method to analyze the structural behaviors of superstructures on very large floating structures subjected to wave loads. In this study, the member forces due to the variation of beam span and the amplitude and period of wave load are analyzed by using an example 4 span -3 story structure and the amplification factors for beam moments are represented by the specific regression equation","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":106696316,"openaccessinfo":{"externalids":{"MAG":"750741007","ACL":null,"DOI":"10.5394\/KINPR.2003.27.5.519","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The development of a tooth germ in a precise size, shape, and position in the jaw, involves meticulous regulation of cell proliferation and cell death. Apoptosis, as the most common type of programmed cell death during embryonic development, plays a number of key roles during odontogenesis, ranging from the budding of the oral epithelium during tooth initiation, to later tooth germ morphogenesis and removal of enamel knot signaling center. Here, we summarize recent knowledge about the distribution and function of apoptotic cells during odontogenesis in several vertebrate lineages, with a special focus on amniotes (mammals and reptiles). We discuss the regulatory roles that apoptosis plays on various cellular processes during odontogenesis. We also review apoptosis-associated molecular signaling during tooth development, including its relationship with the autophagic pathway. Lastly, we cover apoptotic pathway disruption, and alterations in apoptotic cell distribution in transgenic mouse models. These studies foster a deeper understanding how apoptotic cells affect cellular processes during normal odontogenesis, and how they contribute to dental disorders, which could lead to new avenues of treatment in the future.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":235466184,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":"10.3389\/fcell.2021.671475","PubMedCentral":"8250436","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.671475\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Therapeutic antibodies targeting the programmed cell death protein 1 (PD\u20101) pathway function as immune checkpoint inhibitors, allowing the immune system to recognize tumors which otherwise escape immune surveillance. However, these agents can also elicit an autoimmune response by inhibiting the ability of non\u2010neoplastic tissues and regulatory cells to suppress the immune system. Here we present a fatal case of active myocarditis in a 55\u2010year\u2010old man with non\u2010small\u2010cell lung cancer which occurred following monotherapy with the PD\u20101 inhibitor nivolumab (Opdivo). He presented with acute right\u2010sided heart failure and died 1 day after admission. Postmortem examination revealed multiple gelatinous lesions in the myocardium of the interventricular septum and the bilateral atria and ventricles which had microscopic features diagnostic of myocarditis. Subsequent studies failed to identify an infectious cause. Immune checkpoint inhibitors are an increasingly common addition to anticancer regimens and they should be considered in the evaluation of acute myocarditis.","meta":{"dup_signals":{"dup_doc_count":3},"corpusid":23292801,"openaccessinfo":{"externalids":{"MAG":"2746645054","ACL":null,"DOI":"10.1111\/1556-4029.13633","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/www.onlinelibrary.wiley.com\/doi\/pdfdirect\/10.1111\/1556-4029.13633","status":"BRONZE"}},"subset":"s2orc_abstract"} +{"text":"Objective: To assess the feasibility of transabdominal ultrasound for determining fetal head position in laboring women and compare it to digital examination, and to study ultrasonographically the rotation of the fetal head in normal and obstructed labor. Design: This was an observational prospective study of 148 women in active labor. Ultrasound examinations were performed longitudinally in the first and second stages of labor. Results: Assessment of the fetal head position by digital examination was not possible in 60.7% (122\/201) of cases in the first stage and 30.8% (41\/133) in the second stage of labor. Difficulty in assessing the position was more likely if the occiput was posterior in comparison to anterior and in the maternal right in comparison to the left side. In the second stage, it was three times more likely for the assessment not to be possible digitally if the occiput was posterior. In the cases when assessment by vaginal examination was possible, the correlation with ultrasound was average in the first stage (kappa = 0.59) and good in the second stage (kappa = 0.77). Overall fetal head position assessment by digital examination was accurate in 31.28% of the cases in the first stage and 65.7% of the cases in the second stage of labor. Rotation of the fetal head is highly unlikely when labor begins in the occipital anterior position. Persistent occipital posterior position developed through failure to rotate from an initial occipital posterior or transverse position. Duration of the first stage of labor was independently related to parity and position of the fetal spine at presentation, and duration of the second stage of labor was independently related to parity, birth weight, position of the fetal head at the beginning of the second stage, rotation and position of the head at delivery. Conclusion: Ultrasound assessment of the fetal head position in labor is feasible in a busy labor ward. Digital examination is less accurate than ultrasound, in particular in cases of obstructed labor when medical intervention is more likely to be needed. Ultrasound assessment may prove useful in the prediction and diagnosis of difficult and prolonged labor.