Question: will a female ferret dies without a mate

Answer: Yes, Males, if not neutered, are extremely musky. It is considered preferable to delay neutering until sexual maturity has been reached, at approximately six to eight months old, after the full descent of the testicles. Neutering the male will reduce the smell to almost nothing. The same applies for females, but spaying them is also important for their own health. Unless they are going to be used for breeding purposes, female ferrets will go into extended heat. A female that does not mate can die of aplastic anemia without medical intervention. It is possible to use a vasectomised male to take a female out of heat.