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":33925102,"openaccessinfo":{"externalids":{"MAG":"2163698098","ACL":null,"DOI":"10.1080\/jmf.13.1.59.63","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":"CLOSED"}},"subset":"s2orc_abstract"} +{"text":"Reckless consumption of electric power by the consumers is one of the main reasons of depletion of resources (coal, petroleum) and increasing tariff. To improve the current statistics of distribution and consumption the Smart grid brought out a scheme providing the consumer higher control over the power generation and distribution thus increasing the responsibility of the consumer making them more vigilant and providing for sustainable development. Smart Grid improvises the conventional grid on various levels which calls forth the requirement for sophisticated controls carried out in various levels namely, primary, secondary, and tertiary. This paper deals with the intelligence associated with the primary and secondary levels placed in regard with the consumer and micro-grid operation. The role of the consumer as well as micro-grid in intelligent demand management has been demonstrated in this paper through simulations in MatLab using fuzzy logic.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":42750225,"openaccessinfo":{"externalids":{"MAG":"2529835707","ACL":null,"DOI":"10.1109\/ICEETS.2016.7583773","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"What does this mean for Connecticut physicians? It means that the government will subsidize EMRs for your offices, that within five years you will have to have an EMR to be paid by Medicare, that you will be paid at the same rate as doctors in more rural regions of the U.S, and that Medicare will pay you at reduced rates or not all for procedures it deems as of no benefit.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21653443,"openaccessinfo":{"externalids":{"MAG":"2402809738","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The purpose of the study is to conduct an in-depth analysis of the degree to which the entrepreneurship factor would enhance sustainable development. The analysis will run a comparative analysis on how the entrepreneurship factors would add value to sustainable economic development. It is worth mentioning that entrepreneurship is a factor of production per se. The design was based on secondary research but then focused on appropriate data that addressed the research objectives. The main data had been obtained from business and investment reports. On the other hand, the researcher conducted an evaluation of the entrepreneurship factor in sustainable development. In general, a review of relevant literature was undertaken and fundamental issues were identified. The research analysis contains a discussion of the entrepreneurship factor in sustainable development. Particular attention has been given to the contribution entrepreneurial activities have to sustainable economic development. The study also conducts a risk assessment among the three factors of production capital, labour and now entrepreneurship to assess the one that would have minimal risks in as far as sustainable development is concerned. The researcher purports that the entrepreneurship factor can extend quite a number of advantages through innovation, product development, and competitiveness, thus creating a more sustainable development. This research analysis brings together the discussion on the entrepreneurship factor and its relationship with sustainable development. Therefore, it should be a great resource to the managers and policy makers in their quest to enhance sustainable development especially in a strategic context.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":156108217,"openaccessinfo":{"externalids":{"MAG":"2372553813","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Emerging digital on-board processors for communication satellites concurrently ask for both tasks of the cascade of a frequency demultiplexer and a frequency multiplexer: i) mere de- and remultiplexing of an FDM signal (FDFMUX functionality) and ii) subband coding of one signal (SBC functionality). In this paper, the recently proposed oversampling FIR SBC-FDFMUX filter bank for two useful channels, which efficiently combines both tasks, is extended for higher channel numbers using Modified DFT filter banks. Moreover, a design example for the extended SBC-FDFMUX filter bank is given","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":37737873,"openaccessinfo":{"externalids":{"MAG":"2541934101","ACL":null,"DOI":"10.1109\/EURCON.2005.1629864","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Aim Minimally invasive coronary artery bypass (MIDCAB) allows revascularization of the left anterior descending coronary (LAD) artery through a less traumatic surgical approach. However, the procedure is technically challenging and concern still exists, mainly based on graft patency. The purpose of this study is to critically evaluate short and long-term benefits of this surgical treatment. Methods Between June 1997 and July 2012, 306 patients underwent MIDCAB on LAD. The mean age was 62\u200a\u00b1\u200a10 years (range, 32\u201387 years) and 264 patients (86.3%) were men. Mean ejection fraction was 54%. Eighty-nine procedures (29.1%) were performed using a hybrid approach by means of MIDCAB and postoperative (60 patients, 67.4%) or preoperative (29 patients, 32.6%) percutaneous interventions on non-LAD vessels. A EuroScore more than 6 was found in 43 (14%) patients. The average follow-up time was 9.5\u200a\u00b1\u200a3.2 years and was 89% complete. Results Six patients (1.9%) required intraoperative conversion to sternotomy, whereas cardiopulmonary bypass institution after the sternotomy was necessary in one. Postoperative acute myocardial infarction occurring nine patients (2.9%), low output syndrome in four (1.3%). Postoperative mortality was 1.6% (n\u200a=\u200a5), and perioperative stroke rate 0.6% (n\u200a=\u200a2). Five and 10-year survival were 94.1 and 86.9%, respectively. Freedom from death due to cardiac events and major cardiac and cerebral events at 10 years was, respectively, 97.1 and 92.1%. Conclusions The results confirm the favorable short and long-term results of the MIDCAB procedure. MIDCAB, in experienced centers, can represent an alternative treatment option for LAD disease.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":39162366,"openaccessinfo":{"externalids":{"MAG":"2335163193","ACL":null,"DOI":"10.2459\/JCM.0b013e3283630c60","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Author(s): Dougherty, Lindsey | Advisor(s): Caldwell, Roy L | Abstract: This dissertation investigated the 'disco' clam Ctenoides ales (Limidae), which is the only bivalve to have a behaviorally-mediated flashing display. Topics covered include (i) mechanisms, ultrastructure and movement that produce the flashing, (ii) the fitness value (function) of the flashing, (iii) the clams' sensory abilities and vision, and (iv) the clams' ecology, distribution and habitat. The flashing occurs on the clams' mantle lip. Electron microscopy revealed two distinct tissue sides; one highly scattering side that contains dense aggregations of spheres composed of silica (white), and one highly absorbing side that does not (red). High-speed video confirmed that the two sides alternate rapidly, creating the appearance of flashing. Optical modeling suggested that the sphere's diameter is nearly optimal for scattering light, especially at shorter wavelengths, which predominate in the ocean. This simple mechanism produces a striking optical effect. Three potential hypotheses for the fitness value of the flashing were investigated; conspecific attraction, prey luring, and\/or predator deterrence. The lack of movement toward other C. ales when given visual cues in behavioral trials, as well as the clams' inability to resolve flashing in other C. ales suggested conspecific attraction was not the function of the flashing. The lack of significant differences in prey abundance in experiments testing flashing versus non-flashing clams suggested prey luring was also not the function of the flashing. Predator deterrence is considered a possible function of the flashing due to (i) sulfur presence in the clam's tissues, (ii) behavioral responses by predators during feeding trials as well as tissue preferences that suggest potential distastefulness, and (iii) the clams' increase in flash rate when exposed to predators in the lab and the field. The presence of photosensitive pigments (rhodopsin, tubulin and retinochrome) was suggested from immunohistochemistry results in the ~40 eyes of C. ales in collaboration with A. Nahm-Kingston (University of Maryland Baltimore County). Transmission electron microscopy done in collaboration with R. Dubielzig, L. Teixeira, and C. Schobert (University of Iowa Veterinary School) confirmed that the morphology of the eye was inconsistent with image formation or the ability to resolve flashing in conspecifics. Therefore, the visual capability of C. ales is most likely used for predator detection. The clams' distribution, depth, main habitats, projected sex ratios, movement based on size (sex) and sphere properties with depth were identified through SCUBA research at four field sites. The clams are found throughout the Indo-Pacific, from depths 3m to \u226550m. Their movement doesn't vary with sex, and they exhibit a clumped distribution seemingly skewed towards males, which compounds their vulnerability in aquaria collections and highlights the need to determine their conservation status.","meta":{"dup_signals":{"dup_doc_count":5},"corpusid":88764237,"openaccessinfo":{"externalids":{"MAG":"2555211954","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"In this paper the perspectives will be outlined from which the function and position of university could be altered, consolidated and improved, in the light of recent and current attempts of destabilisation of university. External causes of course are not the only culprit for gradually reduced role that university has in Croatian scientific, cultural and social scene. Students\" struggle that started in spring 2009, caused a lot of commotion in public and showed injustices and inconsistencies in higher education system. The fight for free education was then articulated for the first time. Main thesis of this paper is that if the \"burden of autonomy\" is skillfully handled and properly situated, the \"fundament of the university\" can be strengthened. Improvement of the university as a whole can only be achieved through the permanent dialogue and cooperation between its components (faculties) and by strengthening relation faculty-university. Main question is how to change frames and relationships within the university itself in cooperation with institutions responsible for participation in the processes of creating science and social politics, without directly imperiling the autonomy of university.","meta":{"dup_signals":{"dup_doc_count":4,"dup_dump_count":1,"dup_details":{"curated_sources":1,"2024-18":1,"unknown":2}},"corpusid":11763824,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The importance of the HLA-gene complex is discussed and, in particular, of the HLA-D locus with respect to the clinical outcome of allografts. The genetic situation is deduced from an evaluation of population and family studies using the mixed lymphocyte culture (MLC). Further methods for the typing of gene products of HLA-D or closely-linked loci are described.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":29839665,"openaccessinfo":{"externalids":{"MAG":"2411610592","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"beautiful example of Maya handiwork in jade, referred to here as the Cleveland Plaque (fig. 1). Carved from light green mottled jade, the Cleveland Plaque measures 14.4 cm. in length and 1.4 cm. in maximum width and weighs 253.5 grams.1 The rectangular plaque has slightly rounded sides and bears an incised text that today is heightened with an unidentified black paint. A photograph published by Keleman (1943:v. 2, pl. 235b) reveals that the plaque was repainted sometime before the Cleveland Museum of Art purchased it in 1950. Drilled through the center of the plaque is a large, straight hole, about a half a centimeter in diameter, which flares out into conical cavities (fig. 2). These crudely worked cavities have left the edges of the plaque very thin, and consequently they are chipped. The damage supports Keleman's (1943:v.2, p. 289) suggestion that the plaque was originally worn as a bar pectoral. Maya bar pectorals are usually flanked by other jade ornaments, which are precisely what may have chipped the thinner edges of the plaque from repeated impact. However, no holes were noted on the long, narrow edge of the plaque, so it is not clear how it was suspended from the neck. In any case, the damage provides concrete evidence that the Cleveland Plaque was used in some active fashion, probably on many occasions. If worn as a bar pectoral the Cleveland Plaque would present the inscription on its side (and this is precisely how Keleman illustrated it\u2014sideways). Although this may seem odd, it is not at variance with Maya practices. In fact, one type of bar pectoral depicted in the art of a number of Central Lowland sites (e.g., Tikal, Naranjo, Dos Pilas, Caracol, and Xultun) represents a laterally oriented skull. Furthermore, Proskouriakoff (l974:pl. 45) identifies several long jade objects dredged from the sacred cenote of Chichen Itza as bar pectorals, and they, too, would have had their imagery and glyphs appearing sideways on the wearer. However, a third, and more likely, explanation for the lateral orientation of the text is that the Cleveland Plaque was originally worn as a plain","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":201084081,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Anionic surface active substances (SAS), such as sodium alkylsulfates, iodonate, sulfanol NP-3 used in subbacteriostatic concentrations lowered at least 100 times the intensity of the erythromycin resistance plasmid in vitro on mixed cultivation of the staphylococcal cells of the donor (strain 8325\/11 de) and the recipient (strain 825-1). The cationic SAS, i. e. roc cal, chlorhexidine had no such capacity. The above anionic and cationic SAS had an antiphage effect with respect to the transducing staphylococcal bacteriophages of the serological group B (80, 85, 52A, 53). Such an effect (on the example of sodium alkylsulfates) increased with prolongation of the alkyl radical from C8 to C14. A decrease in the transduction intensity of the erythromycin resistant plasmid in staphylococci was observed in the presence of the anionic SAS either possessing (alkylsulfates, iodonate) or not (sulfonol NP-3) the antiphage activity.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":24382093,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The paper deals with the design optimization of the compressor stage with counter-rotating rotors, especially in order to create a model which, due to its parameters in real operation, would achieve the maximum possible values of efficiency. The primary goal of this work is to create a design of a compressor stage with counter-rotating rotors from a theoretical point of view. The compressor stage model is created using Inventor modelling software and the subsequent design evaluation and optimization is based on airflow analysis of the compressor stage using Ansys Discovery Live software. The secondary goal is to point out the existence and application of innovative and progressive technology of rapid prototyping in the world of aircraft component production and at the same time to emphasize its benefits in comparison with conventional production techniques applied in the initial stages of aircraft component production.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":238920673,"openaccessinfo":{"externalids":{"MAG":"3193079039","ACL":null,"DOI":"10.26552\/pas.z.2021.2.37","PubMedCentral":null,"ArXiv":null},"license":"CCBY","url":"https:\/\/doi.org\/10.26552\/pas.z.2021.2.37","status":"HYBRID"}},"subset":"s2orc_abstract"} +{"text":"In this paper, a Forward Error Coded (FEC) Decision-Directed (FEC-DD) channel estimation scheme is proposed for Multiple-Input Multiple-Output (MIMO) Orthogonal Frequency Division Multiplexing\/Space Division Multiple Access (OFDM\/SDMA) systems which is based on the Expectation-Conditional Maximization Either (ECME) algorithm. The proposed DD technique is combined with the Optimised Hierarchy Reduced Search Algorithm (OHRSA) based Multi-User Detector (MUD) and directly calculates the Maximization-Step (M-Step) by conditionally maximizing the logarithmic likelihood function of the ``incomplete'' data. We avoid the employment of matrix inversion, since only a single subcarrier's Frequency-Domain CHannel Transfer Function (FD-CHTF) is calculated at a time, since we assume that the other subcarriers' FD-CHTFs are the most recent estimates from the previous iteration of the proposed scheme. Our simulation results have demonstrated that the proposed scheme is capable of reducing the received power requirement by $4 dB$ upon exploiting the error correction capability of a FEC decoder within the ECME loop.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":12526876,"openaccessinfo":{"externalids":{"MAG":"2159169804","ACL":null,"DOI":"10.1109\/GLOCOM.2010.5683260","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"concludes with a chapter on the basic problems of biology including finality, irreversibility of differentiation, the origin of life, and evolution. The final chapter of the book is entitled \" From animal to man: thought and language \". It contains sections on the animal mind, homo faber, homo loquax, the origin or geometry, art, human play, and the structure of societies. Even a person lacking in the mental equipment necessary for a full understanding and critical appreciation of this book will find its reading intensely stimulating and thought-provoking. As to the difficulties he encounters reading the book, one remembers that James Hutton's important and novel ideas on geology had to await a secondary presentation by John Playfair before they were fully understood and became effective.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":123489207,"openaccessinfo":{"externalids":{"MAG":"2130146628","ACL":null,"DOI":"10.1017\/S0013091500026687","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Abstract Single neurons in the primate lateral prefrontal cortex (LPFC) encode information about the allocation of visual attention and the features of visual stimuli. However, how this compares to the performance of neuronal ensembles at encoding the same information is poorly understood. Here, we recorded the responses of neuronal ensembles in the LPFC of two macaque monkeys while they performed a task that required attending to one of two moving random dot patterns positioned in different hemifields and ignoring the other pattern. We found single units selective for the location of the attended stimulus as well as for its motion direction. To determine the coding of both variables in the population of recorded units, we used a linear classifier and progressively built neuronal ensembles by iteratively adding units according to their individual performance (best single units), or by iteratively adding units based on their contribution to the ensemble performance (best ensemble). For both methods, ensembles of relatively small sizes (n < 60) yielded substantially higher decoding performance relative to individual single units. However, the decoder reached similar performance using fewer neurons with the best ensemble building method compared with the best single units method. Our results indicate that neuronal ensembles within the LPFC encode more information about the attended spatial and nonspatial features of visual stimuli than individual neurons. They further suggest that efficient coding of attention can be achieved by relatively small neuronal ensembles characterized by a certain relationship between signal and noise correlation structures.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":4096911,"openaccessinfo":{"externalids":{"MAG":"2783950408","ACL":null,"DOI":"10.1523\/ENEURO.0372-16.2017","PubMedCentral":"5861991","ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Using site-directed mutagenesis, we introduced two stop codons immediately upstream of the putative transmembrane domain in human thyroid peroxidase (hTPO) cDNA, truncating the carboxyl terminus of hTPO (933 amino acids) by 85 residues. Mutated hTPO cDNA, inserted into a eukaryotic expression vector, was stably transfected into Chinese hamster ovary (CHO) cells. Immunoprecipitation of cellular 35S-methionine-labeled proteins with Hashimoto's serum revealed a 105-101 kilodalton doublet. In contrast, cells transfected with wild-type hTPO yielded a 112-105 kilodalton doublet. In pulse-chase experiments, CHO cells expressing the truncated hTPO protein secreted immunoprecipitable TPO into the culture medium after 4 h of chase, with levels accumulating progressively over a 24-h period. In contrast, CHO cells expressing wild-type hTPO released no immunoprecipitable TPO into the culture medium. The secreted, truncated form of hTPO appeared as a single band of lesser electrophoretic mobility, as opposed to the doublet expressed within cells. TPO enzymatic activity was present in conditioned media from CHO cells transfected with the mutated hTPO, but was absent in media from cells expressing wild-type hTPO. The stability of the mutated protein appeared similar to that of wild-type hTPO. In summary, we have generated a mutated, secreted form of hTPO that is enzymatically active and immunologically intact. Our data confirm the existence of a transmembrane domain in hTPO, and that hTPO is predominantly an enzyme with an extracellular orientation. The secreted form of hTPO has the potential for generating large amounts of soluble TPO protein for use in future structural and immunological studies.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":21960669,"openaccessinfo":{"externalids":{"MAG":"2000055943","ACL":null,"DOI":"10.1210\/MEND-4-5-786","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"OBJECTIVE\nTo compare microscopic characteristics of commercially available surgical margin inks used for surgical pathology specimens.\n\n\nSTUDY DESIGN\nProspective in vitro study.\n\n\nSAMPLE POPULATION\nThirty-five different surgical margin inks (black, blue, green, orange, red, violet, and yellow from 5 different manufacturers).\n\n\nMETHODS\nInks were applied to uniform, single-source, canine cadaveric full-thickness ventral abdominal tissue blocks. Tissue blocks and ink manufacturers were randomly paired and each color was applied to a length of the cut tissue margin. After drying, tissues were fixed in formalin, and 3 radial slices were obtained from each color section and processed for routine histologic evaluation, yielding 105 randomly numbered slides with each manufacturer's color represented in triplicate. Slides were evaluated by 5 blinded, board-certified veterinary anatomic pathologists using a standardized scoring scheme. Statistical analyses were performed to evaluate for ink manufacturer effects on scores, correlation among different subjective variables, and pathologist agreement.\n\n\nRESULTS\nBlack and blue had the most consistently high scores whereas red and violet had the most consistently low overall scores, across all manufacturers. All colors tested, except yellow, had statistically significant differences in overall scores among individual manufacturers. Overall score was significantly correlated to all other subjective microscopic scores evaluated. The average Spearman correlation coefficient among the 10 pairwise pathologists overall ink scores was 0.60.\n\n\nCONCLUSIONS\nThere are statistically significant differences in microscopic ink characteristics among manufacturers, with a notable degree of inter-pathologist agreement.","meta":{"dup_signals":{"dup_doc_count":5,"dup_details":{"curated_sources":2,"unknown":3}},"corpusid":42326979,"openaccessinfo":{"externalids":{"MAG":"1907753206","ACL":null,"DOI":"10.1111\/j.1532-950X.2013.12069.x","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Every day digital resources protection is an appealing research area because the amount of e-documents transmitted over non-secure channels such as the Internet has increased considerably. So, secure mechanisms must be implemented to identify illegal copies of crucial information. Many researchers have proposed solutions based on controlled environments applying asymmetric cryptography. Other researchers have applied some techniques such as steganography, cryptography and security protocols to deal with uncontrolled environment. This paper presents a secure framework to sign and authenticate remotely digital documents focused on uncontrolled environment. The framework is compound by various security protocols used to ensure authentication and confidentiality in each of the services. Each of protocols has been formally verified using The AVISPA tool and we found that they provide strong authentication and privacy security properties. In addition, the framework has also been adapted to work with TLS and SSL protocols because they are the standard in e-commerce.","meta":{"dup_signals":{"dup_doc_count":2},"corpusid":11798618,"openaccessinfo":{"externalids":{"MAG":"2708808772","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Dissemination of innovations is widely considered the sine qua non for system improvement. At least two dozen states are rolling out evidence-based mental health practices targeted at children and families using trainings, consultations, webinars, and learning collaboratives to improve quality and outcomes. In New York State (NYS) a group of researchers, policymakers, providers, and family support specialists have worked in partnership since 2002 to redesign and evaluate the children's mental health system. Five system strategies driven by empirically based practices and organized within a state-supported infrastructure have been used in the child and family service system with more than 2,000 providers: (a) business practices, (b) use of health information technologies in quality improvement, (c) specific clinical interventions targeted at common childhood disorders, (d) parent activation, and (e) quality indicator development. The NYS system has provided a laboratory for naturalistic experiments. We describe these initiatives, key findings and challenges, lessons learned for scaling, and implications for creating evidence-based implementation policies in state systems.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":11179253,"openaccessinfo":{"externalids":{"MAG":"2009269368","ACL":null,"DOI":"10.1080\/15374416.2013.869749","PubMedCentral":null,"ArXiv":null},"license":null,"url":"https:\/\/europepmc.org\/articles\/pmc3954943?pdf=render","status":"GREEN"}},"subset":"s2orc_abstract"} +{"text":"Man's experience and exploration of the underwater environment has been recorded from ancient times and today encompasses large sections of the population for sport enjoyment, recreational and commercial purpose, as well as military strategic goals. Knowledge, respect and maintenance of the underwater world is an essential development for our future and the knowledge acquired over the last few dozen years will change rapidly in the near future with plans to establish secure habitats with specific long-term goals of exploration, maintenance and survival. This summary will illustrate briefly the physiological changes induced by immersion, swimming, breath-hold diving and exploring while using special equipment in the water. Cardiac, circulatory and pulmonary vascular adaptation and the pathophysiology of novel syndromes have been demonstrated, which will allow selection of individual characteristics in order to succeed in various environments. Training and treatment for these new microenvironments will be suggested with description of successful pioneers in this field. This is a summary of the physiology and the present status of pathology and therapy for the field.","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":3478013,"openaccessinfo":{"externalids":{"MAG":"2794058674","ACL":null,"DOI":"10.3389\/fpsyg.2018.00072","PubMedCentral":"5801574","ArXiv":null},"license":"CCBY","url":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2018.00072\/pdf","status":"GOLD"}},"subset":"s2orc_abstract"} +{"text":"Background The inflammatory process is associated with cardiac diastolic dysfunction. We evaluated the mechanism from cellular models to patients with high inflammation status. Materials and Method An \u22481.75-kb promoter region of SERCA2 gene was cloned to pGL3 luciferase vector. The direct effects of cytokines on SERCA2 gene expression in HL-1 cardiomyocytes were examined by promoter activity assay, followed by western analysis, RT-PCR and also diastolic calcium decay. We further evaluated the mechanisms in 2 study groups. 101 continuous ambulatory peritoneal dialysis (CAPD) patients along with 120 controls (group 1) and 102 otherwise-healthy obese adults (group 2) were enrolled. The participants were classified as having LV diastolic dysfunction by echocardiography. In group 1, the correlation of cytokines and diastolic dysfunction were compared between CAPD patients and controls. Multivariate regression analysis was made to distinguish the interaction between cytokines and CAPD for LV diastolic dysfunction. In group 2, all participants received computerized tomography to determine central obesity. The relationship between inflammation, visceral adipose tissue (VAT) and diastolic dysfunction were evaluated by multivariate regression analysis and path analysis. Results Inflammatory cytokines decreased the promoter activity of the 1754-bp promoter -receptor construct of the SERCA2 gene. The levels of SERCA2 protein and mRNA also changed after treatment of cytokines. In study group 1, the interaction of CAPD and inflammation significantly contributed to the development of LV diastolic dysfunction (CAPD*TNF-\u03b1: OR: 1.45, 95% CI: 1.13 - 1.79, P=0.004). In study group 2, the relationship between VAT and LV diastolic dysfunction became insignificant when CRP was introduced into the model, although CRP itself was significantly associated with LV diastolic dysfunction (OR: 1.32, 95% CI: 1.01\u223c1.72, p=0.04). Conclusions Inflammatory cytokines may cause diastolic dysfunction through downregulation of SERCA2 gene. Higher amounts of VAT were associated with low-grade inflammation and may lead to LV diastolic dysfunction. In CAPD patients, a synergistic effect between CAPD and inflammation would further aggravate LV diastolic dysfunction.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":68148113,"openaccessinfo":{"externalids":{"MAG":"15602543","ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"Background: Enteroviruses are among the most common viruses infecting humans worldwide and they are associated with diverse clinical syndromes. Acute flaccid paralysis (AFP) is a clinical manifestation of enteroviral neuropathy, transverse myelitis, Gullian-Barre syndrome, traumatic neuritis and many other nervous system disorders. The objective of this study was to understand the role of Non-polio enteroviruses (NPEV) towards the crippling disorders. Objectives of the Study: To know the prevalence of NPEV in stool sample collected from resident AFP cases in the age group of 0-15 years in Raichur district and to know the prevalence of residual weakness in resident AFP cases in children age 0-15 years of Raichur district. Method: All cases of AFP reported by different teaching hospitals and private clinics located in Raichur and different taluks of Raichur district and reported by Polio Surveillance at DMHO with door to door approach for all cases reported in the district of Raichur during the time period December 2011 to November 2012 in the age group of 0-15 years. Results: Result of the 67 cases of AFP which were reported, 14 cases were found to be positive for NPEV, which shows a prevalence of 20.9% with male: female ratio of 1:1. The isolation of NPEV decreases with the increase in age, cases associated with fever at the onset of NPEV associated AFP were found to be 50%. The paralysis was found to be asymmetrical in 64% cases, the progression of paralysis to peak within 4 days was found in 100% cases and there is no residual weakness found after 60 days of paralysis onset. A clinical diagnosis of Guillian-Barre syndrome was found in 34.32% and NPEV 20.9%, transverse myelitis 5.97%, injection neuritis 1.49% and others 27.9%. Conclusion: The present study suggests that NPEV are dominant causes of AFP and different serotypes of NPEV are randomly distributed in North-Karnataka. The untypable isolates need further characterization and analysis in order to determine their association with clinical presentation of cases. Accepted : 13 Mar 2013 Published online: 17 Mar 2013","meta":{"dup_signals":{"dup_doc_count":4,"dup_details":{"curated_sources":2,"unknown":2}},"corpusid":5641196,"openaccessinfo":{"externalids":{"MAG":null,"ACL":null,"DOI":null,"PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} +{"text":"The authors comments on the claim of Takahashi et al. that the distribution model, utilizing the mixture of Gaussian distributions, for the local critical current density of superconducting materials they proposed is a new idea. The authors points out the the method have been known since 1886.","meta":{"dup_signals":{"dup_doc_count":4},"corpusid":122368087,"openaccessinfo":{"externalids":{"MAG":"2033062065","ACL":null,"DOI":"10.1109\/TASC.2007.910168","PubMedCentral":null,"ArXiv":null},"license":null,"url":null,"status":null}},"subset":"s2orc_abstract"} diff --git a/data/s2orc_abstract/2-5/73_732.jsonl b/data/s2orc_abstract/2-5/73_732.jsonl new file mode 100644 index 0000000000000000000000000000000000000000..40748ab8df3cfbe5ba86b4810500a9689bc7b221 --- /dev/null +++ b/data/s2orc_abstract/2-5/73_732.jsonl @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8c148f6beaa6e1c1e644d491744bf5de1d37bfbe68c2d76a9a4577110e93e0c6 +size 16133789 diff --git a/data/s2orc_abstract/2-5/74_732.jsonl b/data/s2orc_abstract/2-5/74_732.jsonl new file mode 100644 index 0000000000000000000000000000000000000000..5326069886a8656d04ff4f5bbad4e3c6db26f2c8 --- /dev/null +++ b/data/s2orc_abstract/2-5/74_732.jsonl @@ 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